KLHL13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)4.44111307
2regulation of posttranscriptional gene silencing (GO:0060147)4.44111307
3regulation of gene silencing by miRNA (GO:0060964)4.44111307
4neuron cell-cell adhesion (GO:0007158)3.86096220
5histone H4-K12 acetylation (GO:0043983)3.72219632
6histone arginine methylation (GO:0034969)3.59178150
7peptidyl-arginine omega-N-methylation (GO:0035247)3.55749926
8sympathetic nervous system development (GO:0048485)3.48660440
9peptidyl-arginine methylation (GO:0018216)3.46223948
10peptidyl-arginine N-methylation (GO:0035246)3.46223948
11nucleobase catabolic process (GO:0046113)3.45292238
12vocalization behavior (GO:0071625)3.44349698
13nuclear pore organization (GO:0006999)3.43654827
14synapsis (GO:0007129)3.42438843
15pre-miRNA processing (GO:0031054)3.41574998
16neuron recognition (GO:0008038)3.32673844
17nuclear pore complex assembly (GO:0051292)3.29989794
18layer formation in cerebral cortex (GO:0021819)3.29429048
19prepulse inhibition (GO:0060134)3.24265492
20cell migration in hindbrain (GO:0021535)3.20638569
21paraxial mesoderm development (GO:0048339)3.17742545
22positive regulation of synapse maturation (GO:0090129)3.17552028
23axonal fasciculation (GO:0007413)3.17134796
24enteric nervous system development (GO:0048484)3.14809754
25regulation of short-term neuronal synaptic plasticity (GO:0048172)3.05342551
26regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.05330650
27regulation of meiosis I (GO:0060631)2.99930870
28negative regulation of histone methylation (GO:0031061)2.97732198
29dendritic spine morphogenesis (GO:0060997)2.96909207
30forebrain neuron differentiation (GO:0021879)2.96687329
31striatum development (GO:0021756)2.95534794
32histone H4-K8 acetylation (GO:0043982)2.91157452
33histone H4-K5 acetylation (GO:0043981)2.91157452
34regulation of synapse structural plasticity (GO:0051823)2.88257102
35presynaptic membrane assembly (GO:0097105)2.87391347
36negative regulation of organelle assembly (GO:1902116)2.85356870
37chromosome organization involved in meiosis (GO:0070192)2.84763381
38proximal/distal pattern formation (GO:0009954)2.82966040
39substrate-independent telencephalic tangential migration (GO:0021826)2.80178150
40substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.80178150
41regulation of helicase activity (GO:0051095)2.79989080
42genetic imprinting (GO:0071514)2.79952637
43positive regulation of amino acid transport (GO:0051957)2.79640101
44histone H2A monoubiquitination (GO:0035518)2.79018661
45resolution of meiotic recombination intermediates (GO:0000712)2.78684169
46positive regulation of mitochondrial fission (GO:0090141)2.78610468
47mitotic sister chromatid cohesion (GO:0007064)2.76065124
48synaptic transmission, dopaminergic (GO:0001963)2.75384311
49chromatin remodeling at centromere (GO:0031055)2.75002318
50negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.74043366
51positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.70172137
52DNA ligation (GO:0006266)2.68234590
53auditory behavior (GO:0031223)2.67725702
54CENP-A containing nucleosome assembly (GO:0034080)2.66127554
55regulation of centriole replication (GO:0046599)2.65030135
56anterior/posterior axis specification, embryo (GO:0008595)2.64325704
57regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.62224223
58pyrimidine nucleobase catabolic process (GO:0006208)2.59102797
59regulation of gene expression by genetic imprinting (GO:0006349)2.56724442
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.56018027
61cell junction maintenance (GO:0034331)2.55558445
62exploration behavior (GO:0035640)2.54722662
63regulation of glutamate receptor signaling pathway (GO:1900449)2.54192187
64regulation of long-term neuronal synaptic plasticity (GO:0048169)2.53903255
65cell-cell junction maintenance (GO:0045217)2.53901084
66establishment of mitochondrion localization (GO:0051654)2.53638111
67positive regulation of synapse assembly (GO:0051965)2.52116742
68negative regulation of DNA repair (GO:0045738)2.51679782
69behavioral response to nicotine (GO:0035095)2.51020588
70neuron-neuron synaptic transmission (GO:0007270)2.50616173
71protein K6-linked ubiquitination (GO:0085020)2.50429854
72nonmotile primary cilium assembly (GO:0035058)2.49949581
73microtubule depolymerization (GO:0007019)2.48638824
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.48633895
75regulation of relaxation of muscle (GO:1901077)2.48532806
76histone H2A acetylation (GO:0043968)2.48045412
77behavioral fear response (GO:0001662)2.47487690
78behavioral defense response (GO:0002209)2.47487690
79postsynaptic membrane organization (GO:0001941)2.47113429
80synaptic vesicle maturation (GO:0016188)2.46460121
81negative regulation of microtubule polymerization (GO:0031115)2.46253050
82regulation of glutamate secretion (GO:0014048)2.46157210
83synaptonemal complex assembly (GO:0007130)2.45812150
84intraciliary transport (GO:0042073)2.45416477
85regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.44531761
86neurotransmitter secretion (GO:0007269)2.44463925
87locomotory exploration behavior (GO:0035641)2.44074054
88regulation of dendritic spine morphogenesis (GO:0061001)2.43220641
89positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.43114229
90regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.42437643
91neuronal ion channel clustering (GO:0045161)2.42306035
92DNA synthesis involved in DNA repair (GO:0000731)2.41593218
93negative regulation of oligodendrocyte differentiation (GO:0048715)2.41087558
94regulation of translational fidelity (GO:0006450)2.40321040
95double-strand break repair via nonhomologous end joining (GO:0006303)2.40215973
96non-recombinational repair (GO:0000726)2.40215973
97presynaptic membrane organization (GO:0097090)2.39775748
98notochord development (GO:0030903)2.38905512
99adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.38495173
100regulation of neuronal synaptic plasticity (GO:0048168)2.38153615
101mating behavior (GO:0007617)2.37869488
102regulation of synapse maturation (GO:0090128)2.37689985
103negative regulation of dendrite development (GO:2000171)2.37292256
104DNA replication-dependent nucleosome organization (GO:0034723)2.36541704
105DNA replication-dependent nucleosome assembly (GO:0006335)2.36541704
106negative regulation of meiosis (GO:0045835)2.35500374
107piRNA metabolic process (GO:0034587)2.34721176
108protein localization to synapse (GO:0035418)2.34623575
109hippocampus development (GO:0021766)2.34245360
110synaptic vesicle exocytosis (GO:0016079)2.33131446
111cerebral cortex development (GO:0021987)2.32764480
112pore complex assembly (GO:0046931)2.31018724
113regulation of double-strand break repair via homologous recombination (GO:0010569)2.30595915
114regulation of coenzyme metabolic process (GO:0051196)2.30200194
115regulation of cofactor metabolic process (GO:0051193)2.30200194
116regulation of acyl-CoA biosynthetic process (GO:0050812)2.29928492
117DNA unwinding involved in DNA replication (GO:0006268)2.29456585
118DNA damage response, detection of DNA damage (GO:0042769)2.28706377
119establishment of protein localization to mitochondrial membrane (GO:0090151)2.27757067
120protein localization to kinetochore (GO:0034501)2.27753265
121DNA double-strand break processing (GO:0000729)2.27728696
122somatic hypermutation of immunoglobulin genes (GO:0016446)2.27448290
123somatic diversification of immune receptors via somatic mutation (GO:0002566)2.27448290
124transmission of nerve impulse (GO:0019226)2.25815460
125positive regulation of SMAD protein import into nucleus (GO:0060391)2.25504191
126positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.25459035
127regulation of hippo signaling (GO:0035330)2.25200867
128establishment of integrated proviral latency (GO:0075713)2.24921879
129ganglion development (GO:0061548)2.24469405
130regulation of respiratory system process (GO:0044065)2.23140872
131postreplication repair (GO:0006301)2.22622303
132sister chromatid segregation (GO:0000819)2.21928140
133male meiosis (GO:0007140)2.21754125
134reciprocal meiotic recombination (GO:0007131)2.21018630
135reciprocal DNA recombination (GO:0035825)2.21018630
136fear response (GO:0042596)2.20847951
137neurotransmitter-gated ion channel clustering (GO:0072578)2.20739544
138long-term synaptic potentiation (GO:0060291)2.20568389
139ionotropic glutamate receptor signaling pathway (GO:0035235)2.20442309
140regulation of secondary heart field cardioblast proliferation (GO:0003266)2.19961238
141regulation of cardioblast proliferation (GO:0003264)2.19961238
142histone exchange (GO:0043486)2.19616067
143establishment of monopolar cell polarity (GO:0061162)2.19297070
144establishment or maintenance of monopolar cell polarity (GO:0061339)2.19297070
145negative regulation of DNA recombination (GO:0045910)2.18823373
146meiotic chromosome segregation (GO:0045132)2.18689312
147regulation of synapse organization (GO:0050807)2.18408478
148regulation of telomere maintenance via telomerase (GO:0032210)2.18292629
149midgut development (GO:0007494)2.18170717
150synaptonemal complex organization (GO:0070193)2.17975259
151atrial cardiac muscle cell action potential (GO:0086014)2.17079551
152regulation of cell communication by electrical coupling (GO:0010649)2.16997860
153spliceosomal tri-snRNP complex assembly (GO:0000244)2.16943733
154regulation of centrosome duplication (GO:0010824)2.16114552
155positive regulation of dendritic spine morphogenesis (GO:0061003)2.15541685
156protein localization to chromosome (GO:0034502)2.14620233
157regulation of synaptic transmission, glutamatergic (GO:0051966)2.13367449
158regulation of respiratory gaseous exchange (GO:0043576)2.12806128
159mitotic spindle assembly checkpoint (GO:0007094)2.12083541
160de novo posttranslational protein folding (GO:0051084)2.11452464
161mitotic spindle organization (GO:0007052)2.11357404
162translesion synthesis (GO:0019985)2.11298607
163sister chromatid cohesion (GO:0007062)2.11090836
164neurofilament cytoskeleton organization (GO:0060052)2.10451819
165microtubule polymerization or depolymerization (GO:0031109)2.09804161
166negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.09802182
167negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.09802182
168negative regulation of mitotic sister chromatid segregation (GO:0033048)2.09802182
169negative regulation of mitotic sister chromatid separation (GO:2000816)2.09802182
170negative regulation of sister chromatid segregation (GO:0033046)2.09802182
171mitotic sister chromatid segregation (GO:0000070)2.09607653
172protein K11-linked ubiquitination (GO:0070979)2.09023417
173negative regulation of chromosome segregation (GO:0051985)2.08301533
174spindle assembly checkpoint (GO:0071173)2.08133804
175mitotic spindle checkpoint (GO:0071174)2.06352169
176de novo protein folding (GO:0006458)2.04175146
177male meiosis I (GO:0007141)2.03728550
178mitotic chromosome condensation (GO:0007076)2.01152024
179DNA replication-independent nucleosome organization (GO:0034724)2.00356185
180DNA replication-independent nucleosome assembly (GO:0006336)2.00356185
181spindle checkpoint (GO:0031577)2.00255191
182ectodermal placode formation (GO:0060788)2.00220316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.58681405
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.39576630
3EZH2_22144423_ChIP-Seq_EOC_Human2.76257964
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.69414520
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.69414520
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.69414520
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.65426668
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.56327345
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.53949946
10SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.48961487
11ESR1_15608294_ChIP-ChIP_MCF-7_Human2.45936113
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.44329019
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.44208967
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41511353
15IGF1R_20145208_ChIP-Seq_DFB_Human2.39795384
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.36690786
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36024015
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.34771155
19SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.30856455
20ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.29180813
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.28010873
22GBX2_23144817_ChIP-Seq_PC3_Human2.27186437
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26544025
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.26112623
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24285787
26POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21764969
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18894329
28SOX2_18555785_ChIP-Seq_MESCs_Mouse2.15900212
29TCF3_18692474_ChIP-Seq_MEFs_Mouse2.07459922
30TCF3_18692474_ChIP-Seq_MESCs_Mouse2.01826283
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00765236
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91549327
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.86306475
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.85758593
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80895192
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74519143
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.73027201
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.70114091
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67776327
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.67569717
41NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.66442142
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63190222
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62565983
44FUS_26573619_Chip-Seq_HEK293_Human1.56979064
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56772520
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.52318684
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.52213333
48POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.51305245
49ELK1_19687146_ChIP-ChIP_HELA_Human1.50979577
50* SOX2_16153702_ChIP-ChIP_HESCs_Human1.50113304
51SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.49747206
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48060005
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45450394
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44524409
55P300_19829295_ChIP-Seq_ESCs_Human1.42461827
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.42098973
57* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.41461867
58NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.41218402
59TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.40997744
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.40120938
61REST_21632747_ChIP-Seq_MESCs_Mouse1.39661917
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.39549779
63VDR_22108803_ChIP-Seq_LS180_Human1.38766707
64POU5F1_16518401_ChIP-PET_MESCs_Mouse1.38138525
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.38040328
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37054357
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36109536
68FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33187848
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31226124
70STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29603049
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29410821
72RNF2_27304074_Chip-Seq_NSC_Mouse1.26959609
73AR_21572438_ChIP-Seq_LNCaP_Human1.26408250
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26340332
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25107671
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24465113
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23018100
78ETS1_20019798_ChIP-Seq_JURKAT_Human1.22560401
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21893931
80ZNF274_21170338_ChIP-Seq_K562_Hela1.21880498
81ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21471627
82* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18541821
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18189791
84E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17959836
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17859349
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17678301
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17176965
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16535717
89JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15521969
90* NANOG_16518401_ChIP-PET_MESCs_Mouse1.15324016
91AR_21909140_ChIP-Seq_LNCAP_Human1.15103938
92REST_18959480_ChIP-ChIP_MESCs_Mouse1.14809824
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14364772
94TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14275767
95* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14035616
96* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.13542141
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13458415
98NANOG_21062744_ChIP-ChIP_HESCs_Human1.13079805
99TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12855543
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12610006
101SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12473283
102SOX9_26525672_Chip-Seq_HEART_Mouse1.12139369
103MYC_18940864_ChIP-ChIP_HL60_Human1.12132244
104BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11831341
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11622860
106SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11556492
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11328280
108MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10703727
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.10046573
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08941246
111TTF2_22483619_ChIP-Seq_HELA_Human1.07260551
112* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.06378550
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05971173
114TAF15_26573619_Chip-Seq_HEK293_Human1.05950768
115ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05771913
116* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05678892
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05639696
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05175729
119JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05036364
120MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04179868
121PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.03559395
122EWS_26573619_Chip-Seq_HEK293_Human1.02820403
123ERG_21242973_ChIP-ChIP_JURKAT_Human1.02260187
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01970181
125* NANOG_16153702_ChIP-ChIP_HESCs_Human1.01729818
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01239079
127RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00835346
128CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00801954
129* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00755568
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00494497
131RING1B_27294783_Chip-Seq_NPCs_Mouse0.99077609
132WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97839239
133GATA1_26923725_Chip-Seq_HPCs_Mouse0.97735186
134NANOG_18555785_Chip-Seq_ESCs_Mouse0.96909351
135JUN_21703547_ChIP-Seq_K562_Human0.96408095
136EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96166334
137RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96166334
138TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96112787
139* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95658785
140E2F1_21310950_ChIP-Seq_MCF-7_Human0.95428034
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95419980
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95089940
143KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95072978
144STAT3_23295773_ChIP-Seq_U87_Human0.94638534
145TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93871458
146CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93177494
147NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93126057
148RNF2_27304074_Chip-Seq_ESCs_Mouse0.93029829
149TAL1_26923725_Chip-Seq_HPCs_Mouse0.92628854
150UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91838597
151SMAD4_21799915_ChIP-Seq_A2780_Human0.91801835
152* CBX2_27304074_Chip-Seq_ESCs_Mouse0.91692295
153SOX2_21211035_ChIP-Seq_LN229_Gbm0.91303466
154NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90205875
155CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89596281
156JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89479953
157THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89167132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.45120297
2MP0002822_catalepsy3.02984876
3MP0003121_genomic_imprinting2.96072466
4MP0003123_paternal_imprinting2.76503214
5MP0004859_abnormal_synaptic_plasticity2.73790735
6MP0003880_abnormal_central_pattern2.68294271
7MP0003787_abnormal_imprinting2.34080860
8MP0005423_abnormal_somatic_nervous2.23163650
9MP0001529_abnormal_vocalization2.22786373
10MP0002653_abnormal_ependyma_morphology2.22027110
11MP0008058_abnormal_DNA_repair2.15253954
12MP0003635_abnormal_synaptic_transmissio2.09315433
13MP0002638_abnormal_pupillary_reflex2.01955977
14MP0002063_abnormal_learning/memory/cond1.92863139
15MP0000778_abnormal_nervous_system1.92627423
16MP0004270_analgesia1.87719073
17MP0010030_abnormal_orbit_morphology1.85833164
18MP0004133_heterotaxia1.84257919
19MP0009745_abnormal_behavioral_response1.66602870
20MP0003119_abnormal_digestive_system1.65649282
21MP0003693_abnormal_embryo_hatching1.55432728
22MP0006276_abnormal_autonomic_nervous1.54759585
23MP0002572_abnormal_emotion/affect_behav1.52312447
24MP0001486_abnormal_startle_reflex1.50331687
25MP0002102_abnormal_ear_morphology1.42895700
26MP0000537_abnormal_urethra_morphology1.41400655
27MP0009046_muscle_twitch1.40008656
28MP0002064_seizures1.39797544
29MP0005623_abnormal_meninges_morphology1.38446641
30MP0002697_abnormal_eye_size1.37453372
31MP0003861_abnormal_nervous_system1.36545465
32MP0005248_abnormal_Harderian_gland1.34710953
33MP0002184_abnormal_innervation1.33496999
34MP0002009_preneoplasia1.33415920
35MP0004197_abnormal_fetal_growth/weight/1.33247349
36MP0002084_abnormal_developmental_patter1.30367248
37MP0003283_abnormal_digestive_organ1.28887578
38MP0005646_abnormal_pituitary_gland1.26341040
39MP0002282_abnormal_trachea_morphology1.22420608
40MP0000631_abnormal_neuroendocrine_gland1.22291961
41MP0003890_abnormal_embryonic-extraembry1.18310091
42MP0002152_abnormal_brain_morphology1.18153357
43MP0004885_abnormal_endolymph1.17864097
44MP0000955_abnormal_spinal_cord1.15819851
45MP0004215_abnormal_myocardial_fiber1.14437950
46MP0005386_behavior/neurological_phenoty1.14095649
47MP0004924_abnormal_behavior1.14095649
48MP0002734_abnormal_mechanical_nocicepti1.13368301
49MP0002557_abnormal_social/conspecific_i1.13240322
50MP0008995_early_reproductive_senescence1.12647446
51MP0001293_anophthalmia1.12496369
52MP0010234_abnormal_vibrissa_follicle1.11221715
53MP0005367_renal/urinary_system_phenotyp1.10689446
54MP0000516_abnormal_urinary_system1.10689446
55MP0005499_abnormal_olfactory_system1.10612461
56MP0005394_taste/olfaction_phenotype1.10612461
57MP0002909_abnormal_adrenal_gland1.09366489
58MP0004811_abnormal_neuron_physiology1.08503530
59MP0002751_abnormal_autonomic_nervous1.08279841
60MP0002249_abnormal_larynx_morphology1.07956778
61MP0002210_abnormal_sex_determination1.07549981
62MP0004957_abnormal_blastocyst_morpholog1.07474658
63MP0001188_hyperpigmentation1.05679235
64MP0002733_abnormal_thermal_nociception1.05303809
65MP0002085_abnormal_embryonic_tissue1.04991733
66MP0002938_white_spotting1.04916940
67MP0000569_abnormal_digit_pigmentation1.04777975
68MP0002234_abnormal_pharynx_morphology1.04704509
69MP0004858_abnormal_nervous_system1.04582592
70MP0006035_abnormal_mitochondrial_morpho1.03547965
71MP0003385_abnormal_body_wall1.03140052
72MP0003937_abnormal_limbs/digits/tail_de1.02670661
73MP0005253_abnormal_eye_physiology1.02257753
74MP0000534_abnormal_ureter_morphology1.02198690
75MP0000751_myopathy1.01439215
76MP0003136_yellow_coat_color1.00115385
77MP0002272_abnormal_nervous_system0.99975462
78MP0001968_abnormal_touch/_nociception0.99672196
79MP0001929_abnormal_gametogenesis0.99249872
80MP0009697_abnormal_copulation0.99221856
81MP0003755_abnormal_palate_morphology0.98473892
82MP0001730_embryonic_growth_arrest0.98191567
83MP0006072_abnormal_retinal_apoptosis0.98115233
84MP0003111_abnormal_nucleus_morphology0.97850343
85MP0004233_abnormal_muscle_weight0.97490425
86MP0000049_abnormal_middle_ear0.96762988
87MP0002332_abnormal_exercise_endurance0.96642898
88MP0003698_abnormal_male_reproductive0.95943550
89MP0010094_abnormal_chromosome_stability0.95505831
90MP0001286_abnormal_eye_development0.94684516
91MP0002160_abnormal_reproductive_system0.94164560
92MP0008057_abnormal_DNA_replication0.92970347
93MP0002882_abnormal_neuron_morphology0.92682977
94MP0002735_abnormal_chemical_nociception0.92065683
95MP0000653_abnormal_sex_gland0.91978253
96MP0001145_abnormal_male_reproductive0.91016782
97MP0005391_vision/eye_phenotype0.90658219
98MP0001672_abnormal_embryogenesis/_devel0.89352895
99MP0005380_embryogenesis_phenotype0.89352895
100MP0001440_abnormal_grooming_behavior0.89110872
101MP0002086_abnormal_extraembryonic_tissu0.88999046
102MP0000647_abnormal_sebaceous_gland0.88995245
103MP0008789_abnormal_olfactory_epithelium0.88533838
104MP0001270_distended_abdomen0.88526202
105MP0003942_abnormal_urinary_system0.88152028
106MP0003077_abnormal_cell_cycle0.88128767
107MP0000013_abnormal_adipose_tissue0.87836798
108MP0001984_abnormal_olfaction0.87827328
109MP0002752_abnormal_somatic_nervous0.87454936
110MP0002081_perinatal_lethality0.86141592
111MP0002233_abnormal_nose_morphology0.86118599
112MP0005645_abnormal_hypothalamus_physiol0.85147219
113MP0001697_abnormal_embryo_size0.85141428
114MP0003935_abnormal_craniofacial_develop0.84554452
115MP0005503_abnormal_tendon_morphology0.84220765
116MP0000350_abnormal_cell_proliferation0.84184019
117MP0006292_abnormal_olfactory_placode0.83175247
118MP0008877_abnormal_DNA_methylation0.82526059
119MP0002092_abnormal_eye_morphology0.82105609
120MP0004272_abnormal_basement_membrane0.81875053
121MP0003567_abnormal_fetal_cardiomyocyte0.81642462
122MP0010386_abnormal_urinary_bladder0.81616036
123MP0002116_abnormal_craniofacial_bone0.80680612
124MP0008932_abnormal_embryonic_tissue0.80328166
125MP0009703_decreased_birth_body0.80324165
126MP0003115_abnormal_respiratory_system0.80152777
127MP0001177_atelectasis0.79876889
128MP0005187_abnormal_penis_morphology0.79833068
129MP0003941_abnormal_skin_development0.79824232
130MP0004085_abnormal_heartbeat0.79307839
131MP0001299_abnormal_eye_distance/0.79056968
132MP0002066_abnormal_motor_capabilities/c0.79031079
133MP0000579_abnormal_nail_morphology0.79008767
134MP0004084_abnormal_cardiac_muscle0.76336376
135MP0009250_abnormal_appendicular_skeleto0.76195034
136MP0000566_synostosis0.75342072

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.26627702
2Ependymoma (HP:0002888)3.50776732
3Astrocytoma (HP:0009592)3.11200696
4Abnormality of the astrocytes (HP:0100707)3.11200696
5Cortical dysplasia (HP:0002539)2.85424686
6Calcaneovalgus deformity (HP:0001848)2.57114006
7Occipital encephalocele (HP:0002085)2.52640059
8Genital tract atresia (HP:0001827)2.51091365
9Limb dystonia (HP:0002451)2.48629394
10Vaginal atresia (HP:0000148)2.47914676
11Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.47117259
12Neoplasm of the oral cavity (HP:0100649)2.47056772
13Hepatoblastoma (HP:0002884)2.45179471
14Nephrogenic diabetes insipidus (HP:0009806)2.44455498
15Congenital primary aphakia (HP:0007707)2.44208638
16Intestinal atresia (HP:0011100)2.42732168
17Deformed tarsal bones (HP:0008119)2.41304206
18High anterior hairline (HP:0009890)2.40362987
19Volvulus (HP:0002580)2.40234763
20Myokymia (HP:0002411)2.38930074
21Medulloblastoma (HP:0002885)2.37268261
22Supernumerary spleens (HP:0009799)2.36615122
23Hyperglycinemia (HP:0002154)2.32149304
24Medial flaring of the eyebrow (HP:0010747)2.26414362
25Abnormality of the lower motor neuron (HP:0002366)2.26285785
26Glioma (HP:0009733)2.26169852
27Vitreoretinal degeneration (HP:0000655)2.22828993
28Oligodactyly (HP:0012165)2.22827266
29Abnormality of the corticospinal tract (HP:0002492)2.18249169
30Missing ribs (HP:0000921)2.15761744
31Shawl scrotum (HP:0000049)2.11813188
32Pheochromocytoma (HP:0002666)2.10434982
33Rimmed vacuoles (HP:0003805)2.08129294
34Focal seizures (HP:0007359)2.07909852
35Mild short stature (HP:0003502)2.05889128
36Abnormality of alanine metabolism (HP:0010916)2.05719327
37Hyperalaninemia (HP:0003348)2.05719327
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05719327
39Colon cancer (HP:0003003)2.04202476
40Focal motor seizures (HP:0011153)2.01279015
41Short tibia (HP:0005736)2.01178699
42Anophthalmia (HP:0000528)1.96011669
43Shoulder girdle muscle weakness (HP:0003547)1.94086948
44Cutaneous finger syndactyly (HP:0010554)1.93525918
45Resting tremor (HP:0002322)1.92285785
46Relative macrocephaly (HP:0004482)1.91410965
47Cerebral edema (HP:0002181)1.91004839
48Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90528207
49Degeneration of the lateral corticospinal tracts (HP:0002314)1.90528207
50Cutaneous syndactyly (HP:0012725)1.90365337
51Thyroid carcinoma (HP:0002890)1.88796701
52Esophageal atresia (HP:0002032)1.88614125
53Methylmalonic acidemia (HP:0002912)1.87086941
54Neuroendocrine neoplasm (HP:0100634)1.86333350
55Short humerus (HP:0005792)1.85621036
56Abnormality of abdominal situs (HP:0011620)1.85504553
57Abdominal situs inversus (HP:0003363)1.85504553
58Amyotrophic lateral sclerosis (HP:0007354)1.85339720
59Aplasia/Hypoplasia of the tibia (HP:0005772)1.83890046
60Retinal dysplasia (HP:0007973)1.83555098
61Chronic hepatic failure (HP:0100626)1.83503784
62Rhabdomyosarcoma (HP:0002859)1.83011089
63Aplasia/hypoplasia of the humerus (HP:0006507)1.82998377
64Cerebellar dysplasia (HP:0007033)1.81614554
65Neoplasm of striated muscle (HP:0009728)1.81360417
66Synostosis involving the elbow (HP:0003938)1.80673612
67Humeroradial synostosis (HP:0003041)1.80673612
68Progressive cerebellar ataxia (HP:0002073)1.78828616
69Rib fusion (HP:0000902)1.78751987
70Bicornuate uterus (HP:0000813)1.77967290
71Angiofibromas (HP:0010615)1.77239907
72Adenoma sebaceum (HP:0009720)1.77239907
73Specific learning disability (HP:0001328)1.76966282
74Increased serum pyruvate (HP:0003542)1.75724870
75Embryonal renal neoplasm (HP:0011794)1.73634035
76Abnormality of serum amino acid levels (HP:0003112)1.73237970
77Abnormal lung lobation (HP:0002101)1.73161376
78Aplasia/Hypoplasia of the brainstem (HP:0007362)1.72295644
79Hypoplasia of the brainstem (HP:0002365)1.72295644
80Exotropia (HP:0000577)1.71945539
81Short foot (HP:0001773)1.71725571
82Abnormality of the calcaneus (HP:0008364)1.71363840
83Poor coordination (HP:0002370)1.70442360
84Nephroblastoma (Wilms tumor) (HP:0002667)1.70430049
85Increased nuchal translucency (HP:0010880)1.70376242
86Abnormal number of incisors (HP:0011064)1.70259977
87Broad foot (HP:0001769)1.69643308
88Abnormality of the parathyroid morphology (HP:0011766)1.69211071
89Distal arthrogryposis (HP:0005684)1.68438731
90Urinary urgency (HP:0000012)1.68410084
91Aplasia/Hypoplasia of the sternum (HP:0006714)1.68258864
92Lissencephaly (HP:0001339)1.65769329
93Nephronophthisis (HP:0000090)1.65435366
94Oligodactyly (hands) (HP:0001180)1.65188160
95Absent forearm bone (HP:0003953)1.65165591
96Aplasia involving forearm bones (HP:0009822)1.65165591
97Broad-based gait (HP:0002136)1.64054296
98Fetal akinesia sequence (HP:0001989)1.63496540
99Irregular epiphyses (HP:0010582)1.63189360
100Failure to thrive in infancy (HP:0001531)1.62778819
101Neuroblastic tumors (HP:0004376)1.62211196
102Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.62211196
103Neuroblastoma (HP:0003006)1.62211196
104Primitive neuroectodermal tumor (HP:0030065)1.62211196
105Papillary thyroid carcinoma (HP:0002895)1.61768965
106Postaxial hand polydactyly (HP:0001162)1.61758511
107Impaired vibration sensation in the lower limbs (HP:0002166)1.60694289
108Pointed chin (HP:0000307)1.60462441
109Acute necrotizing encephalopathy (HP:0006965)1.60331835
110Abnormal mitochondria in muscle tissue (HP:0008316)1.59506416
111Selective tooth agenesis (HP:0001592)1.59319219
112Gastroesophageal reflux (HP:0002020)1.58385074
113Abnormality of the pubic bones (HP:0003172)1.58149536
114Metaphyseal cupping (HP:0003021)1.57833943
115Patellar aplasia (HP:0006443)1.57062518
116Tubulointerstitial nephritis (HP:0001970)1.56666394
117Epiphyseal dysplasia (HP:0002656)1.56559487
118Pancreatic fibrosis (HP:0100732)1.56483721
119Wrist flexion contracture (HP:0001239)1.56048766
120Hypothermia (HP:0002045)1.54532489
121Sex reversal (HP:0012245)1.54146997
122Abnormal sex determination (HP:0012244)1.54146997
123Annular pancreas (HP:0001734)1.53861191
124Abnormality of the diencephalon (HP:0010662)1.53741744
125Renal dysplasia (HP:0000110)1.53579620
126Absent radius (HP:0003974)1.52385991
127Hypoplastic ischia (HP:0003175)1.52346504
128Abnormality of glycolysis (HP:0004366)1.52164112
129Amblyopia (HP:0000646)1.51616296
130Thin ribs (HP:0000883)1.51030311
131Adducted thumb (HP:0001181)1.50089361
132Benign neoplasm of the central nervous system (HP:0100835)1.49847800
133Ankyloglossia (HP:0010296)1.49828867
134Symphalangism affecting the phalanges of the hand (HP:0009773)1.49737182
135Intestinal polyposis (HP:0200008)1.49578160
136Poor suck (HP:0002033)1.49406542
137Atrophy/Degeneration involving motor neurons (HP:0007373)1.48736643
138Gastrointestinal atresia (HP:0002589)1.48512704
139Scanning speech (HP:0002168)1.48343113
140Acute encephalopathy (HP:0006846)1.47907984
141Gait imbalance (HP:0002141)1.47605324
142Proximal tubulopathy (HP:0000114)1.47351949
143Visual hallucinations (HP:0002367)1.47280706
144Diastasis recti (HP:0001540)1.47186126
145Malignant neoplasm of the central nervous system (HP:0100836)1.46696717
146Abnormality of the phalanges of the 2nd finger (HP:0009541)1.46649265
147Hypsarrhythmia (HP:0002521)1.46537242
148Septo-optic dysplasia (HP:0100842)1.45983576
149Abnormality of midbrain morphology (HP:0002418)1.45749942
150Molar tooth sign on MRI (HP:0002419)1.45749942
151Labial hypoplasia (HP:0000066)1.45624723
152Intestinal polyp (HP:0005266)1.45363580
153Split foot (HP:0001839)1.44516832
154Osteomalacia (HP:0002749)1.44232594
155Chromsome breakage (HP:0040012)1.44138857
156Vertebral hypoplasia (HP:0008417)1.44126829
157Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.44126829
158Vertebral clefting (HP:0008428)1.43854185
159Bilateral microphthalmos (HP:0007633)1.43596476
160Neoplasm of the heart (HP:0100544)1.43536747
161Atonic seizures (HP:0010819)1.43383311
162Aplasia/Hypoplasia of the patella (HP:0006498)1.43138837
163Biliary tract neoplasm (HP:0100574)1.42939436
164Drooling (HP:0002307)1.42802991
165Excessive salivation (HP:0003781)1.42802991
166Flat capital femoral epiphysis (HP:0003370)1.42454520
167Malignant gastrointestinal tract tumors (HP:0006749)1.42216179
168Gastrointestinal carcinoma (HP:0002672)1.42216179
169Micropenis (HP:0000054)1.42050293
170Termporal pattern (HP:0011008)1.41722046
171Insidious onset (HP:0003587)1.41722046
172Cystic hygroma (HP:0000476)1.41319452

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KSR12.63209642
2EPHA42.58030046
3MAP3K92.56489823
4MARK12.53491257
5PDK22.47360319
6PNCK2.44805528
7NEK12.35757171
8NTRK22.33119663
9MAP3K42.28240547
10NTRK32.07717871
11PBK2.07103778
12TRIM281.94323048
13WNK31.94078570
14CSNK1A1L1.92344367
15BCR1.90942905
16FGFR21.90324609
17PLK41.88778539
18AKT31.86186394
19CASK1.85270085
20TYRO31.85082790
21LATS21.71086859
22PLK21.69430175
23MINK11.68157542
24PLK31.67668150
25EPHA21.66250670
26MKNK11.65496412
27CDC71.53420842
28TSSK61.52342651
29MAPK131.46279218
30ZAK1.39638566
31CCNB11.38053130
32ERBB41.33815060
33BRSK21.33358730
34DYRK21.30971125
35PRKD31.28985612
36UHMK11.25771274
37CDK191.25062385
38KSR21.24140213
39PINK11.23039443
40BMPR1B1.22865858
41CDK121.18437638
42WEE11.16808405
43LIMK11.15677272
44MAP4K21.14619253
45MAP2K71.14417103
46MKNK21.12387656
47SIK31.10468423
48BRSK11.10167551
49BCKDK1.09798333
50PAK61.09509143
51ERBB31.08695540
52SCYL21.07213247
53STK161.04199678
54RPS6KB21.02226930
55OBSCN1.00834248
56SRPK11.00820950
57FER0.98897265
58STK390.96476519
59CDK180.95424010
60ICK0.95130381
61PDGFRA0.95119714
62STK38L0.94669880
63FGFR10.92287723
64TNIK0.91314318
65CDK140.88361434
66MAP2K40.86518295
67TTK0.86470436
68DDR20.84756948
69TAF10.84702058
70CSNK1G20.84693192
71TGFBR10.84585881
72CDK150.84290037
73BRAF0.82665566
74MET0.82630581
75CSNK1G30.82619270
76PLK10.81897980
77ATR0.81706207
78ALK0.80865577
79DYRK30.80237252
80PAK30.79143688
81MAPKAPK50.78895159
82CHEK20.78708830
83OXSR10.77896801
84CDK30.76330069
85VRK10.74682195
86BRD40.74077133
87CDK50.72122889
88CDK11A0.70484933
89NTRK10.69824825
90CSNK1E0.69695202
91AURKA0.69361910
92CHEK10.68868378
93PRKCE0.68814111
94PRKCG0.68387418
95ARAF0.66979090
96ROCK10.66531193
97BUB10.64308047
98CSNK1D0.61361352
99AURKB0.59424262
100PASK0.58729115
101CDK20.58307749
102SGK20.57588486
103ROCK20.56843374
104CDK10.56010708
105MAP3K50.55734024
106MAPK100.55699747
107PIM20.53716374
108CDK80.53695340
109CSNK1G10.53322266
110ACVR1B0.52802791
111YES10.52747970
112ADRBK10.52647669
113NME10.51558069
114SGK2230.51041708
115SGK4940.51041708
116PRKCI0.50628338
117PHKG10.49963218
118PHKG20.49963218
119GRK50.49743079
120MAP2K10.49527507
121DAPK10.49279344
122RET0.48995702
123MAP3K120.48519566
124PRKACB0.48427767
125SIK20.47976561
126AKT20.47873663
127ATM0.47038358
128PKN10.46545803
129RAF10.46459594
130DYRK1A0.46366010
131LATS10.46214136
132CAMK2A0.45030910
133CAMK2B0.44630021
134EEF2K0.44591227
135DYRK1B0.43818446
136PRKDC0.43471300
137NEK20.43233795
138MAPKAPK30.43078509
139ERBB20.42364188
140GSK3B0.41935970
141PDK30.41892504
142CAMK2D0.40950244
143RPS6KB10.40525996
144CDK60.36754191
145TIE10.35056151

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.86715885
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26787233
3Non-homologous end-joining_Homo sapiens_hsa034502.25700843
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19981796
5Synaptic vesicle cycle_Homo sapiens_hsa047212.05353540
6GABAergic synapse_Homo sapiens_hsa047271.98381741
7Protein export_Homo sapiens_hsa030601.87607316
8Amphetamine addiction_Homo sapiens_hsa050311.84523468
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.82640059
10Cocaine addiction_Homo sapiens_hsa050301.79516729
11RNA transport_Homo sapiens_hsa030131.79061879
12Dopaminergic synapse_Homo sapiens_hsa047281.79005890
13Base excision repair_Homo sapiens_hsa034101.78483916
14Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.78313753
15Long-term potentiation_Homo sapiens_hsa047201.77195965
16Oocyte meiosis_Homo sapiens_hsa041141.75996404
17Hippo signaling pathway_Homo sapiens_hsa043901.72593443
18Propanoate metabolism_Homo sapiens_hsa006401.71453407
19mRNA surveillance pathway_Homo sapiens_hsa030151.71396411
20Olfactory transduction_Homo sapiens_hsa047401.64368038
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.61908674
22Axon guidance_Homo sapiens_hsa043601.60207339
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57151288
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56071388
25Alcoholism_Homo sapiens_hsa050341.55570356
26Gap junction_Homo sapiens_hsa045401.54825231
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54489057
28Morphine addiction_Homo sapiens_hsa050321.51970065
29Mismatch repair_Homo sapiens_hsa034301.48909413
30* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.47052115
31Spliceosome_Homo sapiens_hsa030401.44874540
32Glutamatergic synapse_Homo sapiens_hsa047241.42960601
33Circadian entrainment_Homo sapiens_hsa047131.42016001
34Hedgehog signaling pathway_Homo sapiens_hsa043401.41435914
35Oxidative phosphorylation_Homo sapiens_hsa001901.38575499
36Serotonergic synapse_Homo sapiens_hsa047261.38495311
37Long-term depression_Homo sapiens_hsa047301.37441649
38Homologous recombination_Homo sapiens_hsa034401.37241242
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37145102
40Basal cell carcinoma_Homo sapiens_hsa052171.33721979
41Pyruvate metabolism_Homo sapiens_hsa006201.32700897
42Fatty acid elongation_Homo sapiens_hsa000621.32637287
43Steroid biosynthesis_Homo sapiens_hsa001001.32320800
44Cell cycle_Homo sapiens_hsa041101.30636998
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30193607
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27264466
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27027209
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23591686
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21240056
50Colorectal cancer_Homo sapiens_hsa052101.20717320
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19550811
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17661463
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16572797
54Tight junction_Homo sapiens_hsa045301.16566389
55Cholinergic synapse_Homo sapiens_hsa047251.15442003
56Carbon metabolism_Homo sapiens_hsa012001.14102200
57Oxytocin signaling pathway_Homo sapiens_hsa049211.12267434
58Cardiac muscle contraction_Homo sapiens_hsa042601.10366123
59Melanogenesis_Homo sapiens_hsa049161.08934602
60One carbon pool by folate_Homo sapiens_hsa006701.08788759
61Nucleotide excision repair_Homo sapiens_hsa034201.06427422
62Taste transduction_Homo sapiens_hsa047421.06340904
63Wnt signaling pathway_Homo sapiens_hsa043101.05112535
64ErbB signaling pathway_Homo sapiens_hsa040121.04516249
65Dilated cardiomyopathy_Homo sapiens_hsa054141.02723680
66Endometrial cancer_Homo sapiens_hsa052131.02417175
67Butanoate metabolism_Homo sapiens_hsa006501.01898657
68Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00499680
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00099404
70Glioma_Homo sapiens_hsa052141.00007645
71RNA degradation_Homo sapiens_hsa030180.99189277
72Alzheimers disease_Homo sapiens_hsa050100.98579141
73Arginine biosynthesis_Homo sapiens_hsa002200.94855588
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.94538070
75mTOR signaling pathway_Homo sapiens_hsa041500.93558903
76MicroRNAs in cancer_Homo sapiens_hsa052060.92110398
77TGF-beta signaling pathway_Homo sapiens_hsa043500.91613055
78Insulin secretion_Homo sapiens_hsa049110.91498508
79Calcium signaling pathway_Homo sapiens_hsa040200.91067434
80Nitrogen metabolism_Homo sapiens_hsa009100.90390463
81Estrogen signaling pathway_Homo sapiens_hsa049150.89345830
82Pyrimidine metabolism_Homo sapiens_hsa002400.89031987
83Renin secretion_Homo sapiens_hsa049240.88170827
84Vibrio cholerae infection_Homo sapiens_hsa051100.87432095
85Purine metabolism_Homo sapiens_hsa002300.87121210
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86758093
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86541663
88Fatty acid metabolism_Homo sapiens_hsa012120.85064515
89Basal transcription factors_Homo sapiens_hsa030220.84776993
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83969000
91Salivary secretion_Homo sapiens_hsa049700.82620353
92GnRH signaling pathway_Homo sapiens_hsa049120.82451609
93Renal cell carcinoma_Homo sapiens_hsa052110.82296609
94Adherens junction_Homo sapiens_hsa045200.81959938
95Parkinsons disease_Homo sapiens_hsa050120.81704721
96RNA polymerase_Homo sapiens_hsa030200.80989173
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.79978822
98Thyroid cancer_Homo sapiens_hsa052160.79775562
99Huntingtons disease_Homo sapiens_hsa050160.78843397
100Melanoma_Homo sapiens_hsa052180.78160731
101Selenocompound metabolism_Homo sapiens_hsa004500.77922075
102Proteasome_Homo sapiens_hsa030500.77447104
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75800242
104Vitamin B6 metabolism_Homo sapiens_hsa007500.75509384
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74238895
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73472515
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73047333
108Bladder cancer_Homo sapiens_hsa052190.72829247
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69273681
110Rap1 signaling pathway_Homo sapiens_hsa040150.67616340
111cAMP signaling pathway_Homo sapiens_hsa040240.66972353
112Gastric acid secretion_Homo sapiens_hsa049710.66365107
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.65672217
114Collecting duct acid secretion_Homo sapiens_hsa049660.64930670
115Glutathione metabolism_Homo sapiens_hsa004800.64490546
116Non-small cell lung cancer_Homo sapiens_hsa052230.63927639
117Peroxisome_Homo sapiens_hsa041460.60123139
118Prion diseases_Homo sapiens_hsa050200.59014722
119DNA replication_Homo sapiens_hsa030300.58803226
120Focal adhesion_Homo sapiens_hsa045100.58280450
121Fanconi anemia pathway_Homo sapiens_hsa034600.58237608
122Dorso-ventral axis formation_Homo sapiens_hsa043200.57592780
123Regulation of autophagy_Homo sapiens_hsa041400.56380064
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55992058
125Biosynthesis of amino acids_Homo sapiens_hsa012300.55191782
126Metabolic pathways_Homo sapiens_hsa011000.54397209
127Arginine and proline metabolism_Homo sapiens_hsa003300.53976179
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53734745
129beta-Alanine metabolism_Homo sapiens_hsa004100.53653683
130Pathways in cancer_Homo sapiens_hsa052000.53448186
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52756210
132Choline metabolism in cancer_Homo sapiens_hsa052310.51554020
133Phototransduction_Homo sapiens_hsa047440.50988986
134Type I diabetes mellitus_Homo sapiens_hsa049400.50775416
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.49927502
136Proteoglycans in cancer_Homo sapiens_hsa052050.48651384
137ECM-receptor interaction_Homo sapiens_hsa045120.48466346
138Systemic lupus erythematosus_Homo sapiens_hsa053220.47724687
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47406006
140Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47106506
141Circadian rhythm_Homo sapiens_hsa047100.46312158
142Fatty acid degradation_Homo sapiens_hsa000710.43621330
143N-Glycan biosynthesis_Homo sapiens_hsa005100.42621533
144Glucagon signaling pathway_Homo sapiens_hsa049220.40931895

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