KLHL10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain a BACK domain and six C-terminal kelch repeats. Kelch domains are thought to form a four stranded beta-sheet blade structure that can fold into a beta-propeller domain when multiple kelch repeats are found together. Mutations in this gene have been associated with oligozoospermia in some infertile males. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.87608170
2plasma membrane fusion (GO:0045026)9.85440347
3axonemal dynein complex assembly (GO:0070286)9.77902598
4epithelial cilium movement (GO:0003351)9.54475309
5cilium or flagellum-dependent cell motility (GO:0001539)9.09950235
6* spermatid development (GO:0007286)9.08555508
7motile cilium assembly (GO:0044458)8.82248375
8reproduction (GO:0000003)8.66237926
9regulation of cilium movement (GO:0003352)8.46901723
10response to pheromone (GO:0019236)8.21142921
11cilium movement (GO:0003341)7.76800567
12cellular ketone body metabolic process (GO:0046950)7.55118472
13synaptonemal complex organization (GO:0070193)7.30784033
14synaptonemal complex assembly (GO:0007130)7.24687143
15rRNA methylation (GO:0031167)7.10980475
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.09301654
17phosphatidylethanolamine biosynthetic process (GO:0006646)7.03695946
18piRNA metabolic process (GO:0034587)6.95894261
19single fertilization (GO:0007338)6.92843668
20male meiosis (GO:0007140)6.83621656
21phosphatidylethanolamine metabolic process (GO:0046337)6.77570807
22sperm capacitation (GO:0048240)6.66008234
23ketone body metabolic process (GO:1902224)6.64436756
24microtubule depolymerization (GO:0007019)6.62795670
25negative regulation of inclusion body assembly (GO:0090084)6.61770737
26spermatogenesis (GO:0007283)6.37852654
27male gamete generation (GO:0048232)6.35752935
28rRNA modification (GO:0000154)6.24806187
29organic cation transport (GO:0015695)6.10910346
30gamete generation (GO:0007276)5.84340933
31* fertilization (GO:0009566)5.70071605
32regulation of inclusion body assembly (GO:0090083)5.64390765
33protein targeting to Golgi (GO:0000042)5.54069822
34establishment of protein localization to Golgi (GO:0072600)5.48140486
35male meiosis I (GO:0007141)5.29658058
36* cellular process involved in reproduction in multicellular organism (GO:0022412)5.13975753
37calcium ion-dependent exocytosis (GO:0017156)5.10039536
38retrograde transport, vesicle recycling within Golgi (GO:0000301)5.07524021
39* germ cell development (GO:0007281)5.04151763
40regulation of microtubule-based movement (GO:0060632)5.01228976
41chromosome organization involved in meiosis (GO:0070192)4.91726570
42chromosome condensation (GO:0030261)4.90653757
43ventricular system development (GO:0021591)4.87518243
44centriole replication (GO:0007099)4.84546432
45seminiferous tubule development (GO:0072520)4.79643936
46DNA packaging (GO:0006323)4.72226899
47regulation of Rab GTPase activity (GO:0032313)4.68679966
48positive regulation of Rab GTPase activity (GO:0032851)4.68679966
49cell recognition (GO:0008037)4.64536931
50meiosis I (GO:0007127)4.63670769
51microtubule severing (GO:0051013)4.63426343
52multicellular organismal reproductive process (GO:0048609)4.59013259
53meiotic nuclear division (GO:0007126)4.51350141
54DNA methylation involved in gamete generation (GO:0043046)4.48062740
55mating behavior (GO:0007617)4.47316386
56centriole assembly (GO:0098534)4.36134711
57spermatid nucleus differentiation (GO:0007289)4.34922887
58chromatin silencing (GO:0006342)4.29688699
59positive regulation of cGMP biosynthetic process (GO:0030828)4.27418896
60protein localization to Golgi apparatus (GO:0034067)4.26624103
61glycerol ether metabolic process (GO:0006662)4.22150194
62positive regulation of cGMP metabolic process (GO:0030825)4.16780845
63chaperone-mediated protein complex assembly (GO:0051131)4.14599232
64regulation of cGMP biosynthetic process (GO:0030826)4.10883341
65monoubiquitinated protein deubiquitination (GO:0035520)4.07964526
66left/right pattern formation (GO:0060972)4.03317223
67regulation of cGMP metabolic process (GO:0030823)3.96988232
68ether metabolic process (GO:0018904)3.89258748
69regulation of transcription involved in cell fate commitment (GO:0060850)3.84972761
70single strand break repair (GO:0000012)3.80999751
71coenzyme catabolic process (GO:0009109)3.78600274
72multicellular organismal movement (GO:0050879)3.75258060
73musculoskeletal movement (GO:0050881)3.75258060
74nucleosome disassembly (GO:0006337)3.66097533
75protein-DNA complex disassembly (GO:0032986)3.66097533
76regulation of spindle checkpoint (GO:0090231)3.64481959
77multicellular organismal development (GO:0007275)3.61174593
78meiotic cell cycle (GO:0051321)3.56760630
79peristalsis (GO:0030432)3.54759386
80sexual reproduction (GO:0019953)3.45518403
81response to acidic pH (GO:0010447)3.45284838
82protein polyglutamylation (GO:0018095)3.39082995
83microtubule polymerization or depolymerization (GO:0031109)3.38681143
84sequestering of actin monomers (GO:0042989)3.33690788
85nucleoside diphosphate phosphorylation (GO:0006165)3.29379864
86nucleus organization (GO:0006997)3.27018587
87negative regulation of Rho protein signal transduction (GO:0035024)3.24720760
88meiotic cell cycle process (GO:1903046)3.21804620
89polyamine biosynthetic process (GO:0006596)3.20923416
90protein refolding (GO:0042026)3.17794391
91protein K11-linked deubiquitination (GO:0035871)3.16959057
92RNA localization (GO:0006403)3.14641461
93interferon-gamma secretion (GO:0072643)3.14036423
94polyol catabolic process (GO:0046174)3.12638396
95GTP biosynthetic process (GO:0006183)3.12323735
96cellular response to pH (GO:0071467)3.07730270
97alditol metabolic process (GO:0019400)3.00202185
98regulation of phosphoprotein phosphatase activity (GO:0043666)2.97992625
99detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.97146488
100peptidyl-threonine dephosphorylation (GO:0035970)2.93027027
101membrane protein intracellular domain proteolysis (GO:0031293)2.92094719
102protein localization to chromosome, centromeric region (GO:0071459)2.88369633
103UTP biosynthetic process (GO:0006228)2.87206130
104protein localization to cilium (GO:0061512)2.86503151
105urinary tract smooth muscle contraction (GO:0014848)2.86396765
106mitotic sister chromatid cohesion (GO:0007064)2.85338896
107histone mRNA catabolic process (GO:0071044)2.84842931
108histone exchange (GO:0043486)2.83968772
109histone H3-K9 demethylation (GO:0033169)2.83199222
110carnitine transport (GO:0015879)2.79335633
111amino-acid betaine transport (GO:0015838)2.79335633
112axoneme assembly (GO:0035082)2.78398742
113cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.77832757
114cranial nerve morphogenesis (GO:0021602)2.74906407
115negative regulation of gene expression, epigenetic (GO:0045814)2.73427716
116guanosine-containing compound biosynthetic process (GO:1901070)2.68710060
117synapsis (GO:0007129)2.68115949
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.67596929
119cilium organization (GO:0044782)2.66033912
120microtubule-based movement (GO:0007018)2.65526169
121RNA destabilization (GO:0050779)2.64456236
122glycolytic process (GO:0006096)2.63577110
123carnitine transmembrane transport (GO:1902603)2.63410015
124gene silencing by RNA (GO:0031047)2.62602633
125mitochondrial fission (GO:0000266)2.60142035
126nuclear pore complex assembly (GO:0051292)2.57668740
127positive regulation of macrophage activation (GO:0043032)2.57463675
128NAD biosynthetic process (GO:0009435)2.57066750
129DNA conformation change (GO:0071103)2.56948592
130UTP metabolic process (GO:0046051)2.56675304
131cilium assembly (GO:0042384)2.54688905
132regulation of centriole replication (GO:0046599)2.54013773
133mitochondrion degradation (GO:0000422)2.53731477
134cilium morphogenesis (GO:0060271)2.52178300
135intraciliary transport (GO:0042073)2.51339661
136cellular component assembly involved in morphogenesis (GO:0010927)2.49526606
137sperm motility (GO:0030317)13.0562201
138fusion of sperm to egg plasma membrane (GO:0007342)12.9930476
139cell wall macromolecule metabolic process (GO:0044036)11.9462768
140cell wall macromolecule catabolic process (GO:0016998)11.9462768
141acrosome reaction (GO:0007340)11.1744071
142sperm-egg recognition (GO:0035036)11.0546592
143acrosome assembly (GO:0001675)10.7523994
144binding of sperm to zona pellucida (GO:0007339)10.1907699
145multicellular organism reproduction (GO:0032504)10.1501493

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.83204628
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.35851591
3EZH2_22144423_ChIP-Seq_EOC_Human3.24670088
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.20899573
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.89949324
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.80751949
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.76582721
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.74541244
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.72208478
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.70668033
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64482197
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.63068133
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.39755160
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.11982058
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.11541588
16VDR_22108803_ChIP-Seq_LS180_Human2.02892312
17ZNF274_21170338_ChIP-Seq_K562_Hela2.01340217
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.4962559
19EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.97848672
20FUS_26573619_Chip-Seq_HEK293_Human1.97798175
21RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.96094972
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92360753
23ER_23166858_ChIP-Seq_MCF-7_Human1.90918220
24VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.90230283
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.86148618
26FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82955147
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82173039
28KAP1_22055183_ChIP-Seq_ESCs_Mouse1.81434210
29TDRD3_21172665_ChIP-Seq_MCF-7_Human1.78664804
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74977879
31RAC3_21632823_ChIP-Seq_H3396_Human1.73938850
32ERA_21632823_ChIP-Seq_H3396_Human1.73126327
33CTCF_27219007_Chip-Seq_Bcells_Human1.72159641
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71362265
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70978614
36STAT1_17558387_ChIP-Seq_HELA_Human1.70859989
37KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.70358210
38AUTS2_25519132_ChIP-Seq_293T-REX_Human1.69904706
39E2F1_20622854_ChIP-Seq_HELA_Human1.68910003
40OCT4_20526341_ChIP-Seq_ESCs_Human1.68834639
41PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.64373021
42* GATA3_21867929_ChIP-Seq_CD8_Mouse1.63995171
43DROSHA_22980978_ChIP-Seq_HELA_Human1.63209159
44BCL6_27268052_Chip-Seq_Bcells_Human1.62992076
45ELK4_26923725_Chip-Seq_MESODERM_Mouse1.62125598
46TAF2_19829295_ChIP-Seq_ESCs_Human1.61319860
47SOX2_22085726_ChIP-Seq_NPCs_Mouse1.61109997
48TAF15_26573619_Chip-Seq_HEK293_Human1.55953238
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.55104043
50TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.52988924
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52589747
52GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.51175917
53WDR5_24793694_ChIP-Seq_LNCAP_Human1.50754413
54* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.49798477
55FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47808266
56TP53_18474530_ChIP-ChIP_U2OS_Human1.46701054
57AR_25329375_ChIP-Seq_VCAP_Human1.45634605
58P68_20966046_ChIP-Seq_HELA_Human1.45210532
59SMC4_20622854_ChIP-Seq_HELA_Human1.43847397
60P300_19829295_ChIP-Seq_ESCs_Human1.42597078
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42361569
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.41659057
63P300_27268052_Chip-Seq_Bcells_Human1.41255017
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40712575
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36053951
66SMAD4_21741376_ChIP-Seq_EPCs_Human1.35682007
67P53_21459846_ChIP-Seq_SAOS-2_Human1.34576781
68TP63_22573176_ChIP-Seq_HFKS_Human1.34549630
69ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34332936
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.33755906
71MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32935817
72LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.32834789
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.32559891
74GATA3_21867929_ChIP-Seq_TH1_Mouse1.29113819
75CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28617513
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28385265
77NANOG_19829295_ChIP-Seq_ESCs_Human1.27535281
78SOX2_19829295_ChIP-Seq_ESCs_Human1.27535281
79TAL1_26923725_Chip-Seq_HPCs_Mouse1.25937866
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.25795415
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.25031619
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24477058
83HOXB7_26014856_ChIP-Seq_BT474_Human1.24307198
84HNFA_21074721_ChIP-Seq_CACO-2_Human1.23514614
85CBP_20019798_ChIP-Seq_JUKART_Human1.23052650
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23052650
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.22966152
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22050950
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21806389
90RBPJ_21746931_ChIP-Seq_IB4_Human1.21716929
91SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21628150
92YY1_22570637_ChIP-Seq_MALME-3M_Human1.20809726
93CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.20010066
94TBL1_22424771_ChIP-Seq_293T_Human1.19593751
95RARA_24833708_ChIP-Seq_LIVER_Mouse1.18789100
96LXR_22292898_ChIP-Seq_THP-1_Human1.18606466
97SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.18411171
98FOXM1_23109430_ChIP-Seq_U2OS_Human1.18410336
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16821692
100RUNX2_22187159_ChIP-Seq_PCA_Human1.16736591
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16631450
102CBX2_22325352_ChIP-Seq_293T-Rex_Human1.16520475
103AR_21572438_ChIP-Seq_LNCaP_Human1.16387402
104SMAD4_21799915_ChIP-Seq_A2780_Human1.15400231
105SMRT_27268052_Chip-Seq_Bcells_Human1.14451617
106RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14050998
107TET1_21451524_ChIP-Seq_MESCs_Mouse1.13959367
108SMAD3_21741376_ChIP-Seq_ESCs_Human1.13479200
109GF1_26923725_Chip-Seq_HPCs_Mouse1.13430889
110SPI1_26923725_Chip-Seq_HPCs_Mouse1.13300051
111ERG_20517297_ChIP-Seq_VCAP_Human1.13197806
112ETV1_20927104_ChIP-Seq_GIST48_Human1.12890977
113RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11469411
114RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11337658
115NFYB_21822215_ChIP-Seq_K562_Human1.10814114
116STAT3_23295773_ChIP-Seq_U87_Human1.10745648
117CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10611853
118REST_21632747_ChIP-Seq_MESCs_Mouse1.09513033
119PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08581273
120KDM2B_26808549_Chip-Seq_REH_Human1.08530883
121P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.08352692
122SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08038747
123SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06609604
124CEBPB_22108803_ChIP-Seq_LS180_Human1.06028521
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05857723
126PHF8_20622853_ChIP-Seq_HELA_Human1.05725846
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05372134
128FLI1_21867929_ChIP-Seq_TH2_Mouse1.04398513
129ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03670880
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03666226
131OCT1_27270436_Chip-Seq_PROSTATE_Human1.03518429
132* FLI1_21867929_ChIP-Seq_CD8_Mouse1.02952157
133SPI1_20517297_ChIP-Seq_HL60_Human1.02582934
134LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02140182
135E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02053472
136KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.00760325
137FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00593356
138EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00543857
139RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00224381
140CRX_20693478_ChIP-Seq_RETINA_Mouse0.99588687
141CTCF_20526341_ChIP-Seq_ESCs_Human0.97899618
142SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97803606
143ESET_19884257_ChIP-Seq_ESCs_Mouse0.97544100
144PHF8_20622854_ChIP-Seq_HELA_Human0.96473511
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96367453
146SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95481431
147MYC_27129775_Chip-Seq_CORNEA_Mouse0.95229964
148ELF1_20517297_ChIP-Seq_JURKAT_Human0.94717747
149BCOR_27268052_Chip-Seq_Bcells_Human0.94060150
150JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.93707486
151SOX2_21211035_ChIP-Seq_LN229_Human0.91804579
152CBX2_27304074_Chip-Seq_ESCs_Mouse0.90152638
153CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89925755
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89360314
155POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89360314
156CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87976313
157NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87806622
158SOX11_22085726_ChIP-Seq_ESNs_Mouse0.87797894
159ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87182683
160CTCF_26484167_Chip-Seq_Bcells_Mouse0.86501427
161GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86231970
162NANOG_18555785_Chip-Seq_ESCs_Mouse0.85997089
163OCT4_18555785_Chip-Seq_ESCs_Mouse0.84817970
164SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83981394
165* NANOG_20526341_ChIP-Seq_ESCs_Human0.83963469
166TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82527832
167OCT4_21477851_ChIP-Seq_ESCs_Mouse0.82122241
168* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80907626
169STAT3_18555785_ChIP-Seq_MESCs_Mouse0.80855424
170MYC_19829295_ChIP-Seq_ESCs_Human0.80741131
171KLF4_18555785_Chip-Seq_ESCs_Mouse0.79690435

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.89510004
2* MP0001929_abnormal_gametogenesis5.46673874
3MP0008877_abnormal_DNA_methylation4.19063259
4* MP0002210_abnormal_sex_determination3.41279251
5* MP0002161_abnormal_fertility/fecundity3.27324997
6MP0005670_abnormal_white_adipose2.99511031
7* MP0001145_abnormal_male_reproductive2.95895232
8* MP0000653_abnormal_sex_gland2.57549721
9MP0002653_abnormal_ependyma_morphology2.36517905
10MP0001348_abnormal_lacrimal_gland2.34889735
11MP0003136_yellow_coat_color2.16428862
12MP0009053_abnormal_anal_canal2.09087041
13MP0005410_abnormal_fertilization15.7389259
14MP0002160_abnormal_reproductive_system1.85289116
15MP0005379_endocrine/exocrine_gland_phen1.73746061
16MP0003646_muscle_fatigue1.71855588
17MP0002822_catalepsy1.59368237
18MP0008058_abnormal_DNA_repair1.52659120
19MP0003111_abnormal_nucleus_morphology1.50580879
20MP0003787_abnormal_imprinting1.50136371
21MP0001968_abnormal_touch/_nociception1.48339355
22MP0005423_abnormal_somatic_nervous1.43189772
23MP0005367_renal/urinary_system_phenotyp1.40326969
24MP0000516_abnormal_urinary_system1.40326969
25MP0001502_abnormal_circadian_rhythm1.39738980
26MP0010094_abnormal_chromosome_stability1.38626015
27MP0005623_abnormal_meninges_morphology1.29070388
28MP0000678_abnormal_parathyroid_gland1.28502830
29MP0005646_abnormal_pituitary_gland1.27208199
30MP0004233_abnormal_muscle_weight1.23857944
31MP0003693_abnormal_embryo_hatching1.13300549
32MP0001879_abnormal_lymphatic_vessel1.13066831
33MP0009697_abnormal_copulation1.11071849
34MP0002127_abnormal_cardiovascular_syste1.10675898
35MP0001485_abnormal_pinna_reflex1.08053332
36MP0005389_reproductive_system_phenotype1.07314013
37MP0003878_abnormal_ear_physiology1.06334490
38MP0005377_hearing/vestibular/ear_phenot1.06334490
39MP0002249_abnormal_larynx_morphology1.05203620
40MP0005375_adipose_tissue_phenotype1.04366779
41MP0002282_abnormal_trachea_morphology1.03875530
42MP0005310_abnormal_salivary_gland1.02846810
43MP0002735_abnormal_chemical_nociception1.01806011
44MP0002254_reproductive_system_inflammat1.01798371
45MP0003786_premature_aging1.00013089
46MP0008057_abnormal_DNA_replication0.97458445
47MP0008995_early_reproductive_senescence0.96327083
48MP0000569_abnormal_digit_pigmentation0.94022815
49MP0001765_abnormal_ion_homeostasis0.93776602
50MP0003718_maternal_effect0.89683082
51MP0005174_abnormal_tail_pigmentation0.88600106
52MP0009780_abnormal_chondrocyte_physiolo0.86852894
53MP0003077_abnormal_cell_cycle0.85624903
54MP0000003_abnormal_adipose_tissue0.83515398
55MP0001986_abnormal_taste_sensitivity0.81548071
56MP0003879_abnormal_hair_cell0.80994065
57MP0005647_abnormal_sex_gland0.80876924
58MP0001905_abnormal_dopamine_level0.79661208
59MP0008007_abnormal_cellular_replicative0.78232433
60MP0004957_abnormal_blastocyst_morpholog0.78229889
61MP0001486_abnormal_startle_reflex0.77333969
62MP0005397_hematopoietic_system_phenotyp0.76711960
63MP0001545_abnormal_hematopoietic_system0.76711960
64MP0002234_abnormal_pharynx_morphology0.76410946
65MP0001730_embryonic_growth_arrest0.75640782
66MP0010329_abnormal_lipoprotein_level0.73888965
67MP0001984_abnormal_olfaction0.71868087
68MP0001661_extended_life_span0.71733495
69MP0002557_abnormal_social/conspecific_i0.71245592
70MP0000358_abnormal_cell_content/0.71201127
71MP0002837_dystrophic_cardiac_calcinosis0.71126123
72MP0001963_abnormal_hearing_physiology0.70645869
73MP0004484_altered_response_of0.69070663
74MP0001764_abnormal_homeostasis0.67932463
75MP0009046_muscle_twitch0.67778466
76MP0003699_abnormal_female_reproductive0.67256783
77MP0005636_abnormal_mineral_homeostasis0.67039966
78MP0003115_abnormal_respiratory_system0.65977500
79MP0002067_abnormal_sensory_capabilities0.65225327
80MP0001501_abnormal_sleep_pattern0.64839147
81MP0004381_abnormal_hair_follicle0.64245811
82MP0000372_irregular_coat_pigmentation0.63672482
83MP0003091_abnormal_cell_migration0.63349086
84MP0000538_abnormal_urinary_bladder0.62968393
85MP0002909_abnormal_adrenal_gland0.61189811
86MP0002229_neurodegeneration0.60727115
87MP0004085_abnormal_heartbeat0.60679841
88MP0006036_abnormal_mitochondrial_physio0.59682114
89MP0002269_muscular_atrophy0.56909266
90MP0005666_abnormal_adipose_tissue0.56686754
91MP0005332_abnormal_amino_acid0.56664598
92MP0004036_abnormal_muscle_relaxation0.56358006
93MP0005248_abnormal_Harderian_gland0.55411341
94MP0001293_anophthalmia0.52687302
95MP0005083_abnormal_biliary_tract0.51634045
96MP0004742_abnormal_vestibular_system0.51047922
97MP0000955_abnormal_spinal_cord0.50928053
98MP0000026_abnormal_inner_ear0.50693736
99MP0001672_abnormal_embryogenesis/_devel0.49941896
100MP0005380_embryogenesis_phenotype0.49941896
101MP0004859_abnormal_synaptic_plasticity0.47139226
102MP0000013_abnormal_adipose_tissue0.46860362
103MP0000534_abnormal_ureter_morphology0.45607163
104MP0004019_abnormal_vitamin_homeostasis0.45027919
105MP0009745_abnormal_behavioral_response0.44884775
106MP0010307_abnormal_tumor_latency0.44824039
107MP0005266_abnormal_metabolism0.44772765
108MP0006035_abnormal_mitochondrial_morpho0.44571770
109MP0008770_decreased_survivor_rate0.44114572
110MP0001119_abnormal_female_reproductive0.43631925
111MP0008932_abnormal_embryonic_tissue0.43047912
112MP0005171_absent_coat_pigmentation0.42876125
113MP0003942_abnormal_urinary_system0.42715067
114MP0001324_abnormal_eye_pigmentation0.42684059
115MP0003011_delayed_dark_adaptation0.42663433
116MP0002332_abnormal_exercise_endurance0.41345089
117MP0000230_abnormal_systemic_arterial0.41328085
118MP0001270_distended_abdomen0.41250110
119MP0000049_abnormal_middle_ear0.41148909
120MP0002272_abnormal_nervous_system0.40826705
121MP0001697_abnormal_embryo_size0.40349808
122MP0009278_abnormal_bone_marrow0.40252116
123MP0002080_prenatal_lethality0.40069999
124MP0008569_lethality_at_weaning0.39471811
125MP0000313_abnormal_cell_death0.38999625
126MP0003984_embryonic_growth_retardation0.38239744
127MP0003329_amyloid_beta_deposits0.38165173
128MP0009672_abnormal_birth_weight0.38097829
129MP0005167_abnormal_blood-brain_barrier0.37990534
130MP0005391_vision/eye_phenotype0.36383422
131MP0002088_abnormal_embryonic_growth/wei0.35778102
132MP0004084_abnormal_cardiac_muscle0.35279747
133MP0002084_abnormal_developmental_patter0.34189269
134MP0009115_abnormal_fat_cell0.33698410
135MP0005253_abnormal_eye_physiology0.32420890
136MP0005395_other_phenotype0.31683823
137MP0002169_no_abnormal_phenotype0.30681837
138MP0002873_normal_phenotype0.30195760
139MP0008260_abnormal_autophagy0.29640658
140MP0002085_abnormal_embryonic_tissue0.29576145
141MP0002092_abnormal_eye_morphology0.29301430
142MP0003123_paternal_imprinting0.27886026
143MP0004808_abnormal_hematopoietic_stem0.27839833
144MP0003861_abnormal_nervous_system0.27821102
145MP0003950_abnormal_plasma_membrane0.26968265
146MP0000350_abnormal_cell_proliferation0.25969867
147MP0005551_abnormal_eye_electrophysiolog0.25701771
148MP0003936_abnormal_reproductive_system0.25341755
149MP0002132_abnormal_respiratory_system0.22706634
150MP0000001_mammalian_phenotype0.22400583
151MP0002971_abnormal_brown_adipose0.22047377
152MP0001727_abnormal_embryo_implantation0.21080785
153MP0009703_decreased_birth_body0.20650405
154MP0001440_abnormal_grooming_behavior0.20449418
155MP0004145_abnormal_muscle_electrophysio0.20365632
156MP0002102_abnormal_ear_morphology0.20311973
157MP0001919_abnormal_reproductive_system0.20288823
158MP0003315_abnormal_perineum_morphology0.20231407
159MP0004197_abnormal_fetal_growth/weight/0.20229017
160MP0004043_abnormal_pH_regulation0.18623136
161MP0005319_abnormal_enzyme/_coenzyme0.17901271
162MP0002152_abnormal_brain_morphology0.16803257
163MP0003948_abnormal_gas_homeostasis0.16521240

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.17114120
2Abnormal respiratory motile cilium morphology (HP:0005938)9.17053195
3Abnormal respiratory epithelium morphology (HP:0012253)9.17053195
4Rhinitis (HP:0012384)7.60511006
5Chronic bronchitis (HP:0004469)7.33878468
6Abnormal ciliary motility (HP:0012262)7.23313427
7Severe visual impairment (HP:0001141)6.56057119
8* Infertility (HP:0000789)6.22008178
9Nasal polyposis (HP:0100582)6.16261892
10Attenuation of retinal blood vessels (HP:0007843)5.82527001
11Bony spicule pigmentary retinopathy (HP:0007737)5.74845504
12Chronic hepatic failure (HP:0100626)5.41822635
13Male infertility (HP:0003251)5.01866560
14Abnormality of the nasal mucosa (HP:0000433)4.99913020
15Hyperkalemia (HP:0002153)4.68407025
16Bronchitis (HP:0012387)4.55264333
17Bronchiectasis (HP:0002110)4.42742733
18Impulsivity (HP:0100710)4.24300621
19Abnormal spermatogenesis (HP:0008669)4.10213508
20Nephronophthisis (HP:0000090)4.07492703
21Resting tremor (HP:0002322)3.83407999
22Cone-rod dystrophy (HP:0000548)3.83309661
23Abnormal rod and cone electroretinograms (HP:0008323)3.74746741
24Abnormality of macular pigmentation (HP:0008002)3.59139572
25Hypoplastic ischia (HP:0003175)3.50142640
26Recurrent otitis media (HP:0000403)3.34132808
27Recurrent sinusitis (HP:0011108)3.26916503
28Hypoalphalipoproteinemia (HP:0003233)3.14192381
29Abnormality of the ischium (HP:0003174)3.10271843
30Generalized aminoaciduria (HP:0002909)3.08946915
31Potter facies (HP:0002009)3.07303441
32Facial shape deformation (HP:0011334)3.07303441
33Abnormality of the renal medulla (HP:0100957)3.02595247
34Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.92032320
35Truncal obesity (HP:0001956)2.91997526
36Enlarged epiphyses (HP:0010580)2.89929282
37Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.81408969
38Azoospermia (HP:0000027)2.72679383
39Recurrent bronchitis (HP:0002837)2.69521576
40Molar tooth sign on MRI (HP:0002419)2.60492177
41Abnormality of midbrain morphology (HP:0002418)2.60492177
42Tubulointerstitial nephritis (HP:0001970)2.57200173
43Gonadotropin excess (HP:0000837)2.48313409
44Progressive sensorineural hearing impairment (HP:0000408)2.46380287
45Polyuria (HP:0000103)2.45753508
46Abnormality of potassium homeostasis (HP:0011042)2.43736802
47Aplasia/Hypoplasia of the earlobes (HP:0009906)2.43239618
48Congenital sensorineural hearing impairment (HP:0008527)2.42849957
49Abnormality of the hepatic vasculature (HP:0006707)2.42363758
50Abnormal albumin level (HP:0012116)2.42076739
51Hypoalbuminemia (HP:0003073)2.42076739
52Widely patent fontanelles and sutures (HP:0004492)2.41915975
53Abnormality of the costochondral junction (HP:0000919)2.38233861
54Tubular atrophy (HP:0000092)2.37233219
55Occipital encephalocele (HP:0002085)2.34658203
56Portal hypertension (HP:0001409)2.31011337
57Hypoplasia of the thymus (HP:0000778)2.29785818
58Amelogenesis imperfecta (HP:0000705)2.26891060
59Fetal akinesia sequence (HP:0001989)2.26605132
60Abnormality of dental color (HP:0011073)2.24757257
61Spastic tetraparesis (HP:0001285)2.24583239
62Medial flaring of the eyebrow (HP:0010747)2.23202462
63Spontaneous abortion (HP:0005268)2.21021641
64Tubulointerstitial abnormality (HP:0001969)2.20928785
65Hypoplasia of the capital femoral epiphysis (HP:0003090)2.18724155
66Horizontal nystagmus (HP:0000666)2.18131515
67Menstrual irregularities (HP:0000858)2.17355896
68Postural instability (HP:0002172)2.15356687
69Glycosuria (HP:0003076)2.15328102
70Abnormality of urine glucose concentration (HP:0011016)2.15328102
71Subcapsular cataract (HP:0000523)2.14963855
72Progressive cerebellar ataxia (HP:0002073)2.14704661
73Hypolipoproteinemia (HP:0010981)2.14467454
74Hypophosphatemic rickets (HP:0004912)2.11204583
75Aplasia/Hypoplasia involving the musculature (HP:0001460)2.08438744
76Abnormality of the aortic arch (HP:0012303)2.07979392
77Insulin-resistant diabetes mellitus (HP:0000831)2.05873929
78Dynein arm defect of respiratory motile cilia (HP:0012255)12.9889607
79Absent/shortened dynein arms (HP:0200106)12.9889607
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8982321
81Neoplasm of the heart (HP:0100544)1.98029174
82Dyschromatopsia (HP:0007641)1.96146292
83Abnormality of the nasal septum (HP:0000419)1.92196554
84Hyponatremia (HP:0002902)1.90677064
85Hypoplastic heart (HP:0001961)1.89798106
86Bundle branch block (HP:0011710)1.89408351
87Bifid tongue (HP:0010297)1.89132003
88Optic nerve hypoplasia (HP:0000609)1.86232400
89Photophobia (HP:0000613)1.85456171
90Cholecystitis (HP:0001082)1.84921632
91Abnormal gallbladder physiology (HP:0012438)1.84921632
92Choroideremia (HP:0001139)1.83964215
93Facial cleft (HP:0002006)1.83793554
94Renal Fanconi syndrome (HP:0001994)1.81983613
95Respiratory distress (HP:0002098)1.80002750
96Abnormality of chloride homeostasis (HP:0011422)1.79777696
97Muscle fiber atrophy (HP:0100295)1.79592334
98Postaxial foot polydactyly (HP:0001830)1.77965383
99Renovascular hypertension (HP:0100817)1.77755121
100Tubulointerstitial fibrosis (HP:0005576)1.77468338
101Unilateral renal agenesis (HP:0000122)1.76621057
102Cerebellar dysplasia (HP:0007033)1.74533614
103Absent epiphyses (HP:0010577)1.74510999
104Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74510999
105Decreased central vision (HP:0007663)1.73992806
106Scotoma (HP:0000575)1.73770460
107Abnormality of the pubic bones (HP:0003172)1.73577245
108Congenital malformation of the right heart (HP:0011723)1.63291189
109Double outlet right ventricle (HP:0001719)1.63291189
110Abnormality of the lower motor neuron (HP:0002366)1.62145047
111Short ribs (HP:0000773)1.61975187
112Heterotopia (HP:0002282)1.61909898
113Pancreatic fibrosis (HP:0100732)1.61239012
114Stage 5 chronic kidney disease (HP:0003774)1.59139416
115Congenital hepatic fibrosis (HP:0002612)1.57468108
116Abnormality of permanent molar morphology (HP:0011071)1.55970650
117Abnormality of the dental root (HP:0006486)1.55970650
118Taurodontia (HP:0000679)1.55970650
119Bell-shaped thorax (HP:0001591)1.55969802
120Oculomotor apraxia (HP:0000657)1.55434816
121Abnormal drinking behavior (HP:0030082)1.52291172
122Polydipsia (HP:0001959)1.52291172
123Fibular hypoplasia (HP:0003038)1.51853249
124Glucose intolerance (HP:0000833)1.50790476
125Abnormality of the renal cortex (HP:0011035)1.50468066
126Abnormality of renal excretion (HP:0011036)1.49914686
127Abnormal biliary tract physiology (HP:0012439)1.49677724
128Bile duct proliferation (HP:0001408)1.49677724
129Short nail (HP:0001799)1.42670842
130Abnormality of molar (HP:0011077)1.42403285
131Abnormality of molar morphology (HP:0011070)1.42403285
132Abnormality of the dental pulp (HP:0006479)1.41865042
133Hemorrhage of the eye (HP:0011885)1.39886013
134Amyotrophic lateral sclerosis (HP:0007354)1.39024564
135Personality changes (HP:0000751)1.37671818
136Postaxial hand polydactyly (HP:0001162)1.35892415
137Broad distal phalanx of finger (HP:0009836)1.35552814
138Microglossia (HP:0000171)1.35397585
139Median cleft lip (HP:0000161)1.34778716
140Renal dysplasia (HP:0000110)1.33617893
141Cleft eyelid (HP:0000625)1.31451084
142Asymmetric septal hypertrophy (HP:0001670)1.31171407
143Cystic liver disease (HP:0006706)1.30987148
144Decreased electroretinogram (ERG) amplitude (HP:0000654)1.27949418
145Aplasia/Hypoplasia of the lens (HP:0008063)1.26312664
146Abnormality of the anterior horn cell (HP:0006802)1.26237720
147Degeneration of anterior horn cells (HP:0002398)1.26237720
148Difficulty climbing stairs (HP:0003551)1.24641110
149Easy fatigability (HP:0003388)1.24560568
150Chronic sinusitis (HP:0011109)1.24383325
151Nephropathy (HP:0000112)1.22205962
152Supernumerary spleens (HP:0009799)1.22016500
153Abnormality of dentin (HP:0010299)1.21040224
154Global brain atrophy (HP:0002283)1.20338388
155Aplasia/Hypoplasia of the tongue (HP:0010295)1.19416347
156Abnormal urine output (HP:0012590)1.19362669
157Constricted visual fields (HP:0001133)1.16365791
158Type 2 muscle fiber atrophy (HP:0003554)1.16294283
159Fatigable weakness (HP:0003473)1.14576682
160Abnormality of the neuromuscular junction (HP:0003398)1.14576682
161Short thorax (HP:0010306)1.13108137
162Vascular calcification (HP:0004934)1.12821380
163Hyperglycinemia (HP:0002154)1.12584590
164Pancreatic cysts (HP:0001737)1.12254793

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.87864743
2PDK47.87864743
3TESK16.33081008
4PDK25.12524590
5PRKD34.85073697
6ICK4.06888015
7DDR23.81951684
8BRD42.87876766
9FRK2.86539638
10PLK22.78151036
11PIK3CG2.64742804
12PNCK2.18684712
13NEK22.14675209
14PTK2B1.98549205
15MAP4K21.95847421
16INSRR1.94009338
17STK381.83071866
18WNK41.77996948
19STK391.72698728
20MST1R1.53891995
21DYRK1B1.43420274
22WEE11.36372626
23DYRK31.24494766
24BUB11.23486649
25CCNB11.23293684
26MAPK151.13848478
27PINK11.12120826
28TESK21.11964643
29MAP3K91.10389530
30MAP3K121.06879905
31PDK11.06650129
32PLK41.04958430
33TTK1.01849512
34MAP3K30.99796373
35LATS10.95903961
36NTRK30.91599345
37PRKG10.90522769
38STK30.89782659
39KSR20.88113094
40FER0.87698131
41CDK120.85690879
42MAP3K110.82074762
43BMPR1B0.81890659
44CDK70.79687239
45CAMK10.79072040
46PRKG20.78369061
47PASK0.77915855
48ADRBK20.75700424
49CHEK20.75239774
50IRAK10.74945823
51BRSK20.70950855
52PDPK10.68610076
53ACVR1B0.68327630
54OXSR10.68159705
55SIK20.67228295
56TYRO30.66951611
57TAF10.66826703
58MAP3K10.65189171
59EIF2AK10.63946864
60RIPK40.62406008
61PLK10.61437983
62WNK10.58393464
63RPS6KA20.57819726
64STK38L0.55568989
65PAK10.54678924
66CHEK10.53937941
67PRKAA20.53630252
68CAMK1D0.51569382
69AKT30.48671374
70BRSK10.45684055
71MAP3K130.45647768
72MET0.45238358
73MST40.44671889
74LATS20.44570834
75MAPK110.43383603
76ROCK10.42691299
77IKBKB0.41548738
78PRKCG0.41191172
79EEF2K0.41117228
80MAP2K60.40673521
81MAPK10.40090454
82ATR0.39554501
83TNK20.39142998
84IRAK20.38788619
85CDC70.37635243
86SGK4940.37581874
87SGK2230.37581874
88BRAF0.36273729
89SGK10.34511265
90SRPK10.32837474
91PLK30.32604870
92PAK40.32515378
93ATM0.32175924
94NEK60.32044377
95PAK20.31583261
96PRKAA10.31322456
97LMTK20.31091980
98MTOR0.30540029
99NLK0.30303742
100CAMK1G0.28869749
101RPS6KA50.28424796
102STK160.27896651
103MYLK0.27684258
104PHKG20.27604237
105PHKG10.27604237
106PRKCE0.27334744
107AURKA0.23488148
108WNK30.22883089
109EIF2AK30.22830033
110MAPK140.22585642
111MAP2K10.20447367
112PRKACB0.19826210
113CSNK2A10.18965564
114AURKB0.18886054
115CDK40.18771450
116CAMK40.18755910
117NTRK20.18207864
118MARK20.18184176
119MAP3K20.18069206
120TNIK0.17745699
121OBSCN0.17342432
122CDK20.17336036
123TLK10.17278686
124MKNK20.16965001
125RPS6KA60.16759938
126CAMKK10.16731421
127MAPKAPK30.16722812
128MUSK0.16152726
129MAP2K20.15705978
130CSNK2A20.12870056
131RPS6KB10.11951427
132CDK10.11908297
133PRKCZ0.11431471
134ARAF0.11415984
135PIM10.09982436
136CDK30.09827449
137MARK30.09786099
138RPS6KA10.09012219
139CDK150.08782799
140GSK3B0.07157979
141CDK11A0.06466787
142PIM20.05828129
143CDK180.05625080
144MAPKAPK50.05021609
145MARK10.04972866
146CSNK1D0.02691207
147CDK140.01471036
148CSNK1E0.01084167
149MAP3K50.01032471
150ZAK0.01002431
151PRKACG0.00928563
152MAP3K100.00914839
153MAPK80.00904535
154STK110.00144008
155MAP3K8-0.0232280
156DYRK2-0.0151700
157PRKCB-0.0147524
158RPS6KA4-0.0037263
159STK10-0.0006215
160CDK6-0.0004267

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.63330861
2Vitamin B6 metabolism_Homo sapiens_hsa007506.19888087
3Fatty acid biosynthesis_Homo sapiens_hsa000613.72639867
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.55985280
5Butanoate metabolism_Homo sapiens_hsa006503.20975042
6Olfactory transduction_Homo sapiens_hsa047403.19247707
7Basal transcription factors_Homo sapiens_hsa030222.82605112
8Pyruvate metabolism_Homo sapiens_hsa006202.73150599
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.59692483
10Linoleic acid metabolism_Homo sapiens_hsa005912.55047466
11RNA transport_Homo sapiens_hsa030132.38869572
12Glycerophospholipid metabolism_Homo sapiens_hsa005642.12062421
13Glucagon signaling pathway_Homo sapiens_hsa049222.07202255
14Oocyte meiosis_Homo sapiens_hsa041142.05219610
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.03856005
16Propanoate metabolism_Homo sapiens_hsa006401.99536890
17Glycerolipid metabolism_Homo sapiens_hsa005611.91238307
18Selenocompound metabolism_Homo sapiens_hsa004501.89348392
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.89274131
20Pentose phosphate pathway_Homo sapiens_hsa000301.88938550
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87983600
22Phototransduction_Homo sapiens_hsa047441.86271435
23Fanconi anemia pathway_Homo sapiens_hsa034601.85458668
24Nitrogen metabolism_Homo sapiens_hsa009101.84764923
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.83647990
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.83377562
27Purine metabolism_Homo sapiens_hsa002301.80714732
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78984312
29Phenylalanine metabolism_Homo sapiens_hsa003601.78274108
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77860301
31Fructose and mannose metabolism_Homo sapiens_hsa000511.69522888
32Pyrimidine metabolism_Homo sapiens_hsa002401.69397248
33RNA polymerase_Homo sapiens_hsa030201.60464153
34Sulfur relay system_Homo sapiens_hsa041221.55738740
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.51974684
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.47029516
37mRNA surveillance pathway_Homo sapiens_hsa030151.45497143
38Circadian entrainment_Homo sapiens_hsa047131.43946122
39Proteasome_Homo sapiens_hsa030501.43727332
40PPAR signaling pathway_Homo sapiens_hsa033201.41169220
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.40330816
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34243942
43Mineral absorption_Homo sapiens_hsa049781.33838726
44Amphetamine addiction_Homo sapiens_hsa050311.25933274
45Carbon metabolism_Homo sapiens_hsa012001.22877906
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.15305914
47Fat digestion and absorption_Homo sapiens_hsa049751.14673934
48Dorso-ventral axis formation_Homo sapiens_hsa043201.14175708
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14114362
50DNA replication_Homo sapiens_hsa030301.13441486
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12821769
52Ether lipid metabolism_Homo sapiens_hsa005651.10913705
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.09687652
54Arginine biosynthesis_Homo sapiens_hsa002201.07634827
55Huntingtons disease_Homo sapiens_hsa050161.07613102
56Glutathione metabolism_Homo sapiens_hsa004801.07317670
57Antigen processing and presentation_Homo sapiens_hsa046121.01506464
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01040945
59Fatty acid metabolism_Homo sapiens_hsa012120.98881099
60Cell cycle_Homo sapiens_hsa041100.98035660
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97816886
62Arginine and proline metabolism_Homo sapiens_hsa003300.97696721
63Cardiac muscle contraction_Homo sapiens_hsa042600.97136782
64Spliceosome_Homo sapiens_hsa030400.95841316
65Biosynthesis of amino acids_Homo sapiens_hsa012300.95404304
66Tyrosine metabolism_Homo sapiens_hsa003500.88426947
67Fatty acid degradation_Homo sapiens_hsa000710.87073232
68Tryptophan metabolism_Homo sapiens_hsa003800.83431589
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80837559
70Morphine addiction_Homo sapiens_hsa050320.80201204
71Circadian rhythm_Homo sapiens_hsa047100.79683788
72Collecting duct acid secretion_Homo sapiens_hsa049660.78248613
73Hedgehog signaling pathway_Homo sapiens_hsa043400.78208617
74Arachidonic acid metabolism_Homo sapiens_hsa005900.77167443
75Type II diabetes mellitus_Homo sapiens_hsa049300.73163911
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71896203
77Salivary secretion_Homo sapiens_hsa049700.70171699
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69060921
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67604875
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67142979
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64073785
82RNA degradation_Homo sapiens_hsa030180.63691753
83Retinol metabolism_Homo sapiens_hsa008300.63516788
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62760107
85Systemic lupus erythematosus_Homo sapiens_hsa053220.62184225
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61548427
87Vitamin digestion and absorption_Homo sapiens_hsa049770.61276159
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.58564301
89Epstein-Barr virus infection_Homo sapiens_hsa051690.57632578
90Renin-angiotensin system_Homo sapiens_hsa046140.56301492
91Homologous recombination_Homo sapiens_hsa034400.56093110
92Base excision repair_Homo sapiens_hsa034100.53432419
93Metabolic pathways_Homo sapiens_hsa011000.52866556
94Nucleotide excision repair_Homo sapiens_hsa034200.51526236
95Nicotine addiction_Homo sapiens_hsa050330.49986625
96Lysine degradation_Homo sapiens_hsa003100.49294136
97Renin secretion_Homo sapiens_hsa049240.48626767
98cAMP signaling pathway_Homo sapiens_hsa040240.47605400
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46748491
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.44779666
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44609306
102Chemical carcinogenesis_Homo sapiens_hsa052040.44392377
103Type I diabetes mellitus_Homo sapiens_hsa049400.42678077
104beta-Alanine metabolism_Homo sapiens_hsa004100.42371621
105Estrogen signaling pathway_Homo sapiens_hsa049150.41713633
106Peroxisome_Homo sapiens_hsa041460.41108828
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40612011
108Thyroid hormone synthesis_Homo sapiens_hsa049180.39324155
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39318492
110Insulin secretion_Homo sapiens_hsa049110.39010565
111Legionellosis_Homo sapiens_hsa051340.38911125
112AMPK signaling pathway_Homo sapiens_hsa041520.38504406
113Inositol phosphate metabolism_Homo sapiens_hsa005620.38322860
114Long-term potentiation_Homo sapiens_hsa047200.37382360
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.36930822
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.36613101
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.35418834
118Complement and coagulation cascades_Homo sapiens_hsa046100.33356456
119Insulin resistance_Homo sapiens_hsa049310.33034927
120Endocytosis_Homo sapiens_hsa041440.32175558
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32110752
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31448099
123Protein digestion and absorption_Homo sapiens_hsa049740.30693782
124ABC transporters_Homo sapiens_hsa020100.30439081
125Tight junction_Homo sapiens_hsa045300.28829849
126GABAergic synapse_Homo sapiens_hsa047270.27865273
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27713458
128Bile secretion_Homo sapiens_hsa049760.27084193
129One carbon pool by folate_Homo sapiens_hsa006700.26679077
130Calcium signaling pathway_Homo sapiens_hsa040200.25742165
131Autoimmune thyroid disease_Homo sapiens_hsa053200.25676928
132Regulation of autophagy_Homo sapiens_hsa041400.25511294
133Synaptic vesicle cycle_Homo sapiens_hsa047210.25196254
134Glutamatergic synapse_Homo sapiens_hsa047240.24778670
135Pancreatic secretion_Homo sapiens_hsa049720.24617015
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23473542
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.23449356
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23081706
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22236895
140Influenza A_Homo sapiens_hsa051640.22151372
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21260747
142Viral carcinogenesis_Homo sapiens_hsa052030.19783209
143Alcoholism_Homo sapiens_hsa050340.19775839
144Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19258923
145p53 signaling pathway_Homo sapiens_hsa041150.19132016
146Mismatch repair_Homo sapiens_hsa034300.18547033
147Taste transduction_Homo sapiens_hsa047420.18022993

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