KLHDC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2, a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found to be expressed specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasma and meiotic chromatin, suggesting that this gene may be involved in meiotic recombination. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-arginine omega-N-methylation (GO:0035247)4.24142814
2positive regulation of synapse maturation (GO:0090129)3.97740071
3negative regulation of microtubule polymerization (GO:0031115)3.97728063
4synaptic vesicle maturation (GO:0016188)3.96622206
5piRNA metabolic process (GO:0034587)3.90285693
6creatine metabolic process (GO:0006600)3.81273006
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.80980849
8synaptic vesicle docking involved in exocytosis (GO:0016081)3.73246819
9peptidyl-arginine methylation (GO:0018216)3.72455391
10peptidyl-arginine N-methylation (GO:0035246)3.72455391
11NADH metabolic process (GO:0006734)3.71812928
12protein complex localization (GO:0031503)3.59622288
13response to pheromone (GO:0019236)3.59495983
14histone arginine methylation (GO:0034969)3.55078438
15cellular potassium ion homeostasis (GO:0030007)3.48729467
16neuronal ion channel clustering (GO:0045161)3.44506747
17glutamate secretion (GO:0014047)3.43283313
18protein insertion into membrane (GO:0051205)3.39596104
19regulation of chromatin binding (GO:0035561)3.38506038
20establishment of mitochondrion localization (GO:0051654)3.38161666
21binding of sperm to zona pellucida (GO:0007339)3.37499210
22protein maturation by protein folding (GO:0022417)3.33705098
23sodium ion export (GO:0071436)3.32676130
24regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.31413848
25protein retention in ER lumen (GO:0006621)3.28752373
26synaptic vesicle exocytosis (GO:0016079)3.27578783
27negative regulation of organelle assembly (GO:1902116)3.27141779
28regulation of short-term neuronal synaptic plasticity (GO:0048172)3.26754021
29glycolytic process (GO:0006096)3.26731991
30cerebellar granule cell differentiation (GO:0021707)3.26476986
31sperm motility (GO:0030317)3.24600813
32retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.24287130
33sperm-egg recognition (GO:0035036)3.23255340
34nucleosome disassembly (GO:0006337)3.22934396
35protein-DNA complex disassembly (GO:0032986)3.22934396
36Golgi transport vesicle coating (GO:0048200)3.22150353
37COPI coating of Golgi vesicle (GO:0048205)3.22150353
38synaptonemal complex assembly (GO:0007130)3.20311763
39hexose biosynthetic process (GO:0019319)3.15857155
40pre-miRNA processing (GO:0031054)3.14959846
41positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.13781144
42DNA unwinding involved in DNA replication (GO:0006268)3.13507910
43synaptonemal complex organization (GO:0070193)3.12957965
44DNA deamination (GO:0045006)3.12278390
45regulation of early endosome to late endosome transport (GO:2000641)3.09400614
46intracellular estrogen receptor signaling pathway (GO:0030520)3.07538149
47monosaccharide biosynthetic process (GO:0046364)3.07182566
48deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.06211262
49amino acid import (GO:0043090)3.06158795
50locomotory exploration behavior (GO:0035641)3.04927917
51regulation of mammary gland epithelial cell proliferation (GO:0033599)3.03627589
52actin-myosin filament sliding (GO:0033275)3.02951213
53muscle filament sliding (GO:0030049)3.02951213
54negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02498776
55regulation of translational termination (GO:0006449)3.02233780
56cytoskeletal anchoring at plasma membrane (GO:0007016)3.01197663
57male meiosis (GO:0007140)3.00044146
58establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.99062175
59mitochondrion transport along microtubule (GO:0047497)2.99062175
60negative regulation of cell size (GO:0045792)2.97855543
61oxaloacetate metabolic process (GO:0006107)2.96156285
62establishment of integrated proviral latency (GO:0075713)2.95062081
63negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.94900780
64histone H2A acetylation (GO:0043968)2.94829938
65peptidyl-lysine dimethylation (GO:0018027)2.93602166
66neuromuscular process controlling balance (GO:0050885)2.92759375
67maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.91536833
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91026558
69regulation of translational fidelity (GO:0006450)2.89925019
70cell communication by electrical coupling (GO:0010644)2.88884556
71proline metabolic process (GO:0006560)2.88445820
72neuronal action potential propagation (GO:0019227)2.85639228
73regulation of NFAT protein import into nucleus (GO:0051532)2.84894455
74layer formation in cerebral cortex (GO:0021819)2.84543343
75positive regulation of dendritic spine development (GO:0060999)2.83992783
76positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.81294933
77positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.81014109
78regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.80187253
79microtubule severing (GO:0051013)2.79632479
80adenine nucleotide transport (GO:0051503)2.79108538
81sarcoplasmic reticulum calcium ion transport (GO:0070296)2.78821501
82cell-cell recognition (GO:0009988)2.78472127
83regulation of synapse structural plasticity (GO:0051823)2.78287013
84L-amino acid import (GO:0043092)2.76981766
85mitotic G1 DNA damage checkpoint (GO:0031571)2.76771458
86regulation of synaptic vesicle exocytosis (GO:2000300)2.73546438
87tricarboxylic acid cycle (GO:0006099)2.73230150
88regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.72578570
89fusion of sperm to egg plasma membrane (GO:0007342)2.71305199
90postreplication repair (GO:0006301)2.70915211
91protein polyglutamylation (GO:0018095)2.70808360
92regulation of synaptic plasticity (GO:0048167)2.70417966
93vocalization behavior (GO:0071625)2.70178462
94cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.69746106
95heterochromatin organization (GO:0070828)2.69393628
96regulation of synaptic vesicle transport (GO:1902803)2.69248767
97DNA strand elongation involved in DNA replication (GO:0006271)2.68929543
98cerebellar Purkinje cell layer development (GO:0021680)2.67984968
99cardiac muscle contraction (GO:0060048)2.67877888
100gene silencing by RNA (GO:0031047)2.67387598
101proline biosynthetic process (GO:0006561)2.67148804
102neurotransmitter transport (GO:0006836)2.66964265
103translesion synthesis (GO:0019985)2.65796019
104regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.65546158
105tricarboxylic acid metabolic process (GO:0072350)2.63581621
106pyrimidine nucleotide catabolic process (GO:0006244)2.62421090
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.62376267
108gene silencing (GO:0016458)2.61384757
109regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.60678200
110motile cilium assembly (GO:0044458)2.59437852
111pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.57780588
112regulation of ARF protein signal transduction (GO:0032012)2.54761824
113dendritic spine organization (GO:0097061)2.54639101
114nucleoside diphosphate biosynthetic process (GO:0009133)2.53726525
115establishment of viral latency (GO:0019043)2.53490005
116peptidyl-arginine modification (GO:0018195)2.52848231
117striated muscle contraction (GO:0006941)2.52822649
118mitochondrial fusion (GO:0008053)2.51160332
119regulation of cilium movement (GO:0003352)2.51091328
120activation of protein kinase A activity (GO:0034199)2.50863026
121neurotransmitter secretion (GO:0007269)2.50572460
122DNA replication-dependent nucleosome assembly (GO:0006335)2.50564400
123DNA replication-dependent nucleosome organization (GO:0034723)2.50564400
124substantia nigra development (GO:0021762)2.50196845
1252-oxoglutarate metabolic process (GO:0006103)2.49949739
126acrosome reaction (GO:0007340)2.49392651
127oxidative phosphorylation (GO:0006119)2.49118839
128regulation of neurotransmitter levels (GO:0001505)2.48997767
129regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.48811319
130ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.48805768
131DNA strand elongation (GO:0022616)2.47860327
132postsynaptic membrane organization (GO:0001941)2.46557455
133potassium ion homeostasis (GO:0055075)2.46502276
134synaptic vesicle endocytosis (GO:0048488)2.46330408
135regulation of voltage-gated calcium channel activity (GO:1901385)2.46134966
136spermatid development (GO:0007286)2.44428961
137DNA methylation involved in gamete generation (GO:0043046)2.43810991
138folic acid-containing compound biosynthetic process (GO:0009396)2.43008671
139regulation of neuronal synaptic plasticity (GO:0048168)2.42614378
140cell migration in hindbrain (GO:0021535)2.42024467
141chromatin silencing (GO:0006342)2.41625104
142negative regulation of RNA splicing (GO:0033119)2.41400031
143regulation of synapse maturation (GO:0090128)2.40382866
144regulation of glutamate receptor signaling pathway (GO:1900449)2.39828691
145plasma membrane fusion (GO:0045026)2.39515752
146gluconeogenesis (GO:0006094)2.39485057
147exploration behavior (GO:0035640)2.39085496
148protein localization to synapse (GO:0035418)2.36653637
149negative regulation of gene expression, epigenetic (GO:0045814)2.33602837
150calcium ion-dependent exocytosis (GO:0017156)2.31661547
151cilium or flagellum-dependent cell motility (GO:0001539)2.31624485
152meiotic nuclear division (GO:0007126)2.31383433
153spliceosomal tri-snRNP complex assembly (GO:0000244)2.30750119
154mitotic nuclear envelope disassembly (GO:0007077)2.29479975
155mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.29352321
156regulation of long-term neuronal synaptic plasticity (GO:0048169)2.27731798
157DNA replication initiation (GO:0006270)2.26883386
158nuclear envelope disassembly (GO:0051081)2.26514530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.36834190
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.17080999
3EZH2_22144423_ChIP-Seq_EOC_Human2.72308434
4E2F7_22180533_ChIP-Seq_HELA_Human2.50465785
5MYC_22102868_ChIP-Seq_BL_Human2.46275898
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.44355333
7* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.19297137
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.13171015
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11715171
10LXR_22292898_ChIP-Seq_THP-1_Human2.06764728
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.05649411
12SRY_22984422_ChIP-ChIP_TESTIS_Rat1.99425874
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97293014
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93275457
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.93032901
16ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.91684562
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90387522
18* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.88244657
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86934272
20MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84745595
21FOXM1_23109430_ChIP-Seq_U2OS_Human1.84287687
22P68_20966046_ChIP-Seq_HELA_Human1.78429061
23ELF1_20517297_ChIP-Seq_JURKAT_Human1.78226825
24THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77513545
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76859190
26XRN2_22483619_ChIP-Seq_HELA_Human1.74829626
27SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.70347295
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69293522
29YY1_22570637_ChIP-Seq_MALME-3M_Human1.67880721
30TET1_21451524_ChIP-Seq_MESCs_Mouse1.66677301
31* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.65176470
32KDM2B_26808549_Chip-Seq_DND41_Human1.59767719
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.58289999
34CIITA_25753668_ChIP-Seq_RAJI_Human1.58057988
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55351244
36* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.54908719
37EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.54427309
38VDR_21846776_ChIP-Seq_THP-1_Human1.53576983
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50553166
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49088074
41ZNF263_19887448_ChIP-Seq_K562_Human1.47287635
42BCL6_27268052_Chip-Seq_Bcells_Human1.45511541
43PHF8_20622854_ChIP-Seq_HELA_Human1.44099867
44SMC4_20622854_ChIP-Seq_HELA_Human1.42058582
45FOXP1_21924763_ChIP-Seq_HESCs_Human1.41695023
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41446418
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.40720931
48REST_18959480_ChIP-ChIP_MESCs_Mouse1.39680842
49* ETS1_20019798_ChIP-Seq_JURKAT_Human1.37525149
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36091313
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.34847413
52GABP_19822575_ChIP-Seq_HepG2_Human1.34122167
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33989212
54* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32997392
55CTCF_18555785_ChIP-Seq_MESCs_Mouse1.32887855
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32656288
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32446076
58SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.32184411
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31703694
60CTCF_27219007_Chip-Seq_Bcells_Human1.31150452
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.31044741
62BCOR_27268052_Chip-Seq_Bcells_Human1.30860104
63E2F1_20622854_ChIP-Seq_HELA_Human1.30583875
64TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.30248873
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30194875
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30126344
67SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.29073063
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28595910
69TCF7_22412390_ChIP-Seq_EML_Mouse1.27899071
70* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26641854
71SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26069233
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25788385
73SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25753677
74* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25545208
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25491487
76SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24964533
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24731776
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23214711
79KDM2B_26808549_Chip-Seq_K562_Human1.23039358
80REST_21632747_ChIP-Seq_MESCs_Mouse1.22342407
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.19896912
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18780384
83OCT4_18692474_ChIP-Seq_MEFs_Mouse1.18237310
84CTCF_21964334_ChIP-Seq_BJAB-B_Human1.16286875
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16052794
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15449324
87UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15408772
88* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14768297
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13319877
90EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12430282
91ELK3_25401928_ChIP-Seq_HUVEC_Human1.11985081
92CREB1_26743006_Chip-Seq_LNCaP_Human1.11700760
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11533713
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10393714
95NANOG_21062744_ChIP-ChIP_HESCs_Human1.10345382
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09642068
97FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09591901
98CTCF_20526341_ChIP-Seq_ESCs_Human1.09050345
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08161155
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07040108
101RACK7_27058665_Chip-Seq_MCF-7_Human1.06073376
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05944240
103SA1_27219007_Chip-Seq_Bcells_Human1.05674073
104CLOCK_20551151_ChIP-Seq_293T_Human1.05230189
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04850807
106ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.04849176
107RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04455207
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04186459
109TET1_21490601_ChIP-Seq_MESCs_Mouse1.02930402
110CTCF_21964334_Chip-Seq_Bcells_Human1.02789355
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02684989
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02675010
113OCT4_19829295_ChIP-Seq_ESCs_Human1.02532287
114CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02450941
115TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02059497
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01919386
117ETS1_21867929_ChIP-Seq_TH2_Mouse1.01060153
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00968733
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00574315
120TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00181580
121FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99913616
122ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99621007
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98729215
124TP53_22127205_ChIP-Seq_IMR90_Human0.98168296
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97826450
126MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97617346
127SOX2_21211035_ChIP-Seq_LN229_Human0.95747382

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.01068035
2MP0005410_abnormal_fertilization3.29293761
3MP0002653_abnormal_ependyma_morphology3.27998445
4MP0008877_abnormal_DNA_methylation3.13526635
5MP0003646_muscle_fatigue3.11990265
6MP0000751_myopathy2.46016360
7MP0005451_abnormal_body_composition2.43081702
8MP0003635_abnormal_synaptic_transmissio2.41616305
9MP0004233_abnormal_muscle_weight2.39342893
10MP0003123_paternal_imprinting2.27887524
11MP0003111_abnormal_nucleus_morphology1.99694886
12MP0002822_catalepsy1.98526889
13MP0003283_abnormal_digestive_organ1.97664396
14MP0002063_abnormal_learning/memory/cond1.96387862
15MP0003698_abnormal_male_reproductive1.92296129
16MP0008260_abnormal_autophagy1.83288744
17MP0001929_abnormal_gametogenesis1.80088831
18MP0000750_abnormal_muscle_regeneration1.70477952
19MP0004270_analgesia1.70474184
20MP0004145_abnormal_muscle_electrophysio1.69108639
21MP0003329_amyloid_beta_deposits1.65969662
22MP0002269_muscular_atrophy1.63475365
23MP0008961_abnormal_basal_metabolism1.63236454
24MP0001730_embryonic_growth_arrest1.59894449
25MP0010094_abnormal_chromosome_stability1.58167544
26MP0003119_abnormal_digestive_system1.54272135
27MP0004147_increased_porphyrin_level1.53403918
28MP0004811_abnormal_neuron_physiology1.52771142
29MP0001346_abnormal_lacrimal_gland1.48721865
30MP0010030_abnormal_orbit_morphology1.48202702
31MP0002234_abnormal_pharynx_morphology1.45517850
32MP0004858_abnormal_nervous_system1.44716425
33MP0009278_abnormal_bone_marrow1.44315046
34MP0004133_heterotaxia1.44187627
35MP0004957_abnormal_blastocyst_morpholog1.42435751
36MP0002089_abnormal_postnatal_growth/wei1.41084966
37MP0002210_abnormal_sex_determination1.40194338
38MP0003693_abnormal_embryo_hatching1.38007758
39MP0002837_dystrophic_cardiac_calcinosis1.35551330
40MP0002064_seizures1.34920840
41MP0005423_abnormal_somatic_nervous1.34818497
42MP0006276_abnormal_autonomic_nervous1.34562917
43MP0002161_abnormal_fertility/fecundity1.33718189
44MP0003122_maternal_imprinting1.32671730
45MP0001486_abnormal_startle_reflex1.32431224
46MP0001968_abnormal_touch/_nociception1.30027770
47MP0003077_abnormal_cell_cycle1.29797970
48MP0003880_abnormal_central_pattern1.28513513
49MP0009745_abnormal_behavioral_response1.27792598
50MP0003656_abnormal_erythrocyte_physiolo1.26959195
51MP0009046_muscle_twitch1.26364577
52MP0005623_abnormal_meninges_morphology1.26175132
53MP0001145_abnormal_male_reproductive1.25822217
54MP0005330_cardiomyopathy1.25307195
55MP0002249_abnormal_larynx_morphology1.24893133
56MP0002572_abnormal_emotion/affect_behav1.24815120
57MP0003879_abnormal_hair_cell1.22635409
58MP0002736_abnormal_nociception_after1.22616041
59MP0005058_abnormal_lysosome_morphology1.22240742
60MP0001697_abnormal_embryo_size1.20271074
61MP0003705_abnormal_hypodermis_morpholog1.20108478
62MP0005369_muscle_phenotype1.20092355
63MP0000955_abnormal_spinal_cord1.19824153
64MP0001849_ear_inflammation1.18700155
65MP0002909_abnormal_adrenal_gland1.18014718
66MP0006036_abnormal_mitochondrial_physio1.14725199
67MP0008569_lethality_at_weaning1.13295399
68MP0002084_abnormal_developmental_patter1.12317618
69MP0004130_abnormal_muscle_cell1.11275261
70MP0000653_abnormal_sex_gland1.11256001
71MP0004215_abnormal_myocardial_fiber1.10822536
72MP0000358_abnormal_cell_content/1.10740168
73MP0003861_abnormal_nervous_system1.08848958
74MP0006035_abnormal_mitochondrial_morpho1.08535317
75MP0010630_abnormal_cardiac_muscle1.06453248
76MP0002272_abnormal_nervous_system1.06417633
77MP0004084_abnormal_cardiac_muscle1.06359015
78MP0000749_muscle_degeneration1.06046807
79MP0001529_abnormal_vocalization1.04876095
80MP0004087_abnormal_muscle_fiber1.04749361
81MP0002080_prenatal_lethality1.04681741
82MP0002152_abnormal_brain_morphology1.03717409
83MP0004036_abnormal_muscle_relaxation1.03540097
84MP0002184_abnormal_innervation1.02989916
85MP0002085_abnormal_embryonic_tissue1.02796737
86MP0002106_abnormal_muscle_physiology1.01493010
87MP0008872_abnormal_physiological_respon0.99773676
88MP0000350_abnormal_cell_proliferation0.99494993
89MP0004185_abnormal_adipocyte_glucose0.99432525
90MP0000747_muscle_weakness0.97578566
91MP0003121_genomic_imprinting0.97546806
92MP0002733_abnormal_thermal_nociception0.96507473
93MP0003634_abnormal_glial_cell0.96283383
94MP0002160_abnormal_reproductive_system0.95638040
95MP0003137_abnormal_impulse_conducting0.94438566
96MP0005377_hearing/vestibular/ear_phenot0.93788945
97MP0003878_abnormal_ear_physiology0.93788945
98MP0002734_abnormal_mechanical_nocicepti0.93419829
99MP0000759_abnormal_skeletal_muscle0.92814362
100MP0008874_decreased_physiological_sensi0.92365554
101MP0001970_abnormal_pain_threshold0.91227851
102MP0002067_abnormal_sensory_capabilities0.89562745
103MP0005666_abnormal_adipose_tissue0.87967873
104MP0001672_abnormal_embryogenesis/_devel0.87744129
105MP0005380_embryogenesis_phenotype0.87744129
106MP0003690_abnormal_glial_cell0.87448264
107MP0001984_abnormal_olfaction0.86572323
108MP0005394_taste/olfaction_phenotype0.85993933
109MP0005499_abnormal_olfactory_system0.85993933
110MP0009672_abnormal_birth_weight0.85490287
111MP0000778_abnormal_nervous_system0.84607391
112MP0002102_abnormal_ear_morphology0.83935625
113MP0000534_abnormal_ureter_morphology0.83812848
114MP0005670_abnormal_white_adipose0.83227406
115MP0003221_abnormal_cardiomyocyte_apopto0.81743876
116MP0003115_abnormal_respiratory_system0.81395019
117MP0000537_abnormal_urethra_morphology0.81265112
118MP0002735_abnormal_chemical_nociception0.80742147
119MP0000604_amyloidosis0.80544200
120MP0002557_abnormal_social/conspecific_i0.80274544
121MP0000920_abnormal_myelination0.80182762
122MP0000681_abnormal_thyroid_gland0.80003478
123MP0000678_abnormal_parathyroid_gland0.79830294
124MP0002066_abnormal_motor_capabilities/c0.79641556
125MP0005620_abnormal_muscle_contractility0.79300119
126MP0000003_abnormal_adipose_tissue0.79204517
127MP0001502_abnormal_circadian_rhythm0.79158807
128MP0003984_embryonic_growth_retardation0.78752025
129MP0001299_abnormal_eye_distance/0.78698078
130MP0008932_abnormal_embryonic_tissue0.78695470
131MP0002882_abnormal_neuron_morphology0.78008776
132MP0008770_decreased_survivor_rate0.77582896
133MP0002088_abnormal_embryonic_growth/wei0.77502211
134MP0001905_abnormal_dopamine_level0.77091155
135MP0003075_altered_response_to0.77027355
136MP0002972_abnormal_cardiac_muscle0.76581950
137MP0003385_abnormal_body_wall0.74711617
138MP0000733_abnormal_muscle_development0.74229118
139MP0003631_nervous_system_phenotype0.68970615
140MP0005646_abnormal_pituitary_gland0.68919334
141MP0005375_adipose_tissue_phenotype0.67041658

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)4.82478955
2Myokymia (HP:0002411)4.27661586
3Nemaline bodies (HP:0003798)4.15388029
4Muscle fiber inclusion bodies (HP:0100299)4.12199528
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.99075217
6Myopathic facies (HP:0002058)3.94097968
7Insomnia (HP:0100785)3.65342208
8Muscle stiffness (HP:0003552)3.34926693
9Abnormal gallbladder physiology (HP:0012438)3.33725453
10Cholecystitis (HP:0001082)3.33725453
11Hyperacusis (HP:0010780)3.33126161
12Visual hallucinations (HP:0002367)3.25812931
13Amyotrophic lateral sclerosis (HP:0007354)3.04408229
14Type 1 muscle fiber predominance (HP:0003803)2.93855174
15Exercise-induced myalgia (HP:0003738)2.92921010
16Annular pancreas (HP:0001734)2.87842469
17Abnormality of glycolysis (HP:0004366)2.85258218
18Male infertility (HP:0003251)2.83191763
19Renal duplication (HP:0000075)2.80740089
20Ependymoma (HP:0002888)2.76643399
21Elfin facies (HP:0004428)2.74197075
22Ankle clonus (HP:0011448)2.73014966
23EMG: myopathic abnormalities (HP:0003458)2.71387934
24Calcaneovalgus deformity (HP:0001848)2.71333795
25Pointed chin (HP:0000307)2.70195504
26Distal lower limb muscle weakness (HP:0009053)2.67448644
27Infertility (HP:0000789)2.62965431
28Lower limb amyotrophy (HP:0007210)2.61537656
29Poor eye contact (HP:0000817)2.59191071
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.58010596
31Absent/shortened dynein arms (HP:0200106)2.58010596
32Myoglobinuria (HP:0002913)2.57703418
33Increased connective tissue (HP:0009025)2.55610522
34Increased serum pyruvate (HP:0003542)2.50828851
35Distal lower limb amyotrophy (HP:0008944)2.50102523
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.49562263
37Distal arthrogryposis (HP:0005684)2.46362475
38Tetraplegia (HP:0002445)2.42101689
39Shoulder girdle muscle weakness (HP:0003547)2.39910251
40Abnormality of skeletal muscle fiber size (HP:0012084)2.38372822
41Neoplasm of the heart (HP:0100544)2.38193217
42Renovascular hypertension (HP:0100817)2.37419141
43Foot dorsiflexor weakness (HP:0009027)2.35634466
44Sudden death (HP:0001699)2.32867550
45Peripheral hypomyelination (HP:0007182)2.30648686
46Atrophy/Degeneration involving motor neurons (HP:0007373)2.29947178
47Abnormal social behavior (HP:0012433)2.29921750
48Impaired social interactions (HP:0000735)2.29921750
49Deep palmar crease (HP:0006191)2.28620287
50Round ear (HP:0100830)2.28596424
51Deformed tarsal bones (HP:0008119)2.27316777
52Chronic bronchitis (HP:0004469)2.26663869
53Rimmed vacuoles (HP:0003805)2.25769547
54Spastic gait (HP:0002064)2.25381747
55Abnormality of the foot musculature (HP:0001436)2.25109316
56Reticulocytosis (HP:0001923)2.25010940
57Hand muscle atrophy (HP:0009130)2.24870000
58Hyporeflexia of lower limbs (HP:0002600)2.23153728
59Ventricular fibrillation (HP:0001663)2.22667270
60Megalocornea (HP:0000485)2.21504761
61Muscle fiber splitting (HP:0003555)2.21169614
62Limb-girdle muscle atrophy (HP:0003797)2.19561139
63Truncus arteriosus (HP:0001660)2.19211214
64Exercise-induced muscle cramps (HP:0003710)2.18727264
65Neuronal loss in central nervous system (HP:0002529)2.18473202
66Neck muscle weakness (HP:0000467)2.18325018
67Achilles tendon contracture (HP:0001771)2.15403229
68Cerebral inclusion bodies (HP:0100314)2.15214368
69Dysmetric saccades (HP:0000641)2.14998608
70Urinary urgency (HP:0000012)2.13945644
71Ragged-red muscle fibers (HP:0003200)2.13580724
72Overriding aorta (HP:0002623)2.13399257
73Upper limb amyotrophy (HP:0009129)2.11795063
74Distal upper limb amyotrophy (HP:0007149)2.11795063
75Depression (HP:0000716)2.11492892
76Abnormality of the calcaneus (HP:0008364)2.11292108
77Bowel incontinence (HP:0002607)2.11190745
78Increased variability in muscle fiber diameter (HP:0003557)2.10441774
79Neurofibrillary tangles (HP:0002185)2.09962407
80Angiofibromas (HP:0010615)2.09255247
81Adenoma sebaceum (HP:0009720)2.09255247
82Unsteady gait (HP:0002317)2.08966545
83Focal seizures (HP:0007359)2.08816101
84Broad palm (HP:0001169)2.08435500
85Difficulty climbing stairs (HP:0003551)2.07663303
86Epileptic encephalopathy (HP:0200134)2.07007789
87Focal motor seizures (HP:0011153)2.06195768
88Astrocytoma (HP:0009592)2.05853073
89Abnormality of the astrocytes (HP:0100707)2.05853073
90Abnormal gallbladder morphology (HP:0012437)2.03733219
91Asymmetric septal hypertrophy (HP:0001670)2.02795089
92Cerebral hypomyelination (HP:0006808)2.02659075
93Abnormality of the Achilles tendon (HP:0005109)2.02465380
94Abnormal large intestine physiology (HP:0012700)2.02448157
95Impaired vibration sensation in the lower limbs (HP:0002166)1.99823900
96Hyperthyroidism (HP:0000836)1.99805985
97EMG: neuropathic changes (HP:0003445)1.99444935
98Clonus (HP:0002169)1.99398287
99Impaired smooth pursuit (HP:0007772)1.98948849
100Abnormality of the motor neurons (HP:0002450)1.98630897
101Abnormal neuron morphology (HP:0012757)1.98630897
102Bundle branch block (HP:0011710)1.98469258
103Delusions (HP:0000746)1.98465125
104Abnormality of ocular smooth pursuit (HP:0000617)1.96310243
105Pelvic girdle muscle weakness (HP:0003749)1.95300527
106Rhabdomyolysis (HP:0003201)1.95140880
107Focal dystonia (HP:0004373)1.92256879
108Oral leukoplakia (HP:0002745)1.91673005
109Action tremor (HP:0002345)1.91636508
110Centrally nucleated skeletal muscle fibers (HP:0003687)1.90693294
111Abnormality of the aortic arch (HP:0012303)1.89099629
112Myotonia (HP:0002486)1.88472996
113Torticollis (HP:0000473)1.87698686
114Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86953270
115Sacral dimple (HP:0000960)1.84670375
116Cholelithiasis (HP:0001081)1.83894493
117Flat cornea (HP:0007720)1.83296438
118Generalized tonic-clonic seizures (HP:0002069)1.81538955
119Craniofacial dystonia (HP:0012179)1.80897033
120Nasal polyposis (HP:0100582)1.79707494
121Hammertoe (HP:0001765)1.78844820
122Ulnar deviation of the wrist (HP:0003049)1.78838524
123Obstructive sleep apnea (HP:0002870)1.78427260
124Abnormal respiratory motile cilium morphology (HP:0005938)1.78006959
125Abnormal respiratory epithelium morphology (HP:0012253)1.78006959
126Abnormality of reticulocytes (HP:0004312)1.77722107
127Dysmetria (HP:0001310)1.77625180
128Neoplasm of the peripheral nervous system (HP:0100007)1.77158633
129Rigidity (HP:0002063)1.75292471
130Generalized hyperpigmentation (HP:0007440)1.73668653
131Abnormality of the musculature of the pelvis (HP:0001469)1.73651321
132Abnormality of the hip-girdle musculature (HP:0001445)1.73651321
133Rapidly progressive (HP:0003678)1.73465659
134Abnormality of the anterior horn cell (HP:0006802)1.72895491
135Degeneration of anterior horn cells (HP:0002398)1.72895491
136Athetosis (HP:0002305)1.71628885
137Apathy (HP:0000741)1.71550402
138Adducted thumb (HP:0001181)1.70129415
139Supranuclear gaze palsy (HP:0000605)1.69978179
140Abnormality of the heme biosynthetic pathway (HP:0010472)1.69958907
141Abnormal atrioventricular conduction (HP:0005150)1.69716876
142Progressive muscle weakness (HP:0003323)1.68815272
143Abnormality of the left ventricular outflow tract (HP:0011103)1.68466380
144Subaortic stenosis (HP:0001682)1.68466380
145Hypoplasia of the brainstem (HP:0002365)1.67734844
146Aplasia/Hypoplasia of the brainstem (HP:0007362)1.67734844
147Emotional lability (HP:0000712)1.67391637
148Diplopia (HP:0000651)1.66999313
149Abnormality of binocular vision (HP:0011514)1.66999313
150Increased nuchal translucency (HP:0010880)1.66843975
151Microvesicular hepatic steatosis (HP:0001414)1.66511191
152Carpal bone hypoplasia (HP:0001498)1.65518634
153Status epilepticus (HP:0002133)1.64727694
154Postural instability (HP:0002172)1.64601831
155Hemiparesis (HP:0001269)1.63938629
156Anosmia (HP:0000458)1.62979873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD33.70005115
2EEF2K3.08189331
3ICK2.83036020
4MAP3K92.83002974
5KSR22.69412690
6TESK12.54291162
7NEK12.41795612
8PDK32.31074400
9PDK42.31074400
10TRIB32.23910988
11PAK61.96740411
12OBSCN1.95568807
13PKN21.89769719
14MINK11.78527766
15MAP3K101.77566045
16NME21.75918729
17DAPK11.70614778
18TAOK11.67804218
19DAPK21.66848143
20TESK21.65051804
21TTN1.64402988
22MAP3K111.63725452
23BUB11.62903607
24CDK191.62119688
25TYRO31.61506094
26KSR11.59998597
27LATS21.59509786
28SMG11.57616688
29MAP3K41.56715446
30SCYL21.55079128
31NEK21.50408354
32MARK11.42502035
33NTRK31.40775987
34MAPKAPK31.35760959
35CDC71.35055130
36EPHA41.28665559
37UHMK11.28276679
38MAP2K41.24728489
39VRK21.21842150
40BRAF1.20362115
41STK381.15739435
42NTRK21.15675226
43PHKG21.15245508
44PHKG11.15245508
45CCNB11.09880423
46MAPK121.08840866
47DYRK31.08061301
48MAP3K61.00342071
49CDK180.99283584
50CAMKK10.96087705
51CDK150.96074165
52PINK10.95727482
53CDK11A0.93914403
54TAOK20.87009347
55RIPK10.86667705
56PIM20.85963535
57RAF10.85100718
58CDK140.83430449
59CAMK2G0.82496353
60PAK40.81224726
61PTK2B0.79142288
62BRSK10.78160335
63SRPK10.78099599
64CDK120.77021740
65GRK50.75996869
66ERN10.73825449
67TTK0.72903439
68SIK30.72769619
69EIF2AK10.71588481
70CAMK2B0.70858796
71PRPF4B0.69944242
72WEE10.69454888
73MOS0.69232131
74KDR0.68684249
75NME10.68155199
76ALK0.67514208
77AURKA0.67185522
78LIMK10.67003405
79DYRK1B0.66350596
80MAP3K130.66159414
81DAPK30.65249371
82SIK20.65022101
83ARAF0.63059214
84CDK50.62690520
85BCKDK0.61569821
86CAMK40.61452638
87MAP2K30.61327746
88CDK70.61320052
89MAP2K70.61295058
90PDK20.59191402
91BMX0.58013854
92PBK0.57902011
93PDPK10.57408702
94DMPK0.53995855
95RET0.53830339
96MAP3K10.53738627
97PDGFRA0.53545850
98PLK10.53006381
99ATR0.52892119
100PAK10.52335991
101MAP2K60.52063532
102MAPK100.50652624
103PKN10.50415007
104MAP3K80.49445362
105RPS6KB20.49199028
106CSNK1G30.49181309
107DYRK20.48257885
108CHEK10.47688181
109MARK20.47432409
110PRKCG0.46935251
111IRAK30.46480371
112MAP3K120.45989382
113MTOR0.44304225
114AKT20.43518733
115LMTK20.43065482
116NEK60.42823657
117CDK40.42269705
118ACVR1B0.41783350
119PDK10.39762921
120NTRK10.39522248
121RPS6KA10.38574829
122SGK2230.38267842
123SGK4940.38267842
124CDK20.38233395
125CSNK1G20.37839317
126PTK20.37626830
127RPS6KA20.36895301
128CHEK20.36526752
129CAMK10.35769103
130MAPK110.34530364
131PRKG20.33527197
132CDC42BPA0.33076836

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.70869380
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.53305915
3DNA replication_Homo sapiens_hsa030302.52066295
4Synaptic vesicle cycle_Homo sapiens_hsa047212.48280965
5Biosynthesis of amino acids_Homo sapiens_hsa012302.22990444
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.21333595
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.20145240
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13558115
9Oocyte meiosis_Homo sapiens_hsa041142.06065608
10Base excision repair_Homo sapiens_hsa034101.82415510
11Mismatch repair_Homo sapiens_hsa034301.74438238
12RNA transport_Homo sapiens_hsa030131.73806120
13Vitamin B6 metabolism_Homo sapiens_hsa007501.72836578
14Cysteine and methionine metabolism_Homo sapiens_hsa002701.67924214
15Olfactory transduction_Homo sapiens_hsa047401.64121952
16Long-term potentiation_Homo sapiens_hsa047201.63430966
17Carbon metabolism_Homo sapiens_hsa012001.63289466
18Pyruvate metabolism_Homo sapiens_hsa006201.62082086
19Spliceosome_Homo sapiens_hsa030401.57919689
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56531351
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.53337946
22Cardiac muscle contraction_Homo sapiens_hsa042601.50309906
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47155093
24Nicotine addiction_Homo sapiens_hsa050331.46112179
25mRNA surveillance pathway_Homo sapiens_hsa030151.44147609
26Sulfur relay system_Homo sapiens_hsa041221.43574075
27Arginine and proline metabolism_Homo sapiens_hsa003301.36342303
28Circadian entrainment_Homo sapiens_hsa047131.32636910
29VEGF signaling pathway_Homo sapiens_hsa043701.28644571
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25910648
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.24505563
32Glucagon signaling pathway_Homo sapiens_hsa049221.21123594
33Amphetamine addiction_Homo sapiens_hsa050311.20297130
34Fatty acid elongation_Homo sapiens_hsa000621.16486728
35Dopaminergic synapse_Homo sapiens_hsa047281.13360456
36Cell cycle_Homo sapiens_hsa041101.10436282
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08868912
38GABAergic synapse_Homo sapiens_hsa047271.08066836
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08056679
40mTOR signaling pathway_Homo sapiens_hsa041501.07127335
41Oxytocin signaling pathway_Homo sapiens_hsa049211.06799735
42Folate biosynthesis_Homo sapiens_hsa007901.05455375
43Glutamatergic synapse_Homo sapiens_hsa047241.03412691
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03061612
45Gap junction_Homo sapiens_hsa045401.02382620
46Pentose phosphate pathway_Homo sapiens_hsa000301.01856898
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00646055
48Vibrio cholerae infection_Homo sapiens_hsa051100.99748993
49Insulin secretion_Homo sapiens_hsa049110.98690050
50Fructose and mannose metabolism_Homo sapiens_hsa000510.98522662
51Arginine biosynthesis_Homo sapiens_hsa002200.96068084
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95762798
53Thyroid cancer_Homo sapiens_hsa052160.95605096
54GnRH signaling pathway_Homo sapiens_hsa049120.95320419
55Prion diseases_Homo sapiens_hsa050200.94469768
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94268843
57Insulin signaling pathway_Homo sapiens_hsa049100.92952894
58Glioma_Homo sapiens_hsa052140.92098527
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91663129
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90674357
61Estrogen signaling pathway_Homo sapiens_hsa049150.90245099
62Bladder cancer_Homo sapiens_hsa052190.83627826
63Parkinsons disease_Homo sapiens_hsa050120.82838440
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82560169
65Phenylalanine metabolism_Homo sapiens_hsa003600.82200616
66Gastric acid secretion_Homo sapiens_hsa049710.81698277
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80656010
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79970134
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78950052
70Fatty acid metabolism_Homo sapiens_hsa012120.78623097
71Morphine addiction_Homo sapiens_hsa050320.78245064
72Alcoholism_Homo sapiens_hsa050340.77358712
73Salivary secretion_Homo sapiens_hsa049700.75402084
74Alzheimers disease_Homo sapiens_hsa050100.75280877
75Non-small cell lung cancer_Homo sapiens_hsa052230.74959212
76Galactose metabolism_Homo sapiens_hsa000520.73833232
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73361938
78Colorectal cancer_Homo sapiens_hsa052100.72757484
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72616927
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.72492666
81Pyrimidine metabolism_Homo sapiens_hsa002400.71940674
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71432276
83Cholinergic synapse_Homo sapiens_hsa047250.71211741
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69647729
85Bile secretion_Homo sapiens_hsa049760.68135484
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66032787
87Endometrial cancer_Homo sapiens_hsa052130.65774189
88Cocaine addiction_Homo sapiens_hsa050300.65284688
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64374051
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63747629
91Hedgehog signaling pathway_Homo sapiens_hsa043400.63611014
92Type II diabetes mellitus_Homo sapiens_hsa049300.62604730
93HIF-1 signaling pathway_Homo sapiens_hsa040660.60678568
94Selenocompound metabolism_Homo sapiens_hsa004500.60546885
95AMPK signaling pathway_Homo sapiens_hsa041520.60361558
96ErbB signaling pathway_Homo sapiens_hsa040120.59675230
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58851453
98Calcium signaling pathway_Homo sapiens_hsa040200.58202826
99Ribosome_Homo sapiens_hsa030100.57846229
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57322772
101Nucleotide excision repair_Homo sapiens_hsa034200.56486251
102Notch signaling pathway_Homo sapiens_hsa043300.56311829
103Melanogenesis_Homo sapiens_hsa049160.56269589
104Nitrogen metabolism_Homo sapiens_hsa009100.55884800
105RNA degradation_Homo sapiens_hsa030180.53878311
106Long-term depression_Homo sapiens_hsa047300.53433335
107Fatty acid biosynthesis_Homo sapiens_hsa000610.53233025
108Endocytosis_Homo sapiens_hsa041440.53224350
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52889846
110Purine metabolism_Homo sapiens_hsa002300.52796371
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51757070
112Hippo signaling pathway_Homo sapiens_hsa043900.50951952
113Dilated cardiomyopathy_Homo sapiens_hsa054140.50128781
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47823402
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47131043
116Oxidative phosphorylation_Homo sapiens_hsa001900.46534659
117Chronic myeloid leukemia_Homo sapiens_hsa052200.45820655
118Huntingtons disease_Homo sapiens_hsa050160.45817640
119One carbon pool by folate_Homo sapiens_hsa006700.45658230
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45510280
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45190710
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42429997
123cAMP signaling pathway_Homo sapiens_hsa040240.42197934
124Axon guidance_Homo sapiens_hsa043600.37572863

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »