KLHDC10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)4.88927169
2locomotory exploration behavior (GO:0035641)4.68008664
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.51550248
4synaptic vesicle maturation (GO:0016188)4.48901352
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.31050749
6pyrimidine nucleobase catabolic process (GO:0006208)3.99360719
7establishment of mitochondrion localization (GO:0051654)3.78975691
8neuron remodeling (GO:0016322)3.71850059
9vocalization behavior (GO:0071625)3.63988611
10exploration behavior (GO:0035640)3.63834272
11dendritic spine morphogenesis (GO:0060997)3.61164158
12synaptic vesicle docking involved in exocytosis (GO:0016081)3.59145534
13dendrite morphogenesis (GO:0048813)3.57414091
14establishment of nucleus localization (GO:0040023)3.56996728
15activation of protein kinase A activity (GO:0034199)3.56349242
16glutamate secretion (GO:0014047)3.53231081
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.52471530
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.46526968
19axonal fasciculation (GO:0007413)3.44157674
20nucleobase catabolic process (GO:0046113)3.41501724
21regulation of glutamate receptor signaling pathway (GO:1900449)3.39923001
22proline transport (GO:0015824)3.38107145
23neurotransmitter secretion (GO:0007269)3.30532018
24cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.27770222
25neuron recognition (GO:0008038)3.25094184
26cell communication by electrical coupling (GO:0010644)3.23572757
27mitochondrion transport along microtubule (GO:0047497)3.22693343
28establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.22693343
29cerebellar Purkinje cell layer development (GO:0021680)3.21388263
30regulation of synaptic vesicle exocytosis (GO:2000300)3.17564701
31positive regulation of synapse assembly (GO:0051965)3.16715641
32synaptic vesicle exocytosis (GO:0016079)3.13349420
33postsynaptic membrane organization (GO:0001941)3.12969964
34insulin-like growth factor receptor signaling pathway (GO:0048009)3.09434233
35negative regulation of cytosolic calcium ion concentration (GO:0051481)3.08698132
36gamma-aminobutyric acid transport (GO:0015812)3.06921021
37protein localization to synapse (GO:0035418)3.04986775
38presynaptic membrane organization (GO:0097090)3.04129286
39auditory behavior (GO:0031223)3.02131939
40presynaptic membrane assembly (GO:0097105)3.02055310
41sodium ion export (GO:0071436)3.01514603
42positive regulation of synapse maturation (GO:0090129)3.01239113
43cell migration in hindbrain (GO:0021535)3.00053335
44regulation of clathrin-mediated endocytosis (GO:2000369)2.98769043
45regulation of synapse structural plasticity (GO:0051823)2.97183824
46neuron maturation (GO:0042551)2.93271678
47camera-type eye morphogenesis (GO:0048593)2.89491002
48cell differentiation in hindbrain (GO:0021533)2.86093830
49regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.83426974
50regulation of long-term neuronal synaptic plasticity (GO:0048169)2.82723865
51positive regulation of glycogen biosynthetic process (GO:0045725)2.80754767
52cerebellar Purkinje cell differentiation (GO:0021702)2.78957314
53clathrin coat assembly (GO:0048268)2.78025995
54neuron cell-cell adhesion (GO:0007158)2.77016070
55behavioral response to nicotine (GO:0035095)2.76534377
56ionotropic glutamate receptor signaling pathway (GO:0035235)2.76314461
57axon extension (GO:0048675)2.75892119
58ephrin receptor signaling pathway (GO:0048013)2.75156612
59retinal ganglion cell axon guidance (GO:0031290)2.74398730
60membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.74320565
61central nervous system projection neuron axonogenesis (GO:0021952)2.74056013
62neuromuscular process controlling balance (GO:0050885)2.73788294
63regulation of neuronal synaptic plasticity (GO:0048168)2.73469285
64regulation of synaptic vesicle transport (GO:1902803)2.71959800
65cranial nerve morphogenesis (GO:0021602)2.69100708
66alanine transport (GO:0032328)2.68175688
67regulation of synapse assembly (GO:0051963)2.66048088
68regulation of axon guidance (GO:1902667)2.65078091
69cellular potassium ion homeostasis (GO:0030007)2.64701848
70cytoskeletal anchoring at plasma membrane (GO:0007016)2.60567563
71vesicle transport along microtubule (GO:0047496)2.60381316
72dendrite development (GO:0016358)2.57018027
73positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.54883758
74mechanosensory behavior (GO:0007638)2.54592996
75neuronal action potential propagation (GO:0019227)2.53135855
76neurotransmitter-gated ion channel clustering (GO:0072578)2.52675757
77innervation (GO:0060384)2.52598359
78cell communication involved in cardiac conduction (GO:0086065)2.52330447
79positive regulation of glycogen metabolic process (GO:0070875)2.51754769
80suckling behavior (GO:0001967)2.51145009
81organelle transport along microtubule (GO:0072384)2.50983387
82neurotransmitter transport (GO:0006836)2.49057686
83long-term memory (GO:0007616)2.47005669
84body morphogenesis (GO:0010171)2.46458140
85negative regulation of sodium ion transport (GO:0010766)2.45239147
86cerebral cortex radially oriented cell migration (GO:0021799)2.44363033
87embryonic retina morphogenesis in camera-type eye (GO:0060059)2.43950198
88response to pheromone (GO:0019236)2.43939653
89cellular sodium ion homeostasis (GO:0006883)2.43851571
90regulation of dendritic spine morphogenesis (GO:0061001)2.43850925
91regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.43545918
92synapse assembly (GO:0007416)2.42051115
93glutamate receptor signaling pathway (GO:0007215)2.41555123
94regulation of ARF protein signal transduction (GO:0032012)2.40724276
95membrane repolarization during action potential (GO:0086011)2.40085576
96transmission of nerve impulse (GO:0019226)2.40041241
97synaptic transmission, glutamatergic (GO:0035249)2.39644677
98inner ear receptor cell development (GO:0060119)2.37505678
99neuron projection extension involved in neuron projection guidance (GO:1902284)2.37305005
100axon extension involved in axon guidance (GO:0048846)2.37305005
101neuron projection extension (GO:1990138)2.37036805
102regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.36947159
103plasma membrane repair (GO:0001778)2.36705231
104negative regulation of dendrite morphogenesis (GO:0050774)2.36343572
105social behavior (GO:0035176)2.36258907
106intraspecies interaction between organisms (GO:0051703)2.36258907
107positive regulation of axon extension (GO:0045773)2.35159980
108regulation of synapse organization (GO:0050807)2.34657957
109regulation of neurotransmitter levels (GO:0001505)2.33964357
110membrane depolarization during action potential (GO:0086010)2.33767294
111dendritic spine organization (GO:0097061)2.33096658
112cochlea development (GO:0090102)2.33089254
113neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.32524876
114glial cell proliferation (GO:0014009)2.31692048
115neuronal ion channel clustering (GO:0045161)2.31086932
116negative regulation of microtubule polymerization (GO:0031115)2.30968860
117negative regulation of catenin import into nucleus (GO:0035414)2.30559296
118apical protein localization (GO:0045176)2.30352368
119membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.29784132
120regulation of glycogen (starch) synthase activity (GO:2000465)2.29718175
121adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.29607072
122cerebellar granule cell differentiation (GO:0021707)2.29607019
123dicarboxylic acid biosynthetic process (GO:0043650)2.28414516
124regulation of fatty acid beta-oxidation (GO:0031998)2.26736434
125regulation of axon extension involved in axon guidance (GO:0048841)2.26468362
126positive regulation of dendritic spine morphogenesis (GO:0061003)2.26249974
127nucleus localization (GO:0051647)2.26163745
128synapse organization (GO:0050808)2.25755393
129regulation of cAMP-dependent protein kinase activity (GO:2000479)2.25472991
130nerve growth factor signaling pathway (GO:0038180)2.25298710
131stress granule assembly (GO:0034063)2.25265170
132negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.25188993
133positive regulation of nitric-oxide synthase activity (GO:0051000)2.24850339
134axon cargo transport (GO:0008088)2.23702627
135lysine metabolic process (GO:0006553)2.23452952
136lysine catabolic process (GO:0006554)2.23452952
137glycine transport (GO:0015816)2.23266082
138prepulse inhibition (GO:0060134)2.23074602
139negative regulation of neurotransmitter secretion (GO:0046929)2.22885163
140response to parathyroid hormone (GO:0071107)2.19869455
141phosphorelay signal transduction system (GO:0000160)2.18852163
142negative regulation of potassium ion transmembrane transport (GO:1901380)2.18607377
143potassium ion homeostasis (GO:0055075)2.18592371
144neuromuscular synaptic transmission (GO:0007274)2.16735809
145regulation of respiratory system process (GO:0044065)2.16529447
146metanephric mesenchyme development (GO:0072075)2.15225337
147regulation of synapse maturation (GO:0090128)2.14084423
148startle response (GO:0001964)2.13324861
149spinal cord development (GO:0021510)2.13253311
150positive regulation of dendritic spine development (GO:0060999)2.13140747

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.55809043
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.48666309
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42902569
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38200157
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32317027
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32317027
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32110453
8DROSHA_22980978_ChIP-Seq_HELA_Human2.24667674
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.23822246
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20479237
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20257526
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07055069
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05042772
14ZNF274_21170338_ChIP-Seq_K562_Hela2.01307973
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.01275597
16GBX2_23144817_ChIP-Seq_PC3_Human2.01003556
17* RARB_27405468_Chip-Seq_BRAIN_Mouse1.99135119
18REST_21632747_ChIP-Seq_MESCs_Mouse1.95897747
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95883437
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95645366
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94296847
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92238416
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90356309
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87531710
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.87436246
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82703806
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.81796428
28TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.78299924
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.78171605
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76914161
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.72471816
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72033725
33RNF2_27304074_Chip-Seq_NSC_Mouse1.70726942
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.67978972
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64443978
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.61450139
37TAF15_26573619_Chip-Seq_HEK293_Human1.56522555
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55232029
39KDM2B_26808549_Chip-Seq_K562_Human1.54377672
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51495295
41DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.50964767
42FUS_26573619_Chip-Seq_HEK293_Human1.46335847
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45624779
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43780788
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41471259
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40322913
47AR_21572438_ChIP-Seq_LNCaP_Human1.38485338
48* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38243641
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38149532
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38045194
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37802231
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.37758459
53TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36210523
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35915880
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.35601158
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.35520202
57AR_19668381_ChIP-Seq_PC3_Human1.35331815
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35174481
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34776539
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.32608418
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32460144
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31156822
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28351345
64RING1B_27294783_Chip-Seq_NPCs_Mouse1.28217495
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26697388
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26408221
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26286019
68* SMAD4_21799915_ChIP-Seq_A2780_Human1.23935312
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22708825
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21999048
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.21652405
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.21260941
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21011709
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20263910
75TCF4_23295773_ChIP-Seq_U87_Human1.19835941
76* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19198196
77AHR_22903824_ChIP-Seq_MCF-7_Human1.18216778
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18171901
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18171901
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17895797
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17557908
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17130896
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16685349
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15304335
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15230805
86STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14847407
87* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14013893
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13466972
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12858017
90ESR1_20079471_ChIP-ChIP_T-47D_Human1.12699024
91EP300_21415370_ChIP-Seq_HL-1_Mouse1.12597238
92ISL1_27105846_Chip-Seq_CPCs_Mouse1.12309775
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12135911
94NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11002204
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10238702
96TP53_20018659_ChIP-ChIP_R1E_Mouse1.10101207
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09799195
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07604354
99ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07213304
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07126828
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07121347
102SMAD4_21741376_ChIP-Seq_HESCs_Human1.05494530
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.03360414
104CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03200441
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02480125
106JUN_21703547_ChIP-Seq_K562_Human1.01876996
107SOX9_26525672_Chip-Seq_HEART_Mouse1.01333967
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01183309
109GATA1_26923725_Chip-Seq_HPCs_Mouse1.00963369
110RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00660998
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00087561
112P300_19829295_ChIP-Seq_ESCs_Human0.98798717
113STAT3_23295773_ChIP-Seq_U87_Human0.98214609
114NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97857731
115SMAD3_21741376_ChIP-Seq_EPCs_Human0.97651947
116* FOXA2_19822575_ChIP-Seq_HepG2_Human0.97540576
117KDM2B_26808549_Chip-Seq_JURKAT_Human0.97050704
118NANOG_18555785_Chip-Seq_ESCs_Mouse0.96613570
119TP53_16413492_ChIP-PET_HCT116_Human0.96448234
120KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95530527
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95353830
122SMAD3_21741376_ChIP-Seq_ESCs_Human0.94620101
123ER_23166858_ChIP-Seq_MCF-7_Human0.93549772
124* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93128545
125AR_25329375_ChIP-Seq_VCAP_Human0.92752335
126CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92362199
127CBX2_27304074_Chip-Seq_ESCs_Mouse0.92077758
128FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91847699
129CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91829754
130* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91299610
131NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90837404
132ZNF263_19887448_ChIP-Seq_K562_Human0.89961844
133IGF1R_20145208_ChIP-Seq_DFB_Human0.89087132
134CREB1_26743006_Chip-Seq_LNCaP_Human0.87381571
135GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87099211
136* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86787791

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.75552902
2MP0003122_maternal_imprinting3.12901122
3MP0003635_abnormal_synaptic_transmissio2.89487228
4MP0009780_abnormal_chondrocyte_physiolo2.64299323
5MP0004270_analgesia2.38524068
6MP0003283_abnormal_digestive_organ2.37662577
7MP0002063_abnormal_learning/memory/cond2.25543579
8MP0000569_abnormal_digit_pigmentation2.17750805
9MP0003123_paternal_imprinting2.02321545
10MP0002909_abnormal_adrenal_gland1.89179346
11MP0003705_abnormal_hypodermis_morpholog1.87530597
12MP0009745_abnormal_behavioral_response1.85035489
13MP0003880_abnormal_central_pattern1.84195978
14MP0000778_abnormal_nervous_system1.83592402
15MP0009046_muscle_twitch1.82213853
16MP0000537_abnormal_urethra_morphology1.81299105
17MP0002638_abnormal_pupillary_reflex1.77098577
18MP0004858_abnormal_nervous_system1.73636240
19MP0002064_seizures1.69016109
20MP0005423_abnormal_somatic_nervous1.68226613
21MP0003121_genomic_imprinting1.67485545
22MP0002184_abnormal_innervation1.66321672
23MP0005187_abnormal_penis_morphology1.63906504
24MP0002572_abnormal_emotion/affect_behav1.63445410
25MP0010234_abnormal_vibrissa_follicle1.62459130
26MP0005248_abnormal_Harderian_gland1.61598045
27MP0003890_abnormal_embryonic-extraembry1.56569960
28MP0002734_abnormal_mechanical_nocicepti1.55600711
29MP0000751_myopathy1.53731910
30MP0004811_abnormal_neuron_physiology1.52101857
31MP0004130_abnormal_muscle_cell1.45469113
32MP0005623_abnormal_meninges_morphology1.44577886
33MP0002139_abnormal_hepatobiliary_system1.43784331
34MP0004885_abnormal_endolymph1.42993072
35MP0005409_darkened_coat_color1.42239427
36MP0002837_dystrophic_cardiac_calcinosis1.41550061
37MP0001486_abnormal_startle_reflex1.40916432
38MP0001968_abnormal_touch/_nociception1.39701009
39MP0004233_abnormal_muscle_weight1.38856772
40MP0002557_abnormal_social/conspecific_i1.38279742
41MP0001299_abnormal_eye_distance/1.38267812
42MP0000955_abnormal_spinal_cord1.37940270
43MP0008961_abnormal_basal_metabolism1.36284261
44MP0000013_abnormal_adipose_tissue1.31073504
45MP0003329_amyloid_beta_deposits1.30089409
46MP0001502_abnormal_circadian_rhythm1.29551689
47MP0005360_urolithiasis1.28370043
48MP0002733_abnormal_thermal_nociception1.27097969
49MP0004145_abnormal_muscle_electrophysio1.25114529
50MP0002234_abnormal_pharynx_morphology1.23493675
51MP0003787_abnormal_imprinting1.22558553
52MP0003252_abnormal_bile_duct1.22098588
53MP0005365_abnormal_bile_salt1.22046945
54MP0002067_abnormal_sensory_capabilities1.21876889
55MP0001440_abnormal_grooming_behavior1.21175401
56MP0000534_abnormal_ureter_morphology1.21173315
57MP0004924_abnormal_behavior1.18039021
58MP0005386_behavior/neurological_phenoty1.18039021
59MP0000566_synostosis1.17452097
60MP0002152_abnormal_brain_morphology1.16405083
61MP0002272_abnormal_nervous_system1.15544030
62MP0003119_abnormal_digestive_system1.09757399
63MP0003942_abnormal_urinary_system1.09674399
64MP0002882_abnormal_neuron_morphology1.08962977
65MP0003937_abnormal_limbs/digits/tail_de1.08184090
66MP0004142_abnormal_muscle_tone1.04489417
67MP0002735_abnormal_chemical_nociception1.03767124
68MP0006276_abnormal_autonomic_nervous1.03307771
69MP0008569_lethality_at_weaning1.03041387
70MP0001984_abnormal_olfaction1.01925540
71MP0002066_abnormal_motor_capabilities/c1.01749109
72MP0002896_abnormal_bone_mineralization1.01391235
73MP0005499_abnormal_olfactory_system1.01039801
74MP0005394_taste/olfaction_phenotype1.01039801
75MP0001529_abnormal_vocalization0.99366011
76MP0003385_abnormal_body_wall0.97807594
77MP0003879_abnormal_hair_cell0.96532122
78MP0009053_abnormal_anal_canal0.95341079
79MP0005167_abnormal_blood-brain_barrier0.95095617
80MP0001501_abnormal_sleep_pattern0.94691107
81MP0009379_abnormal_foot_pigmentation0.94663825
82MP0000383_abnormal_hair_follicle0.94639202
83MP0003861_abnormal_nervous_system0.94629271
84MP0005085_abnormal_gallbladder_physiolo0.94228007
85MP0003115_abnormal_respiratory_system0.94191404
86MP0002752_abnormal_somatic_nervous0.94037106
87MP0001970_abnormal_pain_threshold0.91364766
88MP0000003_abnormal_adipose_tissue0.90699433
89MP0010386_abnormal_urinary_bladder0.90159789
90MP0001188_hyperpigmentation0.89877815
91MP0004085_abnormal_heartbeat0.89706112
92MP0009672_abnormal_birth_weight0.88676683
93MP0004215_abnormal_myocardial_fiber0.87630934
94MP0000427_abnormal_hair_cycle0.87511884
95MP0004133_heterotaxia0.87141530
96MP0002249_abnormal_larynx_morphology0.87117054
97MP0003633_abnormal_nervous_system0.86186439
98MP0003632_abnormal_nervous_system0.85904614
99MP0001177_atelectasis0.85392382
100MP0005646_abnormal_pituitary_gland0.84482376
101MP0003755_abnormal_palate_morphology0.83088531
102MP0000747_muscle_weakness0.82594582
103MP0009703_decreased_birth_body0.82376167
104MP0000631_abnormal_neuroendocrine_gland0.81942205
105MP0005076_abnormal_cell_differentiation0.81898848
106MP0002233_abnormal_nose_morphology0.81593615
107MP0002160_abnormal_reproductive_system0.81570985
108MP0008789_abnormal_olfactory_epithelium0.81433241
109MP0010329_abnormal_lipoprotein_level0.81380880
110MP0005645_abnormal_hypothalamus_physiol0.81086860
111MP0001293_anophthalmia0.80904166
112MP0002822_catalepsy0.80066182
113MP0003137_abnormal_impulse_conducting0.79617433
114MP0004272_abnormal_basement_membrane0.79356016
115MP0005083_abnormal_biliary_tract0.79058386
116MP0003938_abnormal_ear_development0.79049205
117MP0002069_abnormal_eating/drinking_beha0.78863841
118MP0002736_abnormal_nociception_after0.78591551
119MP0005551_abnormal_eye_electrophysiolog0.78437125
120MP0001905_abnormal_dopamine_level0.75911371
121MP0001849_ear_inflammation0.75896779
122MP0000049_abnormal_middle_ear0.74697238
123MP0003935_abnormal_craniofacial_develop0.74636932
124MP0001286_abnormal_eye_development0.74612958
125MP0003634_abnormal_glial_cell0.74505284
126MP0002089_abnormal_postnatal_growth/wei0.74354468
127MP0002697_abnormal_eye_size0.73922954
128MP0002928_abnormal_bile_duct0.73917448
129MP0000579_abnormal_nail_morphology0.72090219
130MP0010678_abnormal_skin_adnexa0.71156154
131MP0005195_abnormal_posterior_eye0.70763471
132MP0003868_abnormal_feces_composition0.69927880
133MP0002108_abnormal_muscle_morphology0.69835304
134MP0000026_abnormal_inner_ear0.69238001
135MP0004134_abnormal_chest_morphology0.69145442
136MP0004043_abnormal_pH_regulation0.69057026
137MP0003631_nervous_system_phenotype0.68672957
138MP0002081_perinatal_lethality0.67101389
139MP0004087_abnormal_muscle_fiber0.66640492
140MP0002078_abnormal_glucose_homeostasis0.63693743
141MP0005375_adipose_tissue_phenotype0.62928201

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)3.26796873
2Elfin facies (HP:0004428)3.07772443
3Hyperacusis (HP:0010780)3.00917287
4Focal seizures (HP:0007359)2.99844241
5Hepatoblastoma (HP:0002884)2.80131525
6Limb dystonia (HP:0002451)2.80057464
7Myokymia (HP:0002411)2.79223737
8Renal duplication (HP:0000075)2.78445660
9Abnormality of the lower motor neuron (HP:0002366)2.77696820
10Insomnia (HP:0100785)2.77651768
11Macroorchidism (HP:0000053)2.77334097
12Renovascular hypertension (HP:0100817)2.72538081
13Focal motor seizures (HP:0011153)2.68113512
14Action tremor (HP:0002345)2.68035584
15Agitation (HP:0000713)2.64296724
16Lymphangioma (HP:0100764)2.59255231
17Enlarged penis (HP:0000040)2.58455076
18Papilledema (HP:0001085)2.56533679
19Termporal pattern (HP:0011008)2.49507455
20Insidious onset (HP:0003587)2.49507455
21Genetic anticipation (HP:0003743)2.47830061
22Impaired social interactions (HP:0000735)2.42112437
23Abnormal social behavior (HP:0012433)2.42112437
24Short 4th metacarpal (HP:0010044)2.40098354
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.40098354
26Exotropia (HP:0000577)2.39554493
27Drooling (HP:0002307)2.36361113
28Excessive salivation (HP:0003781)2.36361113
29Poor eye contact (HP:0000817)2.35231618
30Mutism (HP:0002300)2.29612739
31Subacute progressive viral hepatitis (HP:0006572)2.23619529
32Progressive cerebellar ataxia (HP:0002073)2.22769991
33Pheochromocytoma (HP:0002666)2.22751295
34Depression (HP:0000716)2.22606862
35Overriding aorta (HP:0002623)2.20011271
36Fetal akinesia sequence (HP:0001989)2.19534849
37Osteomalacia (HP:0002749)2.18733115
38Impaired vibration sensation in the lower limbs (HP:0002166)2.18029039
39Gait imbalance (HP:0002141)2.17616840
40Abnormality of the 4th metacarpal (HP:0010012)2.16410712
41Supranuclear gaze palsy (HP:0000605)2.12794618
42Shallow orbits (HP:0000586)2.12437715
43Turricephaly (HP:0000262)2.11821994
44Pointed chin (HP:0000307)2.11464837
45Urinary bladder sphincter dysfunction (HP:0002839)2.10255525
46Dysmetric saccades (HP:0000641)2.07653037
47Ankyloglossia (HP:0010296)2.06289809
48Prolonged QT interval (HP:0001657)2.04187239
49Abnormal hair whorl (HP:0010721)2.03482429
50Sacral dimple (HP:0000960)2.03174970
51Buphthalmos (HP:0000557)2.02995369
52Protruding tongue (HP:0010808)2.01661124
53Generalized tonic-clonic seizures (HP:0002069)2.01001848
54Megalencephaly (HP:0001355)2.00544284
55Ankle clonus (HP:0011448)1.99732125
56Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.96389722
57Obsessive-compulsive behavior (HP:0000722)1.95191926
58Flat cornea (HP:0007720)1.94427049
59Heterotopia (HP:0002282)1.93675044
60Amyotrophic lateral sclerosis (HP:0007354)1.92298414
61Abnormality of the diencephalon (HP:0010662)1.92233140
62Urinary urgency (HP:0000012)1.91973077
63Vertebral arch anomaly (HP:0008438)1.90928898
64Febrile seizures (HP:0002373)1.90416816
65Overgrowth (HP:0001548)1.90177110
66Bronchomalacia (HP:0002780)1.90126629
67Torticollis (HP:0000473)1.90101798
68Deep venous thrombosis (HP:0002625)1.89510897
69Bundle branch block (HP:0011710)1.88696673
70Bowel diverticulosis (HP:0005222)1.88650288
71Intellectual disability, moderate (HP:0002342)1.87594672
72Status epilepticus (HP:0002133)1.87114292
73Absence seizures (HP:0002121)1.86640939
74Concave nail (HP:0001598)1.86194952
75Postural instability (HP:0002172)1.84628581
76Epileptic encephalopathy (HP:0200134)1.84353751
77Hypsarrhythmia (HP:0002521)1.83862735
78Poor coordination (HP:0002370)1.83135646
79Volvulus (HP:0002580)1.82903843
80Curly hair (HP:0002212)1.82726308
81Neurofibrillary tangles (HP:0002185)1.81799274
82Menstrual irregularities (HP:0000858)1.80867318
83Shawl scrotum (HP:0000049)1.80507095
84Neoplasm of the heart (HP:0100544)1.80480183
85Dysdiadochokinesis (HP:0002075)1.80297050
86EEG with generalized epileptiform discharges (HP:0011198)1.79808976
87Broad-based gait (HP:0002136)1.79680488
88Asymmetry of the thorax (HP:0001555)1.78718844
89Hamartoma of the eye (HP:0010568)1.78691724
90Hemiplegia (HP:0002301)1.78120443
91Akinesia (HP:0002304)1.78079495
92Pancreatic fibrosis (HP:0100732)1.77771884
93Degeneration of the lateral corticospinal tracts (HP:0002314)1.76499668
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76499668
95Apathy (HP:0000741)1.75704434
96Hypoventilation (HP:0002791)1.75491875
97Hyperventilation (HP:0002883)1.74574251
98Intellectual disability, profound (HP:0002187)1.74520886
99True hermaphroditism (HP:0010459)1.73797047
100Epileptiform EEG discharges (HP:0011182)1.73488693
101Polyphagia (HP:0002591)1.73432061
102Atonic seizures (HP:0010819)1.73027413
103Cerebral inclusion bodies (HP:0100314)1.72995310
104Impaired smooth pursuit (HP:0007772)1.72957541
105Ventricular fibrillation (HP:0001663)1.72148855
106Long toe (HP:0010511)1.70853220
107Infantile muscular hypotonia (HP:0008947)1.70144689
108Abnormality of the corticospinal tract (HP:0002492)1.69796284
109Inappropriate behavior (HP:0000719)1.68918394
110Truncal ataxia (HP:0002078)1.68686013
111Papillary thyroid carcinoma (HP:0002895)1.68422948
112Chronic hepatic failure (HP:0100626)1.68220896
113Hyperphosphatemia (HP:0002905)1.67124241
114Anxiety (HP:0000739)1.65539443
115Cerebral aneurysm (HP:0004944)1.65500458
116Hyperthyroidism (HP:0000836)1.65477348
117Focal dystonia (HP:0004373)1.65204001
118Morphological abnormality of the pyramidal tract (HP:0002062)1.65167512
119Abnormal eating behavior (HP:0100738)1.65158609
120Broad metatarsal (HP:0001783)1.64743764
121Cortical dysplasia (HP:0002539)1.64718065
122Postural tremor (HP:0002174)1.63903969
123Truncal obesity (HP:0001956)1.62443461
124Germ cell neoplasia (HP:0100728)1.62391841
125Sleep apnea (HP:0010535)1.62109443
126Bladder diverticulum (HP:0000015)1.61906768
127Lower limb asymmetry (HP:0100559)1.61643780
128Absent speech (HP:0001344)1.61502048
129Blue irides (HP:0000635)1.61409206
130Exostoses (HP:0100777)1.61186301
131Deviation of the hallux (HP:0010051)1.60975673
132Ketoacidosis (HP:0001993)1.60186374
133Back pain (HP:0003418)1.59409239
134Cutaneous finger syndactyly (HP:0010554)1.58296870
135Hypoplasia of the corpus callosum (HP:0002079)1.58294535
136Cutaneous syndactyly (HP:0012725)1.57796831
137Congenital primary aphakia (HP:0007707)1.57459172
138Neuroendocrine neoplasm (HP:0100634)1.55508605
139Hypoplasia of the brainstem (HP:0002365)1.55423248
140Aplasia/Hypoplasia of the brainstem (HP:0007362)1.55423248
141Abnormality of salivation (HP:0100755)1.55395630
142Amblyopia (HP:0000646)1.52290913
143Nephrogenic diabetes insipidus (HP:0009806)1.50519734
144Nephronophthisis (HP:0000090)1.49080232
145Syncope (HP:0001279)1.47403444
146Bowel incontinence (HP:0002607)1.47355332
147High anterior hairline (HP:0009890)1.47312986
148Obstructive sleep apnea (HP:0002870)1.46708538
149Vaginal atresia (HP:0000148)1.46621609
150Abnormal pancreas size (HP:0012094)1.44954302
151Spastic gait (HP:0002064)1.44814931
152Spastic tetraplegia (HP:0002510)1.43858243
153Medial flaring of the eyebrow (HP:0010747)1.43827178
154Hyperkalemia (HP:0002153)1.43801337
155Myotonia (HP:0002486)1.41697040
156Pachygyria (HP:0001302)1.41162019
157Genital tract atresia (HP:0001827)1.40015929
158Abnormality of the labia minora (HP:0012880)1.39741438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.27406656
2MARK13.96950832
3TRIB33.18478893
4NTRK32.94581554
5MAP3K92.71935508
6PKN22.62270123
7MAP3K42.56452596
8MINK12.14746077
9MAP2K42.04499687
10PRKD32.04348723
11TNIK1.96297826
12CAMKK11.79709048
13LATS21.78005411
14NTRK21.73687080
15KSR11.72501420
16PAK61.72498674
17RIPK11.71528008
18PDGFRA1.71329742
19DAPK21.63194440
20NTRK11.54453424
21EPHA41.50338714
22PHKG11.48190426
23PHKG21.48190426
24KSR21.46640273
25MAP2K71.46177952
26BRSK21.44539096
27CAMK1G1.39399039
28NEK11.38398245
29PINK11.35412567
30TYRO31.34235290
31LATS11.29843534
32SCYL21.28979135
33MAP3K21.27844642
34RET1.27392869
35MAP3K61.24058917
36SIK21.22987385
37SIK11.22124597
38STK381.22066442
39DDR21.19401153
40OBSCN1.17245432
41ALK1.17063180
42PTK61.13156097
43FGFR21.12069326
44INSRR1.10027630
45DYRK21.09885259
46PAK31.09270342
47ICK1.04515869
48LMTK21.03463564
49PNCK1.03410662
50PRKCH1.02479902
51MAP3K101.01820817
52CDK50.99828585
53MAPK130.99344261
54SGK30.98182103
55UHMK10.95504383
56AKT30.92606138
57BMX0.91648715
58STK110.89360025
59EPHB20.87810897
60FER0.86167680
61CAMK1D0.84225695
62CSNK1G20.81343213
63CDK190.80025714
64ERBB30.79033816
65EPHA30.77253085
66BRSK10.77072298
67SGK20.76643247
68EEF2K0.76078833
69TAOK10.72815730
70FRK0.72041214
71WNK30.71389566
72PLK20.71254543
73SGK2230.70820964
74SGK4940.70820964
75PDK30.70374630
76PDK40.70374630
77MAPKAPK50.70277795
78PKN10.69777211
79RPS6KB10.65916222
80RPS6KA20.65796899
81CDC42BPA0.64834224
82PRKCG0.64770298
83FGFR10.64597459
84PDGFRB0.64480239
85PRKCZ0.63627202
86MTOR0.62860610
87MAP3K70.62310278
88TTN0.62017818
89CAMKK20.61403500
90ERBB20.59657285
91CAMK2B0.59287918
92DYRK1B0.59193853
93DMPK0.56319283
94PTK20.56205503
95DAPK10.54300051
96PRKAA10.53932578
97BCR0.53702762
98DYRK30.53343460
99SGK10.53291255
100MARK20.53013166
101CSNK1A1L0.52089831
102CAMK10.52059560
103WNK10.50771809
104RPS6KA30.50666457
105PDPK10.50474333
106PRKACB0.49552025
107ROCK10.48211074
108CDK140.47277892
109EPHB10.47224798
110WNK40.46160622
111PDK10.46106444
112CDK150.45460395
113WEE10.45220400
114MAP2K10.45212340
115MET0.44743463
116PRKDC0.44593606
117CDK180.44153549
118GSK3B0.43878914
119PRKCE0.43597250
120DYRK1A0.43408602
121TNK20.41985761
122PRKACA0.41844632
123CAMK40.41010976
124MAPK100.40599538
125CSNK1D0.39964167
126MAPK140.38275509
127PRPF4B0.37526398
128CAMK2A0.37464413
129CDK11A0.37433357
130CSNK1E0.37342266
131MAPK120.36810329

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.56777657
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02059448
3Nicotine addiction_Homo sapiens_hsa050331.98676090
4Long-term potentiation_Homo sapiens_hsa047201.82389429
5Synaptic vesicle cycle_Homo sapiens_hsa047211.77022696
6GABAergic synapse_Homo sapiens_hsa047271.75109551
7Circadian entrainment_Homo sapiens_hsa047131.69787947
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68045969
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.65280044
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58260087
11Glutamatergic synapse_Homo sapiens_hsa047241.56730010
12Insulin secretion_Homo sapiens_hsa049111.55883646
13Dopaminergic synapse_Homo sapiens_hsa047281.52552342
14Type II diabetes mellitus_Homo sapiens_hsa049301.51979709
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50709821
16Amphetamine addiction_Homo sapiens_hsa050311.48676654
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47262946
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47188352
19Olfactory transduction_Homo sapiens_hsa047401.42424705
20Arginine biosynthesis_Homo sapiens_hsa002201.41445080
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38576499
22Gastric acid secretion_Homo sapiens_hsa049711.36090874
23Glioma_Homo sapiens_hsa052141.35496769
24Estrogen signaling pathway_Homo sapiens_hsa049151.34888615
25Morphine addiction_Homo sapiens_hsa050321.34657039
26Phenylalanine metabolism_Homo sapiens_hsa003601.34147408
27Bile secretion_Homo sapiens_hsa049761.30779274
28Butanoate metabolism_Homo sapiens_hsa006501.28774709
29Cholinergic synapse_Homo sapiens_hsa047251.28104646
30Salivary secretion_Homo sapiens_hsa049701.25660161
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24003848
32Gap junction_Homo sapiens_hsa045401.21901349
33Endometrial cancer_Homo sapiens_hsa052131.20464407
34Renin secretion_Homo sapiens_hsa049241.20307471
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19259183
36Axon guidance_Homo sapiens_hsa043601.18602153
37Long-term depression_Homo sapiens_hsa047301.15524743
38GnRH signaling pathway_Homo sapiens_hsa049121.15297267
39Oxytocin signaling pathway_Homo sapiens_hsa049211.14966169
40Cardiac muscle contraction_Homo sapiens_hsa042601.14625762
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14492310
42Cocaine addiction_Homo sapiens_hsa050301.12725325
43mTOR signaling pathway_Homo sapiens_hsa041501.10080425
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08542920
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06020639
46Melanogenesis_Homo sapiens_hsa049161.04927558
47Glucagon signaling pathway_Homo sapiens_hsa049221.02088225
48Insulin signaling pathway_Homo sapiens_hsa049101.01045739
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00536621
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99959059
51Circadian rhythm_Homo sapiens_hsa047100.98919536
52Dorso-ventral axis formation_Homo sapiens_hsa043200.97142673
53Lysine degradation_Homo sapiens_hsa003100.95292100
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95100563
55ErbB signaling pathway_Homo sapiens_hsa040120.94508821
56Taste transduction_Homo sapiens_hsa047420.93188786
57Tyrosine metabolism_Homo sapiens_hsa003500.92087106
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91797075
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90899639
60cAMP signaling pathway_Homo sapiens_hsa040240.90796891
61Dilated cardiomyopathy_Homo sapiens_hsa054140.89889545
62Thyroid hormone synthesis_Homo sapiens_hsa049180.89517461
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88749893
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.86667829
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.84041997
66Insulin resistance_Homo sapiens_hsa049310.81887716
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81386824
68AMPK signaling pathway_Homo sapiens_hsa041520.80321335
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79451062
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78481562
71Pancreatic secretion_Homo sapiens_hsa049720.77215663
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.75571359
73Non-small cell lung cancer_Homo sapiens_hsa052230.75515301
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75486923
75Calcium signaling pathway_Homo sapiens_hsa040200.75099168
76Propanoate metabolism_Homo sapiens_hsa006400.73303212
77Oocyte meiosis_Homo sapiens_hsa041140.72904311
78Steroid biosynthesis_Homo sapiens_hsa001000.72277697
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71929209
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71434851
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69962415
82Adherens junction_Homo sapiens_hsa045200.68712743
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.68615588
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68571213
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67986259
86beta-Alanine metabolism_Homo sapiens_hsa004100.67931787
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67801443
88Prolactin signaling pathway_Homo sapiens_hsa049170.67043838
89Renal cell carcinoma_Homo sapiens_hsa052110.66402129
90Serotonergic synapse_Homo sapiens_hsa047260.65392885
91Ras signaling pathway_Homo sapiens_hsa040140.65229831
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.64630690
93Linoleic acid metabolism_Homo sapiens_hsa005910.64263807
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63819893
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63128337
96Colorectal cancer_Homo sapiens_hsa052100.62787625
97VEGF signaling pathway_Homo sapiens_hsa043700.62442656
98Retinol metabolism_Homo sapiens_hsa008300.61872642
99Phototransduction_Homo sapiens_hsa047440.61141699
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59977135
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59599403
102Chronic myeloid leukemia_Homo sapiens_hsa052200.59011682
103Inositol phosphate metabolism_Homo sapiens_hsa005620.58788235
104Caffeine metabolism_Homo sapiens_hsa002320.58657714
105Tight junction_Homo sapiens_hsa045300.58643803
106Fatty acid metabolism_Homo sapiens_hsa012120.58250282
107Focal adhesion_Homo sapiens_hsa045100.58041057
108Fatty acid degradation_Homo sapiens_hsa000710.57987933
109Hedgehog signaling pathway_Homo sapiens_hsa043400.57792755
110Proteoglycans in cancer_Homo sapiens_hsa052050.57634657
111Fatty acid biosynthesis_Homo sapiens_hsa000610.56986286
112Tryptophan metabolism_Homo sapiens_hsa003800.56563524
113Choline metabolism in cancer_Homo sapiens_hsa052310.56556349
114Hippo signaling pathway_Homo sapiens_hsa043900.56446529
115Prion diseases_Homo sapiens_hsa050200.56386058
116ECM-receptor interaction_Homo sapiens_hsa045120.54953604
117MAPK signaling pathway_Homo sapiens_hsa040100.54668915
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.54037350
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53815937
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53774900
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.52851721
122Protein digestion and absorption_Homo sapiens_hsa049740.52448046
123FoxO signaling pathway_Homo sapiens_hsa040680.52087766
124Melanoma_Homo sapiens_hsa052180.51826752
125Basal cell carcinoma_Homo sapiens_hsa052170.51462907
126PPAR signaling pathway_Homo sapiens_hsa033200.51426096
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50461069
128Wnt signaling pathway_Homo sapiens_hsa043100.48582139

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