KLF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.59657196
2hemidesmosome assembly (GO:0031581)6.43944615
3establishment of skin barrier (GO:0061436)6.27188735
4regulation of water loss via skin (GO:0033561)6.06022126
5regulation of Wnt signaling pathway involved in heart development (GO:0003307)5.39043237
6response to peptidoglycan (GO:0032494)4.96524319
7keratinization (GO:0031424)4.85279691
8lymph vessel development (GO:0001945)4.81648733
9keratinocyte proliferation (GO:0043616)4.63188305
10bundle of His cell to Purkinje myocyte communication (GO:0086069)4.55331177
11neutrophil activation involved in immune response (GO:0002283)4.34365710
12multicellular organismal water homeostasis (GO:0050891)4.26118944
13keratinocyte differentiation (GO:0030216)4.22792728
14negative regulation of erythrocyte differentiation (GO:0045647)4.21188955
15interferon-gamma secretion (GO:0072643)4.20190811
16regulation of cell proliferation involved in kidney development (GO:1901722)4.16052128
17regulation of chemokine secretion (GO:0090196)4.09051378
18negative regulation of cell fate specification (GO:0009996)4.04319815
19epithelial cell-cell adhesion (GO:0090136)4.03158434
20atrioventricular valve morphogenesis (GO:0003181)4.00280806
21response to muramyl dipeptide (GO:0032495)3.82385472
22negative regulation of cell fate commitment (GO:0010454)3.78367306
23cellular extravasation (GO:0045123)3.70101586
24cell fate commitment involved in formation of primary germ layer (GO:0060795)3.60236166
25sphingoid metabolic process (GO:0046519)3.43749649
26surfactant homeostasis (GO:0043129)3.42142832
27water homeostasis (GO:0030104)3.42137483
28* epidermal cell differentiation (GO:0009913)3.38434240
29regulation of cell fate specification (GO:0042659)3.35105743
30positive regulation by symbiont of host defense response (GO:0052509)3.33826931
31modulation by symbiont of host defense response (GO:0052031)3.33826931
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.33826931
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.33826931
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.33826931
35modulation by symbiont of host immune response (GO:0052553)3.33826931
36molting cycle (GO:0042303)3.33561444
37hair cycle (GO:0042633)3.33561444
38embryonic process involved in female pregnancy (GO:0060136)3.33149540
39dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.31453871
40peptide cross-linking (GO:0018149)3.30842921
41notochord development (GO:0030903)3.30396881
42skin morphogenesis (GO:0043589)3.28584550
43positive regulation of interleukin-8 secretion (GO:2000484)3.27911856
44epidermis development (GO:0008544)3.27590760
45intestinal epithelial cell development (GO:0060576)3.17079847
46negative regulation of stress fiber assembly (GO:0051497)3.16247695
47regulation of cardioblast differentiation (GO:0051890)3.16231662
48macrophage activation involved in immune response (GO:0002281)3.14295773
49transcytosis (GO:0045056)3.11863440
50limb bud formation (GO:0060174)3.11338101
51positive regulation of glomerulus development (GO:0090193)3.10982639
52positive regulation of gamma-delta T cell activation (GO:0046645)3.09129850
53regulation of mast cell degranulation (GO:0043304)3.08799591
54detection of external biotic stimulus (GO:0098581)3.08137491
55regulation of T-helper 2 cell differentiation (GO:0045628)3.07508918
56regulation of phospholipase A2 activity (GO:0032429)3.05726682
57chemical homeostasis within a tissue (GO:0048875)3.03852579
58regulation of dendritic cell antigen processing and presentation (GO:0002604)3.01717835
59heart valve morphogenesis (GO:0003179)3.01191838
60negative regulation of keratinocyte proliferation (GO:0010839)3.00412655
61regulation of leukocyte degranulation (GO:0043300)3.00011269
62viral transcription (GO:0019083)2.99277524
63keratinocyte development (GO:0003334)2.96523655
64detection of biotic stimulus (GO:0009595)2.96421544
65cell surface receptor signaling pathway involved in heart development (GO:0061311)2.95833559
66diol metabolic process (GO:0034311)2.94647264
67response to progesterone (GO:0032570)2.94125459
68regulation of myeloid leukocyte mediated immunity (GO:0002886)2.93837698
69immunoglobulin mediated immune response (GO:0016064)2.91509001
70ribosomal small subunit biogenesis (GO:0042274)2.90496395
71negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.90358199
72mannose metabolic process (GO:0006013)2.89952537
73* response to laminar fluid shear stress (GO:0034616)2.87601709
74vascular endothelial growth factor signaling pathway (GO:0038084)2.87429216
75detection of bacterium (GO:0016045)2.83595623
76neutrophil activation (GO:0042119)2.82044666
77endothelium development (GO:0003158)2.81799974
78intermediate filament organization (GO:0045109)2.79811143
79regulation of mast cell activation involved in immune response (GO:0033006)2.79654542
80negative regulation of interleukin-12 production (GO:0032695)2.79343657
81phospholipid scrambling (GO:0017121)2.79279238
82renal system process involved in regulation of blood volume (GO:0001977)2.78410179
83antigen processing and presentation of endogenous antigen (GO:0019883)2.77411564
84detection of other organism (GO:0098543)2.77214818
85regulation of interleukin-8 secretion (GO:2000482)2.75956552
86macrophage activation (GO:0042116)2.73944822
87translational termination (GO:0006415)2.73318127
88cardiac right ventricle morphogenesis (GO:0003215)2.72418770
89ectoderm development (GO:0007398)2.71844983
90cyclooxygenase pathway (GO:0019371)2.71342533
91positive regulation of Cdc42 GTPase activity (GO:0043089)2.70835660
92sphingosine metabolic process (GO:0006670)2.70805365
93granulocyte activation (GO:0036230)2.70733892
94G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.70683599
95positive regulation of type 2 immune response (GO:0002830)2.69274200
96negative regulation of interleukin-6 production (GO:0032715)2.68768700
97gland morphogenesis (GO:0022612)2.68022860
98glomerular visceral epithelial cell development (GO:0072015)2.67038955
99positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.64565718
100regulation of transforming growth factor beta1 production (GO:0032908)2.63431471
101regulation of glomerular filtration (GO:0003093)2.63363227
102neural crest cell development (GO:0014032)2.63116681
103positive regulation of cellular amide metabolic process (GO:0034250)2.62157088
104establishment of endothelial barrier (GO:0061028)2.62008454
105mRNA transcription (GO:0009299)2.61655133
106* negative regulation of interleukin-8 production (GO:0032717)2.61431796
107regulation of glomerulus development (GO:0090192)2.61151667
108cell wall macromolecule catabolic process (GO:0016998)2.58335980
109regulation of cell fate commitment (GO:0010453)2.58242943
110regulation of mast cell activation (GO:0033003)2.57692312
111regulation of gamma-delta T cell activation (GO:0046643)2.57692009
112detection of molecule of bacterial origin (GO:0032490)2.56920676
113pinocytosis (GO:0006907)2.55601371
114positive regulation of mast cell activation (GO:0033005)2.54233082
115regulation of integrin-mediated signaling pathway (GO:2001044)2.52958852
116glomerular basement membrane development (GO:0032836)2.49147409
117regulation of gene silencing by RNA (GO:0060966)2.49120158
118regulation of posttranscriptional gene silencing (GO:0060147)2.49120158
119regulation of gene silencing by miRNA (GO:0060964)2.49120158
120positive regulation of leukocyte degranulation (GO:0043302)2.47971129
121neutrophil mediated immunity (GO:0002446)2.47562248
122cellular response to thyroid hormone stimulus (GO:0097067)2.47416383
123microglial cell activation (GO:0001774)2.46545725
124negative regulation of toll-like receptor signaling pathway (GO:0034122)2.46302998
125regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.45835934
126positive regulation of odontogenesis (GO:0042482)2.45619742
127mitotic cell cycle arrest (GO:0071850)2.45531838
128mRNA transcription from RNA polymerase II promoter (GO:0042789)2.45054128
129positive regulation of mast cell degranulation (GO:0043306)2.44619334
130positive regulation of mast cell activation involved in immune response (GO:0033008)2.44619334
131regulation of ruffle assembly (GO:1900027)2.43597368
132virion attachment to host cell (GO:0019062)2.42942371
133adhesion of symbiont to host cell (GO:0044650)2.42942371
134negative regulation of fatty acid transport (GO:2000192)2.42328919
135phosphatidylserine acyl-chain remodeling (GO:0036150)2.42326214
136regulation of interleukin-6 production (GO:0032675)2.41959127
137positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.39843364
138germinal center formation (GO:0002467)2.39450823
139cell-substrate junction assembly (GO:0007044)2.38908868
140radial glial cell differentiation (GO:0060019)2.37251117
141regulation of type 2 immune response (GO:0002828)2.36801326
142regulation of regulated secretory pathway (GO:1903305)2.36031617
143negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.35960515
144lipopolysaccharide-mediated signaling pathway (GO:0031663)2.35708269
145regulation of p38MAPK cascade (GO:1900744)2.35330674
146positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.35109524
147lateral sprouting from an epithelium (GO:0060601)2.34950116
148peptide catabolic process (GO:0043171)2.34865333
149face development (GO:0060324)2.34509083
150endocardial cushion morphogenesis (GO:0003203)2.34265963
151negative regulation of chondrocyte differentiation (GO:0032331)2.33747682
152endothelial cell morphogenesis (GO:0001886)2.33722999
153regulation of antigen processing and presentation (GO:0002577)2.33187186
154adhesion of symbiont to host (GO:0044406)2.32209149
155regulation of vitamin metabolic process (GO:0030656)2.32187199
156regulation of cardioblast proliferation (GO:0003264)2.31801814
157regulation of secondary heart field cardioblast proliferation (GO:0003266)2.31801814
158regulation of interferon-beta biosynthetic process (GO:0045357)2.31634845
159eyelid development in camera-type eye (GO:0061029)2.31473287
160CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.31463771
161T-helper cell differentiation (GO:0042093)2.31463771
162planar cell polarity pathway involved in neural tube closure (GO:0090179)2.31215935
163positive regulation of chemokine secretion (GO:0090197)2.31036796
164antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.30629600
165lipoxygenase pathway (GO:0019372)2.29955755
166glomerular epithelial cell development (GO:0072310)2.29091784
167myeloid cell activation involved in immune response (GO:0002275)2.28970064
168regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.26122831
169regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.25556028
170positive regulation of fatty acid beta-oxidation (GO:0032000)2.24919464
171wound healing, spreading of epidermal cells (GO:0035313)2.23918792
172regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.23074347
173production of molecular mediator of immune response (GO:0002440)2.22145745
174regulation of tolerance induction (GO:0002643)2.21451249
175positive regulation of interleukin-1 beta secretion (GO:0050718)2.21212016
176positive regulation of antigen processing and presentation (GO:0002579)2.19833941
177positive regulation of interleukin-6 production (GO:0032755)2.19577023
178negative regulation of T cell mediated immunity (GO:0002710)2.19229101
179response to fungus (GO:0009620)2.18827695
180positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.18790716
181regulation of tumor necrosis factor production (GO:0032680)2.16265994
182negative regulation of tumor necrosis factor production (GO:0032720)2.16087665

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.61872545
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.74402797
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.16568540
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.16337893
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.07547795
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.81258327
7* KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.65963463
8* KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.65963463
9* KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.65963463
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.56656858
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40567754
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33366574
13SOX9_24532713_ChIP-Seq_HFSC_Mouse2.31620408
14VDR_21846776_ChIP-Seq_THP-1_Human2.22114538
15* VDR_24763502_ChIP-Seq_THP-1_Human2.19856393
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.12159329
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.09737101
18* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07711608
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05134236
20TP63_17297297_ChIP-ChIP_HaCaT_Human11.3058672
21IRF8_27001747_Chip-Seq_BMDM_Mouse1.98830007
22* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.94924537
23* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.94924537
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92196898
25P63_26484246_Chip-Seq_KERATINOCYTES_Human1.91726929
26* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.91609933
27* CDX2_20551321_ChIP-Seq_CACO-2_Human1.89535841
28KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88527094
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84892970
30* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84290796
31* FOXO3_23340844_ChIP-Seq_DLD1_Human1.83933860
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80986468
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.79770030
34TCF7_22412390_ChIP-Seq_EML_Mouse1.77539592
35SOX2_20726797_ChIP-Seq_SW620_Human1.76721837
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76558530
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.76274053
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72810194
39CJUN_26792858_Chip-Seq_BT549_Human1.66537491
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61820963
41VDR_24787735_ChIP-Seq_THP-1_Human1.61557981
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60256434
43TCF4_18268006_ChIP-ChIP_LS174T_Human1.60043051
44CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.58152109
45SCL_19346495_ChIP-Seq_HPC-7_Human1.57316719
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56881788
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56313143
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55528196
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.55458098
50* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52819294
51* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52117631
52STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48141493
53* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46420789
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.45994620
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45253301
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41217131
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38503901
58* LXR_22292898_ChIP-Seq_THP-1_Human1.38301857
59KDM2B_26808549_Chip-Seq_DND41_Human1.38187665
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.36177600
61KLF5_25053715_ChIP-Seq_YYC3_Human1.36123059
62RUNX_20019798_ChIP-Seq_JUKART_Human1.35359557
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35089038
64TP53_18474530_ChIP-ChIP_U2OS_Human1.34161094
65PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32534674
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.32111173
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.31390348
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29773210
69* AHR_22903824_ChIP-Seq_MCF-7_Human1.28479786
70TP53_16413492_ChIP-PET_HCT116_Human1.27795911
71FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26950442
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.26477230
73* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25869179
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25845669
75RXR_22158963_ChIP-Seq_LIVER_Mouse1.24484684
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24100133
77* RUNX1_27514584_Chip-Seq_MCF-7_Human1.21653390
78CLOCK_20551151_ChIP-Seq_293T_Human1.20593575
79* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19590998
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18858324
81SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18158090
82MAF_26560356_Chip-Seq_TH1_Human1.17168242
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16832543
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15914080
85LXR_22158963_ChIP-Seq_LIVER_Mouse1.14492856
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13830572
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12832390
88* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12706596
89SPI1_23127762_ChIP-Seq_K562_Human1.11590234
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11545220
91GATA4_25053715_ChIP-Seq_YYC3_Human1.09824224
92KDM2B_26808549_Chip-Seq_K562_Human1.08179001
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07483762
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05314457
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04890915
96TP53_20018659_ChIP-ChIP_R1E_Mouse1.04389424
97TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04343647
98SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02987902
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.02752999
100TBX20_22328084_ChIP-Seq_HEART_Mouse1.02752999
101* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02703276
102* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02661852
103EED_16625203_ChIP-ChIP_MESCs_Mouse1.02407238
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02263360
105KDM2B_26808549_Chip-Seq_JURKAT_Human1.01866490
106* TP63_23658742_ChIP-Seq_EP156T_Human1.01689875
107SPI1_23547873_ChIP-Seq_NB4_Human1.01630141
108* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00816963
109RACK7_27058665_Chip-Seq_MCF-7_Human1.00615687
110AR_21572438_ChIP-Seq_LNCaP_Human0.99989384
111NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98256754
112EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98138533
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97839161
114* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97298964
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96505346
116* GATA1_19941826_ChIP-Seq_K562_Human0.96461640
117UTX_26944678_Chip-Seq_JUKART_Human0.96387408
118NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95931105
119PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94376200
120UBF1/2_26484160_Chip-Seq_HMECs_Human0.94110363
121ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93892592
122MYB_26560356_Chip-Seq_TH2_Human0.93536612
123* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93441445
124SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93163133
125* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93106622
126SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92515679
127* ARNT_22903824_ChIP-Seq_MCF-7_Human0.92319592
128* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91305201
129* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90831587
130RXR_22108803_ChIP-Seq_LS180_Human0.90710412
131GATA3_24758297_ChIP-Seq_MCF-7_Human0.89828686
132* ATF3_27146783_Chip-Seq_COLON_Human0.88268891
133* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87589744
134FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87372208
135NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85931954
136* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82579269
137* SMAD3_21741376_ChIP-Seq_HESCs_Human0.81302211
138GATA6_25053715_ChIP-Seq_YYC3_Human0.79973449
139RING1B_27294783_Chip-Seq_NPCs_Mouse0.78942001
140ELK3_25401928_ChIP-Seq_HUVEC_Human0.78888042
141EP300_21415370_ChIP-Seq_HL-1_Mouse0.78835698
142SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.78486152
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77982484
144BMI1_23680149_ChIP-Seq_NPCS_Mouse0.76632253
145BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75208284
146FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74419209
147SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.73543820
148ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.73233027
149BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72647558
150UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.72557545
151* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72401631
152ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.72148070
153EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.70702391
154POU5F1_16153702_ChIP-ChIP_HESCs_Human0.70682298
155* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70177897
156* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70177897

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development5.46928401
2* MP0002796_impaired_skin_barrier4.99938277
3MP0010234_abnormal_vibrissa_follicle4.38933500
4MP0005275_abnormal_skin_tensile4.30974015
5MP0002254_reproductive_system_inflammat3.24536586
6* MP0005501_abnormal_skin_physiology3.21248916
7MP0004381_abnormal_hair_follicle3.05278894
8* MP0002060_abnormal_skin_morphology2.92596095
9MP0003436_decreased_susceptibility_to2.75563934
10MP0002098_abnormal_vibrissa_morphology2.74126550
11MP0003453_abnormal_keratinocyte_physiol2.71374245
12MP0003303_peritoneal_inflammation2.64707015
13* MP0001216_abnormal_epidermal_layer2.64415610
14MP0010678_abnormal_skin_adnexa2.43994943
15MP0000383_abnormal_hair_follicle2.33458890
16MP0003566_abnormal_cell_adhesion2.18873284
17MP0003136_yellow_coat_color2.16233044
18* MP0010771_integument_phenotype2.16076339
19MP0001835_abnormal_antigen_presentation2.03349572
20MP0005058_abnormal_lysosome_morphology2.02895411
21MP0000579_abnormal_nail_morphology2.01580052
22* MP0000762_abnormal_tongue_morphology2.00924321
23MP0001346_abnormal_lacrimal_gland1.98535564
24MP0004272_abnormal_basement_membrane1.97570342
25MP0002419_abnormal_innate_immunity1.97135264
26MP0004947_skin_inflammation1.91193648
27MP0000377_abnormal_hair_follicle1.88091263
28MP0000647_abnormal_sebaceous_gland1.87120511
29MP0009379_abnormal_foot_pigmentation1.84907839
30MP0003705_abnormal_hypodermis_morpholog1.80586754
31MP0006082_CNS_inflammation1.79874530
32MP0003828_pulmonary_edema1.73581039
33MP0005025_abnormal_response_to1.72592077
34* MP0000467_abnormal_esophagus_morphology1.71713069
35MP0003878_abnormal_ear_physiology1.71086409
36MP0005377_hearing/vestibular/ear_phenot1.71086409
37MP0002249_abnormal_larynx_morphology1.67463552
38MP0001958_emphysema1.63833074
39MP0005451_abnormal_body_composition1.61552877
40MP0002148_abnormal_hypersensitivity_rea1.61034887
41MP0003724_increased_susceptibility_to1.57622623
42MP0008260_abnormal_autophagy1.57485016
43MP0005167_abnormal_blood-brain_barrier1.54657702
44MP0002998_abnormal_bone_remodeling1.50831921
45MP0000566_synostosis1.50173825
46MP0005000_abnormal_immune_tolerance1.50110909
47MP0009785_altered_susceptibility_to1.49841778
48MP0009840_abnormal_foam_cell1.46361978
49MP0001853_heart_inflammation1.45551774
50MP0005387_immune_system_phenotype1.44469041
51MP0001790_abnormal_immune_system1.44469041
52MP0008438_abnormal_cutaneous_collagen1.44119520
53MP0010030_abnormal_orbit_morphology1.42988976
54MP0001243_abnormal_dermal_layer1.41387923
55MP0001800_abnormal_humoral_immune1.40501300
56MP0002452_abnormal_antigen_presenting1.40169545
57MP0005623_abnormal_meninges_morphology1.38888265
58MP0005166_decreased_susceptibility_to1.36348448
59MP0003075_altered_response_to1.35757061
60MP0000685_abnormal_immune_system1.31271703
61MP0010352_gastrointestinal_tract_polyps1.29114986
62MP0001849_ear_inflammation1.26733131
63MP0008004_abnormal_stomach_pH1.26695434
64MP0002723_abnormal_immune_serum1.26173455
65MP0001191_abnormal_skin_condition1.25742256
66* MP0009931_abnormal_skin_appearance1.24460212
67MP0000516_abnormal_urinary_system1.23814803
68MP0005367_renal/urinary_system_phenotyp1.23814803
69MP0001851_eye_inflammation1.23788654
70MP0003091_abnormal_cell_migration1.23360613
71MP0005508_abnormal_skeleton_morphology1.21738513
72MP0001879_abnormal_lymphatic_vessel1.20373124
73MP0002420_abnormal_adaptive_immunity1.19789364
74MP0003950_abnormal_plasma_membrane1.18833109
75MP0001819_abnormal_immune_cell1.18743743
76MP0009250_abnormal_appendicular_skeleto1.18645716
77MP0002282_abnormal_trachea_morphology1.17480381
78MP0005666_abnormal_adipose_tissue1.16747448
79MP0005023_abnormal_wound_healing1.13562844
80MP0001845_abnormal_inflammatory_respons1.12725296
81MP0000858_altered_metastatic_potential1.12051162
82MP0005397_hematopoietic_system_phenotyp1.11450007
83MP0001545_abnormal_hematopoietic_system1.11450007
84MP0004185_abnormal_adipocyte_glucose1.11063656
85MP0005670_abnormal_white_adipose1.09879340
86MP0002132_abnormal_respiratory_system1.06791688
87MP0000249_abnormal_blood_vessel1.06307015
88MP0002405_respiratory_system_inflammati1.05642001
89MP0005503_abnormal_tendon_morphology1.05504562
90MP0005076_abnormal_cell_differentiation1.03999867
91MP0009384_cardiac_valve_regurgitation1.03636854
92MP0001542_abnormal_bone_strength1.02244890
93MP0004782_abnormal_surfactant_physiolog1.02017884
94MP0005360_urolithiasis1.01858833
95MP0000537_abnormal_urethra_morphology1.00755765
96MP0003172_abnormal_lysosome_physiology0.99922778
97MP0006054_spinal_hemorrhage0.99118913
98MP0002277_abnormal_respiratory_mucosa0.98006889
99MP0009333_abnormal_splenocyte_physiolog0.97731537
100MP0005165_increased_susceptibility_to0.97643055
101MP0002877_abnormal_melanocyte_morpholog0.97173510
102MP0003300_gastrointestinal_ulcer0.94529941
103MP0004264_abnormal_extraembryonic_tissu0.94468174
104MP0010368_abnormal_lymphatic_system0.93875171
105MP0003283_abnormal_digestive_organ0.93777146
106MP0000767_abnormal_smooth_muscle0.91936367
107MP0000613_abnormal_salivary_gland0.91002457
108MP0000343_altered_response_to0.90942192
109MP0004510_myositis0.89049709
110MP0008469_abnormal_protein_level0.88607659
111MP0003183_abnormal_peptide_metabolism0.88327699
112* MP0002166_altered_tumor_susceptibility0.88243563
113MP0005388_respiratory_system_phenotype0.87779969
114MP0002133_abnormal_respiratory_system0.87779969
115MP0001340_abnormal_eyelid_morphology0.87113451
116MP0010155_abnormal_intestine_physiology0.87092738
117MP0001986_abnormal_taste_sensitivity0.86542886
118MP0002896_abnormal_bone_mineralization0.86295723
119MP0003866_abnormal_defecation0.85458101
120MP0009764_decreased_sensitivity_to0.84966721
121MP0000049_abnormal_middle_ear0.84908967
122MP0005464_abnormal_platelet_physiology0.83497868
123MP0000427_abnormal_hair_cycle0.83036528
124MP0003755_abnormal_palate_morphology0.82721280
125MP0006138_congestive_heart_failure0.82265463
126MP0005390_skeleton_phenotype0.81527620
127MP0002933_joint_inflammation0.80817402
128MP0004883_abnormal_blood_vessel0.80483421
129MP0003763_abnormal_thymus_physiology0.80171200
130MP0002295_abnormal_pulmonary_circulatio0.77783453
131MP0005375_adipose_tissue_phenotype0.74627172
132MP0000716_abnormal_immune_system0.74328288
133MP0009115_abnormal_fat_cell0.74180953
134MP0002233_abnormal_nose_morphology0.73761215
135* MP0000367_abnormal_coat/_hair0.73701997
136MP0004808_abnormal_hematopoietic_stem0.73266121
137MP0002234_abnormal_pharynx_morphology0.71960428
138MP0003937_abnormal_limbs/digits/tail_de0.71809383
139MP0000678_abnormal_parathyroid_gland0.71549299
140MP0001873_stomach_inflammation0.71531783
141* MP0000470_abnormal_stomach_morphology0.70938259
142MP0000432_abnormal_head_morphology0.70898724
143MP0000163_abnormal_cartilage_morphology0.70489989
144MP0009278_abnormal_bone_marrow0.69597661
145MP0004484_altered_response_of0.68665100
146MP0005164_abnormal_response_to0.68071085
147MP0000465_gastrointestinal_hemorrhage0.67961403
148* MP0001784_abnormal_fluid_regulation0.64267572
149MP0003279_aneurysm0.63451116
150MP0005257_abnormal_intraocular_pressure0.63103536
151MP0001533_abnormal_skeleton_physiology0.61994544
152MP0002108_abnormal_muscle_morphology0.61906839
153MP0003191_abnormal_cellular_cholesterol0.61504621
154MP0003448_altered_tumor_morphology0.60734584
155MP0005409_darkened_coat_color0.60716582
156MP0000627_abnormal_mammary_gland0.60589253
157MP0003045_fibrosis0.59362539

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.17191018
2Hypotrichosis (HP:0001006)4.97924587
3Parakeratosis (HP:0001036)4.81860672
4Eczematoid dermatitis (HP:0000976)4.64796380
5Fragile nails (HP:0001808)4.61530920
6Plantar hyperkeratosis (HP:0007556)4.39579118
7Woolly hair (HP:0002224)4.29055233
8Onycholysis (HP:0001806)4.24366400
9Amyloidosis (HP:0011034)4.07725569
10Distal lower limb muscle weakness (HP:0009053)4.06300516
11Milia (HP:0001056)4.06081473
12Congenital ichthyosiform erythroderma (HP:0007431)3.97444394
13Atrophic scars (HP:0001075)3.80730586
14Increased IgE level (HP:0003212)3.73755147
15Abnormality of macrophages (HP:0004311)3.71618406
16Lip pit (HP:0100267)3.71127177
17Recurrent bacterial skin infections (HP:0005406)3.65262501
18Congenital, generalized hypertrichosis (HP:0004540)3.44450080
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.38835890
20Recurrent abscess formation (HP:0002722)3.38759296
21Palmoplantar hyperkeratosis (HP:0000972)3.35972139
22Alopecia of scalp (HP:0002293)3.31959309
23Malnutrition (HP:0004395)3.31918972
24Palmar hyperkeratosis (HP:0010765)3.20459322
25Aplasia cutis congenita (HP:0001057)3.12133534
26Acanthosis nigricans (HP:0000956)3.12068454
27Elevated erythrocyte sedimentation rate (HP:0003565)3.04693952
28Abnormality of nail color (HP:0100643)3.03758284
29Myositis (HP:0100614)2.98348635
30Ectropion (HP:0000656)2.97737333
31Premature rupture of membranes (HP:0001788)2.92921268
32Systemic lupus erythematosus (HP:0002725)2.86144074
33Neonatal short-limb short stature (HP:0008921)2.83816738
34Esophageal atresia (HP:0002032)2.83775619
35Natal tooth (HP:0000695)2.81672476
36Nail dystrophy (HP:0008404)2.78217190
37Ventricular tachycardia (HP:0004756)2.75194254
38Stenosis of the external auditory canal (HP:0000402)2.72123819
39Abnormality of secondary sexual hair (HP:0009888)2.65749925
40Abnormality of the axillary hair (HP:0100134)2.65749925
41Upper limb muscle weakness (HP:0003484)2.62012316
42Orchitis (HP:0100796)2.60049861
43Thick nail (HP:0001805)2.58632115
44Advanced eruption of teeth (HP:0006288)2.56927300
45Interstitial pulmonary disease (HP:0006530)2.56063949
46Sparse eyelashes (HP:0000653)2.55573529
47Follicular hyperkeratosis (HP:0007502)2.51112346
48Hyperactive renin-angiotensin system (HP:0000841)2.50305331
49Spondylolisthesis (HP:0003302)2.50114365
50Abnormal blistering of the skin (HP:0008066)2.49465940
51Recurrent gram-negative bacterial infections (HP:0005420)2.49307835
52Abnormality of the 2nd finger (HP:0004100)2.48471111
53Fragile skin (HP:0001030)2.48224599
54Ulnar claw (HP:0001178)2.46729860
55Erythroderma (HP:0001019)2.43311709
56Dysostosis multiplex (HP:0000943)2.42670253
57Recurrent skin infections (HP:0001581)2.42365409
58Hypohidrosis (HP:0000966)2.42093068
59Osteolytic defects of the hand bones (HP:0009699)2.41197136
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.41197136
61Gingivitis (HP:0000230)2.40591197
62Down-sloping shoulders (HP:0200021)2.39176672
63Erythema (HP:0010783)2.37228680
64Pterygium (HP:0001059)2.36825460
65Short hallux (HP:0010109)2.35392532
66Sparse scalp hair (HP:0002209)2.33474353
67Pili torti (HP:0003777)2.32428859
68Corneal erosion (HP:0200020)2.31307884
69Optic neuritis (HP:0100653)2.28742103
70Retrobulbar optic neuritis (HP:0100654)2.28742103
71Abnormality of the middle phalanges of the toes (HP:0010183)2.25289235
72Abnormality of cells of the erythroid lineage (HP:0012130)2.25085336
73Curly hair (HP:0002212)2.24750967
74Popliteal pterygium (HP:0009756)2.22835582
75Keratoconjunctivitis sicca (HP:0001097)2.21961538
76Urticaria (HP:0001025)2.20860189
77Abnormality of glycolipid metabolism (HP:0010969)2.18012156
78Abnormality of liposaccharide metabolism (HP:0010968)2.18012156
79Abnormality of glycosphingolipid metabolism (HP:0004343)2.18012156
80Stomatitis (HP:0010280)2.17270760
81Oligodontia (HP:0000677)2.16877589
82Aortic aneurysm (HP:0004942)2.16558416
83Axonal loss (HP:0003447)2.15817724
84Abnormal vertebral ossification (HP:0100569)2.14222508
85Polygenic inheritance (HP:0010982)2.14100074
86Hypoplasia of dental enamel (HP:0006297)2.13637168
87Increased cerebral lipofuscin (HP:0011813)2.13407816
88Myocardial infarction (HP:0001658)2.13377669
89Prostate neoplasm (HP:0100787)2.13164320
90Colitis (HP:0002583)2.12603124
91Increased connective tissue (HP:0009025)2.11662212
92Pruritus (HP:0000989)2.10358836
93Abnormality of the distal phalanges of the toes (HP:0010182)2.10286816
94Thin bony cortex (HP:0002753)2.10234548
95Aplasia/Hypoplasia of the hallux (HP:0008362)2.08963968
96Hematochezia (HP:0002573)2.08856710
97Concave nail (HP:0001598)2.08798615
98Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.08067065
99Broad face (HP:0000283)2.08003464
100Abnormality of complement system (HP:0005339)2.06366990
101Stomach cancer (HP:0012126)2.05314366
102Hyporeflexia of lower limbs (HP:0002600)2.05235306
103Hemoptysis (HP:0002105)2.03304781
104Abnormality of the phalanges of the 2nd finger (HP:0009541)2.02448565
105Hip contracture (HP:0003273)2.00272591
106Spontaneous hematomas (HP:0007420)1.99971755
107Distal lower limb amyotrophy (HP:0008944)1.99705596
108Xerostomia (HP:0000217)1.96859826
109Mucopolysacchariduria (HP:0008155)1.96376404
110Urinary glycosaminoglycan excretion (HP:0003541)1.96376404
111Polycythemia (HP:0001901)1.95504212
112Keratoconjunctivitis (HP:0001096)1.94225089
113Hypertriglyceridemia (HP:0002155)1.94140616
114Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.93933805
115Vertebral hypoplasia (HP:0008417)1.93933805
116Abnormality of polysaccharide metabolism (HP:0011012)1.93922399
117Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93922399
118Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93922399
119Corneal dystrophy (HP:0001131)1.93456078
120Hypergammaglobulinemia (HP:0010702)1.93197635
121Spinal rigidity (HP:0003306)1.93151216
122Dilatation of the ascending aorta (HP:0005111)1.91940593
123Conical tooth (HP:0000698)1.91409848
124Vertebral clefting (HP:0008428)1.90707819
125Symphalangism affecting the phalanges of the hand (HP:0009773)1.90486989
126Anhidrosis (HP:0000970)1.90221096
127Gangrene (HP:0100758)1.89955779
128Abnormal hemoglobin (HP:0011902)1.89587495
129Blepharitis (HP:0000498)1.89444037
130Abnormality of monocarboxylic acid metabolism (HP:0010996)1.89203279
131Cellulitis (HP:0100658)1.88930525
132Increased serum ferritin (HP:0003281)1.87325355
133Mediastinal lymphadenopathy (HP:0100721)1.87302680
134Vacuolated lymphocytes (HP:0001922)1.86941311
135Cervical subluxation (HP:0003308)1.86825060
136Gastrointestinal infarctions (HP:0005244)1.86525049
137Inflammation of the large intestine (HP:0002037)1.86174985
138Cerebral aneurysm (HP:0004944)1.85938092
139Asymmetric septal hypertrophy (HP:0001670)1.85299168
140Aplasia involving bones of the extremities (HP:0009825)1.85131430
141Aplasia involving bones of the upper limbs (HP:0009823)1.85131430
142Aplasia of the phalanges of the hand (HP:0009802)1.85131430
143Episodic fever (HP:0001954)1.85013903
144Recurrent fungal infections (HP:0002841)1.84961952
145Hypodontia (HP:0000668)1.84870457
146Protrusio acetabuli (HP:0003179)1.84680752
147Decreased circulating renin level (HP:0003351)1.84350660
148Pulmonary infiltrates (HP:0002113)1.81587868
149Pustule (HP:0200039)1.81396974
150Vasculitis (HP:0002633)1.79875382
151Loss of speech (HP:0002371)1.78894950
152Prolonged bleeding time (HP:0003010)1.78756197
153Premature loss of primary teeth (HP:0006323)1.78282618
154Cheilitis (HP:0100825)1.77875332
155Abnormal number of erythroid precursors (HP:0012131)1.77582296
156Gastrointestinal inflammation (HP:0004386)1.77152078
157Recurrent cutaneous fungal infections (HP:0011370)1.75447140
158Chronic mucocutaneous candidiasis (HP:0002728)1.75447140
159Double outlet right ventricle (HP:0001719)1.75056445
160Congenital malformation of the right heart (HP:0011723)1.75056445
161Skin ulcer (HP:0200042)1.74640557
162Abnormality of the salivary glands (HP:0010286)1.74558793
163Abnormality of the gastric mucosa (HP:0004295)1.72899605
164Bone cyst (HP:0012062)1.72624362
165Flat acetabular roof (HP:0003180)1.70475358
166Segmental peripheral demyelination/remyelination (HP:0003481)1.69833008
167Hypoplastic labia majora (HP:0000059)1.69725438
168Ridged nail (HP:0001807)1.68535071
169Skin pits (HP:0100276)1.67954440
170Absent eyebrow (HP:0002223)1.67481643
171Limited hip movement (HP:0008800)1.67260773
172Gastrointestinal atresia (HP:0002589)1.66729328
173Absent toe (HP:0010760)1.66219313
174Abnormality of the fetal cardiovascular system (HP:0010948)1.65619563
175Single umbilical artery (HP:0001195)1.65619563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.95214966
2MST1R3.98462298
3MAPK153.55518516
4MAP2K23.45045023
5PRPF4B3.24083705
6EPHB22.87512553
7PIM22.86215263
8RIPK42.83984770
9BLK2.69002172
10TIE12.60610909
11NUAK12.46273723
12RIPK12.45460669
13EPHA22.36792524
14MAPKAPK32.35038705
15MAP3K32.30639514
16FER2.22735806
17ERN12.21682662
18DMPK2.13107745
19RPS6KB21.97108467
20PIK3CA1.87908606
21MAP2K31.83086748
22TGFBR21.80729896
23MET1.79388566
24MAP3K61.68958220
25ZAP701.64237973
26MAP3K131.62300176
27IRAK41.62166619
28GRK11.57550118
29MAP3K141.56652216
30TRPM71.56308902
31EPHB11.44498165
32MOS1.40860717
33STK101.39520404
34MAP3K21.37024155
35PDK21.36049782
36TRIB31.35573853
37KIT1.34156162
38MAPKAPK51.32649097
39STK38L1.31759414
40IRAK11.28674409
41FES1.26317202
42DDR21.25462233
43IKBKB1.19509241
44SIK11.16920613
45MAP3K71.16314849
46PIM11.14934018
47LATS11.14748330
48GRK61.14587547
49TEC1.12810490
50IRAK21.11492058
51MAPK121.09345400
52KDR1.05977323
53PDPK11.04890335
54EPHA31.03430338
55PTK61.03215950
56MAP2K11.02747250
57JAK31.00915443
58JAK10.99930460
59BCR0.99324754
60CDK60.97579333
61IRAK30.97534805
62AKT30.96981105
63MAP4K10.96617429
64STK240.96553960
65CDC42BPA0.95981426
66CSF1R0.95663067
67TTN0.93857303
68NEK60.86179259
69CDK30.85724489
70ABL20.85586189
71PAK20.84446014
72RPS6KA20.84141209
73GSK3A0.83119847
74TAOK20.82885192
75MARK20.82656408
76PIK3CG0.80783029
77LRRK20.80561035
78MAPK70.79870173
79DYRK1B0.79009877
80HCK0.78644921
81LMTK20.78549782
82PRKG20.78188941
83MAPKAPK20.77702832
84RPS6KC10.77295603
85RPS6KL10.77295603
86FGFR20.74984735
87PDK10.73086349
88CHUK0.72726851
89STK30.71632812
90BTK0.69364408
91CSK0.69088490
92JAK20.68292854
93EEF2K0.68116282
94IKBKE0.66987054
95ACVR1B0.66322057
96BMX0.65928757
97TAOK10.65029377
98MTOR0.64740103
99KSR20.64717579
100NLK0.63063653
101RPS6KA60.61223608
102PRKD10.60432320
103ITK0.59931904
104TYK20.56461695
105MATK0.54825421
106RAF10.54507742
107TNK20.54145064
108SYK0.53901344
109PRKD20.53659964
110PRKCI0.52650616
111PRKCE0.52279971
112FRK0.51691776
113GRK70.50019050
114INSRR0.49524485
115ICK0.49191623
116YES10.48827237
117TBK10.48119662
118PDGFRB0.47830228
119BMPR1B0.46640437
120ILK0.46430344
121PAK40.46039383
122PKN10.45506780
123TGFBR10.43659900
124LYN0.42885438
125CDK120.41837783
126ERBB40.41694238
127PBK0.41392660
128ROCK10.41351273
129ROCK20.40940083
130FGFR40.40033781
131MAPK30.39288833
132MYLK0.38508907
133MAP3K10.36854346
134ZAK0.36413697
135FGR0.36054658
136PRKAA20.35425546
137RPS6KA10.33839100
138FGFR30.33415558
139MAPK10.33297462
140ABL10.31794637
141HIPK20.30202595
142VRK10.29902136
143BMPR20.29514233
144MAPK40.29053520
145PTK20.27931441
146INSR0.27207509
147STK390.27112463
148LATS20.26980868

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045202.56889880
2ECM-receptor interaction_Homo sapiens_hsa045122.54933257
3Other glycan degradation_Homo sapiens_hsa005112.48072523
4Linoleic acid metabolism_Homo sapiens_hsa005912.42505750
5Ribosome_Homo sapiens_hsa030102.35170293
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.21440029
7Arachidonic acid metabolism_Homo sapiens_hsa005902.18252065
8Sphingolipid metabolism_Homo sapiens_hsa006002.13969354
9Mineral absorption_Homo sapiens_hsa049782.01748644
10Tight junction_Homo sapiens_hsa045301.96748974
11TGF-beta signaling pathway_Homo sapiens_hsa043501.73267841
12Sulfur metabolism_Homo sapiens_hsa009201.68511163
13Asthma_Homo sapiens_hsa053101.66719304
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.65036048
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.64441648
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61305369
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.60329833
18Hippo signaling pathway_Homo sapiens_hsa043901.60244601
19Basal cell carcinoma_Homo sapiens_hsa052171.58883069
20Tuberculosis_Homo sapiens_hsa051521.57249223
21Ether lipid metabolism_Homo sapiens_hsa005651.57206549
22Protein digestion and absorption_Homo sapiens_hsa049741.56306475
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55096406
24Influenza A_Homo sapiens_hsa051641.46274128
25Allograft rejection_Homo sapiens_hsa053301.42532905
26Amoebiasis_Homo sapiens_hsa051461.40849999
27B cell receptor signaling pathway_Homo sapiens_hsa046621.39067007
28Legionellosis_Homo sapiens_hsa051341.35953316
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34627667
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33789631
31Chemical carcinogenesis_Homo sapiens_hsa052041.31984752
32Focal adhesion_Homo sapiens_hsa045101.31187130
33* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30843932
34Bladder cancer_Homo sapiens_hsa052191.29090968
35Autoimmune thyroid disease_Homo sapiens_hsa053201.27827034
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.25780384
37Retinol metabolism_Homo sapiens_hsa008301.24608311
38Vitamin digestion and absorption_Homo sapiens_hsa049771.21208275
39Malaria_Homo sapiens_hsa051441.20799826
40Toxoplasmosis_Homo sapiens_hsa051451.20569997
41Small cell lung cancer_Homo sapiens_hsa052221.19683918
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18976191
43Proteoglycans in cancer_Homo sapiens_hsa052051.18686412
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15751482
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12316117
46Graft-versus-host disease_Homo sapiens_hsa053321.11731673
47Hedgehog signaling pathway_Homo sapiens_hsa043401.11662395
48Fat digestion and absorption_Homo sapiens_hsa049751.09734922
49Lysosome_Homo sapiens_hsa041421.09407110
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08079457
51MicroRNAs in cancer_Homo sapiens_hsa052061.05429179
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.03352733
53TNF signaling pathway_Homo sapiens_hsa046681.02470761
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01677540
55Viral myocarditis_Homo sapiens_hsa054161.00109578
56Leishmaniasis_Homo sapiens_hsa051400.99804402
57Notch signaling pathway_Homo sapiens_hsa043300.99271561
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98320389
59Pathways in cancer_Homo sapiens_hsa052000.97785123
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96174367
61p53 signaling pathway_Homo sapiens_hsa041150.91690573
62Wnt signaling pathway_Homo sapiens_hsa043100.91404065
63Salmonella infection_Homo sapiens_hsa051320.91193246
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.90922894
65Axon guidance_Homo sapiens_hsa043600.89763557
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88947512
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87750584
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87366403
69Prostate cancer_Homo sapiens_hsa052150.85873986
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85499832
71Osteoclast differentiation_Homo sapiens_hsa043800.84994026
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84916323
73Renal cell carcinoma_Homo sapiens_hsa052110.84661697
74Phagosome_Homo sapiens_hsa041450.84429572
75Antigen processing and presentation_Homo sapiens_hsa046120.83774964
76Hepatitis B_Homo sapiens_hsa051610.82735990
77Chemokine signaling pathway_Homo sapiens_hsa040620.82388069
78Insulin resistance_Homo sapiens_hsa049310.81968373
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81833504
80Rap1 signaling pathway_Homo sapiens_hsa040150.81816098
81Histidine metabolism_Homo sapiens_hsa003400.81291859
82Herpes simplex infection_Homo sapiens_hsa051680.81260753
83Pertussis_Homo sapiens_hsa051330.81071420
84Ras signaling pathway_Homo sapiens_hsa040140.80287942
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.80077903
86Glutathione metabolism_Homo sapiens_hsa004800.79845913
87Type I diabetes mellitus_Homo sapiens_hsa049400.79549288
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.78796850
89Chronic myeloid leukemia_Homo sapiens_hsa052200.78165099
90Hematopoietic cell lineage_Homo sapiens_hsa046400.78022279
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.77858330
92African trypanosomiasis_Homo sapiens_hsa051430.77855163
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77852487
94Galactose metabolism_Homo sapiens_hsa000520.73033744
95Ovarian steroidogenesis_Homo sapiens_hsa049130.72588446
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.72376557
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71120058
98PPAR signaling pathway_Homo sapiens_hsa033200.70183736
99Renin-angiotensin system_Homo sapiens_hsa046140.69978109
100T cell receptor signaling pathway_Homo sapiens_hsa046600.69802879
101Dorso-ventral axis formation_Homo sapiens_hsa043200.69499716
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69186903
103Hepatitis C_Homo sapiens_hsa051600.68659877
104Rheumatoid arthritis_Homo sapiens_hsa053230.67504604
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.67345166
106Shigellosis_Homo sapiens_hsa051310.67176855
107Platelet activation_Homo sapiens_hsa046110.66994014
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.65429158
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.64949849
110Pancreatic secretion_Homo sapiens_hsa049720.64786853
111FoxO signaling pathway_Homo sapiens_hsa040680.64575308
112Melanogenesis_Homo sapiens_hsa049160.64187409
113Measles_Homo sapiens_hsa051620.64064600
114Complement and coagulation cascades_Homo sapiens_hsa046100.63616198
115ABC transporters_Homo sapiens_hsa020100.61790675
116Apoptosis_Homo sapiens_hsa042100.61627046
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60470286
118Melanoma_Homo sapiens_hsa052180.60423497
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59560507
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.58891030
121HIF-1 signaling pathway_Homo sapiens_hsa040660.58670442
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.58547368
123Thyroid cancer_Homo sapiens_hsa052160.58393351
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57942215
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.56918962
126HTLV-I infection_Homo sapiens_hsa051660.56632761
127VEGF signaling pathway_Homo sapiens_hsa043700.55997789
128Pancreatic cancer_Homo sapiens_hsa052120.55534192
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55435147
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55160748
131Endocytosis_Homo sapiens_hsa041440.55020151
132Renin secretion_Homo sapiens_hsa049240.54438239
133Staphylococcus aureus infection_Homo sapiens_hsa051500.53433121
134Estrogen signaling pathway_Homo sapiens_hsa049150.52934079
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51300992
136Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50781702
137Prolactin signaling pathway_Homo sapiens_hsa049170.50346200
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49431810
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48778915
140Acute myeloid leukemia_Homo sapiens_hsa052210.46967847
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43999714
142Choline metabolism in cancer_Homo sapiens_hsa052310.43307280
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42890756
144MAPK signaling pathway_Homo sapiens_hsa040100.42586368
145GnRH signaling pathway_Homo sapiens_hsa049120.41976427

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