KLF14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cartilage development involved in endochondral bone morphogenesis (GO:0060351)8.26056572
2chondrocyte development (GO:0002063)8.01370959
3leukotriene biosynthetic process (GO:0019370)7.51222825
4negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)7.22485952
5cell aggregation (GO:0098743)6.56220131
6cartilage condensation (GO:0001502)6.56220131
7notochord development (GO:0030903)6.28778098
8diterpenoid biosynthetic process (GO:0016102)6.08541079
9ribosomal small subunit biogenesis (GO:0042274)6.05623893
10positive regulation of glomerulus development (GO:0090193)5.83148978
11positive regulation of male gonad development (GO:2000020)5.62818698
12limb bud formation (GO:0060174)5.44936164
13embryonic skeletal joint morphogenesis (GO:0060272)5.42796603
14regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.33417417
15cell proliferation involved in kidney development (GO:0072111)5.28432501
16regulation of male gonad development (GO:2000018)5.19547125
17bundle of His cell to Purkinje myocyte communication (GO:0086069)5.13680658
18viral transcription (GO:0019083)5.11736698
19neural crest cell development (GO:0014032)5.11467963
20keratan sulfate catabolic process (GO:0042340)5.11231274
21collagen fibril organization (GO:0030199)5.01150745
22regulation of glomerulus development (GO:0090192)4.97084280
23cell proliferation involved in metanephros development (GO:0072203)4.94852301
24leukotriene metabolic process (GO:0006691)4.85243828
25muscle cell fate commitment (GO:0042693)4.80710797
26endocardial cushion morphogenesis (GO:0003203)4.75804456
27translational termination (GO:0006415)4.74353333
28outer ear morphogenesis (GO:0042473)4.65462623
29tooth mineralization (GO:0034505)4.52130172
30terpenoid biosynthetic process (GO:0016114)4.49340976
31positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)4.44466344
32fatty acid derivative biosynthetic process (GO:1901570)4.44191225
33icosanoid biosynthetic process (GO:0046456)4.44191225
34mesenchyme morphogenesis (GO:0072132)4.43421442
35positive regulation of chondrocyte differentiation (GO:0032332)4.33938250
36lymph vessel development (GO:0001945)4.28178380
37endothelium development (GO:0003158)4.26312752
38endothelial cell morphogenesis (GO:0001886)4.22943844
39short-term memory (GO:0007614)4.13979649
40mesenchymal cell development (GO:0014031)4.11626112
41midgut development (GO:0007494)4.10851624
42positive regulation of mesonephros development (GO:0061213)4.09122173
43vitamin A metabolic process (GO:0006776)4.08915762
44translational elongation (GO:0006414)4.04728103
45appendage development (GO:0048736)3.92581874
46limb development (GO:0060173)3.92581874
47unsaturated fatty acid biosynthetic process (GO:0006636)3.90184923
48negative regulation of smooth muscle cell differentiation (GO:0051151)3.87470001
49maturation of SSU-rRNA (GO:0030490)3.86179523
50ventricular cardiac muscle cell development (GO:0055015)3.85791693
51cochlea morphogenesis (GO:0090103)3.82293096
52cell differentiation involved in metanephros development (GO:0072202)3.80399485
53glutathione metabolic process (GO:0006749)3.79881988
54SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.79195905
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.76751437
56glomerulus development (GO:0032835)3.76730253
57negative regulation of homotypic cell-cell adhesion (GO:0034111)3.73355061
58cartilage development (GO:0051216)3.73199586
59G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.72071114
60cardiac epithelial to mesenchymal transition (GO:0060317)3.71624950
61outflow tract septum morphogenesis (GO:0003148)3.71408522
62positive regulation of cartilage development (GO:0061036)3.70797113
63protein retention in ER lumen (GO:0006621)3.70515517
64mitochondrial calcium ion transport (GO:0006851)3.67831823
65cotranslational protein targeting to membrane (GO:0006613)3.66827238
66regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.65889888
67regulation of mammary gland epithelial cell proliferation (GO:0033599)3.65813702
68response to BMP (GO:0071772)3.65185182
69cellular response to BMP stimulus (GO:0071773)3.65185182
70protein targeting to ER (GO:0045047)3.64777006
71cellular protein complex disassembly (GO:0043624)3.62203733
72viral life cycle (GO:0019058)3.57542929
73proximal/distal pattern formation (GO:0009954)3.55259619
74collagen catabolic process (GO:0030574)3.53667450
75collagen metabolic process (GO:0032963)3.52069297
76blood vessel maturation (GO:0001955)3.48866640
77establishment of protein localization to endoplasmic reticulum (GO:0072599)3.46819670
78regulation of mesonephros development (GO:0061217)3.45629959
79positive regulation of metanephros development (GO:0072216)3.43954162
80protein localization to endoplasmic reticulum (GO:0070972)3.39088602
81heart valve formation (GO:0003188)3.37989658
82negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.37091758
83deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.36993079
84protein heterotrimerization (GO:0070208)3.36706244
85stem cell development (GO:0048864)3.36236982
86translational initiation (GO:0006413)3.35836628
87mesenchymal cell proliferation (GO:0010463)3.31539037
88positive regulation of stem cell differentiation (GO:2000738)3.31514212
89body morphogenesis (GO:0010171)3.31019160
90bone trabecula formation (GO:0060346)3.30406961
91face development (GO:0060324)3.29715410
92maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.29673280
93proteoglycan metabolic process (GO:0006029)3.26805520
94multicellular organismal macromolecule metabolic process (GO:0044259)3.25006074
95positive regulation of extracellular matrix organization (GO:1903055)3.22500132
96regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.19259874
97positive regulation of kidney development (GO:0090184)3.17780181
98protein complex disassembly (GO:0043241)3.17748216
99multicellular organismal catabolic process (GO:0044243)3.17294264
100heart trabecula formation (GO:0060347)3.17120595
101negative regulation of chondrocyte differentiation (GO:0032331)3.16705669
102negative regulation of cartilage development (GO:0061037)3.15778698
103middle ear morphogenesis (GO:0042474)3.15646307
104regulation of smooth muscle cell differentiation (GO:0051150)3.15627632
105negative regulation of fatty acid transport (GO:2000192)3.15003932
106chondrocyte differentiation (GO:0002062)3.14202270
107mitochondrial fusion (GO:0008053)3.14095523
108positive regulation of myotube differentiation (GO:0010831)3.12890076
109regulation of mesenchymal cell apoptotic process (GO:2001053)3.12558837
110embryonic digestive tract development (GO:0048566)3.12253974
111multicellular organismal metabolic process (GO:0044236)3.10072525
112basement membrane organization (GO:0071711)3.08181166
113epithelial to mesenchymal transition (GO:0001837)3.07898137
114chondroitin sulfate biosynthetic process (GO:0030206)3.07665975
115peptidyl-proline hydroxylation (GO:0019511)3.05887935
116regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.05084893
117regulation of heart morphogenesis (GO:2000826)3.04230307
118positive regulation of nitric-oxide synthase activity (GO:0051000)3.02804446
119heart valve morphogenesis (GO:0003179)3.02269481
120negative regulation of keratinocyte proliferation (GO:0010839)3.02013151
121regulation of chondrocyte differentiation (GO:0032330)2.99909746
122negative regulation of myoblast differentiation (GO:0045662)2.98089286
123insulin-like growth factor receptor signaling pathway (GO:0048009)2.97988657
124negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.97394778
125lung vasculature development (GO:0060426)2.97066988
126heart morphogenesis (GO:0003007)2.97001833
127gonadal mesoderm development (GO:0007506)2.96784283
128extracellular negative regulation of signal transduction (GO:1900116)2.96440253
129extracellular regulation of signal transduction (GO:1900115)2.96440253
130embryonic camera-type eye development (GO:0031076)2.95202058
131nephron tubule morphogenesis (GO:0072078)2.95142072
132nephron epithelium morphogenesis (GO:0072088)2.95142072
133branching involved in ureteric bud morphogenesis (GO:0001658)2.94166817
134skeletal system development (GO:0001501)2.93733166
135negative regulation of systemic arterial blood pressure (GO:0003085)2.93255836
136negative regulation of norepinephrine secretion (GO:0010700)2.92705053
137forelimb morphogenesis (GO:0035136)2.92513891
138oxidative phosphorylation (GO:0006119)2.90077372
139macromolecular complex disassembly (GO:0032984)2.89990234
140mitotic chromosome condensation (GO:0007076)2.89921500
141protein targeting to membrane (GO:0006612)2.88450862
142protein localization to chromosome, centromeric region (GO:0071459)2.87243970
143embryonic forelimb morphogenesis (GO:0035115)2.86496161
144ribonucleoprotein complex biogenesis (GO:0022613)2.84135437
145keratan sulfate biosynthetic process (GO:0018146)2.81243928
146retinal metabolic process (GO:0042574)2.78538055
147positive regulation of epithelial to mesenchymal transition (GO:0010718)2.77826663
148low-density lipoprotein particle clearance (GO:0034383)2.77327917
149histone phosphorylation (GO:0016572)2.76774988
150regulation of cartilage development (GO:0061035)2.76583472
151proline biosynthetic process (GO:0006561)2.70404366
152negative regulation of skeletal muscle tissue development (GO:0048642)2.70321788
153pattern specification involved in kidney development (GO:0061004)2.68862165
154detection of molecule of bacterial origin (GO:0032490)2.66834779
155amyloid precursor protein catabolic process (GO:0042987)2.64360526
156regulation of spindle organization (GO:0090224)2.64338952
157mitotic G1 DNA damage checkpoint (GO:0031571)2.63972873
158regulation of early endosome to late endosome transport (GO:2000641)2.63026002
159embryonic viscerocranium morphogenesis (GO:0048703)2.62339358
160cellular protein complex localization (GO:0034629)2.62142565
161mitochondrion distribution (GO:0048311)2.61219385
162GDP-mannose metabolic process (GO:0019673)2.60956498
163positive regulation of odontogenesis (GO:0042482)2.57903285
164trabecula formation (GO:0060343)2.56485971
165skin morphogenesis (GO:0043589)2.56458536
166peptide catabolic process (GO:0043171)2.55627480
167cysteine metabolic process (GO:0006534)2.53949457
168atrial septum morphogenesis (GO:0060413)2.53910139
169regulation of secondary heart field cardioblast proliferation (GO:0003266)2.53615982
170regulation of cardioblast proliferation (GO:0003264)2.53615982
171regulation of mitotic spindle organization (GO:0060236)2.53114991
172formation of translation preinitiation complex (GO:0001731)2.52802779
173membrane protein ectodomain proteolysis (GO:0006509)2.52473690
174mammary gland epithelial cell differentiation (GO:0060644)2.51394493
175peptidyl-histidine modification (GO:0018202)2.51018209
176cell-substrate adherens junction assembly (GO:0007045)2.48971069
177focal adhesion assembly (GO:0048041)2.48971069
178regulation of sequestering of triglyceride (GO:0010889)2.46988127
179protein localization to kinetochore (GO:0034501)2.45381868
180mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.44694239
181telomere maintenance via semi-conservative replication (GO:0032201)2.43573755
182positive regulation of DNA-dependent DNA replication (GO:2000105)2.42679844
183nuclear envelope reassembly (GO:0031468)2.42349455
184mitotic nuclear envelope reassembly (GO:0007084)2.42349455
185mRNA catabolic process (GO:0006402)2.42215889
186cell migration involved in heart development (GO:0060973)2.39402413
187regulation of apoptotic process involved in morphogenesis (GO:1902337)2.38645508
188nuclear-transcribed mRNA catabolic process (GO:0000956)2.38563189
189kidney mesenchyme development (GO:0072074)2.37652575
190pentose metabolic process (GO:0019321)2.35545170
191ATP synthesis coupled proton transport (GO:0015986)2.35328872
192energy coupled proton transport, down electrochemical gradient (GO:0015985)2.35328872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.24796153
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.83781704
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.28929417
4AR_21572438_ChIP-Seq_LNCaP_Human3.68069145
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.54982539
6EED_16625203_ChIP-ChIP_MESCs_Mouse3.20618190
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.99010135
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.96256857
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.93990558
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.84354396
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.82219674
12PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.79847844
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.78483922
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.76695827
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.65548487
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.55215518
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.52998005
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.45822314
19FUS_26573619_Chip-Seq_HEK293_Human2.42899387
20* EZH2_27304074_Chip-Seq_ESCs_Mouse2.42198757
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.36123852
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.33889756
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.33559287
24XRN2_22483619_ChIP-Seq_HELA_Human2.33007196
25POU5F1_16153702_ChIP-ChIP_HESCs_Human2.32506339
26VDR_21846776_ChIP-Seq_THP-1_Human2.30229047
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29824432
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29583367
29EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28435004
30RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28435004
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26379076
32LXR_22292898_ChIP-Seq_THP-1_Human2.24843719
33CBX2_27304074_Chip-Seq_ESCs_Mouse2.21657430
34MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20165472
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14578990
36TRIM28_17542650_ChIP-ChIP_NTERA2_Human2.13714324
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.12786908
38ELK3_25401928_ChIP-Seq_HUVEC_Human2.06466712
39* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01584162
40* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01575897
41GATA1_22025678_ChIP-Seq_K562_Human2.00358476
42RACK7_27058665_Chip-Seq_MCF-7_Human2.00260192
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00219312
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.98969352
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98092872
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.96462964
47* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96347746
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.92853565
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.84703545
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.84329364
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.81106595
52ZNF263_19887448_ChIP-Seq_K562_Human1.80212600
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79988400
54TP53_18474530_ChIP-ChIP_U2OS_Human1.77181756
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76722169
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.74960759
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.74425530
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71045675
59TTF2_22483619_ChIP-Seq_HELA_Human1.69369512
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.68893971
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68741358
62CJUN_26792858_Chip-Seq_BT549_Human1.68569991
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68203882
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.64943439
65P300_19829295_ChIP-Seq_ESCs_Human1.64936333
66SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.62688884
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.62209968
68ISL1_27105846_Chip-Seq_CPCs_Mouse1.59914247
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.55832899
70FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55186054
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53708858
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.53281136
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53021151
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52984906
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.52845666
76RXR_22108803_ChIP-Seq_LS180_Human1.52698598
77DCP1A_22483619_ChIP-Seq_HELA_Human1.52574237
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.52000277
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50556249
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50032192
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47298736
82EWS_26573619_Chip-Seq_HEK293_Human1.46820586
83CTCF_18555785_ChIP-Seq_MESCs_Mouse1.45753612
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45352271
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44672350
86TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44498281
87CTCF_26484167_Chip-Seq_Bcells_Mouse1.43204872
88P68_20966046_ChIP-Seq_HELA_Human1.43204721
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42782402
90NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42619379
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41530216
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39866721
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37985711
94MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37658990
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.37495136
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.37322609
97TFEB_21752829_ChIP-Seq_HELA_Human1.36335629
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35858543
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34820637
100* RNF2_27304074_Chip-Seq_NSC_Mouse1.33246566
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32562444
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31231908
103ESR1_20079471_ChIP-ChIP_T-47D_Human1.30652625
104CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28690000
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27124748
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26602301
107KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26440646
108BRD4_25478319_ChIP-Seq_HGPS_Human1.25984811
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25395243
110MYC_22102868_ChIP-Seq_BL_Human1.24990437
111NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24883260
112CTCF_21964334_Chip-Seq_Bcells_Human1.24813961
113E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23986031
114ATF3_27146783_Chip-Seq_COLON_Human1.23967557
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23882965
116KDM2B_26808549_Chip-Seq_DND41_Human1.22614641
117* KDM2B_26808549_Chip-Seq_K562_Human1.20747836
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20444487
119* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20310387
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20256647
121STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19671434
122P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18117425
123IGF1R_20145208_ChIP-Seq_DFB_Human1.17954135
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17693153
125* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16601318
126TP63_17297297_ChIP-ChIP_HaCaT_Human1.16397057
127EZH2_27294783_Chip-Seq_ESCs_Mouse1.15355966
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14591334
129RING1B_27294783_Chip-Seq_NPCs_Mouse1.14090802
130ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13940831
131* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13800468
132* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13130579
133GBX2_23144817_ChIP-Seq_PC3_Human1.13031246
134SMC3_22415368_ChIP-Seq_MEFs_Mouse1.11200562
135CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10357964
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10232759
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09918861
138P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09368048
139TP53_20018659_ChIP-ChIP_R1E_Mouse1.07446016
140TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07124904
141PIAS1_25552417_ChIP-Seq_VCAP_Human1.06017159
142SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05823424
143TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.05174333
144NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04536978
145BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04112550
146CLOCK_20551151_ChIP-Seq_293T_Human1.04080915
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03595502
148ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02680259
149SA1_22415368_ChIP-Seq_MEFs_Mouse1.02668334
150SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02224491
151ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01637809
152NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01596259
153* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01248323
154SMAD4_21799915_ChIP-Seq_A2780_Human1.01206039
155GABP_19822575_ChIP-Seq_HepG2_Human1.00930055
156MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00899578
157ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00849568
158RING1B_27294783_Chip-Seq_ESCs_Mouse1.00808146
159STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.00792461
160KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00628015
161KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00628015
162KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00628015
163VDR_22108803_ChIP-Seq_LS180_Human1.00286323
164E2F7_22180533_ChIP-Seq_HELA_Human1.00220742
165RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99938720
166GATA2_21666600_ChIP-Seq_HMVEC_Human0.99811821
167MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99799661
168CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99590235
169VDR_24787735_ChIP-Seq_THP-1_Human0.99476874
170FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99209714
171TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99081715
172SOX2_20726797_ChIP-Seq_SW620_Human0.98072432
173SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96834341
174ELF1_20517297_ChIP-Seq_JURKAT_Human0.96371958
175FOXP1_21924763_ChIP-Seq_HESCs_Human0.95167265
176PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94321715
177MAF_26560356_Chip-Seq_TH2_Human0.93285412
178SA1_27219007_Chip-Seq_Bcells_Human0.93076509
179TAF15_26573619_Chip-Seq_HEK293_Human0.92890633
180YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92807488
181FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91997050
182ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91957697
183NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91100615
184AR_21909140_ChIP-Seq_LNCAP_Human0.89756522
185NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89152040
186NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89152040
187BP1_19119308_ChIP-ChIP_Hs578T_Human0.88473476
188* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88259869
189TCF4_18268006_ChIP-ChIP_LS174T_Human0.87484339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting6.06592110
2MP0002282_abnormal_trachea_morphology4.85009617
3MP0003123_paternal_imprinting4.34463912
4MP0004134_abnormal_chest_morphology3.78639920
5MP0003121_genomic_imprinting3.64014437
6MP0005503_abnormal_tendon_morphology3.57868658
7MP0003385_abnormal_body_wall3.02929130
8MP0004272_abnormal_basement_membrane2.93736053
9MP0002249_abnormal_larynx_morphology2.89468846
10MP0000678_abnormal_parathyroid_gland2.88054094
11MP0003942_abnormal_urinary_system2.52102280
12MP0000003_abnormal_adipose_tissue2.52051380
13MP0000163_abnormal_cartilage_morphology2.43855286
14MP0000733_abnormal_muscle_development2.40939790
15MP0009250_abnormal_appendicular_skeleto2.32309744
16MP0001879_abnormal_lymphatic_vessel2.28513959
17MP0010030_abnormal_orbit_morphology2.26318114
18MP0002933_joint_inflammation2.23730402
19MP0005670_abnormal_white_adipose2.16481806
20MP0000759_abnormal_skeletal_muscle2.12794276
21MP0005375_adipose_tissue_phenotype2.04867581
22MP0005058_abnormal_lysosome_morphology2.03570347
23MP0009384_cardiac_valve_regurgitation2.02938899
24MP0005451_abnormal_body_composition1.95427459
25MP0005257_abnormal_intraocular_pressure1.92443000
26MP0004185_abnormal_adipocyte_glucose1.92084104
27MP0000013_abnormal_adipose_tissue1.90078808
28MP0001188_hyperpigmentation1.88605358
29MP0002115_abnormal_skeleton_extremities1.88207058
30MP0005408_hypopigmentation1.84967197
31MP0003755_abnormal_palate_morphology1.84886254
32MP0010368_abnormal_lymphatic_system1.84540483
33MP0005666_abnormal_adipose_tissue1.80759697
34MP0009053_abnormal_anal_canal1.78945045
35MP0002234_abnormal_pharynx_morphology1.77384588
36MP0004233_abnormal_muscle_weight1.77181440
37MP0005248_abnormal_Harderian_gland1.76174120
38MP0003279_aneurysm1.73099784
39MP0000762_abnormal_tongue_morphology1.71199878
40MP0001270_distended_abdomen1.70788287
41MP0000049_abnormal_middle_ear1.70091639
42MP0002109_abnormal_limb_morphology1.69724630
43MP0005508_abnormal_skeleton_morphology1.68533264
44MP0004858_abnormal_nervous_system1.68506235
45MP0003119_abnormal_digestive_system1.64177784
46MP0002113_abnormal_skeleton_development1.62598898
47MP0000750_abnormal_muscle_regeneration1.62343826
48MP0003693_abnormal_embryo_hatching1.60529325
49MP0000858_altered_metastatic_potential1.59506448
50MP0004484_altered_response_of1.56591816
51MP0003937_abnormal_limbs/digits/tail_de1.52864567
52MP0000534_abnormal_ureter_morphology1.48581795
53MP0002822_catalepsy1.46979749
54MP0004130_abnormal_muscle_cell1.46929670
55MP0001958_emphysema1.45069625
56MP0006138_congestive_heart_failure1.43600895
57MP0002116_abnormal_craniofacial_bone1.42031328
58MP0000537_abnormal_urethra_morphology1.41607874
59MP0003935_abnormal_craniofacial_develop1.39988238
60MP0004197_abnormal_fetal_growth/weight/1.38087672
61MP0008932_abnormal_embryonic_tissue1.36799080
62MP0003959_abnormal_lean_body1.35737486
63MP0008438_abnormal_cutaneous_collagen1.35111048
64MP0004087_abnormal_muscle_fiber1.34485729
65MP0002111_abnormal_tail_morphology1.34155985
66MP0001299_abnormal_eye_distance/1.33104916
67MP0005367_renal/urinary_system_phenotyp1.32309742
68MP0000516_abnormal_urinary_system1.32309742
69MP0002896_abnormal_bone_mineralization1.27367261
70MP0002233_abnormal_nose_morphology1.26766835
71MP0002163_abnormal_gland_morphology1.26632809
72MP0000767_abnormal_smooth_muscle1.26198462
73MP0000747_muscle_weakness1.19024632
74MP0002114_abnormal_axial_skeleton1.17448708
75MP0003646_muscle_fatigue1.16945850
76MP0003787_abnormal_imprinting1.16887899
77MP0005369_muscle_phenotype1.15516889
78MP0001849_ear_inflammation1.14993259
79MP0002938_white_spotting1.13022398
80MP0002060_abnormal_skin_morphology1.12152127
81MP0003941_abnormal_skin_development1.12110467
82MP0002932_abnormal_joint_morphology1.11763785
83MP0004036_abnormal_muscle_relaxation1.11229158
84MP0002971_abnormal_brown_adipose1.10759688
85MP0005076_abnormal_cell_differentiation1.10321526
86MP0000566_synostosis1.06842404
87MP0005409_darkened_coat_color1.06499482
88MP0000432_abnormal_head_morphology1.05793373
89MP0008260_abnormal_autophagy1.05715303
90MP0005390_skeleton_phenotype1.05155703
91MP0005623_abnormal_meninges_morphology1.04929274
92MP0001286_abnormal_eye_development1.03754024
93MP0004381_abnormal_hair_follicle1.03568739
94MP0003077_abnormal_cell_cycle1.02056384
95MP0003938_abnormal_ear_development1.01699137
96MP0000681_abnormal_thyroid_gland1.01628109
97MP0005501_abnormal_skin_physiology0.99576257
98MP0003115_abnormal_respiratory_system0.99366674
99MP0005330_cardiomyopathy0.98412548
100MP0003567_abnormal_fetal_cardiomyocyte0.98383834
101MP0002108_abnormal_muscle_morphology0.97942313
102MP0000350_abnormal_cell_proliferation0.97406026
103MP0001177_atelectasis0.96908317
104MP0003705_abnormal_hypodermis_morpholog0.96660660
105MP0002106_abnormal_muscle_physiology0.96140544
106MP0005171_absent_coat_pigmentation0.93902898
107MP0003111_abnormal_nucleus_morphology0.93323287
108MP0000613_abnormal_salivary_gland0.90768568
109MP0001661_extended_life_span0.89711214
110MP0009780_abnormal_chondrocyte_physiolo0.88785751
111MP0002970_abnormal_white_adipose0.88400378
112MP0001346_abnormal_lacrimal_gland0.88350067
113MP0003091_abnormal_cell_migration0.87355904
114MP0004957_abnormal_blastocyst_morpholog0.87161399
115MP0002909_abnormal_adrenal_gland0.86514423
116MP0005379_endocrine/exocrine_gland_phen0.86337625
117MP0002269_muscular_atrophy0.84884014
118MP0009115_abnormal_fat_cell0.83615520
119MP0000751_myopathy0.83548873
120MP0002295_abnormal_pulmonary_circulatio0.83297479
121MP0001542_abnormal_bone_strength0.82722884
122MP0000015_abnormal_ear_pigmentation0.82354212
123MP0005167_abnormal_blood-brain_barrier0.80900790
124MP0002089_abnormal_postnatal_growth/wei0.80669444
125MP0009379_abnormal_foot_pigmentation0.80573731
126MP0008058_abnormal_DNA_repair0.79609712
127MP0002877_abnormal_melanocyte_morpholog0.78998849
128MP0001186_pigmentation_phenotype0.78705288
129MP0002736_abnormal_nociception_after0.77711957
130MP0002925_abnormal_cardiovascular_devel0.77606338
131MP0009697_abnormal_copulation0.77515649
132MP0003795_abnormal_bone_structure0.77214188
133MP0003828_pulmonary_edema0.77125618
134MP0001243_abnormal_dermal_layer0.76853252
135MP0004085_abnormal_heartbeat0.76788065
136MP0003315_abnormal_perineum_morphology0.76542136
137MP0002128_abnormal_blood_circulation0.76506634
138MP0003786_premature_aging0.74304303
139MP0000428_abnormal_craniofacial_morphol0.74288341
140MP0005023_abnormal_wound_healing0.74217048
141MP0005646_abnormal_pituitary_gland0.73804791
142MP0002697_abnormal_eye_size0.73689252
143MP0010630_abnormal_cardiac_muscle0.73027164
144MP0003186_abnormal_redox_activity0.72901074
145MP0003453_abnormal_keratinocyte_physiol0.68376346
146MP0002796_impaired_skin_barrier0.68126345
147MP0000371_diluted_coat_color0.66907780
148MP0002075_abnormal_coat/hair_pigmentati0.66699694
149MP0006292_abnormal_olfactory_placode0.66624329
150MP0002081_perinatal_lethality0.66623850
151MP0008007_abnormal_cellular_replicative0.65475121
152MP0005275_abnormal_skin_tensile0.64557451
153MP0002876_abnormal_thyroid_physiology0.63094770
154MP0001544_abnormal_cardiovascular_syste0.63036666
155MP0005385_cardiovascular_system_phenoty0.63036666
156MP0000266_abnormal_heart_morphology0.61800425
157MP0000749_muscle_degeneration0.61637654
158MP0000343_altered_response_to0.61523564
159MP0001614_abnormal_blood_vessel0.61260774
160MP0002972_abnormal_cardiac_muscle0.61120428
161MP0008004_abnormal_stomach_pH0.60485371
162MP0009703_decreased_birth_body0.59807224
163MP0000026_abnormal_inner_ear0.55925421

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)9.90323622
2Vitreoretinal degeneration (HP:0000655)9.58241123
3Irregular epiphyses (HP:0010582)9.30198415
4Hypoplastic ischia (HP:0003175)6.04008775
5Small epiphyses (HP:0010585)5.77984488
6Abnormality of the ischium (HP:0003174)5.35258241
7Mild short stature (HP:0003502)4.96002077
8Type 1 muscle fiber predominance (HP:0003803)4.76320273
9Flattened epiphyses (HP:0003071)4.74950577
10Protrusio acetabuli (HP:0003179)4.73843888
11Flat capital femoral epiphysis (HP:0003370)4.56563232
12Cupped ribs (HP:0000887)4.54356164
13Delayed epiphyseal ossification (HP:0002663)4.48026951
14Genu varum (HP:0002970)4.45572066
15Premature rupture of membranes (HP:0001788)4.43805108
16Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.26872118
17Neonatal short-limb short stature (HP:0008921)3.92589925
18Fibular hypoplasia (HP:0003038)3.86647515
19Arthropathy (HP:0003040)3.85150264
20Osteoarthritis (HP:0002758)3.76945343
21Increased variability in muscle fiber diameter (HP:0003557)3.76628769
22Ankle contracture (HP:0006466)3.68866213
23Bulbar palsy (HP:0001283)3.56634823
24Abnormality of skeletal muscle fiber size (HP:0012084)3.56346271
25Spinal rigidity (HP:0003306)3.54409206
26Abnormal tarsal ossification (HP:0008369)3.51129250
27Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.50056342
28Hepatoblastoma (HP:0002884)3.49590074
29Vertebral compression fractures (HP:0002953)3.46461037
30Calcaneovalgus deformity (HP:0001848)3.43044364
31Muscle fiber inclusion bodies (HP:0100299)3.42869248
32Abnormality of femoral epiphyses (HP:0006499)3.32821053
33Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.32821053
34Trismus (HP:0000211)3.23580896
35Absent epiphyses (HP:0010577)3.22935543
36Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.22935543
37Abnormality of the phalanges of the 2nd finger (HP:0009541)3.21264118
38Nemaline bodies (HP:0003798)3.20831511
39Generalized amyotrophy (HP:0003700)3.19818593
40Deformed tarsal bones (HP:0008119)3.12434411
41Reduced subcutaneous adipose tissue (HP:0003758)3.09060210
42Increased connective tissue (HP:0009025)3.09055439
43Absent frontal sinuses (HP:0002688)3.02274514
44Diastasis recti (HP:0001540)3.00848835
45Abnormality of incisor morphology (HP:0011063)2.97613529
46Achilles tendon contracture (HP:0001771)2.94934484
47Cervical subluxation (HP:0003308)2.93913743
48Flat acetabular roof (HP:0003180)2.89059456
49Mildly elevated creatine phosphokinase (HP:0008180)2.86958043
50Mesomelia (HP:0003027)2.79804669
51Myopathic facies (HP:0002058)2.77039429
52Abnormality of the epiphysis of the femoral head (HP:0010574)2.77022031
53Broad phalanx (HP:0006009)2.75970295
54Abnormality of the vertebral endplates (HP:0005106)2.75899644
55Progressive muscle weakness (HP:0003323)2.75839472
56Thin ribs (HP:0000883)2.75122127
57Abnormality of the distal phalanges of the toes (HP:0010182)2.74844342
58Abnormality of the femoral head (HP:0003368)2.74287603
59Elbow flexion contracture (HP:0002987)2.73312262
60Distal arthrogryposis (HP:0005684)2.73080640
61Glossoptosis (HP:0000162)2.72697818
62Broad thumb (HP:0011304)2.70395275
63Exostoses (HP:0100777)2.64825692
64Ulnar deviation of the wrist (HP:0003049)2.63294982
65Abnormality of the vitreous humor (HP:0004327)2.63241853
66Unilateral renal agenesis (HP:0000122)2.63157152
67Abnormality of the proximal phalanges of the hand (HP:0009834)2.61489320
68Abnormality of glycolipid metabolism (HP:0010969)2.60415106
69Abnormality of liposaccharide metabolism (HP:0010968)2.60415106
70Abnormality of glycosphingolipid metabolism (HP:0004343)2.60415106
71Metaphyseal cupping (HP:0003021)2.59923132
72Protuberant abdomen (HP:0001538)2.59362056
73Broad long bones (HP:0005622)2.58405460
74Double outlet right ventricle (HP:0001719)2.57658672
75Congenital malformation of the right heart (HP:0011723)2.57658672
76Abnormality of the umbilical cord (HP:0010881)2.56352432
77Abnormality of the pubic bones (HP:0003172)2.54947648
78Abnormal foot bone ossification (HP:0010675)2.54071752
79Relative macrocephaly (HP:0004482)2.51598000
80Thoracolumbar scoliosis (HP:0002944)2.50340499
81Abnormality of carpal bone ossification (HP:0006257)2.48923101
82Long clavicles (HP:0000890)2.48409549
83Breast hypoplasia (HP:0003187)2.45448500
84Distal lower limb muscle weakness (HP:0009053)2.44735267
85Abnormality of the Achilles tendon (HP:0005109)2.44002604
86Barrel-shaped chest (HP:0001552)2.43415364
87Short femoral neck (HP:0100864)2.42145199
88Abnormality of the calcaneus (HP:0008364)2.40937938
89Distal lower limb amyotrophy (HP:0008944)2.40438480
90Platyspondyly (HP:0000926)2.39848073
91Irregular vertebral endplates (HP:0003301)2.39752408
92Severe Myopia (HP:0011003)2.39312403
93Ulnar bowing (HP:0003031)2.38781429
94Broad distal phalanx of finger (HP:0009836)2.38357435
95Shallow orbits (HP:0000586)2.37805187
96Stridor (HP:0010307)2.36163884
97Abnormality of the phalanges of the 5th finger (HP:0004213)2.35829301
98Morphological abnormality of the middle ear (HP:0008609)2.35823539
99Wide anterior fontanel (HP:0000260)2.34528969
100Aplasia/Hypoplasia of the fibula (HP:0006492)2.33670961
101Round ear (HP:0100830)2.33278579
102Limited hip movement (HP:0008800)2.31423248
103Metaphyseal dysplasia (HP:0100255)2.31247136
104Waddling gait (HP:0002515)2.28596949
105Broad phalanges of the hand (HP:0009768)2.28568539
106Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.27541453
107Micromelia (HP:0002983)2.26412511
108Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.25013966
109Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.24009163
110Dysostosis multiplex (HP:0000943)2.22984255
111Slender build (HP:0001533)2.22842186
112Fragile skin (HP:0001030)2.21169778
113Down-sloping shoulders (HP:0200021)2.20129484
114Metaphyseal irregularity (HP:0003025)2.19639773
115Hypoplasia of the odontoid process (HP:0003311)2.17269574
116Broad finger (HP:0001500)2.15209555
117Abnormal vertebral ossification (HP:0100569)2.14659230
118Soft skin (HP:0000977)2.13764968
119Enlarged epiphyses (HP:0010580)2.13657804
120Sprengel anomaly (HP:0000912)2.13100270
121Centrally nucleated skeletal muscle fibers (HP:0003687)2.12445754
122Abnormal umbilical cord blood vessels (HP:0011403)2.10668636
123Single umbilical artery (HP:0001195)2.10668636
124Abnormality of the fetal cardiovascular system (HP:0010948)2.10668636
125Genu recurvatum (HP:0002816)2.10018493
126Ovoid vertebral bodies (HP:0003300)2.07826200
127Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.07453591
128Vertebral hypoplasia (HP:0008417)2.07453591
129Exercise-induced myalgia (HP:0003738)2.07143972
130Hypoplastic pelvis (HP:0008839)2.06724934
131Aplasia/Hypoplasia involving the vertebral column (HP:0008518)2.06077828
132Preauricular pit (HP:0004467)2.04663342
133Periauricular skin pits (HP:0100277)2.04663342
134Tracheomalacia (HP:0002779)2.04565224
135Testicular atrophy (HP:0000029)2.04410873
136Breech presentation (HP:0001623)2.03405542
137Asymmetric septal hypertrophy (HP:0001670)2.03392637
138Ragged-red muscle fibers (HP:0003200)2.03048980
139Flared iliac wings (HP:0002869)2.00784331
140Nonimmune hydrops fetalis (HP:0001790)2.00330163
141Hypoplasia of the iris (HP:0007676)1.99854717
142Rhizomelia (HP:0008905)1.99099937
143EMG: myopathic abnormalities (HP:0003458)1.98252448
144Hypoplastic ilia (HP:0000946)1.97708200
145Patent foramen ovale (HP:0001655)1.97114752
146Abnormality of the 2nd finger (HP:0004100)1.96678359
147Carpal bone hypoplasia (HP:0001498)1.95979086
148Abnormal hand bone ossification (HP:0010660)1.95321348
149J-shaped sella turcica (HP:0002680)1.94114004
150Follicular hyperkeratosis (HP:0007502)1.93279964
151Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92779999
152Abnormality of polysaccharide metabolism (HP:0011012)1.92779999
153Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92779999
154Abnormal ossification of hand bones (HP:0005921)1.92112987
155Cerebral aneurysm (HP:0004944)1.91699287
156Hip contracture (HP:0003273)1.90696921
157Upper motor neuron abnormality (HP:0002127)1.90635881
158Abnormality of the acetabulum (HP:0003170)1.90598539
159Abnormality of the frontal sinuses (HP:0002687)1.89983195
160Abnormal ventriculo-arterial connection (HP:0011563)1.89626643
161Transposition of the great arteries (HP:0001669)1.89626643
162Abnormal connection of the cardiac segments (HP:0011545)1.89626643
163Coronal craniosynostosis (HP:0004440)1.89597140
164Lumbar hyperlordosis (HP:0002938)1.89403086
165Limited elbow extension (HP:0001377)1.88872016
166Neck muscle weakness (HP:0000467)1.88068456
167Urinary glycosaminoglycan excretion (HP:0003541)1.87640347
168Mucopolysacchariduria (HP:0008155)1.87640347
169Short palm (HP:0004279)1.87327351
170Genu valgum (HP:0002857)1.87001583
171Coxa vara (HP:0002812)1.86769036
172Round face (HP:0000311)1.85464360
173Abnormality of the phalanges of the hallux (HP:0010057)1.85361465
174Morphological abnormality of the inner ear (HP:0011390)1.84209596
175Muscle stiffness (HP:0003552)1.84024651
176Bladder diverticulum (HP:0000015)1.83219218
177Redundant skin (HP:0001582)1.81996989
178Stillbirth (HP:0003826)1.81991645
179Reticulocytopenia (HP:0001896)1.81271273
180Aplasia/Hypoplasia of the macula (HP:0008059)1.80878554
181Deformed sella turcica (HP:0002681)1.80462312
182Limb-girdle muscle weakness (HP:0003325)1.80204596
183Ectopia lentis (HP:0001083)1.79788857
184Abnormality of the odontoid process (HP:0003310)1.79279977
185Abnormality of the wing of the ilium (HP:0011867)1.79239787
186Absent phalangeal crease (HP:0006109)1.78864091
187Premature skin wrinkling (HP:0100678)1.78630257
18811 pairs of ribs (HP:0000878)1.77546836
189Vertebral clefting (HP:0008428)1.77194107
190Wormian bones (HP:0002645)1.77102516
191Blue sclerae (HP:0000592)1.76535502
192Broad ribs (HP:0000885)1.75133619
193Biconcave vertebral bodies (HP:0004586)1.74774751
194Hypertriglyceridemia (HP:0002155)1.73975918
195Synostosis of carpal bones (HP:0005048)1.73640688
196Abnormality of the lower motor neuron (HP:0002366)1.73435308
197Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.70645154
198Short 5th finger (HP:0009237)1.70554939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.75395549
2MAP3K34.05355263
3TRIB34.03666082
4VRK23.90192290
5NME23.71192386
6SMG13.66176496
7AKT33.55641274
8IRAK13.49624704
9CASK3.27070683
10STK243.07823246
11PRKD32.93913233
12TAF12.84763229
13IRAK32.73095694
14EPHB22.71500840
15MKNK12.64791786
16PLK22.63073849
17MKNK22.60965494
18ERBB32.42456290
19STK38L2.41425767
20TAOK22.24669486
21ICK2.17475048
22TESK12.10965929
23WEE12.07845116
24LATS22.06361361
25PIK3CA2.01747799
26BUB12.00511163
27PRKG21.97920454
28NEK61.96539968
29TTN1.95442935
30SGK31.90272385
31YES11.86347692
32SGK21.85038628
33MAP2K31.78535143
34MOS1.75722716
35RIPK11.71007624
36INSRR1.68107219
37DYRK31.65980815
38OBSCN1.60377478
39DYRK1A1.50431178
40STK161.49991703
41MAP3K111.47410730
42MAPK71.39053254
43KDR1.38897486
44SGK2231.37302062
45SGK4941.37302062
46FRK1.33951888
47ERN11.32509205
48EEF2K1.28594527
49IRAK21.27052864
50IRAK41.26868840
51ARAF1.25276497
52PDK21.21457862
53MAPK131.20304605
54EIF2AK21.20031073
55PLK31.19723438
56GRK51.19047615
57NUAK11.18303800
58STK31.17199348
59TGFBR11.13858747
60ROCK11.07635900
61NEK91.07198255
62NME11.07015147
63MYLK1.02261040
64LRRK21.01702922
65BCR1.01549578
66MAPKAPK50.99544916
67BLK0.98290015
68PTK2B0.98237984
69KSR20.96781724
70BRD40.94512835
71MAP3K20.94370408
72CDK120.94143650
73PBK0.93766326
74MAP3K80.93446334
75PRKCE0.92916481
76PIK3CG0.91691419
77PRKCI0.90594089
78SIK30.90360998
79STK40.89948921
80CDK90.87943355
81MAPK120.86223837
82MUSK0.84932288
83DMPK0.84136614
84MAP3K10.82473515
85ERBB40.80998637
86FER0.80605192
87TSSK60.80279150
88CDK80.80266632
89PIM20.79639943
90CHUK0.77248312
91SCYL20.76168919
92SIK10.76105317
93ABL20.72878199
94PDPK10.72654952
95ZAK0.72281816
96RPS6KB20.68685387
97MAP3K130.66030846
98GRK10.65936545
99ROCK20.65033850
100MAPK110.63733644
101MAP3K60.63437006
102GSK3A0.63108756
103CAMKK20.62064099
104AURKA0.61542579
105PKN20.60114997
106PASK0.59774166
107CDC70.59631664
108MAP2K20.57893820
109RPS6KB10.57035702
110BRAF0.54041142
111MAP3K100.53741733
112ADRBK10.53407879
113DAPK30.51736827
114TRPM70.51410241
115PAK10.50807772
116NEK20.50074188
117LIMK10.49735041
118TIE10.49311985
119DYRK20.48744475
120PTK20.48738213
121KSR10.48524871
122CDK40.48318948
123CHEK20.48131370
124MAPK40.46809923
125MTOR0.46530402
126MET0.46336226
127PRKCH0.46021918
128AKT20.45995381
129PNCK0.45687658
130PIM10.44936184
131LATS10.44296587
132HIPK20.44080257
133MINK10.44006777
134VRK10.43586377
135PRPF4B0.42906426
136JAK30.42405125
137BMPR20.41291625
138MAP2K10.41101299
139CLK10.40319315
140UHMK10.39465599
141PRKCG0.39045422
142PTK60.38945254
143TGFBR20.36975090
144CHEK10.36399611
145MAP2K60.35622171
146IGF1R0.35371070
147ILK0.34804023
148CSNK1G10.34795482
149MARK30.34369757
150GRK60.34293457
151EPHA20.33672581
152TBK10.31104180
153MST40.30758374
154BCKDK0.30362853
155CDC42BPA0.30259517
156PAK20.30024455
157BRSK20.29381411
158MARK10.27986035
159SGK10.27849709
160PDGFRB0.27641082
161PRKCZ0.27204695
162MELK0.27040814
163NLK0.26897484
164CDK70.26394159
165SRPK10.26137886
166PRKG10.25988013
167PAK40.23424768
168PLK10.23254606
169CDK30.23210484
170PRKACA0.23075399
171PRKD10.22036067
172CAMK2A0.21186632
173PDGFRA0.21093938
174PRKCQ0.20147911
175MAPKAPK20.19892967
176BRSK10.17682473

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005325.44603247
2ECM-receptor interaction_Homo sapiens_hsa045124.77951110
3Protein digestion and absorption_Homo sapiens_hsa049744.66436703
4Cyanoamino acid metabolism_Homo sapiens_hsa004604.63274128
5Ribosome_Homo sapiens_hsa030104.30672389
6Sulfur relay system_Homo sapiens_hsa041223.02460795
7DNA replication_Homo sapiens_hsa030302.97136513
8Focal adhesion_Homo sapiens_hsa045102.68907128
9Bladder cancer_Homo sapiens_hsa052192.03083296
10Notch signaling pathway_Homo sapiens_hsa043302.00949828
11TGF-beta signaling pathway_Homo sapiens_hsa043501.97578444
12PI3K-Akt signaling pathway_Homo sapiens_hsa041511.94379116
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.92551771
14Nucleotide excision repair_Homo sapiens_hsa034201.85530812
15Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.84205971
16Axon guidance_Homo sapiens_hsa043601.78843062
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72307425
18Dilated cardiomyopathy_Homo sapiens_hsa054141.71854374
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.65632384
20Hippo signaling pathway_Homo sapiens_hsa043901.62789616
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60803667
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54546434
23Pyrimidine metabolism_Homo sapiens_hsa002401.52777353
24Basal cell carcinoma_Homo sapiens_hsa052171.51785790
25Gap junction_Homo sapiens_hsa045401.47771874
26Non-small cell lung cancer_Homo sapiens_hsa052231.46252115
27Thyroid cancer_Homo sapiens_hsa052161.46096396
28Olfactory transduction_Homo sapiens_hsa047401.42787836
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42428462
30Fatty acid elongation_Homo sapiens_hsa000621.39340401
31Spliceosome_Homo sapiens_hsa030401.38580359
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.37321882
33Adherens junction_Homo sapiens_hsa045201.31431354
34RNA polymerase_Homo sapiens_hsa030201.29885247
35Cell cycle_Homo sapiens_hsa041101.29474823
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.29240582
37Chronic myeloid leukemia_Homo sapiens_hsa052201.23975944
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.22825069
39p53 signaling pathway_Homo sapiens_hsa041151.21037114
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19031684
41Proteoglycans in cancer_Homo sapiens_hsa052051.15725482
42Circadian entrainment_Homo sapiens_hsa047131.15448620
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14796110
44Long-term depression_Homo sapiens_hsa047301.14016622
45Prostate cancer_Homo sapiens_hsa052151.13497532
46MicroRNAs in cancer_Homo sapiens_hsa052061.10410896
47Rap1 signaling pathway_Homo sapiens_hsa040151.08127129
48Huntingtons disease_Homo sapiens_hsa050161.07927268
49Fructose and mannose metabolism_Homo sapiens_hsa000511.06239725
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05915625
51Endometrial cancer_Homo sapiens_hsa052131.05789568
52Melanoma_Homo sapiens_hsa052181.05516787
53Oxidative phosphorylation_Homo sapiens_hsa001901.04489059
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03777751
55Wnt signaling pathway_Homo sapiens_hsa043101.01581374
56Pentose phosphate pathway_Homo sapiens_hsa000300.97517415
57Parkinsons disease_Homo sapiens_hsa050120.97178112
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96829705
59Insulin signaling pathway_Homo sapiens_hsa049100.96263486
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95628654
61Tight junction_Homo sapiens_hsa045300.94821319
62Melanogenesis_Homo sapiens_hsa049160.93127978
63Oxytocin signaling pathway_Homo sapiens_hsa049210.91254998
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89437620
65Glutathione metabolism_Homo sapiens_hsa004800.88252368
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87931193
67Renin secretion_Homo sapiens_hsa049240.87544198
68Base excision repair_Homo sapiens_hsa034100.86878297
69Prion diseases_Homo sapiens_hsa050200.86783864
70Lysosome_Homo sapiens_hsa041420.85670608
71Retinol metabolism_Homo sapiens_hsa008300.85234159
72Alzheimers disease_Homo sapiens_hsa050100.85169918
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.84861312
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84808142
75Acute myeloid leukemia_Homo sapiens_hsa052210.82777585
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81708433
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81458637
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80443427
79Cholinergic synapse_Homo sapiens_hsa047250.79948874
80Biosynthesis of amino acids_Homo sapiens_hsa012300.78530476
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.78270179
82Pancreatic cancer_Homo sapiens_hsa052120.77904989
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77734820
84Small cell lung cancer_Homo sapiens_hsa052220.74445287
85Purine metabolism_Homo sapiens_hsa002300.74160898
86Hedgehog signaling pathway_Homo sapiens_hsa043400.74080227
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.72659681
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71836394
89AMPK signaling pathway_Homo sapiens_hsa041520.71655194
90HTLV-I infection_Homo sapiens_hsa051660.71034266
91Pathways in cancer_Homo sapiens_hsa052000.70823844
92Nicotine addiction_Homo sapiens_hsa050330.69954764
93Vibrio cholerae infection_Homo sapiens_hsa051100.69016240
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68660582
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68470647
96Serotonergic synapse_Homo sapiens_hsa047260.66087004
97Colorectal cancer_Homo sapiens_hsa052100.65599155
98mTOR signaling pathway_Homo sapiens_hsa041500.65202622
99Renin-angiotensin system_Homo sapiens_hsa046140.64895534
100Homologous recombination_Homo sapiens_hsa034400.64756191
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63836050
102Malaria_Homo sapiens_hsa051440.63792371
103Toxoplasmosis_Homo sapiens_hsa051450.62577442
104Ras signaling pathway_Homo sapiens_hsa040140.62423464
105Shigellosis_Homo sapiens_hsa051310.62407892
106VEGF signaling pathway_Homo sapiens_hsa043700.62292440
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62271091
108Cardiac muscle contraction_Homo sapiens_hsa042600.62212446
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61945034
110Renal cell carcinoma_Homo sapiens_hsa052110.60748438
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60432407
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56096532
113N-Glycan biosynthesis_Homo sapiens_hsa005100.54870208
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54793198
115Ovarian steroidogenesis_Homo sapiens_hsa049130.54053063
116cAMP signaling pathway_Homo sapiens_hsa040240.52774732
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52733444
118Epstein-Barr virus infection_Homo sapiens_hsa051690.52151560
119GABAergic synapse_Homo sapiens_hsa047270.52108863
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51323171
121Glioma_Homo sapiens_hsa052140.50852720
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49667978
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49397141
124Viral carcinogenesis_Homo sapiens_hsa052030.49105215
125Sulfur metabolism_Homo sapiens_hsa009200.48071141
126Oocyte meiosis_Homo sapiens_hsa041140.48053425
127Morphine addiction_Homo sapiens_hsa050320.47368748
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47311468
129beta-Alanine metabolism_Homo sapiens_hsa004100.47222310
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47214476
131MAPK signaling pathway_Homo sapiens_hsa040100.47112817
132Long-term potentiation_Homo sapiens_hsa047200.46926834
133Amphetamine addiction_Homo sapiens_hsa050310.46496683
134Basal transcription factors_Homo sapiens_hsa030220.46095321
135Platelet activation_Homo sapiens_hsa046110.44651125
136Dopaminergic synapse_Homo sapiens_hsa047280.44258726
137B cell receptor signaling pathway_Homo sapiens_hsa046620.44159799
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44118351
139Starch and sucrose metabolism_Homo sapiens_hsa005000.43891768
140Arginine and proline metabolism_Homo sapiens_hsa003300.43678288
141Salivary secretion_Homo sapiens_hsa049700.42922835
142Pyruvate metabolism_Homo sapiens_hsa006200.41874949
143Arachidonic acid metabolism_Homo sapiens_hsa005900.41129070
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40785799
145Other glycan degradation_Homo sapiens_hsa005110.40492908
146Mismatch repair_Homo sapiens_hsa034300.40478551
147Hepatitis B_Homo sapiens_hsa051610.40096126
148Carbon metabolism_Homo sapiens_hsa012000.39855500
149Osteoclast differentiation_Homo sapiens_hsa043800.39588735
150Galactose metabolism_Homo sapiens_hsa000520.39583060
151Cysteine and methionine metabolism_Homo sapiens_hsa002700.38969074
152Primary bile acid biosynthesis_Homo sapiens_hsa001200.36675568
153Cocaine addiction_Homo sapiens_hsa050300.36458704
154HIF-1 signaling pathway_Homo sapiens_hsa040660.36271141
155RNA transport_Homo sapiens_hsa030130.35916955
156Insulin resistance_Homo sapiens_hsa049310.34316558

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