KLF10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1production of molecular mediator involved in inflammatory response (GO:0002532)4.48571380
2ER overload response (GO:0006983)4.03074118
3nuclear pore organization (GO:0006999)3.91340335
4cellular response to glucose starvation (GO:0042149)3.86122585
5response to peptidoglycan (GO:0032494)3.74792012
6negative regulation of thymocyte apoptotic process (GO:0070244)3.66128287
7germinal center formation (GO:0002467)3.61604866
8embryonic process involved in female pregnancy (GO:0060136)3.57658215
9growth hormone receptor signaling pathway (GO:0060396)3.56106602
10detection of other organism (GO:0098543)3.41740793
11interleukin-6-mediated signaling pathway (GO:0070102)3.40715514
12regulation of oxidative stress-induced neuron death (GO:1903203)3.35055502
13nuclear pore complex assembly (GO:0051292)3.31808905
14cellular response to antibiotic (GO:0071236)3.31370106
15regulation of posttranscriptional gene silencing (GO:0060147)3.28972843
16regulation of gene silencing by miRNA (GO:0060964)3.28972843
17regulation of gene silencing by RNA (GO:0060966)3.28972843
18cellular response to arsenic-containing substance (GO:0071243)3.23677384
19ribosomal small subunit assembly (GO:0000028)3.18264983
20response to muramyl dipeptide (GO:0032495)3.17496744
21cellular response to growth hormone stimulus (GO:0071378)3.13253008
22regulation of germinal center formation (GO:0002634)3.13191479
23COPII vesicle coating (GO:0048208)3.04110090
24neutrophil activation involved in immune response (GO:0002283)2.92896967
25detection of molecule of bacterial origin (GO:0032490)2.92512044
26negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.90745910
27definitive hemopoiesis (GO:0060216)2.89748794
28negative regulation of B cell apoptotic process (GO:0002903)2.89401271
29positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.88678092
30mRNA transcription from RNA polymerase II promoter (GO:0042789)2.86981259
31negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.86767847
32negative regulation of T-helper cell differentiation (GO:0045623)2.86767847
33regulation of B cell apoptotic process (GO:0002902)2.83344672
34cellular extravasation (GO:0045123)2.82403868
35IMP biosynthetic process (GO:0006188)2.79653530
36cellular response to ethanol (GO:0071361)2.69328547
37regulation of transforming growth factor beta1 production (GO:0032908)2.68733133
38nucleobase biosynthetic process (GO:0046112)2.68326815
39endothelial cell chemotaxis (GO:0035767)2.67961363
40purine nucleobase biosynthetic process (GO:0009113)2.67220616
41inositol phosphate catabolic process (GO:0071545)2.66351661
42negative regulation of interleukin-8 production (GO:0032717)2.66302016
43DNA replication checkpoint (GO:0000076)2.64631578
44regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.64483001
45detection of external biotic stimulus (GO:0098581)2.63737763
46interleukin-1-mediated signaling pathway (GO:0070498)2.63370063
47regulation of nuclear cell cycle DNA replication (GO:0033262)2.62788197
48positive regulation of leukocyte degranulation (GO:0043302)2.62053331
49pore complex assembly (GO:0046931)2.61824775
50positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.59609763
51hypotonic response (GO:0006971)2.58730138
52poly(A)+ mRNA export from nucleus (GO:0016973)2.57917457
53wound healing, spreading of epidermal cells (GO:0035313)2.57100411
54establishment of endothelial barrier (GO:0061028)2.56664683
55negative regulation of glycoprotein biosynthetic process (GO:0010561)2.56517685
56regulation of energy homeostasis (GO:2000505)2.56365012
57regulation of p38MAPK cascade (GO:1900744)2.56352548
58entrainment of circadian clock by photoperiod (GO:0043153)2.56160053
59regulation of vitamin D biosynthetic process (GO:0060556)2.55531542
60positive regulation of mast cell degranulation (GO:0043306)2.54110309
61positive regulation of mast cell activation involved in immune response (GO:0033008)2.54110309
62hemidesmosome assembly (GO:0031581)2.52711379
63positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.52286934
64regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.52286934
65regulation of T-helper 2 cell differentiation (GO:0045628)2.51426228
66IMP metabolic process (GO:0046040)2.51191093
67protein K6-linked ubiquitination (GO:0085020)2.50956178
68metaphase plate congression (GO:0051310)2.50416769
69purine nucleotide salvage (GO:0032261)2.49555598
70positive regulation of keratinocyte differentiation (GO:0045618)2.49290235
71megakaryocyte development (GO:0035855)2.47815093
72negative regulation of Rho protein signal transduction (GO:0035024)2.47444027
73mitotic metaphase plate congression (GO:0007080)2.47192466
74COPI coating of Golgi vesicle (GO:0048205)2.46217621
75Golgi transport vesicle coating (GO:0048200)2.46217621
76negative regulation of erythrocyte differentiation (GO:0045647)2.45821623
77maturation of SSU-rRNA (GO:0030490)2.45462235
78positive regulation of vasculogenesis (GO:2001214)2.45170016
79purinergic nucleotide receptor signaling pathway (GO:0035590)2.45164971
80cellular response to gonadotropin stimulus (GO:0071371)2.44682538
81response to dsRNA (GO:0043331)2.44332294
82viral protein processing (GO:0019082)2.44145331
83positive regulation of glycolytic process (GO:0045821)2.44045991
84regulation of double-strand break repair via homologous recombination (GO:0010569)2.43615702
85entrainment of circadian clock (GO:0009649)2.43210806
86platelet-derived growth factor receptor signaling pathway (GO:0048008)2.43028364
87regulation of cell proliferation involved in kidney development (GO:1901722)2.42922180
88chaperone mediated protein folding requiring cofactor (GO:0051085)2.42848982
89positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.42691314
90antigen processing and presentation of endogenous antigen (GO:0019883)2.41966970
91negative regulation of acute inflammatory response (GO:0002674)2.41595075
92mRNA transcription (GO:0009299)2.37415056
93G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.37052807
94positive regulation of odontogenesis (GO:0042482)2.36942974
95purine-containing compound salvage (GO:0043101)2.35799640
96positive regulation of p38MAPK cascade (GO:1900745)2.35784122
97negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.33976305
98negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.33324553
99nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.33186469
100response to progesterone (GO:0032570)2.32857171
101cellular response to fluid shear stress (GO:0071498)2.32813377
102Arp2/3 complex-mediated actin nucleation (GO:0034314)2.32536030
103histone mRNA catabolic process (GO:0071044)2.31755108
104negative regulation of complement activation (GO:0045916)2.31475872
105positive regulation of transforming growth factor beta production (GO:0071636)2.31007755
106formation of translation preinitiation complex (GO:0001731)2.30836026
107DNA replication initiation (GO:0006270)2.30404875
108positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.30364322
109regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.30222106
110protein K11-linked deubiquitination (GO:0035871)2.29878508
111regulation of T-helper 1 cell differentiation (GO:0045625)2.29801537
112response to hepatocyte growth factor (GO:0035728)2.29568685
113cellular response to hepatocyte growth factor stimulus (GO:0035729)2.29568685
114positive regulation of SMAD protein import into nucleus (GO:0060391)2.29189509
115regulation of SMAD protein import into nucleus (GO:0060390)2.29184907
116somatic hypermutation of immunoglobulin genes (GO:0016446)2.28746172
117somatic diversification of immune receptors via somatic mutation (GO:0002566)2.28746172
118intestinal epithelial cell development (GO:0060576)2.27726073
119histamine secretion (GO:0001821)2.27640242
120response to arsenic-containing substance (GO:0046685)2.26943784
121negative regulation of mast cell activation (GO:0033004)2.26122478
122oligosaccharide catabolic process (GO:0009313)2.25733538
123establishment of chromosome localization (GO:0051303)2.25471489
124B cell mediated immunity (GO:0019724)2.24924184
125positive regulation by symbiont of host defense response (GO:0052509)2.24135017
126modulation by symbiont of host defense response (GO:0052031)2.24135017
127modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.24135017
128modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.24135017
129positive regulation by organism of defense response of other organism involved in symbiotic interact2.24135017
130modulation by symbiont of host immune response (GO:0052553)2.24135017
131positive regulation of epidermal cell differentiation (GO:0045606)2.23854325
132mitotic G2/M transition checkpoint (GO:0044818)2.23784906
133mitotic nuclear envelope disassembly (GO:0007077)2.23690288
134ribosome biogenesis (GO:0042254)2.23241688
135cellular response to interleukin-6 (GO:0071354)2.23239020
136histone H4-K12 acetylation (GO:0043983)2.22834286
137desmosome organization (GO:0002934)2.22637597
138hepatocyte apoptotic process (GO:0097284)2.22438640
139positive regulation of mast cell activation (GO:0033005)2.20980677
140maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.20476073
141establishment of skin barrier (GO:0061436)2.20292428
142ribosome assembly (GO:0042255)2.20193506
143positive regulation of autophagy (GO:0010508)2.20047294
144regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.19644801
145telomere maintenance via semi-conservative replication (GO:0032201)2.19643680
146detection of biotic stimulus (GO:0009595)2.19497529
147detection of bacterium (GO:0016045)2.19087077
148mature B cell differentiation involved in immune response (GO:0002313)2.18924845
149RNA destabilization (GO:0050779)2.18734747
150regulation of T-helper cell differentiation (GO:0045622)2.17824103
151regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.17393165
152positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.17393165
153membrane budding (GO:0006900)2.17329013
154positive regulation of protein import into nucleus, translocation (GO:0033160)2.16980585
155regulation of integrin activation (GO:0033623)2.16699276
156cellular response to thyroid hormone stimulus (GO:0097067)2.16477823
157B cell differentiation (GO:0030183)2.16395772
158mitochondrial DNA replication (GO:0006264)2.16038414
159dosage compensation (GO:0007549)2.15983608
160phosphorylated carbohydrate dephosphorylation (GO:0046838)2.15371264
161inositol phosphate dephosphorylation (GO:0046855)2.15371264
162negative regulation of DNA-dependent DNA replication (GO:2000104)2.15236745
163regulation of vitamin metabolic process (GO:0030656)2.15207628
164regulation of gene silencing (GO:0060968)2.14452864
165embryonic placenta development (GO:0001892)2.14363742
166transcytosis (GO:0045056)2.11175681
167positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.11079130
168regulation of mitotic spindle checkpoint (GO:1903504)2.10207642
169regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.10207642
170regulation of interleukin-8 secretion (GO:2000482)2.09751663
171telomere maintenance via recombination (GO:0000722)2.09578881
172regulation of apoptotic cell clearance (GO:2000425)2.09453299
173regulation of interleukin-12 biosynthetic process (GO:0045075)2.09337460
174immunoglobulin mediated immune response (GO:0016064)2.08791776
175positive regulation of interferon-beta production (GO:0032728)2.08770480
176regulation of dendritic cell antigen processing and presentation (GO:0002604)2.07950060
177membrane disassembly (GO:0030397)2.07575303
178nuclear envelope disassembly (GO:0051081)2.07575303
179peptide catabolic process (GO:0043171)2.06795618
180regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.06312228
181fibroblast migration (GO:0010761)2.06245797
182regulation of interferon-beta biosynthetic process (GO:0045357)2.04604178
183negative regulation of protein autophosphorylation (GO:0031953)2.04334722
1843-UTR-mediated mRNA stabilization (GO:0070935)2.03896597
185DNA strand elongation involved in DNA replication (GO:0006271)2.03499716
186chromatin remodeling at centromere (GO:0031055)2.03383764
187regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.03364219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.10534570
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.12765377
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.93510700
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.42691205
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.42691205
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.42691205
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.92367665
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.38724140
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.24131237
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.17117442
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.12412235
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.12186691
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12147158
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11972519
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07583915
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.03848230
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.99629777
18ESR1_21235772_ChIP-Seq_MCF-7_Human1.98149935
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94207231
20* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88093028
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85803155
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81919967
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.80318572
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.78619625
25ZNF263_19887448_ChIP-Seq_K562_Human1.76438762
26* IRF8_27001747_Chip-Seq_BMDM_Mouse1.74559563
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.73831326
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72100557
29FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.71098233
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70801272
31* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67921940
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66753348
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65016301
34ELK1_19687146_ChIP-ChIP_HELA_Human1.64757487
35CLOCK_20551151_ChIP-Seq_293T_Human1.64501107
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64262028
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64084342
38VDR_24787735_ChIP-Seq_THP-1_Human1.63505072
39* BRD4_25478319_ChIP-Seq_HGPS_Human1.59396324
40* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58245447
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57767244
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52149583
43* CJUN_26792858_Chip-Seq_BT549_Human1.52145894
44* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51500355
45JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51299392
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50585873
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48059709
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47813867
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.47717734
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46713327
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44258065
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43366346
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43095959
54* MYB_26560356_Chip-Seq_TH2_Human1.41950109
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40817386
56SCL_19346495_ChIP-Seq_HPC-7_Human1.40337289
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.40083545
58JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39743342
59* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38054710
60* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37645315
61* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37645315
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37131760
63NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.36884897
64RUNX_20019798_ChIP-Seq_JUKART_Human1.35536942
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34896210
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31811609
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.31481986
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.29049655
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28921689
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28883963
71LXR_22158963_ChIP-Seq_LIVER_Mouse1.27811891
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.26194554
73* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.25399560
74* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24539236
75* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23658519
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23014810
77VDR_23849224_ChIP-Seq_CD4+_Human1.22417218
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22327532
79SOX2_20726797_ChIP-Seq_SW620_Human1.21810763
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.21721626
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21321636
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19659053
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.19269402
84GABP_17652178_ChIP-ChIP_JURKAT_Human1.19254782
85FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19236963
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18371982
87EST1_17652178_ChIP-ChIP_JURKAT_Human1.17833405
88VDR_24763502_ChIP-Seq_THP-1_Human1.17822946
89FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17417135
90EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17037833
91AR_21909140_ChIP-Seq_LNCAP_Human1.16478835
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.16374907
93TCF3_18692474_ChIP-Seq_MESCs_Mouse1.15547288
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15313854
95* ATF3_27146783_Chip-Seq_COLON_Human1.14958020
96GATA3_27048872_Chip-Seq_THYMUS_Human1.14267088
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13596515
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13196374
99* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12825739
100MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12751077
101TP63_23658742_ChIP-Seq_EP156T_Human1.12648632
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12603440
103NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12603440
104* SPI1_23547873_ChIP-Seq_NB4_Human1.12075654
105MYB_26560356_Chip-Seq_TH1_Human1.11559666
106* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10450542
107* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09877140
108Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09644348
109* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08274154
110GATA3_24758297_ChIP-Seq_MCF-7_Human1.08208755
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07483366
112CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07323663
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07043734
114PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04662676
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04220156
116MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04003214
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03255350
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02676479
119RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02589939
120SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01911602
121FOXP3_21729870_ChIP-Seq_TREG_Human1.01512447
122* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01317661
123* RUNX1_22412390_ChIP-Seq_EML_Mouse1.01182978
124SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01148360
125DCP1A_22483619_ChIP-Seq_HELA_Human1.01043739
126SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99628072
127TRIM28_21343339_ChIP-Seq_HEK293_Human0.98747424
128PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98385904
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98243265
130SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97683046
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97411759
132MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97344109
133* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97223101
134TFEB_21752829_ChIP-Seq_HELA_Human0.96880429
135PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96750390
136IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95176830
137RXR_22158963_ChIP-Seq_LIVER_Mouse0.95157699
138CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95038718
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94192284
140AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94048517
141SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92812817
142STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92739472
143FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92557713
144LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92466588
145EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92349065
146RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91815541
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91747328
148TP63_19390658_ChIP-ChIP_HaCaT_Human0.91313457
149* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91307573
150ESR2_21235772_ChIP-Seq_MCF-7_Human0.91185314
151* XRN2_22483619_ChIP-Seq_HELA_Human0.91152513
152* MYC_22102868_ChIP-Seq_BL_Human0.91022146
153SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90990474
154GATA1_22025678_ChIP-Seq_K562_Human0.89473438
155FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88726635
156FOXA1_25552417_ChIP-Seq_VCAP_Human0.86405061
157ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85771666
158CDX2_22108803_ChIP-Seq_LS180_Human0.85677204
159KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85264520
160PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84898400
161CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84669156

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system3.29335118
2MP0002006_tumorigenesis2.68072033
3MP0002877_abnormal_melanocyte_morpholog2.65199296
4MP0003693_abnormal_embryo_hatching2.55447786
5MP0006054_spinal_hemorrhage2.52483855
6MP0003724_increased_susceptibility_to2.41686531
7MP0008007_abnormal_cellular_replicative2.27988362
8MP0000013_abnormal_adipose_tissue2.26151831
9MP0004957_abnormal_blastocyst_morpholog2.08961820
10MP0010094_abnormal_chromosome_stability2.02029976
11MP0010352_gastrointestinal_tract_polyps2.00302808
12MP0003941_abnormal_skin_development1.98585196
13MP0003656_abnormal_erythrocyte_physiolo1.91617216
14MP0003828_pulmonary_edema1.82329990
15MP0000685_abnormal_immune_system1.80741232
16MP0004264_abnormal_extraembryonic_tissu1.79027786
17MP0003566_abnormal_cell_adhesion1.78363532
18MP0004808_abnormal_hematopoietic_stem1.78257683
19MP0010368_abnormal_lymphatic_system1.75942239
20MP0003950_abnormal_plasma_membrane1.73973264
21MP0009278_abnormal_bone_marrow1.72643841
22MP0008057_abnormal_DNA_replication1.71914075
23MP0002009_preneoplasia1.65081670
24MP0003436_decreased_susceptibility_to1.63292821
25MP0003786_premature_aging1.62294508
26MP0005367_renal/urinary_system_phenotyp1.58347237
27MP0000516_abnormal_urinary_system1.58347237
28MP0010307_abnormal_tumor_latency1.57050359
29MP0003077_abnormal_cell_cycle1.56153489
30MP0005451_abnormal_body_composition1.55677753
31MP0010678_abnormal_skin_adnexa1.54253959
32MP0004782_abnormal_surfactant_physiolog1.51810482
33MP0004084_abnormal_cardiac_muscle1.50157856
34MP0002332_abnormal_exercise_endurance1.49050853
35MP0000490_abnormal_crypts_of1.46419529
36MP0005076_abnormal_cell_differentiation1.44695155
37MP0005397_hematopoietic_system_phenotyp1.44535321
38MP0001545_abnormal_hematopoietic_system1.44535321
39MP0003191_abnormal_cellular_cholesterol1.44143970
40MP0000465_gastrointestinal_hemorrhage1.43056748
41MP0002876_abnormal_thyroid_physiology1.42875864
42MP0001879_abnormal_lymphatic_vessel1.41569796
43MP0002132_abnormal_respiratory_system1.41517339
44MP0002060_abnormal_skin_morphology1.41314262
45MP0005023_abnormal_wound_healing1.40616903
46MP0008058_abnormal_DNA_repair1.39316170
47MP0004272_abnormal_basement_membrane1.37318194
48MP0009333_abnormal_splenocyte_physiolog1.34610041
49MP0001835_abnormal_antigen_presentation1.30411171
50MP0002396_abnormal_hematopoietic_system1.29511398
51MP0009697_abnormal_copulation1.23857199
52MP0003111_abnormal_nucleus_morphology1.23550454
53MP0000383_abnormal_hair_follicle1.23489920
54MP0002796_impaired_skin_barrier1.22781782
55MP0009764_decreased_sensitivity_to1.22615057
56MP0003448_altered_tumor_morphology1.20174004
57MP0010155_abnormal_intestine_physiology1.20068847
58MP0003279_aneurysm1.17390982
59MP0003705_abnormal_hypodermis_morpholog1.15962172
60MP0001533_abnormal_skeleton_physiology1.15730505
61MP0004883_abnormal_blood_vessel1.15369720
62MP0010234_abnormal_vibrissa_follicle1.15288818
63MP0005646_abnormal_pituitary_gland1.14912527
64MP0004036_abnormal_muscle_relaxation1.13017467
65MP0001853_heart_inflammation1.12937116
66MP0003300_gastrointestinal_ulcer1.12407315
67MP0000858_altered_metastatic_potential1.11960859
68MP0001873_stomach_inflammation1.09225229
69MP0002998_abnormal_bone_remodeling1.09202518
70MP0009840_abnormal_foam_cell1.07771734
71MP0001243_abnormal_dermal_layer1.07381142
72MP0003091_abnormal_cell_migration1.06308788
73MP0000767_abnormal_smooth_muscle1.06229837
74MP0002086_abnormal_extraembryonic_tissu1.06200941
75MP0005220_abnormal_exocrine_pancreas1.03193126
76MP0001800_abnormal_humoral_immune1.02984215
77MP0005275_abnormal_skin_tensile1.02650601
78MP0003075_altered_response_to1.01713275
79MP0001191_abnormal_skin_condition1.01704269
80MP0002405_respiratory_system_inflammati1.01013653
81MP0002419_abnormal_innate_immunity1.00841692
82MP0005501_abnormal_skin_physiology1.00762214
83MP0001216_abnormal_epidermal_layer1.00046144
84MP0000350_abnormal_cell_proliferation0.99559013
85MP0003453_abnormal_keratinocyte_physiol0.99502465
86MP0003221_abnormal_cardiomyocyte_apopto0.99410366
87MP0008469_abnormal_protein_level0.99000544
88MP0002723_abnormal_immune_serum0.98550339
89MP0005390_skeleton_phenotype0.98338998
90MP0002971_abnormal_brown_adipose0.98018088
91MP0002254_reproductive_system_inflammat0.97972148
92MP0001915_intracranial_hemorrhage0.97822299
93MP0003195_calcinosis0.97678935
94MP0003567_abnormal_fetal_cardiomyocyte0.96706442
95MP0001790_abnormal_immune_system0.95013216
96MP0005387_immune_system_phenotype0.95013216
97MP0009379_abnormal_foot_pigmentation0.94664097
98MP0004947_skin_inflammation0.94232559
99MP0003943_abnormal_hepatobiliary_system0.93574375
100MP0009931_abnormal_skin_appearance0.91886226
101MP0005166_decreased_susceptibility_to0.91752815
102MP0005330_cardiomyopathy0.91022430
103MP0005535_abnormal_body_temperature0.89124561
104MP0000467_abnormal_esophagus_morphology0.88866656
105MP0001851_eye_inflammation0.88707058
106MP0002933_joint_inflammation0.88637643
107MP0003303_peritoneal_inflammation0.88633803
108MP0002148_abnormal_hypersensitivity_rea0.88610269
109MP0009780_abnormal_chondrocyte_physiolo0.88311690
110MP0001672_abnormal_embryogenesis/_devel0.88217959
111MP0005380_embryogenesis_phenotype0.88217959
112MP0002452_abnormal_antigen_presenting0.88163659
113MP0004484_altered_response_of0.88014323
114MP0000003_abnormal_adipose_tissue0.87135816
115MP0002019_abnormal_tumor_incidence0.86154052
116MP0003806_abnormal_nucleotide_metabolis0.85214505
117MP0002088_abnormal_embryonic_growth/wei0.84917953
118MP0001845_abnormal_inflammatory_respons0.84793139
119MP0002166_altered_tumor_susceptibility0.84787941
120MP0003984_embryonic_growth_retardation0.84759258
121MP0005464_abnormal_platelet_physiology0.84553972
122MP0005000_abnormal_immune_tolerance0.84320912
123MP0000689_abnormal_spleen_morphology0.84131132
124MP0000343_altered_response_to0.83226365
125MP0002127_abnormal_cardiovascular_syste0.82489155
126MP0005165_increased_susceptibility_to0.81741515
127MP0002693_abnormal_pancreas_physiology0.81494377
128MP0005164_abnormal_response_to0.81387599
129MP0005671_abnormal_response_to0.81086085
130MP0003763_abnormal_thymus_physiology0.80731497
131MP0008995_early_reproductive_senescence0.79787214
132MP0002722_abnormal_immune_system0.79287726
133MP0009785_altered_susceptibility_to0.79032617
134MP0005084_abnormal_gallbladder_morpholo0.78388609
135MP0004197_abnormal_fetal_growth/weight/0.78112563
136MP0002420_abnormal_adaptive_immunity0.77769831
137MP0002398_abnormal_bone_marrow0.77190585
138MP0005508_abnormal_skeleton_morphology0.76854255
139MP0008004_abnormal_stomach_pH0.76709659
140MP0000249_abnormal_blood_vessel0.76636865
141MP0005025_abnormal_response_to0.76276611
142MP0001819_abnormal_immune_cell0.76238710
143* MP0001542_abnormal_bone_strength0.76060146
144MP0002972_abnormal_cardiac_muscle0.73582341
145MP0008875_abnormal_xenobiotic_pharmacok0.73455691
146MP0001727_abnormal_embryo_implantation0.72630607
147MP0000716_abnormal_immune_system0.72214633

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)4.88946250
2Abnormality of B cell number (HP:0010975)4.71596140
3Elevated erythrocyte sedimentation rate (HP:0003565)4.03240430
4Panhypogammaglobulinemia (HP:0003139)3.81108894
5Nemaline bodies (HP:0003798)3.79069131
6Muscle fiber inclusion bodies (HP:0100299)3.69989537
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.58564632
8Metaphyseal dysplasia (HP:0100255)3.46499352
9Agnosia (HP:0010524)3.44538914
10Hypoproteinemia (HP:0003075)3.42697261
11Distal lower limb muscle weakness (HP:0009053)3.26458501
12Muscle fiber splitting (HP:0003555)3.18873320
13Eosinophilia (HP:0001880)2.97573201
14Exocrine pancreatic insufficiency (HP:0001738)2.95251277
1511 pairs of ribs (HP:0000878)2.84258488
16Stridor (HP:0010307)2.80002880
17Granulocytopenia (HP:0001913)2.75279090
18Thyroiditis (HP:0100646)2.75229240
19Nonimmune hydrops fetalis (HP:0001790)2.73524997
20Cervical subluxation (HP:0003308)2.73245031
21Diaphragmatic weakness (HP:0009113)2.72129908
22Birth length less than 3rd percentile (HP:0003561)2.69975554
23Fatigue (HP:0012378)2.65453307
24Rimmed vacuoles (HP:0003805)2.57747122
25Agammaglobulinemia (HP:0004432)2.56203137
26Orchitis (HP:0100796)2.54940680
27Severe combined immunodeficiency (HP:0004430)2.53092770
28Exercise-induced myalgia (HP:0003738)2.52311104
29Abnormality of the distal phalanges of the toes (HP:0010182)2.51901011
30Vertebral hypoplasia (HP:0008417)2.48910043
31Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.48910043
32Erythroderma (HP:0001019)2.48394800
33Chromsome breakage (HP:0040012)2.43204557
34Missing ribs (HP:0000921)2.40981198
35Myositis (HP:0100614)2.38814830
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38520069
37Limb-girdle muscle atrophy (HP:0003797)2.33109537
38Increased CSF protein (HP:0002922)2.32579121
39Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.31100335
40Cone-rod dystrophy (HP:0000548)2.30614129
41Myelodysplasia (HP:0002863)2.29777588
42Thrombocytosis (HP:0001894)2.24991641
43Long clavicles (HP:0000890)2.24566211
44Rhabdomyolysis (HP:0003201)2.23652212
45Type I transferrin isoform profile (HP:0003642)2.22607153
46Abnormality of the left ventricular outflow tract (HP:0011103)2.20320968
47Subaortic stenosis (HP:0001682)2.20320968
48Vacuolated lymphocytes (HP:0001922)2.16986398
49Myoglobinuria (HP:0002913)2.16570246
50Popliteal pterygium (HP:0009756)2.14521906
51Vascular calcification (HP:0004934)2.12769357
52Increased IgE level (HP:0003212)2.12307252
53Abnormal biliary tract morphology (HP:0012440)2.12246358
54Metaphyseal cupping (HP:0003021)2.11258480
55Symptomatic seizures (HP:0011145)2.11198899
56Testicular neoplasm (HP:0010788)2.10696576
57Hyperglycemia (HP:0003074)2.10503083
58Recurrent viral infections (HP:0004429)2.09721573
59Milia (HP:0001056)2.09476808
60Chronic sinusitis (HP:0011109)2.09412286
61Tongue fasciculations (HP:0001308)2.08731408
62Amyloidosis (HP:0011034)2.08545176
63Short nail (HP:0001799)2.08312700
64Hypoplasia of the thymus (HP:0000778)2.07734614
65Erythema (HP:0010783)2.07032695
66Alveolar cell carcinoma (HP:0006519)2.06714534
67Plantar hyperkeratosis (HP:0007556)2.06514206
68Submucous cleft hard palate (HP:0000176)2.06492687
69Basal ganglia calcification (HP:0002135)2.06094603
70Hypoplasia of the odontoid process (HP:0003311)2.05782525
71Stomatitis (HP:0010280)2.05091477
72Myocardial infarction (HP:0001658)2.04783945
73EMG: myopathic abnormalities (HP:0003458)2.04735100
74Keratoconjunctivitis sicca (HP:0001097)2.03500671
75Palmoplantar hyperkeratosis (HP:0000972)2.01290958
76Gastrointestinal atresia (HP:0002589)1.99630833
77Right ventricular cardiomyopathy (HP:0011663)1.99405388
78Abnormality of pyrimidine metabolism (HP:0004353)1.97080317
79Abnormal spermatogenesis (HP:0008669)1.96322670
80Abnormality of the anterior horn cell (HP:0006802)1.94782392
81Degeneration of anterior horn cells (HP:0002398)1.94782392
82Xerostomia (HP:0000217)1.94473992
83Systemic lupus erythematosus (HP:0002725)1.94300241
84Congenital, generalized hypertrichosis (HP:0004540)1.94186624
85Increased cerebral lipofuscin (HP:0011813)1.93672985
86Recurrent abscess formation (HP:0002722)1.93671203
87Onycholysis (HP:0001806)1.93637718
88Steatorrhea (HP:0002570)1.93469754
89Increased neuronal autofluorescent lipopigment (HP:0002074)1.93372466
90Muscle fibrillation (HP:0010546)1.93155406
91Recurrent fungal infections (HP:0002841)1.92839682
92Meckel diverticulum (HP:0002245)1.92130703
93Spinal muscular atrophy (HP:0007269)1.92041560
94Autoimmune hemolytic anemia (HP:0001890)1.90704872
95Aplastic anemia (HP:0001915)1.90216279
96Azoospermia (HP:0000027)1.90185274
97Facial diplegia (HP:0001349)1.89996075
98Abnormality of eosinophils (HP:0001879)1.89986177
99Carpal bone hypoplasia (HP:0001498)1.89743680
100Insulin-resistant diabetes mellitus (HP:0000831)1.89709793
101Cardiovascular calcification (HP:0011915)1.89385484
102Abnormality of chromosome stability (HP:0003220)1.89013821
103Decreased skull ossification (HP:0004331)1.88440378
104Intestinal atresia (HP:0011100)1.87873567
105Absent thumb (HP:0009777)1.87795986
106Neoplasm of the tracheobronchial system (HP:0100552)1.87563920
107Vertebral compression fractures (HP:0002953)1.87455667
108Tubulointerstitial nephritis (HP:0001970)1.86456769
109Abnormality of the vasculature of the conjunctiva (HP:0008054)1.85964180
110Urethral obstruction (HP:0000796)1.85865673
111Lip pit (HP:0100267)1.85758856
112Neonatal respiratory distress (HP:0002643)1.84518991
113Palmar hyperkeratosis (HP:0010765)1.84445237
114Distal lower limb amyotrophy (HP:0008944)1.83791234
115Leukocytosis (HP:0001974)1.83731863
116Gonadal dysgenesis (HP:0000133)1.82428452
117Upper motor neuron abnormality (HP:0002127)1.82380630
118Stomach cancer (HP:0012126)1.81754221
119Type 1 muscle fiber predominance (HP:0003803)1.81709846
120Anhidrosis (HP:0000970)1.81549009
121Neck muscle weakness (HP:0000467)1.81333692
122Muscle hypertrophy of the lower extremities (HP:0008968)1.81075799
123Abnormality of skull ossification (HP:0002703)1.80401667
124Atrophic scars (HP:0001075)1.80333680
125Abnormality of the nasal septum (HP:0000419)1.80047589
126Supernumerary spleens (HP:0009799)1.79740586
127Absent frontal sinuses (HP:0002688)1.79271281
128Keratoconjunctivitis (HP:0001096)1.78728238
129Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78237771
130Hypoglycemic seizures (HP:0002173)1.77964490
131Abnormality of the ileum (HP:0001549)1.77653617
132Breast hypoplasia (HP:0003187)1.77278763
133Optic neuritis (HP:0100653)1.77103328
134Retrobulbar optic neuritis (HP:0100654)1.77103328
135Meningitis (HP:0001287)1.76545266
136Syringomyelia (HP:0003396)1.76359856
137Spinal cord lesions (HP:0100561)1.76359856
138Thick nail (HP:0001805)1.75896432
139Barrel-shaped chest (HP:0001552)1.75223433
140Stillbirth (HP:0003826)1.74921861
141Reticulocytopenia (HP:0001896)1.74813805
142Fetal akinesia sequence (HP:0001989)1.74787431
143Mitral stenosis (HP:0001718)1.74565524
144Esophageal varix (HP:0002040)1.74020322
145Hypothermia (HP:0002045)1.73014539
146Constricted visual fields (HP:0001133)1.72544105
147Eczematoid dermatitis (HP:0000976)1.72542721
148Mesomelia (HP:0003027)1.72477553
149Ankle contracture (HP:0006466)1.72220928
150Widely spaced teeth (HP:0000687)1.71890006
151Beaking of vertebral bodies (HP:0004568)1.71636080
152Prostate neoplasm (HP:0100787)1.71380339
153Abnormality of the calf musculature (HP:0001430)1.70967940
154Curly hair (HP:0002212)1.69882537
155Dry hair (HP:0011359)1.69252459
156Amaurosis fugax (HP:0100576)1.69222559
157Esophageal atresia (HP:0002032)1.68907748
158Microvesicular hepatic steatosis (HP:0001414)1.68360447
159Menstrual irregularities (HP:0000858)1.67442039
160Spondylolisthesis (HP:0003302)1.67129629
161Tetraparesis (HP:0002273)1.65953790
162Small intestinal stenosis (HP:0012848)1.65887632
163Duodenal stenosis (HP:0100867)1.65887632
164Trismus (HP:0000211)1.65745035
165Deep philtrum (HP:0002002)1.65548218
166Acute myeloid leukemia (HP:0004808)1.65501776
167Growth hormone excess (HP:0000845)1.65417794
168Gowers sign (HP:0003391)1.65407633
169Combined immunodeficiency (HP:0005387)1.65253431
170Exercise-induced muscle cramps (HP:0003710)1.64878008
171Pruritus (HP:0000989)1.64791474
172Reduced subcutaneous adipose tissue (HP:0003758)1.63975738
173Abnormality of liposaccharide metabolism (HP:0010968)1.63624512
174Abnormality of glycosphingolipid metabolism (HP:0004343)1.63624512
175Abnormality of glycolipid metabolism (HP:0010969)1.63624512
176Hematochezia (HP:0002573)1.62838341
177Abnormality of the preputium (HP:0100587)1.62482034
178Glossoptosis (HP:0000162)1.62079806
179Flat capital femoral epiphysis (HP:0003370)1.60923174
180Arterial thrombosis (HP:0004420)1.60830162
181Abnormal hemoglobin (HP:0011902)1.60790909
182Portal hypertension (HP:0001409)1.60720334
183Alopecia of scalp (HP:0002293)1.60673613
184Increased mean platelet volume (HP:0011877)1.60200616
185Abnormality of the duodenum (HP:0002246)1.59918170
186Irregular epiphyses (HP:0010582)1.59274608
187Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.57830484
188Anorexia (HP:0002039)1.57757708
189Abnormality of the calcaneus (HP:0008364)1.57725815
190Abnormality of the frontal sinuses (HP:0002687)1.57590982
191Spontaneous hematomas (HP:0007420)1.57373079

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.44584651
2AKT33.29768576
3ZAK2.71518419
4TGFBR22.52413487
5TSSK62.34410335
6MAP3K142.29865082
7BRSK22.26337671
8MAP3K22.19651034
9TGFBR12.18476905
10FRK2.16734047
11TIE12.15056976
12ACVR1B2.13736454
13MAP3K32.10032938
14WEE12.01229445
15IRAK12.00559320
16TAOK31.97837523
17TBK11.90354346
18MAP3K121.88409168
19PIM21.86642234
20CDK121.86531742
21MAP3K61.81368737
22MET1.68649187
23PASK1.59174689
24RPS6KB21.56998941
25OBSCN1.55537404
26STK101.53137670
27ERN11.52719360
28STK31.49917405
29PIM11.49694275
30MAP3K131.46454833
31CASK1.45185279
32PDK21.38258849
33IRAK21.34084841
34CDC71.33035906
35CDK81.31910520
36MAP2K31.31592351
37MAP3K71.27455415
38PLK31.25932507
39CHUK1.23164271
40RPS6KA41.21273914
41NLK1.19827005
42MAPK151.19598475
43KDR1.17726651
44MST1R1.16175174
45SIK31.15484856
46MST41.13724189
47TXK1.11318764
48TRPM71.09318126
49BUB11.08999517
50IKBKB1.07392623
51ERBB31.01604197
52HIPK21.00849478
53MAP3K11.00554229
54MAPK70.99768702
55BRD40.99332620
56MAPKAPK30.99301375
57CSF1R0.98131316
58EIF2AK30.97059127
59VRK10.93875082
60CDK70.93212327
61CDK60.92993515
62MAP3K50.92970557
63ERBB40.91347401
64TEC0.89058725
65TTK0.88164441
66MKNK20.87152878
67GRK70.86646785
68CSK0.86270233
69SCYL20.85663931
70IKBKE0.85459338
71FLT30.85282441
72BMPR20.85108911
73NEK20.85065275
74STK240.84550731
75PLK10.83510585
76MAP2K20.80559729
77GRK10.79420996
78MKNK10.79104368
79LATS10.78699475
80CCNB10.76665570
81IRAK40.76632467
82GSK3A0.74223907
83EIF2AK20.73305426
84CDK90.72393068
85PRKG20.72254813
86PIK3CG0.71843964
87NEK90.70586703
88ADRBK20.68751919
89PAK40.68613372
90AURKB0.68247004
91YES10.67824849
92NME20.67637524
93EPHA30.67379256
94PRPF4B0.67108253
95EPHB10.66617855
96EEF2K0.66265667
97TAOK20.65639499
98JAK30.65218862
99MAP4K10.64221021
100TTN0.64153242
101ABL20.64091700
102EIF2AK10.62001477
103KIT0.61967835
104TAF10.61409570
105STK38L0.61207454
106FER0.59708477
107IRAK30.59509980
108PLK20.58223325
109BCR0.57766583
110MYLK0.57311536
111CHEK20.56414376
112STK40.56215186
113MATK0.56156413
114PHKG20.55827104
115PHKG10.55827104
116RPS6KA50.55485600
117JAK10.53057064
118FGFR30.52307399
119ZAP700.50656438
120RPS6KA60.50438131
121BRAF0.48663066
122MAPK120.48344192
123MAPKAPK20.48342960
124BRSK10.47392086
125MAP2K40.46833170
126INSRR0.46464749
127MAPK110.46051945
128SGK20.45440196
129MAP2K60.44691289
130MOS0.44386258
131GRK60.43801298
132ABL10.43413704
133ATR0.42774921
134CLK10.42774897
135MAPK30.42642114
136RPS6KA10.42244651
137MAP2K10.41990428
138ATM0.40928472
139DAPK10.40397403
140PRKAA20.39817646
141MAPK40.38537537
142MAP4K20.38392698
143TYK20.37167426
144HCK0.35580760
145STK390.35240019
146MAPK10.33335588
147TRIM280.30529260

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93944680
2Circadian rhythm_Homo sapiens_hsa047102.71027345
3Mismatch repair_Homo sapiens_hsa034302.65928962
4DNA replication_Homo sapiens_hsa030302.61219792
5Asthma_Homo sapiens_hsa053102.53904642
6Type I diabetes mellitus_Homo sapiens_hsa049402.23479723
7Cell cycle_Homo sapiens_hsa041102.08100428
8Legionellosis_Homo sapiens_hsa051342.03930265
9Allograft rejection_Homo sapiens_hsa053302.01384809
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99449384
11Nucleotide excision repair_Homo sapiens_hsa034201.96162229
12Graft-versus-host disease_Homo sapiens_hsa053321.85572169
13Staphylococcus aureus infection_Homo sapiens_hsa051501.79841918
14Homologous recombination_Homo sapiens_hsa034401.78315890
15p53 signaling pathway_Homo sapiens_hsa041151.77871143
16Base excision repair_Homo sapiens_hsa034101.75900252
17Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.73530837
18Dorso-ventral axis formation_Homo sapiens_hsa043201.73358629
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.72104162
20Thyroid cancer_Homo sapiens_hsa052161.65420311
21Leishmaniasis_Homo sapiens_hsa051401.64614172
22RNA degradation_Homo sapiens_hsa030181.64433551
23Autoimmune thyroid disease_Homo sapiens_hsa053201.62705346
24RNA transport_Homo sapiens_hsa030131.60492276
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.54705320
26Fanconi anemia pathway_Homo sapiens_hsa034601.52755320
27Antigen processing and presentation_Homo sapiens_hsa046121.52111611
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.49197152
29Adherens junction_Homo sapiens_hsa045201.47879167
30Regulation of autophagy_Homo sapiens_hsa041401.44491869
31Protein export_Homo sapiens_hsa030601.42447467
32Complement and coagulation cascades_Homo sapiens_hsa046101.37195216
33Spliceosome_Homo sapiens_hsa030401.35365680
34RNA polymerase_Homo sapiens_hsa030201.34329621
35Other glycan degradation_Homo sapiens_hsa005111.34302494
36Selenocompound metabolism_Homo sapiens_hsa004501.33857671
37B cell receptor signaling pathway_Homo sapiens_hsa046621.33507661
38Pertussis_Homo sapiens_hsa051331.32703179
39Fatty acid elongation_Homo sapiens_hsa000621.32586032
40Basal transcription factors_Homo sapiens_hsa030221.32200437
41One carbon pool by folate_Homo sapiens_hsa006701.30473589
42Caffeine metabolism_Homo sapiens_hsa002321.28528781
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.26965319
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22621740
45Non-homologous end-joining_Homo sapiens_hsa034501.22546213
46Herpes simplex infection_Homo sapiens_hsa051681.17782322
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17688413
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17246818
49Ribosome_Homo sapiens_hsa030101.16557717
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.14587222
51Viral carcinogenesis_Homo sapiens_hsa052031.13624079
52Systemic lupus erythematosus_Homo sapiens_hsa053221.12705946
53Proteasome_Homo sapiens_hsa030501.12531189
54Sulfur metabolism_Homo sapiens_hsa009201.10771423
55Shigellosis_Homo sapiens_hsa051311.09446599
56Apoptosis_Homo sapiens_hsa042101.08249467
57Leukocyte transendothelial migration_Homo sapiens_hsa046701.07947550
58Malaria_Homo sapiens_hsa051441.07382085
59Insulin resistance_Homo sapiens_hsa049311.06537618
60Pyrimidine metabolism_Homo sapiens_hsa002401.05031170
61Primary immunodeficiency_Homo sapiens_hsa053401.03237880
62Viral myocarditis_Homo sapiens_hsa054161.01566013
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98542511
64Epstein-Barr virus infection_Homo sapiens_hsa051690.98048178
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97168762
66TGF-beta signaling pathway_Homo sapiens_hsa043500.96929373
67Galactose metabolism_Homo sapiens_hsa000520.96727680
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96271943
69Influenza A_Homo sapiens_hsa051640.95863385
70Platelet activation_Homo sapiens_hsa046110.95036276
71Toxoplasmosis_Homo sapiens_hsa051450.93479664
72HTLV-I infection_Homo sapiens_hsa051660.92686463
73Arachidonic acid metabolism_Homo sapiens_hsa005900.89627606
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.89591002
75Rheumatoid arthritis_Homo sapiens_hsa053230.89330288
76Hepatitis B_Homo sapiens_hsa051610.89286829
77Phagosome_Homo sapiens_hsa041450.88847617
78Small cell lung cancer_Homo sapiens_hsa052220.88500494
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88290118
80Hematopoietic cell lineage_Homo sapiens_hsa046400.87976265
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86056080
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85114190
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.85024908
84ECM-receptor interaction_Homo sapiens_hsa045120.84151062
85Chronic myeloid leukemia_Homo sapiens_hsa052200.83455015
86Measles_Homo sapiens_hsa051620.83299931
87Osteoclast differentiation_Homo sapiens_hsa043800.82091509
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79078423
89MicroRNAs in cancer_Homo sapiens_hsa052060.77864918
90Folate biosynthesis_Homo sapiens_hsa007900.74550577
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.73364414
92Tuberculosis_Homo sapiens_hsa051520.72971171
93Sphingolipid metabolism_Homo sapiens_hsa006000.72529266
94Bladder cancer_Homo sapiens_hsa052190.71364949
95TNF signaling pathway_Homo sapiens_hsa046680.70298716
96Prolactin signaling pathway_Homo sapiens_hsa049170.70153041
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69236509
98Notch signaling pathway_Homo sapiens_hsa043300.68460287
99mTOR signaling pathway_Homo sapiens_hsa041500.68323175
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67689794
101Hepatitis C_Homo sapiens_hsa051600.64960071
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.63057780
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63049662
104Focal adhesion_Homo sapiens_hsa045100.62653808
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61188745
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61009820
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60583157
108Prostate cancer_Homo sapiens_hsa052150.59991495
109Renal cell carcinoma_Homo sapiens_hsa052110.59772816
110Pentose phosphate pathway_Homo sapiens_hsa000300.58951969
111FoxO signaling pathway_Homo sapiens_hsa040680.58356382
112Purine metabolism_Homo sapiens_hsa002300.57589746
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57501073
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57388959
115Chemical carcinogenesis_Homo sapiens_hsa052040.57122660
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.56836682
117HIF-1 signaling pathway_Homo sapiens_hsa040660.56772889
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56726906
119Salmonella infection_Homo sapiens_hsa051320.56590471
120Proteoglycans in cancer_Homo sapiens_hsa052050.55935724
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55035668
122Long-term depression_Homo sapiens_hsa047300.54968759
123Type II diabetes mellitus_Homo sapiens_hsa049300.52700096
124Pathways in cancer_Homo sapiens_hsa052000.50510970
125Pancreatic cancer_Homo sapiens_hsa052120.50174017
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.49266349
127Amoebiasis_Homo sapiens_hsa051460.48680108
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48390962
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47828655
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47761011
131Lysosome_Homo sapiens_hsa041420.47391095
132MAPK signaling pathway_Homo sapiens_hsa040100.46774427
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46523861
134Insulin signaling pathway_Homo sapiens_hsa049100.45327530
135Acute myeloid leukemia_Homo sapiens_hsa052210.43817413
136Inositol phosphate metabolism_Homo sapiens_hsa005620.43467153
137African trypanosomiasis_Homo sapiens_hsa051430.42704790
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41492509
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36826964
140Nitrogen metabolism_Homo sapiens_hsa009100.36304430
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.34903913

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