KLC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in sensory perception (GO:0050962)8.33447467
2detection of light stimulus involved in visual perception (GO:0050908)8.33447467
3keratinization (GO:0031424)7.40406367
4establishment of skin barrier (GO:0061436)7.27968548
5molting cycle (GO:0042303)6.94104869
6hair cycle (GO:0042633)6.94104869
7regulation of water loss via skin (GO:0033561)6.82723799
8hemidesmosome assembly (GO:0031581)6.65403456
9retinal rod cell development (GO:0046548)6.62230363
10photoreceptor cell maintenance (GO:0045494)5.43198658
11rhodopsin mediated signaling pathway (GO:0016056)5.26587405
12photoreceptor cell development (GO:0042461)5.14833561
13peptide cross-linking (GO:0018149)5.06594608
14keratinocyte differentiation (GO:0030216)5.04920752
15retinal cone cell development (GO:0046549)5.03448582
16response to pheromone (GO:0019236)4.96079144
17regulation of rhodopsin mediated signaling pathway (GO:0022400)4.87826188
18multicellular organismal water homeostasis (GO:0050891)4.83409215
19eye photoreceptor cell development (GO:0042462)4.80332972
20behavioral response to nicotine (GO:0035095)4.75275304
21GMP metabolic process (GO:0046037)4.55492889
22positive regulation of gastrulation (GO:2000543)4.54360929
23fucose catabolic process (GO:0019317)4.50870479
24L-fucose metabolic process (GO:0042354)4.50870479
25L-fucose catabolic process (GO:0042355)4.50870479
26epidermal cell differentiation (GO:0009913)4.47382980
27ectoderm development (GO:0007398)4.44485232
28photoreceptor cell differentiation (GO:0046530)4.22456573
29eye photoreceptor cell differentiation (GO:0001754)4.22456573
30DNA deamination (GO:0045006)4.20678303
31keratinocyte development (GO:0003334)4.19780241
32keratinocyte proliferation (GO:0043616)4.10094537
33bundle of His cell to Purkinje myocyte communication (GO:0086069)4.06384239
34preassembly of GPI anchor in ER membrane (GO:0016254)4.04894005
35potassium ion homeostasis (GO:0055075)4.03931201
36sensory perception of light stimulus (GO:0050953)4.02392237
37visual perception (GO:0007601)4.02123162
38retina development in camera-type eye (GO:0060041)3.99114814
39cellular potassium ion homeostasis (GO:0030007)3.95055055
40detection of light stimulus (GO:0009583)3.89996122
41detection of visible light (GO:0009584)3.84984009
42regulation of ruffle assembly (GO:1900027)3.76535033
43epidermis development (GO:0008544)3.71330501
44protein complex biogenesis (GO:0070271)3.70317520
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.69403809
46NADH dehydrogenase complex assembly (GO:0010257)3.69403809
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.69403809
48water homeostasis (GO:0030104)3.68994248
49negative regulation of cytosolic calcium ion concentration (GO:0051481)3.63618158
50Golgi transport vesicle coating (GO:0048200)3.58556617
51COPI coating of Golgi vesicle (GO:0048205)3.58556617
52interferon-gamma secretion (GO:0072643)3.54355585
53platelet dense granule organization (GO:0060155)3.52026523
54piRNA metabolic process (GO:0034587)3.49904108
55cardiac right ventricle morphogenesis (GO:0003215)3.48788793
56glandular epithelial cell differentiation (GO:0002067)3.48559443
57negative regulation of telomere maintenance (GO:0032205)3.48402212
58water-soluble vitamin biosynthetic process (GO:0042364)3.45231692
59epithelial cell fate commitment (GO:0072148)3.43512323
60pyrimidine dimer repair (GO:0006290)3.42146313
61mitochondrial respiratory chain complex assembly (GO:0033108)3.41963933
62phosphatidylinositol acyl-chain remodeling (GO:0036149)3.41296498
63epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.38019192
64cellular ketone body metabolic process (GO:0046950)3.37685621
65urinary tract smooth muscle contraction (GO:0014848)3.36438286
66respiratory chain complex IV assembly (GO:0008535)3.35476700
67intermediate filament organization (GO:0045109)3.34948215
68indolalkylamine metabolic process (GO:0006586)3.33687529
69phototransduction (GO:0007602)3.32463117
70mannosylation (GO:0097502)3.32397398
71sensory perception of smell (GO:0007608)3.31446875
72protein polyglutamylation (GO:0018095)3.26826087
73regulation of hexokinase activity (GO:1903299)3.23809801
74regulation of glucokinase activity (GO:0033131)3.23809801
75kynurenine metabolic process (GO:0070189)3.23226178
76phototransduction, visible light (GO:0007603)3.18423619
77viral transcription (GO:0019083)3.18423279
78regulation of secondary heart field cardioblast proliferation (GO:0003266)3.18096998
79regulation of cardioblast proliferation (GO:0003264)3.18096998
80detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.17895371
81regulation of cilium movement (GO:0003352)3.17848883
82GPI anchor metabolic process (GO:0006505)3.17774553
83ketone body metabolic process (GO:1902224)3.17492945
84sphingosine metabolic process (GO:0006670)3.13603338
85planar cell polarity pathway involved in neural tube closure (GO:0090179)3.12972765
86S-adenosylmethionine metabolic process (GO:0046500)3.10648576
87tryptophan catabolic process (GO:0006569)3.08066323
88indole-containing compound catabolic process (GO:0042436)3.08066323
89indolalkylamine catabolic process (GO:0046218)3.08066323
90sphingoid metabolic process (GO:0046519)3.07649781
91cornea development in camera-type eye (GO:0061303)3.07183042
92protein-cofactor linkage (GO:0018065)3.04960180
93peptidyl-histidine modification (GO:0018202)3.04005704
94hair cell differentiation (GO:0035315)3.03388356
95regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.02499255
96endocardial cushion morphogenesis (GO:0003203)3.02015948
97negative regulation of keratinocyte proliferation (GO:0010839)3.01683233
98sensory perception of chemical stimulus (GO:0007606)3.01395468
99DNA methylation involved in gamete generation (GO:0043046)3.01094232
100cytochrome complex assembly (GO:0017004)3.00150271
101translational termination (GO:0006415)2.97892687
102axoneme assembly (GO:0035082)2.93490698
103epithelial cilium movement (GO:0003351)2.92738931
104rRNA catabolic process (GO:0016075)2.92538334
105phosphatidylserine acyl-chain remodeling (GO:0036150)2.91348590
106L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.90701359
107skin morphogenesis (GO:0043589)2.90609895
108tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.90220680
109RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.90220680
110negative regulation of mast cell activation (GO:0033004)2.89499957
111sensory perception of taste (GO:0050909)2.89152674
112regulation of nuclear cell cycle DNA replication (GO:0033262)2.88820201
113tryptophan metabolic process (GO:0006568)2.87098273
114positive regulation of synapse maturation (GO:0090129)2.86978965
115regulation of transforming growth factor beta2 production (GO:0032909)2.86213411
116phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.85553009
117GPI anchor biosynthetic process (GO:0006506)2.85104887
118diol metabolic process (GO:0034311)2.84220745
119auditory receptor cell stereocilium organization (GO:0060088)2.83880604
120somite rostral/caudal axis specification (GO:0032525)2.82652474
121cellular response to light stimulus (GO:0071482)2.82182329
122protein K6-linked ubiquitination (GO:0085020)2.81885985
123protein neddylation (GO:0045116)2.81626347
124cilium morphogenesis (GO:0060271)2.81093721
125negative regulation of cell fate specification (GO:0009996)2.80213400
126mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.79668508
127positive regulation of vesicle fusion (GO:0031340)2.79184218
128SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.76022737
129C-terminal protein lipidation (GO:0006501)2.74569252
130protein-chromophore linkage (GO:0018298)2.74251079
131pseudouridine synthesis (GO:0001522)2.74209655
132energy coupled proton transport, down electrochemical gradient (GO:0015985)2.72689898
133ATP synthesis coupled proton transport (GO:0015986)2.72689898
134gland morphogenesis (GO:0022612)2.71567769
135replication fork processing (GO:0031297)2.71087889
136regulation of type B pancreatic cell apoptotic process (GO:2000674)2.69969325
137protein targeting to ER (GO:0045047)2.68606828
138protein K11-linked deubiquitination (GO:0035871)2.67727863
139nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67207010
140regulation of action potential (GO:0098900)2.66712786
141cotranslational protein targeting to membrane (GO:0006613)2.66460998
142detection of external stimulus (GO:0009581)2.65425951
143C-terminal protein amino acid modification (GO:0018410)2.64615034
144detection of abiotic stimulus (GO:0009582)2.62051383
145establishment of epithelial cell polarity (GO:0090162)2.61541557
146potassium ion export (GO:0071435)2.61424165
147tRNA processing (GO:0008033)2.61295203
148pharyngeal system development (GO:0060037)2.60529680
149exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.60161832
150establishment of protein localization to endoplasmic reticulum (GO:0072599)2.60146944
151translational elongation (GO:0006414)2.59395717
152G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.58445473
153nonmotile primary cilium assembly (GO:0035058)2.56679858
154amine catabolic process (GO:0009310)2.56535916
155cellular biogenic amine catabolic process (GO:0042402)2.56535916
156male meiosis I (GO:0007141)2.56124045
157positive regulation of prostaglandin secretion (GO:0032308)2.54691138
158startle response (GO:0001964)2.53527239
159reflex (GO:0060004)2.53015355
160negative regulation of glycoprotein biosynthetic process (GO:0010561)2.52696071
161establishment of protein localization to mitochondrial membrane (GO:0090151)2.51882784
162adaptation of signaling pathway (GO:0023058)2.51789247
163multicellular organism reproduction (GO:0032504)2.51585129
164neural tube formation (GO:0001841)2.51189332
165regulation of chromatin binding (GO:0035561)2.50746387
166cilium organization (GO:0044782)2.49302733
167L-methionine salvage (GO:0071267)2.48688706
168L-methionine biosynthetic process (GO:0071265)2.48688706
169amino acid salvage (GO:0043102)2.48688706
170reciprocal meiotic recombination (GO:0007131)2.47737659
171reciprocal DNA recombination (GO:0035825)2.47737659
172intestinal epithelial cell development (GO:0060576)2.47180720
173viral life cycle (GO:0019058)2.47119104
174maturation of SSU-rRNA (GO:0030490)2.46247989
175recombinational repair (GO:0000725)2.45811248
176tRNA modification (GO:0006400)2.45791313
177regulation of telomere maintenance (GO:0032204)2.44984687
178protein localization to endoplasmic reticulum (GO:0070972)2.43369759
179ribosomal small subunit biogenesis (GO:0042274)2.42950267
180glucosamine-containing compound catabolic process (GO:1901072)2.41652975
181cellular protein complex disassembly (GO:0043624)2.41056255
182regulation of keratinocyte proliferation (GO:0010837)2.39464758
183mesenchyme morphogenesis (GO:0072132)2.38304776
184regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.37584381
185protein complex disassembly (GO:0043241)2.37343205
186desmosome organization (GO:0002934)10.0728247

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.29885977
2ZNF274_21170338_ChIP-Seq_K562_Hela4.26116468
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.38951846
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.20306289
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.08846868
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.73769602
7ZNF263_19887448_ChIP-Seq_K562_Human2.71084253
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51474929
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.50756943
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.44783741
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44209974
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.42455442
13SOX9_24532713_ChIP-Seq_HFSC_Mouse2.37385057
14IGF1R_20145208_ChIP-Seq_DFB_Human2.34679273
15P63_26484246_Chip-Seq_KERATINOCYTES_Human2.20033354
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15540673
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15212717
18FUS_26573619_Chip-Seq_HEK293_Human2.10416798
19GBX2_23144817_ChIP-Seq_PC3_Human2.09622164
20ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.09348390
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05553445
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.03980187
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03035910
24EWS_26573619_Chip-Seq_HEK293_Human2.02892428
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02396946
26TP63_17297297_ChIP-ChIP_HaCaT_Human12.0914468
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.98954304
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97827112
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.97645199
30YY1_22570637_ChIP-Seq_MALME-3M_Human1.94382422
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.91527000
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.89820051
33TAF15_26573619_Chip-Seq_HEK293_Human1.88170198
34* LXR_22292898_ChIP-Seq_THP-1_Human1.81895932
35ER_23166858_ChIP-Seq_MCF-7_Human1.79594361
36CTCF_20526341_ChIP-Seq_ESCs_Human1.79321088
37MYC_18940864_ChIP-ChIP_HL60_Human1.73248294
38TP53_22573176_ChIP-Seq_HFKS_Human1.68813060
39TP63_22573176_ChIP-Seq_HFKS_Human1.65915215
40RACK7_27058665_Chip-Seq_MCF-7_Human1.65436380
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.64525598
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.64293174
43CTCF_27219007_Chip-Seq_Bcells_Human1.64281076
44P68_20966046_ChIP-Seq_HELA_Human1.63285824
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.62247733
46P300_19829295_ChIP-Seq_ESCs_Human1.60979983
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59958091
48VDR_23849224_ChIP-Seq_CD4+_Human1.59941550
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59210456
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.58467232
51* FOXA1_25329375_ChIP-Seq_VCAP_Human1.54762481
52* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.54762481
53EZH2_22144423_ChIP-Seq_EOC_Human1.48794567
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48656690
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.48307584
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.47707195
57PHF8_20622854_ChIP-Seq_HELA_Human1.47388384
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.47154622
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46756633
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46314277
61AR_20517297_ChIP-Seq_VCAP_Human1.46157974
62IRF1_19129219_ChIP-ChIP_H3396_Human1.45723034
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.45644407
64NCOR_22424771_ChIP-Seq_293T_Human1.43079937
65BCAT_22108803_ChIP-Seq_LS180_Human1.42687856
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41354245
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41146225
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40664516
69ATF3_27146783_Chip-Seq_COLON_Human1.39115291
70CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.36684433
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.36245153
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.36117700
73MYC_22102868_ChIP-Seq_BL_Human1.34787676
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34726303
75CBP_20019798_ChIP-Seq_JUKART_Human1.34726303
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33565674
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32537653
78ELK1_19687146_ChIP-ChIP_HELA_Human1.32460178
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32008327
80VDR_22108803_ChIP-Seq_LS180_Human1.31161370
81HOXB7_26014856_ChIP-Seq_BT474_Human1.30219705
82E2F1_20622854_ChIP-Seq_HELA_Human1.29837853
83UBF1/2_26484160_Chip-Seq_HMECs_Human1.28675281
84SMC4_20622854_ChIP-Seq_HELA_Human1.28529766
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27548722
86ERA_21632823_ChIP-Seq_H3396_Human1.27374131
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26881439
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25881596
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25687231
90KDM2B_26808549_Chip-Seq_K562_Human1.24776011
91* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24116666
92SOX2_19829295_ChIP-Seq_ESCs_Human1.22753009
93NANOG_19829295_ChIP-Seq_ESCs_Human1.22753009
94TCF4_22108803_ChIP-Seq_LS180_Human1.22468912
95EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21797518
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21640131
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.21378659
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20724062
99* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20620810
100MYC_19829295_ChIP-Seq_ESCs_Human1.20140533
101KDM2B_26808549_Chip-Seq_DND41_Human1.20031568
102* TAF2_19829295_ChIP-Seq_ESCs_Human1.19159935
103AR_25329375_ChIP-Seq_VCAP_Human1.18909687
104CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18533397
105VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17092741
106REST_21632747_ChIP-Seq_MESCs_Mouse1.17060859
107TCF4_23295773_ChIP-Seq_U87_Human1.16204983
108BCOR_27268052_Chip-Seq_Bcells_Human1.16204457
109TRIM28_21343339_ChIP-Seq_HEK293_Human1.15991098
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15352744
111CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15214114
112KLF5_25053715_ChIP-Seq_YYC3_Human1.14292269
113BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12219443
114* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12192610
115STAT3_23295773_ChIP-Seq_U87_Human1.11941923
116FOXP3_21729870_ChIP-Seq_TREG_Human1.11168261
117CREB1_26743006_Chip-Seq_LNCaP_Human1.11100776
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09906439
119ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09902755
120KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09036956
121NANOG_20526341_ChIP-Seq_ESCs_Human1.08859644
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08636782
123TP53_20018659_ChIP-ChIP_R1E_Mouse1.08188888
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08072687
125* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08030215
126SMAD4_21799915_ChIP-Seq_A2780_Human1.07584679
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07402046
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07165796
129NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06978059
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06477602
131NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06164497
132CBX2_27304074_Chip-Seq_ESCs_Mouse1.06040474
133RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05206268
134FOXH1_21741376_ChIP-Seq_EPCs_Human1.05028191
135TP63_19390658_ChIP-ChIP_HaCaT_Human1.04780366
136SA1_27219007_Chip-Seq_Bcells_Human1.04253981
137PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03367963
138OCT4_20526341_ChIP-Seq_ESCs_Human1.03337803
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03081878
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03081878
141RBPJ_21746931_ChIP-Seq_IB4_Human1.02641063
142SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02170428
143ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00716774
144GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00577739
145GATA6_21074721_ChIP-Seq_CACO-2_Human1.00433297
146GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99988216
147SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99889604
148EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99649138
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.99016179
150PHF8_20622853_ChIP-Seq_HELA_Human0.98662633
151RUNX2_22187159_ChIP-Seq_PCA_Human0.97385022
152PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97359173
153OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96557044
154* EZH2_27294783_Chip-Seq_ESCs_Mouse0.96060531
155* KDM2B_26808549_Chip-Seq_JURKAT_Human0.96046496
156P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.95585268
157* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95027620
158KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94925127
159P53_21459846_ChIP-Seq_SAOS-2_Human0.94065991
160* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92900661
161* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92900661
162GATA6_25053715_ChIP-Seq_YYC3_Human0.92408666
163CLOCK_20551151_ChIP-Seq_293T_Human0.92392346
164TCF7_22412390_ChIP-Seq_EML_Mouse0.89924739
165SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89003135
166BCL6_27268052_Chip-Seq_Bcells_Human0.88995655
167SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88660489
168RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88581519
169ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87550426
170MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86192913
171MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86007915
172DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85928731
173FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85900603
174NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.85339146
175ERG_20517297_ChIP-Seq_VCAP_Human0.84918146
176GATA3_24758297_ChIP-Seq_MCF-7_Human0.84791689
177* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84661087
178ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84326291
179PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83263104
180EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.82780575
181CHD1_26751641_Chip-Seq_LNCaP_Human0.82243177
182SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81509186
183SMAD4_21741376_ChIP-Seq_ESCs_Human0.81387416
184TP53_23651856_ChIP-Seq_MEFs_Mouse0.80861760
185ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80825490
186KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79603168
187CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79378917
188FOXO3_23340844_ChIP-Seq_DLD1_Human0.77865143
189GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.77291060
190KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77226281
191CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.75683896
192FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.75438785
193TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75429975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.04660700
2MP0002796_impaired_skin_barrier4.60982139
3MP0005551_abnormal_eye_electrophysiolog4.20761014
4MP0006072_abnormal_retinal_apoptosis3.97848605
5MP0003011_delayed_dark_adaptation3.84433658
6MP0005275_abnormal_skin_tensile3.64037307
7MP0005501_abnormal_skin_physiology3.10111720
8MP0008789_abnormal_olfactory_epithelium3.01967522
9MP0000579_abnormal_nail_morphology2.97357483
10MP0005253_abnormal_eye_physiology2.79767942
11MP0003941_abnormal_skin_development2.78549578
12MP0001984_abnormal_olfaction2.75799195
13MP0010030_abnormal_orbit_morphology2.63926220
14MP0002234_abnormal_pharynx_morphology2.61901694
15MP0002098_abnormal_vibrissa_morphology2.60971357
16MP0005394_taste/olfaction_phenotype2.55023265
17MP0005499_abnormal_olfactory_system2.55023265
18MP0002060_abnormal_skin_morphology2.36515524
19MP0008877_abnormal_DNA_methylation2.31611507
20MP0003195_calcinosis2.29450989
21MP0002102_abnormal_ear_morphology2.18169641
22MP0001216_abnormal_epidermal_layer2.14390350
23MP0001986_abnormal_taste_sensitivity2.12789183
24MP0004043_abnormal_pH_regulation2.12474055
25MP0000566_synostosis2.11429797
26MP0003787_abnormal_imprinting2.10116557
27MP0004381_abnormal_hair_follicle2.09590257
28MP0001968_abnormal_touch/_nociception2.05511019
29MP0002163_abnormal_gland_morphology2.05420543
30MP0002837_dystrophic_cardiac_calcinosis2.05218456
31MP0005075_abnormal_melanosome_morpholog2.03944398
32MP0005174_abnormal_tail_pigmentation2.02900903
33MP0000377_abnormal_hair_follicle1.98408065
34MP0000762_abnormal_tongue_morphology1.98230860
35MP0000372_irregular_coat_pigmentation1.97018860
36MP0000647_abnormal_sebaceous_gland1.94077779
37MP0002090_abnormal_vision1.87995370
38MP0010678_abnormal_skin_adnexa1.83030834
39MP0005195_abnormal_posterior_eye1.81078007
40MP0010771_integument_phenotype1.77673312
41MP0000427_abnormal_hair_cycle1.76955000
42MP0002095_abnormal_skin_pigmentation1.74449657
43MP0005379_endocrine/exocrine_gland_phen1.73189134
44MP0003705_abnormal_hypodermis_morpholog1.70198436
45MP0004147_increased_porphyrin_level1.69816523
46MP0000467_abnormal_esophagus_morphology1.68933740
47MP0003453_abnormal_keratinocyte_physiol1.68849318
48MP0002653_abnormal_ependyma_morphology1.68508971
49MP0003136_yellow_coat_color1.68398104
50MP0008872_abnormal_physiological_respon1.67501233
51MP0004142_abnormal_muscle_tone1.66945922
52MP0005391_vision/eye_phenotype1.64009548
53MP0000383_abnormal_hair_follicle1.63375790
54MP0002736_abnormal_nociception_after1.63115240
55MP0000569_abnormal_digit_pigmentation1.61585846
56MP0008058_abnormal_DNA_repair1.59032881
57MP0003878_abnormal_ear_physiology1.58801509
58MP0005377_hearing/vestibular/ear_phenot1.58801509
59MP0000015_abnormal_ear_pigmentation1.54574824
60MP0005646_abnormal_pituitary_gland1.54551138
61MP0001188_hyperpigmentation1.54513694
62MP0008875_abnormal_xenobiotic_pharmacok1.53882294
63MP0009046_muscle_twitch1.52949456
64MP0002877_abnormal_melanocyte_morpholog1.46983848
65MP0001346_abnormal_lacrimal_gland1.46968373
66MP0004233_abnormal_muscle_weight1.46196431
67MP0002876_abnormal_thyroid_physiology1.44001994
68MP0001529_abnormal_vocalization1.43160368
69MP0002928_abnormal_bile_duct1.41979421
70MP0005084_abnormal_gallbladder_morpholo1.41485940
71MP0009745_abnormal_behavioral_response1.40290462
72MP0005645_abnormal_hypothalamus_physiol1.37074989
73MP0004133_heterotaxia1.36527863
74MP0002254_reproductive_system_inflammat1.35535439
75MP0001324_abnormal_eye_pigmentation1.33144663
76MP0002638_abnormal_pupillary_reflex1.32908394
77MP0001849_ear_inflammation1.31726298
78MP0006292_abnormal_olfactory_placode1.30802886
79MP0002938_white_spotting1.30325371
80MP0003786_premature_aging1.29392257
81MP0000013_abnormal_adipose_tissue1.27333462
82MP0003566_abnormal_cell_adhesion1.22027088
83MP0005076_abnormal_cell_differentiation1.20525864
84MP0004947_skin_inflammation1.20409843
85MP0003646_muscle_fatigue1.16799224
86MP0010386_abnormal_urinary_bladder1.16690384
87MP0005389_reproductive_system_phenotype1.15602771
88MP0005220_abnormal_exocrine_pancreas1.15550404
89MP0010352_gastrointestinal_tract_polyps1.14645313
90MP0003718_maternal_effect1.14323608
91MP0003950_abnormal_plasma_membrane1.13601299
92MP0001919_abnormal_reproductive_system1.11277097
93MP0002272_abnormal_nervous_system1.10733234
94MP0005248_abnormal_Harderian_gland1.09186866
95MP0001764_abnormal_homeostasis1.08855715
96MP0001502_abnormal_circadian_rhythm1.07827192
97MP0002233_abnormal_nose_morphology1.07643874
98MP0005083_abnormal_biliary_tract1.06396887
99MP0000003_abnormal_adipose_tissue1.03425630
100MP0001486_abnormal_startle_reflex1.02889182
101MP0006276_abnormal_autonomic_nervous1.02655756
102MP0002160_abnormal_reproductive_system1.01345839
103MP0001501_abnormal_sleep_pattern1.00959869
104MP0000537_abnormal_urethra_morphology1.00939019
105MP0005257_abnormal_intraocular_pressure1.00550800
106MP0009931_abnormal_skin_appearance1.00317095
107MP0002138_abnormal_hepatobiliary_system0.99600684
108MP0005423_abnormal_somatic_nervous0.98756953
109MP0004782_abnormal_surfactant_physiolog0.97260089
110MP0000367_abnormal_coat/_hair0.97100389
111MP0003806_abnormal_nucleotide_metabolis0.97009708
112MP0001243_abnormal_dermal_layer0.93499212
113MP0003763_abnormal_thymus_physiology0.93431100
114MP0000678_abnormal_parathyroid_gland0.92550187
115MP0004264_abnormal_extraembryonic_tissu0.92091383
116MP0001905_abnormal_dopamine_level0.90882487
117MP0002557_abnormal_social/conspecific_i0.90489336
118MP0004742_abnormal_vestibular_system0.90268582
119MP0003121_genomic_imprinting0.89783424
120MP0002752_abnormal_somatic_nervous0.89737219
121MP0005386_behavior/neurological_phenoty0.88595212
122MP0004924_abnormal_behavior0.88595212
123MP0000428_abnormal_craniofacial_morphol0.88331824
124MP0002697_abnormal_eye_size0.87994858
125MP0002572_abnormal_emotion/affect_behav0.87392027
126MP0005410_abnormal_fertilization0.86813255
127MP0002210_abnormal_sex_determination0.85833688
128MP0003698_abnormal_male_reproductive0.85563338
129MP0002909_abnormal_adrenal_gland0.84588601
130MP0003252_abnormal_bile_duct0.83333900
131MP0006035_abnormal_mitochondrial_morpho0.81979588
132MP0002693_abnormal_pancreas_physiology0.80304364
133MP0005670_abnormal_white_adipose0.80071267
134MP0001286_abnormal_eye_development0.79708985
135MP0003890_abnormal_embryonic-extraembry0.78970074
136MP0001191_abnormal_skin_condition0.78257257
137MP0005332_abnormal_amino_acid0.78002367
138MP0001970_abnormal_pain_threshold0.77530397
139MP0001944_abnormal_pancreas_morphology0.77327107
140MP0001293_anophthalmia0.77172439
141MP0000538_abnormal_urinary_bladder0.76250728
142MP0008995_early_reproductive_senescence0.76070235
143MP0003119_abnormal_digestive_system0.74058322
144MP0008961_abnormal_basal_metabolism0.73778920
145MP0001340_abnormal_eyelid_morphology0.73644556
146MP0003755_abnormal_palate_morphology0.70537092
147MP0002277_abnormal_respiratory_mucosa0.68911693
148MP0004019_abnormal_vitamin_homeostasis0.68775325
149MP0002009_preneoplasia0.67315656
150MP0001881_abnormal_mammary_gland0.67115374
151MP0000465_gastrointestinal_hemorrhage0.66097443
152MP0005375_adipose_tissue_phenotype0.64203215
153MP0000049_abnormal_middle_ear0.63241304
154MP0000750_abnormal_muscle_regeneration0.61872790
155MP0002229_neurodegeneration0.60072258
156MP0000627_abnormal_mammary_gland0.59210738
157MP0000462_abnormal_digestive_system0.58943805
158MP0001270_distended_abdomen0.57992186
159MP0005023_abnormal_wound_healing0.57872858
160MP0002282_abnormal_trachea_morphology0.57020460
161MP0003935_abnormal_craniofacial_develop0.54536357
162MP0002092_abnormal_eye_morphology0.53525530
163MP0001851_eye_inflammation0.52091431
164MP0005508_abnormal_skeleton_morphology0.51817445
165MP0004885_abnormal_endolymph0.50369503
166MP0002751_abnormal_autonomic_nervous0.49238754
167MP0000631_abnormal_neuroendocrine_gland0.48226580
168MP0002111_abnormal_tail_morphology0.47769024
169MP0005451_abnormal_body_composition0.46636194

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)9.92438537
2Abnormal rod and cone electroretinograms (HP:0008323)6.65450689
3Absent rod-and cone-mediated responses on ERG (HP:0007688)6.25888362
4Bony spicule pigmentary retinopathy (HP:0007737)5.88555133
5Central scotoma (HP:0000603)5.53782160
6Hypotrichosis (HP:0001006)4.98634624
7Severe visual impairment (HP:0001141)4.85305415
8Abnormality of macular pigmentation (HP:0008002)4.74970182
9Fragile nails (HP:0001808)4.67362560
10Pili torti (HP:0003777)4.55233667
11Pigmentary retinal degeneration (HP:0001146)4.51881672
12Milia (HP:0001056)4.48498370
13Onycholysis (HP:0001806)4.48245959
14Pancreatic cysts (HP:0001737)4.33327969
15Woolly hair (HP:0002224)4.26676602
16Increased IgE level (HP:0003212)4.25756912
17Plantar hyperkeratosis (HP:0007556)4.16921878
18Pendular nystagmus (HP:0012043)4.16716178
19Scotoma (HP:0000575)3.99207840
20Decreased central vision (HP:0007663)3.89930869
21Pancreatic fibrosis (HP:0100732)3.87474359
22Lip pit (HP:0100267)3.77595045
23Increased corneal curvature (HP:0100692)3.75505760
24Keratoconus (HP:0000563)3.75505760
25Molar tooth sign on MRI (HP:0002419)3.72050614
26Abnormality of midbrain morphology (HP:0002418)3.72050614
27Abnormality of nail color (HP:0100643)3.69175244
28Posterior subcapsular cataract (HP:0007787)3.68780254
29Abolished electroretinogram (ERG) (HP:0000550)3.63942746
30Chorioretinal atrophy (HP:0000533)3.63350705
31Right ventricular cardiomyopathy (HP:0011663)3.53468987
32Type II diabetes mellitus (HP:0005978)3.47211522
33Attenuation of retinal blood vessels (HP:0007843)3.40443981
34Nephronophthisis (HP:0000090)3.38690414
35Palmoplantar hyperkeratosis (HP:0000972)3.28826362
36Dyschromatopsia (HP:0007641)3.16592892
37Palmar hyperkeratosis (HP:0010765)3.09841275
38Abnormality of the renal cortex (HP:0011035)3.05750604
39Chronic hepatic failure (HP:0100626)3.05722795
40Abnormality of the renal medulla (HP:0100957)2.93627829
41Atrophic scars (HP:0001075)2.93205842
42Medial flaring of the eyebrow (HP:0010747)2.92917758
43Erythema (HP:0010783)2.90508390
44Photophobia (HP:0000613)2.90422920
45Abnormal hair laboratory examination (HP:0003328)2.88372808
46Acute necrotizing encephalopathy (HP:0006965)2.85398711
47Tubular atrophy (HP:0000092)2.85313914
48Type II lissencephaly (HP:0007260)2.80534761
49Macular degeneration (HP:0000608)2.80191897
50Constricted visual fields (HP:0001133)2.78975159
51Abnormal blistering of the skin (HP:0008066)2.77780785
52Mitochondrial inheritance (HP:0001427)2.73000942
53Furrowed tongue (HP:0000221)2.65136179
54Septo-optic dysplasia (HP:0100842)2.63365160
55Increased CSF lactate (HP:0002490)2.63254262
56Nail dystrophy (HP:0008404)2.63015590
57Cystic liver disease (HP:0006706)2.61168146
58Down-sloping shoulders (HP:0200021)2.56269916
59Concave nail (HP:0001598)2.51812666
60Abnormal mitochondria in muscle tissue (HP:0008316)2.51199493
61Polydipsia (HP:0001959)2.48011561
62Abnormal drinking behavior (HP:0030082)2.48011561
63Severe Myopia (HP:0011003)2.47532575
64Acute encephalopathy (HP:0006846)2.43584563
65Progressive macrocephaly (HP:0004481)2.42809226
66Erythroderma (HP:0001019)2.42321531
67Hepatocellular necrosis (HP:0001404)2.41688271
68Subcapsular cataract (HP:0000523)2.41273504
69Congenital ichthyosiform erythroderma (HP:0007431)2.34352984
70Hepatic necrosis (HP:0002605)2.32443194
71Parakeratosis (HP:0001036)2.29779452
72Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.28927952
73Hypoplastic labia majora (HP:0000059)2.26361668
74Aplasia/Hypoplasia of the fovea (HP:0008060)2.25965343
75Hypoplasia of the fovea (HP:0007750)2.25965343
76Natal tooth (HP:0000695)2.24038813
77Congenital hepatic fibrosis (HP:0002612)2.22842466
78Retinitis pigmentosa (HP:0000510)2.22835874
79Gait imbalance (HP:0002141)2.22579474
80Hypohidrosis (HP:0000966)2.21934337
81Abnormal sex determination (HP:0012244)2.21421316
82Sex reversal (HP:0012245)2.21421316
83Renal cortical cysts (HP:0000803)2.20803692
84Advanced eruption of teeth (HP:0006288)2.19789756
85Popliteal pterygium (HP:0009756)2.19169543
86Sclerocornea (HP:0000647)2.18486197
87Abnormal biliary tract physiology (HP:0012439)2.17482514
88Bile duct proliferation (HP:0001408)2.17482514
89Congenital primary aphakia (HP:0007707)2.16425111
90Anencephaly (HP:0002323)2.13986253
91Cone-rod dystrophy (HP:0000548)2.13834552
92Sparse scalp hair (HP:0002209)2.12608133
93Congenital sensorineural hearing impairment (HP:0008527)2.11576582
94Curly hair (HP:0002212)2.10479798
95Amelogenesis imperfecta (HP:0000705)2.09595965
96Nephrogenic diabetes insipidus (HP:0009806)2.07357877
97Vitreoretinal degeneration (HP:0000655)2.07352303
98Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06072996
99Methylmalonic acidemia (HP:0002912)2.05726683
100Polyuria (HP:0000103)2.05437131
101Optic disc pallor (HP:0000543)2.02532754
102Hypodontia (HP:0000668)2.01939347
103Abnormality of the salivary glands (HP:0010286)2.01093154
104Hypoplasia of dental enamel (HP:0006297)2.00117214
105Gaze-evoked nystagmus (HP:0000640)2.00031364
1063-Methylglutaconic aciduria (HP:0003535)1.99265655
107Lipid accumulation in hepatocytes (HP:0006561)1.99041209
108Abnormality of the labia majora (HP:0012881)1.98199428
109Lissencephaly (HP:0001339)1.96088635
110Choroideremia (HP:0001139)1.95674684
111Abnormality of the fovea (HP:0000493)1.95090553
112Aplasia/hypoplasia of the uterus (HP:0008684)1.93942637
113Hyperventilation (HP:0002883)1.93624135
114Chronic bronchitis (HP:0004469)1.92801979
115Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.92697793
116Hypoplasia of the pons (HP:0012110)1.91751378
117Blepharitis (HP:0000498)1.91542310
118Aplasia/Hypoplasia of the tongue (HP:0010295)1.91358444
119Abnormality of the renal collecting system (HP:0004742)1.89852667
120Duplicated collecting system (HP:0000081)1.89009317
121Ketosis (HP:0001946)1.87489859
122Abnormality of the pons (HP:0007361)1.87107419
123Aplasia/Hypoplasia of the spleen (HP:0010451)1.85761215
124Increased serum lactate (HP:0002151)1.85596331
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80939955
126Abnormality of alanine metabolism (HP:0010916)1.80939955
127Hyperalaninemia (HP:0003348)1.80939955
128Hypoalbuminemia (HP:0003073)1.80667893
129Abnormal albumin level (HP:0012116)1.80667893
130Conjunctival hamartoma (HP:0100780)1.80579766
131Ketoacidosis (HP:0001993)1.80549977
132Brittle hair (HP:0002299)1.80448452
133Abnormality of the gastric mucosa (HP:0004295)1.79426670
134Interstitial pulmonary disease (HP:0006530)1.78138075
135Methylmalonic aciduria (HP:0012120)1.77858262
136Aplasia cutis congenita (HP:0001057)1.76731266
137Aplasia/Hypoplasia affecting the retina (HP:0008061)1.76353627
138Sparse eyelashes (HP:0000653)1.76168789
139Male pseudohermaphroditism (HP:0000037)1.75671042
140Increased hepatocellular lipid droplets (HP:0006565)1.75511220
141Inability to walk (HP:0002540)1.74821293
142Postaxial foot polydactyly (HP:0001830)1.73041822
143Aplasia/Hypoplasia of the macula (HP:0008059)1.71884581
144Congenital, generalized hypertrichosis (HP:0004540)1.70962015
145Asplenia (HP:0001746)1.70597608
146Labial hypoplasia (HP:0000066)1.69165561
147Genetic anticipation (HP:0003743)1.68944071
148Fragile skin (HP:0001030)1.68880392
149Pachygyria (HP:0001302)1.67706429
150Retinal dysplasia (HP:0007973)1.67046491
151Cerebral edema (HP:0002181)1.66288329
152Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66140869
153Abnormal protein N-linked glycosylation (HP:0012347)1.66140869
154Abnormal protein glycosylation (HP:0012346)1.66140869
155Abnormal glycosylation (HP:0012345)1.66140869
156Occipital encephalocele (HP:0002085)1.65840567
157Abnormality of DNA repair (HP:0003254)1.65674688
158Ectropion (HP:0000656)1.65585399
159Trismus (HP:0000211)1.65336712
160Hand muscle atrophy (HP:0009130)1.64432926
161Corneal erosion (HP:0200020)1.64270360
162Myopathic facies (HP:0002058)1.63072849
163Pterygium (HP:0001059)1.62828196
164Oral leukoplakia (HP:0002745)1.58005445
165Neoplasm of the heart (HP:0100544)1.56783661
166Ridged nail (HP:0001807)1.56049488
167Thick nail (HP:0001805)1.53904767
168True hermaphroditism (HP:0010459)1.53254621
169Cerebellar dysplasia (HP:0007033)1.52649427
170Hypoplastic female external genitalia (HP:0012815)1.51904840
171Optic nerve hypoplasia (HP:0000609)1.50015592
172Hamartoma of the eye (HP:0010568)1.48313827
173Unilateral renal agenesis (HP:0000122)1.48157468
174Sparse lateral eyebrow (HP:0005338)1.45523690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.47246227
2FRK5.36442658
3EPHA23.97382657
4MAPK153.60696122
5MAPKAPK33.09868709
6MAP4K23.09557648
7ADRBK22.98138858
8RPS6KB22.84943065
9FER2.81162905
10RIPK12.76587539
11PINK12.71239753
12EEF2K2.69015026
13NUAK12.54640369
14STK38L2.47146722
15BMPR1B2.46945197
16ZAK2.36384562
17DYRK1B2.25308139
18MST1R2.16202178
19MAP3K102.13115045
20EPHA32.12755352
21SIK12.07462235
22DYRK32.03647033
23MAPK132.00335396
24TAOK31.96045769
25PASK1.86967008
26ERN11.83950676
27NME11.83311524
28OXSR11.82165646
29RPS6KA41.80955327
30STK391.76728254
31HIPK21.76149538
32GRK11.75891171
33TXK1.71366672
34INSRR1.68790784
35DYRK21.56787468
36ACVR1B1.55590003
37PKN21.46362774
38MAP3K31.41568368
39ADRBK11.41146823
40CDK31.41044133
41TESK11.40234947
42NEK11.40130224
43PTK61.33050874
44PIK3CG1.29075281
45TRIB31.23844944
46BCKDK1.22779027
47DYRK1A1.21409328
48CASK1.21218378
49STK381.21175639
50NEK21.19315309
51TGFBR11.14368460
52PRKD21.13457277
53MAP3K41.12780084
54MAP3K21.12478400
55PRKCI1.08756746
56PRKD31.07963779
57FGFR11.07588053
58ICK1.05938205
59WNK31.05286083
60FGFR41.05111020
61BRSK21.04303252
62VRK11.03097465
63CDK121.01744495
64IRAK20.99695742
65STK30.97990834
66IRAK10.97370572
67PRKCE0.96466482
68IKBKB0.95399680
69CAMKK20.95135607
70PLK20.94877463
71VRK20.94145679
72DAPK20.90817539
73TLK10.90461136
74CSNK1G30.89856887
75MAP2K20.89799128
76PLK40.89505629
77LATS10.88311305
78WEE10.87568672
79PRKCG0.87499696
80TRIM280.85346044
81MAP3K10.85114424
82CSNK1G10.85089773
83CSNK1G20.83343631
84CSNK1A1L0.82669558
85MAP2K70.81279293
86EPHB20.80418317
87RPS6KA50.79803137
88PTK20.76548104
89MET0.76400207
90PTK2B0.76285527
91LRRK20.75175501
92BCR0.74979539
93NLK0.74927143
94PRKG20.74541836
95GRK60.73012819
96MUSK0.72946856
97MARK10.70619202
98CCNB10.67240516
99PHKG10.63678192
100PHKG20.63678192
101ERBB20.63665507
102BRD40.62526464
103MTOR0.62519126
104PRKCQ0.62509219
105CDK60.61441314
106EIF2AK30.60138674
107MAP3K90.60050677
108CAMK2D0.58490698
109CSNK1A10.57110504
110STK110.56878516
111MKNK20.56615197
112MAP3K120.56554793
113MAPKAPK20.55372045
114PLK30.55334072
115MAPKAPK50.51798508
116PKN10.51072567
117PNCK0.50817493
118TAOK20.50320545
119MST40.50095690
120PRKACA0.49769974
121ERBB30.48462388
122CDK190.48435421
123CDK90.46664130
124CHUK0.46379171
125MAP3K70.45829876
126MAPK90.44993008
127AURKA0.44481885
128BMX0.44069802
129PLK10.43605093
130PAK30.43582548
131TIE10.42549076
132MAPK70.42392306
133TAOK10.41012066
134CAMK10.39864274
135FLT30.39521980
136RPS6KA10.38251567
137CSNK1D0.38241478
138MARK30.38173086
139NME20.37976244
140BTK0.37581660
141CAMK2A0.37153669
142PRKCZ0.36793510
143PRKD10.36258709
144MAP3K110.35938354
145MAP2K60.35908937
146PRKAA20.35328491
147PAK40.33568928
148CDK70.33523009
149WNK40.33398616
150TNK20.33148873
151AURKB0.32877294
152PRKCA0.32844289
153CDK40.32133887
154PRKAA10.31737903
155STK160.31044501
156ILK0.28627190
157SCYL20.28120196
158TEC0.28075703
159FGFR30.27862204
160AKT30.27320395
161MAP2K10.26540476
162TNIK0.26202846
163PAK60.25995988
164CHEK20.24925398
165EIF2AK20.23972536
166MARK20.22968989
167AKT20.22128097
168CSNK1E0.19400983

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047447.48836316
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.08106206
3Oxidative phosphorylation_Homo sapiens_hsa001902.95136294
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.63467901
5Circadian rhythm_Homo sapiens_hsa047102.47493515
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31277968
7Olfactory transduction_Homo sapiens_hsa047402.24375741
8Parkinsons disease_Homo sapiens_hsa050122.18756060
9Nitrogen metabolism_Homo sapiens_hsa009102.18264011
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.17614756
11RNA polymerase_Homo sapiens_hsa030202.16723099
12Ether lipid metabolism_Homo sapiens_hsa005652.15660871
13Butanoate metabolism_Homo sapiens_hsa006502.07350317
14Synaptic vesicle cycle_Homo sapiens_hsa047212.04918153
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97639648
16Ribosome_Homo sapiens_hsa030101.93062867
17Homologous recombination_Homo sapiens_hsa034401.86746538
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84659988
19Basal transcription factors_Homo sapiens_hsa030221.80057130
20Basal cell carcinoma_Homo sapiens_hsa052171.79533163
21Linoleic acid metabolism_Homo sapiens_hsa005911.79385096
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70217130
23Fanconi anemia pathway_Homo sapiens_hsa034601.68918133
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62121461
25Insulin secretion_Homo sapiens_hsa049111.58756933
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.55975157
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.54483395
28Tryptophan metabolism_Homo sapiens_hsa003801.51485706
29Huntingtons disease_Homo sapiens_hsa050161.48698818
30Alzheimers disease_Homo sapiens_hsa050101.47754378
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.45013317
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40061328
33One carbon pool by folate_Homo sapiens_hsa006701.39983978
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38426864
35Selenocompound metabolism_Homo sapiens_hsa004501.37221128
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36247160
37Propanoate metabolism_Homo sapiens_hsa006401.34172615
38Hippo signaling pathway_Homo sapiens_hsa043901.33459729
39Vibrio cholerae infection_Homo sapiens_hsa051101.30058059
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29991894
41Hedgehog signaling pathway_Homo sapiens_hsa043401.29314418
42Nicotine addiction_Homo sapiens_hsa050331.29258035
43Proteasome_Homo sapiens_hsa030501.23846909
44Notch signaling pathway_Homo sapiens_hsa043301.22092730
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20711399
46GABAergic synapse_Homo sapiens_hsa047271.19516743
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18688901
48Pancreatic secretion_Homo sapiens_hsa049721.17232121
49Caffeine metabolism_Homo sapiens_hsa002321.14820532
50Bladder cancer_Homo sapiens_hsa052191.13362715
51Steroid biosynthesis_Homo sapiens_hsa001001.12296936
52Non-homologous end-joining_Homo sapiens_hsa034501.11337126
53Fructose and mannose metabolism_Homo sapiens_hsa000511.11112533
54Tight junction_Homo sapiens_hsa045301.11082090
55Regulation of autophagy_Homo sapiens_hsa041401.09865234
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09728369
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09309499
58Primary bile acid biosynthesis_Homo sapiens_hsa001201.07367472
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06094432
60Protein digestion and absorption_Homo sapiens_hsa049741.04420995
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04146275
62Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04108367
63Cardiac muscle contraction_Homo sapiens_hsa042601.03093101
64Peroxisome_Homo sapiens_hsa041461.02172255
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99882309
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.98511771
67Collecting duct acid secretion_Homo sapiens_hsa049660.97909171
68beta-Alanine metabolism_Homo sapiens_hsa004100.95140554
69ECM-receptor interaction_Homo sapiens_hsa045120.94334431
70Adherens junction_Homo sapiens_hsa045200.93685051
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93666204
72Pyrimidine metabolism_Homo sapiens_hsa002400.93407621
73Renin secretion_Homo sapiens_hsa049240.91245334
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90940894
75Sphingolipid metabolism_Homo sapiens_hsa006000.90778044
76Ovarian steroidogenesis_Homo sapiens_hsa049130.89765228
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89585537
78Arachidonic acid metabolism_Homo sapiens_hsa005900.89027805
79Endometrial cancer_Homo sapiens_hsa052130.88919074
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88732770
81Alcoholism_Homo sapiens_hsa050340.87093870
82Circadian entrainment_Homo sapiens_hsa047130.86448839
83Taste transduction_Homo sapiens_hsa047420.84752933
84Chemical carcinogenesis_Homo sapiens_hsa052040.84630878
85Metabolic pathways_Homo sapiens_hsa011000.84539533
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84395090
87Cholinergic synapse_Homo sapiens_hsa047250.84110470
88mTOR signaling pathway_Homo sapiens_hsa041500.83577432
89Morphine addiction_Homo sapiens_hsa050320.81594998
90Acute myeloid leukemia_Homo sapiens_hsa052210.81300415
91Glucagon signaling pathway_Homo sapiens_hsa049220.80707229
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80021186
93Wnt signaling pathway_Homo sapiens_hsa043100.79373378
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78669195
95Inositol phosphate metabolism_Homo sapiens_hsa005620.77932624
96Nucleotide excision repair_Homo sapiens_hsa034200.77234787
97Fatty acid elongation_Homo sapiens_hsa000620.76545856
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74878478
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.74612578
100Spliceosome_Homo sapiens_hsa030400.74139255
101VEGF signaling pathway_Homo sapiens_hsa043700.71833664
102Galactose metabolism_Homo sapiens_hsa000520.71355386
103Colorectal cancer_Homo sapiens_hsa052100.71140252
104Sulfur relay system_Homo sapiens_hsa041220.70704109
105Sulfur metabolism_Homo sapiens_hsa009200.69930744
106Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67935800
107Dopaminergic synapse_Homo sapiens_hsa047280.67009427
108Oxytocin signaling pathway_Homo sapiens_hsa049210.66661348
109Protein export_Homo sapiens_hsa030600.66574348
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65156301
111Salivary secretion_Homo sapiens_hsa049700.65079589
112HTLV-I infection_Homo sapiens_hsa051660.64877933
113Serotonergic synapse_Homo sapiens_hsa047260.64306118
114Melanogenesis_Homo sapiens_hsa049160.63515729
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62989426
116Fatty acid biosynthesis_Homo sapiens_hsa000610.62040948
117Glutamatergic synapse_Homo sapiens_hsa047240.61733046
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61713519
119Primary immunodeficiency_Homo sapiens_hsa053400.60261588
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58475991
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58450506
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58115341
123Pathways in cancer_Homo sapiens_hsa052000.56767708
124p53 signaling pathway_Homo sapiens_hsa041150.56528168
125Retinol metabolism_Homo sapiens_hsa008300.56115118
126Prolactin signaling pathway_Homo sapiens_hsa049170.55612496
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.55274448
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.55151448
129Thyroid cancer_Homo sapiens_hsa052160.54882677
130Chronic myeloid leukemia_Homo sapiens_hsa052200.54829757
131mRNA surveillance pathway_Homo sapiens_hsa030150.54752719
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54403794
133Proteoglycans in cancer_Homo sapiens_hsa052050.53991133
134Dorso-ventral axis formation_Homo sapiens_hsa043200.53153082
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52415743
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51828855
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51695627
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.51331657
139Fat digestion and absorption_Homo sapiens_hsa049750.51100619
140AMPK signaling pathway_Homo sapiens_hsa041520.49951804
141Melanoma_Homo sapiens_hsa052180.49566654
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.49090565
143Dilated cardiomyopathy_Homo sapiens_hsa054140.48336474
144Small cell lung cancer_Homo sapiens_hsa052220.48074280
145Type II diabetes mellitus_Homo sapiens_hsa049300.47750174
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47154242
147RNA degradation_Homo sapiens_hsa030180.47021881
148Estrogen signaling pathway_Homo sapiens_hsa049150.46129696
149HIF-1 signaling pathway_Homo sapiens_hsa040660.45563770
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45177046
151Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44649921
152AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44351536
153Histidine metabolism_Homo sapiens_hsa003400.43869652
154Glycerolipid metabolism_Homo sapiens_hsa005610.42222546
155Fatty acid metabolism_Homo sapiens_hsa012120.41577410
156Ras signaling pathway_Homo sapiens_hsa040140.41123999
157PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39945963
158ABC transporters_Homo sapiens_hsa020100.39072675
159Calcium signaling pathway_Homo sapiens_hsa040200.38629380
160Insulin resistance_Homo sapiens_hsa049310.37815849
161Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37416445
162SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36960642
163Viral carcinogenesis_Homo sapiens_hsa052030.36940977
164GnRH signaling pathway_Homo sapiens_hsa049120.34892226
165Fatty acid degradation_Homo sapiens_hsa000710.34745557
166RNA transport_Homo sapiens_hsa030130.34661415
167Purine metabolism_Homo sapiens_hsa002300.34635650
168Mineral absorption_Homo sapiens_hsa049780.34211744
169Pyruvate metabolism_Homo sapiens_hsa006200.34171948
170TGF-beta signaling pathway_Homo sapiens_hsa043500.33475935

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