KLB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.28372774
2L-phenylalanine catabolic process (GO:0006559)7.28372774
3L-phenylalanine metabolic process (GO:0006558)6.96853287
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.96853287
5aromatic amino acid family catabolic process (GO:0009074)6.23642964
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.20472711
7alpha-linolenic acid metabolic process (GO:0036109)5.47682065
8bile acid biosynthetic process (GO:0006699)5.36961061
9sulfur amino acid catabolic process (GO:0000098)5.35204974
10indole-containing compound catabolic process (GO:0042436)5.33145498
11indolalkylamine catabolic process (GO:0046218)5.33145498
12tryptophan catabolic process (GO:0006569)5.33145498
13cysteine metabolic process (GO:0006534)5.30613082
14kynurenine metabolic process (GO:0070189)5.30116576
15negative regulation of fibrinolysis (GO:0051918)5.28236542
16urea cycle (GO:0000050)5.25620553
17urea metabolic process (GO:0019627)5.25620553
18glyoxylate metabolic process (GO:0046487)5.23033900
19high-density lipoprotein particle remodeling (GO:0034375)5.19949463
20serine family amino acid catabolic process (GO:0009071)5.12221709
21tryptophan metabolic process (GO:0006568)5.10007413
22complement activation, alternative pathway (GO:0006957)5.09058223
23regulation of fibrinolysis (GO:0051917)5.01798543
24regulation of protein activation cascade (GO:2000257)4.95945893
25protein carboxylation (GO:0018214)4.92966310
26peptidyl-glutamic acid carboxylation (GO:0017187)4.92966310
27regulation of triglyceride catabolic process (GO:0010896)4.85214379
28nitrogen cycle metabolic process (GO:0071941)4.84580562
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.75711548
30bile acid metabolic process (GO:0008206)4.73963149
31triglyceride homeostasis (GO:0070328)4.71473543
32acylglycerol homeostasis (GO:0055090)4.71473543
33plasma lipoprotein particle clearance (GO:0034381)4.67970437
34reverse cholesterol transport (GO:0043691)4.65454087
35homocysteine metabolic process (GO:0050667)4.64504782
36regulation of complement activation (GO:0030449)4.62831130
37regulation of cholesterol esterification (GO:0010872)4.62551522
38aromatic amino acid family metabolic process (GO:0009072)4.62347619
39plasma lipoprotein particle remodeling (GO:0034369)4.61519594
40protein-lipid complex remodeling (GO:0034368)4.61519594
41macromolecular complex remodeling (GO:0034367)4.61519594
42amino-acid betaine metabolic process (GO:0006577)4.57458743
43tyrosine metabolic process (GO:0006570)4.51490969
44alpha-amino acid catabolic process (GO:1901606)4.46184637
45lysine catabolic process (GO:0006554)4.43534561
46lysine metabolic process (GO:0006553)4.43534561
47glycine metabolic process (GO:0006544)4.39823122
48low-density lipoprotein particle clearance (GO:0034383)4.33565585
49phospholipid efflux (GO:0033700)4.33522078
50protein-lipid complex subunit organization (GO:0071825)4.26643142
51diacylglycerol metabolic process (GO:0046339)4.26265308
52positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.22088016
53negative regulation of protein activation cascade (GO:2000258)4.20637826
54cellular amino acid catabolic process (GO:0009063)4.18330754
55serine family amino acid metabolic process (GO:0009069)4.16243877
56cellular ketone body metabolic process (GO:0046950)4.15500656
57negative regulation of sterol transport (GO:0032372)4.15206442
58negative regulation of cholesterol transport (GO:0032375)4.15206442
59coenzyme catabolic process (GO:0009109)4.05545015
60cholesterol efflux (GO:0033344)4.03821664
61bile acid and bile salt transport (GO:0015721)3.97369500
62positive regulation of lipid catabolic process (GO:0050996)3.96824574
63serine family amino acid biosynthetic process (GO:0009070)3.95392402
64plasma lipoprotein particle assembly (GO:0034377)3.94928777
65regulation of plasminogen activation (GO:0010755)3.92724791
66positive regulation of fatty acid beta-oxidation (GO:0032000)3.89793730
67fatty acid beta-oxidation (GO:0006635)3.85204691
68acetyl-CoA metabolic process (GO:0006084)3.84361150
69neutral lipid catabolic process (GO:0046461)3.84171516
70acylglycerol catabolic process (GO:0046464)3.84171516
71cellular modified amino acid catabolic process (GO:0042219)3.82579227
72carboxylic acid catabolic process (GO:0046395)3.81938735
73organic acid catabolic process (GO:0016054)3.81938735
74indolalkylamine metabolic process (GO:0006586)3.81238453
75imidazole-containing compound metabolic process (GO:0052803)3.80735968
76intestinal cholesterol absorption (GO:0030299)3.79555832
77short-chain fatty acid metabolic process (GO:0046459)3.78989038
78glutamate metabolic process (GO:0006536)3.78803416
79fatty acid oxidation (GO:0019395)3.78296607
80phospholipid homeostasis (GO:0055091)3.77558288
81cholesterol homeostasis (GO:0042632)3.72820596
82valine metabolic process (GO:0006573)3.72610544
83positive regulation of triglyceride lipase activity (GO:0061365)3.71866205
84positive regulation of lipoprotein lipase activity (GO:0051006)3.71866205
85cellular biogenic amine catabolic process (GO:0042402)3.70854343
86amine catabolic process (GO:0009310)3.70854343
87lipid oxidation (GO:0034440)3.70305620
88low-density lipoprotein particle remodeling (GO:0034374)3.70170706
89very-low-density lipoprotein particle assembly (GO:0034379)3.69228886
90fatty acid catabolic process (GO:0009062)3.68042116
91intestinal absorption (GO:0050892)3.67597964
92sterol homeostasis (GO:0055092)3.66829975
93monocarboxylic acid catabolic process (GO:0072329)3.66676572
94ethanol oxidation (GO:0006069)3.65682326
95negative regulation of lipase activity (GO:0060192)3.64210736
96fibrinolysis (GO:0042730)3.61996377
97cellular glucuronidation (GO:0052695)3.61772780
98benzene-containing compound metabolic process (GO:0042537)3.61601687
99regulation of cholesterol homeostasis (GO:2000188)3.61040943
100triglyceride catabolic process (GO:0019433)3.58893198
101ketone body metabolic process (GO:1902224)3.57674434
102plasma lipoprotein particle organization (GO:0071827)3.55843179
103regulation of bile acid biosynthetic process (GO:0070857)3.55456193
104arginine metabolic process (GO:0006525)3.53978533
105protein-lipid complex assembly (GO:0065005)3.52602583
106dicarboxylic acid biosynthetic process (GO:0043650)3.52309999
107lipoprotein metabolic process (GO:0042157)3.52242732
108drug catabolic process (GO:0042737)3.51786284
109sterol transport (GO:0015918)3.50923135
110cholesterol transport (GO:0030301)3.50923135
111blood coagulation, intrinsic pathway (GO:0007597)3.49823654
1122-oxoglutarate metabolic process (GO:0006103)3.49787111
113exogenous drug catabolic process (GO:0042738)3.36926954
114negative regulation of complement activation (GO:0045916)3.32073119
115peptidyl-glutamic acid modification (GO:0018200)3.30853171
116nephron epithelium morphogenesis (GO:0072088)3.25910119
117nephron tubule morphogenesis (GO:0072078)3.25910119
118water-soluble vitamin biosynthetic process (GO:0042364)3.22885131
119transepithelial transport (GO:0070633)3.19020684
120lipid homeostasis (GO:0055088)3.16781702
121glycerolipid catabolic process (GO:0046503)3.12051788
122negative regulation of sodium ion transport (GO:0010766)3.10703724
123behavioral response to nicotine (GO:0035095)3.09488178
124regulation of apoptotic cell clearance (GO:2000425)3.08683863
125protein activation cascade (GO:0072376)3.07708974
126heme transport (GO:0015886)3.03438125
127regulation of humoral immune response (GO:0002920)2.97559152
128acute-phase response (GO:0006953)2.97440181
129epoxygenase P450 pathway (GO:0019373)2.96382638
130negative regulation of blood coagulation (GO:0030195)2.95183483
131negative regulation of hemostasis (GO:1900047)2.95183483
132positive regulation of fatty acid biosynthetic process (GO:0045723)2.90510149
133positive regulation of lipid storage (GO:0010884)2.89579167
134ethanol metabolic process (GO:0006067)2.88334534
135fatty acid homeostasis (GO:0055089)2.86186448
136peristalsis (GO:0030432)2.86151239
137purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.84387057
1383-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.84387057
139S-adenosylmethionine metabolic process (GO:0046500)2.81843346
140positive regulation of fatty acid metabolic process (GO:0045923)2.78879342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.06035905
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.96286836
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.44050092
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.39098844
5* LXR_22158963_ChIP-Seq_LIVER_Mouse6.28830450
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.11578525
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.07929349
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.01046335
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.76556795
10ZNF274_21170338_ChIP-Seq_K562_Hela3.19573460
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.93713661
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80361515
13VDR_22108803_ChIP-Seq_LS180_Human2.40801036
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.15673526
15CLOCK_20551151_ChIP-Seq_293T_Human2.11962802
16GBX2_23144817_ChIP-Seq_PC3_Human2.03010040
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3284367
18IGF1R_20145208_ChIP-Seq_DFB_Human1.97128789
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.95763085
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90014604
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.69747158
22GATA1_22025678_ChIP-Seq_K562_Human1.67795205
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60177805
24* FOXA2_19822575_ChIP-Seq_HepG2_Human1.52861526
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.50111167
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.48398873
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47474223
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42697779
29* HNF4A_19822575_ChIP-Seq_HepG2_Human1.41219018
30TAF15_26573619_Chip-Seq_HEK293_Human1.39777226
31HTT_18923047_ChIP-ChIP_STHdh_Human1.37675476
32* ERA_21632823_ChIP-Seq_H3396_Human1.37303208
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36785220
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35334972
35ER_23166858_ChIP-Seq_MCF-7_Human1.34624496
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32879151
37BCAT_22108803_ChIP-Seq_LS180_Human1.30971627
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.30653204
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30107154
40GATA3_21878914_ChIP-Seq_MCF-7_Human1.29733735
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28705358
42AR_21572438_ChIP-Seq_LNCaP_Human1.28088972
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26869968
44RXRA_24833708_ChIP-Seq_LIVER_Mouse1.25236229
45* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24422492
46MYC_19829295_ChIP-Seq_ESCs_Human1.24203534
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22935893
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.18741058
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17151288
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.17039696
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17039696
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16726017
53OCT4_20526341_ChIP-Seq_ESCs_Human1.13680891
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11025647
55SOX2_19829295_ChIP-Seq_ESCs_Human1.10263647
56NANOG_19829295_ChIP-Seq_ESCs_Human1.10263647
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.09812162
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09521460
59NCOR_22424771_ChIP-Seq_293T_Human1.08939231
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08865917
61STAT3_23295773_ChIP-Seq_U87_Human1.07380857
62* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.07298518
63P300_19829295_ChIP-Seq_ESCs_Human1.06391231
64ZNF263_19887448_ChIP-Seq_K562_Human1.05859841
65NANOG_20526341_ChIP-Seq_ESCs_Human1.05776243
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04882928
67* TP53_22573176_ChIP-Seq_HFKS_Human1.03462324
68EWS_26573619_Chip-Seq_HEK293_Human1.03261873
69FUS_26573619_Chip-Seq_HEK293_Human1.02085471
70HOXB7_26014856_ChIP-Seq_BT474_Human1.02081621
71GATA4_25053715_ChIP-Seq_YYC3_Human1.01728017
72IRF1_19129219_ChIP-ChIP_H3396_Human0.99356380
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99177748
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99081374
75CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98624858
76CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97947198
77TCF4_22108803_ChIP-Seq_LS180_Human0.97032525
78SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96423427
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95233527
80KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94922519
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94549135
82* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92406758
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91821502
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91013689
85FOXH1_21741376_ChIP-Seq_EPCs_Human0.90993877
86KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90868258
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89962827
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89886309
89TCF4_18268006_ChIP-ChIP_LS174T_Human0.89474148
90RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89252717
91TP53_16413492_ChIP-PET_HCT116_Human0.89220208
92RARA_24833708_ChIP-Seq_LIVER_Mouse0.87049921
93CDX2_22108803_ChIP-Seq_LS180_Human0.86907462
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85958183
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85446739
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84911786
97CBP_20019798_ChIP-Seq_JUKART_Human0.84911786
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.84551772
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84043283
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83684468
101E2F1_20622854_ChIP-Seq_HELA_Human0.82678919
102AR_25329375_ChIP-Seq_VCAP_Human0.82566747
103TCF4_23295773_ChIP-Seq_U87_Human0.82181217
104FOXH1_21741376_ChIP-Seq_ESCs_Human0.81314893
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81225809
106SMAD4_21741376_ChIP-Seq_EPCs_Human0.81161731
107FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81083209
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79744995
109IRF8_22096565_ChIP-ChIP_GC-B_Human0.79702336
110AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78809546
111NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.78528443
112RXR_22108803_ChIP-Seq_LS180_Human0.78148790
113CRX_20693478_ChIP-Seq_RETINA_Mouse0.77938182
114FOXA1_21572438_ChIP-Seq_LNCaP_Human0.77684133
115RARB_24833708_ChIP-Seq_LIVER_Mouse0.77156683
116POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76768403
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75979506
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73455327
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.72397372
120* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.71009562
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.69967058
122ESR1_15608294_ChIP-ChIP_MCF-7_Human0.68868566
123FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.66508388
124FOXA1_25552417_ChIP-Seq_VCAP_Human0.65159581
125TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.64334620
126AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.64156075
127BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59490701
128FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.59225366
129GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.57227287
130AR_20517297_ChIP-Seq_VCAP_Human0.56839446
131RAD21_21589869_ChIP-Seq_MESCs_Mouse0.56475403
132CEBPB_22108803_ChIP-Seq_LS180_Human0.55889823
133BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.55172339
134PPAR_26484153_Chip-Seq_NCI-H1993_Human0.53319237
135GATA6_25053715_ChIP-Seq_YYC3_Human0.51858711
136IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.50907214
137Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.50517238
138ESET_19884257_ChIP-Seq_ESCs_Mouse0.49486969
139P53_21459846_ChIP-Seq_SAOS-2_Human0.48729439
140ERG_20517297_ChIP-Seq_VCAP_Human0.46357654
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.45971381
142TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.45899063
143GATA1_19941826_ChIP-Seq_K562_Human0.45092669
144GATA3_24758297_ChIP-Seq_MCF-7_Human0.44373256
145FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.44003214
146FOXO3_23340844_ChIP-Seq_DLD1_Human0.43876982
147MYC_19915707_ChIP-ChIP_AK7_Human0.43524632
148CBP_21632823_ChIP-Seq_H3396_Human0.42748066
149TAF2_19829295_ChIP-Seq_ESCs_Human0.42697727
150STAT1_17558387_ChIP-Seq_HELA_Human0.42395244
151NRF2_20460467_ChIP-Seq_MEFs_Mouse0.42198329
152NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.42198329
153PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.41586169
154TET1_21451524_ChIP-Seq_MESCs_Mouse0.40844413
155LXR_22292898_ChIP-Seq_THP-1_Human0.40612744
156SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.39214742
157AR_21909140_ChIP-Seq_LNCAP_Human0.38746086
158RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.38489812
159CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.38308415
160* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.38105826
161SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38033698
162SPI1_26923725_Chip-Seq_HPCs_Mouse0.37976599
163BCOR_27268052_Chip-Seq_Bcells_Human0.37932695
164PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.37659621
165RAC3_21632823_ChIP-Seq_H3396_Human0.35860038
166SOX2_18692474_ChIP-Seq_MEFs_Mouse0.35689055
167BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.35383284
168SOX2_22085726_ChIP-Seq_NPCs_Mouse0.34080947
169SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33864464
170SOX2_20726797_ChIP-Seq_SW620_Human0.33599653
171TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.33052925

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.81188778
2MP0005360_urolithiasis6.94780828
3* MP0005365_abnormal_bile_salt6.15196779
4MP0005085_abnormal_gallbladder_physiolo6.02163688
5MP0008875_abnormal_xenobiotic_pharmacok4.43155234
6MP0003806_abnormal_nucleotide_metabolis4.03593614
7MP0010329_abnormal_lipoprotein_level3.80332622
8MP0003252_abnormal_bile_duct3.54191946
9MP0009840_abnormal_foam_cell3.17097791
10MP0003195_calcinosis3.14973872
11MP0005083_abnormal_biliary_tract3.11367492
12MP0003122_maternal_imprinting3.05462001
13MP0001666_abnormal_nutrient_absorption2.87579418
14MP0005332_abnormal_amino_acid2.84606668
15MP0002118_abnormal_lipid_homeostasis2.34807431
16MP0003191_abnormal_cellular_cholesterol2.32338548
17MP0004019_abnormal_vitamin_homeostasis2.28388145
18MP0001986_abnormal_taste_sensitivity2.26305980
19* MP0000609_abnormal_liver_physiology2.23871506
20MP0005670_abnormal_white_adipose2.10675570
21MP0003136_yellow_coat_color2.05238387
22MP0001764_abnormal_homeostasis1.89650574
23MP0005551_abnormal_eye_electrophysiolog1.88788088
24MP0003868_abnormal_feces_composition1.86883287
25MP0002638_abnormal_pupillary_reflex1.83605428
26MP0002138_abnormal_hepatobiliary_system1.82152720
27MP0005319_abnormal_enzyme/_coenzyme1.80158613
28MP0005167_abnormal_blood-brain_barrier1.62933501
29MP0005584_abnormal_enzyme/coenzyme_acti1.48771302
30MP0009697_abnormal_copulation1.48614770
31MP0003186_abnormal_redox_activity1.42713202
32MP0009643_abnormal_urine_homeostasis1.40197168
33MP0004130_abnormal_muscle_cell1.39349079
34MP0005451_abnormal_body_composition1.31861520
35MP0005666_abnormal_adipose_tissue1.24245312
36MP0002971_abnormal_brown_adipose1.24030577
37MP0003705_abnormal_hypodermis_morpholog1.23873069
38MP0005220_abnormal_exocrine_pancreas1.23387593
39MP0009780_abnormal_chondrocyte_physiolo1.21493316
40MP0002938_white_spotting1.20866556
41MP0000598_abnormal_liver_morphology1.19817625
42MP0002078_abnormal_glucose_homeostasis1.15158816
43MP0003011_delayed_dark_adaptation1.15156750
44MP0002876_abnormal_thyroid_physiology1.13281541
45MP0003123_paternal_imprinting1.11360758
46MP0003656_abnormal_erythrocyte_physiolo1.10363003
47MP0001661_extended_life_span1.08701056
48MP0000013_abnormal_adipose_tissue1.07914831
49MP0006036_abnormal_mitochondrial_physio1.06090971
50MP0002837_dystrophic_cardiac_calcinosis1.05063191
51MP0005334_abnormal_fat_pad1.04486369
52MP0002160_abnormal_reproductive_system1.03783586
53MP0000566_synostosis1.03362460
54MP0003121_genomic_imprinting1.00492616
55MP0005636_abnormal_mineral_homeostasis1.00347932
56MP0004133_heterotaxia0.97475236
57MP0005410_abnormal_fertilization0.97109526
58MP0005647_abnormal_sex_gland0.96612991
59MP0001324_abnormal_eye_pigmentation0.95761682
60MP0001756_abnormal_urination0.95735825
61MP0002254_reproductive_system_inflammat0.95673943
62MP0008872_abnormal_physiological_respon0.95347829
63MP0005535_abnormal_body_temperature0.95300831
64MP0001968_abnormal_touch/_nociception0.94447100
65MP0009763_increased_sensitivity_to0.93713562
66MP0005408_hypopigmentation0.93623719
67MP0000604_amyloidosis0.92947749
68MP0005375_adipose_tissue_phenotype0.90887905
69MP0005174_abnormal_tail_pigmentation0.90441142
70MP0004185_abnormal_adipocyte_glucose0.89561607
71MP0009642_abnormal_blood_homeostasis0.89220025
72MP0005448_abnormal_energy_balance0.88655068
73MP0002089_abnormal_postnatal_growth/wei0.87951743
74MP0005646_abnormal_pituitary_gland0.87568009
75MP0004142_abnormal_muscle_tone0.87089841
76MP0005376_homeostasis/metabolism_phenot0.82719191
77MP0008469_abnormal_protein_level0.79893649
78MP0004264_abnormal_extraembryonic_tissu0.78170077
79MP0003878_abnormal_ear_physiology0.76786270
80MP0005377_hearing/vestibular/ear_phenot0.76786270
81MP0000003_abnormal_adipose_tissue0.75146983
82MP0010368_abnormal_lymphatic_system0.74387127
83MP0003959_abnormal_lean_body0.73664242
84MP0003879_abnormal_hair_cell0.72965169
85MP0009764_decreased_sensitivity_to0.72558728
86MP0001270_distended_abdomen0.71755069
87MP0005195_abnormal_posterior_eye0.70892266
88MP0000639_abnormal_adrenal_gland0.70128760
89MP0009115_abnormal_fat_cell0.69738086
90MP0002970_abnormal_white_adipose0.69297101
91MP0005266_abnormal_metabolism0.68866839
92MP0005389_reproductive_system_phenotype0.68564214
93MP0009765_abnormal_xenobiotic_induced0.66481276
94MP0003953_abnormal_hormone_level0.65600681
95MP0003567_abnormal_fetal_cardiomyocyte0.65456806
96MP0002933_joint_inflammation0.65368064
97MP0001501_abnormal_sleep_pattern0.64824700
98MP0010386_abnormal_urinary_bladder0.62953240
99MP0003718_maternal_effect0.62645303
100MP0005395_other_phenotype0.61453407
101MP0001944_abnormal_pancreas_morphology0.61408300
102MP0003690_abnormal_glial_cell0.61131202
103MP0009046_muscle_twitch0.61037897
104MP0003890_abnormal_embryonic-extraembry0.60907223
105MP0002132_abnormal_respiratory_system0.60806129
106MP0003950_abnormal_plasma_membrane0.60107764
107MP0003632_abnormal_nervous_system0.59823965
108MP0005253_abnormal_eye_physiology0.59672901
109MP0002557_abnormal_social/conspecific_i0.58927597
110MP0008877_abnormal_DNA_methylation0.58386776
111* MP0005084_abnormal_gallbladder_morpholo0.58108435
112MP0000538_abnormal_urinary_bladder0.57847659
113MP0006035_abnormal_mitochondrial_morpho0.57729103
114MP0005379_endocrine/exocrine_gland_phen0.57363018
115MP0003646_muscle_fatigue0.56651208
116MP0006292_abnormal_olfactory_placode0.56577498
117MP0009672_abnormal_birth_weight0.56542080
118MP0006276_abnormal_autonomic_nervous0.56537274
119MP0001502_abnormal_circadian_rhythm0.56189217
120MP0003329_amyloid_beta_deposits0.54107095
121MP0002136_abnormal_kidney_physiology0.49926059
122MP0005058_abnormal_lysosome_morphology0.49459165
123MP0004782_abnormal_surfactant_physiolog0.44270976
124MP0005452_abnormal_adipose_tissue0.43889505
125MP0003638_abnormal_response/metabolism_0.43595025
126MP0002168_other_aberrant_phenotype0.42664374
127MP0009053_abnormal_anal_canal0.41167869
128MP0002796_impaired_skin_barrier0.40702040
129MP0003724_increased_susceptibility_to0.40253037
130MP0001881_abnormal_mammary_gland0.38818858
131MP0002928_abnormal_bile_duct0.37064496
132MP0000230_abnormal_systemic_arterial0.37046442
133MP0002060_abnormal_skin_morphology0.35340777
134MP0004043_abnormal_pH_regulation0.34660394
135MP0002909_abnormal_adrenal_gland0.34497323
136MP0002693_abnormal_pancreas_physiology0.34475613
137MP0002269_muscular_atrophy0.32271418
138MP0005464_abnormal_platelet_physiology0.32026076
139MP0010234_abnormal_vibrissa_follicle0.30146209
140MP0008438_abnormal_cutaneous_collagen0.29964082
141MP0008873_increased_physiological_sensi0.28746576
142MP0009384_cardiac_valve_regurgitation0.27660870
143MP0001243_abnormal_dermal_layer0.26170168
144MP0005164_abnormal_response_to0.25303666

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.08396989
2Intrahepatic cholestasis (HP:0001406)6.65364503
3Deep venous thrombosis (HP:0002625)6.64750235
4Xanthomatosis (HP:0000991)6.14156989
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.92606784
6Hypobetalipoproteinemia (HP:0003563)5.91914989
7Prolonged partial thromboplastin time (HP:0003645)5.91040743
8Hyperlipoproteinemia (HP:0010980)5.30643047
9Hypoglycemic coma (HP:0001325)5.07082135
10Complement deficiency (HP:0004431)5.02532852
11Hyperglycinemia (HP:0002154)4.95422863
12Hyperglycinuria (HP:0003108)4.81488388
13Hypolipoproteinemia (HP:0010981)4.70611679
14Hyperammonemia (HP:0001987)4.68022795
15Ketosis (HP:0001946)4.62571895
16Abnormality of glycine metabolism (HP:0010895)4.54935682
17Abnormality of serine family amino acid metabolism (HP:0010894)4.54935682
18Epidermoid cyst (HP:0200040)4.46654265
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.39087849
20Abnormality of the common coagulation pathway (HP:0010990)4.27715536
21Hypoalphalipoproteinemia (HP:0003233)4.25356786
22Joint hemorrhage (HP:0005261)4.23338537
23Abnormality of the intrinsic pathway (HP:0010989)3.93383058
24Fat malabsorption (HP:0002630)3.92997325
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.90959991
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.90519315
27Abnormality of methionine metabolism (HP:0010901)3.89929668
28Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.85745817
29Abnormality of fatty-acid metabolism (HP:0004359)3.81891555
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.81422456
31Ketoacidosis (HP:0001993)3.71966488
32Abnormality of complement system (HP:0005339)3.62832355
33Hypercholesterolemia (HP:0003124)3.60271974
34Conjugated hyperbilirubinemia (HP:0002908)3.56846693
35Hypoglycemic seizures (HP:0002173)3.45612178
36Abnormality of pyrimidine metabolism (HP:0004353)3.35673320
37Abnormality of serum amino acid levels (HP:0003112)3.31625224
38Hypophosphatemic rickets (HP:0004912)3.24982988
39Hyperbilirubinemia (HP:0002904)3.13506122
40Abnormality of alanine metabolism (HP:0010916)3.11080307
41Hyperalaninemia (HP:0003348)3.11080307
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.11080307
43Hyperinsulinemic hypoglycemia (HP:0000825)3.03816037
44Myocardial infarction (HP:0001658)2.99433101
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.98950979
46Dicarboxylic aciduria (HP:0003215)2.98950979
47Skin nodule (HP:0200036)2.95890665
48Hyperglycemia (HP:0003074)2.93498434
49Abnormality of nucleobase metabolism (HP:0010932)2.89688603
50Steatorrhea (HP:0002570)2.84807354
51Delayed CNS myelination (HP:0002188)2.81683858
52Lethargy (HP:0001254)2.80903042
53Gout (HP:0001997)2.74546306
54Congenital stationary night blindness (HP:0007642)2.73981037
55Metabolic acidosis (HP:0001942)2.73203901
56Hepatocellular carcinoma (HP:0001402)2.69672561
57Arthropathy (HP:0003040)2.68356092
58Abnormality of purine metabolism (HP:0004352)2.66696244
59Spontaneous abortion (HP:0005268)2.62877390
60Acanthocytosis (HP:0001927)2.52895209
61Hypochromic microcytic anemia (HP:0004840)2.51754449
62Hypothermia (HP:0002045)2.49570372
63Pigmentary retinal degeneration (HP:0001146)2.48879971
64Attenuation of retinal blood vessels (HP:0007843)2.48842327
65Irritability (HP:0000737)2.47802069
66Late onset (HP:0003584)2.47743796
67Abnormality of the nasal septum (HP:0000419)2.47673499
68Cerebral edema (HP:0002181)2.46630794
69Vaginal fistula (HP:0004320)2.46598976
70Pancreatitis (HP:0001733)2.42892414
71Brushfield spots (HP:0001088)2.40976506
72Potter facies (HP:0002009)2.40742039
73Facial shape deformation (HP:0011334)2.40742039
74Systemic lupus erythematosus (HP:0002725)2.40186768
75Symptomatic seizures (HP:0011145)2.34552256
76Generalized aminoaciduria (HP:0002909)2.34413036
77Glycosuria (HP:0003076)2.32194324
78Abnormality of urine glucose concentration (HP:0011016)2.32194324
79Abnormal gallbladder morphology (HP:0012437)2.28553327
80Glomerulonephritis (HP:0000099)2.19714037
81Rickets (HP:0002748)2.16296534
82Retinal atrophy (HP:0001105)2.16172566
83Spastic diplegia (HP:0001264)2.16105051
84Enlarged kidneys (HP:0000105)2.15941585
85Proximal tubulopathy (HP:0000114)2.15304878
86Abnormal urine output (HP:0012590)2.13953578
87Decreased central vision (HP:0007663)2.13547519
88Hypertriglyceridemia (HP:0002155)2.12336762
89Vomiting (HP:0002013)2.10950750
90Bile duct proliferation (HP:0001408)2.10187207
91Abnormal biliary tract physiology (HP:0012439)2.10187207
92Abnormality of proline metabolism (HP:0010907)2.09627164
93Hydroxyprolinuria (HP:0003080)2.09627164
94Cholelithiasis (HP:0001081)2.09136846
95Broad alveolar ridges (HP:0000187)2.08923112
96Mitral stenosis (HP:0001718)2.07816692
97Abnormality of the pancreatic islet cells (HP:0006476)2.07703728
98Abnormality of endocrine pancreas physiology (HP:0012093)2.07703728
99Amyloidosis (HP:0011034)2.07220466
100Hemorrhage of the eye (HP:0011885)2.06890125
101Abnormal cartilage morphology (HP:0002763)2.06666797
102Esophageal varix (HP:0002040)2.06363270
103Vascular calcification (HP:0004934)2.06077600
104Pendular nystagmus (HP:0012043)2.06036258
105Mesangial abnormality (HP:0001966)2.05697829
106Abnormality of vitamin metabolism (HP:0100508)2.04126254
107Rectal fistula (HP:0100590)2.03332618
108Rectovaginal fistula (HP:0000143)2.03332618
109Abnormality of the renal cortex (HP:0011035)2.03069045
110Renal cortical cysts (HP:0000803)2.02660854
111Neonatal onset (HP:0003623)2.02133794
112Sensorimotor neuropathy (HP:0007141)2.00353013
113Chorioretinal atrophy (HP:0000533)2.00151526
114Nausea (HP:0002018)1.98485117
115Chronic hepatic failure (HP:0100626)1.98242176
116Osteomalacia (HP:0002749)1.96859990
117Widely patent fontanelles and sutures (HP:0004492)1.95615188
118Decreased circulating renin level (HP:0003351)1.94992819
119Polydipsia (HP:0001959)1.94462810
120Abnormal drinking behavior (HP:0030082)1.94462810
121Fair hair (HP:0002286)1.94357357
122Malnutrition (HP:0004395)1.93344511
123Pancreatic islet-cell hyperplasia (HP:0004510)1.92499867
124Opisthotonus (HP:0002179)1.91658527
125Abnormality of the vitreous humor (HP:0004327)1.91622589
126Tubular atrophy (HP:0000092)1.89999260
127Recurrent gram-negative bacterial infections (HP:0005420)1.86392456
128Epiphyseal stippling (HP:0010655)1.86362635
129Increased purine levels (HP:0004368)1.84454373
130Hyperuricemia (HP:0002149)1.84454373
131Poikilocytosis (HP:0004447)1.84185688
132Cardiovascular calcification (HP:0011915)1.82730949
133Abnormality of transition element cation homeostasis (HP:0011030)1.82285858
134Pancreatic cysts (HP:0001737)1.81730814
135Elevated hepatic transaminases (HP:0002910)1.79617646
136Abnormality of the gallbladder (HP:0005264)1.79213307
137Menorrhagia (HP:0000132)1.78716899
138Gingival bleeding (HP:0000225)1.78536349
139Abnormality of renal excretion (HP:0011036)1.77882143
140Abnormal gallbladder physiology (HP:0012438)1.76649947
141Nephritis (HP:0000123)1.76142935
142Abolished electroretinogram (ERG) (HP:0000550)1.73476187
143Intestinal fistula (HP:0100819)1.71485148
144Supernumerary spleens (HP:0009799)1.71447611
145Molar tooth sign on MRI (HP:0002419)1.71413585
146Abnormality of midbrain morphology (HP:0002418)1.71413585
147Hyperphosphaturia (HP:0003109)1.70610453
148Thrombophlebitis (HP:0004418)1.69819508
149Abnormality of the wing of the ilium (HP:0011867)1.69034740
150Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68159233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.35738313
2SIK14.17988830
3ERN13.89825874
4FGFR43.68806836
5INSRR3.51264395
6WNK33.21404292
7PIK3CG3.16648162
8ZAK2.90762956
9ADRBK22.82469937
10MAPK152.78795382
11BMPR1B2.67071952
12TAOK32.56319580
13TLK12.55672033
14TRIB32.51975625
15ERBB42.23358379
16FRK2.03853382
17PIK3CA1.99917731
18CAMK1D1.99660097
19STK391.96435138
20MST1R1.91049299
21MAP4K21.86648847
22LATS11.67325746
23PKN21.62503558
24CAMKK21.61607279
25FLT31.60515897
26MAPK111.59549335
27TYRO31.41679378
28MAP2K41.40357596
29WNK11.39802503
30STK38L1.39539449
31PRKAA21.39360258
32PINK11.34808462
33CASK1.30978399
34PDK31.25664394
35PDK41.25664394
36DAPK21.24051119
37NEK91.23934434
38NUAK11.18041689
39NEK21.15053814
40ADRBK11.10937232
41PTK61.09437777
42ABL21.09126266
43SIK21.08979933
44IRAK31.07961259
45MUSK1.07959144
46NTRK31.04604199
47PRKAA11.00814382
48TYK20.98570098
49JAK20.96929203
50MAP3K40.96538999
51CAMK1G0.94851247
52MAPK130.91956249
53SGK4940.87669325
54SGK2230.87669325
55FGFR20.87579311
56TGFBR20.84669891
57KDR0.84152932
58FGFR10.82945557
59DYRK1B0.81474626
60WNK40.80681720
61RIPK10.80402831
62CDK60.78601423
63MTOR0.78245132
64EPHA20.77497650
65MET0.77020828
66MAP2K10.76937472
67LATS20.70734720
68PRKACG0.70295255
69MAP3K30.70184377
70JAK10.67931348
71PRKCE0.67355143
72GSK3A0.67209366
73PRKCZ0.66925323
74CSNK1D0.65619054
75EPHA30.65461533
76CSK0.64940383
77AKT30.64814993
78CDK40.64429632
79OXSR10.64046668
80DYRK20.63822019
81PRKG10.62899075
82PDK20.61557161
83NLK0.61503362
84PRKACA0.61395609
85ERBB20.60587981
86PDPK10.60410791
87PHKG10.60184096
88PHKG20.60184096
89MAP3K110.54746526
90STK160.54493380
91SGK20.53766024
92PTK20.53135096
93TIE10.52593327
94CAMK10.52335388
95MAP2K20.52103726
96MAPK40.51924873
97CSNK1E0.51701109
98TGFBR10.49662151
99PAK30.49329578
100MKNK20.49054937
101CSNK1G10.48742455
102MAPKAPK50.48198148
103MAP3K20.47287720
104MAP2K30.46773831
105FGFR30.46684312
106KSR20.46620418
107SGK10.45730254
108BRSK20.45685223
109ACVR1B0.43364135
110PRKCQ0.42918022
111IGF1R0.42859080
112CAMK2G0.42193811
113PRKACB0.41912940
114CHUK0.41739046
115MAP3K60.41737539
116NME10.39557954
117TRIM280.39217071
118PDGFRA0.39195148
119STK30.39136328
120GRK60.37991279
121MAP3K100.37338169
122MAP3K70.37233545
123RPS6KA30.35979571
124MARK10.35413065
125MAPK120.34869045
126PDK10.34492411
127EIF2AK30.32227992
128TBK10.31187571
129STK110.31094780
130IKBKB0.30980170
131IRAK10.30720766
132RPS6KA50.30538206
133PRKCA0.30292281
134MAP2K60.30029220
135ICK0.29323809
136TXK0.29026858
137TRPM70.28914784
138MAP3K50.27871786
139MAPK70.26015680
140RPS6KB10.25883308
141EIF2AK10.25335738
142SGK30.25198848
143ARAF0.25154401
144GRK10.23953080
145PRKCG0.23393793
146NEK10.23188455
147EPHB10.22227530
148MAP3K10.21795891
149RET0.21263466
150FER0.21065062
151MAPKAPK30.18543124
152BRAF0.18223631

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.09552206
2Nitrogen metabolism_Homo sapiens_hsa009103.59603852
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.07062692
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.93923646
5Arginine biosynthesis_Homo sapiens_hsa002202.85710664
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.78884713
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.70660881
8Fatty acid degradation_Homo sapiens_hsa000712.67173709
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.62537816
10Tryptophan metabolism_Homo sapiens_hsa003802.54265436
11Complement and coagulation cascades_Homo sapiens_hsa046102.53298137
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44486677
13Propanoate metabolism_Homo sapiens_hsa006402.37570623
14Butanoate metabolism_Homo sapiens_hsa006502.15534972
15PPAR signaling pathway_Homo sapiens_hsa033202.11802815
16Fatty acid metabolism_Homo sapiens_hsa012122.08017504
17Peroxisome_Homo sapiens_hsa041462.06558622
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05799386
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92251375
20beta-Alanine metabolism_Homo sapiens_hsa004101.83612969
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.76366544
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75541371
23Histidine metabolism_Homo sapiens_hsa003401.74328076
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.73493101
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72709283
26Chemical carcinogenesis_Homo sapiens_hsa052041.71584027
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64089908
28Fat digestion and absorption_Homo sapiens_hsa049751.60885179
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.58326907
30Caffeine metabolism_Homo sapiens_hsa002321.56199410
31Staphylococcus aureus infection_Homo sapiens_hsa051501.56063389
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.55604878
33Selenocompound metabolism_Homo sapiens_hsa004501.53875109
34Pyruvate metabolism_Homo sapiens_hsa006201.53157094
35Phenylalanine metabolism_Homo sapiens_hsa003601.48674985
36Folate biosynthesis_Homo sapiens_hsa007901.47436970
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47041199
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46981589
39Retinol metabolism_Homo sapiens_hsa008301.46665812
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42564702
41Vitamin B6 metabolism_Homo sapiens_hsa007501.39023253
42Fatty acid elongation_Homo sapiens_hsa000621.37502486
43Tyrosine metabolism_Homo sapiens_hsa003501.35385769
44Carbon metabolism_Homo sapiens_hsa012001.32926020
45Sulfur metabolism_Homo sapiens_hsa009201.32196731
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29957645
47Biosynthesis of amino acids_Homo sapiens_hsa012301.26730910
48Bile secretion_Homo sapiens_hsa049761.26681588
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.26052972
50Starch and sucrose metabolism_Homo sapiens_hsa005001.23737311
51ABC transporters_Homo sapiens_hsa020101.18460898
52Steroid biosynthesis_Homo sapiens_hsa001001.07609829
53Glycerolipid metabolism_Homo sapiens_hsa005611.04789381
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04002294
55Vitamin digestion and absorption_Homo sapiens_hsa049771.00498899
56Arginine and proline metabolism_Homo sapiens_hsa003300.99017184
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94061293
58Fatty acid biosynthesis_Homo sapiens_hsa000610.93947593
59Sulfur relay system_Homo sapiens_hsa041220.90246654
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86872468
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.86774546
62Lysine degradation_Homo sapiens_hsa003100.82378683
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81491004
64Ether lipid metabolism_Homo sapiens_hsa005650.78812209
65Pentose phosphate pathway_Homo sapiens_hsa000300.75257426
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73732878
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71366944
68One carbon pool by folate_Homo sapiens_hsa006700.70782617
69Glutathione metabolism_Homo sapiens_hsa004800.67352741
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63099841
71Phototransduction_Homo sapiens_hsa047440.57477422
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57377912
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57128107
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56197671
75Sphingolipid metabolism_Homo sapiens_hsa006000.53385962
76Metabolic pathways_Homo sapiens_hsa011000.51781936
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44065332
78Mineral absorption_Homo sapiens_hsa049780.42137651
79Fructose and mannose metabolism_Homo sapiens_hsa000510.41485625
80Linoleic acid metabolism_Homo sapiens_hsa005910.40169851
81Other glycan degradation_Homo sapiens_hsa005110.37821211
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.37443686
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.35568590
84Prion diseases_Homo sapiens_hsa050200.35488480
85Galactose metabolism_Homo sapiens_hsa000520.34975260
86RNA polymerase_Homo sapiens_hsa030200.33805371
87Taste transduction_Homo sapiens_hsa047420.32468889
88Insulin resistance_Homo sapiens_hsa049310.31629541
89Nicotine addiction_Homo sapiens_hsa050330.28382000
90Glucagon signaling pathway_Homo sapiens_hsa049220.26486585
91AMPK signaling pathway_Homo sapiens_hsa041520.25828263
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23828802
93N-Glycan biosynthesis_Homo sapiens_hsa005100.23503355
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22539499
95Basal transcription factors_Homo sapiens_hsa030220.20899626
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20662006
97Regulation of autophagy_Homo sapiens_hsa041400.17107857
98Oxidative phosphorylation_Homo sapiens_hsa001900.13844819
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11311809
100Insulin signaling pathway_Homo sapiens_hsa049100.06592091
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05489509
102Renin-angiotensin system_Homo sapiens_hsa046140.00092376
103Type II diabetes mellitus_Homo sapiens_hsa04930-0.1743259
104Pancreatic secretion_Homo sapiens_hsa04972-0.1739181
105Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1635563
106Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1508645
107Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1419510
108Lysosome_Homo sapiens_hsa04142-0.1413463
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1407170
110Circadian rhythm_Homo sapiens_hsa04710-0.1163673
111Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1136434
112Protein export_Homo sapiens_hsa03060-0.0810349
113Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0677769
114Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0672964
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0436541
116Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0364460
117Protein digestion and absorption_Homo sapiens_hsa04974-0.0273650

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