KISS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1female pregnancy (GO:0007565)9.96122655
2response to follicle-stimulating hormone (GO:0032354)9.46379284
3response to dietary excess (GO:0002021)8.29576864
4estrogen metabolic process (GO:0008210)8.12310298
5glucocorticoid biosynthetic process (GO:0006704)8.02313480
6regulation of female receptivity (GO:0045924)7.48727536
7hyperosmotic salinity response (GO:0042538)7.21473931
8sodium-independent organic anion transport (GO:0043252)7.17586468
9regulation of transmission of nerve impulse (GO:0051969)6.97116771
10multi-multicellular organism process (GO:0044706)6.95836555
11prostate gland growth (GO:0060736)6.75750037
12androgen biosynthetic process (GO:0006702)6.72317032
13female mating behavior (GO:0060180)6.50778687
14positive regulation of amino acid transport (GO:0051957)6.24999564
15multi-organism reproductive process (GO:0044703)6.05489057
16positive regulation of fatty acid biosynthetic process (GO:0045723)5.96391272
17maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.89897826
18aggressive behavior (GO:0002118)5.74725404
19androgen metabolic process (GO:0008209)5.59511464
20negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.46681886
21protein retention in ER lumen (GO:0006621)5.40096950
22protein kinase C signaling (GO:0070528)5.35752513
23proline biosynthetic process (GO:0006561)5.29926755
24sexual reproduction (GO:0019953)5.27389247
25response to testosterone (GO:0033574)5.23296563
26intestinal epithelial cell development (GO:0060576)5.16689718
27GDP-mannose metabolic process (GO:0019673)5.12657841
28ERK1 and ERK2 cascade (GO:0070371)4.98805214
29myoblast fusion (GO:0007520)4.94436934
30regulation of glutamate secretion (GO:0014048)4.88026288
31maternal behavior (GO:0042711)4.83434815
32regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.68279975
33proline metabolic process (GO:0006560)4.66722060
34branching involved in prostate gland morphogenesis (GO:0060442)4.63857130
35glucocorticoid metabolic process (GO:0008211)4.54275039
36syncytium formation by plasma membrane fusion (GO:0000768)4.53697438
37syncytium formation (GO:0006949)4.53207782
38hippo signaling (GO:0035329)4.50371920
39grooming behavior (GO:0007625)4.43903794
40parental behavior (GO:0060746)4.43737768
41sulfur amino acid catabolic process (GO:0000098)4.30922739
42positive regulation of systemic arterial blood pressure (GO:0003084)4.30322099
43negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.28700243
44skin morphogenesis (GO:0043589)4.20251728
45mitotic cell cycle arrest (GO:0071850)4.19055120
46type B pancreatic cell proliferation (GO:0044342)4.15132032
47hormone biosynthetic process (GO:0042446)4.14444235
48protein maturation by protein folding (GO:0022417)4.09086959
49negative regulation of neurological system process (GO:0031645)4.07762973
50vitamin transmembrane transport (GO:0035461)4.06529170
51response to gonadotropin (GO:0034698)4.04200909
52* regulation of gonadotropin secretion (GO:0032276)3.99466393
53regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.99105098
54establishment of apical/basal cell polarity (GO:0035089)3.93602238
55basement membrane organization (GO:0071711)3.90160360
56protein localization to endosome (GO:0036010)3.89043968
57regulation of microtubule-based movement (GO:0060632)3.87174423
58activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.84085121
59vascular endothelial growth factor signaling pathway (GO:0038084)3.78797049
60mitotic cytokinesis (GO:0000281)3.72124031
61anterior/posterior axis specification, embryo (GO:0008595)3.69905480
62hormone catabolic process (GO:0042447)3.69894331
63Golgi transport vesicle coating (GO:0048200)3.64164016
64COPI coating of Golgi vesicle (GO:0048205)3.64164016
65positive regulation of nuclease activity (GO:0032075)3.63965378
66ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.63266518
67positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.62693220
68sprouting angiogenesis (GO:0002040)3.62209043
69maintenance of protein localization in organelle (GO:0072595)3.57344373
70endocrine hormone secretion (GO:0060986)3.54523806
71negative regulation of cholesterol transport (GO:0032375)3.53235159
72negative regulation of sterol transport (GO:0032372)3.53235159
73regulation of fatty acid biosynthetic process (GO:0042304)3.50296127
74vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.47574582
75transcription from mitochondrial promoter (GO:0006390)3.46251683
76regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.46161055
77heme transport (GO:0015886)3.46125237
78mannose metabolic process (GO:0006013)3.46060501
79nucleotide-sugar biosynthetic process (GO:0009226)3.45707765
80prostate gland epithelium morphogenesis (GO:0060740)3.45597243
81sphingoid metabolic process (GO:0046519)3.44849915
82negative regulation of activin receptor signaling pathway (GO:0032926)3.44432228
83intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.37192187
84epithelial cell differentiation involved in prostate gland development (GO:0060742)3.36391000
85establishment of monopolar cell polarity (GO:0061162)3.32600566
86establishment or maintenance of monopolar cell polarity (GO:0061339)3.32600566
87collecting duct development (GO:0072044)3.30488262
88regulation of nuclease activity (GO:0032069)3.30191885
89cytoskeleton-dependent cytokinesis (GO:0061640)3.30177483
90regulation of G0 to G1 transition (GO:0070316)3.30008928
91lymphangiogenesis (GO:0001946)3.28869473
92respiratory system process (GO:0003016)3.27286672
93cellular modified amino acid catabolic process (GO:0042219)3.26874157
94heart trabecula formation (GO:0060347)3.25855001
95regulation of beta-amyloid formation (GO:1902003)3.25424687
96synaptic vesicle docking involved in exocytosis (GO:0016081)3.23932250
97wound healing, spreading of cells (GO:0044319)3.23085873
98lymph vessel development (GO:0001945)3.22831227
99pyrimidine-containing compound transmembrane transport (GO:0072531)3.21703453
100eyelid development in camera-type eye (GO:0061029)3.18405557
101iron coordination entity transport (GO:1901678)3.18295213
102mesodermal cell differentiation (GO:0048333)3.17831159
103prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.17203109
104regulation of translational termination (GO:0006449)3.15849879
105activation of Rac GTPase activity (GO:0032863)3.15742413
106cell-cell junction maintenance (GO:0045217)3.14919594
107response to salt stress (GO:0009651)3.14699239
108JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.13802449
109positive regulation of fatty acid metabolic process (GO:0045923)3.11202486
110endoplasmic reticulum unfolded protein response (GO:0030968)3.07948635
111focal adhesion assembly (GO:0048041)3.07939642
112cell-substrate adherens junction assembly (GO:0007045)3.07939642
113N-glycan processing (GO:0006491)3.06621657
114endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.04894535
115reproductive behavior (GO:0019098)3.03851137
116regulation of early endosome to late endosome transport (GO:2000641)3.02541361
117adherens junction assembly (GO:0034333)3.01070521
118estrogen biosynthetic process (GO:0006703)20.5767525
119cellular response to unfolded protein (GO:0034620)2.99513030
120histone H4-K12 acetylation (GO:0043983)2.99226937
121SMAD protein complex assembly (GO:0007183)2.96275994
122response to gravity (GO:0009629)2.95922506
123negative regulation of catenin import into nucleus (GO:0035414)2.95074809
124cell adhesion mediated by integrin (GO:0033627)2.93908910
125positive regulation of synaptic transmission, GABAergic (GO:0032230)2.93118563
126regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.92434705
127biotin metabolic process (GO:0006768)2.91071849
128response to endoplasmic reticulum stress (GO:0034976)2.90845586
129glandular epithelial cell differentiation (GO:0002067)2.90173774
130artery development (GO:0060840)2.89259475
131epithelial cell maturation (GO:0002070)2.89063237
132labyrinthine layer development (GO:0060711)2.88524605
133cellular response to topologically incorrect protein (GO:0035967)2.86361901
134wound healing, spreading of epidermal cells (GO:0035313)2.85567776
135COPII vesicle coating (GO:0048208)2.84983329
136cell-substrate junction assembly (GO:0007044)2.84325130
137bone morphogenesis (GO:0060349)2.84144995
138valine metabolic process (GO:0006573)2.82679727
139regulation of hippo signaling (GO:0035330)2.82539197
140mitochondrial DNA metabolic process (GO:0032042)2.82497088
141glutamine family amino acid biosynthetic process (GO:0009084)2.81449254
142ER-nucleus signaling pathway (GO:0006984)2.77836408
143DNA unwinding involved in DNA replication (GO:0006268)2.77265946
144cofactor transport (GO:0051181)2.77121645
145positive regulation of osteoblast proliferation (GO:0033690)2.75195566
146ribosome assembly (GO:0042255)2.75027309
147regulation of amino acid transport (GO:0051955)2.74530392
148negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.74332752
149myelin maintenance (GO:0043217)2.74004315
150neuromuscular process controlling posture (GO:0050884)2.73043053
151regulation of amyloid precursor protein catabolic process (GO:1902991)2.72690479
152pinocytosis (GO:0006907)2.71572789
153positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.71558649
154UDP-N-acetylglucosamine metabolic process (GO:0006047)2.69007322
155coenzyme catabolic process (GO:0009109)2.67474796
156multicellular organismal water homeostasis (GO:0050891)2.66932715
157atrioventricular valve morphogenesis (GO:0003181)2.66636351
158establishment of integrated proviral latency (GO:0075713)2.65305160
159potassium ion homeostasis (GO:0055075)2.64571852
160cell junction maintenance (GO:0034331)2.63951680
161polarized epithelial cell differentiation (GO:0030859)2.63637519
162cellular response to ATP (GO:0071318)2.62612314
163activation of Rho GTPase activity (GO:0032862)2.61967836
164ectodermal placode formation (GO:0060788)2.61475028
165UV protection (GO:0009650)2.61246410
166regulation of renal sodium excretion (GO:0035813)2.60576319
167high-density lipoprotein particle remodeling (GO:0034375)2.59773002
168embryonic process involved in female pregnancy (GO:0060136)2.59615061
169regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.59323651
170regulation of protein homooligomerization (GO:0032462)2.58912477
1714-hydroxyproline metabolic process (GO:0019471)2.57716403
172heterochromatin organization (GO:0070828)2.57313709
173negative regulation of cell-matrix adhesion (GO:0001953)2.52421121
174neuronal ion channel clustering (GO:0045161)2.51091025
175regulation of mammary gland epithelial cell proliferation (GO:0033599)2.48601797
176cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.48082803
177positive regulation of protein kinase C signaling (GO:0090037)2.44675210
178positive regulation of cartilage development (GO:0061036)2.43158479
179hemidesmosome assembly (GO:0031581)2.40207303
180trabecula formation (GO:0060343)2.38997398
181positive regulation of epithelial to mesenchymal transition (GO:0010718)2.38058778
182epithelial cell-cell adhesion (GO:0090136)2.37631657
183muscle cell migration (GO:0014812)2.35249372
184membrane raft organization (GO:0031579)2.35081656
185hypotonic response (GO:0006971)2.35030388
186regulation of plasminogen activation (GO:0010755)2.31450160
187positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.30948828
188establishment of viral latency (GO:0019043)2.30389686
189protein neddylation (GO:0045116)2.30271442
190lung vasculature development (GO:0060426)2.30209617
191apoptotic cell clearance (GO:0043277)2.29884653
192positive regulation of DNA-dependent DNA replication (GO:2000105)2.29615619
193positive regulation of blood vessel endothelial cell migration (GO:0043536)2.28320700
194myelin assembly (GO:0032288)2.26171558

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human6.96117193
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.45818827
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.45818827
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.45818827
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.32735185
6ESR1_15608294_ChIP-ChIP_MCF-7_Human3.24034882
7POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.09353907
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.97743139
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.93981794
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.89895261
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.80840455
12SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.78709095
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.70820993
14EGR1_19032775_ChIP-ChIP_M12_Human2.63683706
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.62306059
16ERG_21242973_ChIP-ChIP_JURKAT_Human2.61257384
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.61184845
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.53348205
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.51909891
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.50388570
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.41990886
22CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.27158504
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27095022
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.26500512
25* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.16754344
26JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.13679872
27RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.13549483
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.11666354
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.09726360
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.09726360
31AR_21909140_ChIP-Seq_LNCAP_Human2.08826366
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06723997
33ZFP281_18757296_ChIP-ChIP_E14_Mouse2.01412472
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97340496
35TCF3_18692474_ChIP-Seq_MEFs_Mouse1.97179899
36TCF3_18692474_ChIP-Seq_MESCs_Mouse1.95984902
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.95571965
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.94030538
39KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.92890283
40BRD4_25478319_ChIP-Seq_HGPS_Human1.92766408
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.91885940
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.91138689
43* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.86491654
44* RXR_22158963_ChIP-Seq_LIVER_Mouse1.83931960
45ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.81608599
46* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.78120685
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76290840
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76088352
49P63_26484246_Chip-Seq_KERATINOCYTES_Human1.73604075
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73363443
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73069629
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.70670098
53* UBF1/2_26484160_Chip-Seq_HMECs_Human1.70339962
54NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.67345751
55CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.65605043
56POU5F1_16518401_ChIP-PET_MESCs_Mouse1.65234437
57LXR_22292898_ChIP-Seq_THP-1_Human1.61103003
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61050213
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61003211
60CLOCK_20551151_ChIP-Seq_293T_Human1.60933818
61* TET1_21451524_ChIP-Seq_MESCs_Mouse1.58130832
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.49140564
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.49050691
64NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.48623937
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.48439991
66EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.47369032
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47166000
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44833212
69ZNF263_19887448_ChIP-Seq_K562_Human1.43339669
70OCT4_18692474_ChIP-Seq_MEFs_Mouse1.42737935
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.42162503
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.39774780
73RACK7_27058665_Chip-Seq_MCF-7_Human1.39228404
74POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.38942828
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37121018
76SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37018602
77FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.36833906
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36732002
79* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36364331
80FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.36198421
81CREB1_26743006_Chip-Seq_LNCaP_Human1.35307095
82EGR1_19374776_ChIP-ChIP_THP-1_Human1.35029470
83LXR_22158963_ChIP-Seq_LIVER_Mouse1.33406922
84NANOG_18692474_ChIP-Seq_MESCs_Mouse1.32824051
85SOX2_18692474_ChIP-Seq_MEFs_Mouse1.32717681
86SOX2_18692474_ChIP-Seq_MESCs_Mouse1.32193814
87* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32146038
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31197537
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30481844
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30169744
91JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30019709
92NANOG_18692474_ChIP-Seq_MEFs_Mouse1.28890508
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27870135
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27766128
95* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27760218
96* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26449668
97CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25480158
98RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24925639
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24825254
100SMC4_20622854_ChIP-Seq_HELA_Human1.24796620
101KAP1_27257070_Chip-Seq_ESCs_Mouse1.22988054
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21568052
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20808128
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18213844
105ELF1_20517297_ChIP-Seq_JURKAT_Human1.17491761
106RARB_24833708_ChIP-Seq_LIVER_Mouse1.17330817
107ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16284137
108* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15673595
109GATA2_21666600_ChIP-Seq_HMVEC_Human1.14803006
110MYC_22102868_ChIP-Seq_BL_Human1.14330581
111RARA_24833708_ChIP-Seq_LIVER_Mouse1.14092299
112SPI1_26923725_Chip-Seq_HPCs_Mouse1.13931407
113STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12762903
114PHF8_20622854_ChIP-Seq_HELA_Human1.12722533
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12521441
116KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12481310
117TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.12314748
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11454008
119SMC1_22415368_ChIP-Seq_MEFs_Mouse1.11322250
120YY1_22570637_ChIP-Seq_MALME-3M_Human1.10327286
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08208307
122PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.08197133
123TP53_18474530_ChIP-ChIP_U2OS_Human1.08043223
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07640165
125NANOG_16518401_ChIP-PET_MESCs_Mouse1.07057448
126POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06584309
127PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06433964
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05944490
129BCOR_27268052_Chip-Seq_Bcells_Human1.05675321
130KDM2B_26808549_Chip-Seq_K562_Human1.05527331
131TP53_22127205_ChIP-Seq_IMR90_Human1.05291882
132VDR_21846776_ChIP-Seq_THP-1_Human1.05285838
133DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04284382
134CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03410468
135TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02400368
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02077626
137ELK1_22589737_ChIP-Seq_MCF10A_Human1.01910084
138CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01493659
139ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00808791
140MYC_18555785_ChIP-Seq_MESCs_Mouse0.99701446
141SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99382845
142P68_20966046_ChIP-Seq_HELA_Human0.99183310
143E2F7_22180533_ChIP-Seq_HELA_Human0.99160618
144GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.98789207
145RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97877711
146XRN2_22483619_ChIP-Seq_HELA_Human0.97746114
147SOX17_20123909_ChIP-Seq_XEN_Mouse0.97735437
148DCP1A_22483619_ChIP-Seq_HELA_Human0.97700989
149NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97415771
150ATF3_27146783_Chip-Seq_COLON_Human0.97344683
151NELFA_20434984_ChIP-Seq_ESCs_Mouse0.96752448
152TFEB_21752829_ChIP-Seq_HELA_Human0.96163512
153FOXO3_23340844_ChIP-Seq_DLD1_Human0.96137740
154SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95721373
155THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95270921
156KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95260944
157ESR1_21235772_ChIP-Seq_MCF-7_Human0.95014632
158FOXP1_21924763_ChIP-Seq_HESCs_Human0.94512219
159MYC_19030024_ChIP-ChIP_MESCs_Mouse0.94398634
160CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93627967
161NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93008383
162MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92892683
163TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92488059
164IRF1_19129219_ChIP-ChIP_H3396_Human0.92448432
165TET1_21490601_ChIP-Seq_MESCs_Mouse0.92240007
166POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92097076
167YY1_21170310_ChIP-Seq_MESCs_Mouse0.91623400
168SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91479412
169RUNX1_27514584_Chip-Seq_MCF-7_Human0.91369461
170CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89332666
171TBX20_22080862_ChIP-Seq_HEART_Mouse0.88927770
172TBX20_22328084_ChIP-Seq_HEART_Mouse0.88927770
173SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86266866
174CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85803562
175SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85217150

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation8.39168504
2MP0005645_abnormal_hypothalamus_physiol7.18191972
3MP0003283_abnormal_digestive_organ4.10006608
4MP0010368_abnormal_lymphatic_system4.01707943
5MP0004043_abnormal_pH_regulation3.86599627
6MP0003950_abnormal_plasma_membrane3.54578448
7MP0004264_abnormal_extraembryonic_tissu3.40556622
8MP0003122_maternal_imprinting3.24843514
9MP0002653_abnormal_ependyma_morphology3.07665958
10MP0005365_abnormal_bile_salt2.99758501
11MP0003566_abnormal_cell_adhesion2.95294118
12MP0002139_abnormal_hepatobiliary_system2.87372673
13MP0003941_abnormal_skin_development2.83601732
14MP0008961_abnormal_basal_metabolism2.60475966
15MP0001348_abnormal_lacrimal_gland2.58757178
16MP0005257_abnormal_intraocular_pressure2.58739460
17MP0005647_abnormal_sex_gland2.49640012
18MP0004272_abnormal_basement_membrane2.48048234
19MP0004510_myositis2.40614678
20MP0000013_abnormal_adipose_tissue2.37872447
21MP0005310_abnormal_salivary_gland2.36634864
22MP0010234_abnormal_vibrissa_follicle2.32644382
23MP0006276_abnormal_autonomic_nervous2.26797616
24MP0005023_abnormal_wound_healing2.14441333
25MP0002909_abnormal_adrenal_gland2.13914452
26MP0003123_paternal_imprinting2.09242436
27MP0003453_abnormal_keratinocyte_physiol1.99242541
28MP0001919_abnormal_reproductive_system1.94134318
29MP0005058_abnormal_lysosome_morphology1.83457610
30MP0005375_adipose_tissue_phenotype1.77255545
31MP0001958_emphysema1.74579739
32MP0003890_abnormal_embryonic-extraembry1.67829825
33MP0008438_abnormal_cutaneous_collagen1.65316772
34MP0003183_abnormal_peptide_metabolism1.59785876
35MP0002877_abnormal_melanocyte_morpholog1.59302178
36MP0005332_abnormal_amino_acid1.57816005
37MP0000751_myopathy1.56476842
38MP0006138_congestive_heart_failure1.54966733
39MP0003091_abnormal_cell_migration1.52562735
40MP0004185_abnormal_adipocyte_glucose1.50387715
41MP0001756_abnormal_urination1.48311667
42MP0009053_abnormal_anal_canal1.48149833
43MP0002166_altered_tumor_susceptibility1.47835689
44MP0005085_abnormal_gallbladder_physiolo1.46207390
45MP0003121_genomic_imprinting1.44532096
46MP0009840_abnormal_foam_cell1.43699991
47MP0002254_reproductive_system_inflammat1.40771798
48MP0006072_abnormal_retinal_apoptosis1.39040421
49MP0005451_abnormal_body_composition1.37730265
50MP0002009_preneoplasia1.37016565
51MP0009115_abnormal_fat_cell1.35432930
52MP0009379_abnormal_foot_pigmentation1.35083191
53MP0000750_abnormal_muscle_regeneration1.34754695
54MP0003656_abnormal_erythrocyte_physiolo1.34613999
55MP0004133_heterotaxia1.33561155
56MP0004858_abnormal_nervous_system1.32132845
57MP0001502_abnormal_circadian_rhythm1.29661952
58MP0002132_abnormal_respiratory_system1.26671971
59MP0003137_abnormal_impulse_conducting1.25423650
60* MP0000613_abnormal_salivary_gland1.23416773
61MP0004885_abnormal_endolymph1.22779969
62MP0006292_abnormal_olfactory_placode1.22564174
63MP0003300_gastrointestinal_ulcer1.22254627
64MP0006054_spinal_hemorrhage1.21995547
65MP0001879_abnormal_lymphatic_vessel1.19583273
66MP0002060_abnormal_skin_morphology1.19468610
67MP0002998_abnormal_bone_remodeling1.18262695
68MP0003705_abnormal_hypodermis_morpholog1.18048677
69MP0004859_abnormal_synaptic_plasticity1.16944779
70MP0008875_abnormal_xenobiotic_pharmacok1.16201020
71MP0001765_abnormal_ion_homeostasis1.15420125
72MP0000733_abnormal_muscle_development1.15178735
73MP0000749_muscle_degeneration1.13855131
74MP0000759_abnormal_skeletal_muscle1.12876283
75MP0004957_abnormal_blastocyst_morpholog1.12809824
76MP0005319_abnormal_enzyme/_coenzyme1.10305441
77MP0002269_muscular_atrophy1.09717045
78MP0003119_abnormal_digestive_system1.09541011
79MP0009703_decreased_birth_body1.08741611
80MP0001440_abnormal_grooming_behavior1.08469843
81MP0001340_abnormal_eyelid_morphology1.07379782
82MP0003959_abnormal_lean_body1.05479081
83MP0005636_abnormal_mineral_homeostasis1.04462709
84MP0009643_abnormal_urine_homeostasis1.03666313
85MP0002006_tumorigenesis1.00352986
86MP0002128_abnormal_blood_circulation0.99139909
87MP0002089_abnormal_postnatal_growth/wei0.97832806
88MP0003385_abnormal_body_wall0.97808728
89MP0004947_skin_inflammation0.97756513
90MP0005501_abnormal_skin_physiology0.96911049
91* MP0000639_abnormal_adrenal_gland0.96807619
92MP0005389_reproductive_system_phenotype0.96780681
93MP0001730_embryonic_growth_arrest0.94914400
94MP0005220_abnormal_exocrine_pancreas0.94900842
95MP0002733_abnormal_thermal_nociception0.93949421
96MP0010329_abnormal_lipoprotein_level0.93451832
97MP0008057_abnormal_DNA_replication0.93069602
98MP0000609_abnormal_liver_physiology0.92604906
99MP0010352_gastrointestinal_tract_polyps0.92526379
100MP0000003_abnormal_adipose_tissue0.91131081
101MP0001243_abnormal_dermal_layer0.90575830
102MP0004019_abnormal_vitamin_homeostasis0.90513514
103MP0001944_abnormal_pancreas_morphology0.90333650
104MP0003787_abnormal_imprinting0.88925835
105MP0002078_abnormal_glucose_homeostasis0.88637844
106MP0002069_abnormal_eating/drinking_beha0.88367881
107MP0003953_abnormal_hormone_level0.88084750
108MP0005360_urolithiasis0.87657421
109MP0002332_abnormal_exercise_endurance0.87209920
110MP0010386_abnormal_urinary_bladder0.86812372
111MP0001661_extended_life_span0.85487979
112MP0005623_abnormal_meninges_morphology0.85459399
113MP0005266_abnormal_metabolism0.85360975
114MP0000858_altered_metastatic_potential0.84724720
115MP0001672_abnormal_embryogenesis/_devel0.84705273
116MP0005380_embryogenesis_phenotype0.84705273
117MP0002086_abnormal_extraembryonic_tissu0.84004630
118MP0009672_abnormal_birth_weight0.83842297
119MP0005330_cardiomyopathy0.82113048
120MP0001970_abnormal_pain_threshold0.81923378
121MP0010030_abnormal_orbit_morphology0.81448230
122MP0002084_abnormal_developmental_patter0.81079958
123MP0002971_abnormal_brown_adipose0.80671608
124MP0002184_abnormal_innervation0.80146035
125MP0003111_abnormal_nucleus_morphology0.80057640
126MP0000462_abnormal_digestive_system0.80010254
127MP0001915_intracranial_hemorrhage0.78763652
128MP0003638_abnormal_response/metabolism_0.76818000
129MP0002085_abnormal_embryonic_tissue0.76414361
130MP0000762_abnormal_tongue_morphology0.76023660
131MP0003718_maternal_effect0.75627900
132MP0003806_abnormal_nucleotide_metabolis0.75503466
133MP0002796_impaired_skin_barrier0.75129441
134MP0002295_abnormal_pulmonary_circulatio0.75010662
135MP0002111_abnormal_tail_morphology0.74746876
136MP0003448_altered_tumor_morphology0.73894455
137MP0001216_abnormal_epidermal_layer0.73648266
138MP0000678_abnormal_parathyroid_gland0.73390325
139MP0009780_abnormal_chondrocyte_physiolo0.73307527
140MP0000767_abnormal_smooth_muscle0.73096506
141MP0003045_fibrosis0.72409023
142MP0003191_abnormal_cellular_cholesterol0.71953725
143MP0003795_abnormal_bone_structure0.71397592
144MP0000350_abnormal_cell_proliferation0.71151740
145MP0002925_abnormal_cardiovascular_devel0.71047826
146MP0000747_muscle_weakness0.69898896
147MP0005197_abnormal_uvea_morphology0.69427420
148MP0000955_abnormal_spinal_cord0.69161722
149MP0003279_aneurysm0.68554900
150MP0005076_abnormal_cell_differentiation0.68472233
151MP0005621_abnormal_cell_physiology0.68397484
152MP0002970_abnormal_white_adipose0.67793207
153MP0004233_abnormal_muscle_weight0.67619769
154* MP0005379_endocrine/exocrine_gland_phen0.67043699
155MP0002102_abnormal_ear_morphology0.66685352
156MP0003077_abnormal_cell_cycle0.66677711
157MP0000537_abnormal_urethra_morphology0.66373741
158MP0004087_abnormal_muscle_fiber0.65715878
159MP0002075_abnormal_coat/hair_pigmentati0.65367168
160MP0005193_abnormal_anterior_eye0.65299127
161MP0002972_abnormal_cardiac_muscle0.65188666
162MP0002118_abnormal_lipid_homeostasis0.65082259
163MP0001697_abnormal_embryo_size0.64953475
164MP0000534_abnormal_ureter_morphology0.64763724
165MP0005423_abnormal_somatic_nervous0.64737949
166MP0003252_abnormal_bile_duct0.63078903
167MP0002088_abnormal_embryonic_growth/wei0.62442142
168MP0004197_abnormal_fetal_growth/weight/0.62396391
169MP0001614_abnormal_blood_vessel0.61885482
170MP0005165_increased_susceptibility_to0.61200661
171MP0000358_abnormal_cell_content/0.59517986
172MP0002080_prenatal_lethality0.59397773
173MP0003984_embryonic_growth_retardation0.58945526

Predicted human phenotypes

RankGene SetZ-score
1Upper limb muscle weakness (HP:0003484)5.34682137
2Abnormality of the lower motor neuron (HP:0002366)4.78364081
3Hypergonadotropic hypogonadism (HP:0000815)4.70628138
4Capillary hemangiomas (HP:0005306)4.67578269
5Shawl scrotum (HP:0000049)4.44144381
6Decreased number of large peripheral myelinated nerve fibers (HP:0003387)4.38067649
7Abnormality of cochlea (HP:0000375)4.23229341
8Long palpebral fissure (HP:0000637)3.90576500
9Hyperinsulinemic hypoglycemia (HP:0000825)3.89215267
10Hyperglycinuria (HP:0003108)3.81960047
11Protrusio acetabuli (HP:0003179)3.76002211
12Vertebral compression fractures (HP:0002953)3.73073988
13Hypoglycemic seizures (HP:0002173)3.64693318
14Abnormal pupillary function (HP:0007686)3.56512722
15Abnormality of the intrinsic pathway (HP:0010989)3.54247483
16Fragile skin (HP:0001030)3.52927316
17Abnormal auditory evoked potentials (HP:0006958)3.51743419
18Premature rupture of membranes (HP:0001788)3.49933348
19Hypochromic microcytic anemia (HP:0004840)3.46609577
20Back pain (HP:0003418)3.41012356
21Failure to thrive in infancy (HP:0001531)3.39263949
22Nonimmune hydrops fetalis (HP:0001790)3.35614884
23Cerebral aneurysm (HP:0004944)3.31992684
24Turricephaly (HP:0000262)3.27708690
25Gout (HP:0001997)3.26056508
26Short humerus (HP:0005792)3.23819283
27Distal lower limb muscle weakness (HP:0009053)3.19897960
28Male infertility (HP:0003251)3.18207811
29Diaphragmatic weakness (HP:0009113)3.17098209
30Aplasia/hypoplasia of the humerus (HP:0006507)3.15525645
31Morphological abnormality of the inner ear (HP:0011390)3.15291770
32Entropion (HP:0000621)3.12376720
33Distal lower limb amyotrophy (HP:0008944)3.10464348
34Vaginal fistula (HP:0004320)3.02163038
35Breast hypoplasia (HP:0003187)2.94294619
36Rectovaginal fistula (HP:0000143)2.94260095
37Rectal fistula (HP:0100590)2.94260095
38Testicular atrophy (HP:0000029)2.92827476
39Ependymoma (HP:0002888)2.91670291
40Wormian bones (HP:0002645)2.90127972
41Rib fusion (HP:0000902)2.87555962
42Progressive muscle weakness (HP:0003323)2.86007706
43Growth hormone excess (HP:0000845)2.85595903
44Abnormality of endocrine pancreas physiology (HP:0012093)2.82731889
45Abnormality of the pancreatic islet cells (HP:0006476)2.82731889
46Symptomatic seizures (HP:0011145)2.81691134
47Cardiovascular calcification (HP:0011915)2.80907884
48Disproportionate tall stature (HP:0001519)2.80333703
49Dysostosis multiplex (HP:0000943)2.78353306
50Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.78161360
51Abnormality of serine family amino acid metabolism (HP:0010894)2.76269649
52Abnormality of glycine metabolism (HP:0010895)2.76269649
53Dysautonomia (HP:0002459)2.75724967
54Ketoacidosis (HP:0001993)2.75300033
55Hyperacusis (HP:0010780)2.75112413
56Increased connective tissue (HP:0009025)2.71814180
57Hand muscle atrophy (HP:0009130)2.70145538
58Wide nose (HP:0000445)2.69725873
59Spinal muscular atrophy (HP:0007269)2.64072273
60Reduced subcutaneous adipose tissue (HP:0003758)2.63709085
61Trismus (HP:0000211)2.63618881
62Abnormality of the labia minora (HP:0012880)2.63249396
63Vascular calcification (HP:0004934)2.60163292
64Osteolytic defects of the hand bones (HP:0009699)2.59733104
65Osteolytic defects of the phalanges of the hand (HP:0009771)2.59733104
66Intestinal fistula (HP:0100819)2.58358401
67Pancreatic islet-cell hyperplasia (HP:0004510)2.57618965
68Hyperglycinemia (HP:0002154)2.55488950
69Poikiloderma (HP:0001029)2.52890846
70Abnormality of the distal phalanges of the toes (HP:0010182)2.50429343
71Restlessness (HP:0000711)2.50151672
72Multiple enchondromatosis (HP:0005701)2.44157016
73Decreased subcutaneous fat (HP:0001002)2.41922667
74Elbow flexion contracture (HP:0002987)2.40645545
75Hyperglycemia (HP:0003074)2.37339647
76Accelerated skeletal maturation (HP:0005616)2.37014798
77Aortic aneurysm (HP:0004942)2.36843113
78Arterial tortuosity (HP:0005116)2.34385962
79Abnormality of the astrocytes (HP:0100707)2.33379779
80Astrocytoma (HP:0009592)2.33379779
81Ulnar bowing (HP:0003031)2.32396016
82Macroorchidism (HP:0000053)2.31822977
83Rectal prolapse (HP:0002035)2.30990738
84Atrophic scars (HP:0001075)2.29840964
85Tetraplegia (HP:0002445)2.29562571
86Concave nail (HP:0001598)2.29088695
87Retinal atrophy (HP:0001105)2.29011638
88Hyperparathyroidism (HP:0000843)2.24921849
89Blue sclerae (HP:0000592)2.23707622
90Urinary glycosaminoglycan excretion (HP:0003541)2.22648562
91Mucopolysacchariduria (HP:0008155)2.22648562
92Hypoglycemic coma (HP:0001325)2.22332765
93Tongue fasciculations (HP:0001308)2.21847172
94Ketosis (HP:0001946)2.20957126
95Pustule (HP:0200039)2.20799560
96Female pseudohermaphroditism (HP:0010458)2.20668936
97Neoplasm of the heart (HP:0100544)2.19144424
98Vascular tortuosity (HP:0004948)2.18822186
99Congenital ichthyosiform erythroderma (HP:0007431)2.18739941
100Tetraparesis (HP:0002273)2.18054498
101Hypercortisolism (HP:0001578)2.17396673
102Widely patent fontanelles and sutures (HP:0004492)2.16964637
103Bilateral sensorineural hearing impairment (HP:0008619)2.15642542
104Delayed puberty (HP:0000823)2.14667379
105Short nail (HP:0001799)2.13906069
106Status epilepticus (HP:0002133)2.13696392
107Kyphoscoliosis (HP:0002751)2.12920395
108Fasciculations (HP:0002380)2.11576529
109Aortic dissection (HP:0002647)2.09985754
110Aplasia of the musculature (HP:0100854)2.07549919
111Long eyelashes (HP:0000527)2.06359516
112Hypoplastic nipples (HP:0002557)2.05837456
113Alopecia of scalp (HP:0002293)2.05171179
114Exocrine pancreatic insufficiency (HP:0001738)2.04536558
115Abnormality of the Achilles tendon (HP:0005109)2.04081917
116Aneurysm (HP:0002617)2.03658097
117EMG: neuropathic changes (HP:0003445)2.03267780
118Delayed gross motor development (HP:0002194)2.02766896
119Lower limb amyotrophy (HP:0007210)2.02698143
120Upper limb amyotrophy (HP:0009129)2.01740298
121Distal upper limb amyotrophy (HP:0007149)2.01740298
122Hepatoblastoma (HP:0002884)2.01203409
123Achilles tendon contracture (HP:0001771)2.01025699
124Muscle fibrillation (HP:0010546)2.00844064
125Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.00341123
126Thin ribs (HP:0000883)2.00076242
127Genu valgum (HP:0002857)1.99958275
128Large for gestational age (HP:0001520)1.99807361
129Vertebral hypoplasia (HP:0008417)1.98182461
130Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.98182461
131Facial shape deformation (HP:0011334)1.97523161
132Potter facies (HP:0002009)1.97523161
133Shallow orbits (HP:0000586)1.94667862
134Abnormal neuron morphology (HP:0012757)1.94237734
135Abnormality of the motor neurons (HP:0002450)1.94237734
136Long toe (HP:0010511)1.93954032
137Agitation (HP:0000713)1.93514062
138Nail dystrophy (HP:0008404)1.92550855
139Deviation of the thumb (HP:0009603)1.91556629
140Abnormality of aromatic amino acid family metabolism (HP:0004338)1.91064734
141Sparse lateral eyebrow (HP:0005338)1.90876087
142Intention tremor (HP:0002080)1.90395686
143Areflexia of lower limbs (HP:0002522)1.90242872
144Coxa vara (HP:0002812)1.90191330
145Knee flexion contracture (HP:0006380)1.86615380
146Brittle hair (HP:0002299)1.85710288
147Round ear (HP:0100830)1.85379314
148Spinal rigidity (HP:0003306)1.84595541
149Orthostatic hypotension (HP:0001278)1.84584367
150Mitral regurgitation (HP:0001653)1.84457982
151Difficulty climbing stairs (HP:0003551)1.84436460
152Abnormality of polysaccharide metabolism (HP:0011012)1.83367109
153Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83367109
154Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83367109
155Impaired pain sensation (HP:0007328)1.80773931
156Abnormality of pain sensation (HP:0010832)1.80773931
157Abnormality of subcutaneous fat tissue (HP:0001001)1.78914343
158Bilateral microphthalmos (HP:0007633)1.77486303
159Broad face (HP:0000283)1.77357236
160Abnormality of the musculature of the hand (HP:0001421)1.76651150
161Limb-girdle muscle atrophy (HP:0003797)1.76075554
162Abnormality of monocarboxylic acid metabolism (HP:0010996)1.74552716
163Insulin resistance (HP:0000855)1.74352831
164Hypotension (HP:0002615)1.74112227
165Irritability (HP:0000737)1.73985305
166Focal segmental glomerulosclerosis (HP:0000097)1.73716539
167Abnormality of the axillary hair (HP:0100134)1.73008256
168Abnormality of secondary sexual hair (HP:0009888)1.73008256
169Abnormality of the salivary glands (HP:0010286)1.72770136
170Oligomenorrhea (HP:0000876)1.72728083
171Abnormality of the distal phalanx of the thumb (HP:0009617)1.72057112
172Mitral stenosis (HP:0001718)1.71754676
173Gynecomastia (HP:0000771)1.71452276
174Fragile nails (HP:0001808)1.70906296
175Ankle contracture (HP:0006466)1.70492168
176Muscle fiber splitting (HP:0003555)1.70394437
177Ileus (HP:0002595)1.69840874
178Axonal loss (HP:0003447)1.69409300
179Polycythemia (HP:0001901)1.68723738
180Onion bulb formation (HP:0003383)1.68604870
181Bicuspid aortic valve (HP:0001647)1.67846957
182Mildly elevated creatine phosphokinase (HP:0008180)1.67729716
183Dilatation of the ascending aorta (HP:0005111)1.63947128
184Prominent metopic ridge (HP:0005487)1.62184925
185Short clavicles (HP:0000894)1.61044523
186Upper motor neuron abnormality (HP:0002127)1.60898537
187Arachnodactyly (HP:0001166)1.60477943
188Aplasia cutis congenita (HP:0001057)1.60420470

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT36.97691206
2KDR5.28559223
3ERN14.32371215
4MAPK154.20295038
5ICK3.03289298
6IRAK32.98787778
7SMG12.80940564
8DDR22.53548198
9EPHA22.51962160
10NME22.42837068
11MST1R2.34021315
12PINK12.25289806
13FRK2.12432256
14MET1.99943246
15TYRO31.96509371
16MOS1.96284973
17WNK31.88370453
18UHMK11.80826480
19TAOK31.77055819
20MATK1.76724226
21GRK51.71251188
22PAK41.70760566
23BCKDK1.68266566
24LATS21.67391191
25CDK121.66498424
26PDGFRA1.61801854
27ERBB41.48067482
28DYRK1B1.44372922
29TRIB31.42151605
30NTRK11.40288539
31MAPKAPK31.39471088
32TESK11.38564271
33INSRR1.37205583
34TGFBR21.36289568
35EPHB21.32347664
36BRAF1.32039697
37VRK21.30454567
38MAP3K91.25915936
39EPHB11.23771937
40PKN11.22917668
41BMX1.21977742
42PDGFRB1.20596468
43MAP3K111.20505962
44SIK11.19870431
45TLK11.18129546
46SCYL21.15610825
47DAPK11.14885183
48HIPK21.10504851
49MYLK1.09414727
50TAOK11.07297294
51MST41.05798915
52DAPK31.05794333
53CDC42BPA1.03338096
54BRSK21.02463410
55EEF2K1.01296519
56NTRK31.00705980
57TTN1.00233688
58CSK1.00102269
59ABL20.98991349
60PRKCI0.98227880
61RPS6KB20.97216663
62PDK20.96771702
63LATS10.96509340
64LIMK10.96183852
65GRK60.96056145
66ILK0.92643898
67MAP3K20.91140343
68PRKD20.89997149
69ALK0.89940417
70STK380.89460684
71DMPK0.88988710
72MTOR0.88774428
73PTK2B0.85474311
74MAP2K30.84015954
75PDPK10.82423158
76TAOK20.81417752
77LMTK20.80382418
78RIPK10.79546713
79BLK0.73653198
80PAK30.72842120
81PIK3CG0.72722589
82PTK20.72379231
83AURKB0.71670467
84GRK10.71280440
85DAPK20.69760632
86MAP3K80.69694684
87CDK80.69664752
88MAP2K20.68498000
89MAP3K60.66164842
90PHKG20.66117350
91PHKG10.66117350
92TAF10.65662519
93RPS6KA20.65368273
94PRKD30.65095273
95PRKAA10.64834890
96PAK60.64573244
97FGR0.63874274
98NEK90.63016049
99ZAK0.61759846
100VRK10.61081921
101BRSK10.60593242
102PLK10.60107596
103TNK20.59947388
104RPS6KC10.58565083
105RPS6KL10.58565083
106NEK10.58020308
107STK100.57448173
108CDK70.56109424
109CDK190.54227808
110CSF1R0.53971713
111NTRK20.53596621
112WEE10.52578900
113PDK40.52569002
114PDK30.52569002
115ROCK10.51565005
116PAK10.50932549
117GSK3A0.50588874
118KSR20.50511129
119SGK30.48442316
120IRAK20.47892893
121TTK0.45696618
122PASK0.45426351
123AURKA0.44476197
124JAK20.44238316
125CSNK1E0.43753388
126ADRBK20.43475110
127PTK60.43357689
128SIK30.43293861
129AKT20.43213390
130MARK20.43088418
131MAP3K130.42287262
132PAK20.41081201
133MAPK70.40712289
134MAP3K120.40286857
135DYRK30.40235296
136CAMK2G0.39656934
137YES10.39288727
138PIM20.39188011
139RPS6KA10.39089489
140TESK20.39018418
141CHEK20.38812959
142MAPK100.37555138
143ARAF0.37264192
144MAP3K30.36902586
145ROCK20.36546178
146ERBB20.36543930
147RPS6KA60.36417933
148FLT30.34860069
149TSSK60.34822072
150BUB10.34694898
151PRKG20.33646641
152GRK70.32842957
153WNK10.31451899
154NEK20.30519230
155STK40.30217174
156MELK0.29801841
157RPS6KA30.29269751
158PDK10.28266519
159EIF2AK20.27225608

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.73930308
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.45905736
3Vitamin B6 metabolism_Homo sapiens_hsa007504.13317128
4Steroid hormone biosynthesis_Homo sapiens_hsa001403.68354774
5Maturity onset diabetes of the young_Homo sapiens_hsa049503.14910035
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.01752862
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.90234326
8Fructose and mannose metabolism_Homo sapiens_hsa000512.85887007
9Arginine biosynthesis_Homo sapiens_hsa002202.39293431
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.37028132
11Galactose metabolism_Homo sapiens_hsa000522.17615088
12Folate biosynthesis_Homo sapiens_hsa007902.08728866
13Focal adhesion_Homo sapiens_hsa045102.04869903
14Jak-STAT signaling pathway_Homo sapiens_hsa046302.04150782
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.99014836
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.91738043
17Sulfur relay system_Homo sapiens_hsa041221.87414698
18Protein export_Homo sapiens_hsa030601.80141287
19Arginine and proline metabolism_Homo sapiens_hsa003301.76710436
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.75051370
21PI3K-Akt signaling pathway_Homo sapiens_hsa041511.74953949
22Chronic myeloid leukemia_Homo sapiens_hsa052201.71616888
23Nucleotide excision repair_Homo sapiens_hsa034201.64947053
24mTOR signaling pathway_Homo sapiens_hsa041501.60797717
25Fatty acid biosynthesis_Homo sapiens_hsa000611.57437724
26Nitrogen metabolism_Homo sapiens_hsa009101.57207487
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56531993
28Vibrio cholerae infection_Homo sapiens_hsa051101.54299094
29Small cell lung cancer_Homo sapiens_hsa052221.51412168
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49361804
31Biosynthesis of amino acids_Homo sapiens_hsa012301.48504563
32Adherens junction_Homo sapiens_hsa045201.47911265
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47639507
34Renal cell carcinoma_Homo sapiens_hsa052111.44711115
35GABAergic synapse_Homo sapiens_hsa047271.44491049
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35998974
37Viral carcinogenesis_Homo sapiens_hsa052031.34659352
38ECM-receptor interaction_Homo sapiens_hsa045121.34638660
39Proteoglycans in cancer_Homo sapiens_hsa052051.34580899
40Synaptic vesicle cycle_Homo sapiens_hsa047211.33303278
41Sulfur metabolism_Homo sapiens_hsa009201.31843437
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28720741
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28632659
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.26807367
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24375943
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.22724428
47Sphingolipid metabolism_Homo sapiens_hsa006001.22451200
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19760234
49Pancreatic cancer_Homo sapiens_hsa052121.18248243
50Tryptophan metabolism_Homo sapiens_hsa003801.16406599
51Bladder cancer_Homo sapiens_hsa052191.15051289
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14857357
53Regulation of actin cytoskeleton_Homo sapiens_hsa048101.14676567
54Endocytosis_Homo sapiens_hsa041441.12915589
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12583073
56Alcoholism_Homo sapiens_hsa050341.09930472
57Apoptosis_Homo sapiens_hsa042101.08344223
58Longevity regulating pathway - mammal_Homo sapiens_hsa042111.07574500
59Insulin secretion_Homo sapiens_hsa049111.07509440
60Shigellosis_Homo sapiens_hsa051311.03500235
61Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03009999
62Cell cycle_Homo sapiens_hsa041101.02706446
63N-Glycan biosynthesis_Homo sapiens_hsa005101.01668039
64ABC transporters_Homo sapiens_hsa020101.01048613
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00908296
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00787435
67Pyrimidine metabolism_Homo sapiens_hsa002400.99052270
68Systemic lupus erythematosus_Homo sapiens_hsa053220.97755904
69Starch and sucrose metabolism_Homo sapiens_hsa005000.95609726
70Other glycan degradation_Homo sapiens_hsa005110.95417626
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94203362
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93302276
73p53 signaling pathway_Homo sapiens_hsa041150.93265558
74Circadian rhythm_Homo sapiens_hsa047100.93198837
75Collecting duct acid secretion_Homo sapiens_hsa049660.93009828
76Bile secretion_Homo sapiens_hsa049760.92210562
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90926181
78Proteasome_Homo sapiens_hsa030500.90559392
79Prion diseases_Homo sapiens_hsa050200.88987942
80DNA replication_Homo sapiens_hsa030300.87587019
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87086590
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.86699630
83Lysosome_Homo sapiens_hsa041420.86514032
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.86484914
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85948172
86Amoebiasis_Homo sapiens_hsa051460.84897423
87Dilated cardiomyopathy_Homo sapiens_hsa054140.82048186
88Spliceosome_Homo sapiens_hsa030400.79974976
89Thyroid hormone synthesis_Homo sapiens_hsa049180.78312353
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.77517567
91Fatty acid metabolism_Homo sapiens_hsa012120.77434642
92Ras signaling pathway_Homo sapiens_hsa040140.76998781
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.76397343
94Non-small cell lung cancer_Homo sapiens_hsa052230.76384553
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75355440
96Cocaine addiction_Homo sapiens_hsa050300.74547924
97Pathways in cancer_Homo sapiens_hsa052000.74176457
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73886690
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73782319
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73589437
101Butanoate metabolism_Homo sapiens_hsa006500.73517032
102MicroRNAs in cancer_Homo sapiens_hsa052060.72834386
103AMPK signaling pathway_Homo sapiens_hsa041520.72198008
104Amphetamine addiction_Homo sapiens_hsa050310.71650177
105Fat digestion and absorption_Homo sapiens_hsa049750.71266160
106Rap1 signaling pathway_Homo sapiens_hsa040150.70642393
107Salmonella infection_Homo sapiens_hsa051320.69527556
108Melanoma_Homo sapiens_hsa052180.69193415
109Glioma_Homo sapiens_hsa052140.68994575
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68864955
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.68228173
112Hippo signaling pathway_Homo sapiens_hsa043900.67659459
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66822661
114HTLV-I infection_Homo sapiens_hsa051660.66621912
115Selenocompound metabolism_Homo sapiens_hsa004500.65312415
116Tight junction_Homo sapiens_hsa045300.63568193
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62749089
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.61462924
119Acute myeloid leukemia_Homo sapiens_hsa052210.61248959
120Axon guidance_Homo sapiens_hsa043600.61208910
121Fatty acid degradation_Homo sapiens_hsa000710.59496966
122Base excision repair_Homo sapiens_hsa034100.59441539
123Inositol phosphate metabolism_Homo sapiens_hsa005620.58932188
124VEGF signaling pathway_Homo sapiens_hsa043700.58869149
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57940783
126Ribosome_Homo sapiens_hsa030100.57709991
127Hepatitis B_Homo sapiens_hsa051610.57540630
128Colorectal cancer_Homo sapiens_hsa052100.55534964
129Carbon metabolism_Homo sapiens_hsa012000.54520810
130ErbB signaling pathway_Homo sapiens_hsa040120.54516872
131Prolactin signaling pathway_Homo sapiens_hsa049170.54338177
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53644472
133Lysine degradation_Homo sapiens_hsa003100.53496356
134Type II diabetes mellitus_Homo sapiens_hsa049300.53414218
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53330090
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52749425
137Estrogen signaling pathway_Homo sapiens_hsa049150.51540975
138Regulation of autophagy_Homo sapiens_hsa041400.50536360
139PPAR signaling pathway_Homo sapiens_hsa033200.48788181
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.47318951
141beta-Alanine metabolism_Homo sapiens_hsa004100.46826721
142Thyroid cancer_Homo sapiens_hsa052160.46062174
143MAPK signaling pathway_Homo sapiens_hsa040100.45250490
144Glucagon signaling pathway_Homo sapiens_hsa049220.44805720
145Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44727041
146Insulin signaling pathway_Homo sapiens_hsa049100.44692787
147Mismatch repair_Homo sapiens_hsa034300.43635753
148Glycerolipid metabolism_Homo sapiens_hsa005610.43608711
149Nicotine addiction_Homo sapiens_hsa050330.43364184
150RNA transport_Homo sapiens_hsa030130.41566035
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41339849
152TNF signaling pathway_Homo sapiens_hsa046680.40082879
153mRNA surveillance pathway_Homo sapiens_hsa030150.40062326
154TGF-beta signaling pathway_Homo sapiens_hsa043500.39497190
155FoxO signaling pathway_Homo sapiens_hsa040680.39209856
156Prostate cancer_Homo sapiens_hsa052150.38717389
157Chemical carcinogenesis_Homo sapiens_hsa052040.37123499
158Gap junction_Homo sapiens_hsa045400.36606980
159Glutathione metabolism_Homo sapiens_hsa004800.36524343
160Notch signaling pathway_Homo sapiens_hsa043300.36273879
161Oocyte meiosis_Homo sapiens_hsa041140.35846142
162Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35764046
163Renin-angiotensin system_Homo sapiens_hsa046140.34901670
164Glycosaminoglycan degradation_Homo sapiens_hsa005310.34515115
165Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34405742
166Pentose phosphate pathway_Homo sapiens_hsa000300.34248821
167Propanoate metabolism_Homo sapiens_hsa006400.33442773
168Choline metabolism in cancer_Homo sapiens_hsa052310.33256132
169Endometrial cancer_Homo sapiens_hsa052130.33063180
170Complement and coagulation cascades_Homo sapiens_hsa046100.32313110
171Type I diabetes mellitus_Homo sapiens_hsa049400.32267209

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