KIRREL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of multicellular organism growth (GO:0040015)6.05406689
2regulation of cilium movement (GO:0003352)6.01183336
3negative regulation of astrocyte differentiation (GO:0048712)5.57790217
4axoneme assembly (GO:0035082)5.54633713
5regulation of memory T cell differentiation (GO:0043380)5.49601196
6cytoplasmic mRNA processing body assembly (GO:0033962)5.21683972
7neuron fate determination (GO:0048664)5.16580585
8sex differentiation (GO:0007548)5.02431155
9adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.94647997
10histone H3-K4 trimethylation (GO:0080182)4.93776164
11regulation of chromatin binding (GO:0035561)4.80636716
12atrial cardiac muscle cell action potential (GO:0086014)4.77158176
13intraciliary transport (GO:0042073)4.76033805
14negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.73007973
15regulation of female gonad development (GO:2000194)4.56200946
16pyrimidine nucleobase catabolic process (GO:0006208)4.40418541
17protein polyglutamylation (GO:0018095)4.32818095
18kynurenine metabolic process (GO:0070189)4.25311018
19neuron cell-cell adhesion (GO:0007158)4.15443691
20regulation of beta-amyloid formation (GO:1902003)4.12081818
21cilium morphogenesis (GO:0060271)4.11479209
22dorsal/ventral axis specification (GO:0009950)4.08642440
23protein heterotetramerization (GO:0051290)4.05474867
24negative regulation of type 2 immune response (GO:0002829)3.93104906
25sterol catabolic process (GO:0016127)3.90186137
26cholesterol catabolic process (GO:0006707)3.90186137
27somite rostral/caudal axis specification (GO:0032525)3.88722722
28nucleobase catabolic process (GO:0046113)3.85835375
29stress granule assembly (GO:0034063)3.85633977
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.84723664
31mating behavior (GO:0007617)3.84704829
32chemosensory behavior (GO:0007635)3.80007105
33antibacterial humoral response (GO:0019731)3.76549346
34ovulation cycle (GO:0042698)3.75234672
35nucleoside diphosphate catabolic process (GO:0009134)3.75009434
36regulation of microtubule-based movement (GO:0060632)3.72229348
37negative regulation of cytosolic calcium ion concentration (GO:0051481)3.71587574
38type B pancreatic cell development (GO:0003323)3.71223875
39tryptophan catabolic process (GO:0006569)3.68151662
40indole-containing compound catabolic process (GO:0042436)3.68151662
41indolalkylamine catabolic process (GO:0046218)3.68151662
42microtubule bundle formation (GO:0001578)3.67380100
43detection of temperature stimulus (GO:0016048)3.66227635
44phosphorelay signal transduction system (GO:0000160)3.64869247
45regulation of cell maturation (GO:1903429)3.62654743
46water-soluble vitamin biosynthetic process (GO:0042364)3.61460572
47synaptic transmission, cholinergic (GO:0007271)3.61437409
48regulation of MHC class I biosynthetic process (GO:0045343)3.60017420
49axonal fasciculation (GO:0007413)3.57284839
50regulation of amyloid precursor protein catabolic process (GO:1902991)3.54100958
51auditory receptor cell differentiation (GO:0042491)3.52116677
52proline transport (GO:0015824)3.51229181
53regulation of establishment of cell polarity (GO:2000114)3.50941991
54regulation of sodium ion transmembrane transporter activity (GO:2000649)3.48923441
55calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.45154961
56antimicrobial humoral response (GO:0019730)3.43522219
57regulation of action potential (GO:0098900)3.41766288
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.41593862
59regulation of sodium ion transmembrane transport (GO:1902305)3.41150789
60dopamine receptor signaling pathway (GO:0007212)3.41005208
61glycogen catabolic process (GO:0005980)3.40509978
62axonemal dynein complex assembly (GO:0070286)3.40078084
63negative regulation of glial cell differentiation (GO:0045686)3.38396759
64cilium movement (GO:0003341)3.38032775
65ganglion development (GO:0061548)3.36129946
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.35150928
67olfactory bulb development (GO:0021772)3.34799851
68positive regulation of heat generation (GO:0031652)3.33998955
69detection of light stimulus involved in visual perception (GO:0050908)3.33776239
70detection of light stimulus involved in sensory perception (GO:0050962)3.33776239
71membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.33256619
72pre-miRNA processing (GO:0031054)3.29146056
73neuroblast proliferation (GO:0007405)3.29115171
74microtubule severing (GO:0051013)3.24250166
75regulation of interleukin-13 production (GO:0032656)3.22638291
76cell proliferation in forebrain (GO:0021846)3.20990856
77cellular response to electrical stimulus (GO:0071257)3.20721975
78ectoderm development (GO:0007398)3.20704585
79L-serine transport (GO:0015825)3.17918260
80dendrite development (GO:0016358)3.13090191
81glucan catabolic process (GO:0009251)3.12386291
82neuron projection extension involved in neuron projection guidance (GO:1902284)3.11409176
83axon extension involved in axon guidance (GO:0048846)3.11409176
84cellular potassium ion homeostasis (GO:0030007)3.11242887
85regulation of timing of cell differentiation (GO:0048505)3.10858280
86cellular copper ion homeostasis (GO:0006878)3.06782103
87response to gravity (GO:0009629)3.06355293
88regulation of heart rate by cardiac conduction (GO:0086091)3.06134320
89brain morphogenesis (GO:0048854)3.05791046
90detection of calcium ion (GO:0005513)3.05571197
91establishment of apical/basal cell polarity (GO:0035089)3.05063030
92regulation of astrocyte differentiation (GO:0048710)3.02861159
93cell fate commitment involved in formation of primary germ layer (GO:0060795)3.02696085
94forebrain neuron development (GO:0021884)3.01353008
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.99158185
96regulation of cholesterol biosynthetic process (GO:0045540)2.97575252
97cellular biogenic amine catabolic process (GO:0042402)2.97538493
98amine catabolic process (GO:0009310)2.97538493
99response to lipoprotein particle (GO:0055094)2.97350532
100potassium ion homeostasis (GO:0055075)2.97151233
101estrogen biosynthetic process (GO:0006703)2.96220892
102positive regulation of oligodendrocyte differentiation (GO:0048714)2.95745430
103alternative mRNA splicing, via spliceosome (GO:0000380)2.95400441
104tryptophan metabolic process (GO:0006568)2.94547079
105regulation of gene silencing by RNA (GO:0060966)2.94028891
106regulation of posttranscriptional gene silencing (GO:0060147)2.94028891
107regulation of gene silencing by miRNA (GO:0060964)2.94028891
108regulation of development, heterochronic (GO:0040034)2.91669287
109potassium ion transmembrane transport (GO:0071805)2.91359301
110cellular potassium ion transport (GO:0071804)2.91359301
111membrane repolarization during action potential (GO:0086011)2.90873865
112central nervous system neuron axonogenesis (GO:0021955)2.89938073
113establishment of monopolar cell polarity (GO:0061162)2.89606106
114establishment or maintenance of monopolar cell polarity (GO:0061339)2.89606106
115postsynaptic membrane organization (GO:0001941)2.89605236
116cellular polysaccharide catabolic process (GO:0044247)2.89571463
117striatum development (GO:0021756)2.87303970
118epithelial cell fate commitment (GO:0072148)2.86934284
119negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.86731714
120regulation of glycogen (starch) synthase activity (GO:2000465)2.86715685
121behavioral response to nicotine (GO:0035095)2.86416073
122retinal ganglion cell axon guidance (GO:0031290)2.86378832
123facial nerve structural organization (GO:0021612)2.86348642
124seminiferous tubule development (GO:0072520)2.85969361
125limb development (GO:0060173)2.83954527
126appendage development (GO:0048736)2.83954527
127protein localization to microtubule cytoskeleton (GO:0072698)2.83467034
128neurogenesis (GO:0022008)2.82004914
129regulation of heat generation (GO:0031650)2.81700261
130lipid particle organization (GO:0034389)2.81111021
131ADP metabolic process (GO:0046031)2.80624468
132cranial nerve structural organization (GO:0021604)2.79552750
133melanosome transport (GO:0032402)2.78468419
134signal complex assembly (GO:0007172)2.78435873
135positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.78353545
136innate immune response in mucosa (GO:0002227)2.78270662
137adipose tissue development (GO:0060612)2.77035069
138nonmotile primary cilium assembly (GO:0035058)2.76600013
139negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.75917480
140alanine transport (GO:0032328)2.74455995
141regulation of sodium ion transport (GO:0002028)2.72116294
142nodal signaling pathway (GO:0038092)2.70309842
143photoreceptor cell maintenance (GO:0045494)2.70288836
144polysaccharide catabolic process (GO:0000272)2.69954877
145neural tube formation (GO:0001841)2.69908339
146regulation of cellular amide metabolic process (GO:0034248)2.69853792
147acrosome assembly (GO:0001675)2.69841004
148cerebellar Purkinje cell differentiation (GO:0021702)2.69568844
149neuron recognition (GO:0008038)2.69512528
150positive regulation of triglyceride biosynthetic process (GO:0010867)2.69417831
151spinal cord motor neuron differentiation (GO:0021522)2.69307464
152regulation of establishment or maintenance of cell polarity (GO:0032878)2.68933166
153negative regulation of sodium ion transport (GO:0010766)2.68884339
154one-carbon compound transport (GO:0019755)2.68610536
155neuronal stem cell maintenance (GO:0097150)2.67902482
156substrate-independent telencephalic tangential migration (GO:0021826)2.67620218
157substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.67620218
158positive regulation of protein homooligomerization (GO:0032464)2.67510628
159establishment of melanosome localization (GO:0032401)2.66033049
160astrocyte differentiation (GO:0048708)2.64631387
161regulation of membrane repolarization (GO:0060306)2.64138141
162acrosome reaction (GO:0007340)2.64064439
163cell differentiation in spinal cord (GO:0021515)2.62913824
164dendritic spine morphogenesis (GO:0060997)2.62831463
165negative regulation of receptor-mediated endocytosis (GO:0048261)2.62363055
166regulation of hydrogen peroxide-induced cell death (GO:1903205)2.61898814
167serine transport (GO:0032329)2.61799437
168potassium ion transport (GO:0006813)2.61653822
169negative regulation of gliogenesis (GO:0014014)2.61564784
170pigment granule transport (GO:0051904)2.61519555
171regulation of acrosome reaction (GO:0060046)2.59199716
172central nervous system projection neuron axonogenesis (GO:0021952)2.59183964
173endocrine pancreas development (GO:0031018)2.58948219
174hippocampus development (GO:0021766)2.57921593
175neuron projection extension (GO:1990138)2.57514082
176adult walking behavior (GO:0007628)2.57405917
177neurotransmitter-gated ion channel clustering (GO:0072578)2.57342877
178glutamate secretion (GO:0014047)2.55258266
179negative regulation of mast cell activation (GO:0033004)2.54200809
180iron-sulfur cluster assembly (GO:0016226)2.54064153
181metallo-sulfur cluster assembly (GO:0031163)2.54064153
182inner ear receptor cell development (GO:0060119)2.49756333
183phosphatidylglycerol biosynthetic process (GO:0006655)2.49234482
184locomotory exploration behavior (GO:0035641)2.48300350
185regulation of translation, ncRNA-mediated (GO:0045974)2.47914419
186sensory perception of smell (GO:0007608)18.8473100
187protein insertion into membrane (GO:0051205)11.3135279
188sensory perception of chemical stimulus (GO:0007606)11.0578188
189protein localization to cilium (GO:0061512)10.6501991

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.94378434
2EZH2_22144423_ChIP-Seq_EOC_Human5.61631543
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.87852051
4DROSHA_22980978_ChIP-Seq_HELA_Human3.05293955
5ZNF263_19887448_ChIP-Seq_K562_Human2.58041948
6VDR_22108803_ChIP-Seq_LS180_Human2.56914761
7BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.56725889
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.27444508
9* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.21541073
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.20363328
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18295575
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18295575
13GBX2_23144817_ChIP-Seq_PC3_Human2.10980214
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06896095
15NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.03788006
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02135892
17IRF1_19129219_ChIP-ChIP_H3396_Human2.01174153
18RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.99870187
19SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.98691069
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97639812
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.95014577
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.95014577
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.95014577
24KDM2B_26808549_Chip-Seq_K562_Human1.93984689
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92813822
26REST_21632747_ChIP-Seq_MESCs_Mouse1.90303934
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89977584
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.89014745
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86226284
30CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83655091
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80930226
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.75887774
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70626128
34* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.69646279
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.69462649
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.69182144
37* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64942999
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61237103
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.61179668
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60426794
41ZNF274_21170338_ChIP-Seq_K562_Hela1.58695947
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56214750
43RING1B_27294783_Chip-Seq_NPCs_Mouse1.55836670
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.54167786
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51968098
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50989391
47ZFP281_27345836_Chip-Seq_ESCs_Mouse1.49856583
48SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.49497399
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49208313
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47957825
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47751587
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47423990
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46897860
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46868817
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45764970
56* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42796875
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42257831
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.40830408
59PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.39415250
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37557993
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.36932172
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36793695
63TBX3_20139965_ChIP-Seq_ESCs_Mouse1.36513195
64* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.36336005
65TBX3_20139965_ChIP-Seq_MESCs_Mouse1.36137697
66* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.35409872
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.32675071
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32432497
69RNF2_27304074_Chip-Seq_NSC_Mouse1.31931472
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.31858959
71SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31631837
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.31421813
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.31020895
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29809500
75CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29087355
76FUS_26573619_Chip-Seq_HEK293_Human1.29068685
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27471631
78IGF1R_20145208_ChIP-Seq_DFB_Human1.26025440
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24647936
80BCAT_22108803_ChIP-Seq_LS180_Human1.24185666
81* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.23328069
82* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.19899780
83TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18782780
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18616843
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17614809
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16941644
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16389651
88LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14378003
89LXR_22292898_ChIP-Seq_THP-1_Human1.13838524
90STAT1_20625510_ChIP-Seq_HELA_Human1.12779550
91POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11545970
92TAF15_26573619_Chip-Seq_HEK293_Human1.10177244
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09482152
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09419945
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09167006
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08772615
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07916573
98* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06945053
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05672428
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04582031
101WDR5_24793694_ChIP-Seq_LNCAP_Human1.04414383
102NANOG_21062744_ChIP-ChIP_HESCs_Human1.03235010
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02636236
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02512713
105* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02468287
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02421441
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01787195
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01127355
109AR_19668381_ChIP-Seq_PC3_Human1.00450043
110* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99760102
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99559474
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99559474
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99459490
114POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99450264
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98608707
116AHR_22903824_ChIP-Seq_MCF-7_Human0.98442160
117CBX2_27304074_Chip-Seq_ESCs_Mouse0.98151056
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98111259
119KLF5_25053715_ChIP-Seq_YYC3_Human0.97793426
120TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96833312
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96038258
122ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94917504
123SMAD4_21741376_ChIP-Seq_EPCs_Human0.94778408
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.94355076
125FLI1_27457419_Chip-Seq_LIVER_Mouse0.94317585
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94191112
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93215453
128KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93034325
129EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92797006
130CTCF_27219007_Chip-Seq_Bcells_Human0.91910210
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91718916
132ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91315777
133TAF2_19829295_ChIP-Seq_ESCs_Human0.91003181
134CTCF_20526341_ChIP-Seq_ESCs_Human0.90828176
135* ERA_21632823_ChIP-Seq_H3396_Human0.90763332
136SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90691009
137SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90687410
138SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90114343
139TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90102870
140SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.88225047
141* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.88152239
142SMAD3_21741376_ChIP-Seq_EPCs_Human0.88144867
143* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87622003
144MYC_18940864_ChIP-ChIP_HL60_Human0.85980438
145TP53_22573176_ChIP-Seq_HFKS_Human0.85774246
146CBP_20019798_ChIP-Seq_JUKART_Human0.85159757
147IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85159757
148SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84540748
149FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82015868
150FOXA1_25329375_ChIP-Seq_VCAP_Human0.82015868
151MYC_19829295_ChIP-Seq_ESCs_Human0.81115470
152TBL1_22424771_ChIP-Seq_293T_Human0.79424920
153SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77966250
154TP63_19390658_ChIP-ChIP_HaCaT_Human0.77945594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005394_taste/olfaction_phenotype4.69968228
2MP0005499_abnormal_olfactory_system4.69968228
3MP0008789_abnormal_olfactory_epithelium4.64119577
4MP0003122_maternal_imprinting4.06549827
5MP0002163_abnormal_gland_morphology3.17181335
6MP0003878_abnormal_ear_physiology2.61881397
7MP0005377_hearing/vestibular/ear_phenot2.61881397
8MP0001485_abnormal_pinna_reflex2.55918429
9MP0003806_abnormal_nucleotide_metabolis2.39383811
10MP0005645_abnormal_hypothalamus_physiol2.20463724
11MP0003121_genomic_imprinting2.18412280
12MP0010030_abnormal_orbit_morphology2.15572030
13MP0008877_abnormal_DNA_methylation2.08410576
14MP0003011_delayed_dark_adaptation2.02643932
15MP0002184_abnormal_innervation2.02578975
16MP0003252_abnormal_bile_duct2.00216976
17MP0001984_abnormal_olfaction12.4820007
18MP0006072_abnormal_retinal_apoptosis1.99031523
19MP0003880_abnormal_central_pattern1.88610653
20MP0001486_abnormal_startle_reflex1.80934784
21MP0002653_abnormal_ependyma_morphology1.79251900
22MP0000566_synostosis1.73632212
23MP0001968_abnormal_touch/_nociception1.69423089
24MP0003195_calcinosis1.68583996
25MP0002233_abnormal_nose_morphology1.68141194
26MP0003136_yellow_coat_color1.67543794
27MP0001986_abnormal_taste_sensitivity1.58823873
28MP0004133_heterotaxia1.54353718
29MP0000778_abnormal_nervous_system1.51287529
30MP0002736_abnormal_nociception_after1.47676498
31MP0002752_abnormal_somatic_nervous1.42030882
32MP0002557_abnormal_social/conspecific_i1.41719262
33MP0002837_dystrophic_cardiac_calcinosis1.37737496
34MP0003635_abnormal_synaptic_transmissio1.36856587
35MP0002160_abnormal_reproductive_system1.35098430
36MP0002734_abnormal_mechanical_nocicepti1.34254677
37MP0005253_abnormal_eye_physiology1.30912635
38MP0004859_abnormal_synaptic_plasticity1.25682627
39MP0002254_reproductive_system_inflammat1.25156551
40MP0005623_abnormal_meninges_morphology1.24379674
41MP0003890_abnormal_embryonic-extraembry1.20226842
42MP0000569_abnormal_digit_pigmentation1.20178939
43MP0002882_abnormal_neuron_morphology1.19872427
44MP0001293_anophthalmia1.19234841
45MP0002638_abnormal_pupillary_reflex1.18922167
46MP0001944_abnormal_pancreas_morphology1.16763379
47MP0003123_paternal_imprinting1.15561452
48MP0002909_abnormal_adrenal_gland1.15460376
49MP0002063_abnormal_learning/memory/cond1.15420914
50MP0003283_abnormal_digestive_organ1.14706833
51MP0004270_analgesia1.13382563
52MP0002152_abnormal_brain_morphology1.11265578
53MP0000049_abnormal_middle_ear1.10942329
54MP0003137_abnormal_impulse_conducting1.09459065
55MP0005367_renal/urinary_system_phenotyp1.08699589
56MP0000516_abnormal_urinary_system1.08699589
57MP0004885_abnormal_endolymph1.08241052
58MP0001529_abnormal_vocalization1.08035544
59MP0002572_abnormal_emotion/affect_behav1.07914436
60MP0002102_abnormal_ear_morphology1.06692951
61MP0003315_abnormal_perineum_morphology1.04063255
62MP0002928_abnormal_bile_duct1.01729490
63MP0001666_abnormal_nutrient_absorption1.01101255
64MP0001502_abnormal_circadian_rhythm0.99852007
65MP0004858_abnormal_nervous_system0.99023514
66MP0003861_abnormal_nervous_system0.97597587
67MP0009780_abnormal_chondrocyte_physiolo0.96661863
68MP0002249_abnormal_larynx_morphology0.96410915
69MP0003119_abnormal_digestive_system0.95734477
70MP0002697_abnormal_eye_size0.95460160
71MP0001346_abnormal_lacrimal_gland0.94116589
72MP0001324_abnormal_eye_pigmentation0.91575566
73MP0005646_abnormal_pituitary_gland0.91170021
74MP0005391_vision/eye_phenotype0.90806907
75MP0002272_abnormal_nervous_system0.89749491
76MP0005551_abnormal_eye_electrophysiolog0.89133871
77MP0005084_abnormal_gallbladder_morpholo0.88717458
78MP0005423_abnormal_somatic_nervous0.87330630
79MP0000026_abnormal_inner_ear0.86478889
80MP0009379_abnormal_foot_pigmentation0.85715523
81MP0003942_abnormal_urinary_system0.84995722
82MP0002210_abnormal_sex_determination0.83724623
83MP0001542_abnormal_bone_strength0.83456897
84MP0000383_abnormal_hair_follicle0.83090666
85MP0004142_abnormal_muscle_tone0.83089208
86MP0004742_abnormal_vestibular_system0.82874434
87MP0001963_abnormal_hearing_physiology0.82758930
88MP0003693_abnormal_embryo_hatching0.82502694
89MP0005171_absent_coat_pigmentation0.80603301
90MP0002234_abnormal_pharynx_morphology0.79296518
91MP0000653_abnormal_sex_gland0.78868227
92MP0002693_abnormal_pancreas_physiology0.78485339
93MP0002735_abnormal_chemical_nociception0.77385918
94MP0005389_reproductive_system_phenotype0.76799916
95MP0009745_abnormal_behavioral_response0.76005564
96MP0002127_abnormal_cardiovascular_syste0.75038863
97MP0003075_altered_response_to0.73971240
98MP0008875_abnormal_xenobiotic_pharmacok0.73057640
99MP0003329_amyloid_beta_deposits0.72379115
100MP0000955_abnormal_spinal_cord0.72249941
101MP0002064_seizures0.70493116
102MP0005248_abnormal_Harderian_gland0.69966990
103MP0002877_abnormal_melanocyte_morpholog0.68854085
104MP0002067_abnormal_sensory_capabilities0.68536227
105MP0003634_abnormal_glial_cell0.68516470
106MP0004811_abnormal_neuron_physiology0.68224277
107MP0003938_abnormal_ear_development0.67722514
108MP0001970_abnormal_pain_threshold0.66894662
109MP0000631_abnormal_neuroendocrine_gland0.65418672
110MP0005410_abnormal_fertilization0.65280489
111MP0002092_abnormal_eye_morphology0.64759800
112MP0005187_abnormal_penis_morphology0.64433716
113MP0003937_abnormal_limbs/digits/tail_de0.64041550
114MP0005379_endocrine/exocrine_gland_phen0.62079744
115MP0003633_abnormal_nervous_system0.61916040
116MP0006292_abnormal_olfactory_placode0.61554273
117MP0009046_muscle_twitch0.61526065
118MP0002733_abnormal_thermal_nociception0.61417235
119MP0000372_irregular_coat_pigmentation0.60678980
120MP0003941_abnormal_skin_development0.59157951
121MP0002938_white_spotting0.58503226
122MP0002229_neurodegeneration0.56386707
123MP0002282_abnormal_trachea_morphology0.54982349
124MP0002116_abnormal_craniofacial_bone0.54228603
125MP0002751_abnormal_autonomic_nervous0.53985304
126MP0000428_abnormal_craniofacial_morphol0.52334050
127MP0002822_catalepsy0.51321970
128MP0006276_abnormal_autonomic_nervous0.50601483
129MP0005195_abnormal_posterior_eye0.50270933
130MP0003879_abnormal_hair_cell0.50193954
131MP0001286_abnormal_eye_development0.49256005
132MP0002066_abnormal_motor_capabilities/c0.47720652
133MP0004924_abnormal_behavior0.45962908
134MP0005386_behavior/neurological_phenoty0.45962908
135MP0008874_decreased_physiological_sensi0.45541146
136MP0003787_abnormal_imprinting0.45186521
137MP0002009_preneoplasia0.45117074
138MP0003718_maternal_effect0.44963627

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)5.16610022
2Abnormal respiratory epithelium morphology (HP:0012253)5.00101969
3Abnormal respiratory motile cilium morphology (HP:0005938)5.00101969
4Abnormal ciliary motility (HP:0012262)4.96408716
5Progressive cerebellar ataxia (HP:0002073)4.88404571
6Abnormality of dentin (HP:0010299)4.53066889
7Abnormal respiratory motile cilium physiology (HP:0012261)4.49413510
8Action tremor (HP:0002345)4.24144690
9Dysmetric saccades (HP:0000641)4.21479755
10Back pain (HP:0003418)4.15657677
11Bifid tongue (HP:0010297)4.06645946
12Pendular nystagmus (HP:0012043)4.05273047
13Limb dystonia (HP:0002451)3.99198165
14Median cleft lip (HP:0000161)3.91191829
15Dysphonia (HP:0001618)3.86313224
16Abnormality of macular pigmentation (HP:0008002)3.80781209
17Rhinitis (HP:0012384)3.71645537
18Abnormality of the dental pulp (HP:0006479)3.57999021
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.57307237
20Retinal dysplasia (HP:0007973)3.45077564
21Abnormality of the dental root (HP:0006486)3.32722574
22Taurodontia (HP:0000679)3.32722574
23Abnormality of permanent molar morphology (HP:0011071)3.32722574
24Humeroradial synostosis (HP:0003041)3.29504249
25Synostosis involving the elbow (HP:0003938)3.29504249
26Pseudobulbar signs (HP:0002200)3.26638105
27Abnormality of sodium homeostasis (HP:0010931)3.17686078
28Pancreatic fibrosis (HP:0100732)3.14791396
29Abnormality of molar (HP:0011077)3.11289008
30Abnormality of molar morphology (HP:0011070)3.11289008
31Abnormality of midbrain morphology (HP:0002418)3.09789248
32Molar tooth sign on MRI (HP:0002419)3.09789248
33Prostate neoplasm (HP:0100787)3.01777745
34Gait imbalance (HP:0002141)2.97394814
35Short nail (HP:0001799)2.91297821
36Congenital primary aphakia (HP:0007707)2.90350686
37Urinary bladder sphincter dysfunction (HP:0002839)2.84632239
38Severe visual impairment (HP:0001141)2.83057312
39Absence seizures (HP:0002121)2.78339844
40Pancreatic cysts (HP:0001737)2.75951706
41Anosmia (HP:0000458)2.73471235
42Nephrogenic diabetes insipidus (HP:0009806)2.72987307
43Gaze-evoked nystagmus (HP:0000640)2.71792664
44Occipital encephalocele (HP:0002085)2.66299212
45Supernumerary spleens (HP:0009799)2.65553268
46Palpitations (HP:0001962)2.64675198
47Abdominal situs inversus (HP:0003363)2.64093892
48Abnormality of abdominal situs (HP:0011620)2.64093892
49Hyperglycinemia (HP:0002154)2.64022162
50Postaxial hand polydactyly (HP:0001162)2.63743031
51Chronic hepatic failure (HP:0100626)2.61965843
52Rib fusion (HP:0000902)2.57452822
53Complete atrioventricular canal defect (HP:0001674)2.55617440
54Medial flaring of the eyebrow (HP:0010747)2.55452810
55Nephronophthisis (HP:0000090)2.52722171
56Abnormality of the metopic suture (HP:0005556)2.51912590
57Postural tremor (HP:0002174)2.47429030
58Abnormality of the aortic arch (HP:0012303)2.47303924
59Atrioventricular canal defect (HP:0006695)2.46089564
60Amelogenesis imperfecta (HP:0000705)2.44721116
61Hypoplasia of the uterus (HP:0000013)2.44572820
62Sclerocornea (HP:0000647)2.43394457
63Decreased circulating renin level (HP:0003351)2.43381442
64Abnormal number of incisors (HP:0011064)2.41543134
65Aplasia involving bones of the upper limbs (HP:0009823)2.40789474
66Aplasia of the phalanges of the hand (HP:0009802)2.40789474
67Aplasia involving bones of the extremities (HP:0009825)2.40789474
68Hyperthyroidism (HP:0000836)2.39762235
69Facial cleft (HP:0002006)2.37876010
70Vaginal atresia (HP:0000148)2.37835990
71Tubulointerstitial nephritis (HP:0001970)2.37629728
72Polyphagia (HP:0002591)2.35413315
73Abnormality of the hepatic vasculature (HP:0006707)2.34133438
74Dysdiadochokinesis (HP:0002075)2.33744794
75Retinitis pigmentosa (HP:0000510)2.31742332
76Genital tract atresia (HP:0001827)2.30147111
77Focal seizures (HP:0007359)2.25803591
78Atrioventricular block (HP:0001678)2.23846947
79Oligodactyly (HP:0012165)2.22008700
80Dialeptic seizures (HP:0011146)2.20143617
81Choanal stenosis (HP:0000452)2.19088106
82Abnormality of the labia minora (HP:0012880)2.18994408
83Prominent metopic ridge (HP:0005487)2.18159747
84Labial hypoplasia (HP:0000066)2.17206686
85Impaired vibratory sensation (HP:0002495)2.16658449
86Atonic seizures (HP:0010819)2.15732155
87Anophthalmia (HP:0000528)2.14953253
88Megalencephaly (HP:0001355)2.12134881
89Chronic bronchitis (HP:0004469)2.11789161
90Aplasia/hypoplasia of the uterus (HP:0008684)2.11676815
91Impaired smooth pursuit (HP:0007772)2.10390066
92Cerebral inclusion bodies (HP:0100314)2.09800452
93Hyperglycinuria (HP:0003108)2.08952683
94Syncope (HP:0001279)2.08705353
95Abnormality of the axillary hair (HP:0100134)2.08687946
96Abnormality of secondary sexual hair (HP:0009888)2.08687946
97Onycholysis (HP:0001806)2.08666780
98Annular pancreas (HP:0001734)2.08277856
99Prolonged QT interval (HP:0001657)2.07951616
100Poor coordination (HP:0002370)2.07575589
101Cystic liver disease (HP:0006706)2.07314725
102True hermaphroditism (HP:0010459)2.06586859
103Hypoglycemic seizures (HP:0002173)2.06296475
104Torticollis (HP:0000473)2.05802654
105Abnormal pancreas size (HP:0012094)2.05601413
106Absent hair (HP:0002298)2.05499008
107Poor suck (HP:0002033)2.05431836
108Hemivertebrae (HP:0002937)2.04838332
109Abnormality of serine family amino acid metabolism (HP:0010894)2.04187410
110Abnormality of glycine metabolism (HP:0010895)2.04187410
111Intestinal atresia (HP:0011100)2.03310419
112Bony spicule pigmentary retinopathy (HP:0007737)2.02757851
113Vitreoretinal degeneration (HP:0000655)2.01889215
114Vertebral arch anomaly (HP:0008438)2.00828885
115Hypotelorism (HP:0000601)2.00697020
116Renal hypoplasia (HP:0000089)2.00500026
117Abnormal sex determination (HP:0012244)1.99973881
118Sex reversal (HP:0012245)1.99973881
119Tubular atrophy (HP:0000092)1.99896734
120Dynein arm defect of respiratory motile cilia (HP:0012255)1.99439807
121Absent/shortened dynein arms (HP:0200106)1.99439807
122Cutaneous syndactyly (HP:0012725)1.99062753
123Absent eyebrow (HP:0002223)1.98612912
124Cutaneous finger syndactyly (HP:0010554)1.98353018
125Hypochromic microcytic anemia (HP:0004840)1.97745830
126Insomnia (HP:0100785)1.97688806
127Febrile seizures (HP:0002373)1.96875661
128Bifid scrotum (HP:0000048)1.96377869
129Abnormal drinking behavior (HP:0030082)1.95923091
130Polydipsia (HP:0001959)1.95923091
131Bronchomalacia (HP:0002780)1.95504234
132High anterior hairline (HP:0009890)1.93744383
133Anencephaly (HP:0002323)1.93420748
134Postaxial foot polydactyly (HP:0001830)1.93332994
135Abnormality of the renal medulla (HP:0100957)1.92871300
136Holoprosencephaly (HP:0001360)1.92034142
137Oligodactyly (hands) (HP:0001180)1.90891408
138Bile duct proliferation (HP:0001408)1.90407635
139Abnormal biliary tract physiology (HP:0012439)1.90407635
140Ectopic kidney (HP:0000086)1.90360526
141Adrenal hypoplasia (HP:0000835)1.89487770
142Hypoplastic female external genitalia (HP:0012815)1.89056319
143Myokymia (HP:0002411)1.88581864
144Bronchiectasis (HP:0002110)1.87915624
145Hyperinsulinemic hypoglycemia (HP:0000825)1.87371441
146Postural instability (HP:0002172)1.86586276
147Male pseudohermaphroditism (HP:0000037)1.86415389
148Proximal tubulopathy (HP:0000114)1.86319234
149Abnormality of male internal genitalia (HP:0000022)1.86238268
150Hypoplastic labia majora (HP:0000059)1.85409804
151Septo-optic dysplasia (HP:0100842)1.85079038
152Volvulus (HP:0002580)1.84372364
153Severe Myopia (HP:0011003)1.84299694
154Scrotal hypoplasia (HP:0000046)1.84024660
155Micropenis (HP:0000054)1.83323733
156Colon cancer (HP:0003003)1.82868403
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.82711794
158Hypothermia (HP:0002045)1.82405391
159Neurofibrillary tangles (HP:0002185)1.81628755
160Vaginal fistula (HP:0004320)1.81392198
161Highly arched eyebrow (HP:0002553)1.80663511
162Hypoglycemic coma (HP:0001325)1.79550817
163Prominent occiput (HP:0000269)1.78689269
164Supernumerary bones of the axial skeleton (HP:0009144)1.77931736
165Morphological abnormality of the middle ear (HP:0008609)1.77911465
166Hemiparesis (HP:0001269)1.74802004
167Esotropia (HP:0000565)1.74307830
168Decreased testicular size (HP:0008734)1.74151835
169Failure to thrive in infancy (HP:0001531)1.74137207
170Oculomotor apraxia (HP:0000657)1.73775195
171Proximal placement of thumb (HP:0009623)1.72482436
172Narrow forehead (HP:0000341)1.71914287
173Slow saccadic eye movements (HP:0000514)1.71821196
174Short 4th metacarpal (HP:0010044)1.71105499
175Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.71105499
176Broad foot (HP:0001769)1.71037829
177Postnatal microcephaly (HP:0005484)1.70322591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG27.04299584
2PHKG17.04299584
3CDK196.02607764
4MAPK154.50790744
5TAF13.26446087
6FRK2.70290356
7OXSR12.51893209
8CDK122.32797877
9TRIB32.29922274
10MAP3K72.19431214
11SIK22.19311766
12EPHA41.97632956
13PAK31.91965137
14ICK1.89776630
15VRK21.89776171
16GRK11.89066124
17MAP3K21.83804734
18FGFR21.77925551
19EPHA21.74290141
20MUSK1.64864948
21DAPK21.63293030
22ERBB31.58843062
23PASK1.58397278
24ARAF1.56780470
25LMTK21.48326066
26WNK41.43266600
27PRKD31.42791292
28DYRK21.41020046
29NTRK21.39007568
30SRPK11.38441335
31EPHB21.35918451
32HIPK21.34552731
33GRK61.30868266
34NUAK11.30322469
35TYRO31.29006662
36PRKCG1.26723491
37MAPKAPK31.26625202
38CAMK2B1.24556722
39BMPR1B1.23552032
40CAMK2D1.20392712
41RIPK11.13362200
42PNCK1.13244360
43DAPK11.09210530
44STK381.06596968
45CAMK2G1.06437475
46ILK1.01873361
47GRK51.01243376
48PRKD20.99414040
49CSNK1A1L0.98135974
50LATS10.92996442
51MKNK10.92315534
52AURKA0.91403786
53TTK0.88535635
54DYRK1A0.88205610
55MST40.88085189
56BCR0.87455301
57FGR0.85186679
58VRK10.83360845
59DDR20.83269962
60YES10.82466152
61MINK10.82073904
62PRPF4B0.79916232
63ADRBK20.76600946
64CSNK1G10.75232817
65INSRR0.74581326
66STK240.72931491
67RPS6KA20.71285605
68CSNK1G20.70868414
69PRKCH0.70542512
70MAP3K40.67276246
71CDK11A0.67068257
72MAP4K20.65417982
73CDK150.65179446
74MAP3K60.63071712
75MATK0.62574092
76EPHA30.61980266
77PRKCI0.60914123
78CDK180.60292246
79CSNK1G30.60194793
80WNK30.59817414
81STK390.59374730
82DYRK1B0.58960130
83MAP3K30.58742845
84TIE10.58587690
85STK110.57457013
86CAMK2A0.56457794
87CAMK1D0.56413677
88MAP3K100.56147793
89MARK20.55035796
90CDK90.54951693
91AKT20.53951199
92DYRK30.53577298
93CSNK1A10.53501599
94CAMK1G0.53499346
95ALK0.53479149
96CAMKK20.53156212
97CDK50.52269153
98BRD40.51752778
99MAPK70.51569186
100ZAK0.51275214
101CAMKK10.50352653
102ACVR1B0.50188174
103CASK0.50099510
104CDK140.49453783
105BRSK10.48724474
106TNK20.48047252
107CSNK1E0.47628980
108STK38L0.47514472
109UHMK10.46208284
110MAPK130.45339718
111PRKCZ0.45188291
112SGK20.44986039
113SGK30.44534349
114MAPK100.43392224
115PRKAA10.42484025
116SGK4940.42204986
117SGK2230.42204986
118FER0.40954899
119STK30.39182667
120CHEK10.38906414
121PLK10.38602017
122AURKB0.37654355
123PINK10.37446572
124ATM0.37025248
125NTRK30.36611992
126PAK60.36444005
127SIK10.35933331
128BCKDK0.35797862
129PRKDC0.35583452
130PAK10.34976144
131PIM20.34790145
132MAP3K90.34273554
133NEK20.33927806
134TNIK0.33603253
135BRAF0.33560200
136PRKG10.33419845
137MARK10.33206728
138ADRBK10.32453876
139SMG10.31061131
140CSNK1D0.29999086
141BUB10.29607986
142EEF2K0.29370820
143AKT30.29324363
144RPS6KA60.29318664
145CHEK20.28908266
146MKNK20.28712567
147MAP2K70.28496646
148RPS6KA30.27857951
149NTRK10.27854075
150TGFBR10.27691871
151CDK10.27215035
152FGFR40.26068817
153PLK30.25855927
154STK160.25815962
155PRKCE0.25081289
156CAMK40.24818007
157PRKACA0.24579085
158BMX0.23345928
159FGFR10.23189398
160PRKCA0.23161155
161GSK3B0.23029742
162PRKD10.23018023

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.56526167
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.13060305
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.08772246
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.74990609
5Fatty acid biosynthesis_Homo sapiens_hsa000612.66696867
6Butanoate metabolism_Homo sapiens_hsa006502.27654400
7Taste transduction_Homo sapiens_hsa047422.23639196
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08555486
9Steroid biosynthesis_Homo sapiens_hsa001002.02811636
10Olfactory transduction_Homo sapiens_hsa0474010.5482391
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.98021682
12Morphine addiction_Homo sapiens_hsa050321.97198127
13Circadian entrainment_Homo sapiens_hsa047131.95249038
14Nitrogen metabolism_Homo sapiens_hsa009101.95019533
15Ribosome_Homo sapiens_hsa030101.85700288
16Phototransduction_Homo sapiens_hsa047441.85512094
17Sulfur relay system_Homo sapiens_hsa041221.81771471
18GABAergic synapse_Homo sapiens_hsa047271.74216166
19Oxidative phosphorylation_Homo sapiens_hsa001901.71729745
20Insulin secretion_Homo sapiens_hsa049111.69803475
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67698560
22Fat digestion and absorption_Homo sapiens_hsa049751.64488815
23Glutamatergic synapse_Homo sapiens_hsa047241.63429124
24Dopaminergic synapse_Homo sapiens_hsa047281.63334117
25Tryptophan metabolism_Homo sapiens_hsa003801.53526684
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48905067
27Ether lipid metabolism_Homo sapiens_hsa005651.48473106
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46837814
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46334986
30Salivary secretion_Homo sapiens_hsa049701.38467701
31Linoleic acid metabolism_Homo sapiens_hsa005911.36981254
32Gastric acid secretion_Homo sapiens_hsa049711.30328824
33Basal transcription factors_Homo sapiens_hsa030221.22697162
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22410736
35Caffeine metabolism_Homo sapiens_hsa002321.20513706
36Calcium signaling pathway_Homo sapiens_hsa040201.20465138
37Notch signaling pathway_Homo sapiens_hsa043301.19716517
38Sulfur metabolism_Homo sapiens_hsa009201.18952796
39Cholinergic synapse_Homo sapiens_hsa047251.17659402
40Thyroid hormone synthesis_Homo sapiens_hsa049181.15795001
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14927069
42Amphetamine addiction_Homo sapiens_hsa050311.14250831
43cAMP signaling pathway_Homo sapiens_hsa040241.13822713
44Propanoate metabolism_Homo sapiens_hsa006401.13766866
45Alcoholism_Homo sapiens_hsa050341.12401980
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12099925
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10981892
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.09571319
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09316928
50Folate biosynthesis_Homo sapiens_hsa007901.08504987
51beta-Alanine metabolism_Homo sapiens_hsa004101.07837513
52Fatty acid metabolism_Homo sapiens_hsa012121.07317626
53Pancreatic secretion_Homo sapiens_hsa049721.04358363
54Histidine metabolism_Homo sapiens_hsa003401.03573939
55Vitamin B6 metabolism_Homo sapiens_hsa007501.01440268
56Protein export_Homo sapiens_hsa030601.00836181
57Nicotine addiction_Homo sapiens_hsa050330.97714894
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96161098
59Long-term potentiation_Homo sapiens_hsa047200.95558485
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92774237
61Synaptic vesicle cycle_Homo sapiens_hsa047210.92687717
62Protein digestion and absorption_Homo sapiens_hsa049740.92007332
63Melanogenesis_Homo sapiens_hsa049160.89698268
64Type II diabetes mellitus_Homo sapiens_hsa049300.86624905
65Axon guidance_Homo sapiens_hsa043600.86511459
66Glucagon signaling pathway_Homo sapiens_hsa049220.86347923
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85370943
68Serotonergic synapse_Homo sapiens_hsa047260.83985514
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83804058
70One carbon pool by folate_Homo sapiens_hsa006700.81942898
71Huntingtons disease_Homo sapiens_hsa050160.81146484
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80159460
73Renin secretion_Homo sapiens_hsa049240.78940201
74GnRH signaling pathway_Homo sapiens_hsa049120.78644729
75Retinol metabolism_Homo sapiens_hsa008300.77671752
76Estrogen signaling pathway_Homo sapiens_hsa049150.76688514
77Bile secretion_Homo sapiens_hsa049760.75933564
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75254743
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74591554
80Arginine and proline metabolism_Homo sapiens_hsa003300.74037706
81Cocaine addiction_Homo sapiens_hsa050300.71805229
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70733160
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69340556
84Ovarian steroidogenesis_Homo sapiens_hsa049130.66177526
85Peroxisome_Homo sapiens_hsa041460.65647887
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64002611
87Arachidonic acid metabolism_Homo sapiens_hsa005900.63439669
88RNA polymerase_Homo sapiens_hsa030200.63185893
89Vibrio cholerae infection_Homo sapiens_hsa051100.61602075
90Basal cell carcinoma_Homo sapiens_hsa052170.60037863
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56292968
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.56022984
93Metabolic pathways_Homo sapiens_hsa011000.55765464
94Starch and sucrose metabolism_Homo sapiens_hsa005000.53674303
95Collecting duct acid secretion_Homo sapiens_hsa049660.53139439
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52463963
97ABC transporters_Homo sapiens_hsa020100.52107152
98Sphingolipid metabolism_Homo sapiens_hsa006000.51541119
99N-Glycan biosynthesis_Homo sapiens_hsa005100.50925511
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50324457
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50188084
102Tight junction_Homo sapiens_hsa045300.49780810
103Gap junction_Homo sapiens_hsa045400.49399620
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47859298
105Glutathione metabolism_Homo sapiens_hsa004800.47715826
106Hippo signaling pathway_Homo sapiens_hsa043900.47188436
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46673446
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.46391216
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45862178
110Rap1 signaling pathway_Homo sapiens_hsa040150.44215623
111Fanconi anemia pathway_Homo sapiens_hsa034600.44152754
112Cardiac muscle contraction_Homo sapiens_hsa042600.43848202
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43191882
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.42581855
115Homologous recombination_Homo sapiens_hsa034400.41471577
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40741192
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40412230
118Long-term depression_Homo sapiens_hsa047300.40403624
119Oocyte meiosis_Homo sapiens_hsa041140.39475745
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39404933
121Oxytocin signaling pathway_Homo sapiens_hsa049210.38647657
122Parkinsons disease_Homo sapiens_hsa050120.37659938
123Purine metabolism_Homo sapiens_hsa002300.35368191
124Ras signaling pathway_Homo sapiens_hsa040140.35112966
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34758730
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34342087
127Non-homologous end-joining_Homo sapiens_hsa034500.33712195
128Mineral absorption_Homo sapiens_hsa049780.32592872
129Wnt signaling pathway_Homo sapiens_hsa043100.30812252
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30130074
131Fructose and mannose metabolism_Homo sapiens_hsa000510.29446529
132Fatty acid degradation_Homo sapiens_hsa000710.29392708
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29327809
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.29111825
135Alzheimers disease_Homo sapiens_hsa050100.27889012
136Chemical carcinogenesis_Homo sapiens_hsa052040.27832318
137Insulin signaling pathway_Homo sapiens_hsa049100.26713249
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.26154526
139Pyruvate metabolism_Homo sapiens_hsa006200.26104034
140Prion diseases_Homo sapiens_hsa050200.25591689
141Biosynthesis of amino acids_Homo sapiens_hsa012300.23655638
142Glycerolipid metabolism_Homo sapiens_hsa005610.20749111
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18694969
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18601297
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.18320096
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18050008
147Hedgehog signaling pathway_Homo sapiens_hsa043400.17654719
148Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17306543
149Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17186729

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