KIR3DS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)8.00868237
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)8.00868237
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.68323363
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.40227601
5cellular response to interleukin-15 (GO:0071350)6.35807487
6response to interleukin-15 (GO:0070672)6.07757797
7antigen processing and presentation of endogenous antigen (GO:0019883)6.01640160
8positive regulation of gamma-delta T cell activation (GO:0046645)6.00814615
9neutrophil activation involved in immune response (GO:0002283)6.00785318
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.60984836
11leukocyte aggregation (GO:0070486)5.60792957
12regulation of B cell receptor signaling pathway (GO:0050855)5.50631114
13activated T cell proliferation (GO:0050798)5.33774186
14negative thymic T cell selection (GO:0045060)4.81894186
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.80752771
16negative T cell selection (GO:0043383)4.77954954
17leukocyte migration involved in inflammatory response (GO:0002523)4.74881302
18regulation of natural killer cell mediated immunity (GO:0002715)4.68625891
19regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.68625891
20T cell migration (GO:0072678)4.67636620
21positive thymic T cell selection (GO:0045059)4.64988765
22negative regulation of lymphocyte mediated immunity (GO:0002707)4.58438267
23neutrophil activation (GO:0042119)4.44721506
24regulation of gamma-delta T cell activation (GO:0046643)4.35934813
25detection of bacterium (GO:0016045)4.25798016
26regulation of gamma-delta T cell differentiation (GO:0045586)4.25507432
27granulocyte activation (GO:0036230)4.20804911
28detection of other organism (GO:0098543)4.20697426
29positive T cell selection (GO:0043368)4.08644231
30negative regulation of leukocyte mediated immunity (GO:0002704)4.06607176
31cellular extravasation (GO:0045123)4.01764240
32thymic T cell selection (GO:0045061)3.93222660
33interferon-gamma production (GO:0032609)3.91748086
34positive regulation of mast cell activation (GO:0033005)3.88630409
35regulation of B cell differentiation (GO:0045577)3.85795983
36regulation of alpha-beta T cell proliferation (GO:0046640)3.83541690
37antigen processing and presentation via MHC class Ib (GO:0002475)3.81096959
38regulation of T cell tolerance induction (GO:0002664)3.80655716
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.78295546
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.78295546
41modulation by symbiont of host immune response (GO:0052553)3.78295546
42positive regulation by symbiont of host defense response (GO:0052509)3.78295546
43modulation by symbiont of host defense response (GO:0052031)3.78295546
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.78295546
45positive regulation of T cell mediated cytotoxicity (GO:0001916)3.76916714
46T cell selection (GO:0045058)3.76238446
47negative regulation of interleukin-12 production (GO:0032695)3.73171954
48positive regulation of natural killer cell mediated immunity (GO:0002717)3.68938679
49macrophage activation involved in immune response (GO:0002281)3.68274101
50leukocyte degranulation (GO:0043299)3.68010540
51regulation of T cell mediated cytotoxicity (GO:0001914)3.66477611
52regulation of mast cell degranulation (GO:0043304)3.64752250
53negative regulation of T cell mediated immunity (GO:0002710)3.63817158
54negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.61916942
55regulation of leukocyte mediated cytotoxicity (GO:0001910)3.61824565
56myeloid cell activation involved in immune response (GO:0002275)3.61632407
57positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.60065711
58B cell receptor signaling pathway (GO:0050853)3.56435922
59negative regulation of phagocytosis (GO:0050765)3.55822634
60immunoglobulin mediated immune response (GO:0016064)3.43428162
61regulation of tolerance induction (GO:0002643)3.40627764
62positive regulation of granulocyte differentiation (GO:0030854)3.39248253
63positive regulation of B cell differentiation (GO:0045579)3.36728639
64regulation of mast cell activation involved in immune response (GO:0033006)3.36491597
65cellular defense response (GO:0006968)3.35620223
66positive regulation of alpha-beta T cell proliferation (GO:0046641)3.34112881
67megakaryocyte development (GO:0035855)3.33849471
68regulation of regulatory T cell differentiation (GO:0045589)3.30823590
69regulation of mast cell activation (GO:0033003)3.28289180
70regulation of cell killing (GO:0031341)3.27195949
71positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.23851623
72respiratory burst (GO:0045730)3.23627637
73positive regulation of cell killing (GO:0031343)3.22622167
74microglial cell activation (GO:0001774)3.16066088
75detection of external biotic stimulus (GO:0098581)3.12644732
76positive regulation of isotype switching (GO:0045830)3.12587184
77regulation of myeloid leukocyte mediated immunity (GO:0002886)3.11680050
78positive regulation of mast cell activation involved in immune response (GO:0033008)3.11627088
79positive regulation of mast cell degranulation (GO:0043306)3.11627088
80lymphocyte migration (GO:0072676)3.11443929
81positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.11028455
82antigen receptor-mediated signaling pathway (GO:0050851)3.10221364
83negative regulation of innate immune response (GO:0045824)3.08350003
84negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.08289294
85negative regulation of T-helper cell differentiation (GO:0045623)3.08289294
86regulation of leukocyte degranulation (GO:0043300)3.03959032
87cytidine metabolic process (GO:0046087)3.03122177
88cytidine catabolic process (GO:0006216)3.03122177
89cytidine deamination (GO:0009972)3.03122177
90T cell receptor signaling pathway (GO:0050852)3.01243854
91regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.98938115
92mast cell activation (GO:0045576)2.98220554
93negative regulation of alpha-beta T cell activation (GO:0046636)2.96315149
94regulation of platelet aggregation (GO:0090330)2.96077675
95Arp2/3 complex-mediated actin nucleation (GO:0034314)2.91777523
96cellular response to type I interferon (GO:0071357)2.91473618
97type I interferon signaling pathway (GO:0060337)2.91473618
98response to type I interferon (GO:0034340)2.90300143
99B cell mediated immunity (GO:0019724)2.88208389
100leukocyte cell-cell adhesion (GO:0007159)2.86103084

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.73217568
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.58090274
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.55526679
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.95179867
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.91422724
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.60307105
7RUNX_20019798_ChIP-Seq_JUKART_Human3.32698384
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.12050918
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.90306125
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.86438076
11MYB_26560356_Chip-Seq_TH2_Human2.81715784
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.77969740
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77607716
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.71874811
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.65361055
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.61574893
17UTX_26944678_Chip-Seq_JUKART_Human2.58943008
18SCL_19346495_ChIP-Seq_HPC-7_Human2.55781067
19SPI1_23547873_ChIP-Seq_NB4_Human2.55348340
20MAF_26560356_Chip-Seq_TH1_Human2.53325116
21SPI1_23127762_ChIP-Seq_K562_Human2.51321720
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50861024
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.49030529
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46593774
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.45601726
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.32956353
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32902321
28MYB_26560356_Chip-Seq_TH1_Human2.28308719
29MYC_22102868_ChIP-Seq_BL_Human2.25412562
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.21885648
31VDR_24763502_ChIP-Seq_THP-1_Human2.18196054
32VDR_21846776_ChIP-Seq_THP-1_Human2.18089888
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.17974699
34BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07534240
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07139121
36GATA3_27048872_Chip-Seq_THYMUS_Human2.04388144
37MAF_26560356_Chip-Seq_TH2_Human2.03663208
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.99645467
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89380890
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79750291
41TCF7_22412390_ChIP-Seq_EML_Mouse1.79616178
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78827624
43GATA1_19941827_ChIP-Seq_MEL_Mouse1.72801103
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66732768
45SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.66135078
46KDM2B_26808549_Chip-Seq_DND41_Human1.63468544
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62297810
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61084201
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56470152
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.56290322
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55411147
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54528018
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52604304
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.50860644
55GATA3_26560356_Chip-Seq_TH2_Human1.48728696
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46019155
57GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39246382
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37871694
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36865193
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36634040
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36257781
62GATA1_19941826_ChIP-Seq_K562_Human1.31415957
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31056847
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.28006271
65RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.23258047
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23131947
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23020246
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22889142
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21884685
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.21847466
71PU_27001747_Chip-Seq_BMDM_Mouse1.21080157
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20793503
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20700776
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19813091
75GATA1_22025678_ChIP-Seq_K562_Human1.18114359
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17043597
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16293627
78VDR_24787735_ChIP-Seq_THP-1_Human1.15455329
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14436338
80GATA2_19941826_ChIP-Seq_K562_Human1.10376147
81BCL6_27268052_Chip-Seq_Bcells_Human1.07974067
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06518928
83LXR_22292898_ChIP-Seq_THP-1_Human1.06455333
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04528080
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04062275
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01384987
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.00787019
88RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00584705
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00306836
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00074818
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98218199
92BCOR_27268052_Chip-Seq_Bcells_Human0.96532257
93NCOR1_26117541_ChIP-Seq_K562_Human0.92076329
94CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92060504
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91884819
96CIITA_25753668_ChIP-Seq_RAJI_Human0.90400385
97SPI1_20517297_ChIP-Seq_HL60_Human0.89079144
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88961498
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.86395781
100SA1_27219007_Chip-Seq_ERYTHROID_Human0.83719093

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.64206902
2MP0003724_increased_susceptibility_to4.59347538
3MP0003436_decreased_susceptibility_to4.20742811
4MP0001835_abnormal_antigen_presentation3.98600093
5MP0006082_CNS_inflammation3.73054111
6MP0005464_abnormal_platelet_physiology3.69401781
7MP0003763_abnormal_thymus_physiology3.58611763
8MP0001800_abnormal_humoral_immune3.19503623
9MP0005000_abnormal_immune_tolerance3.03141074
10MP0005025_abnormal_response_to2.83508283
11MP0002723_abnormal_immune_serum2.77996367
12MP0003303_peritoneal_inflammation2.74827597
13MP0002420_abnormal_adaptive_immunity2.74008010
14MP0001790_abnormal_immune_system2.71631320
15MP0005387_immune_system_phenotype2.71631320
16MP0001819_abnormal_immune_cell2.70976189
17MP0002419_abnormal_innate_immunity2.69024352
18MP0002452_abnormal_antigen_presenting2.56956415
19MP0000685_abnormal_immune_system2.51469300
20MP0009785_altered_susceptibility_to2.49482014
21MP0009333_abnormal_splenocyte_physiolog2.40923577
22MP0002405_respiratory_system_inflammati2.37159621
23MP0002398_abnormal_bone_marrow2.36659117
24MP0002132_abnormal_respiratory_system2.31138783
25MP0000716_abnormal_immune_system2.10828279
26MP0010155_abnormal_intestine_physiology2.10510626
27MP0003300_gastrointestinal_ulcer2.07320779
28MP0002148_abnormal_hypersensitivity_rea2.03481138
29MP0003866_abnormal_defecation1.98267663
30MP0001533_abnormal_skeleton_physiology1.96678783
31MP0000703_abnormal_thymus_morphology1.96563266
32MP0002722_abnormal_immune_system1.88185803
33MP0000689_abnormal_spleen_morphology1.87140094
34MP0001845_abnormal_inflammatory_respons1.74738104
35MP0002429_abnormal_blood_cell1.72656908
36MP0001851_eye_inflammation1.64865391
37MP0001873_stomach_inflammation1.64262463
38MP0004947_skin_inflammation1.57940559
39MP0003183_abnormal_peptide_metabolism1.57291049
40MP0003690_abnormal_glial_cell1.56542951
41MP0008260_abnormal_autophagy1.49634563
42MP0003172_abnormal_lysosome_physiology1.44903679
43MP0000858_altered_metastatic_potential1.44004808
44MP0004381_abnormal_hair_follicle1.42502683
45MP0000465_gastrointestinal_hemorrhage1.42489607
46MP0004510_myositis1.35281039
47MP0003828_pulmonary_edema1.34035685
48MP0008469_abnormal_protein_level1.29326569
49MP0002396_abnormal_hematopoietic_system1.22518691
50MP0005310_abnormal_salivary_gland1.13536193
51MP0003191_abnormal_cellular_cholesterol1.12547848
52MP0005058_abnormal_lysosome_morphology1.11039559
53MP0002998_abnormal_bone_remodeling1.07803280
54MP0004883_abnormal_blood_vessel1.06611799
55MP0002933_joint_inflammation1.06592032
56MP0008004_abnormal_stomach_pH1.03357928
57MP0005451_abnormal_body_composition1.00915811
58MP0001663_abnormal_digestive_system0.99865842
59MP0002166_altered_tumor_susceptibility0.99716494
60MP0004130_abnormal_muscle_cell0.99556812
61MP0003448_altered_tumor_morphology0.99455464
62MP0000490_abnormal_crypts_of0.99174406
63MP0005397_hematopoietic_system_phenotyp0.99162097
64MP0001545_abnormal_hematopoietic_system0.99162097
65MP0009764_decreased_sensitivity_to0.98757829
66MP0009763_increased_sensitivity_to0.98313840
67MP0000015_abnormal_ear_pigmentation0.94025072
68MP0001986_abnormal_taste_sensitivity0.86836238
69MP0005075_abnormal_melanosome_morpholog0.86431026
70MP0002277_abnormal_respiratory_mucosa0.84639026
71MP0000569_abnormal_digit_pigmentation0.83106983
72MP0000343_altered_response_to0.81172387
73MP0005166_decreased_susceptibility_to0.76730388
74MP0005390_skeleton_phenotype0.72599905
75MP0005164_abnormal_response_to0.72102913
76MP0009278_abnormal_bone_marrow0.71047000
77MP0003075_altered_response_to0.70991045
78MP0009765_abnormal_xenobiotic_induced0.69130239
79MP0004808_abnormal_hematopoietic_stem0.67822368
80MP0005083_abnormal_biliary_tract0.66772570
81MP0002019_abnormal_tumor_incidence0.65643729
82MP0000249_abnormal_blood_vessel0.62968336
83MP0008874_decreased_physiological_sensi0.60589377
84MP0003045_fibrosis0.59423920
85MP0003566_abnormal_cell_adhesion0.59012634
86MP0003795_abnormal_bone_structure0.58982327
87MP0002693_abnormal_pancreas_physiology0.56684142
88MP0003638_abnormal_response/metabolism_0.55845078
89MP0005381_digestive/alimentary_phenotyp0.54907106
90MP0005174_abnormal_tail_pigmentation0.54641924
91MP0001853_heart_inflammation0.54461674
92MP0002006_tumorigenesis0.50698650
93MP0008873_increased_physiological_sensi0.48356552
94MP0001765_abnormal_ion_homeostasis0.46673640
95MP0004142_abnormal_muscle_tone0.46560183
96MP0009642_abnormal_blood_homeostasis0.45689477
97MP0005084_abnormal_gallbladder_morpholo0.45266462
98MP0002332_abnormal_exercise_endurance0.44402687
99MP0000920_abnormal_myelination0.42721419
100MP0006054_spinal_hemorrhage0.40937370

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.91553032
2Abnormality of macrophages (HP:0004311)5.45443833
3Prolonged bleeding time (HP:0003010)5.40188138
4T lymphocytopenia (HP:0005403)5.33905906
5Recurrent abscess formation (HP:0002722)5.33690888
6Myositis (HP:0100614)5.20457727
7Recurrent bacterial skin infections (HP:0005406)5.07475822
8Abnormality of T cell number (HP:0011839)4.92079516
9Stomatitis (HP:0010280)4.82701009
10Orchitis (HP:0100796)4.56364621
11Optic neuritis (HP:0100653)4.44542373
12Retrobulbar optic neuritis (HP:0100654)4.44542373
13Encephalitis (HP:0002383)4.38657353
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.14531998
15Recurrent fungal infections (HP:0002841)4.11762355
16Spontaneous hematomas (HP:0007420)4.11305864
17Epistaxis (HP:0000421)4.07721835
18Pustule (HP:0200039)4.06076238
19Panhypogammaglobulinemia (HP:0003139)4.06000405
20Meningitis (HP:0001287)4.04791139
21Elevated erythrocyte sedimentation rate (HP:0003565)4.00086574
22Chronic obstructive pulmonary disease (HP:0006510)3.98168444
23Obstructive lung disease (HP:0006536)3.98168444
24Petechiae (HP:0000967)3.95489498
25Gastrointestinal infarctions (HP:0005244)3.87303439
26Abnormality of T cells (HP:0002843)3.75410047
27Gingival bleeding (HP:0000225)3.71109596
28Joint swelling (HP:0001386)3.70098023
29Recurrent gram-negative bacterial infections (HP:0005420)3.66747774
30Purpura (HP:0000979)3.60633364
31Increased IgM level (HP:0003496)3.50267732
32Abnormal platelet volume (HP:0011876)3.46125102
33Mediastinal lymphadenopathy (HP:0100721)3.34745713
34Menorrhagia (HP:0000132)3.30223434
35Chest pain (HP:0100749)3.27282605
36Recurrent skin infections (HP:0001581)3.25357825
37Keratoconjunctivitis sicca (HP:0001097)3.17832151
38Granulocytopenia (HP:0001913)3.14563840
39Recurrent viral infections (HP:0004429)3.14218423
40Vasculitis (HP:0002633)3.09690920
41Leukocytosis (HP:0001974)3.05502006
42Increased IgE level (HP:0003212)2.95050887
43Keratoconjunctivitis (HP:0001096)2.92574797
44Gingivitis (HP:0000230)2.92237151
45Eosinophilia (HP:0001880)2.91414369
46Recurrent cutaneous fungal infections (HP:0011370)2.87390881
47Chronic mucocutaneous candidiasis (HP:0002728)2.87390881
48Severe combined immunodeficiency (HP:0004430)2.86241384
49Pulmonary infiltrates (HP:0002113)2.81314559
50Increased mean platelet volume (HP:0011877)2.81087081
51Inflammation of the large intestine (HP:0002037)2.80062337
52Arterial thrombosis (HP:0004420)2.73157581
53Gastrointestinal inflammation (HP:0004386)2.70044714
54Lymphopenia (HP:0001888)2.66817377
55Episodic fever (HP:0001954)2.66130945
56Anorexia (HP:0002039)2.65308331
57Pulmonary embolism (HP:0002204)2.62551704
58Urticaria (HP:0001025)2.60031996
59Increased serum ferritin (HP:0003281)2.56605394
60Hemiplegia (HP:0002301)2.55091205
61Nasal polyposis (HP:0100582)2.51159189
62Abnormality of T cell physiology (HP:0011840)2.50561806
63IgM deficiency (HP:0002850)2.50420959
64Hemoptysis (HP:0002105)2.50345691
65Abnormality of the common coagulation pathway (HP:0010990)2.50271363
66Hypoproteinemia (HP:0003075)2.49243642
67Impaired platelet aggregation (HP:0003540)2.49003118
68Abnormal platelet function (HP:0011869)2.49003118
69Acute hepatic failure (HP:0006554)2.48787496
70Abnormality of eosinophils (HP:0001879)2.47789508
71Abnormality of cells of the lymphoid lineage (HP:0012140)2.47744782
72Autoimmune hemolytic anemia (HP:0001890)2.36943046
73Combined immunodeficiency (HP:0005387)2.32408571
74Abnormality of iron homeostasis (HP:0011031)2.32266825
75Hepatosplenomegaly (HP:0001433)2.27012434
76Hyperlipoproteinemia (HP:0010980)2.25540005
77Hypergammaglobulinemia (HP:0010702)2.24719428
78Cellulitis (HP:0100658)2.21644763
79Gangrene (HP:0100758)2.18464195
80Hypochromic anemia (HP:0001931)2.17229370
81Recurrent bronchitis (HP:0002837)2.15656067
82Papilledema (HP:0001085)2.14942552
83Chronic diarrhea (HP:0002028)2.05447584
84Abnormality of the pleura (HP:0002103)2.04274132
85Colitis (HP:0002583)2.03277529
86Increased CSF protein (HP:0002922)2.02611059
87Agammaglobulinemia (HP:0004432)2.02471811
88IgG deficiency (HP:0004315)2.01493875
89Abnormality of the nasal mucosa (HP:0000433)2.00765468
90Sepsis (HP:0100806)2.00061372
91Glomerulopathy (HP:0100820)1.99730205
92Arthralgia (HP:0002829)1.98718229
93Autoimmune thrombocytopenia (HP:0001973)1.97640187
94Abnormality of transition element cation homeostasis (HP:0011030)1.96276099
95Verrucae (HP:0200043)1.90540262
96Papilloma (HP:0012740)1.90540262
97Acne (HP:0001061)1.90404341
98Amaurosis fugax (HP:0100576)1.88427672
99Vertigo (HP:0002321)1.87698960
100Viral hepatitis (HP:0006562)1.87488472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.64901697
2TXK4.16764194
3RIPK44.10245507
4FES3.06975689
5ZAP702.97595130
6CSK2.89483406
7BLK2.66597257
8BTK2.54548863
9PRPF4B2.51208183
10TAOK32.36966492
11GRK62.27693249
12TNK22.27066983
13TYK22.21176045
14EPHB12.19505071
15SYK2.08571961
16MAP2K32.08504141
17JAK12.01898432
18ERN12.00288921
19ITK1.91247452
20JAK31.87312065
21IRAK41.87012413
22FGR1.75067085
23HCK1.71616650
24LCK1.67914142
25LYN1.50703370
26MAP3K131.50517104
27TEC1.50452119
28SIK31.47969093
29STK101.38398481
30CSF1R1.33975199
31TAOK11.33658163
32TESK21.30537032
33MAP3K31.25445135
34MARK31.24639488
35MAP3K111.21955395
36JAK21.10205599
37PDK11.09415299
38IKBKE1.06613255
39PTK2B1.02189907
40PRKCQ1.00925327
41MAP3K140.94994611
42BMPR20.94827182
43KIT0.92570311
44IKBKB0.90605514
45MAP3K10.90527311
46KSR20.90108379
47TBK10.87414406
48FYN0.82589536
49KDR0.81314084
50MARK20.79815745
51BMX0.78992612
52MAPK120.78415994
53TRIB30.76206806
54SIK20.74257814
55PTK60.73264149
56PIK3CG0.72616655
57TGFBR20.69539983
58PIM10.66170422
59YES10.62093020
60PRKCH0.61764333
61PDPK10.61708583
62CDK40.61376656
63LRRK20.57957968
64PRKD20.57154169
65RET0.56700142
66FGFR40.56412570
67HIPK20.56079984
68MAP3K70.52499195
69GRK70.52370332
70FGFR30.51105054
71MAP2K60.51090044
72MAP3K100.50927759
73CDC42BPA0.46125719
74STK380.45765110
75STK110.45568208
76IRAK10.45104880
77MAP3K50.45015007
78MST40.44902884
79GRK50.44778318
80CDK190.44295606
81TAOK20.44251731
82DYRK1B0.38841689
83CAMKK10.38382993
84MELK0.35873556
85INSR0.35104706
86PRKD10.34926263
87MATK0.34646328
88NLK0.33494141
89MAPK70.33320301
90RAF10.33316298
91MAP3K20.33275735
92SGK30.32639700
93CAMKK20.32460039
94MAPKAPK20.30312555
95EPHA30.30233590
96PAK10.29742936
97MAPK110.29574481
98SMG10.25806573
99ABL10.24669696
100MOS0.23723432

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.00536026
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.79548357
3Primary immunodeficiency_Homo sapiens_hsa053403.07391404
4Allograft rejection_Homo sapiens_hsa053302.87121340
5Antigen processing and presentation_Homo sapiens_hsa046122.84654259
6Autoimmune thyroid disease_Homo sapiens_hsa053202.77013961
7T cell receptor signaling pathway_Homo sapiens_hsa046602.38979620
8Osteoclast differentiation_Homo sapiens_hsa043802.32655589
9Leishmaniasis_Homo sapiens_hsa051402.27063044
10B cell receptor signaling pathway_Homo sapiens_hsa046622.17331916
11Type I diabetes mellitus_Homo sapiens_hsa049402.16935515
12Staphylococcus aureus infection_Homo sapiens_hsa051502.14609476
13Viral myocarditis_Homo sapiens_hsa054162.05049370
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.93253115
15Platelet activation_Homo sapiens_hsa046111.90980484
16Hematopoietic cell lineage_Homo sapiens_hsa046401.86262212
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85034547
18Chemokine signaling pathway_Homo sapiens_hsa040621.77362732
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69454600
20Measles_Homo sapiens_hsa051621.69257496
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.61595320
22Malaria_Homo sapiens_hsa051441.56948724
23Tuberculosis_Homo sapiens_hsa051521.55669532
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52173977
25Acute myeloid leukemia_Homo sapiens_hsa052211.34562806
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32657062
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.31532548
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.29629266
29Non-small cell lung cancer_Homo sapiens_hsa052231.22664330
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16933956
31Toxoplasmosis_Homo sapiens_hsa051451.16499283
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12815807
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11134722
34Herpes simplex infection_Homo sapiens_hsa051681.10691629
35Asthma_Homo sapiens_hsa053101.09553138
36Phagosome_Homo sapiens_hsa041451.07309426
37Shigellosis_Homo sapiens_hsa051311.06841808
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06123416
39Legionellosis_Homo sapiens_hsa051341.05443785
40VEGF signaling pathway_Homo sapiens_hsa043701.03146484
41Influenza A_Homo sapiens_hsa051641.02236078
42Endocytosis_Homo sapiens_hsa041441.01677444
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01604252
44Rheumatoid arthritis_Homo sapiens_hsa053231.01187044
45Pancreatic cancer_Homo sapiens_hsa052120.99402526
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.98662362
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91466495
48Apoptosis_Homo sapiens_hsa042100.91123368
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.90110185
50TNF signaling pathway_Homo sapiens_hsa046680.89989789
51Hepatitis B_Homo sapiens_hsa051610.88810503
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81547399
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76232452
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76129626
55Salmonella infection_Homo sapiens_hsa051320.75280641
56Choline metabolism in cancer_Homo sapiens_hsa052310.74806905
57Chronic myeloid leukemia_Homo sapiens_hsa052200.73786615
58HTLV-I infection_Homo sapiens_hsa051660.72612440
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72306914
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.71553015
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69562228
62Pertussis_Homo sapiens_hsa051330.68818555
63African trypanosomiasis_Homo sapiens_hsa051430.68598143
64Regulation of autophagy_Homo sapiens_hsa041400.67546355
65Viral carcinogenesis_Homo sapiens_hsa052030.67390299
66Renal cell carcinoma_Homo sapiens_hsa052110.67058194
67Hepatitis C_Homo sapiens_hsa051600.66470049
68Endometrial cancer_Homo sapiens_hsa052130.65613716
69Epstein-Barr virus infection_Homo sapiens_hsa051690.64255199
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64200712
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.58976746
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58312508
73Rap1 signaling pathway_Homo sapiens_hsa040150.56849905
74Colorectal cancer_Homo sapiens_hsa052100.55533758
75Other glycan degradation_Homo sapiens_hsa005110.53594525
76Prolactin signaling pathway_Homo sapiens_hsa049170.52774821
77Notch signaling pathway_Homo sapiens_hsa043300.52772796
78Inositol phosphate metabolism_Homo sapiens_hsa005620.52060221
79Lysosome_Homo sapiens_hsa041420.50602186
80FoxO signaling pathway_Homo sapiens_hsa040680.49336808
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45634242
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44789834
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.44626163
84Ras signaling pathway_Homo sapiens_hsa040140.44239300
85GnRH signaling pathway_Homo sapiens_hsa049120.42750879
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.41492038
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41464568
88mTOR signaling pathway_Homo sapiens_hsa041500.41218372
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41128331
90MAPK signaling pathway_Homo sapiens_hsa040100.40344481
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39209475
92Long-term potentiation_Homo sapiens_hsa047200.34851892
93Amoebiasis_Homo sapiens_hsa051460.33878440
94Collecting duct acid secretion_Homo sapiens_hsa049660.32107625
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.31758374
96Glioma_Homo sapiens_hsa052140.30415138
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29916462
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28035407
99Insulin resistance_Homo sapiens_hsa049310.27633302
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.26366242

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »