KIR3DL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activated T cell proliferation (GO:0050798)9.89526409
2positive regulation of gamma-delta T cell activation (GO:0046645)6.06854826
3positive regulation of immune response to tumor cell (GO:0002839)6.01989208
4regulation of immune response to tumor cell (GO:0002837)6.01989208
5regulation of response to tumor cell (GO:0002834)6.01989208
6positive regulation of response to tumor cell (GO:0002836)6.01989208
7mucosal-associated lymphoid tissue development (GO:0048537)5.96182043
8Peyers patch development (GO:0048541)5.96182043
9cellular response to interleukin-15 (GO:0071350)5.91021992
10regulation of natural killer cell mediated immunity (GO:0002715)5.75107238
11regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.75107238
12positive regulation of natural killer cell mediated immunity (GO:0002717)5.66666428
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.60474931
14response to interleukin-15 (GO:0070672)5.58977065
15leukocyte aggregation (GO:0070486)5.50374978
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.48283922
17positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.41078778
18regulation of B cell differentiation (GO:0045577)5.31124085
19T cell migration (GO:0072678)5.30036152
20L-alpha-amino acid transmembrane transport (GO:1902475)5.26724746
21regulation of B cell receptor signaling pathway (GO:0050855)5.23934349
22regulation of gamma-delta T cell differentiation (GO:0045586)5.22480828
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.18849312
24natural killer cell differentiation (GO:0001779)5.10071259
25positive regulation of macrophage differentiation (GO:0045651)5.02539486
26negative T cell selection (GO:0043383)5.00336883
27regulation of gamma-delta T cell activation (GO:0046643)4.82608007
28negative thymic T cell selection (GO:0045060)4.79354696
29female mating behavior (GO:0060180)4.76824486
30ionotropic glutamate receptor signaling pathway (GO:0035235)4.76331598
31regulation of female receptivity (GO:0045924)4.73871785
32response to histamine (GO:0034776)4.71292704
33glutamate receptor signaling pathway (GO:0007215)4.71201410
34gamma-aminobutyric acid signaling pathway (GO:0007214)4.70072134
35antigen processing and presentation of endogenous antigen (GO:0019883)4.67318860
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.65204072
37regulation of glutamate receptor signaling pathway (GO:1900449)4.59578927
38positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.53071474
39dendritic spine morphogenesis (GO:0060997)4.51690666
40vocalization behavior (GO:0071625)4.48513417
41cellular extravasation (GO:0045123)4.41882952
42regulation of short-term neuronal synaptic plasticity (GO:0048172)4.39890005
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.35533007
44transmission of nerve impulse (GO:0019226)4.35335459
45positive regulation of granulocyte differentiation (GO:0030854)4.34880380
46regulation of leukocyte mediated cytotoxicity (GO:0001910)4.34760925
47neuron recognition (GO:0008038)4.30201019
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.30022453
49positive thymic T cell selection (GO:0045059)4.26978814
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.24440848
51T cell proliferation (GO:0042098)4.23317091
52G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.17174694
53positive regulation of T cell cytokine production (GO:0002726)4.16850123
54positive T cell selection (GO:0043368)4.10936948
55cytolysis (GO:0019835)4.10415806
56interferon-gamma production (GO:0032609)4.08562961
57axonal fasciculation (GO:0007413)4.08261518
58positive regulation of cell killing (GO:0031343)4.05871741
59mast cell activation (GO:0045576)4.04494733
60negative regulation of erythrocyte differentiation (GO:0045647)4.03680374
61regulation of vesicle fusion (GO:0031338)4.03677968
62glutamate secretion (GO:0014047)4.00818902
63locomotory exploration behavior (GO:0035641)3.98003314
64vesicle transport along microtubule (GO:0047496)3.97746281
65regulation of glutamate secretion (GO:0014048)3.96062123
66thymic T cell selection (GO:0045061)3.95168530
67neuron cell-cell adhesion (GO:0007158)3.93922221
68G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.90939397
69regulation of cell killing (GO:0031341)3.90890398
70calcium-mediated signaling using intracellular calcium source (GO:0035584)3.90682780
71proline transport (GO:0015824)3.86974243
72synaptic transmission, glutamatergic (GO:0035249)3.84382499
73protein localization to synapse (GO:0035418)3.82288127
74positive regulation of growth hormone secretion (GO:0060124)3.79009467
75positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.78199653
76T cell mediated immunity (GO:0002456)3.76628114
77neuron-neuron synaptic transmission (GO:0007270)3.72584932
78necroptotic process (GO:0070266)3.70926267
79T cell selection (GO:0045058)3.70490103
80natural killer cell activation (GO:0030101)3.68058797
81negative regulation of synaptic transmission, GABAergic (GO:0032229)3.67525414
82regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.65872990
83mast cell activation involved in immune response (GO:0002279)3.63742697
84mast cell degranulation (GO:0043303)3.63742697
85mitotic sister chromatid cohesion (GO:0007064)3.62937396
86antigen processing and presentation via MHC class Ib (GO:0002475)3.61389266
87opioid receptor signaling pathway (GO:0038003)3.60051534
88entrainment of circadian clock by photoperiod (GO:0043153)3.54398502
89detection of biotic stimulus (GO:0009595)3.53367648
90mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.51835580
91leukocyte degranulation (GO:0043299)3.51069092
92positive regulation of astrocyte differentiation (GO:0048711)3.50562914
93negative regulation of lymphocyte mediated immunity (GO:0002707)3.50114093
94positive regulation of T cell mediated cytotoxicity (GO:0001916)3.48131056
95hepatocyte apoptotic process (GO:0097284)3.47286441
96mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.46249436
97negative regulation of cell killing (GO:0031342)3.46002128
98negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.46002128
99NIK/NF-kappaB signaling (GO:0038061)3.43404807
100negative regulation of interleukin-12 production (GO:0032695)3.42344141
101regulation of protein kinase A signaling (GO:0010738)3.42149405
102regulation of T cell tolerance induction (GO:0002664)3.41116204
103positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.41058494
104positive regulation of lymphocyte mediated immunity (GO:0002708)3.37240177
105organelle transport along microtubule (GO:0072384)3.34876201
106long-term memory (GO:0007616)3.33506665
107synaptic vesicle exocytosis (GO:0016079)3.33407625
108ATP synthesis coupled proton transport (GO:0015986)3.33293475
109energy coupled proton transport, down electrochemical gradient (GO:0015985)3.33293475
110cytidine deamination (GO:0009972)3.32901204
111cytidine metabolic process (GO:0046087)3.32901204
112cytidine catabolic process (GO:0006216)3.32901204
113negative regulation of T cell mediated immunity (GO:0002710)3.30063496
114regulation of T cell mediated cytotoxicity (GO:0001914)3.28790440
115neutrophil activation involved in immune response (GO:0002283)3.24878526
116regulation of alpha-beta T cell proliferation (GO:0046640)3.23295240
117membrane depolarization during action potential (GO:0086010)3.22659955
118respiratory burst (GO:0045730)3.22101733
119regulation of necroptotic process (GO:0060544)3.21320463
120regulation of RIG-I signaling pathway (GO:0039535)3.20300234
121* cellular defense response (GO:0006968)3.18021823
122positive regulation of T cell mediated immunity (GO:0002711)3.16786411
123regulation of excitatory postsynaptic membrane potential (GO:0060079)3.15340601
124lymphocyte migration (GO:0072676)3.13792326
125tolerance induction (GO:0002507)3.13767539
126regulation of lymphocyte mediated immunity (GO:0002706)3.12693073
127programmed necrotic cell death (GO:0097300)3.12223964
128exploration behavior (GO:0035640)3.10616637
129regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.09436681
130innervation (GO:0060384)3.09388940
131positive regulation of leukocyte mediated immunity (GO:0002705)3.09372314
132pyrimidine ribonucleoside catabolic process (GO:0046133)3.07832813
133dendritic spine organization (GO:0097061)3.07617430
134negative regulation of necroptotic process (GO:0060546)3.07193210
135behavioral fear response (GO:0001662)3.06674795
136behavioral defense response (GO:0002209)3.06674795
137regulation of regulatory T cell differentiation (GO:0045589)3.06235588
138regulation of T cell receptor signaling pathway (GO:0050856)3.06225090
139positive regulation of tolerance induction (GO:0002645)3.05639192
140mature B cell differentiation (GO:0002335)3.05354368
141regulation of tolerance induction (GO:0002643)3.05278005
142lymphocyte proliferation (GO:0046651)3.04334114
143neurotransmitter secretion (GO:0007269)3.04248168
144neutrophil activation (GO:0042119)3.04172098
145regulation of T cell cytokine production (GO:0002724)3.04167783
146presynaptic membrane assembly (GO:0097105)3.03968967
147negative regulation of leukocyte mediated immunity (GO:0002704)3.03892655
148mononuclear cell proliferation (GO:0032943)3.03671880
149regulation of postsynaptic membrane potential (GO:0060078)3.01830455
150regulation of synaptic vesicle exocytosis (GO:2000300)3.01629505
151negative regulation of B cell activation (GO:0050869)3.00955820
152activation of protein kinase A activity (GO:0034199)3.00638267
153necrotic cell death (GO:0070265)3.00466432
154synaptic vesicle maturation (GO:0016188)2.98615174
155cellular potassium ion homeostasis (GO:0030007)2.98239380
156long-term synaptic potentiation (GO:0060291)2.96600591
157cochlea development (GO:0090102)2.95846755
158regulation of neuronal synaptic plasticity (GO:0048168)2.95806753
159neuronal action potential propagation (GO:0019227)2.95637660
160regulation of long-term neuronal synaptic plasticity (GO:0048169)2.93846677
161neurotransmitter-gated ion channel clustering (GO:0072578)2.93364157
162inner ear receptor cell development (GO:0060119)2.92492099
163negative regulation of amino acid transport (GO:0051956)2.90044874
164adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.89439881
165phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.88161131
166fear response (GO:0042596)2.87227897
167calcium ion import (GO:0070509)2.84880327
168regulation of dendritic spine morphogenesis (GO:0061001)2.84200078
169negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.83793392
170positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.82955312
171membrane depolarization (GO:0051899)2.82633314
172regulation of inositol phosphate biosynthetic process (GO:0010919)2.82134640
173neurotransmitter transport (GO:0006836)2.76623233
174regulation of calcium ion-dependent exocytosis (GO:0017158)2.75924235
175long term synaptic depression (GO:0060292)2.75153226
176cAMP-mediated signaling (GO:0019933)2.74995111
177gamma-aminobutyric acid transport (GO:0015812)2.73725420
178ATP hydrolysis coupled proton transport (GO:0015991)2.72883286
179energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.72883286
180regulation of synaptic vesicle transport (GO:1902803)2.72776843
181positive regulation of vesicle fusion (GO:0031340)2.72541721
182respiratory electron transport chain (GO:0022904)2.71085038
183cellular response to ammonium ion (GO:0071242)2.71042402
184regulation of synaptic plasticity (GO:0048167)2.70775648
185multi-organism reproductive behavior (GO:0044705)2.68023389
186positive regulation of cellular response to oxidative stress (GO:1900409)2.66859676
187positive regulation of response to oxidative stress (GO:1902884)2.66859676
188oxygen transport (GO:0015671)2.65172055
189electron transport chain (GO:0022900)2.64321949
190chemosensory behavior (GO:0007635)2.63874023
191neuromuscular process controlling posture (GO:0050884)2.63348733
192membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.62468997
193synaptic transmission (GO:0007268)2.62452444
194social behavior (GO:0035176)2.62374753
195intraspecies interaction between organisms (GO:0051703)2.62374753
196multicellular organismal signaling (GO:0035637)2.62235725
197nucleobase catabolic process (GO:0046113)2.62163572
198multicellular organismal reproductive behavior (GO:0033057)2.62074115

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.57667397
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.28231089
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.70673283
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.68923713
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.33957958
6RUNX_20019798_ChIP-Seq_JUKART_Human3.85707468
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.80743805
8GBX2_23144817_ChIP-Seq_PC3_Human3.78042755
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.75589425
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.50723465
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.46938407
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.41586400
13BP1_19119308_ChIP-ChIP_Hs578T_Human3.35091376
14MYB_26560356_Chip-Seq_TH2_Human3.26498876
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.21196273
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07986973
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.94232940
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.91396627
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91302870
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.89563035
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.82382019
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.81890163
23MYC_22102868_ChIP-Seq_BL_Human2.79451812
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.77651395
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.74775183
26MYB_26560356_Chip-Seq_TH1_Human2.67671482
27MAF_26560356_Chip-Seq_TH1_Human2.66877366
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.65668046
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52393270
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.49130243
31MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47135180
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45561732
33REST_21632747_ChIP-Seq_MESCs_Mouse2.43767859
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42799047
35SPI1_23547873_ChIP-Seq_NB4_Human2.38644080
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37291627
37* UTX_26944678_Chip-Seq_JUKART_Human2.31881928
38IRF8_27001747_Chip-Seq_BMDM_Mouse2.31827325
39GATA3_27048872_Chip-Seq_THYMUS_Human2.31696693
40TAF15_26573619_Chip-Seq_HEK293_Human2.30534051
41JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29588717
42MYB_21317192_ChIP-Seq_ERMYB_Mouse2.28609797
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28331336
44EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22959495
45RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22959495
46* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19710426
47P300_19829295_ChIP-Seq_ESCs_Human2.18928971
48SMAD_19615063_ChIP-ChIP_OVARY_Human2.15333625
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.14932139
50NOTCH1_21737748_ChIP-Seq_TLL_Human2.10889242
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09194693
52EED_16625203_ChIP-ChIP_MESCs_Mouse2.07691841
53EZH2_27304074_Chip-Seq_ESCs_Mouse2.07268473
54DROSHA_22980978_ChIP-Seq_HELA_Human2.06365495
55RUNX1_22412390_ChIP-Seq_EML_Mouse2.04425161
56SMAD4_21799915_ChIP-Seq_A2780_Human2.03816655
57MAF_26560356_Chip-Seq_TH2_Human2.00352524
58* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97198660
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96019451
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.91121005
61RARB_27405468_Chip-Seq_BRAIN_Mouse1.90397389
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.87042852
63SCL_19346495_ChIP-Seq_HPC-7_Human1.86140085
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85178723
65VDR_21846776_ChIP-Seq_THP-1_Human1.84479356
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.84304283
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83788293
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82995608
69GATA3_26560356_Chip-Seq_TH2_Human1.80430032
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79593772
71VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.77930917
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.77769156
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70294799
74GATA1_22025678_ChIP-Seq_K562_Human1.66054092
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.65938774
76VDR_24763502_ChIP-Seq_THP-1_Human1.63221522
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62965472
78TP53_16413492_ChIP-PET_HCT116_Human1.60945291
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60826302
80TCF7_22412390_ChIP-Seq_EML_Mouse1.57928319
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56810403
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56572240
83SPI1_23127762_ChIP-Seq_K562_Human1.53877677
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53480223
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52540644
86FUS_26573619_Chip-Seq_HEK293_Human1.51951649
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50955278
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50083589
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48969179
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48180914
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47372229
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.46656781
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46392278
94ZNF274_21170338_ChIP-Seq_K562_Hela1.45710417
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.43756030
96VDR_24787735_ChIP-Seq_THP-1_Human1.42897024
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40417939
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40291292
99VDR_22108803_ChIP-Seq_LS180_Human1.39458074
100AR_25329375_ChIP-Seq_VCAP_Human1.38599566
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38599325
102AR_21572438_ChIP-Seq_LNCaP_Human1.35682667
103SOX2_21211035_ChIP-Seq_LN229_Gbm1.35237298
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34958470
105KDM2B_26808549_Chip-Seq_JURKAT_Human1.33043038
106TP53_18474530_ChIP-ChIP_U2OS_Human1.32955970
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32221122
108PU_27001747_Chip-Seq_BMDM_Mouse1.29165348
109STAT3_23295773_ChIP-Seq_U87_Human1.28576542
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28560617
111KDM2B_26808549_Chip-Seq_DND41_Human1.28140428
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27139742
113CBX2_27304074_Chip-Seq_ESCs_Mouse1.27081503
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26544548
115RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24855439
116ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22887857
117PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22550311
118KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20695836
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19991032
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.19990801
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19909637
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18503746
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17807580
124NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17577390
125JUN_21703547_ChIP-Seq_K562_Human1.17356873
126CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17089282
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15042691
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13924545
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13604418
130GATA1_19941827_ChIP-Seq_MEL_Mouse1.12845611
131ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12727309
132HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12506401
133TCF4_23295773_ChIP-Seq_U87_Human1.12056986
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11369122
135GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11298097
136ER_23166858_ChIP-Seq_MCF-7_Human1.11131961
137NANOG_18555785_Chip-Seq_ESCs_Mouse1.10053836
138TRIM28_21343339_ChIP-Seq_HEK293_Human1.08882350
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08562877
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08469034
141BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08341828
142DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08194549
143CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07921430
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07653694
145RUNX2_22187159_ChIP-Seq_PCA_Human1.04251196
146GATA3_26560356_Chip-Seq_TH1_Human1.03465555
147CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02521374
148RNF2_27304074_Chip-Seq_NSC_Mouse1.02499487
149GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01551305
150SMAD4_21741376_ChIP-Seq_HESCs_Human1.01150196
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99479702
152CBP_20019798_ChIP-Seq_JUKART_Human0.99479702
153AR_19668381_ChIP-Seq_PC3_Human0.99031008
154CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97263773
155SMAD3_21741376_ChIP-Seq_HESCs_Human0.96947641
156MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96701830
157CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96227201
158SMAD3_21741376_ChIP-Seq_ESCs_Human0.96220416
159SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95614125
160YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95244737
161MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94431822
162EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93611208
163CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93316548
164P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93215349
165GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92459465
166CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91747474
167ARNT_22903824_ChIP-Seq_MCF-7_Human0.91445011
168RING1B_27294783_Chip-Seq_ESCs_Mouse0.90961785
169TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89568798
170PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88298598
171RING1B_27294783_Chip-Seq_NPCs_Mouse0.87858120
172KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.87762718
173DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87653115
174GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87218920
175SMAD4_21741376_ChIP-Seq_EPCs_Human0.86899642
176VDR_23849224_ChIP-Seq_CD4+_Human0.86728949
177ELK3_25401928_ChIP-Seq_HUVEC_Human0.86590072
178NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86374087
179NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86374087
180GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85295662
181PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85164822
182SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84770612
183GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84212546
184Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82513224
185NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80597594
186TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80486759
187NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80332606
188ELF1_20517297_ChIP-Seq_JURKAT_Human0.78916189
189GATA1_19941826_ChIP-Seq_K562_Human0.78568435
190SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78266907
191BCOR_27268052_Chip-Seq_Bcells_Human0.77249924
192SPI1_20517297_ChIP-Seq_HL60_Human0.76356906
193PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75958482
194PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75749997
195RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75676386
196BCL6_27268052_Chip-Seq_Bcells_Human0.75417843
197CIITA_25753668_ChIP-Seq_RAJI_Human0.74659564
198FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72464560
199GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72445215

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.56153761
2MP0003880_abnormal_central_pattern5.01971047
3MP0005670_abnormal_white_adipose5.01211820
4MP0005645_abnormal_hypothalamus_physiol4.36181646
5MP0001968_abnormal_touch/_nociception4.34644849
6MP0003635_abnormal_synaptic_transmissio3.76611022
7MP0005671_abnormal_response_to3.68535309
8MP0003763_abnormal_thymus_physiology3.66061204
9MP0002736_abnormal_nociception_after3.52732167
10MP0009745_abnormal_behavioral_response3.48305797
11MP0001835_abnormal_antigen_presentation3.43899153
12MP0003436_decreased_susceptibility_to3.43836496
13MP0001790_abnormal_immune_system3.22424547
14MP0005387_immune_system_phenotype3.22424547
15MP0003122_maternal_imprinting3.22315430
16MP0002735_abnormal_chemical_nociception3.19709250
17MP0006276_abnormal_autonomic_nervous3.00076330
18MP0000685_abnormal_immune_system2.98423665
19MP0002163_abnormal_gland_morphology2.93707661
20MP0003123_paternal_imprinting2.89042262
21MP0002063_abnormal_learning/memory/cond2.85541905
22MP0001800_abnormal_humoral_immune2.85040824
23MP0004270_analgesia2.79182316
24MP0002064_seizures2.78681718
25MP0006082_CNS_inflammation2.70514054
26MP0005000_abnormal_immune_tolerance2.62168664
27MP0002572_abnormal_emotion/affect_behav2.57141861
28MP0001501_abnormal_sleep_pattern2.51383871
29MP0002420_abnormal_adaptive_immunity2.50922370
30MP0001819_abnormal_immune_cell2.47671803
31MP0002723_abnormal_immune_serum2.46238446
32MP0009046_muscle_twitch2.41582088
33MP0003329_amyloid_beta_deposits2.39356823
34MP0005025_abnormal_response_to2.38521020
35MP0009333_abnormal_splenocyte_physiolog2.36113906
36MP0002734_abnormal_mechanical_nocicepti2.34577438
37MP0003724_increased_susceptibility_to2.25448979
38MP0002148_abnormal_hypersensitivity_rea2.23340570
39MP0001440_abnormal_grooming_behavior2.22096698
40MP0002398_abnormal_bone_marrow2.20854745
41MP0009785_altered_susceptibility_to2.20315569
42MP0002452_abnormal_antigen_presenting2.18918120
43MP0002822_catalepsy2.15522838
44MP0002272_abnormal_nervous_system2.14819949
45MP0002419_abnormal_innate_immunity2.05150518
46MP0003121_genomic_imprinting2.03199660
47MP0000716_abnormal_immune_system1.98793548
48MP0002733_abnormal_thermal_nociception1.94531756
49MP0003787_abnormal_imprinting1.94101794
50MP0002909_abnormal_adrenal_gland1.91737945
51MP0000703_abnormal_thymus_morphology1.91586480
52MP0003300_gastrointestinal_ulcer1.91431168
53MP0005423_abnormal_somatic_nervous1.89225961
54MP0004381_abnormal_hair_follicle1.88280381
55MP0005076_abnormal_cell_differentiation1.80596699
56MP0001905_abnormal_dopamine_level1.78658123
57MP0002067_abnormal_sensory_capabilities1.78469690
58MP0001873_stomach_inflammation1.76987802
59MP0001486_abnormal_startle_reflex1.75904282
60MP0002722_abnormal_immune_system1.73780921
61MP0010155_abnormal_intestine_physiology1.72728194
62MP0001529_abnormal_vocalization1.70485570
63MP0000689_abnormal_spleen_morphology1.67631840
64MP0001851_eye_inflammation1.64646384
65MP0001502_abnormal_circadian_rhythm1.62035267
66MP0002405_respiratory_system_inflammati1.59283906
67MP0001970_abnormal_pain_threshold1.57079647
68MP0000604_amyloidosis1.56866252
69MP0002184_abnormal_innervation1.56376428
70MP0004142_abnormal_muscle_tone1.56314139
71MP0004947_skin_inflammation1.55413085
72MP0010234_abnormal_vibrissa_follicle1.54645468
73MP0005646_abnormal_pituitary_gland1.52861635
74MP0003303_peritoneal_inflammation1.52397529
75MP0002429_abnormal_blood_cell1.51557224
76MP0000751_myopathy1.48122510
77MP0002876_abnormal_thyroid_physiology1.47926928
78MP0001845_abnormal_inflammatory_respons1.47577550
79MP0000778_abnormal_nervous_system1.47308594
80MP0003045_fibrosis1.47075293
81MP0005464_abnormal_platelet_physiology1.45014309
82MP0004924_abnormal_behavior1.41525997
83MP0005386_behavior/neurological_phenoty1.41525997
84MP0003866_abnormal_defecation1.40787609
85MP0001986_abnormal_taste_sensitivity1.39306270
86MP0002557_abnormal_social/conspecific_i1.36969659
87MP0002166_altered_tumor_susceptibility1.32571990
88MP0001533_abnormal_skeleton_physiology1.28419832
89MP0002396_abnormal_hematopoietic_system1.27244241
90MP0001727_abnormal_embryo_implantation1.26338018
91MP0005666_abnormal_adipose_tissue1.23018571
92MP0001984_abnormal_olfaction1.22026794
93MP0003075_altered_response_to1.21680064
94MP0002837_dystrophic_cardiac_calcinosis1.19515197
95MP0002066_abnormal_motor_capabilities/c1.12280126
96MP0004883_abnormal_blood_vessel1.04171801
97MP0003879_abnormal_hair_cell1.01856105
98MP0003172_abnormal_lysosome_physiology1.00836319
99MP0008469_abnormal_protein_level0.99590041
100MP0003690_abnormal_glial_cell0.99415612
101MP0006072_abnormal_retinal_apoptosis0.98722827
102MP0000631_abnormal_neuroendocrine_gland0.98139643
103MP0009780_abnormal_chondrocyte_physiolo0.97957478
104MP0002882_abnormal_neuron_morphology0.97943341
105MP0003693_abnormal_embryo_hatching0.96749867
106MP0004811_abnormal_neuron_physiology0.94623503
107MP0005623_abnormal_meninges_morphology0.94600140
108MP0000465_gastrointestinal_hemorrhage0.93230571
109MP0005075_abnormal_melanosome_morpholog0.91232236
110MP0000955_abnormal_spinal_cord0.90531426
111MP0005310_abnormal_salivary_gland0.89400007
112MP0001188_hyperpigmentation0.89200990
113MP0002006_tumorigenesis0.88512665
114MP0005379_endocrine/exocrine_gland_phen0.87018801
115MP0005535_abnormal_body_temperature0.86975554
116MP0001663_abnormal_digestive_system0.83161027
117MP0001666_abnormal_nutrient_absorption0.82957966
118MP0009763_increased_sensitivity_to0.82037161
119MP0004215_abnormal_myocardial_fiber0.81641878
120MP0008874_decreased_physiological_sensi0.81478070
121MP0005595_abnormal_vascular_smooth0.81400686
122MP0002970_abnormal_white_adipose0.78348207
123MP0003183_abnormal_peptide_metabolism0.78031203
124MP0002971_abnormal_brown_adipose0.77861463
125MP0000490_abnormal_crypts_of0.77690436
126MP0004742_abnormal_vestibular_system0.75000482
127MP0004808_abnormal_hematopoietic_stem0.74746544
128MP0002069_abnormal_eating/drinking_beha0.74530880
129MP0002277_abnormal_respiratory_mucosa0.73845717
130MP0000569_abnormal_digit_pigmentation0.73810161
131MP0002693_abnormal_pancreas_physiology0.73664049
132MP0004885_abnormal_endolymph0.73568855
133MP0002019_abnormal_tumor_incidence0.72407635
134MP0003633_abnormal_nervous_system0.72295702
135MP0008569_lethality_at_weaning0.71379984
136MP0003959_abnormal_lean_body0.71261958
137MP0001765_abnormal_ion_homeostasis0.71163534
138MP0009115_abnormal_fat_cell0.70758582
139MP0000015_abnormal_ear_pigmentation0.69027638
140MP0008872_abnormal_physiological_respon0.68761178
141MP0002152_abnormal_brain_morphology0.68743980
142MP0009764_decreased_sensitivity_to0.67894154
143MP0002132_abnormal_respiratory_system0.67738763
144MP0005551_abnormal_eye_electrophysiolog0.67251801
145MP0000858_altered_metastatic_potential0.66614559
146MP0002229_neurodegeneration0.65655457
147MP0003631_nervous_system_phenotype0.64905019
148MP0005164_abnormal_response_to0.64606224
149MP0008875_abnormal_xenobiotic_pharmacok0.64281097
150MP0004145_abnormal_muscle_electrophysio0.63720567
151MP0000920_abnormal_myelination0.62924625
152MP0008877_abnormal_DNA_methylation0.62360297
153MP0003868_abnormal_feces_composition0.61405235
154MP0005451_abnormal_body_composition0.61385439
155MP0010386_abnormal_urinary_bladder0.59651318
156MP0008961_abnormal_basal_metabolism0.59554996
157MP0003448_altered_tumor_morphology0.59396830
158MP0001853_heart_inflammation0.59195142
159MP0005375_adipose_tissue_phenotype0.58244744
160MP0004858_abnormal_nervous_system0.57523303
161MP0002254_reproductive_system_inflammat0.56111176
162MP0000230_abnormal_systemic_arterial0.55302064
163MP0004036_abnormal_muscle_relaxation0.54348477
164MP0003656_abnormal_erythrocyte_physiolo0.54203536
165MP0005448_abnormal_energy_balance0.53985498
166MP0006292_abnormal_olfactory_placode0.52914026
167MP0001963_abnormal_hearing_physiology0.51664701
168MP0005620_abnormal_muscle_contractility0.51232028
169MP0003634_abnormal_glial_cell0.50906848
170MP0002933_joint_inflammation0.50879027
171MP0004085_abnormal_heartbeat0.50215648
172MP0001177_atelectasis0.50199202
173MP0003221_abnormal_cardiomyocyte_apopto0.49450290
174MP0000749_muscle_degeneration0.49419860
175MP0001348_abnormal_lacrimal_gland0.49228693
176MP0002078_abnormal_glucose_homeostasis0.49027082
177MP0002998_abnormal_bone_remodeling0.48868279
178MP0009765_abnormal_xenobiotic_induced0.47235070
179MP0005360_urolithiasis0.47126952
180MP0001919_abnormal_reproductive_system0.46882244
181MP0008873_increased_physiological_sensi0.44974074
182MP0002075_abnormal_coat/hair_pigmentati0.44397591
183MP0008057_abnormal_DNA_replication0.43993825
184MP0009278_abnormal_bone_marrow0.39802924
185MP0005381_digestive/alimentary_phenotyp0.38878259
186MP0004233_abnormal_muscle_weight0.38147943
187MP0010307_abnormal_tumor_latency0.37821125

Predicted human phenotypes

RankGene SetZ-score
1Papilledema (HP:0001085)6.46347122
2Stomatitis (HP:0010280)6.20326601
3Mediastinal lymphadenopathy (HP:0100721)5.86042662
4Oligodactyly (hands) (HP:0001180)5.61796821
5Focal motor seizures (HP:0011153)5.61079120
6Febrile seizures (HP:0002373)5.56053070
7Polyphagia (HP:0002591)5.33993046
8Broad-based gait (HP:0002136)4.96687891
9Volvulus (HP:0002580)4.83702843
10Menstrual irregularities (HP:0000858)4.81429150
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.62438620
12Absence seizures (HP:0002121)4.49524329
13Atonic seizures (HP:0010819)4.43814999
14T lymphocytopenia (HP:0005403)4.43726901
15Elevated erythrocyte sedimentation rate (HP:0003565)4.41330916
16Myositis (HP:0100614)4.39177190
17Retrobulbar optic neuritis (HP:0100654)4.37299647
18Optic neuritis (HP:0100653)4.37299647
19Orchitis (HP:0100796)4.31839078
20Abnormality of T cell number (HP:0011839)4.28558181
21Epileptic encephalopathy (HP:0200134)4.26700094
22Focal seizures (HP:0007359)4.21239606
23Encephalitis (HP:0002383)4.09135448
24Recurrent cutaneous fungal infections (HP:0011370)4.06612667
25Chronic mucocutaneous candidiasis (HP:0002728)4.06612667
26Hypoproteinemia (HP:0003075)4.01934703
27Myokymia (HP:0002411)4.01381332
28Eczematoid dermatitis (HP:0000976)3.92708955
29Pulmonary infiltrates (HP:0002113)3.91397840
30Progressive cerebellar ataxia (HP:0002073)3.90744432
31Oligodactyly (HP:0012165)3.89509007
32Abnormal eating behavior (HP:0100738)3.80925590
33Panhypogammaglobulinemia (HP:0003139)3.77008654
34Dialeptic seizures (HP:0011146)3.75589710
35Neurofibrillary tangles (HP:0002185)3.73767594
36Recurrent viral infections (HP:0004429)3.72657398
37Abnormality of macrophages (HP:0004311)3.70011718
38Autoimmune hemolytic anemia (HP:0001890)3.68343626
39Supranuclear gaze palsy (HP:0000605)3.58508483
40Abnormality of T cells (HP:0002843)3.56328909
41Diastasis recti (HP:0001540)3.56089890
42Recurrent fungal infections (HP:0002841)3.54489152
43Cerebral inclusion bodies (HP:0100314)3.48043359
44Widely spaced teeth (HP:0000687)3.40313807
45Meningitis (HP:0001287)3.27634563
46Arterial thrombosis (HP:0004420)3.27058645
47Keratoconjunctivitis (HP:0001096)3.24288763
48Growth hormone excess (HP:0000845)3.22774060
49Acute necrotizing encephalopathy (HP:0006965)3.17730672
50Keratoconjunctivitis sicca (HP:0001097)3.17083518
51Generalized tonic-clonic seizures (HP:0002069)3.15336810
52Hyperventilation (HP:0002883)3.15253704
53Lymphopenia (HP:0001888)3.12643399
54Epileptiform EEG discharges (HP:0011182)3.11766357
55Decreased circulating renin level (HP:0003351)3.05101267
56Diplopia (HP:0000651)3.05011990
57Abnormality of binocular vision (HP:0011514)3.05011990
58Acute hepatic failure (HP:0006554)3.04721176
59Stenosis of the external auditory canal (HP:0000402)3.03616164
60Abnormality of cells of the lymphoid lineage (HP:0012140)3.00298274
61Recurrent abscess formation (HP:0002722)2.95534076
62Recurrent skin infections (HP:0001581)2.93462737
63Progressive macrocephaly (HP:0004481)2.92250633
64Recurrent bacterial skin infections (HP:0005406)2.88990255
65Pustule (HP:0200039)2.88226610
66Abnormality of T cell physiology (HP:0011840)2.87571225
67Amblyopia (HP:0000646)2.83925130
68IgG deficiency (HP:0004315)2.83206382
69Chest pain (HP:0100749)2.81836184
70Urinary bladder sphincter dysfunction (HP:0002839)2.81737054
71Drooling (HP:0002307)2.80998178
72Excessive salivation (HP:0003781)2.80998178
73Granulocytopenia (HP:0001913)2.76033474
74EEG with generalized epileptiform discharges (HP:0011198)2.75500362
75Clumsiness (HP:0002312)2.72888715
76Abnormal mitochondria in muscle tissue (HP:0008316)2.72362233
77Choroideremia (HP:0001139)2.69811833
78Increased IgM level (HP:0003496)2.68031408
79Truncal ataxia (HP:0002078)2.66149494
80Eosinophilia (HP:0001880)2.65530313
81Episodic fever (HP:0001954)2.65113565
82Impaired vibration sensation in the lower limbs (HP:0002166)2.65057907
83Testicular atrophy (HP:0000029)2.63891286
84Dysmetria (HP:0001310)2.63239774
85Vasculitis (HP:0002633)2.62572771
86Hypoplastic nipples (HP:0002557)2.61892687
87Abnormality of eosinophils (HP:0001879)2.61334703
88Scanning speech (HP:0002168)2.60249262
89Agammaglobulinemia (HP:0004432)2.59725222
90Mutism (HP:0002300)2.55415125
91Asplenia (HP:0001746)2.55028522
92Psychosis (HP:0000709)2.54754301
93Severe combined immunodeficiency (HP:0004430)2.54161561
94Hyperkalemia (HP:0002153)2.53896455
95Anxiety (HP:0000739)2.52275178
96Leukocytosis (HP:0001974)2.50652712
97Blepharitis (HP:0000498)2.46995605
98Visual hallucinations (HP:0002367)2.45140801
99Aplasia/Hypoplasia of the spleen (HP:0010451)2.44574261
100Inappropriate behavior (HP:0000719)2.42746548
101Oligodontia (HP:0000677)2.42336996
102Hypsarrhythmia (HP:0002521)2.41035850
103Acute encephalopathy (HP:0006846)2.40481931
104Bilateral sensorineural hearing impairment (HP:0008619)2.39567867
105Aplasia/Hypoplasia of the thymus (HP:0010515)2.39119857
106Gastrointestinal infarctions (HP:0005244)2.38364320
107Global brain atrophy (HP:0002283)2.38123167
108Hypoplastic labia majora (HP:0000059)2.35643754
109Recurrent bronchitis (HP:0002837)2.34531025
110Postural instability (HP:0002172)2.34257040
111Hypoventilation (HP:0002791)2.33522409
112Protruding tongue (HP:0010808)2.32248452
113Hypoplastic female external genitalia (HP:0012815)2.31016993
114Decreased electroretinogram (ERG) amplitude (HP:0000654)2.30726842
115Action tremor (HP:0002345)2.29459727
116Termporal pattern (HP:0011008)2.29331452
117Insidious onset (HP:0003587)2.29331452
118Blue irides (HP:0000635)2.26002968
119Abnormal hair whorl (HP:0010721)2.25673853
120Joint swelling (HP:0001386)2.25523543
121Exercise-induced myalgia (HP:0003738)2.25088627
122Amaurosis fugax (HP:0100576)2.24436732
123Increased circulating renin level (HP:0000848)2.24230270
124Sleep apnea (HP:0010535)2.24213661
125Spontaneous hematomas (HP:0007420)2.23868794
126Fair hair (HP:0002286)2.22254618
127Inflammation of the large intestine (HP:0002037)2.21645935
128Hemiparesis (HP:0001269)2.20030027
129Chronic diarrhea (HP:0002028)2.19303919
130Syncope (HP:0001279)2.18803007
131Exotropia (HP:0000577)2.18356148
132Colitis (HP:0002583)2.18315476
133Alveolar cell carcinoma (HP:0006519)2.17683536
134Split foot (HP:0001839)2.17421177
135Increased IgE level (HP:0003212)2.17149832
136Increased serum ferritin (HP:0003281)2.16940944
137Hypochromic anemia (HP:0001931)2.15607933
138Autoimmune thrombocytopenia (HP:0001973)2.14245740
139Lower limb amyotrophy (HP:0007210)2.13678241
140Abnormality of the labia majora (HP:0012881)2.13156055
141Abnormality of secondary sexual hair (HP:0009888)2.10882138
142Abnormality of the axillary hair (HP:0100134)2.10882138
143Cerebral hemorrhage (HP:0001342)2.10735068
144Combined immunodeficiency (HP:0005387)2.10615574
145Obstructive lung disease (HP:0006536)2.10377798
146Chronic obstructive pulmonary disease (HP:0006510)2.10377798
147Failure to thrive in infancy (HP:0001531)2.10273295
148Abnormality of the labia minora (HP:0012880)2.09934128
149Gastrointestinal inflammation (HP:0004386)2.09725127
150Papilloma (HP:0012740)2.08541515
151Verrucae (HP:0200043)2.08541515
152Urinary urgency (HP:0000012)2.08412963
153Fatigue (HP:0012378)2.07630783
154Generalized myoclonic seizures (HP:0002123)2.07408597
155Progressive inability to walk (HP:0002505)2.06721851
156Hemiplegia (HP:0002301)2.05988066
157Intellectual disability, progressive (HP:0006887)2.05014938
158Prolonged bleeding time (HP:0003010)2.03967537
159Abnormality of midbrain morphology (HP:0002418)2.03728779
160Molar tooth sign on MRI (HP:0002419)2.03728779
161Flat capital femoral epiphysis (HP:0003370)2.03356941
162Ureteral duplication (HP:0000073)2.03152846
163Esotropia (HP:0000565)2.02771072
164Anorexia (HP:0002039)2.02655770
165Abnormality of vision evoked potentials (HP:0000649)2.00662070
166Recurrent gram-negative bacterial infections (HP:0005420)2.00149140
167Neoplasm of the tracheobronchial system (HP:0100552)1.99782387
168Hemoptysis (HP:0002105)1.99432676
169Spastic gait (HP:0002064)1.98300531
170Abnormality of the common coagulation pathway (HP:0010990)1.97597368
171Flat occiput (HP:0005469)1.97306340
172Open mouth (HP:0000194)1.95948534
173Generalized hypopigmentation of hair (HP:0011358)1.95825351
174Pulmonary embolism (HP:0002204)1.95410007
175Poor eye contact (HP:0000817)1.94940051
176Abnormality of the corticospinal tract (HP:0002492)1.94272355
177Supernumerary bones of the axial skeleton (HP:0009144)1.93537992
178Spontaneous abortion (HP:0005268)1.92907581
179Depression (HP:0000716)1.92080309
180Mitochondrial inheritance (HP:0001427)1.90688977
181Intention tremor (HP:0002080)1.89306624
182Hyperactive renin-angiotensin system (HP:0000841)1.89080977
183Tented upper lip vermilion (HP:0010804)1.87458750
184Hammertoe (HP:0001765)1.87192895
185Labial hypoplasia (HP:0000066)1.86091696
186Infantile muscular hypotonia (HP:0008947)1.86028490
187Abnormality of salivation (HP:0100755)1.85243520
188Absent speech (HP:0001344)1.85073469
189Dysdiadochokinesis (HP:0002075)1.84045438
190Impaired vibratory sensation (HP:0002495)1.82963248
191Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.82775400
192Neuronal loss in central nervous system (HP:0002529)1.82716789
193Sporadic (HP:0003745)1.81311601
194Aggressive behavior (HP:0000718)1.80545928
195Increased serum pyruvate (HP:0003542)1.79992825
196Abnormality of glycolysis (HP:0004366)1.79992825
197Rapidly progressive (HP:0003678)1.79428604
198Difficulty running (HP:0009046)1.78708119
199Narrow nasal bridge (HP:0000446)1.77040958

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.98737924
2MAP3K94.39005236
3MAP4K14.21971105
4MAP3K133.96363505
5EPHA43.71169888
6PIK3CG3.41753222
7TXK3.12732458
8AKT32.95400051
9TEC2.68656504
10ZAP702.66483104
11MAP3K112.56430089
12TAOK12.53757004
13MAP3K42.44971193
14MAP2K42.34852793
15RIPK42.26528853
16MAP2K32.25916542
17MARK12.23486008
18MAP2K72.17667757
19ARAF2.10819252
20NTRK12.10521851
21TAOK22.08949940
22MINK11.99864656
23TNIK1.95153941
24ITK1.94184294
25NTRK21.92451510
26CSK1.90707538
27MAP3K31.84167388
28BTK1.81689944
29NME11.80442203
30CAMK2B1.78577789
31MAP3K121.77299222
32STK101.68867698
33DAPK21.63478847
34JAK11.58039898
35DAPK11.55711276
36FES1.52764556
37KSR21.52078242
38PAK31.51141846
39TYK21.50720757
40CAMKK21.47648696
41BRD41.44383005
42FER1.43593498
43JAK31.43281816
44TAOK31.39945236
45PLK21.37384959
46MAPK131.36956259
47IRAK41.35199046
48WNK41.34844969
49LCK1.34545593
50PRPF4B1.31166553
51SYK1.29682878
52SIK31.29670921
53CAMK2D1.28740393
54CAMK2A1.28043723
55CDK51.25834222
56BMPR21.25043597
57GRK71.25012210
58STK391.23513412
59IKBKE1.20846180
60KSR11.18497930
61NLK1.17874199
62TGFBR21.16149101
63HCK1.15138881
64BLK1.14773962
65SIK21.07352670
66MOS1.06005913
67CAMK2G1.05045714
68LATS21.04704673
69PDK11.03677407
70IKBKB1.03361618
71CASK1.03334788
72EPHA31.02554841
73CDK31.01542141
74ERBB30.92414414
75MAP3K70.92207843
76ERN10.87826442
77PRKCE0.85474842
78PAK60.84641083
79PNCK0.83402638
80PRKCG0.82556186
81UHMK10.80906663
82LYN0.80743916
83PKN10.80043217
84EPHB10.78843241
85JAK20.74688385
86TSSK60.73579958
87CAMKK10.71879973
88MAP2K60.71590647
89PIM10.70584418
90MAP3K20.69840151
91MAP3K50.67753371
92MST40.67228690
93MAP3K60.65199957
94GRK50.64735618
95MARK30.63904399
96STK110.63767904
97IRAK10.61750717
98FGFR20.60882273
99SRPK10.60440954
100FGFR30.60216392
101CDK40.59122893
102SGK10.57747908
103GRK60.57350138
104CSNK1G20.56707891
105FGR0.56207308
106CDK190.55304578
107KIT0.55048596
108PRKCH0.54908516
109TYRO30.52511167
110DYRK1B0.52141268
111TBK10.50022813
112MAP3K140.48831855
113PTK2B0.48421682
114TNK20.47736624
115KDR0.47549467
116PRKD30.43799760
117PRKACA0.43401099
118STK380.42899897
119WNK10.42789463
120PHKG10.42728949
121PHKG20.42728949
122MUSK0.42137618
123TESK20.42048081
124PBK0.41714256
125FYN0.41626562
126MARK20.40201608
127FRK0.39246638
128MAP2K10.39233873
129CDK140.37361324
130CSF1R0.37293078
131CDK150.36642735
132BRAF0.36639904
133RAF10.36189933
134OXSR10.36078828
135FGFR40.35935385
136SGK2230.34659552
137SGK4940.34659552
138PRKCA0.34434553
139CDK180.34393093
140HIPK20.34260236
141MAP3K10.33386337
142PIK3CA0.33131444
143PRKG10.32950468
144MAPK120.32123018
145RPS6KA30.31967827
146PRKCB0.31606233
147TRIB30.30907308
148ALK0.30493266
149PRKCQ0.30346033
150PRKCZ0.30062095
151RET0.29556491
152CAMK10.29130537
153EGFR0.28359691
154CDK11A0.28275808
155MAPK110.27479647
156PKN20.25654726
157MAPKAPK20.25602435
158MAPK70.25595228
159CHUK0.25007886
160CLK10.21596972
161LRRK20.20772685
162ZAK0.19459758
163IGF1R0.17497284
164SMG10.17373789
165PTK60.17273750

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.80300572
2Primary immunodeficiency_Homo sapiens_hsa053404.23436637
3* Graft-versus-host disease_Homo sapiens_hsa053324.20361210
4T cell receptor signaling pathway_Homo sapiens_hsa046603.58345504
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.00454555
6GABAergic synapse_Homo sapiens_hsa047272.96527959
7* Antigen processing and presentation_Homo sapiens_hsa046122.92621053
8Allograft rejection_Homo sapiens_hsa053302.80311520
9Circadian entrainment_Homo sapiens_hsa047132.68006538
10Autoimmune thyroid disease_Homo sapiens_hsa053202.58759737
11Long-term potentiation_Homo sapiens_hsa047202.52904223
12Morphine addiction_Homo sapiens_hsa050322.47000388
13Oxidative phosphorylation_Homo sapiens_hsa001902.44502432
14Glutamatergic synapse_Homo sapiens_hsa047242.42942865
15Amphetamine addiction_Homo sapiens_hsa050312.26440318
16NOD-like receptor signaling pathway_Homo sapiens_hsa046212.22299691
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.19154544
18Leishmaniasis_Homo sapiens_hsa051402.14398487
19Renin secretion_Homo sapiens_hsa049242.13324265
20Dopaminergic synapse_Homo sapiens_hsa047282.12789304
21Osteoclast differentiation_Homo sapiens_hsa043802.08836240
22Synaptic vesicle cycle_Homo sapiens_hsa047212.08592688
23Collecting duct acid secretion_Homo sapiens_hsa049662.05789277
24Long-term depression_Homo sapiens_hsa047302.05560049
25B cell receptor signaling pathway_Homo sapiens_hsa046622.04106698
26NF-kappa B signaling pathway_Homo sapiens_hsa040642.01853569
27Cocaine addiction_Homo sapiens_hsa050302.01165763
28Serotonergic synapse_Homo sapiens_hsa047261.95393259
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88528915
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.87672982
31Salivary secretion_Homo sapiens_hsa049701.84239703
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.83374208
33Alzheimers disease_Homo sapiens_hsa050101.82623912
34Measles_Homo sapiens_hsa051621.80589675
35TNF signaling pathway_Homo sapiens_hsa046681.76228090
36Hematopoietic cell lineage_Homo sapiens_hsa046401.75715332
37Taste transduction_Homo sapiens_hsa047421.74839304
38Parkinsons disease_Homo sapiens_hsa050121.72200792
39Cardiac muscle contraction_Homo sapiens_hsa042601.69725868
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.67888320
41Insulin secretion_Homo sapiens_hsa049111.67316224
42Cholinergic synapse_Homo sapiens_hsa047251.64145606
43Olfactory transduction_Homo sapiens_hsa047401.58634588
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54517175
45Tuberculosis_Homo sapiens_hsa051521.53289640
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52001519
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47499554
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46925996
49Oxytocin signaling pathway_Homo sapiens_hsa049211.46290316
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43937431
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.38957067
52Calcium signaling pathway_Homo sapiens_hsa040201.36482291
53Acute myeloid leukemia_Homo sapiens_hsa052211.35441673
54Toxoplasmosis_Homo sapiens_hsa051451.34178091
55Viral myocarditis_Homo sapiens_hsa054161.34059403
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33368150
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31887515
58Staphylococcus aureus infection_Homo sapiens_hsa051501.31324113
59Type II diabetes mellitus_Homo sapiens_hsa049301.29396530
60Shigellosis_Homo sapiens_hsa051311.28651255
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27583656
62Vibrio cholerae infection_Homo sapiens_hsa051101.25046906
63Gastric acid secretion_Homo sapiens_hsa049711.24152421
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23508326
65Huntingtons disease_Homo sapiens_hsa050161.22321708
66Intestinal immune network for IgA production_Homo sapiens_hsa046721.20051797
67Influenza A_Homo sapiens_hsa051641.17587650
68GnRH signaling pathway_Homo sapiens_hsa049121.17340083
69Pertussis_Homo sapiens_hsa051331.15457505
70Prion diseases_Homo sapiens_hsa050201.15130250
71African trypanosomiasis_Homo sapiens_hsa051431.14386858
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11219451
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10430320
74cAMP signaling pathway_Homo sapiens_hsa040241.10072154
75Estrogen signaling pathway_Homo sapiens_hsa049151.08865709
76Herpes simplex infection_Homo sapiens_hsa051681.07611266
77Malaria_Homo sapiens_hsa051441.06413173
78Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05085817
79Prolactin signaling pathway_Homo sapiens_hsa049171.01414356
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00630117
81Gap junction_Homo sapiens_hsa045400.99941441
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97901757
83Hepatitis B_Homo sapiens_hsa051610.97504343
84Non-small cell lung cancer_Homo sapiens_hsa052230.96934620
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.96392035
86Hepatitis C_Homo sapiens_hsa051600.94223593
87Epstein-Barr virus infection_Homo sapiens_hsa051690.92611459
88Apoptosis_Homo sapiens_hsa042100.90525457
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.88286886
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84026415
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.80323588
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80118745
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79770968
94Axon guidance_Homo sapiens_hsa043600.79546295
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78635289
96Dilated cardiomyopathy_Homo sapiens_hsa054140.77473829
97Colorectal cancer_Homo sapiens_hsa052100.76959052
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76316511
99Salmonella infection_Homo sapiens_hsa051320.72728863
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71632335
101Rheumatoid arthritis_Homo sapiens_hsa053230.71620288
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70808852
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70773509
104Melanogenesis_Homo sapiens_hsa049160.70216727
105Pancreatic cancer_Homo sapiens_hsa052120.69881603
106Glioma_Homo sapiens_hsa052140.69816012
107HTLV-I infection_Homo sapiens_hsa051660.68757165
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.68023817
109Type I diabetes mellitus_Homo sapiens_hsa049400.67281017
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66958844
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.65937324
112MAPK signaling pathway_Homo sapiens_hsa040100.62271353
113Thyroid hormone synthesis_Homo sapiens_hsa049180.61824275
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61373382
115Chronic myeloid leukemia_Homo sapiens_hsa052200.61262726
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61157324
117Asthma_Homo sapiens_hsa053100.60702899
118Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60217292
119Viral carcinogenesis_Homo sapiens_hsa052030.59508982
120Circadian rhythm_Homo sapiens_hsa047100.56443187
121Butanoate metabolism_Homo sapiens_hsa006500.56223230
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56046952
123Pancreatic secretion_Homo sapiens_hsa049720.55695052
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53567124
125ErbB signaling pathway_Homo sapiens_hsa040120.52813681
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52313922
127Glucagon signaling pathway_Homo sapiens_hsa049220.50883873
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49618265
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49571341
130Inositol phosphate metabolism_Homo sapiens_hsa005620.49538296
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49279917
132FoxO signaling pathway_Homo sapiens_hsa040680.48548741
133Choline metabolism in cancer_Homo sapiens_hsa052310.46368774
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45111001
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44785905
136Legionellosis_Homo sapiens_hsa051340.44660581
137Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43499790
138Bile secretion_Homo sapiens_hsa049760.41781714
139Endocytosis_Homo sapiens_hsa041440.39669105
140Phagosome_Homo sapiens_hsa041450.37883886
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37413329
142Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35217125
143VEGF signaling pathway_Homo sapiens_hsa043700.33400666
144Notch signaling pathway_Homo sapiens_hsa043300.33396330
145Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32838400
146Dorso-ventral axis formation_Homo sapiens_hsa043200.32364636
147Endometrial cancer_Homo sapiens_hsa052130.32352072
148Ras signaling pathway_Homo sapiens_hsa040140.32250069
149* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30542663
150Rap1 signaling pathway_Homo sapiens_hsa040150.30130333
151Sulfur metabolism_Homo sapiens_hsa009200.29980483
152Chemokine signaling pathway_Homo sapiens_hsa040620.29112418
153Regulation of autophagy_Homo sapiens_hsa041400.27356205
154Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.25734794
155Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24218917
156Fatty acid elongation_Homo sapiens_hsa000620.23406930
157Platelet activation_Homo sapiens_hsa046110.23384279
158Oocyte meiosis_Homo sapiens_hsa041140.22628674
159Adipocytokine signaling pathway_Homo sapiens_hsa049200.21351198
160Alcoholism_Homo sapiens_hsa050340.20437567
161Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20382751
162Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20211828
163Insulin signaling pathway_Homo sapiens_hsa049100.19910553
164Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.19805315
165Renal cell carcinoma_Homo sapiens_hsa052110.18197821
166HIF-1 signaling pathway_Homo sapiens_hsa040660.17584878
167mTOR signaling pathway_Homo sapiens_hsa041500.17331033
168Proteasome_Homo sapiens_hsa030500.15252532
169Prostate cancer_Homo sapiens_hsa052150.13379528

Most similar genes based on co-expression Upload to Enrichr

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