KIR2DL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450919.72716187
2DNA deamination (GO:0045006)9.26378909
3T cell migration (GO:0072678)7.41951364
4production of molecular mediator involved in inflammatory response (GO:0002532)6.76078954
5lymphocyte chemotaxis (GO:0048247)6.33092485
6signal complex assembly (GO:0007172)5.92626370
7pyrimidine nucleoside catabolic process (GO:0046135)5.84400697
8positive regulation of gamma-delta T cell activation (GO:0046645)5.37545442
9eosinophil chemotaxis (GO:0048245)5.14508927
10negative regulation of viral genome replication (GO:0045071)5.12824226
11negative regulation by host of viral transcription (GO:0043922)4.79384507
12macrophage chemotaxis (GO:0048246)4.78926205
13cellular response to interleukin-15 (GO:0071350)4.71969252
14lymphocyte migration (GO:0072676)4.71902754
15eosinophil migration (GO:0072677)4.64032620
16regulation of gamma-delta T cell differentiation (GO:0045586)4.62401963
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.57907500
18granulocyte activation (GO:0036230)4.57735173
19negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.44388910
20regulation of B cell receptor signaling pathway (GO:0050855)4.40058226
21positive regulation of macrophage differentiation (GO:0045651)4.37399630
22response to interleukin-15 (GO:0070672)4.34262626
23megakaryocyte development (GO:0035855)4.30634928
24negative regulation of T cell receptor signaling pathway (GO:0050860)4.24568443
25positive regulation of defense response to virus by host (GO:0002230)4.21578625
26positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)4.13648024
27positive regulation of translational initiation (GO:0045948)4.10356349
28positive regulation of T cell apoptotic process (GO:0070234)4.07241825
29negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.01254670
30regulation of gamma-delta T cell activation (GO:0046643)4.01004809
31negative regulation of execution phase of apoptosis (GO:1900118)4.00914443
32regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.00192058
33regulation of T cell receptor signaling pathway (GO:0050856)3.94460899
34regulation of lymphocyte chemotaxis (GO:1901623)3.90630278
35regulation of B cell differentiation (GO:0045577)3.89420098
36RNA localization (GO:0006403)3.82180822
37regulation of viral genome replication (GO:0045069)3.70733412
38lipoxygenase pathway (GO:0019372)3.67661434
39negative T cell selection (GO:0043383)3.66680120
40chemokine-mediated signaling pathway (GO:0070098)3.61755330
41negative regulation of viral process (GO:0048525)3.59705155
42positive regulation of interleukin-1 beta secretion (GO:0050718)3.57320228
43positive thymic T cell selection (GO:0045059)3.45115920
44metallo-sulfur cluster assembly (GO:0031163)3.43737576
45iron-sulfur cluster assembly (GO:0016226)3.43737576
46pyrimidine-containing compound catabolic process (GO:0072529)3.41015806
47positive T cell selection (GO:0043368)3.39239496
48leukocyte degranulation (GO:0043299)3.38695989
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.37511300
50positive regulation of interleukin-1 secretion (GO:0050716)3.36850462
51positive regulation of calcium-mediated signaling (GO:0050850)3.33650715
52regulation of interleukin-1 beta secretion (GO:0050706)3.26468278
53thymic T cell selection (GO:0045061)3.23544734
54positive regulation of lymphocyte migration (GO:2000403)3.22178743
55regulation of execution phase of apoptosis (GO:1900117)3.16884150
56positive regulation of interleukin-8 secretion (GO:2000484)3.16301485
57platelet formation (GO:0030220)3.15885724
58secretory granule organization (GO:0033363)3.15803273
59positive regulation of signal transduction by p53 class mediator (GO:1901798)3.15628081
60negative regulation of viral transcription (GO:0032897)3.15411201
61response to interferon-beta (GO:0035456)3.15172779
62negative thymic T cell selection (GO:0045060)3.13664044
63T cell selection (GO:0045058)3.12599759
64negative regulation of cell killing (GO:0031342)3.09313010
65negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.09313010
66negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.08791897
67sarcoplasmic reticulum calcium ion transport (GO:0070296)3.08412688
68positive regulation of T cell cytokine production (GO:0002726)3.07593490
69T cell costimulation (GO:0031295)3.04555337
70lymphocyte costimulation (GO:0031294)3.00453946
71neutrophil activation (GO:0042119)3.00163803
72positive regulation of lymphocyte apoptotic process (GO:0070230)2.96213576
73protein kinase B signaling (GO:0043491)2.94865694
74regulation of calcium-mediated signaling (GO:0050848)2.92792091
75regulation of chemokine biosynthetic process (GO:0045073)2.92787768
76monocyte chemotaxis (GO:0002548)2.91238612
77regulation of interleukin-1 secretion (GO:0050704)2.89294707
78regulation of interleukin-12 biosynthetic process (GO:0045075)2.88248789
79positive regulation of acute inflammatory response (GO:0002675)2.87784552
80interferon-gamma production (GO:0032609)2.87500300
81positive regulation of cAMP-mediated signaling (GO:0043950)2.86420961
82positive regulation of alpha-beta T cell proliferation (GO:0046641)2.86002291
83positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.84204313
84negative regulation of bone mineralization (GO:0030502)2.82428516
85cellular response to zinc ion (GO:0071294)2.81195071
86regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.80468323
87regulation of chronic inflammatory response (GO:0002676)2.78037001
88regulation of immunoglobulin secretion (GO:0051023)2.77338049
89positive regulation of leukocyte apoptotic process (GO:2000108)2.76731235
90positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.76331107
91leukocyte aggregation (GO:0070486)2.76008939
92regulation of activation of Janus kinase activity (GO:0010533)2.75223966
93establishment of protein localization to mitochondrial membrane (GO:0090151)2.74512583
94Arp2/3 complex-mediated actin nucleation (GO:0034314)2.73823564
95positive regulation of natural killer cell mediated immunity (GO:0002717)2.73585671
96positive regulation of interleukin-1 beta production (GO:0032731)2.73284243
97cytidine catabolic process (GO:0006216)12.5103390
98cytidine deamination (GO:0009972)12.5103390
99cytidine metabolic process (GO:0046087)12.5103390
100pyrimidine ribonucleoside catabolic process (GO:0046133)11.4851192

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human6.83384997
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.94342237
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.82707256
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.81246789
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.30803498
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.89541667
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.83864370
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.40931450
9MYB_26560356_Chip-Seq_TH2_Human3.40791780
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.31177799
11RUNX_20019798_ChIP-Seq_JUKART_Human2.96932470
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.94063805
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.86166091
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.60823793
15UTX_26944678_Chip-Seq_JUKART_Human2.57359957
16MYB_26560356_Chip-Seq_TH1_Human2.50891972
17MAF_26560356_Chip-Seq_TH1_Human2.50623324
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.43106970
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.39183545
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33032998
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.27086897
22GATA3_27048872_Chip-Seq_THYMUS_Human2.22883077
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.18542471
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.16005356
25CIITA_25753668_ChIP-Seq_RAJI_Human2.15944354
26GATA3_26560356_Chip-Seq_TH2_Human2.14473037
27SPI1_23547873_ChIP-Seq_NB4_Human2.12873319
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11672182
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.11554081
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09783278
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94635485
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.87958869
33MAF_26560356_Chip-Seq_TH2_Human1.86497584
34EGR1_19032775_ChIP-ChIP_M12_Human1.82146111
35SPI1_23127762_ChIP-Seq_K562_Human1.77157886
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.75989725
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.71069353
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.37558544
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36421696
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33916643
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31586335
42NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25608509
43MYC_22102868_ChIP-Seq_BL_Human1.24294226
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23338893
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23268152
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.16227918
47VDR_24763502_ChIP-Seq_THP-1_Human1.15660830
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14194835
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.09131992
50CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08758520
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.07775737
52BCL6_27268052_Chip-Seq_Bcells_Human1.06271352
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05736555
54VDR_24787735_ChIP-Seq_THP-1_Human1.04834540
55CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03566886
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00920705
57SCL_19346495_ChIP-Seq_HPC-7_Human0.99386478
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99331155
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98454543
60TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97703749
61RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96069555
62PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95768010
63FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94868803
64* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92935260
65TAF2_19829295_ChIP-Seq_ESCs_Human0.92563671
66GATA3_26560356_Chip-Seq_TH1_Human0.90764422
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90662196
68MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90271979
69FOXH1_21741376_ChIP-Seq_ESCs_Human0.89509684
70CTCF_20526341_ChIP-Seq_ESCs_Human0.89487193
71IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89398608
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88594989
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87278785
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86200377
75BCOR_27268052_Chip-Seq_Bcells_Human0.85902118
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85404626
77TDRD3_21172665_ChIP-Seq_MCF-7_Human0.85174825
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84632823
79FOXP3_21729870_ChIP-Seq_TREG_Human0.84102120
80P300_27268052_Chip-Seq_Bcells_Human0.83097692
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.81946467
82WDR5_24793694_ChIP-Seq_LNCAP_Human0.81326133
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80396082
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80293119
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79672678
86PU.1_20513432_ChIP-Seq_Bcells_Mouse0.78451787
87BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78413595
88EST1_17652178_ChIP-ChIP_JURKAT_Human0.77996097
89OCT4_20526341_ChIP-Seq_ESCs_Human0.77587728
90GATA1_19941827_ChIP-Seq_MEL_Mouse0.75423082
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.74981950
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74328885
93CTCF_26484167_Chip-Seq_Bcells_Mouse0.73578198
94SA1_27219007_Chip-Seq_Bcells_Human0.72852633
95TP53_16413492_ChIP-PET_HCT116_Human0.71860167
96FLI1_27457419_Chip-Seq_LIVER_Mouse0.70141049
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68860830
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68481499
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.68274572
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.67278543

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.29585917
2MP0003436_decreased_susceptibility_to4.60738755
3MP0006082_CNS_inflammation4.34345442
4MP0009785_altered_susceptibility_to3.89683089
5MP0003045_fibrosis3.64785688
6MP0003763_abnormal_thymus_physiology3.37382561
7MP0005000_abnormal_immune_tolerance3.31899667
8MP0001790_abnormal_immune_system3.05441898
9MP0005387_immune_system_phenotype3.05441898
10MP0009333_abnormal_splenocyte_physiolog3.01968140
11MP0001835_abnormal_antigen_presentation3.00004117
12MP0005025_abnormal_response_to2.87517884
13MP0002148_abnormal_hypersensitivity_rea2.83621453
14MP0001800_abnormal_humoral_immune2.79924549
15MP0000685_abnormal_immune_system2.77314524
16MP0002420_abnormal_adaptive_immunity2.58086747
17MP0002723_abnormal_immune_serum2.57989606
18MP0001819_abnormal_immune_cell2.56615284
19MP0002132_abnormal_respiratory_system2.37320123
20MP0002398_abnormal_bone_marrow2.14032390
21MP0002405_respiratory_system_inflammati2.14014777
22MP0002452_abnormal_antigen_presenting2.13056559
23MP0002419_abnormal_innate_immunity2.12616829
24MP0003878_abnormal_ear_physiology2.10723147
25MP0005377_hearing/vestibular/ear_phenot2.10723147
26MP0000703_abnormal_thymus_morphology1.99785771
27MP0003646_muscle_fatigue1.93638998
28MP0000716_abnormal_immune_system1.88915830
29MP0010155_abnormal_intestine_physiology1.84200789
30MP0003448_altered_tumor_morphology1.81268306
31MP0001533_abnormal_skeleton_physiology1.80778068
32MP0002722_abnormal_immune_system1.80313513
33MP0002877_abnormal_melanocyte_morpholog1.79952923
34MP0004947_skin_inflammation1.76978898
35MP0001845_abnormal_inflammatory_respons1.73865885
36MP0000689_abnormal_spleen_morphology1.58423286
37MP0003724_increased_susceptibility_to1.55365148
38MP0003252_abnormal_bile_duct1.54974626
39MP0003866_abnormal_defecation1.48824526
40MP0009764_decreased_sensitivity_to1.48503765
41MP0002429_abnormal_blood_cell1.48217592
42MP0002168_other_aberrant_phenotype1.46293110
43MP0002277_abnormal_respiratory_mucosa1.45099034
44MP0006035_abnormal_mitochondrial_morpho1.41633342
45MP0005083_abnormal_biliary_tract1.41319934
46MP0001485_abnormal_pinna_reflex1.38634714
47MP0003279_aneurysm1.29858493
48MP0004510_myositis1.27531401
49MP0001958_emphysema1.23274881
50MP0002933_joint_inflammation1.17812771
51MP0003300_gastrointestinal_ulcer1.17626712
52MP0008260_abnormal_autophagy1.16928255
53MP0003806_abnormal_nucleotide_metabolis1.15770080
54MP0008469_abnormal_protein_level1.15115609
55MP0005464_abnormal_platelet_physiology1.10481285
56MP0006054_spinal_hemorrhage1.08453727
57MP0002138_abnormal_hepatobiliary_system1.02110289
58MP0009763_increased_sensitivity_to0.99327503
59MP0009765_abnormal_xenobiotic_induced0.95383257
60MP0002102_abnormal_ear_morphology0.92640619
61MP0006036_abnormal_mitochondrial_physio0.91523795
62MP0001501_abnormal_sleep_pattern0.86702721
63MP0000569_abnormal_digit_pigmentation0.86130598
64MP0002136_abnormal_kidney_physiology0.83371680
65MP0000858_altered_metastatic_potential0.78109530
66MP0002163_abnormal_gland_morphology0.77384208
67MP0002019_abnormal_tumor_incidence0.73537987
68MP0003195_calcinosis0.73442144
69MP0002254_reproductive_system_inflammat0.70484519
70MP0001873_stomach_inflammation0.70150770
71MP0001188_hyperpigmentation0.68955095
72MP0005310_abnormal_salivary_gland0.62469156
73MP0002876_abnormal_thyroid_physiology0.60598547
74MP0003567_abnormal_fetal_cardiomyocyte0.59277777
75MP0002396_abnormal_hematopoietic_system0.59047879
76MP0005166_decreased_susceptibility_to0.58793961
77MP0005410_abnormal_fertilization0.58513773
78MP0001849_ear_inflammation0.56551702
79MP0003137_abnormal_impulse_conducting0.54723349
80MP0001348_abnormal_lacrimal_gland0.54463115
81MP0005395_other_phenotype0.54431457
82MP0005390_skeleton_phenotype0.53571180
83MP0001486_abnormal_startle_reflex0.50598429
84MP0000358_abnormal_cell_content/0.49789266
85MP0009046_muscle_twitch0.48102143
86MP0002693_abnormal_pancreas_physiology0.47972145
87MP0003950_abnormal_plasma_membrane0.46534055
88MP0002928_abnormal_bile_duct0.45973548
89MP0002998_abnormal_bone_remodeling0.45480272
90MP0001851_eye_inflammation0.45182980
91MP0002332_abnormal_exercise_endurance0.44935973
92MP0000678_abnormal_parathyroid_gland0.43337079
93MP0001986_abnormal_taste_sensitivity0.43130750
94MP0003786_premature_aging0.42643828
95MP0005623_abnormal_meninges_morphology0.40904016
96MP0001919_abnormal_reproductive_system0.40468204
97MP0005332_abnormal_amino_acid0.40334451
98MP0009643_abnormal_urine_homeostasis0.39673520
99MP0003303_peritoneal_inflammation0.36739249
100MP0005075_abnormal_melanosome_morpholog0.35882817

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)9.47349233
2Autoimmune hemolytic anemia (HP:0001890)7.44363722
3Increased IgM level (HP:0003496)5.90414152
4Abnormality of T cell number (HP:0011839)5.50089711
5Abnormal delayed hypersensitivity skin test (HP:0002963)5.47840271
6T lymphocytopenia (HP:0005403)5.20118389
7Abnormality of T cells (HP:0002843)4.91323248
8Recurrent abscess formation (HP:0002722)4.65795376
9Abnormality of T cell physiology (HP:0011840)4.52885952
10Mediastinal lymphadenopathy (HP:0100721)3.99260414
11Autoimmune thrombocytopenia (HP:0001973)3.90381774
12Severe combined immunodeficiency (HP:0004430)3.86527886
13Facial diplegia (HP:0001349)3.81975453
14Orchitis (HP:0100796)3.81064039
15Chronic obstructive pulmonary disease (HP:0006510)3.80727892
16Obstructive lung disease (HP:0006536)3.80727892
17Meningitis (HP:0001287)3.71589373
18Myositis (HP:0100614)3.70300133
19Gingivitis (HP:0000230)3.69850274
20Gastrointestinal infarctions (HP:0005244)3.58947426
21IgM deficiency (HP:0002850)3.45427788
22Eosinophilia (HP:0001880)3.39313041
23Elevated erythrocyte sedimentation rate (HP:0003565)3.31247456
24IgG deficiency (HP:0004315)3.22981875
25Abnormality of eosinophils (HP:0001879)3.21441803
26Optic neuritis (HP:0100653)3.19868756
27Retrobulbar optic neuritis (HP:0100654)3.19868756
28Panhypogammaglobulinemia (HP:0003139)3.12658510
29Combined immunodeficiency (HP:0005387)3.10563840
30Progressive inability to walk (HP:0002505)3.08303991
31Abnormality of macrophages (HP:0004311)3.04622743
32Granulocytopenia (HP:0001913)3.02419921
33Leukocytosis (HP:0001974)3.00575083
34Encephalitis (HP:0002383)2.93578715
35Hypergammaglobulinemia (HP:0010702)2.88577450
36Vasculitis (HP:0002633)2.83673840
37Eczematoid dermatitis (HP:0000976)2.82086643
38Cutaneous melanoma (HP:0012056)2.81430484
39Abnormality of B cell number (HP:0010975)2.66432206
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.64368691
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.64368691
42Recurrent cutaneous fungal infections (HP:0011370)2.63897664
43Chronic mucocutaneous candidiasis (HP:0002728)2.63897664
44Recurrent fungal infections (HP:0002841)2.61378381
45Dry hair (HP:0011359)2.60975497
46Acute hepatic failure (HP:0006554)2.56311969
47Ileus (HP:0002595)2.52301500
48Chest pain (HP:0100749)2.49285583
49Recurrent bronchitis (HP:0002837)2.48526349
50Reticulocytosis (HP:0001923)2.47669161
51Joint swelling (HP:0001386)2.47448423
52Thyroiditis (HP:0100646)2.45838281
53Hypoproteinemia (HP:0003075)2.42591871
54Recurrent bacterial skin infections (HP:0005406)2.39244545
55Urticaria (HP:0001025)2.33889756
56Pulmonary infiltrates (HP:0002113)2.22545623
57Keratoconjunctivitis sicca (HP:0001097)2.20571902
58Type I transferrin isoform profile (HP:0003642)2.18632158
59Premature loss of primary teeth (HP:0006323)2.17970396
60Abnormality of cells of the lymphoid lineage (HP:0012140)2.17414016
61Alveolar cell carcinoma (HP:0006519)2.16028578
62Increased IgE level (HP:0003212)2.15460927
63Gastrointestinal dysmotility (HP:0002579)2.13304076
64Pustule (HP:0200039)2.12419357
65Recurrent sinusitis (HP:0011108)2.12404944
66Abnormality of oral frenula (HP:0000190)2.09211749
67Recurrent viral infections (HP:0004429)2.06954476
68Decreased lacrimation (HP:0000633)2.06636579
69Impaired platelet aggregation (HP:0003540)2.05595908
70Abnormal platelet function (HP:0011869)2.05595908
71Arterial thrombosis (HP:0004420)2.02358968
72Hypoplasia of the thymus (HP:0000778)2.02184907
73Keratoconjunctivitis (HP:0001096)2.01436835
74Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01200847
75Anorexia (HP:0002039)2.00226177
76Chronic diarrhea (HP:0002028)1.98970643
77Premature graying of hair (HP:0002216)1.97653713
78Agammaglobulinemia (HP:0004432)1.97577076
79IgA deficiency (HP:0002720)1.97071546
80Hemoptysis (HP:0002105)1.95702715
81Gangrene (HP:0100758)1.95346216
82Recurrent skin infections (HP:0001581)1.95004839
83Lymphopenia (HP:0001888)1.94397389
84Abnormal auditory evoked potentials (HP:0006958)1.91691859
85Conjugated hyperbilirubinemia (HP:0002908)1.89431341
86Amyotrophic lateral sclerosis (HP:0007354)1.87088639
87Neoplasm of the tracheobronchial system (HP:0100552)1.86650396
88Vacuolated lymphocytes (HP:0001922)1.84095686
89Cerebral hypomyelination (HP:0006808)1.82926567
90B lymphocytopenia (HP:0010976)1.81417493
91Delusions (HP:0000746)1.80187930
92Hypochromic anemia (HP:0001931)1.77580933
93Sepsis (HP:0100806)1.76737520
94Peritonitis (HP:0002586)1.74794591
95Poor speech (HP:0002465)1.74067072
96Hypertensive crisis (HP:0100735)1.74003577
97Retinopathy (HP:0000488)1.72002240
98Lymphoma (HP:0002665)1.71314393
99Polyneuropathy (HP:0001271)1.70627528
100Episodic fever (HP:0001954)1.69805300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK16.24016268
2MAP3K124.19994356
3MAP4K14.16620558
4KDR3.98810869
5TXK3.91337181
6MAP3K113.85072557
7TESK23.82373445
8MAPKAPK33.56859588
9BLK3.06108460
10BMPR22.56033043
11CSK2.13034934
12CLK12.08418707
13CDK32.01280874
14FES2.00127212
15ERN11.87718824
16PRKCI1.86622492
17TESK11.75878344
18SYK1.67267683
19ZAP701.65369109
20IRAK41.54751855
21JAK31.54035637
22PRKCG1.45267229
23ITK1.40229455
24RIPK41.30913497
25DAPK11.29528419
26MAP3K51.29012709
27FGR1.28192858
28ACVR1B1.27627707
29MST41.19863295
30BTK1.15949116
31PIK3CA1.15865520
32PRKCQ1.14998516
33IKBKB1.13135551
34LYN1.12478535
35LCK1.10680394
36GRK60.99720294
37EPHB10.99238789
38PRKCE0.94931257
39FYN0.91346987
40CSF1R0.90975813
41PDPK10.83588236
42TAOK30.82368418
43LIMK10.81572084
44MAP3K10.78726217
45PTK60.78236312
46STK100.77825791
47MAP3K130.73786635
48FGFR10.68753487
49TEC0.65477182
50IKBKE0.65202898
51HCK0.63231005
52DAPK30.61366004
53PRKCD0.61197054
54FGFR20.58031072
55FGFR40.57645521
56PAK60.54760111
57ALK0.51196682
58GRK70.49468428
59KIT0.47693797
60JAK10.47580816
61BUB10.46377460
62TAOK10.44927592
63IGF1R0.42645266
64MAP2K70.42601382
65TGFBR20.42146265
66PRKCZ0.39009231
67CSNK1D0.36154659
68MAP3K100.35531100
69PRKCB0.35027035
70IRAK10.34082264
71FGFR30.33435766
72YES10.33235223
73PRKCA0.32964435
74MARK20.32211017
75MAP3K70.30365707
76SRC0.28132088
77PRKCH0.27007047
78MYLK0.26894367
79PRKD10.25867073
80MOS0.25122369
81TNK20.24622358
82MAP2K60.24429894
83KSR20.24295521
84RPS6KA50.23608527
85ILK0.22702252
86TRIB30.22570658
87JAK20.21889277
88RET0.21183489
89TBK10.21098549
90CHUK0.19208388
91MAP2K40.18476308
92GRK50.18015654
93FRK0.15641479
94CSNK2A10.15595542
95MAPKAPK20.15517702
96ROCK10.14707826
97BCR0.14075572
98PDK10.13916584
99INSR0.13153770
100ADRBK20.10388315

Predicted pathways (KEGG)

RankGene SetZ-score
1* Graft-versus-host disease_Homo sapiens_hsa053325.41630284
2Primary immunodeficiency_Homo sapiens_hsa053404.54859453
3* Antigen processing and presentation_Homo sapiens_hsa046124.19817714
4* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.89287091
5T cell receptor signaling pathway_Homo sapiens_hsa046603.02390542
6Proteasome_Homo sapiens_hsa030503.00827954
7Allograft rejection_Homo sapiens_hsa053302.99936190
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.85562839
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.72372042
10Autoimmune thyroid disease_Homo sapiens_hsa053202.42279510
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.19807287
12Osteoclast differentiation_Homo sapiens_hsa043801.90781173
13Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.85640452
14Type I diabetes mellitus_Homo sapiens_hsa049401.85170353
15Measles_Homo sapiens_hsa051621.74949266
16Hematopoietic cell lineage_Homo sapiens_hsa046401.71475897
17Rheumatoid arthritis_Homo sapiens_hsa053231.68545462
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66392277
19Asthma_Homo sapiens_hsa053101.65032411
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.59566577
21Leishmaniasis_Homo sapiens_hsa051401.58392087
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.55845285
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47747196
24Chemokine signaling pathway_Homo sapiens_hsa040621.46267172
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40916776
26Shigellosis_Homo sapiens_hsa051311.40043369
27Tyrosine metabolism_Homo sapiens_hsa003501.39294125
28Malaria_Homo sapiens_hsa051441.36969524
29Viral myocarditis_Homo sapiens_hsa054161.34314154
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.28995838
31TNF signaling pathway_Homo sapiens_hsa046681.27980131
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.27077253
33Oxidative phosphorylation_Homo sapiens_hsa001901.15487268
34Herpes simplex infection_Homo sapiens_hsa051681.10001548
35Parkinsons disease_Homo sapiens_hsa050121.02692988
36Salmonella infection_Homo sapiens_hsa051321.01926641
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98457208
38Tuberculosis_Homo sapiens_hsa051520.95031514
39Mineral absorption_Homo sapiens_hsa049780.91122872
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89942001
41Pertussis_Homo sapiens_hsa051330.89410563
42Legionellosis_Homo sapiens_hsa051340.83357250
43Epstein-Barr virus infection_Homo sapiens_hsa051690.80464136
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80399389
45Staphylococcus aureus infection_Homo sapiens_hsa051500.80009803
46Alzheimers disease_Homo sapiens_hsa050100.77232714
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77082817
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73525708
49Apoptosis_Homo sapiens_hsa042100.73366071
50B cell receptor signaling pathway_Homo sapiens_hsa046620.71754557
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63762985
52Regulation of autophagy_Homo sapiens_hsa041400.60886583
53ErbB signaling pathway_Homo sapiens_hsa040120.57580966
54Influenza A_Homo sapiens_hsa051640.57569485
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.57550924
56Peroxisome_Homo sapiens_hsa041460.57385251
57Toxoplasmosis_Homo sapiens_hsa051450.56822538
58Hepatitis C_Homo sapiens_hsa051600.56146395
59TGF-beta signaling pathway_Homo sapiens_hsa043500.54661862
60African trypanosomiasis_Homo sapiens_hsa051430.52916079
61mTOR signaling pathway_Homo sapiens_hsa041500.52404968
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.48517421
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46632080
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45373614
65N-Glycan biosynthesis_Homo sapiens_hsa005100.44141093
66Acute myeloid leukemia_Homo sapiens_hsa052210.43788764
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42017751
68Olfactory transduction_Homo sapiens_hsa047400.42000844
69Endocytosis_Homo sapiens_hsa041440.40682916
70ABC transporters_Homo sapiens_hsa020100.40019206
71Phototransduction_Homo sapiens_hsa047440.38232368
72Pentose phosphate pathway_Homo sapiens_hsa000300.37688765
73Cardiac muscle contraction_Homo sapiens_hsa042600.35656304
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34779481
75HTLV-I infection_Homo sapiens_hsa051660.34385745
76Phagosome_Homo sapiens_hsa041450.33537845
77Insulin resistance_Homo sapiens_hsa049310.32880242
78Galactose metabolism_Homo sapiens_hsa000520.32812943
79Hepatitis B_Homo sapiens_hsa051610.31921193
80Sulfur relay system_Homo sapiens_hsa041220.29563475
81HIF-1 signaling pathway_Homo sapiens_hsa040660.28910575
82Huntingtons disease_Homo sapiens_hsa050160.27613931
83Collecting duct acid secretion_Homo sapiens_hsa049660.27255359
84Choline metabolism in cancer_Homo sapiens_hsa052310.25386765
85Platelet activation_Homo sapiens_hsa046110.23412140
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22837822
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21814031
88Lysosome_Homo sapiens_hsa041420.21371198
89Fatty acid metabolism_Homo sapiens_hsa012120.20463387
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.17966707
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.17924650
92Systemic lupus erythematosus_Homo sapiens_hsa053220.16788687
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15389893
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15120935
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.14356424
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13577110
97Viral carcinogenesis_Homo sapiens_hsa052030.13064697
98Type II diabetes mellitus_Homo sapiens_hsa049300.12054312
99MAPK signaling pathway_Homo sapiens_hsa040100.11281372
100VEGF signaling pathway_Homo sapiens_hsa043700.11081987

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