KIF5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.94750415
2nuclear pore organization (GO:0006999)4.30171370
3hemidesmosome assembly (GO:0031581)3.86823260
4cell adhesion mediated by integrin (GO:0033627)3.81771132
5COPI coating of Golgi vesicle (GO:0048205)3.81260337
6Golgi transport vesicle coating (GO:0048200)3.81260337
7plasma membrane repair (GO:0001778)3.60149200
8pore complex assembly (GO:0046931)3.56735912
9synaptic vesicle maturation (GO:0016188)3.54454497
10retina vasculature morphogenesis in camera-type eye (GO:0061299)3.53384006
11mitotic sister chromatid cohesion (GO:0007064)3.49355682
12regulation of mitotic spindle organization (GO:0060236)3.49313468
13regulation of short-term neuronal synaptic plasticity (GO:0048172)3.41679161
14cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.37076991
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.32006379
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.28783846
17paraxial mesoderm development (GO:0048339)3.27529181
18mitotic cytokinesis (GO:0000281)3.24776024
19regulation of transforming growth factor beta2 production (GO:0032909)3.22132140
20cellular potassium ion homeostasis (GO:0030007)3.17338349
21mitotic chromosome condensation (GO:0007076)3.16350739
22activation of protein kinase A activity (GO:0034199)3.14632762
23detection of calcium ion (GO:0005513)3.13697479
24cytoskeletal anchoring at plasma membrane (GO:0007016)3.12740327
25membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.10098815
26protein targeting to Golgi (GO:0000042)3.09758419
27cytoskeleton-dependent cytokinesis (GO:0061640)3.09412577
28regulation of synaptic vesicle exocytosis (GO:2000300)3.07840674
29morphogenesis of an epithelial sheet (GO:0002011)3.07360939
30COPII vesicle coating (GO:0048208)3.06626921
31hippo signaling (GO:0035329)3.06177666
32sodium ion export (GO:0071436)3.06078736
33cell migration involved in sprouting angiogenesis (GO:0002042)3.03928858
34locomotory exploration behavior (GO:0035641)3.03540850
35cell communication by electrical coupling (GO:0010644)3.01693166
36neuronal action potential propagation (GO:0019227)3.01623020
37cell communication involved in cardiac conduction (GO:0086065)2.96884533
38bundle of His cell to Purkinje myocyte communication (GO:0086069)2.95163380
39layer formation in cerebral cortex (GO:0021819)2.90332922
40* vesicle transport along microtubule (GO:0047496)2.90322901
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.87847774
42retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.86802853
43relaxation of cardiac muscle (GO:0055119)2.85396037
44establishment of protein localization to Golgi (GO:0072600)2.85104687
45vascular endothelial growth factor signaling pathway (GO:0038084)2.84830128
46membrane repolarization during action potential (GO:0086011)2.78523745
47positive regulation of vesicle fusion (GO:0031340)2.75931707
48innervation (GO:0060384)2.74760957
49cell-substrate junction assembly (GO:0007044)2.73942343
50chemosensory behavior (GO:0007635)2.72908259
51synaptic vesicle exocytosis (GO:0016079)2.72892825
52retrograde transport, vesicle recycling within Golgi (GO:0000301)2.72006641
53membrane repolarization (GO:0086009)2.71248391
54synaptic vesicle docking involved in exocytosis (GO:0016081)2.68627135
55dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.67392139
56skin morphogenesis (GO:0043589)2.66030691
57regulation of spindle organization (GO:0090224)2.63023597
58protein localization to endosome (GO:0036010)2.62559427
59insulin secretion (GO:0030073)2.62450731
60glutamate secretion (GO:0014047)2.61535220
61sister chromatid segregation (GO:0000819)2.61291543
62regulation of RNA export from nucleus (GO:0046831)2.60215497
63protein maturation by protein folding (GO:0022417)2.59782396
64potassium ion import (GO:0010107)2.59733156
65regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.56736882
66regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.55776035
67notochord development (GO:0030903)2.55487844
68regulation of sister chromatid cohesion (GO:0007063)2.54018858
69negative regulation of potassium ion transmembrane transport (GO:1901380)2.52579594
70Notch signaling involved in heart development (GO:0061314)2.51601517
71regulation of synaptic vesicle transport (GO:1902803)2.51470893
72neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.50719920
73protein retention in ER lumen (GO:0006621)2.50105241
74asymmetric protein localization (GO:0008105)2.46861241
75potassium ion homeostasis (GO:0055075)2.44311402
76negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.43899725
77NLS-bearing protein import into nucleus (GO:0006607)2.43019474
78cerebellar Purkinje cell differentiation (GO:0021702)2.39889672
79embryonic foregut morphogenesis (GO:0048617)2.39824400
80positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.39813864
81regulation of nucleobase-containing compound transport (GO:0032239)2.39792999
82establishment of nucleus localization (GO:0040023)2.38195645
83adherens junction assembly (GO:0034333)2.38004737
84desmosome organization (GO:0002934)2.37978108
85coronary vasculature morphogenesis (GO:0060977)2.37831654
86* organelle transport along microtubule (GO:0072384)2.37650998
87protein localization to chromosome, centromeric region (GO:0071459)2.37625056
88regulation of clathrin-mediated endocytosis (GO:2000369)2.37570912
89cellular protein complex localization (GO:0034629)2.37267287
90regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.36988104
91peptidyl-lysine dimethylation (GO:0018027)2.36950064
92regulation of potassium ion transmembrane transport (GO:1901379)2.36208335
93membrane depolarization during action potential (GO:0086010)2.35959228
94mesodermal cell differentiation (GO:0048333)2.35331008
95maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.35212427
96negative regulation of anoikis (GO:2000811)2.35074644
97regulation of long-term neuronal synaptic plasticity (GO:0048169)2.34507575
98histone H2B ubiquitination (GO:0033523)2.34216366
99inner ear receptor cell development (GO:0060119)2.34071430
100gap junction assembly (GO:0016264)2.33818202
101regulation of neuronal synaptic plasticity (GO:0048168)2.33726685
102negative regulation of chondrocyte differentiation (GO:0032331)2.33412126
103neuromuscular process controlling balance (GO:0050885)2.32917472
104proline transport (GO:0015824)2.32717912
105nerve growth factor signaling pathway (GO:0038180)2.32270838
106regulation of dendritic spine morphogenesis (GO:0061001)2.31481662
107suckling behavior (GO:0001967)2.31270472
108ER overload response (GO:0006983)2.29727734
109neurotransmitter secretion (GO:0007269)2.29583729
110embryonic heart tube development (GO:0035050)2.29565558
111protein localization to microtubule (GO:0035372)2.27645579
112positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.27464508
113negative regulation of keratinocyte proliferation (GO:0010839)2.26522596
114ectodermal placode formation (GO:0060788)2.26329276
115regulation of growth hormone secretion (GO:0060123)2.26176956
116Golgi to plasma membrane transport (GO:0006893)2.25297559
117dendrite morphogenesis (GO:0048813)2.24900350
118mitotic sister chromatid segregation (GO:0000070)2.24849179
119regulation of synapse structural plasticity (GO:0051823)2.24526838
120protein localization to Golgi apparatus (GO:0034067)2.24369860
121regulation of potassium ion transmembrane transporter activity (GO:1901016)2.24057625
122dendritic spine organization (GO:0097061)2.23301878
123activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.23049133
124regulation of heart rate by cardiac conduction (GO:0086091)2.22471138
125apical protein localization (GO:0045176)2.22162058
126regulation of NFAT protein import into nucleus (GO:0051532)2.21760639
127negative regulation of hormone metabolic process (GO:0032351)2.21586934
128negative regulation of hormone biosynthetic process (GO:0032353)2.21586934
129glucocorticoid receptor signaling pathway (GO:0042921)2.21342253
130Golgi to plasma membrane protein transport (GO:0043001)2.21282932
131negative regulation of DNA repair (GO:0045738)2.20982792
132regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.20403718
133cytokinesis (GO:0000910)2.20351826
134regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.20334072
135regulation of membrane repolarization (GO:0060306)2.19560069
136chondrocyte proliferation (GO:0035988)2.19122558
137cardiac conduction (GO:0061337)2.18611793
138wound healing, spreading of epidermal cells (GO:0035313)2.18336653
139focal adhesion assembly (GO:0048041)2.18115886
140cell-substrate adherens junction assembly (GO:0007045)2.18115886
141vesicle coating (GO:0006901)2.17872299
142cytoplasmic mRNA processing body assembly (GO:0033962)2.17571579
143cerebellar Purkinje cell layer development (GO:0021680)2.17567460
144embryonic process involved in female pregnancy (GO:0060136)2.17051897
145negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.17015729
146establishment of chromosome localization (GO:0051303)2.16890047
147metaphase plate congression (GO:0051310)2.16708476
148positive regulation of potassium ion transmembrane transport (GO:1901381)2.16558794
149mitotic spindle organization (GO:0007052)2.16493050
150regulation of calcium ion transmembrane transport (GO:1903169)2.16452254
151regulation of calcium ion transmembrane transporter activity (GO:1901019)2.16452254
152insulin-like growth factor receptor signaling pathway (GO:0048009)2.16339332
153epithelial cell-cell adhesion (GO:0090136)2.16239002
154growth hormone secretion (GO:0030252)2.16101160
155collagen fibril organization (GO:0030199)2.16095757
156mitotic metaphase plate congression (GO:0007080)2.16039977
157surfactant homeostasis (GO:0043129)2.15958138
158regulation of vesicle fusion (GO:0031338)2.15713302
159axon cargo transport (GO:0008088)2.15669283
160blood vessel endothelial cell migration (GO:0043534)2.15647613
161myoblast fusion (GO:0007520)2.15452788
162DNA unwinding involved in DNA replication (GO:0006268)2.14682681
163* positive regulation of potassium ion transport (GO:0043268)2.14667991
164negative regulation of dendrite morphogenesis (GO:0050774)2.14150193
165positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.14103295
166regulation of ARF protein signal transduction (GO:0032012)2.13836512
167cellular sodium ion homeostasis (GO:0006883)2.13694875
168relaxation of muscle (GO:0090075)2.13621368
169stress fiber assembly (GO:0043149)2.13508669
170positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.13433770
171positive regulation of mitotic sister chromatid separation (GO:1901970)2.13433770
172positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.13433770
173axonal fasciculation (GO:0007413)2.13326038
174exploration behavior (GO:0035640)2.13234475
175embryonic retina morphogenesis in camera-type eye (GO:0060059)2.12454719
176regulation of Rac protein signal transduction (GO:0035020)2.12380891
177sprouting angiogenesis (GO:0002040)2.11683063
178vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.10577447
179substrate-dependent cell migration (GO:0006929)2.10130889
180ganglion development (GO:0061548)2.08759531
181cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.07588521
182lens morphogenesis in camera-type eye (GO:0002089)2.06833985
183regulation of glucose import in response to insulin stimulus (GO:2001273)2.05223632
184membrane assembly (GO:0071709)2.04591551
185ventricular cardiac muscle cell development (GO:0055015)2.04546466
186regulation of cardioblast differentiation (GO:0051890)2.04473091
187cell surface receptor signaling pathway involved in heart development (GO:0061311)2.04271470

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.23727085
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.78403764
3AR_21909140_ChIP-Seq_LNCAP_Human3.65455674
4EZH2_22144423_ChIP-Seq_EOC_Human2.81707728
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.69407988
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.51212726
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.29852003
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.15934725
9PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.15893043
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15031323
11* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.13797068
12TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.09932004
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.04027262
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95468379
15WT1_19549856_ChIP-ChIP_CCG9911_Human1.93357801
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89357993
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86428672
18GBX2_23144817_ChIP-Seq_PC3_Human1.85446074
19E2F7_22180533_ChIP-Seq_HELA_Human1.85335936
20SALL4_18804426_ChIP-ChIP_XEN_Mouse1.85312849
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85026476
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83859195
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83859195
24* BRD4_25478319_ChIP-Seq_HGPS_Human1.83440556
25SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.80149076
26SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.79836295
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.79836295
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75796383
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74353232
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.73222410
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.70142701
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66840917
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.65534123
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63592325
35NR3C1_23031785_ChIP-Seq_PC12_Mouse1.62387875
36ZNF274_21170338_ChIP-Seq_K562_Hela1.62315703
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62121326
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.58693369
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58256807
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57588421
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56482127
42AHR_22903824_ChIP-Seq_MCF-7_Human1.56447167
43DROSHA_22980978_ChIP-Seq_HELA_Human1.54435962
44* PIAS1_25552417_ChIP-Seq_VCAP_Human1.53253620
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52295178
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51631228
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49330114
48TP53_16413492_ChIP-PET_HCT116_Human1.49195944
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47785690
50* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47737546
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.47508824
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.46063117
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.45721053
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.45085737
55* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44867745
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.43437162
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.41713912
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39811543
59STAT3_23295773_ChIP-Seq_U87_Human1.38566166
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37485128
61TP53_18474530_ChIP-ChIP_U2OS_Human1.35583488
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33312020
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.32436488
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32254671
65AR_21572438_ChIP-Seq_LNCaP_Human1.31922139
66ZNF263_19887448_ChIP-Seq_K562_Human1.31523723
67FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30611717
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30240360
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30240360
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29256734
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28773137
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28324419
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28042064
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27558087
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27295861
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27273736
77EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.26971316
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.26553895
79BCAT_22108803_ChIP-Seq_LS180_Human1.26144654
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25950300
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25838442
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25119807
83REST_21632747_ChIP-Seq_MESCs_Mouse1.24944672
84TCF4_18268006_ChIP-ChIP_LS174T_Human1.24296149
85ESR1_21235772_ChIP-Seq_MCF-7_Human1.23908237
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22651139
87* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.22511807
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20637913
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20205966
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.19260350
91CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18991480
92CHD1_26751641_Chip-Seq_LNCaP_Human1.18284013
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.18185349
94NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.17213213
95* AR_19668381_ChIP-Seq_PC3_Human1.16930588
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16846352
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15880572
98FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15512459
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.15318187
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.15276637
101* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14932619
102HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14629411
103KDM2B_26808549_Chip-Seq_K562_Human1.14309042
104* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13971586
105SMAD3_21741376_ChIP-Seq_EPCs_Human1.13723242
106CJUN_26792858_Chip-Seq_BT549_Human1.13672171
107TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.12961246
108MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12953129
109UBF1/2_26484160_Chip-Seq_HMECs_Human1.12398364
110* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11661860
111CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10977792
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10720210
113SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10377848
114NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10365766
115EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09505605
116MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09284484
117* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08739076
118AR_25329375_ChIP-Seq_VCAP_Human1.07880045
119* RXR_22108803_ChIP-Seq_LS180_Human1.07429779
120* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07233225
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07034510
122ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06606366
123E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06425040
124CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05070726
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05016439
126RING1B_27294783_Chip-Seq_NPCs_Mouse1.03754855
127CLOCK_20551151_ChIP-Seq_293T_Human1.03532909
128* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03508654
129SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02967876
130P300_19829295_ChIP-Seq_ESCs_Human1.02910148
131SOX17_20123909_ChIP-Seq_XEN_Mouse1.02865578
132FUS_26573619_Chip-Seq_HEK293_Human1.02847351
133TCF4_23295773_ChIP-Seq_U87_Human1.02278723
134SOX2_20726797_ChIP-Seq_SW620_Human1.02222105
135SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01713207
136* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01466370
137CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99487820
138ISL1_27105846_Chip-Seq_CPCs_Mouse0.99051021
139SMAD3_21741376_ChIP-Seq_HESCs_Human0.98864376
140RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98814182
141* FOXO3_23340844_ChIP-Seq_DLD1_Human0.98626223
142FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98420027
143MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97974967
144SOX9_26525672_Chip-Seq_HEART_Mouse0.97211256
145GATA4_21415370_ChIP-Seq_HL-1_Mouse0.97049573
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96886446
147* TBX20_22328084_ChIP-Seq_HEART_Mouse0.96734717
148* TBX20_22080862_ChIP-Seq_HEART_Mouse0.96734717
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96698195
150GATA2_21666600_ChIP-Seq_HMVEC_Human0.96529878
151TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96428241
152* TP63_23658742_ChIP-Seq_EP156T_Human0.96068660
153GF1B_26923725_Chip-Seq_HPCs_Mouse0.95643192
154TAF15_26573619_Chip-Seq_HEK293_Human0.95414326
155TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95262462
156ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94502917
157TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93996361
158CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93860361

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.70426783
2MP0002877_abnormal_melanocyte_morpholog3.42121061
3MP0009780_abnormal_chondrocyte_physiolo3.27583358
4MP0004859_abnormal_synaptic_plasticity3.21428977
5MP0000013_abnormal_adipose_tissue3.08053602
6MP0004270_analgesia3.01562719
7MP0002909_abnormal_adrenal_gland2.70036071
8MP0003283_abnormal_digestive_organ2.52316176
9MP0010368_abnormal_lymphatic_system2.37916462
10MP0005409_darkened_coat_color2.19383357
11MP0003950_abnormal_plasma_membrane2.15762978
12MP0005623_abnormal_meninges_morphology2.13593989
13MP0001299_abnormal_eye_distance/2.00674356
14MP0003635_abnormal_synaptic_transmissio1.97775841
15MP0002837_dystrophic_cardiac_calcinosis1.93461416
16MP0004858_abnormal_nervous_system1.85545206
17MP0002734_abnormal_mechanical_nocicepti1.82213209
18MP0003300_gastrointestinal_ulcer1.68349107
19MP0002735_abnormal_chemical_nociception1.61815496
20MP0003045_fibrosis1.59348369
21MP0004272_abnormal_basement_membrane1.54573099
22MP0000003_abnormal_adipose_tissue1.53951968
23MP0000733_abnormal_muscle_development1.53816588
24MP0010386_abnormal_urinary_bladder1.51749816
25MP0008057_abnormal_DNA_replication1.50299325
26MP0001968_abnormal_touch/_nociception1.47240303
27MP0003880_abnormal_central_pattern1.45297422
28MP0002063_abnormal_learning/memory/cond1.44185188
29MP0005275_abnormal_skin_tensile1.42477802
30MP0004145_abnormal_muscle_electrophysio1.39091313
31MP0002733_abnormal_thermal_nociception1.38080318
32MP0002896_abnormal_bone_mineralization1.38051053
33MP0004043_abnormal_pH_regulation1.36951907
34MP0000762_abnormal_tongue_morphology1.36128001
35MP0004084_abnormal_cardiac_muscle1.35506218
36MP0010352_gastrointestinal_tract_polyps1.35398726
37MP0004215_abnormal_myocardial_fiber1.31795970
38MP0002009_preneoplasia1.31644251
39MP0002060_abnormal_skin_morphology1.27222265
40MP0002234_abnormal_pharynx_morphology1.27161415
41MP0003705_abnormal_hypodermis_morpholog1.27070875
42MP0003122_maternal_imprinting1.24754490
43MP0009745_abnormal_behavioral_response1.23532698
44MP0003221_abnormal_cardiomyocyte_apopto1.21359534
45MP0000749_muscle_degeneration1.21193134
46MP0001944_abnormal_pancreas_morphology1.21187644
47MP0000537_abnormal_urethra_morphology1.20956966
48MP0002184_abnormal_innervation1.20877933
49MP0001970_abnormal_pain_threshold1.20216325
50MP0002697_abnormal_eye_size1.18837951
51MP0009046_muscle_twitch1.18311457
52MP0000569_abnormal_digit_pigmentation1.18144080
53MP0006138_congestive_heart_failure1.17889137
54MP0003787_abnormal_imprinting1.17748730
55MP0005257_abnormal_intraocular_pressure1.17303653
56MP0009053_abnormal_anal_canal1.16964261
57MP0005187_abnormal_penis_morphology1.16260065
58MP0003183_abnormal_peptide_metabolism1.15469363
59* MP0002084_abnormal_developmental_patter1.15110389
60MP0004811_abnormal_neuron_physiology1.12465053
61MP0001915_intracranial_hemorrhage1.12446834
62MP0002272_abnormal_nervous_system1.12179784
63MP0003890_abnormal_embryonic-extraembry1.11868550
64MP0002269_muscular_atrophy1.11553853
65MP0003937_abnormal_limbs/digits/tail_de1.11452876
66MP0003941_abnormal_skin_development1.11074609
67MP0002693_abnormal_pancreas_physiology1.10020494
68MP0000383_abnormal_hair_follicle1.09571740
69MP0002064_seizures1.09144303
70MP0003123_paternal_imprinting1.08662083
71MP0008961_abnormal_basal_metabolism1.08561399
72MP0003984_embryonic_growth_retardation1.08519618
73MP0000767_abnormal_smooth_muscle1.08270442
74MP0001672_abnormal_embryogenesis/_devel1.06626729
75MP0005380_embryogenesis_phenotype1.06626729
76MP0001730_embryonic_growth_arrest1.06530010
77MP0000751_myopathy1.06344439
78MP0000579_abnormal_nail_morphology1.06290184
79MP0000516_abnormal_urinary_system1.06247955
80MP0005367_renal/urinary_system_phenotyp1.06247955
81MP0005076_abnormal_cell_differentiation1.06230139
82MP0000462_abnormal_digestive_system1.05184762
83MP0002088_abnormal_embryonic_growth/wei1.04330642
84MP0010630_abnormal_cardiac_muscle1.02851546
85MP0001177_atelectasis1.02361174
86MP0002086_abnormal_extraembryonic_tissu1.01844426
87MP0009697_abnormal_copulation1.01560729
88MP0004233_abnormal_muscle_weight1.00817061
89MP0000955_abnormal_spinal_cord1.00031650
90MP0001958_emphysema0.99769234
91MP0002092_abnormal_eye_morphology0.99668400
92MP0004185_abnormal_adipocyte_glucose0.99044859
93MP0004957_abnormal_blastocyst_morpholog0.98772319
94MP0003115_abnormal_respiratory_system0.98239893
95MP0003755_abnormal_palate_morphology0.96940618
96MP0002572_abnormal_emotion/affect_behav0.96683649
97MP0003566_abnormal_cell_adhesion0.96629233
98MP0008438_abnormal_cutaneous_collagen0.95042676
99MP0004197_abnormal_fetal_growth/weight/0.94734811
100MP0002067_abnormal_sensory_capabilities0.94721013
101MP0010678_abnormal_skin_adnexa0.94460765
102MP0004036_abnormal_muscle_relaxation0.93452996
103MP0002736_abnormal_nociception_after0.93443878
104MP0002796_impaired_skin_barrier0.92821189
105MP0005023_abnormal_wound_healing0.92435410
106MP0004484_altered_response_of0.91455893
107MP0000432_abnormal_head_morphology0.90398045
108MP0003453_abnormal_keratinocyte_physiol0.90156167
109MP0003279_aneurysm0.89831922
110MP0006054_spinal_hemorrhage0.89776341
111MP0008569_lethality_at_weaning0.88651569
112MP0002085_abnormal_embryonic_tissue0.88414905
113MP0008932_abnormal_embryonic_tissue0.88104822
114MP0000759_abnormal_skeletal_muscle0.87952406
115MP0004085_abnormal_heartbeat0.87693368
116MP0001849_ear_inflammation0.86301241
117MP0002972_abnormal_cardiac_muscle0.85517473
118MP0002233_abnormal_nose_morphology0.85500461
119MP0003828_pulmonary_edema0.85172344
120MP0002925_abnormal_cardiovascular_devel0.84546311
121MP0006072_abnormal_retinal_apoptosis0.83949968
122MP0000647_abnormal_sebaceous_gland0.83171846
123MP0000747_muscle_weakness0.82766668
124MP0005503_abnormal_tendon_morphology0.82611963
125MP0005501_abnormal_skin_physiology0.82535622
126MP0001501_abnormal_sleep_pattern0.82133887
127MP0001486_abnormal_startle_reflex0.81735038
128MP0001984_abnormal_olfaction0.81655872
129MP0000467_abnormal_esophagus_morphology0.81159058
130MP0003077_abnormal_cell_cycle0.80975195
131MP0008007_abnormal_cellular_replicative0.80264888
132MP0002822_catalepsy0.79771227
133MP0003091_abnormal_cell_migration0.79238735
134* MP0001697_abnormal_embryo_size0.79080800
135MP0005645_abnormal_hypothalamus_physiol0.78795667
136MP0000377_abnormal_hair_follicle0.78581618
137MP0000534_abnormal_ureter_morphology0.77757934
138MP0009703_decreased_birth_body0.77182056
139MP0005620_abnormal_muscle_contractility0.77075106
140MP0005621_abnormal_cell_physiology0.76967003
141MP0004782_abnormal_surfactant_physiolog0.76944577
142MP0005167_abnormal_blood-brain_barrier0.76349018
143MP0003385_abnormal_body_wall0.76201419
144MP0001879_abnormal_lymphatic_vessel0.75683730
145MP0005379_endocrine/exocrine_gland_phen0.74752276
146MP0004087_abnormal_muscle_fiber0.74751677
147MP0000428_abnormal_craniofacial_morphol0.74354925
148MP0003633_abnormal_nervous_system0.73099339
149MP0001188_hyperpigmentation0.73064619
150MP0002557_abnormal_social/conspecific_i0.72195615
151MP0003121_genomic_imprinting0.71035011
152MP0005248_abnormal_Harderian_gland0.71004481
153MP0002882_abnormal_neuron_morphology0.70838486
154MP0005171_absent_coat_pigmentation0.70758356
155MP0000778_abnormal_nervous_system0.70686016
156MP0004885_abnormal_endolymph0.70279487
157MP0009384_cardiac_valve_regurgitation0.69466562
158MP0001346_abnormal_lacrimal_gland0.68570063
159MP0002108_abnormal_muscle_morphology0.68442278
160MP0003935_abnormal_craniofacial_develop0.67452411

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)3.42998288
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.39881759
3Papilledema (HP:0001085)3.16984908
4Action tremor (HP:0002345)3.04288913
5Visual hallucinations (HP:0002367)2.98083514
6Protrusio acetabuli (HP:0003179)2.97944654
7Focal motor seizures (HP:0011153)2.80527851
8Insidious onset (HP:0003587)2.65185981
9Termporal pattern (HP:0011008)2.65185981
10Ankyloglossia (HP:0010296)2.61537294
11Aortic dissection (HP:0002647)2.54625566
12Cortical dysplasia (HP:0002539)2.49372402
13Resting tremor (HP:0002322)2.45766526
14Ventricular fibrillation (HP:0001663)2.43135168
15Atonic seizures (HP:0010819)2.41632158
16Focal seizures (HP:0007359)2.41375099
17Ulnar claw (HP:0001178)2.29763522
18Myokymia (HP:0002411)2.23158186
19Aortic aneurysm (HP:0004942)2.21968824
20Osteolytic defects of the phalanges of the hand (HP:0009771)2.21051650
21Osteolytic defects of the hand bones (HP:0009699)2.21051650
22Cerebral aneurysm (HP:0004944)2.20648682
23Abnormality of oral frenula (HP:0000190)2.20626472
24Overgrowth (HP:0001548)2.18212777
25Hyperinsulinemic hypoglycemia (HP:0000825)2.17366556
26Right ventricular cardiomyopathy (HP:0011663)2.16098475
27Macroorchidism (HP:0000053)2.14833232
28Abnormality of the left ventricular outflow tract (HP:0011103)2.12219072
29Subaortic stenosis (HP:0001682)2.12219072
30Abnormality of calcium-phosphate metabolism (HP:0100530)2.10108573
31Subacute progressive viral hepatitis (HP:0006572)2.09458633
32Hypercortisolism (HP:0001578)2.09378476
33Ankle clonus (HP:0011448)2.06441020
34Prolonged QT interval (HP:0001657)2.05396972
35Progressive cerebellar ataxia (HP:0002073)2.04780122
36Asymmetry of the thorax (HP:0001555)2.04427593
37Bundle branch block (HP:0011710)1.99583868
38Wormian bones (HP:0002645)1.99114572
39Ulnar bowing (HP:0003031)1.98898377
40Scapular winging (HP:0003691)1.98054829
41Absence seizures (HP:0002121)1.97690725
42Short nail (HP:0001799)1.97457019
43Abnormal pancreas size (HP:0012094)1.96946314
44Heterotopia (HP:0002282)1.94039028
45Increased nuchal translucency (HP:0010880)1.93649345
46Limb-girdle muscle atrophy (HP:0003797)1.91892429
47Vertebral arch anomaly (HP:0008438)1.91582667
48Depression (HP:0000716)1.91342895
49Cystic hygroma (HP:0000476)1.91274219
50Pheochromocytoma (HP:0002666)1.90522765
51Large earlobe (HP:0009748)1.88836183
52Scanning speech (HP:0002168)1.88800711
53Mitral stenosis (HP:0001718)1.88753794
54Hyporeflexia of lower limbs (HP:0002600)1.88608672
55Mildly elevated creatine phosphokinase (HP:0008180)1.87449825
56Pulmonic stenosis (HP:0001642)1.87423406
57Deviation of the thumb (HP:0009603)1.87362692
58Truncal ataxia (HP:0002078)1.87011632
59Mitral valve prolapse (HP:0001634)1.86607841
60Spinal rigidity (HP:0003306)1.86548053
61Buphthalmos (HP:0000557)1.86072419
62Hyperacusis (HP:0010780)1.85829110
63Agitation (HP:0000713)1.85025374
64Bladder diverticulum (HP:0000015)1.85020892
65Volvulus (HP:0002580)1.84743391
66Progressive sensorineural hearing impairment (HP:0000408)1.84719562
67Deep philtrum (HP:0002002)1.84385568
68Ankle contracture (HP:0006466)1.84345598
69Cubitus valgus (HP:0002967)1.83187330
70Megalencephaly (HP:0001355)1.83129155
71Generalized tonic-clonic seizures (HP:0002069)1.82931816
72Thoracolumbar scoliosis (HP:0002944)1.82676887
73Relative macrocephaly (HP:0004482)1.82161555
74Tetraparesis (HP:0002273)1.81566999
75Arterial tortuosity (HP:0005116)1.79512894
76Insomnia (HP:0100785)1.79444277
77Lower limb amyotrophy (HP:0007210)1.79128381
78Fragile skin (HP:0001030)1.78421974
79Hyperparathyroidism (HP:0000843)1.77723637
80Biliary tract neoplasm (HP:0100574)1.77552504
81Vertebral clefting (HP:0008428)1.77190258
82Limb-girdle muscle weakness (HP:0003325)1.77182943
83Abnormality of the distal phalanx of the thumb (HP:0009617)1.76608686
84Increased connective tissue (HP:0009025)1.76497284
85Abnormality of the ischium (HP:0003174)1.75469125
86Hypoplastic ischia (HP:0003175)1.75377906
87Broad face (HP:0000283)1.74225091
88Abnormality of the calcaneus (HP:0008364)1.73809472
89Absent frontal sinuses (HP:0002688)1.73296480
90Hypoplastic labia majora (HP:0000059)1.73272415
91Vascular tortuosity (HP:0004948)1.73137068
92Back pain (HP:0003418)1.73028296
93Papillary thyroid carcinoma (HP:0002895)1.72808317
94Congenital glaucoma (HP:0001087)1.72609105
95Neonatal short-limb short stature (HP:0008921)1.70822860
96Shoulder girdle muscle weakness (HP:0003547)1.69886763
97Flat acetabular roof (HP:0003180)1.69510318
98Capillary hemangiomas (HP:0005306)1.68603714
99Menstrual irregularities (HP:0000858)1.68300213
100Spinal cord lesions (HP:0100561)1.67288102
101Syringomyelia (HP:0003396)1.67288102
102Atrophic scars (HP:0001075)1.66895896
103Lower limb asymmetry (HP:0100559)1.66880933
104Unilateral renal agenesis (HP:0000122)1.66420220
105Leiomyosarcoma (HP:0100243)1.65195933
106Uterine leiomyosarcoma (HP:0002891)1.65195933
107Sudden death (HP:0001699)1.65158859
108Hyperglycemia (HP:0003074)1.64949336
109Aqueductal stenosis (HP:0002410)1.64490523
110Insulin-resistant diabetes mellitus (HP:0000831)1.64087814
111Hypoglycemic seizures (HP:0002173)1.63612748
112Open mouth (HP:0000194)1.63580195
113Overlapping toe (HP:0001845)1.63388514
114Abnormality of the labia majora (HP:0012881)1.63143022
115Upper limb amyotrophy (HP:0009129)1.63053973
116Distal upper limb amyotrophy (HP:0007149)1.63053973
117Proximal placement of thumb (HP:0009623)1.62662545
118Missing ribs (HP:0000921)1.62616131
119Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.62490256
120Hammertoe (HP:0001765)1.61952334
121Bladder carcinoma (HP:0002862)1.59524632
122Bladder neoplasm (HP:0009725)1.59524632
123Curly hair (HP:0002212)1.59284622
124Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.59104895
125Pelvic girdle muscle weakness (HP:0003749)1.58812823
126Deep palmar crease (HP:0006191)1.58458204
127Testicular neoplasm (HP:0010788)1.58385322
128Supranuclear gaze palsy (HP:0000605)1.57360470
129Dilatation of the ascending aorta (HP:0005111)1.56835793
130Urinary urgency (HP:0000012)1.56389509
131Mitral regurgitation (HP:0001653)1.56308385
132Febrile seizures (HP:0002373)1.55330375
133Bowel diverticulosis (HP:0005222)1.54707398
134Bronchomalacia (HP:0002780)1.54352472
135Exotropia (HP:0000577)1.54344594
136Soft skin (HP:0000977)1.54100130
137Abnormality of dentin (HP:0010299)1.53788176
138Pterygium (HP:0001059)1.53680939
139Pointed chin (HP:0000307)1.53453198
140Aneurysm (HP:0002617)1.53213435
141Thyroid carcinoma (HP:0002890)1.53011666
142Knee flexion contracture (HP:0006380)1.52907231
143Difficulty running (HP:0009046)1.52685092
144Impaired smooth pursuit (HP:0007772)1.52639554
145Dialeptic seizures (HP:0011146)1.52602077
146Shallow orbits (HP:0000586)1.52507362
147Syncope (HP:0001279)1.52132425
148Increased CSF protein (HP:0002922)1.52069291
149Enlarged penis (HP:0000040)1.51998016
150Arnold-Chiari malformation (HP:0002308)1.51727398
151Increased variability in muscle fiber diameter (HP:0003557)1.50995448
152Transitional cell carcinoma of the bladder (HP:0006740)1.50641925
153Germ cell neoplasia (HP:0100728)1.50035088
154Urinary bladder sphincter dysfunction (HP:0002839)1.50009413
155Bradycardia (HP:0001662)1.49889284
156Distal lower limb amyotrophy (HP:0008944)1.49836532
157Abnormality of the hip-girdle musculature (HP:0001445)1.49040751
158Abnormality of the musculature of the pelvis (HP:0001469)1.49040751
159Neuroendocrine neoplasm (HP:0100634)1.48910379
160Hyperextensible skin (HP:0000974)1.48182213
161Limited hip movement (HP:0008800)1.45914920
162Abnormality of pain sensation (HP:0010832)1.45884280
163Impaired pain sensation (HP:0007328)1.45884280
164Spastic diplegia (HP:0001264)1.45518357
165Protruding ear (HP:0000411)1.44574761
166Coronal craniosynostosis (HP:0004440)1.44546261
167Rhizomelia (HP:0008905)1.44121059

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.75419573
2FRK3.23721543
3MAP3K23.12311740
4MAP3K92.78866316
5NTRK12.76179935
6SCYL22.55815049
7PRKD32.46697180
8MST1R2.43950725
9PDGFRA2.33375588
10EPHA42.31219924
11FER2.25278187
12KSR22.23082887
13MINK12.12976780
14LMTK21.99801804
15LATS11.91746172
16WNK11.90923837
17TIE11.75323187
18NEK91.72666977
19DDR21.69862632
20RIPK41.68674269
21CDK121.66442524
22ICK1.61806444
23PAK31.61446325
24CAMKK11.60147241
25STK38L1.59460387
26TSSK61.59389863
27RIPK11.56509112
28PBK1.55792728
29BRD41.54017305
30SRPK11.53711615
31EPHB21.52426613
32RET1.48414253
33MAP3K41.47766872
34INSRR1.47488758
35CAMKK21.45061573
36TRIB31.35413497
37TTK1.31202822
38PAK61.30312384
39DMPK1.27662355
40HIPK21.26879089
41ERBB31.24613471
42PNCK1.23856321
43PLK21.23569041
44ERBB41.22980316
45CDC42BPA1.17717841
46MAP3K61.17321981
47TTN1.16968338
48PAK41.15303154
49PTK21.12707806
50STK31.11958804
51KSR11.11126155
52PAK21.07813858
53PDGFRB1.05888317
54EEF2K1.05772199
55CDK51.03815410
56WNK41.01398535
57UHMK11.00680854
58MAP2K10.97659976
59STK390.97538067
60PTK60.97047662
61PRKCH0.97007423
62MAP3K10.96677641
63LATS20.95190707
64NUAK10.94995578
65ALK0.94321332
66MOS0.92545637
67WEE10.92402705
68LIMK10.90582526
69FGFR30.87941059
70STK380.85232118
71EIF2AK10.84634053
72NEK20.84446071
73EIF2AK30.83270463
74MTOR0.80086266
75PRKCE0.79573965
76CASK0.77570697
77EPHA30.76376474
78KDR0.75121782
79STK240.74803966
80PASK0.74792523
81AKT30.72532937
82MAPKAPK30.70508021
83CAMK2D0.70411187
84MKNK10.69440252
85MET0.69092170
86CAMK1G0.68505039
87TYRO30.68504586
88SGK20.68141507
89CCNB10.67597083
90ARAF0.67340106
91DAPK20.66842283
92CAMK2B0.66234183
93ROCK10.65168920
94SGK30.64832978
95MKNK20.64328231
96MAP2K40.64029796
97CAMK1D0.63005098
98ROCK20.62808580
99AURKB0.62656246
100CSNK1A1L0.61352330
101YES10.61130864
102GRK50.60802553
103SGK10.60506005
104PRKD10.59807354
105MYLK0.59768508
106NEK10.59591516
107MAP2K70.59329164
108BUB10.58982541
109PKN20.57470712
110MAP3K120.55056310
111PIK3CA0.54887259
112FGFR10.54256778
113EPHA20.53917965
114CDK140.53677962
115TRIM280.53549007
116CDK180.53471140
117* MAPK100.52013368
118CAMK2A0.51675353
119BMPR20.50974754
120FGFR20.50219288
121MAP3K100.50183348
122PRKG20.49299654
123CDK80.49280007
124SGK4940.49084586
125SGK2230.49084586
126RPS6KA20.48829945
127STK110.48103451
128PLK10.47988086
129BCR0.47905100
130TESK10.47476195
131CDK150.47068057
132RPS6KA30.46316900
133RPS6KA40.45524146
134MARK10.43067898
135BRSK10.42455351
136TAF10.42293769
137PRKCG0.42161228
138NEK60.41965385
139WNK30.41618331
140TRPM70.41594456
141NTRK20.41036229
142CSNK1E0.40706560
143BRSK20.38995405
144CDK60.37556714
145PHKG20.37518857
146PHKG10.37518857
147PLK30.37158261
148DYRK1B0.36697964
149RAF10.36572359
150MAPK150.35592046

Predicted pathways (KEGG)

RankGene SetZ-score
1Insulin secretion_Homo sapiens_hsa049112.13881350
2Long-term potentiation_Homo sapiens_hsa047202.10862371
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08457184
4Olfactory transduction_Homo sapiens_hsa047401.77402352
5Amphetamine addiction_Homo sapiens_hsa050311.76203846
6Circadian entrainment_Homo sapiens_hsa047131.68125953
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64817717
8* Dopaminergic synapse_Homo sapiens_hsa047281.61556408
9Synaptic vesicle cycle_Homo sapiens_hsa047211.57351510
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55359097
11MicroRNAs in cancer_Homo sapiens_hsa052061.54750534
12Gastric acid secretion_Homo sapiens_hsa049711.54315479
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53087660
14Small cell lung cancer_Homo sapiens_hsa052221.50833298
15Type II diabetes mellitus_Homo sapiens_hsa049301.49057483
16Cholinergic synapse_Homo sapiens_hsa047251.48224246
17Pancreatic cancer_Homo sapiens_hsa052121.47934214
18Salivary secretion_Homo sapiens_hsa049701.42973699
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42770904
20Renin secretion_Homo sapiens_hsa049241.41611150
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.41236227
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38267185
23Taste transduction_Homo sapiens_hsa047421.37472987
24Estrogen signaling pathway_Homo sapiens_hsa049151.37396957
25GABAergic synapse_Homo sapiens_hsa047271.37114355
26Glutamatergic synapse_Homo sapiens_hsa047241.32786779
27Oxytocin signaling pathway_Homo sapiens_hsa049211.31178758
28Dorso-ventral axis formation_Homo sapiens_hsa043201.30725751
29Cocaine addiction_Homo sapiens_hsa050301.30339452
30Glioma_Homo sapiens_hsa052141.30210781
31GnRH signaling pathway_Homo sapiens_hsa049121.30161798
32Cell cycle_Homo sapiens_hsa041101.29905978
33Long-term depression_Homo sapiens_hsa047301.26783815
34Morphine addiction_Homo sapiens_hsa050321.26601591
35Colorectal cancer_Homo sapiens_hsa052101.25582784
36Dilated cardiomyopathy_Homo sapiens_hsa054141.25506762
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.25185529
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23305194
39Nicotine addiction_Homo sapiens_hsa050331.23009055
40Gap junction_Homo sapiens_hsa045401.21556320
41TGF-beta signaling pathway_Homo sapiens_hsa043501.20493845
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19978924
43Thyroid hormone synthesis_Homo sapiens_hsa049181.19770039
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18791105
45Pancreatic secretion_Homo sapiens_hsa049721.17863540
46Adherens junction_Homo sapiens_hsa045201.13853817
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.13840216
48Melanogenesis_Homo sapiens_hsa049161.13362148
49Vibrio cholerae infection_Homo sapiens_hsa051101.10852135
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10159318
51cAMP signaling pathway_Homo sapiens_hsa040241.09470408
52Serotonergic synapse_Homo sapiens_hsa047261.08023347
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07837774
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07588763
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.05535816
56mTOR signaling pathway_Homo sapiens_hsa041501.04750348
57AMPK signaling pathway_Homo sapiens_hsa041521.03563886
58Tight junction_Homo sapiens_hsa045301.02183769
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01975857
60Focal adhesion_Homo sapiens_hsa045101.01737146
61Fatty acid biosynthesis_Homo sapiens_hsa000610.99934279
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98198205
63Endometrial cancer_Homo sapiens_hsa052130.97915273
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95900030
65Oocyte meiosis_Homo sapiens_hsa041140.94547132
66Calcium signaling pathway_Homo sapiens_hsa040200.93926883
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.93741547
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93550491
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92866895
70PI3K-Akt signaling pathway_Homo sapiens_hsa041510.91753253
71Proteoglycans in cancer_Homo sapiens_hsa052050.91698597
72Pathways in cancer_Homo sapiens_hsa052000.90800084
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90322167
74mRNA surveillance pathway_Homo sapiens_hsa030150.89798619
75ErbB signaling pathway_Homo sapiens_hsa040120.89449302
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87258950
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87002525
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84554333
79Thyroid cancer_Homo sapiens_hsa052160.84363546
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83776929
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.83455971
82Rap1 signaling pathway_Homo sapiens_hsa040150.83059694
83VEGF signaling pathway_Homo sapiens_hsa043700.82341520
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.81702177
85Renal cell carcinoma_Homo sapiens_hsa052110.81175416
86Axon guidance_Homo sapiens_hsa043600.80716302
87Glucagon signaling pathway_Homo sapiens_hsa049220.80512161
88Basal cell carcinoma_Homo sapiens_hsa052170.79830125
89Hippo signaling pathway_Homo sapiens_hsa043900.79136891
90Type I diabetes mellitus_Homo sapiens_hsa049400.78617652
91ECM-receptor interaction_Homo sapiens_hsa045120.78083175
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77102702
93FoxO signaling pathway_Homo sapiens_hsa040680.76371959
94Non-homologous end-joining_Homo sapiens_hsa034500.76347565
95p53 signaling pathway_Homo sapiens_hsa041150.75879866
96Inositol phosphate metabolism_Homo sapiens_hsa005620.75139224
97Lysine degradation_Homo sapiens_hsa003100.74711988
98Alcoholism_Homo sapiens_hsa050340.73486920
99Amoebiasis_Homo sapiens_hsa051460.73466015
100Prolactin signaling pathway_Homo sapiens_hsa049170.73426827
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72863542
102Hedgehog signaling pathway_Homo sapiens_hsa043400.72618386
103Prostate cancer_Homo sapiens_hsa052150.71643874
104Choline metabolism in cancer_Homo sapiens_hsa052310.71322256
105Steroid biosynthesis_Homo sapiens_hsa001000.70885126
106Insulin signaling pathway_Homo sapiens_hsa049100.70238324
107Wnt signaling pathway_Homo sapiens_hsa043100.70139180
108Melanoma_Homo sapiens_hsa052180.69164792
109Shigellosis_Homo sapiens_hsa051310.69000759
110Prion diseases_Homo sapiens_hsa050200.68728477
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.68660720
112Bladder cancer_Homo sapiens_hsa052190.66916051
113Chronic myeloid leukemia_Homo sapiens_hsa052200.66735467
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66509987
115MAPK signaling pathway_Homo sapiens_hsa040100.66368111
116* Endocytosis_Homo sapiens_hsa041440.66365717
117RNA transport_Homo sapiens_hsa030130.66262786
118Mineral absorption_Homo sapiens_hsa049780.66140368
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65363108
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65085086
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65065789
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64224962
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63907294
124Ras signaling pathway_Homo sapiens_hsa040140.62734982
125Circadian rhythm_Homo sapiens_hsa047100.62568319
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62520358
127Insulin resistance_Homo sapiens_hsa049310.62276614
128Platelet activation_Homo sapiens_hsa046110.61773323
129Non-small cell lung cancer_Homo sapiens_hsa052230.61230041
130Protein digestion and absorption_Homo sapiens_hsa049740.61133269
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60772966
132Notch signaling pathway_Homo sapiens_hsa043300.58031421
133Sphingolipid metabolism_Homo sapiens_hsa006000.53976098
134HIF-1 signaling pathway_Homo sapiens_hsa040660.52557303
135Salmonella infection_Homo sapiens_hsa051320.52356624

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