KIF2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.31742052
2mitotic metaphase plate congression (GO:0007080)5.30844147
3mitotic sister chromatid segregation (GO:0000070)5.17552815
4protein localization to chromosome, centromeric region (GO:0071459)5.00563784
5DNA topological change (GO:0006265)4.92752369
6regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.85380718
7sister chromatid segregation (GO:0000819)4.81763618
8nuclear pore organization (GO:0006999)4.71407918
9metaphase plate congression (GO:0051310)4.71314719
10nuclear pore complex assembly (GO:0051292)4.56547718
11mitotic chromosome condensation (GO:0007076)4.52515910
12DNA replication-dependent nucleosome organization (GO:0034723)4.48065539
13DNA replication-dependent nucleosome assembly (GO:0006335)4.48065539
14regulation of spindle organization (GO:0090224)4.47055446
15mitotic nuclear envelope disassembly (GO:0007077)4.46596179
16kinetochore organization (GO:0051383)4.41200460
17DNA ligation (GO:0006266)4.41035187
18DNA unwinding involved in DNA replication (GO:0006268)4.37773842
19establishment of chromosome localization (GO:0051303)4.36929641
20DNA replication initiation (GO:0006270)4.18549318
21nuclear envelope disassembly (GO:0051081)4.15613373
22membrane disassembly (GO:0030397)4.15613373
23attachment of spindle microtubules to kinetochore (GO:0008608)4.15056737
24positive regulation of chromosome segregation (GO:0051984)4.14109043
25chromatin remodeling at centromere (GO:0031055)4.08917872
26DNA strand elongation involved in DNA replication (GO:0006271)4.05658437
27establishment of integrated proviral latency (GO:0075713)4.02909090
28CENP-A containing nucleosome assembly (GO:0034080)4.01514113
29regulation of mitotic spindle organization (GO:0060236)3.99588170
30kinetochore assembly (GO:0051382)3.95024255
31* regulation of chromosome segregation (GO:0051983)3.89975703
32positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.89203521
33positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.89203521
34positive regulation of mitotic sister chromatid separation (GO:1901970)3.89203521
35chromosome condensation (GO:0030261)3.87360522
36spindle checkpoint (GO:0031577)3.86684337
37meiotic chromosome segregation (GO:0045132)3.86366344
38DNA replication checkpoint (GO:0000076)3.84904499
39histone exchange (GO:0043486)3.84617501
40DNA strand elongation (GO:0022616)3.83849492
41negative regulation of chromosome segregation (GO:0051985)3.80678980
42DNA replication-independent nucleosome assembly (GO:0006336)3.79909587
43DNA replication-independent nucleosome organization (GO:0034724)3.79909587
44negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.74321262
45negative regulation of sister chromatid segregation (GO:0033046)3.74321262
46negative regulation of mitotic sister chromatid separation (GO:2000816)3.74321262
47negative regulation of mitotic sister chromatid segregation (GO:0033048)3.74321262
48mitotic sister chromatid cohesion (GO:0007064)3.73547858
49protein localization to chromosome (GO:0034502)3.72002056
50spindle assembly checkpoint (GO:0071173)3.68545662
51regulation of mitotic metaphase/anaphase transition (GO:0030071)3.67802307
52negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.67425218
53mitotic spindle checkpoint (GO:0071174)3.63992204
54mitotic spindle assembly checkpoint (GO:0007094)3.63705311
55telomere maintenance via semi-conservative replication (GO:0032201)3.62936007
56regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.62621704
57protein K6-linked ubiquitination (GO:0085020)3.57169423
58regulation of centrosome cycle (GO:0046605)3.54713798
59regulation of sister chromatid segregation (GO:0033045)3.54601709
60regulation of mitotic sister chromatid separation (GO:0010965)3.54601709
61regulation of mitotic sister chromatid segregation (GO:0033047)3.54601709
62DNA packaging (GO:0006323)3.52798642
63pore complex assembly (GO:0046931)3.50483340
64regulation of translational fidelity (GO:0006450)3.49781915
65* chromosome segregation (GO:0007059)3.48791406
66mitotic recombination (GO:0006312)3.45763700
67regulation of sister chromatid cohesion (GO:0007063)3.42873486
68telomere maintenance via recombination (GO:0000722)3.41454917
69regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.39475032
70regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39120346
71chromatin assembly or disassembly (GO:0006333)3.37959128
72nucleobase biosynthetic process (GO:0046112)3.33354885
73heterochromatin organization (GO:0070828)3.25763945
74DNA geometric change (GO:0032392)3.25555964
75DNA duplex unwinding (GO:0032508)3.25468057
76regulation of histone H3-K9 methylation (GO:0051570)3.25003171
77somatic diversification of immune receptors via somatic mutation (GO:0002566)3.23564566
78somatic hypermutation of immunoglobulin genes (GO:0016446)3.23564566
79regulation of centriole replication (GO:0046599)3.22989822
80nuclear envelope organization (GO:0006998)3.21228664
81DNA conformation change (GO:0071103)3.19388755
82ATP-dependent chromatin remodeling (GO:0043044)3.18745426
83folic acid-containing compound biosynthetic process (GO:0009396)3.18200660
84DNA synthesis involved in DNA repair (GO:0000731)3.17400922
85non-recombinational repair (GO:0000726)3.15296489
86double-strand break repair via nonhomologous end joining (GO:0006303)3.15296489
87telomere maintenance via telomere lengthening (GO:0010833)3.11797679
88protein complex localization (GO:0031503)3.11757205
89purine nucleobase biosynthetic process (GO:0009113)3.10556776
90spindle organization (GO:0007051)3.09399973
91formation of translation preinitiation complex (GO:0001731)3.08989658
92maturation of SSU-rRNA (GO:0030490)3.07778738
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.07284940
94IMP biosynthetic process (GO:0006188)3.06285827
95establishment of viral latency (GO:0019043)3.04058871
96establishment of mitotic spindle localization (GO:0040001)3.01881864
97nucleotide-excision repair, DNA gap filling (GO:0006297)3.01373022
98* microtubule depolymerization (GO:0007019)3.00238277
99mitotic cytokinesis (GO:0000281)2.99937539
100spindle assembly involved in mitosis (GO:0090307)2.95805595
101mitotic spindle organization (GO:0007052)2.95337080
102ribosome assembly (GO:0042255)2.93701887
103* mitotic cell cycle (GO:0000278)2.93539233
104chromosome organization (GO:0051276)2.93524155
105mitotic G2/M transition checkpoint (GO:0044818)2.93359237
106mismatch repair (GO:0006298)2.92628292
107chromatin assembly (GO:0031497)2.90822401
108regulation of gene silencing by RNA (GO:0060966)2.88539323
109regulation of posttranscriptional gene silencing (GO:0060147)2.88539323
110regulation of gene silencing by miRNA (GO:0060964)2.88539323
111negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.88425484
112negative regulation of mitosis (GO:0045839)2.86300667
113negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.85389591
114regulation of telomere maintenance via telomerase (GO:0032210)2.83367765
115regulation of spindle checkpoint (GO:0090231)2.82935290
116negative regulation of histone methylation (GO:0031061)2.82337057
117spliceosomal snRNP assembly (GO:0000387)2.81657373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.75466696
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.58631091
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.41201689
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.10611883
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.04102147
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.84023258
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95136715
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.83784836
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62086109
10AR_21909140_ChIP-Seq_LNCAP_Human2.58887484
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43315331
12* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.40556340
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.35332764
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29113119
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.26415074
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22806083
17* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.22323516
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.18600281
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.17161650
20XRN2_22483619_ChIP-Seq_HELA_Human2.16529920
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09489158
22* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01870563
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.01420209
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93103788
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.92101517
26NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85597343
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85091772
28* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82991752
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77668113
30VDR_23849224_ChIP-Seq_CD4+_Human1.77427283
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.66954359
32FOXP3_21729870_ChIP-Seq_TREG_Human1.66249327
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65483933
34TTF2_22483619_ChIP-Seq_HELA_Human1.62135704
35DCP1A_22483619_ChIP-Seq_HELA_Human1.59332841
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54814913
37GABP_19822575_ChIP-Seq_HepG2_Human1.53961666
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50345590
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.49237022
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44499789
41SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44139882
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43692623
43KDM5A_27292631_Chip-Seq_BREAST_Human1.42999217
44MYC_22102868_ChIP-Seq_BL_Human1.39119917
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.37170410
46* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36385210
47ELK1_19687146_ChIP-ChIP_HELA_Human1.35713508
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35623329
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35379642
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34792365
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34235832
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32270378
53* CIITA_25753668_ChIP-Seq_RAJI_Human1.32177655
54* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31820252
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26139925
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23578780
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23499811
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.22026205
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19410228
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17882691
61* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15321788
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14646719
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13498283
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12844796
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11956335
66NANOG_21062744_ChIP-ChIP_HESCs_Human1.11814717
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10419363
68* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09998916
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09728743
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09375996
71ZNF263_19887448_ChIP-Seq_K562_Human1.08235625
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06386063
73* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06262927
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05785636
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05727887
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05084466
77* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04675420
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04603452
79KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01364602
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01364602
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01364602
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00424631
83TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98279265
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97773223
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97214667
86ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94949159
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94367236
88TFEB_21752829_ChIP-Seq_HELA_Human0.93315352
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92154556
90SOX17_20123909_ChIP-Seq_XEN_Mouse0.92033075
91* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90305803
92MYC_18940864_ChIP-ChIP_HL60_Human0.87462946
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87117610
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86484001
95TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85844901
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85835526
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84879121
98CHD1_26751641_Chip-Seq_LNCaP_Human0.84717634
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83343929
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82604236
101* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82191482
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81537491
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81006006
104NCOR1_26117541_ChIP-Seq_K562_Human0.80788772
105ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79144035
106* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.76407200
107SRF_21415370_ChIP-Seq_HL-1_Mouse0.76208447
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75753486
109* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74495546
110ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.73784108
111NANOG_16153702_ChIP-ChIP_HESCs_Human0.72927691
112* SOX2_16153702_ChIP-ChIP_HESCs_Human0.72783487
113* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71971780
114* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.71936180
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.71371217
116TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71132193
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.68536783

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.28108705
2MP0003111_abnormal_nucleus_morphology4.90541652
3MP0010094_abnormal_chromosome_stability4.70524864
4MP0004957_abnormal_blastocyst_morpholog4.14922725
5MP0003077_abnormal_cell_cycle4.13506344
6MP0008057_abnormal_DNA_replication3.82039392
7MP0008058_abnormal_DNA_repair3.12278155
8MP0008877_abnormal_DNA_methylation2.82086764
9MP0008007_abnormal_cellular_replicative2.76192822
10MP0008932_abnormal_embryonic_tissue2.66155865
11MP0003123_paternal_imprinting2.54005629
12MP0001730_embryonic_growth_arrest2.49100393
13MP0000350_abnormal_cell_proliferation2.27189958
14MP0010307_abnormal_tumor_latency2.21246228
15MP0005410_abnormal_fertilization2.03991057
16MP0009697_abnormal_copulation2.01961413
17MP0010352_gastrointestinal_tract_polyps2.00393005
18MP0005380_embryogenesis_phenotype1.93059266
19MP0001672_abnormal_embryogenesis/_devel1.93059266
20MP0001929_abnormal_gametogenesis1.85760383
21MP0001697_abnormal_embryo_size1.84631402
22MP0003786_premature_aging1.84176316
23MP0002210_abnormal_sex_determination1.81964052
24MP0002085_abnormal_embryonic_tissue1.78964357
25MP0005076_abnormal_cell_differentiation1.75986360
26MP0003718_maternal_effect1.74246289
27MP0002084_abnormal_developmental_patter1.72144441
28MP0002877_abnormal_melanocyte_morpholog1.71594920
29MP0003984_embryonic_growth_retardation1.67214362
30MP0002088_abnormal_embryonic_growth/wei1.63087914
31MP0002080_prenatal_lethality1.61479967
32MP0003121_genomic_imprinting1.60357159
33MP0010030_abnormal_orbit_morphology1.59565795
34MP0002653_abnormal_ependyma_morphology1.56306399
35MP0001145_abnormal_male_reproductive1.54396024
36MP0002396_abnormal_hematopoietic_system1.52294344
37MP0004197_abnormal_fetal_growth/weight/1.51386170
38MP0002086_abnormal_extraembryonic_tissu1.50068161
39MP0003890_abnormal_embryonic-extraembry1.41110891
40MP0003698_abnormal_male_reproductive1.37950259
41MP0000653_abnormal_sex_gland1.36366869
42MP0000313_abnormal_cell_death1.35372677
43MP0001293_anophthalmia1.29200355
44MP0000537_abnormal_urethra_morphology1.28819348
45MP0009053_abnormal_anal_canal1.28757236
46MP0004808_abnormal_hematopoietic_stem1.27359312
47MP0000490_abnormal_crypts_of1.25577909
48MP0002019_abnormal_tumor_incidence1.24495047
49MP0003937_abnormal_limbs/digits/tail_de1.24144037
50MP0000566_synostosis1.14911777
51MP0003567_abnormal_fetal_cardiomyocyte1.14790376
52MP0003315_abnormal_perineum_morphology1.11695379
53MP0003705_abnormal_hypodermis_morpholog1.11524773
54MP0003119_abnormal_digestive_system1.07020745
55MP0003941_abnormal_skin_development1.06533502
56MP0002938_white_spotting1.06105492
57MP0004133_heterotaxia1.01819112
58MP0002161_abnormal_fertility/fecundity1.01813825
59MP0001346_abnormal_lacrimal_gland1.00383805
60MP0002160_abnormal_reproductive_system0.98247838
61MP0006035_abnormal_mitochondrial_morpho0.97985079
62MP0009278_abnormal_bone_marrow0.97978758
63MP0004185_abnormal_adipocyte_glucose0.97790173
64MP0001119_abnormal_female_reproductive0.94962616
65MP0002111_abnormal_tail_morphology0.91440247
66MP0005397_hematopoietic_system_phenotyp0.90894072
67MP0001545_abnormal_hematopoietic_system0.90894072
68MP0001849_ear_inflammation0.90212170
69MP0001661_extended_life_span0.89989032
70MP0008995_early_reproductive_senescence0.89965099
71MP0003950_abnormal_plasma_membrane0.86157111
72MP0009672_abnormal_birth_weight0.86124827
73MP0001915_intracranial_hemorrhage0.85058366
74MP0006292_abnormal_olfactory_placode0.84686271
75MP0000678_abnormal_parathyroid_gland0.83823091
76MP0005501_abnormal_skin_physiology0.83299139
77MP0003385_abnormal_body_wall0.83020849
78MP0004147_increased_porphyrin_level0.82724338
79MP0000428_abnormal_craniofacial_morphol0.81812569
80MP0005389_reproductive_system_phenotype0.81724776
81MP0000703_abnormal_thymus_morphology0.81617513
82MP0000432_abnormal_head_morphology0.80453970
83MP0005451_abnormal_body_composition0.80314284
84MP0003115_abnormal_respiratory_system0.79227085
85MP0002092_abnormal_eye_morphology0.78696555
86MP0009703_decreased_birth_body0.77914516
87MP0005384_cellular_phenotype0.77762490
88MP0005621_abnormal_cell_physiology0.77187790
89MP0002009_preneoplasia0.75986713
90MP0010234_abnormal_vibrissa_follicle0.73889246
91MP0005023_abnormal_wound_healing0.73855431
92MP0000733_abnormal_muscle_development0.73759709
93MP0008789_abnormal_olfactory_epithelium0.73440450
94MP0002282_abnormal_trachea_morphology0.73286724
95MP0005408_hypopigmentation0.72786697
96MP0003566_abnormal_cell_adhesion0.71937340
97MP0003935_abnormal_craniofacial_develop0.71733597
98MP0003861_abnormal_nervous_system0.71539898
99MP0000358_abnormal_cell_content/0.70912014
100MP0002234_abnormal_pharynx_morphology0.70789566
101MP0002233_abnormal_nose_morphology0.70044763
102MP0001286_abnormal_eye_development0.69836508
103MP0004233_abnormal_muscle_weight0.69172711
104MP0002697_abnormal_eye_size0.68454518
105MP0000858_altered_metastatic_potential0.68238077
106MP0003699_abnormal_female_reproductive0.67695942
107MP0005171_absent_coat_pigmentation0.67031891
108MP0002932_abnormal_joint_morphology0.66261768
109MP0003221_abnormal_cardiomyocyte_apopto0.66166470
110MP0003942_abnormal_urinary_system0.65909078
111MP0003755_abnormal_palate_morphology0.65884736
112MP0009333_abnormal_splenocyte_physiolog0.65841361
113MP0009379_abnormal_foot_pigmentation0.65498383
114MP0005499_abnormal_olfactory_system0.65180056
115MP0005394_taste/olfaction_phenotype0.65180056
116MP0005395_other_phenotype0.64935841
117MP0001727_abnormal_embryo_implantation0.64744465
118MP0006054_spinal_hemorrhage0.63330658
119MP0002269_muscular_atrophy0.62940519
120MP0003136_yellow_coat_color0.61646777
121MP0005623_abnormal_meninges_morphology0.61497612
122MP0000049_abnormal_middle_ear0.60478161
123MP0004264_abnormal_extraembryonic_tissu0.60172090
124MP0002102_abnormal_ear_morphology0.59796652
125MP0001881_abnormal_mammary_gland0.59511506
126MP0002925_abnormal_cardiovascular_devel0.59477683
127MP0000372_irregular_coat_pigmentation0.58841074
128MP0002249_abnormal_larynx_morphology0.58762550
129MP0002722_abnormal_immune_system0.58658108
130MP0002114_abnormal_axial_skeleton0.58373807
131MP0003186_abnormal_redox_activity0.58112644
132MP0002398_abnormal_bone_marrow0.57075555
133MP0001919_abnormal_reproductive_system0.56393338
134MP0003806_abnormal_nucleotide_metabolis0.55044544

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.53838356
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.47011673
3Birth length less than 3rd percentile (HP:0003561)3.79324643
4Medulloblastoma (HP:0002885)3.77469344
5Cortical dysplasia (HP:0002539)3.58892801
6Meckel diverticulum (HP:0002245)3.50777524
7Abnormality of chromosome stability (HP:0003220)3.48159498
8Impulsivity (HP:0100710)3.43822451
9Ependymoma (HP:0002888)3.39287194
10Patellar aplasia (HP:0006443)3.35710078
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.35120764
12Abnormality of the ileum (HP:0001549)3.33092070
13Breast hypoplasia (HP:0003187)3.31968444
14Selective tooth agenesis (HP:0001592)3.24913870
15Abnormality of the preputium (HP:0100587)3.22443073
16Aplasia/Hypoplasia of the patella (HP:0006498)3.15559791
17Small intestinal stenosis (HP:0012848)3.13978015
18Duodenal stenosis (HP:0100867)3.13978015
19Abnormal gallbladder physiology (HP:0012438)3.07270727
20Cholecystitis (HP:0001082)3.07270727
21Colon cancer (HP:0003003)3.04231558
22Reticulocytopenia (HP:0001896)3.04035765
23Aplasia/Hypoplasia of the sacrum (HP:0008517)3.02393710
24Carpal bone hypoplasia (HP:0001498)3.01439041
25Abnormality of the labia minora (HP:0012880)2.93433040
26Absent radius (HP:0003974)2.87232902
27Ectopic kidney (HP:0000086)2.78179860
28Supernumerary spleens (HP:0009799)2.77054716
29Abnormal lung lobation (HP:0002101)2.74763011
30Myelodysplasia (HP:0002863)2.72130203
31Increased nuchal translucency (HP:0010880)2.71705088
32Rhabdomyosarcoma (HP:0002859)2.67755922
33Aplasia involving forearm bones (HP:0009822)2.67732562
34Absent forearm bone (HP:0003953)2.67732562
35Sloping forehead (HP:0000340)2.67435665
36Agnosia (HP:0010524)2.66359185
37Absent thumb (HP:0009777)2.62654483
38Abnormality of reticulocytes (HP:0004312)2.58893943
39Abnormality of the duodenum (HP:0002246)2.57935334
40Degeneration of anterior horn cells (HP:0002398)2.55895372
41Abnormality of the anterior horn cell (HP:0006802)2.55895372
42Nephroblastoma (Wilms tumor) (HP:0002667)2.55584727
43Abnormality of cochlea (HP:0000375)2.47730656
44Hypoplasia of the capital femoral epiphysis (HP:0003090)2.45584471
45Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.45168855
46Short 4th metacarpal (HP:0010044)2.45168855
47Abnormality of glycolysis (HP:0004366)2.42316326
48Embryonal renal neoplasm (HP:0011794)2.40028211
49Oral leukoplakia (HP:0002745)2.38803870
50Abnormality of the carotid arteries (HP:0005344)2.38004448
51Abnormality of the astrocytes (HP:0100707)2.35931738
52Astrocytoma (HP:0009592)2.35931738
53Overlapping toe (HP:0001845)2.32933778
5411 pairs of ribs (HP:0000878)2.30203794
55Proximal placement of thumb (HP:0009623)2.28067310
56Deviation of the thumb (HP:0009603)2.27569390
57Neoplasm of the pancreas (HP:0002894)2.27492759
58Short thumb (HP:0009778)2.26915064
59Aplasia/Hypoplasia of the sternum (HP:0006714)2.24844003
60Cafe-au-lait spot (HP:0000957)2.24761319
61Abnormality of abdominal situs (HP:0011620)2.24431229
62Abdominal situs inversus (HP:0003363)2.24431229
63High anterior hairline (HP:0009890)2.23289517
64Duplication of thumb phalanx (HP:0009942)2.22682835
65Volvulus (HP:0002580)2.22181795
66Broad distal phalanx of finger (HP:0009836)2.21027761
67Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.20708560
68Missing ribs (HP:0000921)2.18580184
69Neoplasm of the oral cavity (HP:0100649)2.18529885
70Bone marrow hypocellularity (HP:0005528)2.18022842
71Tracheoesophageal fistula (HP:0002575)2.17163739
72High pitched voice (HP:0001620)2.16459570
73Glioma (HP:0009733)2.15898642
74Atresia of the external auditory canal (HP:0000413)2.14916034
75Neoplasm of striated muscle (HP:0009728)2.14609099
76Duplicated collecting system (HP:0000081)2.13805818
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.12821578
78Facial hemangioma (HP:0000329)2.12737644
79Microvesicular hepatic steatosis (HP:0001414)2.12529060
80Choanal atresia (HP:0000453)2.10966548
81Rough bone trabeculation (HP:0100670)2.10054871
82Aplasia/hypoplasia of the humerus (HP:0006507)2.09194514
83Progressive muscle weakness (HP:0003323)2.09132566
84Triphalangeal thumb (HP:0001199)2.07714131
85Increased serum pyruvate (HP:0003542)2.06914552
86Multiple enchondromatosis (HP:0005701)2.06551907
87Arteriovenous malformation (HP:0100026)2.06452368
88Progressive external ophthalmoplegia (HP:0000590)2.05645731
89Basal cell carcinoma (HP:0002671)2.05533560
90Embryonal neoplasm (HP:0002898)2.04343468
91Reticulocytosis (HP:0001923)2.03408545
92Horseshoe kidney (HP:0000085)2.02944746
93Abnormal number of erythroid precursors (HP:0012131)1.99258381
94Ankyloglossia (HP:0010296)1.98490158
95Biliary tract neoplasm (HP:0100574)1.98229159
96Aplastic anemia (HP:0001915)1.97971987
97Abnormality of chromosome segregation (HP:0002916)1.97860766
98Deep philtrum (HP:0002002)1.96669287
99Abnormal number of incisors (HP:0011064)1.95763060
100Clubbing of toes (HP:0100760)1.95505093
101Hypoplastic pelvis (HP:0008839)1.92603654
102Abnormal spermatogenesis (HP:0008669)1.91350474
103Neoplasm of the colon (HP:0100273)1.90865356
104Squamous cell carcinoma (HP:0002860)1.90186502
105Pallor (HP:0000980)1.89457582
106Insomnia (HP:0100785)1.88377100
107Premature ovarian failure (HP:0008209)1.87846888
108Short humerus (HP:0005792)1.85438338
109Morphological abnormality of the inner ear (HP:0011390)1.83141580
110Abnormality of the renal collecting system (HP:0004742)1.82983257
111Poikiloderma (HP:0001029)1.79683245
112Prominent nose (HP:0000448)1.79245003
113Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79169281
114Absent epiphyses (HP:0010577)1.79169281
115Macrocytic anemia (HP:0001972)1.78216561
116Cerebral hypomyelination (HP:0006808)1.78121957
117Abnormality of cells of the erythroid lineage (HP:0012130)1.78120600
118Ovarian neoplasm (HP:0100615)1.77176794
119Abnormality of DNA repair (HP:0003254)1.76643450
120Oligodactyly (HP:0012165)1.75333729
121Facial cleft (HP:0002006)1.74837753
122Cleft eyelid (HP:0000625)1.74600005
123Premature graying of hair (HP:0002216)1.73837583
124Gastrointestinal carcinoma (HP:0002672)1.71088508
125Malignant gastrointestinal tract tumors (HP:0006749)1.71088508
126Aplasia/Hypoplasia of the earlobes (HP:0009906)1.70972305
127Rib fusion (HP:0000902)1.70301804
128Microglossia (HP:0000171)1.70121936
129Esophageal atresia (HP:0002032)1.68955983
130Abnormality of the 4th metacarpal (HP:0010012)1.68794756
131Abnormality of the calcaneus (HP:0008364)1.67615041
132Entropion (HP:0000621)1.67139971
133Secondary amenorrhea (HP:0000869)1.65696032
134Orthostatic hypotension (HP:0001278)1.62953597
135Sandal gap (HP:0001852)1.62900440
136Ureteral duplication (HP:0000073)1.62397379
137Small epiphyses (HP:0010585)1.62092676
138Abnormality of the umbilical cord (HP:0010881)1.59774775

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.20140673
2CDC74.34452048
3WEE14.01457663
4NEK23.77971772
5TTK3.24705542
6NEK12.67174141
7CDK122.45617165
8BRSK22.39738701
9PLK12.36500520
10PLK42.22872275
11EEF2K2.14935151
12SRPK12.12570752
13EIF2AK12.07043666
14CHEK21.81474229
15* AURKB1.79416753
16BRSK11.78920175
17PLK31.78476870
18STK101.77487939
19ACVR1B1.76927723
20TSSK61.76600253
21VRK21.73623078
22ATR1.71943008
23PDK41.69143559
24PDK31.69143559
25TESK21.64007015
26SMG11.63821086
27PASK1.62945187
28CDK71.60440165
29MKNK11.60312003
30RPS6KB21.54169378
31TESK11.54127162
32MAP3K81.50827689
33AURKA1.45574924
34CHEK11.45024943
35CDK41.43284137
36TLK11.41251780
37EPHA21.28353301
38DYRK31.26770580
39RPS6KA41.25970114
40MKNK21.25365708
41MAP3K101.21810808
42STK41.21739013
43STK31.21226226
44VRK11.10120659
45PAK41.09975122
46MELK1.09531552
47BRD41.06875244
48CCNB11.06511193
49ATM1.06000121
50STK38L1.00757601
51CDK20.93332661
52ZAK0.92278800
53PDK20.91323071
54EIF2AK30.90591962
55MST1R0.89751305
56TGFBR10.85014492
57STK160.83195911
58LATS20.82789835
59CDK60.82703926
60TAF10.81940100
61LATS10.80158576
62* CDK10.77187009
63NME10.76594432
64PNCK0.71320730
65KSR20.69426746
66PIM10.68741326
67TRIB30.68660403
68ALK0.67382565
69PBK0.66357496
70PKN20.66068817
71ICK0.64391379
72BRAF0.63154974
73* PAK10.62357327
74MTOR0.62046078
75IRAK30.61010747
76RAF10.60197545
77CDK80.57418098
78MET0.55261355
79SCYL20.54407280
80NME20.53150885
81CSNK2A20.52102120
82CSNK2A10.51806500
83EIF2AK20.49185631
84MST40.48647334
85PRKCI0.47482423
86KSR10.43562074
87CLK10.40987696
88CDK140.40865394
89BMX0.40389915
90RPS6KA50.39185224
91ERBB40.38850691
92MARK30.38539730
93MAPKAPK30.38165976
94PRKDC0.37562243
95LRRK20.37321805
96AKT20.37033444
97CSNK1E0.34712252
98PRKD30.34037787
99TTN0.33358763
100TRIM280.31347581
101MAP3K90.31173517
102CSNK1D0.30805092
103PAK20.30460478
104FLT30.29419870
105MAPK140.27818640
106CDK90.27560940
107AKT30.27094063
108AKT10.24224023
109RPS6KA10.23335744
110ARAF0.23246120
111GSK3B0.20886047
112FGFR10.19041771
113MAPK10.19012589
114CDK11A0.18548533
115CDK150.17906408
116DYRK1B0.17366106
117PDGFRA0.16641539
118MAPK110.16450007
119CDK180.15509293

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.75197629
2Mismatch repair_Homo sapiens_hsa034304.25860972
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55570682
4Cell cycle_Homo sapiens_hsa041103.45484615
5RNA transport_Homo sapiens_hsa030133.42805102
6Spliceosome_Homo sapiens_hsa030403.34095675
7Homologous recombination_Homo sapiens_hsa034403.19082427
8Base excision repair_Homo sapiens_hsa034103.02738637
9Nucleotide excision repair_Homo sapiens_hsa034202.90736508
10Fanconi anemia pathway_Homo sapiens_hsa034602.81849127
11One carbon pool by folate_Homo sapiens_hsa006702.64946559
12RNA polymerase_Homo sapiens_hsa030202.55683513
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.48908595
14Proteasome_Homo sapiens_hsa030502.31511192
15Basal transcription factors_Homo sapiens_hsa030222.30795265
16Non-homologous end-joining_Homo sapiens_hsa034502.20526256
17Ribosome_Homo sapiens_hsa030102.17263805
18mRNA surveillance pathway_Homo sapiens_hsa030152.15491070
19Pyrimidine metabolism_Homo sapiens_hsa002402.04894293
20RNA degradation_Homo sapiens_hsa030182.01580310
21p53 signaling pathway_Homo sapiens_hsa041151.82772714
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77754009
23Systemic lupus erythematosus_Homo sapiens_hsa053221.66167015
24Oocyte meiosis_Homo sapiens_hsa041141.62690725
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.51722312
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43325295
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40261714
28Vitamin B6 metabolism_Homo sapiens_hsa007501.23836984
29Viral carcinogenesis_Homo sapiens_hsa052031.22298914
30Epstein-Barr virus infection_Homo sapiens_hsa051691.21283961
31Pyruvate metabolism_Homo sapiens_hsa006201.21185012
32Purine metabolism_Homo sapiens_hsa002301.15612131
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02912392
34MicroRNAs in cancer_Homo sapiens_hsa052061.00168655
35HTLV-I infection_Homo sapiens_hsa051660.93322837
36Herpes simplex infection_Homo sapiens_hsa051680.92202984
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92151854
38Antigen processing and presentation_Homo sapiens_hsa046120.90853101
39Selenocompound metabolism_Homo sapiens_hsa004500.87693160
40Sulfur relay system_Homo sapiens_hsa041220.86710898
41Biosynthesis of amino acids_Homo sapiens_hsa012300.86689767
42Basal cell carcinoma_Homo sapiens_hsa052170.82484105
43Steroid biosynthesis_Homo sapiens_hsa001000.81076220
44Pentose phosphate pathway_Homo sapiens_hsa000300.78866569
45Hippo signaling pathway_Homo sapiens_hsa043900.78311448
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77536514
47Small cell lung cancer_Homo sapiens_hsa052220.75705831
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.70594406
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70541526
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69208915
51Alcoholism_Homo sapiens_hsa050340.67771930
52Hedgehog signaling pathway_Homo sapiens_hsa043400.66029862
53TGF-beta signaling pathway_Homo sapiens_hsa043500.65797083
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65236678
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60146225
56Notch signaling pathway_Homo sapiens_hsa043300.59843436
57Fatty acid elongation_Homo sapiens_hsa000620.59052854
58Colorectal cancer_Homo sapiens_hsa052100.57833842
59Protein export_Homo sapiens_hsa030600.54344203
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54178673
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.53370384
62Thyroid cancer_Homo sapiens_hsa052160.52951973
63Adherens junction_Homo sapiens_hsa045200.51495744
64Legionellosis_Homo sapiens_hsa051340.50037355
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49774043
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49726478
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48297213
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45825466
69Apoptosis_Homo sapiens_hsa042100.42694275
70Parkinsons disease_Homo sapiens_hsa050120.41010146
71Carbon metabolism_Homo sapiens_hsa012000.40881043
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.40125196
73Bladder cancer_Homo sapiens_hsa052190.39964883
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37710999
75mTOR signaling pathway_Homo sapiens_hsa041500.37168079
76Chronic myeloid leukemia_Homo sapiens_hsa052200.36922583
77Pathways in cancer_Homo sapiens_hsa052000.35899769
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35570689
79Glutathione metabolism_Homo sapiens_hsa004800.35479135
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.35163084
81Arginine biosynthesis_Homo sapiens_hsa002200.34800384
82HIF-1 signaling pathway_Homo sapiens_hsa040660.34428056
83Hepatitis B_Homo sapiens_hsa051610.33641643
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31978490
85Propanoate metabolism_Homo sapiens_hsa006400.31731438
86Lysine degradation_Homo sapiens_hsa003100.30535063
87Fructose and mannose metabolism_Homo sapiens_hsa000510.30066319
88Tight junction_Homo sapiens_hsa045300.28951242
89Shigellosis_Homo sapiens_hsa051310.28494144
90Wnt signaling pathway_Homo sapiens_hsa043100.28373785
91Prostate cancer_Homo sapiens_hsa052150.27380966
92Metabolic pathways_Homo sapiens_hsa011000.27181731
93Influenza A_Homo sapiens_hsa051640.24425522
94Viral myocarditis_Homo sapiens_hsa054160.23974266
95Folate biosynthesis_Homo sapiens_hsa007900.23684934
96Glioma_Homo sapiens_hsa052140.22934572
97Arginine and proline metabolism_Homo sapiens_hsa003300.22254657
98FoxO signaling pathway_Homo sapiens_hsa040680.22104366
99Measles_Homo sapiens_hsa051620.21886412
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21705763
101Fatty acid metabolism_Homo sapiens_hsa012120.21322085
102Acute myeloid leukemia_Homo sapiens_hsa052210.21035526
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20758205
104Proteoglycans in cancer_Homo sapiens_hsa052050.20288943
105Melanoma_Homo sapiens_hsa052180.17621627
106Pancreatic cancer_Homo sapiens_hsa052120.15914611
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.15718193
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15037598
109Non-small cell lung cancer_Homo sapiens_hsa052230.14253690
110Renin-angiotensin system_Homo sapiens_hsa046140.14221850
111Oxidative phosphorylation_Homo sapiens_hsa001900.13935187
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.12717227
113Primary immunodeficiency_Homo sapiens_hsa053400.12639695
114Huntingtons disease_Homo sapiens_hsa050160.12300500
115Endometrial cancer_Homo sapiens_hsa052130.11971849
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10370516
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09452993
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09441541
119Linoleic acid metabolism_Homo sapiens_hsa005910.08520612
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.07400508
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.06319801
122N-Glycan biosynthesis_Homo sapiens_hsa005100.05539396
123Galactose metabolism_Homo sapiens_hsa000520.05417751

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