KIF23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.31082398
2mitotic metaphase plate congression (GO:0007080)6.14377261
3mitotic chromosome condensation (GO:0007076)5.53884511
4protein localization to chromosome, centromeric region (GO:0071459)5.50722484
5metaphase plate congression (GO:0051310)5.44243283
6attachment of spindle microtubules to kinetochore (GO:0008608)5.40059647
7mitotic sister chromatid segregation (GO:0000070)5.29159102
8kinetochore organization (GO:0051383)5.27482804
9regulation of spindle organization (GO:0090224)5.24604719
10regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.07297196
11sister chromatid segregation (GO:0000819)4.96638390
12establishment of chromosome localization (GO:0051303)4.92200221
13regulation of mitotic spindle organization (GO:0060236)4.79527587
14CENP-A containing nucleosome assembly (GO:0034080)4.73664013
15kinetochore assembly (GO:0051382)4.65051059
16chromatin remodeling at centromere (GO:0031055)4.63265401
17mitotic nuclear envelope disassembly (GO:0007077)4.55936244
18DNA ligation (GO:0006266)4.53722071
19positive regulation of chromosome segregation (GO:0051984)4.41938293
20nuclear pore organization (GO:0006999)4.38608687
21nuclear pore complex assembly (GO:0051292)4.35462537
22DNA replication-independent nucleosome organization (GO:0034724)4.34913253
23DNA replication-independent nucleosome assembly (GO:0006336)4.34913253
24DNA replication checkpoint (GO:0000076)4.26953969
25meiotic chromosome segregation (GO:0045132)4.25676386
26spindle checkpoint (GO:0031577)4.24913971
27membrane disassembly (GO:0030397)4.24628043
28nuclear envelope disassembly (GO:0051081)4.24628043
29protein localization to chromosome (GO:0034502)4.23217943
30regulation of chromosome segregation (GO:0051983)4.10448720
31positive regulation of mitotic sister chromatid separation (GO:1901970)4.08319148
32positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.08319148
33positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.08319148
34establishment of integrated proviral latency (GO:0075713)4.07084692
35histone exchange (GO:0043486)4.07052885
36DNA unwinding involved in DNA replication (GO:0006268)4.04955627
37regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.97815010
38negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.96290686
39chromosome segregation (GO:0007059)3.93490301
40DNA replication initiation (GO:0006270)3.93465120
41spindle assembly checkpoint (GO:0071173)3.92603430
42negative regulation of chromosome segregation (GO:0051985)3.92099465
43regulation of mitotic metaphase/anaphase transition (GO:0030071)3.90588575
44mitotic spindle checkpoint (GO:0071174)3.87149914
45negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.86828231
46negative regulation of sister chromatid segregation (GO:0033046)3.86828231
47negative regulation of mitotic sister chromatid separation (GO:2000816)3.86828231
48negative regulation of mitotic sister chromatid segregation (GO:0033048)3.86828231
49DNA strand elongation involved in DNA replication (GO:0006271)3.86388706
50regulation of sister chromatid cohesion (GO:0007063)3.83348378
51mitotic spindle assembly checkpoint (GO:0007094)3.81959319
52regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.80694410
53DNA replication-dependent nucleosome assembly (GO:0006335)3.76042402
54DNA replication-dependent nucleosome organization (GO:0034723)3.76042402
55regulation of mitotic sister chromatid separation (GO:0010965)3.70986821
56regulation of mitotic sister chromatid segregation (GO:0033047)3.70986821
57regulation of sister chromatid segregation (GO:0033045)3.70986821
58DNA strand elongation (GO:0022616)3.70683940
59mitotic sister chromatid cohesion (GO:0007064)3.64893011
60chromosome condensation (GO:0030261)3.64409514
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.63499326
62chromatin assembly or disassembly (GO:0006333)3.60848129
63regulation of DNA endoreduplication (GO:0032875)3.60131298
64mitotic recombination (GO:0006312)3.52098848
65ventricular cardiac muscle cell development (GO:0055015)3.51544418
66telomere maintenance via semi-conservative replication (GO:0032201)3.50289741
67protein K6-linked ubiquitination (GO:0085020)3.47552439
68regulation of centrosome cycle (GO:0046605)3.46343881
69telomere maintenance via recombination (GO:0000722)3.44769997
70microtubule depolymerization (GO:0007019)3.43830723
71double-strand break repair via nonhomologous end joining (GO:0006303)3.41484671
72non-recombinational repair (GO:0000726)3.41484671
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.39015439
74nuclear envelope organization (GO:0006998)3.38466093
75pore complex assembly (GO:0046931)3.35908023
76ATP-dependent chromatin remodeling (GO:0043044)3.29308409
77spindle assembly involved in mitosis (GO:0090307)3.28478902
78regulation of centrosome duplication (GO:0010824)3.25511242
79mitotic spindle organization (GO:0007052)3.24326316
80DNA packaging (GO:0006323)3.23600035
81mitotic cytokinesis (GO:0000281)3.19896668
82protein complex localization (GO:0031503)3.19653062
83nucleobase biosynthetic process (GO:0046112)3.16297782
84telomere maintenance via telomere lengthening (GO:0010833)3.15739672
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14767841
86histone-serine phosphorylation (GO:0035404)3.14558519
87DNA topological change (GO:0006265)3.13903682
88regulation of double-strand break repair via homologous recombination (GO:0010569)3.13069205
89regulation of exit from mitosis (GO:0007096)3.11664411
90replication fork processing (GO:0031297)3.10050414
91formation of translation preinitiation complex (GO:0001731)3.09710383
92DNA geometric change (GO:0032392)3.08016625
93negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.07212545
94DNA duplex unwinding (GO:0032508)3.07148950
95ribosome assembly (GO:0042255)3.04750801
96* mitotic cell cycle (GO:0000278)3.04713338
97regulation of centriole replication (GO:0046599)3.03927272
98establishment of viral latency (GO:0019043)3.03788063
99negative regulation of cell division (GO:0051782)3.03684236
100regulation of spindle checkpoint (GO:0090231)3.03329753
101DNA conformation change (GO:0071103)3.03101554
102negative regulation of mitosis (GO:0045839)3.02389917
103regulation of telomere maintenance via telomerase (GO:0032210)2.99164061
104negative regulation of histone methylation (GO:0031061)2.95079462
105purine nucleobase biosynthetic process (GO:0009113)2.94754913
106maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93350791
107maturation of SSU-rRNA (GO:0030490)2.91711490
108folic acid-containing compound biosynthetic process (GO:0009396)2.91630078
109mitotic G2/M transition checkpoint (GO:0044818)2.90383249
110histone H2A monoubiquitination (GO:0035518)2.89411115
111nucleotide-excision repair, DNA gap filling (GO:0006297)2.89088683
112chromosome organization (GO:0051276)2.83990695
113maturation of 5.8S rRNA (GO:0000460)2.83870187
114mitotic nuclear division (GO:0007067)2.82881943
115regulation of histone H3-K9 methylation (GO:0051570)2.78438787
116somatic hypermutation of immunoglobulin genes (GO:0016446)2.77552401
117somatic diversification of immune receptors via somatic mutation (GO:0002566)2.77552401
118negative regulation of chromosome organization (GO:2001251)2.76105131

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.47745494
2* FOXM1_23109430_ChIP-Seq_U2OS_Human7.21235453
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.62299907
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.44318181
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.62430176
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.93281319
7* AR_21909140_ChIP-Seq_LNCAP_Human2.92427245
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79272553
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.68688043
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64215904
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49036702
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.37491855
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.34619373
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34487710
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30210212
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28249575
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.26426038
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22656449
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.17686148
20* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10819283
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.09125239
22XRN2_22483619_ChIP-Seq_HELA_Human2.03980095
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00588031
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98130160
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87928774
26VDR_23849224_ChIP-Seq_CD4+_Human1.87844432
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85721481
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79291987
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74907556
30FOXP3_21729870_ChIP-Seq_TREG_Human1.72513444
31DCP1A_22483619_ChIP-Seq_HELA_Human1.69101620
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68442797
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68364692
34MYC_22102868_ChIP-Seq_BL_Human1.63456536
35* TTF2_22483619_ChIP-Seq_HELA_Human1.59486447
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.58706426
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58694586
38CIITA_25753668_ChIP-Seq_RAJI_Human1.57254627
39* GABP_19822575_ChIP-Seq_HepG2_Human1.56652491
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.56501609
41KDM5A_27292631_Chip-Seq_BREAST_Human1.51089206
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49677626
43ELK1_19687146_ChIP-ChIP_HELA_Human1.47380293
44* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41789360
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40911440
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35711107
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34934020
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34370539
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34301591
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33942755
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29655049
52* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.27285971
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27125948
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26571434
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24799167
56* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23117846
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20121778
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19043028
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17849154
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15705681
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15024940
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13755365
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13704563
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13645584
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11626432
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09281099
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08750279
68* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08359703
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07170710
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06820517
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06441060
72TFEB_21752829_ChIP-Seq_HELA_Human1.04201213
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.03402307
74* NANOG_21062744_ChIP-ChIP_HESCs_Human1.03398634
75* SOX17_20123909_ChIP-Seq_XEN_Mouse1.01961461
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.00315656
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98203037
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97507512
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95510353
80ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95431750
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93384549
82SOX2_16153702_ChIP-ChIP_HESCs_Human0.92383342
83* MYC_18940864_ChIP-ChIP_HL60_Human0.91463241
84VDR_21846776_ChIP-Seq_THP-1_Human0.90494519
85EWS_26573619_Chip-Seq_HEK293_Human0.90326615
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89416761
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88596890
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87517698
89SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87403222
90POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87033006
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86835203
92TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84802824
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84774761
94SRF_21415370_ChIP-Seq_HL-1_Mouse0.84545522
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83528576
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82973958
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81439516
98SPI1_23547873_ChIP-Seq_NB4_Human0.79777787
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78930059
100ESR1_15608294_ChIP-ChIP_MCF-7_Human0.73349756
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.72948189
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72939035
103CHD1_26751641_Chip-Seq_LNCaP_Human0.69797933
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.69785224
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69207010
106CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.68948999
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.68728666
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68330009
109TCF3_18692474_ChIP-Seq_MESCs_Mouse0.66711166
110* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.66699500
111* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.66102158
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.65585259
113* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.65473858
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.65176447
115NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.63648790
116FUS_26573619_Chip-Seq_HEK293_Human0.63478060
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.61843545

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.59338593
2MP0003111_abnormal_nucleus_morphology4.94392023
3MP0010094_abnormal_chromosome_stability4.91070600
4MP0003077_abnormal_cell_cycle4.28750581
5MP0004957_abnormal_blastocyst_morpholog4.22989405
6MP0008057_abnormal_DNA_replication3.57521826
7MP0008058_abnormal_DNA_repair2.82462708
8MP0008007_abnormal_cellular_replicative2.82000644
9MP0008932_abnormal_embryonic_tissue2.59689218
10MP0003123_paternal_imprinting2.51855642
11MP0001730_embryonic_growth_arrest2.41366978
12MP0008877_abnormal_DNA_methylation2.32839725
13MP0003718_maternal_effect2.32698818
14MP0000350_abnormal_cell_proliferation2.31485249
15MP0010307_abnormal_tumor_latency2.20961335
16MP0009697_abnormal_copulation2.18054558
17MP0002396_abnormal_hematopoietic_system2.16690013
18MP0010352_gastrointestinal_tract_polyps1.96838120
19MP0001672_abnormal_embryogenesis/_devel1.91754092
20MP0005380_embryogenesis_phenotype1.91754092
21MP0001697_abnormal_embryo_size1.87029277
22MP0003786_premature_aging1.71404668
23MP0002085_abnormal_embryonic_tissue1.69809661
24MP0003984_embryonic_growth_retardation1.68779527
25MP0002088_abnormal_embryonic_growth/wei1.64909691
26MP0003950_abnormal_plasma_membrane1.63169802
27MP0005076_abnormal_cell_differentiation1.61243956
28MP0000490_abnormal_crypts_of1.61016636
29MP0003121_genomic_imprinting1.60490424
30MP0002080_prenatal_lethality1.58883306
31MP0002084_abnormal_developmental_patter1.58672639
32MP0004808_abnormal_hematopoietic_stem1.57804406
33MP0002086_abnormal_extraembryonic_tissu1.53029156
34MP0002019_abnormal_tumor_incidence1.42065809
35MP0002877_abnormal_melanocyte_morpholog1.39152002
36MP0002210_abnormal_sex_determination1.37597624
37MP0003567_abnormal_fetal_cardiomyocyte1.37236807
38MP0004197_abnormal_fetal_growth/weight/1.36786539
39MP0000313_abnormal_cell_death1.36407852
40MP0010030_abnormal_orbit_morphology1.33987721
41MP0003705_abnormal_hypodermis_morpholog1.24582997
42MP0002697_abnormal_eye_size1.23992548
43MP0001929_abnormal_gametogenesis1.22041556
44MP0005397_hematopoietic_system_phenotyp1.17158979
45MP0001545_abnormal_hematopoietic_system1.17158979
46MP0002938_white_spotting1.15728403
47MP0001119_abnormal_female_reproductive1.15097045
48MP0001145_abnormal_male_reproductive1.14289740
49MP0003937_abnormal_limbs/digits/tail_de1.13802906
50MP0000653_abnormal_sex_gland1.13509784
51MP0003890_abnormal_embryonic-extraembry1.12558995
52MP0003315_abnormal_perineum_morphology1.11705560
53MP0003806_abnormal_nucleotide_metabolis1.09963492
54MP0005623_abnormal_meninges_morphology1.08528313
55MP0004264_abnormal_extraembryonic_tissu1.00256471
56MP0009333_abnormal_splenocyte_physiolog0.97819196
57MP0001915_intracranial_hemorrhage0.96720318
58MP0001293_anophthalmia0.96344993
59MP0002233_abnormal_nose_morphology0.96223656
60MP0000703_abnormal_thymus_morphology0.96108971
61MP0009278_abnormal_bone_marrow0.95832266
62MP0002653_abnormal_ependyma_morphology0.95636303
63MP0001346_abnormal_lacrimal_gland0.93427818
64MP0009053_abnormal_anal_canal0.93380668
65MP0002234_abnormal_pharynx_morphology0.93095744
66MP0000537_abnormal_urethra_morphology0.91253512
67MP0005621_abnormal_cell_physiology0.88293532
68MP0009672_abnormal_birth_weight0.88250488
69MP0005023_abnormal_wound_healing0.87066026
70MP0002398_abnormal_bone_marrow0.86155962
71MP0003699_abnormal_female_reproductive0.86013791
72MP0000579_abnormal_nail_morphology0.85963084
73MP0006054_spinal_hemorrhage0.85537848
74MP0003941_abnormal_skin_development0.85090615
75MP0010234_abnormal_vibrissa_follicle0.82865984
76MP0000762_abnormal_tongue_morphology0.82419636
77MP0004233_abnormal_muscle_weight0.82400759
78MP0006035_abnormal_mitochondrial_morpho0.82221670
79MP0002722_abnormal_immune_system0.81667814
80MP0005384_cellular_phenotype0.81632044
81MP0003763_abnormal_thymus_physiology0.81545550
82MP0000372_irregular_coat_pigmentation0.81198776
83MP0003119_abnormal_digestive_system0.81088708
84MP0001849_ear_inflammation0.79516234
85MP0003566_abnormal_cell_adhesion0.79428626
86MP0002111_abnormal_tail_morphology0.78969876
87MP0005395_other_phenotype0.77513892
88MP0000689_abnormal_spleen_morphology0.76272669
89MP0002102_abnormal_ear_morphology0.75793075
90MP0000647_abnormal_sebaceous_gland0.75705167
91MP0003861_abnormal_nervous_system0.74646486
92MP0009703_decreased_birth_body0.73936590
93MP0003136_yellow_coat_color0.73906483
94MP0003943_abnormal_hepatobiliary_system0.73579612
95MP0005501_abnormal_skin_physiology0.73540412
96MP0001299_abnormal_eye_distance/0.73135809
97MP0000733_abnormal_muscle_development0.71947849
98MP0000858_altered_metastatic_potential0.71262313
99MP0001661_extended_life_span0.70121361
100MP0008789_abnormal_olfactory_epithelium0.68970293
101MP0001286_abnormal_eye_development0.67928967
102MP0000432_abnormal_head_morphology0.67398967
103MP0000428_abnormal_craniofacial_morphol0.65137647
104MP0006292_abnormal_olfactory_placode0.65135583
105MP0005389_reproductive_system_phenotype0.64962059
106MP0002092_abnormal_eye_morphology0.64800130
107MP0004272_abnormal_basement_membrane0.64729312
108MP0002161_abnormal_fertility/fecundity0.63609319
109MP0003385_abnormal_body_wall0.63217134
110MP0003935_abnormal_craniofacial_develop0.63019967
111MP0000477_abnormal_intestine_morphology0.62525098
112MP0002925_abnormal_cardiovascular_devel0.62425406
113MP0002429_abnormal_blood_cell0.62026132
114MP0002060_abnormal_skin_morphology0.61948873
115MP0003115_abnormal_respiratory_system0.61666400
116MP0002932_abnormal_joint_morphology0.61357440
117MP0000049_abnormal_middle_ear0.61152100
118MP0009250_abnormal_appendicular_skeleto0.60937047
119MP0003942_abnormal_urinary_system0.60218411
120MP0002114_abnormal_axial_skeleton0.60189638
121MP0001727_abnormal_embryo_implantation0.59620165
122MP0002177_abnormal_outer_ear0.58403796
123MP0003755_abnormal_palate_morphology0.56073655
124MP0000569_abnormal_digit_pigmentation0.55960150
125MP0000627_abnormal_mammary_gland0.55776516
126MP0002160_abnormal_reproductive_system0.55681973
127MP0005451_abnormal_body_composition0.55350576
128MP0000383_abnormal_hair_follicle0.52790579
129MP0003221_abnormal_cardiomyocyte_apopto0.52623150
130MP0000358_abnormal_cell_content/0.52024133
131MP0003448_altered_tumor_morphology0.50371441
132MP0001919_abnormal_reproductive_system0.50124487
133MP0000716_abnormal_immune_system0.48917798
134MP0005408_hypopigmentation0.48616006

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.81684553
2Chromsome breakage (HP:0040012)4.69853914
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.35330497
4Breast hypoplasia (HP:0003187)4.00745118
5Patellar aplasia (HP:0006443)3.73855947
6Abnormality of chromosome stability (HP:0003220)3.60832440
7Impulsivity (HP:0100710)3.60560366
8Aplasia/Hypoplasia of the patella (HP:0006498)3.50070874
9Meckel diverticulum (HP:0002245)3.33658948
10Abnormality of the preputium (HP:0100587)3.28176413
11Duodenal stenosis (HP:0100867)3.22899102
12Small intestinal stenosis (HP:0012848)3.22899102
13Abnormality of the labia minora (HP:0012880)3.18024771
14Carpal bone hypoplasia (HP:0001498)3.16405187
15Abnormality of the ileum (HP:0001549)3.14519919
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.09610364
17Cortical dysplasia (HP:0002539)3.08927563
18Selective tooth agenesis (HP:0001592)3.03084316
19Myelodysplasia (HP:0002863)2.98500156
20Colon cancer (HP:0003003)2.96894798
21Abnormal lung lobation (HP:0002101)2.89301010
22Medulloblastoma (HP:0002885)2.88274242
23Reticulocytopenia (HP:0001896)2.86731393
24Increased nuchal translucency (HP:0010880)2.83069950
25Absent radius (HP:0003974)2.80655371
26Ectopic kidney (HP:0000086)2.76922297
27Ependymoma (HP:0002888)2.70380811
28Volvulus (HP:0002580)2.69422004
29Sloping forehead (HP:0000340)2.68894400
30Abnormality of the anterior horn cell (HP:0006802)2.67109007
31Degeneration of anterior horn cells (HP:0002398)2.67109007
32Facial hemangioma (HP:0000329)2.63261537
33Abnormality of the duodenum (HP:0002246)2.61648669
34Aplasia involving forearm bones (HP:0009822)2.61403693
35Absent forearm bone (HP:0003953)2.61403693
36Rhabdomyosarcoma (HP:0002859)2.61373001
37Aplasia/Hypoplasia of the sacrum (HP:0008517)2.59386065
38Nephroblastoma (Wilms tumor) (HP:0002667)2.56231328
39Aplasia/Hypoplasia of the sternum (HP:0006714)2.46835647
40Oral leukoplakia (HP:0002745)2.45049154
41Supernumerary spleens (HP:0009799)2.41621964
42Deviation of the thumb (HP:0009603)2.41600955
43Embryonal renal neoplasm (HP:0011794)2.41066495
44Short 4th metacarpal (HP:0010044)2.40411341
45Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.40411341
46Proximal placement of thumb (HP:0009623)2.38974220
47Rough bone trabeculation (HP:0100670)2.35728787
48Bone marrow hypocellularity (HP:0005528)2.32275232
49Cafe-au-lait spot (HP:0000957)2.30507562
50Absent thumb (HP:0009777)2.27662334
51Choanal atresia (HP:0000453)2.26918934
52Short thumb (HP:0009778)2.24665586
53Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.23569502
54Premature ovarian failure (HP:0008209)2.23115597
55Abnormality of the carotid arteries (HP:0005344)2.22923357
56Atresia of the external auditory canal (HP:0000413)2.19012890
57Prominent nose (HP:0000448)2.17925809
58Neoplasm of the pancreas (HP:0002894)2.17820838
59Glioma (HP:0009733)2.14507400
60Horseshoe kidney (HP:0000085)2.14207857
61Agnosia (HP:0010524)2.13889215
62Abnormality of the umbilical cord (HP:0010881)2.12516936
63Duplicated collecting system (HP:0000081)2.11625341
64Aplastic anemia (HP:0001915)2.10019349
65Squamous cell carcinoma (HP:0002860)2.09986266
66Abnormal umbilical cord blood vessels (HP:0011403)2.09792950
67Single umbilical artery (HP:0001195)2.09792950
68Abnormality of the fetal cardiovascular system (HP:0010948)2.09792950
69High pitched voice (HP:0001620)2.09502335
70Overlapping toe (HP:0001845)2.09017174
71Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08403035
72Tracheoesophageal fistula (HP:0002575)2.07453528
73Deep philtrum (HP:0002002)2.06146920
74Hypoplastic pelvis (HP:0008839)2.05456056
75Embryonal neoplasm (HP:0002898)2.05372273
76Neoplasm of the colon (HP:0100273)1.99691572
77Abnormal number of incisors (HP:0011064)1.98293693
7811 pairs of ribs (HP:0000878)1.97976752
79Clubbing of toes (HP:0100760)1.97956430
80Shawl scrotum (HP:0000049)1.96394446
81Basal cell carcinoma (HP:0002671)1.96112706
82Duplication of thumb phalanx (HP:0009942)1.96110192
83Neoplasm of striated muscle (HP:0009728)1.96026636
84Secondary amenorrhea (HP:0000869)1.93989587
85Facial cleft (HP:0002006)1.92616410
86Male infertility (HP:0003251)1.92614228
87Abnormality of the renal collecting system (HP:0004742)1.91882301
88Abnormality of the fingertips (HP:0001211)1.91474277
89Triphalangeal thumb (HP:0001199)1.91430928
90Ureteral duplication (HP:0000073)1.91355827
91Abnormality of the calcaneus (HP:0008364)1.91187327
92Abnormality of chromosome segregation (HP:0002916)1.90084496
93Oligodactyly (HP:0012165)1.89089639
94Sandal gap (HP:0001852)1.88854876
95Multiple enchondromatosis (HP:0005701)1.88676075
96Abnormality of the proximal phalanges of the hand (HP:0009834)1.88097130
97Ankle contracture (HP:0006466)1.85851197
98Acute myeloid leukemia (HP:0004808)1.85584565
99Premature graying of hair (HP:0002216)1.85560224
100Entropion (HP:0000621)1.83188074
101Abnormality of the astrocytes (HP:0100707)1.81074049
102Astrocytoma (HP:0009592)1.81074049
103Neoplasm of the oral cavity (HP:0100649)1.79232656
104Abnormal auditory evoked potentials (HP:0006958)1.78579153
105Long eyelashes (HP:0000527)1.78407506
106Spinal muscular atrophy (HP:0007269)1.77194138
107Arteriovenous malformation (HP:0100026)1.76779214
108Abnormality of DNA repair (HP:0003254)1.75608791
109Slender long bone (HP:0003100)1.74432946
110Microglossia (HP:0000171)1.74323213
111Biliary tract neoplasm (HP:0100574)1.73627905
112Cellular immunodeficiency (HP:0005374)1.72911175
113Gastrointestinal carcinoma (HP:0002672)1.72750247
114Malignant gastrointestinal tract tumors (HP:0006749)1.72750247
115Capillary hemangiomas (HP:0005306)1.72349669
116Microtia (HP:0008551)1.71142606
117High anterior hairline (HP:0009890)1.66461933
118Absent epiphyses (HP:0010577)1.64518418
119Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.64518418
120Missing ribs (HP:0000921)1.62820554
121Abnormalities of placenta or umbilical cord (HP:0001194)1.59104094
122Abnormality of the septum pellucidum (HP:0007375)1.54267168
123Ovarian neoplasm (HP:0100615)1.54172550
124Microvesicular hepatic steatosis (HP:0001414)1.53918957
125Abnormality of glycolysis (HP:0004366)1.53568512
126Small hand (HP:0200055)1.52125680
127Progressive external ophthalmoplegia (HP:0000590)1.52058341
128Abnormality of cochlea (HP:0000375)1.51551488
129Bifid tongue (HP:0010297)1.49403072
130Abnormality of methionine metabolism (HP:0010901)1.49148061
131Oligodactyly (hands) (HP:0001180)1.48102898
132Poikiloderma (HP:0001029)1.47164566
133Hypopigmentation of the fundus (HP:0007894)1.46514877

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.11806240
2CDC74.42251197
3WEE14.18493769
4NEK23.67840365
5TTK3.47161040
6BRSK22.89082539
7PLK42.61464117
8NEK12.44625763
9* PLK12.35905688
10EIF2AK12.24538425
11STK102.18168259
12CDK122.14283118
13* AURKB1.95690454
14SRPK11.95289988
15PLK31.93521423
16BRSK11.89827434
17ACVR1B1.83355321
18CHEK21.82278681
19MAP3K81.66118894
20LATS11.59406109
21ATR1.56004970
22CDK71.54820696
23MELK1.53859315
24TSSK61.53594739
25VRK21.51376027
26MKNK11.49074394
27CDK41.47091343
28EEF2K1.42863026
29STK41.42726127
30CCNB11.41701943
31MST41.41143094
32TRIM281.40746651
33STK31.40062523
34TAF11.40029311
35MST1R1.39135157
36RPS6KB21.37793804
37CHEK11.35088556
38AURKA1.31976275
39PASK1.27460101
40MKNK21.22438956
41RPS6KA41.20891423
42VRK11.19918749
43LATS21.12723786
44TESK21.12401432
45STK38L1.10791926
46TLK11.09345899
47EPHA21.08839884
48MET1.06625263
49MOS1.01923671
50CDK61.01630264
51ATM1.01291190
52DYRK31.00507388
53EIF2AK30.94205514
54BRAF0.93058217
55CDK80.92106011
56PAK40.90076650
57CDK20.89189199
58ERBB40.87098061
59TGFBR10.83718745
60PKN20.83401079
61BRD40.82081020
62MAP3K100.79221628
63CDK10.77720072
64NME20.75367681
65ZAK0.71683411
66TAOK30.69889347
67PIM10.69678793
68SMG10.69326729
69LRRK20.63008433
70PAK10.62229953
71PLK20.60441986
72CDK90.56330353
73BMPR1B0.55535252
74EIF2AK20.55516911
75ERBB30.55034891
76CLK10.53762711
77ALK0.52626382
78MARK30.52059620
79FLT30.51269007
80MAP3K60.51183687
81BMPR20.50245062
82NUAK10.48700589
83MTOR0.46370796
84PRKCI0.44190626
85CSNK2A10.44156017
86BCR0.44030358
87PNCK0.43385633
88NEK90.43262676
89NME10.43019663
90PBK0.42025805
91CSNK2A20.40990812
92CDK180.40547909
93TNIK0.40342898
94PDK20.39536681
95MAP4K10.37771834
96CDK150.36736924
97SCYL20.35052060
98CDK11A0.34149487
99FGFR10.33444042
100PRKDC0.32575091
101PTK20.32097604
102CDK140.29662424
103MAPK140.27744816
104AKT20.26300116
105RAF10.25678707
106PDK30.25373527
107PDK40.25373527
108CSNK1E0.25190636
109RPS6KA50.25103020
110CSNK1D0.23180465
111CHUK0.22190209
112STK160.21991747
113PAK20.21431735
114AKT10.21252445
115MAPK10.20950907
116TTN0.20408667
117CDK30.19719113
118CSNK1G10.18650085
119MAPKAPK20.17709770
120KSR10.17059031
121GSK3B0.16480271
122STK240.16316921
123CSNK1G30.15429089
124WNK30.15346567
125NEK60.14616889

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.47280579
2Mismatch repair_Homo sapiens_hsa034303.97275030
3Cell cycle_Homo sapiens_hsa041103.73965944
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.52499392
5RNA transport_Homo sapiens_hsa030133.32887682
6Homologous recombination_Homo sapiens_hsa034403.17076974
7Base excision repair_Homo sapiens_hsa034103.13897909
8Spliceosome_Homo sapiens_hsa030403.04377924
9RNA polymerase_Homo sapiens_hsa030202.74371177
10Nucleotide excision repair_Homo sapiens_hsa034202.74085834
11Fanconi anemia pathway_Homo sapiens_hsa034602.65375956
12Non-homologous end-joining_Homo sapiens_hsa034502.40831369
13Basal transcription factors_Homo sapiens_hsa030222.31320703
14RNA degradation_Homo sapiens_hsa030182.21715857
15One carbon pool by folate_Homo sapiens_hsa006702.15207467
16p53 signaling pathway_Homo sapiens_hsa041152.12004269
17Proteasome_Homo sapiens_hsa030502.01314758
18Pyrimidine metabolism_Homo sapiens_hsa002402.01094343
19mRNA surveillance pathway_Homo sapiens_hsa030152.00758712
20Ribosome_Homo sapiens_hsa030101.95229406
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89199523
22Oocyte meiosis_Homo sapiens_hsa041141.71271676
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.69096177
24Vitamin B6 metabolism_Homo sapiens_hsa007501.40665378
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34124350
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33339581
27Epstein-Barr virus infection_Homo sapiens_hsa051691.23277342
28Systemic lupus erythematosus_Homo sapiens_hsa053221.21242740
29Protein export_Homo sapiens_hsa030601.18206352
30Viral carcinogenesis_Homo sapiens_hsa052031.14117480
31Pyruvate metabolism_Homo sapiens_hsa006201.11360804
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11280897
33* MicroRNAs in cancer_Homo sapiens_hsa052061.09230626
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08721397
35Herpes simplex infection_Homo sapiens_hsa051681.06545578
36Purine metabolism_Homo sapiens_hsa002301.05389298
37Small cell lung cancer_Homo sapiens_hsa052221.02860335
38HTLV-I infection_Homo sapiens_hsa051660.96114365
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95248790
40Carbon metabolism_Homo sapiens_hsa012000.91202850
41Antigen processing and presentation_Homo sapiens_hsa046120.89839228
42Steroid biosynthesis_Homo sapiens_hsa001000.84445863
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80730136
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80719700
45Thyroid cancer_Homo sapiens_hsa052160.79064212
46TGF-beta signaling pathway_Homo sapiens_hsa043500.76313915
47Hippo signaling pathway_Homo sapiens_hsa043900.72075981
48Propanoate metabolism_Homo sapiens_hsa006400.71606437
49Colorectal cancer_Homo sapiens_hsa052100.71423741
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71315865
51N-Glycan biosynthesis_Homo sapiens_hsa005100.70589922
52Fatty acid elongation_Homo sapiens_hsa000620.69972621
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69489677
54Adherens junction_Homo sapiens_hsa045200.63924933
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63254606
56Chronic myeloid leukemia_Homo sapiens_hsa052200.62547650
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.62451731
58Pentose phosphate pathway_Homo sapiens_hsa000300.62229793
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61486009
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59933452
61Pancreatic cancer_Homo sapiens_hsa052120.59795080
62Apoptosis_Homo sapiens_hsa042100.58869002
63Selenocompound metabolism_Homo sapiens_hsa004500.57399288
64Biosynthesis of amino acids_Homo sapiens_hsa012300.55899649
65Folate biosynthesis_Homo sapiens_hsa007900.54538745
66Hepatitis B_Homo sapiens_hsa051610.52921166
67Notch signaling pathway_Homo sapiens_hsa043300.52528041
68Basal cell carcinoma_Homo sapiens_hsa052170.50354006
69Huntingtons disease_Homo sapiens_hsa050160.49046777
70FoxO signaling pathway_Homo sapiens_hsa040680.47183802
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46483072
72Shigellosis_Homo sapiens_hsa051310.45855568
73mTOR signaling pathway_Homo sapiens_hsa041500.45509374
74Primary immunodeficiency_Homo sapiens_hsa053400.44924418
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.44185944
76Bladder cancer_Homo sapiens_hsa052190.43993052
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43185709
78Pathways in cancer_Homo sapiens_hsa052000.42887529
79Sulfur relay system_Homo sapiens_hsa041220.42666454
80Prostate cancer_Homo sapiens_hsa052150.41879227
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40813185
82Influenza A_Homo sapiens_hsa051640.38676370
83Viral myocarditis_Homo sapiens_hsa054160.38643049
84Non-small cell lung cancer_Homo sapiens_hsa052230.38474542
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.38331684
86Legionellosis_Homo sapiens_hsa051340.37544648
87Lysine degradation_Homo sapiens_hsa003100.37377742
88Hedgehog signaling pathway_Homo sapiens_hsa043400.36777128
89Measles_Homo sapiens_hsa051620.36352493
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34847008
91HIF-1 signaling pathway_Homo sapiens_hsa040660.34559233
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34185235
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34097540
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33996654
95Alcoholism_Homo sapiens_hsa050340.33075657
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.32611457
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31978730
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31262446
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30708832
100Metabolic pathways_Homo sapiens_hsa011000.30431927
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29262668
102Proteoglycans in cancer_Homo sapiens_hsa052050.27153464
103Endometrial cancer_Homo sapiens_hsa052130.26811852
104Glutathione metabolism_Homo sapiens_hsa004800.26481808
105Hematopoietic cell lineage_Homo sapiens_hsa046400.26143454
106Tight junction_Homo sapiens_hsa045300.25872390
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.25252679
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25167212
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25113406
110Parkinsons disease_Homo sapiens_hsa050120.25001680
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.23903516
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.23706716
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22575390
114Wnt signaling pathway_Homo sapiens_hsa043100.21625640
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19848231
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18660256
117Melanoma_Homo sapiens_hsa052180.18124584
118Arginine and proline metabolism_Homo sapiens_hsa003300.17044500
119B cell receptor signaling pathway_Homo sapiens_hsa046620.16680464
120Acute myeloid leukemia_Homo sapiens_hsa052210.16666450
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15897313
122Toxoplasmosis_Homo sapiens_hsa051450.15434035
123Galactose metabolism_Homo sapiens_hsa000520.15231971
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14970881
125Fructose and mannose metabolism_Homo sapiens_hsa000510.14805975
126ECM-receptor interaction_Homo sapiens_hsa045120.13661295
127Renin-angiotensin system_Homo sapiens_hsa046140.13532317
128Fatty acid metabolism_Homo sapiens_hsa012120.12896421
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12871876
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08580109

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