KIF22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.75461678
2mitotic metaphase plate congression (GO:0007080)5.41043585
3protein localization to chromosome, centromeric region (GO:0071459)5.08109242
4mitotic sister chromatid segregation (GO:0000070)5.00974062
5DNA ligation (GO:0006266)4.95796955
6kinetochore organization (GO:0051383)4.78456157
7regulation of spindle organization (GO:0090224)4.78313603
8DNA strand elongation involved in DNA replication (GO:0006271)4.72823011
9metaphase plate congression (GO:0051310)4.72166280
10mitotic chromosome condensation (GO:0007076)4.68404353
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.66512094
12DNA unwinding involved in DNA replication (GO:0006268)4.65409650
13DNA replication initiation (GO:0006270)4.60327060
14sister chromatid segregation (GO:0000819)4.59607573
15DNA strand elongation (GO:0022616)4.49432457
16attachment of spindle microtubules to kinetochore (GO:0008608)4.46899242
17DNA replication checkpoint (GO:0000076)4.45840414
18telomere maintenance via semi-conservative replication (GO:0032201)4.40554261
19CENP-A containing nucleosome assembly (GO:0034080)4.40040524
20kinetochore assembly (GO:0051382)4.37864537
21mitotic nuclear envelope disassembly (GO:0007077)4.32277921
22establishment of chromosome localization (GO:0051303)4.31815926
23chromatin remodeling at centromere (GO:0031055)4.31399374
24establishment of integrated proviral latency (GO:0075713)4.29051419
25nucleobase biosynthetic process (GO:0046112)4.19230738
26regulation of mitotic spindle organization (GO:0060236)4.06408672
27DNA replication-independent nucleosome organization (GO:0034724)4.05631948
28DNA replication-independent nucleosome assembly (GO:0006336)4.05631948
29DNA replication-dependent nucleosome assembly (GO:0006335)4.04267838
30DNA replication-dependent nucleosome organization (GO:0034723)4.04267838
31nuclear envelope disassembly (GO:0051081)4.00181670
32membrane disassembly (GO:0030397)4.00181670
33telomere maintenance via recombination (GO:0000722)4.00057990
34mitotic recombination (GO:0006312)3.99655433
35positive regulation of chromosome segregation (GO:0051984)3.99313262
36purine nucleobase biosynthetic process (GO:0009113)3.98577004
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.96926994
38spindle checkpoint (GO:0031577)3.96235139
39nuclear pore organization (GO:0006999)3.88419606
40regulation of chromosome segregation (GO:0051983)3.86255036
41negative regulation of chromosome segregation (GO:0051985)3.79203533
42spindle assembly checkpoint (GO:0071173)3.75204398
43negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.74979217
44negative regulation of sister chromatid segregation (GO:0033046)3.74979217
45negative regulation of mitotic sister chromatid separation (GO:2000816)3.74979217
46negative regulation of mitotic sister chromatid segregation (GO:0033048)3.74979217
47histone exchange (GO:0043486)3.74034930
48formation of translation preinitiation complex (GO:0001731)3.71260129
49negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.69326565
50mitotic spindle assembly checkpoint (GO:0007094)3.68377068
51protein localization to chromosome (GO:0034502)3.67116466
52negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.66077103
53maturation of SSU-rRNA (GO:0030490)3.64951350
54mitotic spindle checkpoint (GO:0071174)3.64885078
55telomere maintenance via telomere lengthening (GO:0010833)3.63217433
56nuclear pore complex assembly (GO:0051292)3.62796089
57regulation of mitotic metaphase/anaphase transition (GO:0030071)3.61263389
58DNA packaging (GO:0006323)3.59735369
59mitotic sister chromatid cohesion (GO:0007064)3.58383051
60chromosome segregation (GO:0007059)3.55390129
61regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.54696206
62meiotic chromosome segregation (GO:0045132)3.53918037
63negative regulation of mRNA processing (GO:0050686)3.49724216
64regulation of sister chromatid segregation (GO:0033045)3.46042338
65regulation of mitotic sister chromatid separation (GO:0010965)3.46042338
66regulation of mitotic sister chromatid segregation (GO:0033047)3.46042338
67nucleotide-excision repair, DNA gap filling (GO:0006297)3.45383013
68heterochromatin organization (GO:0070828)3.44604361
69ribosome assembly (GO:0042255)3.40727913
70establishment of viral latency (GO:0019043)3.39979956
71ribosome biogenesis (GO:0042254)3.39627576
72DNA strand renaturation (GO:0000733)3.38813679
73IMP biosynthetic process (GO:0006188)3.38640096
74positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.37816272
75positive regulation of mitotic sister chromatid separation (GO:1901970)3.37816272
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.37816272
77viral mRNA export from host cell nucleus (GO:0046784)3.37494740
78ribosomal small subunit assembly (GO:0000028)3.32547199
79anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.29550410
80regulation of centrosome cycle (GO:0046605)3.27458716
81base-excision repair (GO:0006284)3.27329106
82DNA synthesis involved in DNA repair (GO:0000731)3.27228714
83chromatin assembly or disassembly (GO:0006333)3.25818155
84V(D)J recombination (GO:0033151)3.24779332
85DNA geometric change (GO:0032392)3.23612651
86pore complex assembly (GO:0046931)3.23512993
87DNA duplex unwinding (GO:0032508)3.23044308
88chromosome condensation (GO:0030261)3.22168620
89ribonucleoprotein complex biogenesis (GO:0022613)3.18574527
90DNA deamination (GO:0045006)3.18407959
91non-recombinational repair (GO:0000726)3.18184957
92double-strand break repair via nonhomologous end joining (GO:0006303)3.18184957
93negative regulation of mRNA metabolic process (GO:1903312)3.18126890
94regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.18115342
95spliceosomal snRNP assembly (GO:0000387)3.17093366
96regulation of sister chromatid cohesion (GO:0007063)3.15998279
97regulation of double-strand break repair via homologous recombination (GO:0010569)3.15185901
98ATP-dependent chromatin remodeling (GO:0043044)3.13950414
99nuclear envelope organization (GO:0006998)3.13766209
100histone-serine phosphorylation (GO:0035404)3.13129344
101ribosomal large subunit biogenesis (GO:0042273)3.10674887
102regulation of centriole replication (GO:0046599)3.10132199
103folic acid-containing compound biosynthetic process (GO:0009396)3.09690579
104mitotic cell cycle (GO:0000278)3.08643494
105regulation of translational fidelity (GO:0006450)3.08319590
106somatic hypermutation of immunoglobulin genes (GO:0016446)3.07785156
107somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07785156
108microtubule depolymerization (GO:0007019)3.07747489
109negative regulation of RNA splicing (GO:0033119)3.07135523
110regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04939291
111DNA topological change (GO:0006265)3.03526651
112rRNA processing (GO:0006364)3.03190537
113regulation of nuclear cell cycle DNA replication (GO:0033262)3.01792964
114protein complex localization (GO:0031503)3.01092006
115transcription-coupled nucleotide-excision repair (GO:0006283)3.00621337
116DNA conformation change (GO:0071103)3.00076642
117L-serine metabolic process (GO:0006563)2.97512717
118negative regulation of mitosis (GO:0045839)2.94604917
119protein K6-linked ubiquitination (GO:0085020)2.94427332
120rRNA metabolic process (GO:0016072)2.93631781
121spliceosomal complex assembly (GO:0000245)2.93582650
122maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92430260

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.11556627
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.03631870
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.22985708
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.02349769
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.89760267
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43001761
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19829159
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94349866
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.80751999
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.73368903
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72924930
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66550677
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.63448006
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63193725
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56575492
16AR_21909140_ChIP-Seq_LNCAP_Human2.49813833
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.47876223
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33730397
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33265724
20XRN2_22483619_ChIP-Seq_HELA_Human2.32184807
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15779593
22* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.11636325
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.08983748
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02318788
25* VDR_23849224_ChIP-Seq_CD4+_Human2.01542387
26NANOG_18555785_ChIP-Seq_MESCs_Mouse1.96059018
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90414979
28* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88653081
29FOXP3_21729870_ChIP-Seq_TREG_Human1.86802375
30DCP1A_22483619_ChIP-Seq_HELA_Human1.84600983
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82902497
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79181585
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.76379092
34TTF2_22483619_ChIP-Seq_HELA_Human1.76265162
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74965986
36GABP_19822575_ChIP-Seq_HepG2_Human1.72908272
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71333967
38CIITA_25753668_ChIP-Seq_RAJI_Human1.70288520
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62884266
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60805531
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57854466
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56386105
43* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55106204
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54411001
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.51950910
46MYC_22102868_ChIP-Seq_BL_Human1.46651006
47ELK1_19687146_ChIP-ChIP_HELA_Human1.45407663
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44571299
49KDM5A_27292631_Chip-Seq_BREAST_Human1.43687319
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43074481
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40837074
52SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40243477
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.39443926
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34608084
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34455714
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33320725
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31462820
58* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28788204
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28511478
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26307409
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25750536
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23215092
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21821474
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21569869
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20248280
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13319457
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12381383
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.11288568
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09637084
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08898145
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06624887
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05787963
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05010197
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03103487
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02068690
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01844881
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01717105
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.00255437
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99541634
80TFEB_21752829_ChIP-Seq_HELA_Human0.98324033
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95988290
82ZNF263_19887448_ChIP-Seq_K562_Human0.95709046
83* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95550874
84* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94622237
85TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93671042
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93008489
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92858324
88VDR_21846776_ChIP-Seq_THP-1_Human0.89389173
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89292503
90MYC_18940864_ChIP-ChIP_HL60_Human0.88985521
91* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88847445
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86698487
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86167850
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85711784
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85218327
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83307555
97* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82952486
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82290350
99KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82290350
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82290350
101SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81222220
102NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80957141
103OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80526003
104SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80507832
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79104233
106* FOXP1_21924763_ChIP-Seq_HESCs_Human0.78978331
107NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78542477
108RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77528559
109CHD1_26751641_Chip-Seq_LNCaP_Human0.77438713
110TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77322244
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76373700
112SALL1_21062744_ChIP-ChIP_HESCs_Human0.75863567
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.75369927
114SOX17_20123909_ChIP-Seq_XEN_Mouse0.73579269
115SOX2_16153702_ChIP-ChIP_HESCs_Human0.73180795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.03280966
2* MP0003111_abnormal_nucleus_morphology5.22637384
3MP0010094_abnormal_chromosome_stability5.13845001
4MP0004957_abnormal_blastocyst_morpholog4.68911847
5MP0003077_abnormal_cell_cycle4.50644168
6MP0008057_abnormal_DNA_replication4.11338020
7MP0008058_abnormal_DNA_repair3.27424811
8MP0008007_abnormal_cellular_replicative3.00043252
9MP0008932_abnormal_embryonic_tissue2.85313542
10MP0003123_paternal_imprinting2.79214143
11MP0001730_embryonic_growth_arrest2.57954754
12MP0000350_abnormal_cell_proliferation2.42614129
13MP0003718_maternal_effect2.11806090
14MP0010307_abnormal_tumor_latency2.09972331
15MP0008877_abnormal_DNA_methylation2.06388555
16MP0003786_premature_aging1.97811770
17* MP0005380_embryogenesis_phenotype1.93702488
18* MP0001672_abnormal_embryogenesis/_devel1.93702488
19MP0002396_abnormal_hematopoietic_system1.93564661
20MP0001697_abnormal_embryo_size1.88851492
21MP0009697_abnormal_copulation1.83871408
22MP0010352_gastrointestinal_tract_polyps1.82813528
23MP0003984_embryonic_growth_retardation1.72492800
24MP0002085_abnormal_embryonic_tissue1.71420200
25* MP0002080_prenatal_lethality1.71077384
26MP0002088_abnormal_embryonic_growth/wei1.68202916
27MP0003121_genomic_imprinting1.62839456
28MP0010030_abnormal_orbit_morphology1.56113909
29MP0000490_abnormal_crypts_of1.55750380
30MP0002084_abnormal_developmental_patter1.50986310
31MP0000313_abnormal_cell_death1.50022921
32MP0002086_abnormal_extraembryonic_tissu1.47277545
33MP0003567_abnormal_fetal_cardiomyocyte1.43325709
34MP0004197_abnormal_fetal_growth/weight/1.41944713
35MP0002019_abnormal_tumor_incidence1.40781755
36MP0001346_abnormal_lacrimal_gland1.38599700
37MP0005076_abnormal_cell_differentiation1.38457350
38MP0006035_abnormal_mitochondrial_morpho1.36535838
39MP0003315_abnormal_perineum_morphology1.34195074
40MP0004808_abnormal_hematopoietic_stem1.28093023
41MP0004185_abnormal_adipocyte_glucose1.27442353
42MP0002210_abnormal_sex_determination1.25947555
43MP0008260_abnormal_autophagy1.19261543
44MP0001293_anophthalmia1.15291277
45MP0009333_abnormal_splenocyte_physiolog1.14233166
46MP0006292_abnormal_olfactory_placode1.12427288
47MP0001145_abnormal_male_reproductive1.11436308
48MP0004233_abnormal_muscle_weight1.10480197
49MP0005501_abnormal_skin_physiology1.07044084
50MP0009053_abnormal_anal_canal1.07004721
51MP0002653_abnormal_ependyma_morphology1.04835637
52MP0003119_abnormal_digestive_system1.03680329
53MP0003890_abnormal_embryonic-extraembry1.03385314
54MP0001929_abnormal_gametogenesis1.02382335
55MP0000703_abnormal_thymus_morphology1.01546611
56MP0005451_abnormal_body_composition1.00696715
57MP0001545_abnormal_hematopoietic_system1.00196901
58MP0005397_hematopoietic_system_phenotyp1.00196901
59MP0008995_early_reproductive_senescence0.99133733
60MP0000653_abnormal_sex_gland0.96261051
61MP0003937_abnormal_limbs/digits/tail_de0.95581554
62MP0009672_abnormal_birth_weight0.95433262
63MP0000537_abnormal_urethra_morphology0.94812443
64MP0006036_abnormal_mitochondrial_physio0.94045581
65MP0003941_abnormal_skin_development0.91977207
66MP0002009_preneoplasia0.88640776
67MP0002697_abnormal_eye_size0.88322917
68MP0002111_abnormal_tail_morphology0.87536997
69MP0002722_abnormal_immune_system0.87000734
70MP0000566_synostosis0.86958800
71MP0001661_extended_life_span0.86800853
72MP0001119_abnormal_female_reproductive0.85692973
73MP0005384_cellular_phenotype0.82844359
74MP0002398_abnormal_bone_marrow0.82804036
75MP0002160_abnormal_reproductive_system0.80809766
76MP0002163_abnormal_gland_morphology0.79070897
77MP0005621_abnormal_cell_physiology0.78764320
78MP0000428_abnormal_craniofacial_morphol0.78128145
79MP0002132_abnormal_respiratory_system0.78049470
80MP0000689_abnormal_spleen_morphology0.77804997
81MP0000358_abnormal_cell_content/0.77218014
82MP0003186_abnormal_redox_activity0.75140327
83MP0003806_abnormal_nucleotide_metabolis0.74975735
84MP0001849_ear_inflammation0.74582260
85MP0009703_decreased_birth_body0.74238118
86MP0001727_abnormal_embryo_implantation0.73921184
87MP0004133_heterotaxia0.73860809
88MP0003938_abnormal_ear_development0.73787371
89MP0005389_reproductive_system_phenotype0.73572940
90MP0003698_abnormal_male_reproductive0.71502435
91MP0003763_abnormal_thymus_physiology0.70713260
92MP0001873_stomach_inflammation0.69517644
93MP0001529_abnormal_vocalization0.69512480
94MP0000858_altered_metastatic_potential0.69461846
95MP0004147_increased_porphyrin_level0.68869395
96MP0001286_abnormal_eye_development0.68417349
97MP0009278_abnormal_bone_marrow0.68158171
98MP0002877_abnormal_melanocyte_morpholog0.67594881
99MP0002092_abnormal_eye_morphology0.65488045
100MP0003221_abnormal_cardiomyocyte_apopto0.64071322
101MP0004264_abnormal_extraembryonic_tissu0.64070237
102MP0002429_abnormal_blood_cell0.63636661
103MP0001915_intracranial_hemorrhage0.63190785
104MP0003115_abnormal_respiratory_system0.62240442
105MP0002796_impaired_skin_barrier0.60653375
106MP0005023_abnormal_wound_healing0.59684752
107MP0003699_abnormal_female_reproductive0.59248080
108MP0002970_abnormal_white_adipose0.58889912
109MP0000432_abnormal_head_morphology0.56794793
110MP0003878_abnormal_ear_physiology0.56534219
111MP0005377_hearing/vestibular/ear_phenot0.56534219
112MP0003943_abnormal_hepatobiliary_system0.56522394
113MP0001881_abnormal_mammary_gland0.56153716
114MP0002932_abnormal_joint_morphology0.55900302
115MP0002102_abnormal_ear_morphology0.55325860
116MP0000477_abnormal_intestine_morphology0.54924695
117MP0006054_spinal_hemorrhage0.54833760
118MP0000678_abnormal_parathyroid_gland0.54671536
119MP0003935_abnormal_craniofacial_develop0.54464743
120MP0002938_white_spotting0.54234345
121MP0002161_abnormal_fertility/fecundity0.54217408
122MP0000372_irregular_coat_pigmentation0.54132255
123MP0003861_abnormal_nervous_system0.53804886
124MP0003705_abnormal_hypodermis_morpholog0.53521173
125MP0001919_abnormal_reproductive_system0.52846270
126MP0002114_abnormal_axial_skeleton0.51713420
127MP0002127_abnormal_cardiovascular_syste0.50390332
128MP0002249_abnormal_larynx_morphology0.50321055
129MP0005395_other_phenotype0.50222168
130MP0008789_abnormal_olfactory_epithelium0.49829235

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.94195198
2Breast hypoplasia (HP:0003187)4.46423747
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.29393118
4Chromsome breakage (HP:0040012)4.28696446
5Reticulocytopenia (HP:0001896)3.96492831
6Impulsivity (HP:0100710)3.73100044
7Meckel diverticulum (HP:0002245)3.52846908
8Selective tooth agenesis (HP:0001592)3.49723765
9Microvesicular hepatic steatosis (HP:0001414)3.43892429
10* Patellar aplasia (HP:0006443)3.41916777
11Abnormality of the ileum (HP:0001549)3.34462126
12Abnormality of chromosome stability (HP:0003220)3.33534519
13Colon cancer (HP:0003003)3.31930730
14Absent radius (HP:0003974)3.31309000
15Abnormality of cells of the erythroid lineage (HP:0012130)3.28725066
16Abnormality of the preputium (HP:0100587)3.27855577
17Ependymoma (HP:0002888)3.25094541
18* Aplasia/Hypoplasia of the patella (HP:0006498)3.25065198
19Small intestinal stenosis (HP:0012848)3.22924145
20Duodenal stenosis (HP:0100867)3.22924145
21Oral leukoplakia (HP:0002745)3.22219197
22Abnormal number of erythroid precursors (HP:0012131)3.21988610
23Medulloblastoma (HP:0002885)3.14676359
24Abnormality of the anterior horn cell (HP:0006802)3.13798897
25Degeneration of anterior horn cells (HP:0002398)3.13798897
26Aplasia/Hypoplasia of the uvula (HP:0010293)3.12480865
27Abnormality of the labia minora (HP:0012880)3.09341473
28Aplasia involving forearm bones (HP:0009822)3.08893619
29Absent forearm bone (HP:0003953)3.08893619
30Abnormal lung lobation (HP:0002101)3.05650982
31Rough bone trabeculation (HP:0100670)3.01197887
32Myelodysplasia (HP:0002863)2.79532723
33Absent thumb (HP:0009777)2.74851510
34Abnormality of cochlea (HP:0000375)2.74642591
35Rhabdomyosarcoma (HP:0002859)2.70166449
36Cholecystitis (HP:0001082)2.69717941
37Abnormal gallbladder physiology (HP:0012438)2.69717941
38Abnormal number of incisors (HP:0011064)2.68599781
39Cerebral hypomyelination (HP:0006808)2.67454483
40Abnormality of the duodenum (HP:0002246)2.66916849
41Horseshoe kidney (HP:0000085)2.62793916
42Sloping forehead (HP:0000340)2.61558141
43Progressive muscle weakness (HP:0003323)2.60888760
44Cortical dysplasia (HP:0002539)2.58694733
45Increased nuchal translucency (HP:0010880)2.54835740
46Bone marrow hypocellularity (HP:0005528)2.54061320
47Neoplasm of the pancreas (HP:0002894)2.52828691
48Abnormality of glycolysis (HP:0004366)2.51425871
49Nephroblastoma (Wilms tumor) (HP:0002667)2.51291392
50Supernumerary spleens (HP:0009799)2.49151640
51High anterior hairline (HP:0009890)2.48920030
52Ectopic kidney (HP:0000086)2.46870148
53Agnosia (HP:0010524)2.42573127
54Premature ovarian failure (HP:0008209)2.41192464
5511 pairs of ribs (HP:0000878)2.39838111
56Macrocytic anemia (HP:0001972)2.35104912
57Duplicated collecting system (HP:0000081)2.33705578
58Cafe-au-lait spot (HP:0000957)2.32764338
59Embryonal renal neoplasm (HP:0011794)2.32378361
60Tracheoesophageal fistula (HP:0002575)2.31654029
61Atresia of the external auditory canal (HP:0000413)2.29177837
62Embryonal neoplasm (HP:0002898)2.28482706
63Triphalangeal thumb (HP:0001199)2.28385536
64Multiple enchondromatosis (HP:0005701)2.28100646
65Premature graying of hair (HP:0002216)2.27850267
66Duplication of thumb phalanx (HP:0009942)2.23999243
67Facial hemangioma (HP:0000329)2.22768549
68Pallor (HP:0000980)2.22201705
69Trismus (HP:0000211)2.21733894
70Aplastic anemia (HP:0001915)2.21651233
71Progressive external ophthalmoplegia (HP:0000590)2.21346227
72Aplasia/Hypoplasia of the sternum (HP:0006714)2.20116331
73Cellular immunodeficiency (HP:0005374)2.18318279
74Proximal placement of thumb (HP:0009623)2.17071473
75Short thumb (HP:0009778)2.16631596
76Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15605934
77Overlapping toe (HP:0001845)2.14998464
78Microretrognathia (HP:0000308)2.14786391
79Increased serum pyruvate (HP:0003542)2.13071904
80Choanal atresia (HP:0000453)2.12732286
81Basal cell carcinoma (HP:0002671)2.12255415
82Abnormal trabecular bone morphology (HP:0100671)2.12126751
83Cleft eyelid (HP:0000625)2.11512509
84Abnormality of the carotid arteries (HP:0005344)2.10454190
85Morphological abnormality of the inner ear (HP:0011390)2.09444535
86Prominent nose (HP:0000448)2.09113124
87Glioma (HP:0009733)2.09075617
88Deviation of the thumb (HP:0009603)2.07117911
89Ureteral duplication (HP:0000073)2.06719304
90High pitched voice (HP:0001620)2.04148204
91Secondary amenorrhea (HP:0000869)2.03681734
92Squamous cell carcinoma (HP:0002860)2.03678361
93Ragged-red muscle fibers (HP:0003200)2.02962838
94Neoplasm of striated muscle (HP:0009728)2.02805252
95Pancytopenia (HP:0001876)1.98458825
96Atrophy/Degeneration involving motor neurons (HP:0007373)1.98148554
97Aplasia/hypoplasia of the humerus (HP:0006507)1.97645446
98Astrocytoma (HP:0009592)1.97578108
99Abnormality of the astrocytes (HP:0100707)1.97578108
100Abnormality of the renal collecting system (HP:0004742)1.96649762
101Neoplasm of the colon (HP:0100273)1.96636455
102Missing ribs (HP:0000921)1.96498234
103* Carpal bone hypoplasia (HP:0001498)1.93170356
104Short 4th metacarpal (HP:0010044)1.93089225
105Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93089225
106Volvulus (HP:0002580)1.89601300
107Arteriovenous malformation (HP:0100026)1.89365572
108Abnormality of reticulocytes (HP:0004312)1.86035227
109Spinal muscular atrophy (HP:0007269)1.84976083
110Poikiloderma (HP:0001029)1.83586208
111Abnormality of abdominal situs (HP:0011620)1.83074810
112Abdominal situs inversus (HP:0003363)1.83074810
113Hypoplastic pelvis (HP:0008839)1.80339542
114Oligodactyly (HP:0012165)1.79305852
115Slender long bone (HP:0003100)1.79037748
116Short middle phalanx of the 5th finger (HP:0004220)1.78971254
117Abnormality of DNA repair (HP:0003254)1.78924914
118Deep philtrum (HP:0002002)1.78851095
119Ovarian neoplasm (HP:0100615)1.77521000
120Septate vagina (HP:0001153)1.77360779
121Abnormality of the calcaneus (HP:0008364)1.77089680
122Clubbing of toes (HP:0100760)1.75342500
123Abnormality of pyrimidine metabolism (HP:0004353)1.75267534
124Lymphoma (HP:0002665)1.74904651
125Facial cleft (HP:0002006)1.72477068
126Microglossia (HP:0000171)1.68652509
127Abnormality of chromosome segregation (HP:0002916)1.67571337
128Reticulocytosis (HP:0001923)1.67373836
129Vaginal fistula (HP:0004320)1.66071892
130Type I transferrin isoform profile (HP:0003642)1.65721738
131Hypergonadotropic hypogonadism (HP:0000815)1.64859544
132Rectal fistula (HP:0100590)1.63369740
133Rectovaginal fistula (HP:0000143)1.63369740
134Combined immunodeficiency (HP:0005387)1.62519436
135Intestinal fistula (HP:0100819)1.61177865
136Hyperacusis (HP:0010780)1.60635671

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.37954046
2WEE14.67644200
3CDC74.04060081
4NEK23.48905076
5VRK23.02580398
6TTK2.97084532
7BRSK22.76980124
8EIF2AK12.70467687
9SMG12.67604908
10NEK12.56727411
11PLK12.37149052
12SRPK12.33430080
13PLK42.31784638
14CCNB12.21357222
15BRSK12.12062210
16TSSK61.96133001
17AURKB1.90769118
18PLK31.84773981
19TESK21.76056844
20STK161.66917076
21MKNK11.65962350
22CHEK21.64338573
23CDK71.63603981
24STK101.63592547
25ACVR1B1.63360711
26ATR1.57961037
27CDK121.56188010
28PASK1.55471168
29AURKA1.50018724
30NME21.49612129
31VRK11.49186825
32MAP3K81.47495618
33TLK11.45225428
34TRIB31.42263462
35EIF2AK31.34492031
36RPS6KB21.34279475
37STK41.33867582
38CDK41.33507075
39DYRK31.32448239
40MKNK21.31752120
41CHEK11.26981075
42TAF11.26402903
43EEF2K1.19828134
44RPS6KA41.18188626
45MAP3K101.18034130
46BCKDK1.09621485
47NME11.07098654
48EPHA21.05240941
49MELK1.01109513
50PAK41.00596063
51ZAK0.99312560
52* CDK20.86131273
53ATM0.84141572
54BRAF0.77991602
55EIF2AK20.76787673
56STK30.76692096
57AKT30.73525632
58ICK0.73047211
59PAK10.72900986
60TGFBR10.72211297
61* CDK10.71451494
62PIM10.67422607
63CLK10.65421931
64NUAK10.64604453
65CDK60.64298715
66ALK0.62664123
67BRD40.62427517
68TRIM280.61879393
69PRKCI0.59891521
70CSNK2A10.57721886
71CDK80.57572722
72PBK0.57040056
73SCYL20.55169507
74PNCK0.55143067
75CSNK2A20.54468308
76STK38L0.53521101
77LRRK20.52918005
78TESK10.45191889
79LATS20.44759486
80DAPK10.44456649
81CDK90.42767062
82MARK30.42284116
83IRAK30.41872889
84PRPF4B0.41199056
85AKT20.40955618
86PRKD30.38473955
87GRK60.38416044
88KDR0.37917417
89UHMK10.37029824
90RAF10.36638475
91RPS6KA50.34204314
92CDK190.33971663
93IRAK20.33714608
94MST1R0.33658636
95MAP4K10.33634999
96MTOR0.31009499
97PDK20.30333517
98PKN20.29181595
99CSNK1E0.28895567
100FLT30.28669559
101PRKDC0.28049533
102MST40.26560806
103MAP2K20.26307636
104MAPKAPK30.25426315
105CDK11A0.24870879
106PIM20.24608596
107CAMK1D0.23319246
108CDK150.23191654
109BMX0.23095621
110MAPK140.22574045
111CDK180.22080530
112PDK40.21277848
113PDK30.21277848
114DYRK20.17564488
115MAPK110.16723655
116CDK140.16568260
117MAPKAPK20.16404818
118AKT10.16108266
119CSNK1D0.15275512
120GSK3B0.14081375
121MAP3K110.13742647
122FGFR10.11581787
123YES10.11526744
124MAPK10.11292784

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.10144145
2Mismatch repair_Homo sapiens_hsa034304.41672520
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.67573700
4Spliceosome_Homo sapiens_hsa030403.43078655
5Cell cycle_Homo sapiens_hsa041103.34241923
6Homologous recombination_Homo sapiens_hsa034403.29125272
7RNA transport_Homo sapiens_hsa030133.27110645
8Base excision repair_Homo sapiens_hsa034103.26359753
9RNA polymerase_Homo sapiens_hsa030203.17057575
10Ribosome_Homo sapiens_hsa030102.97790997
11Nucleotide excision repair_Homo sapiens_hsa034202.94309662
12Proteasome_Homo sapiens_hsa030502.92376802
13Fanconi anemia pathway_Homo sapiens_hsa034602.48980719
14Pyrimidine metabolism_Homo sapiens_hsa002402.42746242
15One carbon pool by folate_Homo sapiens_hsa006702.42002939
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.39325022
17Non-homologous end-joining_Homo sapiens_hsa034502.09307540
18Basal transcription factors_Homo sapiens_hsa030221.96818263
19p53 signaling pathway_Homo sapiens_hsa041151.90848143
20RNA degradation_Homo sapiens_hsa030181.88707445
21mRNA surveillance pathway_Homo sapiens_hsa030151.83482371
22Vitamin B6 metabolism_Homo sapiens_hsa007501.72457138
23Oocyte meiosis_Homo sapiens_hsa041141.45668971
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33704812
25Purine metabolism_Homo sapiens_hsa002301.30904246
26Epstein-Barr virus infection_Homo sapiens_hsa051691.22495715
27Systemic lupus erythematosus_Homo sapiens_hsa053221.16839058
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11041643
29Pyruvate metabolism_Homo sapiens_hsa006201.07005053
30Viral carcinogenesis_Homo sapiens_hsa052030.99582779
31Pentose phosphate pathway_Homo sapiens_hsa000300.97358777
32Fatty acid elongation_Homo sapiens_hsa000620.91097250
33Biosynthesis of amino acids_Homo sapiens_hsa012300.90115057
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87567381
35Herpes simplex infection_Homo sapiens_hsa051680.85425694
36Cysteine and methionine metabolism_Homo sapiens_hsa002700.83706410
37Folate biosynthesis_Homo sapiens_hsa007900.83529849
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83088823
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81643303
40HTLV-I infection_Homo sapiens_hsa051660.80327972
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77046645
42Antigen processing and presentation_Homo sapiens_hsa046120.75682485
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.73849072
44MicroRNAs in cancer_Homo sapiens_hsa052060.73370193
45Steroid biosynthesis_Homo sapiens_hsa001000.71294358
46Selenocompound metabolism_Homo sapiens_hsa004500.67896424
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.61400276
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58656176
49Small cell lung cancer_Homo sapiens_hsa052220.57717509
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53971593
51Thyroid cancer_Homo sapiens_hsa052160.52318759
52Hippo signaling pathway_Homo sapiens_hsa043900.51471899
53Primary immunodeficiency_Homo sapiens_hsa053400.50409605
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48470033
55Carbon metabolism_Homo sapiens_hsa012000.47200490
56Basal cell carcinoma_Homo sapiens_hsa052170.47148978
57Glutathione metabolism_Homo sapiens_hsa004800.44964614
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44387713
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43937329
60Fructose and mannose metabolism_Homo sapiens_hsa000510.41218950
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41192620
62Sulfur relay system_Homo sapiens_hsa041220.39736083
63Alcoholism_Homo sapiens_hsa050340.39399121
64Huntingtons disease_Homo sapiens_hsa050160.39264585
65Apoptosis_Homo sapiens_hsa042100.39237131
66Fatty acid metabolism_Homo sapiens_hsa012120.37164585
67Colorectal cancer_Homo sapiens_hsa052100.36858932
68TGF-beta signaling pathway_Homo sapiens_hsa043500.36786452
69Pancreatic cancer_Homo sapiens_hsa052120.36612081
70Acute myeloid leukemia_Homo sapiens_hsa052210.36524846
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36102980
72Legionellosis_Homo sapiens_hsa051340.35633618
73Oxidative phosphorylation_Homo sapiens_hsa001900.35405943
74Hedgehog signaling pathway_Homo sapiens_hsa043400.35320317
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34128871
76Propanoate metabolism_Homo sapiens_hsa006400.33218582
77Bladder cancer_Homo sapiens_hsa052190.32583488
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31034372
79Hepatitis B_Homo sapiens_hsa051610.29813281
80Notch signaling pathway_Homo sapiens_hsa043300.29721186
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27799857
82Protein export_Homo sapiens_hsa030600.27717939
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27615028
84Arginine and proline metabolism_Homo sapiens_hsa003300.27184076
85HIF-1 signaling pathway_Homo sapiens_hsa040660.25982396
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25555389
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25163043
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23162139
89Pathways in cancer_Homo sapiens_hsa052000.22571084
90Chronic myeloid leukemia_Homo sapiens_hsa052200.22532838
91Galactose metabolism_Homo sapiens_hsa000520.21953651
92mTOR signaling pathway_Homo sapiens_hsa041500.20108439
93Regulation of autophagy_Homo sapiens_hsa041400.19810569
94Measles_Homo sapiens_hsa051620.18562420
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.18261206
96N-Glycan biosynthesis_Homo sapiens_hsa005100.18193669
97FoxO signaling pathway_Homo sapiens_hsa040680.17981848
98Endometrial cancer_Homo sapiens_hsa052130.16711718
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16523246
100Renin-angiotensin system_Homo sapiens_hsa046140.16293379
101Shigellosis_Homo sapiens_hsa051310.15135297
102Prostate cancer_Homo sapiens_hsa052150.15099376
103Metabolic pathways_Homo sapiens_hsa011000.14900685
104Arginine biosynthesis_Homo sapiens_hsa002200.13249054
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13171278
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12873427
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.12060663
108Alzheimers disease_Homo sapiens_hsa050100.12032673
109Influenza A_Homo sapiens_hsa051640.11835680
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.11322444
111Non-small cell lung cancer_Homo sapiens_hsa052230.11308939
112Adherens junction_Homo sapiens_hsa045200.11045565
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.10954469
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08885691
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.08653648
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.08441898
117Parkinsons disease_Homo sapiens_hsa050120.08260247
118Wnt signaling pathway_Homo sapiens_hsa043100.07413072
119Viral myocarditis_Homo sapiens_hsa054160.06461212
120Lysine degradation_Homo sapiens_hsa003100.06129216

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