KIAA1755

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.25143760
2central nervous system myelination (GO:0022010)6.25143760
3synaptic vesicle docking involved in exocytosis (GO:0016081)4.94046261
4membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.44356119
5postsynaptic membrane organization (GO:0001941)4.27878067
6glutamate secretion (GO:0014047)3.87740511
7dermatan sulfate biosynthetic process (GO:0030208)3.84334349
8dermatan sulfate metabolic process (GO:0030205)3.78116125
9synaptic vesicle maturation (GO:0016188)3.59342439
10negative regulation of synaptic transmission, GABAergic (GO:0032229)3.57388310
11locomotory exploration behavior (GO:0035641)3.51315515
12cellular potassium ion homeostasis (GO:0030007)3.49928213
13regulation of short-term neuronal synaptic plasticity (GO:0048172)3.49118445
14neuronal ion channel clustering (GO:0045161)3.42056003
15neuron cell-cell adhesion (GO:0007158)3.34533418
16presynaptic membrane organization (GO:0097090)3.28900762
17synaptic vesicle exocytosis (GO:0016079)3.28760406
18dendritic spine morphogenesis (GO:0060997)3.28450866
19peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.28361080
20vocalization behavior (GO:0071625)3.27730629
21presynaptic membrane assembly (GO:0097105)3.27338843
22chondroitin sulfate catabolic process (GO:0030207)3.20159899
23L-amino acid import (GO:0043092)3.19213771
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.18392721
25astrocyte development (GO:0014002)3.15788855
26gamma-aminobutyric acid transport (GO:0015812)3.04874717
27transmission of nerve impulse (GO:0019226)2.98777134
28neuronal action potential propagation (GO:0019227)2.93614886
29astrocyte differentiation (GO:0048708)2.91683234
30sodium ion export (GO:0071436)2.91122504
31ionotropic glutamate receptor signaling pathway (GO:0035235)2.89879707
32regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88878004
33response to gravity (GO:0009629)2.87039093
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.84739131
35potassium ion import (GO:0010107)2.84328378
36protein heterotrimerization (GO:0070208)2.83143171
37axon ensheathment (GO:0008366)2.82739265
38ensheathment of neurons (GO:0007272)2.82739265
39myelin maintenance (GO:0043217)2.82696334
40regulation of neuronal synaptic plasticity (GO:0048168)2.82351195
41neurotransmitter-gated ion channel clustering (GO:0072578)2.81030079
42negative regulation of axonogenesis (GO:0050771)2.78259556
43amino acid import (GO:0043090)2.77435520
44myelination (GO:0042552)2.77076154
45potassium ion homeostasis (GO:0055075)2.76096308
46membrane depolarization during action potential (GO:0086010)2.74925945
47exploration behavior (GO:0035640)2.73049722
48synaptic transmission, glutamatergic (GO:0035249)2.67956243
49regulation of neurotransmitter uptake (GO:0051580)2.67499710
50axonal fasciculation (GO:0007413)2.63477563
51positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.62785383
52neurotransmitter secretion (GO:0007269)2.62544038
53regulation of synapse structural plasticity (GO:0051823)2.60865100
54cerebellar granule cell differentiation (GO:0021707)2.60005093
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.58668500
56positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.57843927
57auditory behavior (GO:0031223)2.57154460
58regulation of synaptic vesicle exocytosis (GO:2000300)2.54627692
59urinary tract smooth muscle contraction (GO:0014848)2.53962471
60regulation of respiratory system process (GO:0044065)2.53764118
61protein localization to synapse (GO:0035418)2.49481893
62regulation of long-term neuronal synaptic plasticity (GO:0048169)2.46285985
63dendritic spine organization (GO:0097061)2.45848992
64cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.45457695
65proline transport (GO:0015824)2.44262153
66glutamate receptor signaling pathway (GO:0007215)2.43838149
67regulation of excitatory postsynaptic membrane potential (GO:0060079)2.43213425
68positive regulation of dendritic spine development (GO:0060999)2.42324548
69regulation of neurotransmitter transport (GO:0051588)2.41863545
70neuron recognition (GO:0008038)2.41635208
71gamma-aminobutyric acid signaling pathway (GO:0007214)2.40554106
72positive regulation of synapse assembly (GO:0051965)2.39078694
73positive regulation of synapse maturation (GO:0090129)2.38343081
74regulation of postsynaptic membrane potential (GO:0060078)2.37430641
75membrane depolarization (GO:0051899)2.36376726
76acidic amino acid transport (GO:0015800)2.36009242
77extracellular matrix assembly (GO:0085029)2.34881590
78regulation of voltage-gated calcium channel activity (GO:1901385)2.34671500
79regulation of synaptic vesicle transport (GO:1902803)2.34117525
80myelination in peripheral nervous system (GO:0022011)2.34077616
81peripheral nervous system axon ensheathment (GO:0032292)2.34077616
82regulation of dendritic spine development (GO:0060998)2.31638495
83neuron-neuron synaptic transmission (GO:0007270)2.30974177
84long-term synaptic potentiation (GO:0060291)2.28222966
85behavioral response to nicotine (GO:0035095)2.27891783
86regulation of synaptic transmission, glutamatergic (GO:0051966)2.27872552
87regulation of neurotransmitter secretion (GO:0046928)2.27342054
88regulation of female receptivity (GO:0045924)2.27086749
89regulation of glutamate receptor signaling pathway (GO:1900449)2.25500761
90regulation of synaptic plasticity (GO:0048167)2.24864833
91dendrite morphogenesis (GO:0048813)2.23197265
92neurotransmitter uptake (GO:0001504)2.23083912
93C4-dicarboxylate transport (GO:0015740)2.22742477
94neurotransmitter transport (GO:0006836)2.21769003
95negative regulation of cytosolic calcium ion concentration (GO:0051481)2.21101848
96negative regulation of axon extension (GO:0030517)2.19556699
97positive regulation of dendrite development (GO:1900006)2.19541678
98chondrocyte proliferation (GO:0035988)2.18839567
99peristalsis (GO:0030432)2.16433397
100neuromuscular synaptic transmission (GO:0007274)2.16379854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.11569201
2DROSHA_22980978_ChIP-Seq_HELA_Human2.69699793
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61984039
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56412083
5GBX2_23144817_ChIP-Seq_PC3_Human2.32926313
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27995755
7SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26847210
8RNF2_27304074_Chip-Seq_ESCs_Mouse2.24362393
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.23363254
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22819074
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.19109407
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.18688729
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15402145
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15402145
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12614662
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09886452
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.08277107
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.06122751
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04906193
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.97192299
21REST_21632747_ChIP-Seq_MESCs_Mouse1.96239401
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94366222
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80113357
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77711175
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76345278
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62136132
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.58932639
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52476773
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49251301
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48844172
31AR_21572438_ChIP-Seq_LNCaP_Human1.46634029
32WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38852013
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38441379
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37882524
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.37376189
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37257858
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33830253
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.33678619
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30400886
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28904497
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.27977678
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27682973
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.27654066
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25701192
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.22590000
46TP53_16413492_ChIP-PET_HCT116_Human1.22585408
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21509156
48SMAD4_21799915_ChIP-Seq_A2780_Human1.20749351
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20187881
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18820776
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18497850
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.16533703
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11517334
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10198280
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09961764
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09650125
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.07126541
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03598295
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.03355384
60MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02856332
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02630961
62STAT3_23295773_ChIP-Seq_U87_Human1.02616090
63* SMAD3_21741376_ChIP-Seq_EPCs_Human1.01432884
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01381593
65TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99834276
66NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99626589
67AR_19668381_ChIP-Seq_PC3_Human0.99601435
68EP300_21415370_ChIP-Seq_HL-1_Mouse0.99423357
69PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99137662
70CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97788524
71RING1B_27294783_Chip-Seq_NPCs_Mouse0.96889970
72* TCF4_23295773_ChIP-Seq_U87_Human0.96560897
73NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96497633
74TP53_23651856_ChIP-Seq_MEFs_Mouse0.95920654
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95732820
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95570050
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95364425
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94284903
79* CJUN_26792858_Chip-Seq_BT549_Human0.92687719
80CTCF_27219007_Chip-Seq_Bcells_Human0.92362997
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92136232
82TP53_18474530_ChIP-ChIP_U2OS_Human0.92010905
83PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91522267
84TP53_20018659_ChIP-ChIP_R1E_Mouse0.90249678
85RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90021968
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89826193
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89826193
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89818028
89AR_25329375_ChIP-Seq_VCAP_Human0.89433201
90OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89354712
91* SMAD3_21741376_ChIP-Seq_ESCs_Human0.88880287
92CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88856124
93DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88833365
94AHR_22903824_ChIP-Seq_MCF-7_Human0.88781390
95SMAD4_21741376_ChIP-Seq_HESCs_Human0.86276681
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85763238
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85260114
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85162390
99KDM2B_26808549_Chip-Seq_REH_Human0.84113715
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84071662

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.72320172
2MP0005503_abnormal_tendon_morphology3.26225847
3MP0008438_abnormal_cutaneous_collagen3.12323693
4MP0001958_emphysema2.73997152
5MP0003635_abnormal_synaptic_transmissio2.69207488
6MP0003880_abnormal_central_pattern2.63261324
7MP0002064_seizures2.58093908
8MP0004270_analgesia2.56353025
9MP0001486_abnormal_startle_reflex2.53453055
10MP0002272_abnormal_nervous_system2.38289774
11MP0009745_abnormal_behavioral_response2.37891970
12MP0004885_abnormal_endolymph2.24207454
13MP0001968_abnormal_touch/_nociception2.21189375
14MP0002063_abnormal_learning/memory/cond2.16722428
15MP0005423_abnormal_somatic_nervous2.06792539
16MP0003279_aneurysm2.06083601
17MP0000920_abnormal_myelination2.01768547
18MP0002572_abnormal_emotion/affect_behav1.99223152
19MP0001501_abnormal_sleep_pattern1.96026237
20MP0002734_abnormal_mechanical_nocicepti1.94884005
21MP0002735_abnormal_chemical_nociception1.94004247
22MP0009780_abnormal_chondrocyte_physiolo1.93173136
23MP0005171_absent_coat_pigmentation1.92323598
24MP0000569_abnormal_digit_pigmentation1.89167272
25MP0001970_abnormal_pain_threshold1.79249388
26MP0009046_muscle_twitch1.77845022
27MP0003690_abnormal_glial_cell1.75038690
28MP0001502_abnormal_circadian_rhythm1.74316567
29MP0003329_amyloid_beta_deposits1.70947082
30MP0000778_abnormal_nervous_system1.67604672
31MP0005275_abnormal_skin_tensile1.67524435
32MP0002733_abnormal_thermal_nociception1.65713772
33MP0001905_abnormal_dopamine_level1.63544241
34MP0003283_abnormal_digestive_organ1.59060746
35MP0002736_abnormal_nociception_after1.57307325
36MP0008569_lethality_at_weaning1.56393561
37MP0003879_abnormal_hair_cell1.54371946
38MP0005167_abnormal_blood-brain_barrier1.52605009
39MP0000751_myopathy1.46861672
40MP0003633_abnormal_nervous_system1.45510274
41MP0005551_abnormal_eye_electrophysiolog1.42515822
42MP0001348_abnormal_lacrimal_gland1.41912307
43MP0005646_abnormal_pituitary_gland1.36089027
44MP0002067_abnormal_sensory_capabilities1.32371163
45MP0001984_abnormal_olfaction1.29747663
46MP0002557_abnormal_social/conspecific_i1.29291751
47MP0009384_cardiac_valve_regurgitation1.27388305
48MP0010386_abnormal_urinary_bladder1.25222704
49MP0004858_abnormal_nervous_system1.25002440
50MP0003634_abnormal_glial_cell1.24206610
51MP0003136_yellow_coat_color1.23807950
52MP0001299_abnormal_eye_distance/1.19813527
53MP0006276_abnormal_autonomic_nervous1.19327038
54MP0005508_abnormal_skeleton_morphology1.19313643
55MP0003631_nervous_system_phenotype1.18590438
56MP0002882_abnormal_neuron_morphology1.17158351
57MP0003632_abnormal_nervous_system1.17134281
58MP0004142_abnormal_muscle_tone1.15437505
59MP0001485_abnormal_pinna_reflex1.13997783
60MP0000955_abnormal_spinal_cord1.10420168
61MP0005595_abnormal_vascular_smooth1.08047261
62MP0002066_abnormal_motor_capabilities/c1.07741728
63MP0002108_abnormal_muscle_morphology1.07578807
64MP0005386_behavior/neurological_phenoty1.05691059
65MP0004924_abnormal_behavior1.05691059
66MP0004742_abnormal_vestibular_system1.02899117
67MP0010368_abnormal_lymphatic_system1.01378764
68MP0003045_fibrosis0.98446157
69MP0001963_abnormal_hearing_physiology0.98386675
70MP0000026_abnormal_inner_ear0.97285889
71MP0002249_abnormal_larynx_morphology0.96705202
72MP0005623_abnormal_meninges_morphology0.95877294
73MP0000013_abnormal_adipose_tissue0.92721441
74MP0001440_abnormal_grooming_behavior0.92435879
75MP0002653_abnormal_ependyma_morphology0.92395714
76MP0001177_atelectasis0.90691576
77MP0002184_abnormal_innervation0.90025951
78MP0001986_abnormal_taste_sensitivity0.89686072
79MP0003950_abnormal_plasma_membrane0.87753384
80MP0002295_abnormal_pulmonary_circulatio0.87287617
81MP0002229_neurodegeneration0.86960404
82MP0004811_abnormal_neuron_physiology0.85402799
83MP0002933_joint_inflammation0.82637217
84MP0002752_abnormal_somatic_nervous0.81652989
85MP0004215_abnormal_myocardial_fiber0.80642273
86MP0000749_muscle_degeneration0.76502390
87MP0000767_abnormal_smooth_muscle0.75620240
88MP0010030_abnormal_orbit_morphology0.74871495
89MP0002638_abnormal_pupillary_reflex0.73909094
90MP0005670_abnormal_white_adipose0.73770787
91MP0002152_abnormal_brain_morphology0.73253616
92MP0002932_abnormal_joint_morphology0.72980998
93MP0005253_abnormal_eye_physiology0.72104828
94MP0000049_abnormal_middle_ear0.69858980
95MP0004043_abnormal_pH_regulation0.69705358
96MP0004272_abnormal_basement_membrane0.68964990
97MP0000462_abnormal_digestive_system0.68717779
98MP0002089_abnormal_postnatal_growth/wei0.67620588
99MP0003705_abnormal_hypodermis_morpholog0.67398734
100MP0000534_abnormal_ureter_morphology0.67207553

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)3.57860601
2Protrusio acetabuli (HP:0003179)3.48374246
3Action tremor (HP:0002345)3.48298978
4Focal seizures (HP:0007359)3.45012074
5Focal motor seizures (HP:0011153)3.38381382
6Broad metatarsal (HP:0001783)3.31642928
7Obstructive sleep apnea (HP:0002870)3.28476984
8Shallow orbits (HP:0000586)3.23316320
9Myokymia (HP:0002411)3.08397480
10Aortic dissection (HP:0002647)2.97830053
11Bladder diverticulum (HP:0000015)2.89572824
12Progressive cerebellar ataxia (HP:0002073)2.87330970
13Abnormality of dentin (HP:0010299)2.79158324
14Neonatal short-limb short stature (HP:0008921)2.76206318
15Diplopia (HP:0000651)2.76053926
16Abnormality of binocular vision (HP:0011514)2.76053926
17Aortic aneurysm (HP:0004942)2.72928110
18Neurofibrillary tangles (HP:0002185)2.72556283
19Increased corneal curvature (HP:0100692)2.70823046
20Keratoconus (HP:0000563)2.70823046
21Follicular hyperkeratosis (HP:0007502)2.65225362
22Hyperventilation (HP:0002883)2.52531433
23Mild short stature (HP:0003502)2.51600348
24Epileptic encephalopathy (HP:0200134)2.44413897
25Atonic seizures (HP:0010819)2.43736205
26Soft skin (HP:0000977)2.43190031
27Torticollis (HP:0000473)2.41110189
28Febrile seizures (HP:0002373)2.40773542
29Metabolic alkalosis (HP:0200114)2.39584306
30Ankle clonus (HP:0011448)2.35985180
31Bowel diverticulosis (HP:0005222)2.34753244
32Infantile muscular hypotonia (HP:0008947)2.31528508
33Abnormal eating behavior (HP:0100738)2.30573313
34Ankle contracture (HP:0006466)2.28878999
35Hemiparesis (HP:0001269)2.21227866
36Absent speech (HP:0001344)2.19255677
37Limited hip movement (HP:0008800)2.17033677
38Aortic valve stenosis (HP:0001650)2.15755425
39Mesangial abnormality (HP:0001966)2.15686353
40Genetic anticipation (HP:0003743)2.13032528
41Bronchomalacia (HP:0002780)2.11560938
42Increased circulating renin level (HP:0000848)2.09779396
43Hemiplegia (HP:0002301)2.09053537
44Wrist flexion contracture (HP:0001239)2.07417363
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.07195993
46Degeneration of the lateral corticospinal tracts (HP:0002314)2.07195993
47Pulmonary artery stenosis (HP:0004415)2.06024356
48Megalencephaly (HP:0001355)2.04583184
49Atrophic scars (HP:0001075)2.03386292
50Sleep apnea (HP:0010535)2.00032590
51Hypoplasia of the iris (HP:0007676)1.99829764
52Type 1 muscle fiber predominance (HP:0003803)1.99545859
53Wide anterior fontanel (HP:0000260)1.97324536
54Hypoventilation (HP:0002791)1.97084313
55Prolonged QT interval (HP:0001657)1.96526101
56Limb dystonia (HP:0002451)1.96402628
57Renal duplication (HP:0000075)1.95987012
58Vitreoretinal degeneration (HP:0000655)1.95877982
59Aortic regurgitation (HP:0001659)1.94316716
60Round ear (HP:0100830)1.94230352
61Supranuclear gaze palsy (HP:0000605)1.93867478
62Spastic gait (HP:0002064)1.93362513
63Papilledema (HP:0001085)1.93293229
64Urinary bladder sphincter dysfunction (HP:0002839)1.89440292
65Cerebral aneurysm (HP:0004944)1.89439794
66Synostosis of carpal bones (HP:0005048)1.89281319
67Abnormality of the corticospinal tract (HP:0002492)1.85860636
68Overgrowth (HP:0001548)1.83757598
69Scanning speech (HP:0002168)1.83145160
70Hyperextensible skin (HP:0000974)1.82411514
71Cerebral inclusion bodies (HP:0100314)1.82183204
72Fragile skin (HP:0001030)1.82141773
73Abnormality of incisor morphology (HP:0011063)1.78778009
74Abnormal drinking behavior (HP:0030082)1.78424652
75Polydipsia (HP:0001959)1.78424652
76Peripheral hypomyelination (HP:0007182)1.77802423
77Flat cornea (HP:0007720)1.77456213
78Gaze-evoked nystagmus (HP:0000640)1.76763448
79Congenital stationary night blindness (HP:0007642)1.75329571
80Genu recurvatum (HP:0002816)1.74198116
81Mitral regurgitation (HP:0001653)1.74153368
82Focal dystonia (HP:0004373)1.73648794
83Blue sclerae (HP:0000592)1.72948299
84Biconcave vertebral bodies (HP:0004586)1.71130923
85Nephronophthisis (HP:0000090)1.71075628
86Hip contracture (HP:0003273)1.70074597
87Generalized tonic-clonic seizures (HP:0002069)1.69557045
88Craniofacial dystonia (HP:0012179)1.67705494
89Vascular tortuosity (HP:0004948)1.67130948
90Spondylolisthesis (HP:0003302)1.66188492
91Turricephaly (HP:0000262)1.65735195
92Hypoplastic ischia (HP:0003175)1.65411448
93Bundle branch block (HP:0011710)1.64154332
94Spinal canal stenosis (HP:0003416)1.63245948
95Bradycardia (HP:0001662)1.62347954
96Akinesia (HP:0002304)1.62204306
97Joint stiffness (HP:0001387)1.60650510
98Stridor (HP:0010307)1.60541539
99Dialeptic seizures (HP:0011146)1.60365066
100Dysmetria (HP:0001310)1.59847367

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.07198282
2EPHA43.49027660
3MARK13.38940825
4FRK2.79102927
5PAK62.46744302
6CASK2.37363375
7NTRK22.23068453
8DAPK22.22740726
9MYLK2.13990132
10NTRK11.91022309
11PAK31.81041856
12UHMK11.79950672
13DDR21.75966884
14PHKG21.68763192
15PHKG11.68763192
16PTK2B1.65125622
17ADRBK21.63604848
18EPHB21.63549466
19INSRR1.56353920
20LMTK21.54633073
21PRKD31.47140779
22PKN11.43978554
23TNK21.40610896
24FGFR21.37423973
25PLK21.36671019
26SGK4941.33664092
27SGK2231.33664092
28CAMK11.29819404
29CAMK2B1.29500045
30SGK21.28356389
31PINK11.27881750
32MINK11.26502596
33MET1.25374637
34TYRO31.16939485
35PDGFRA1.15675557
36MAPK131.13829645
37STK381.13636905
38GRK11.13560190
39CAMK2G1.12926865
40ROCK11.10798173
41PRKCG1.07422640
42SIK21.06751538
43STK38L1.04793874
44LIMK11.00508948
45CDK50.97873282
46GRK50.97248524
47CAMKK10.96910554
48MARK20.96329699
49PTK20.95943099
50CAMK2A0.95012108
51ROCK20.94195587
52RIPK10.92535296
53MAP3K70.90487371
54CAMK2D0.89805366
55PDGFRB0.89373676
56OXSR10.86541648
57PRKCH0.84136608
58SGK30.83150074
59ERBB20.83090006
60PRKD20.79502563
61CDC42BPA0.78828353
62PNCK0.77210648
63DMPK0.76643261
64PRKCE0.76498556
65TESK10.74328021
66PAK20.73158338
67KSR10.72058250
68WNK30.72046499
69ADRBK10.71547837
70SGK10.70739450
71KIT0.70257501
72PRKG20.69468284
73LATS10.68123935
74MAPK70.65459239
75DAPK30.65130565
76PRKG10.63552321
77PRKCZ0.63457986
78PIK3CG0.62611430
79MAPKAPK50.61927708
80STK110.61517512
81RPS6KA20.60853806
82MAP2K60.59515648
83DYRK1A0.58848742
84MAPK100.58467365
85PIK3CA0.58043682
86STK390.56648215
87ABL20.56433014
88PRKD10.55036416
89MAP3K130.54120293
90MUSK0.54042436
91WNK40.52069630
92WNK10.51657421
93RPS6KA30.51029191
94MAP3K20.45863759
95CAMKK20.44082482
96CAMK40.43949392
97KSR20.43008504
98PRKACA0.42708859
99MAP2K10.41901263
100BMX0.41712872

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.66949182
2Insulin secretion_Homo sapiens_hsa049112.59004416
3Circadian entrainment_Homo sapiens_hsa047132.49574480
4Morphine addiction_Homo sapiens_hsa050322.26364637
5Glutamatergic synapse_Homo sapiens_hsa047242.24559251
6GABAergic synapse_Homo sapiens_hsa047272.19755332
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.14112310
8Amphetamine addiction_Homo sapiens_hsa050312.12500798
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10096974
10Synaptic vesicle cycle_Homo sapiens_hsa047212.06389803
11Cocaine addiction_Homo sapiens_hsa050301.95625619
12Gastric acid secretion_Homo sapiens_hsa049711.84936754
13Dopaminergic synapse_Homo sapiens_hsa047281.84627904
14Salivary secretion_Homo sapiens_hsa049701.79367109
15ECM-receptor interaction_Homo sapiens_hsa045121.78367783
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74985326
17Vascular smooth muscle contraction_Homo sapiens_hsa042701.66299790
18Renin secretion_Homo sapiens_hsa049241.62003081
19Cholinergic synapse_Homo sapiens_hsa047251.61839973
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61054711
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57315189
22Histidine metabolism_Homo sapiens_hsa003401.56568348
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54524755
24Protein digestion and absorption_Homo sapiens_hsa049741.52451100
25cAMP signaling pathway_Homo sapiens_hsa040241.48625570
26Calcium signaling pathway_Homo sapiens_hsa040201.47564033
27Taste transduction_Homo sapiens_hsa047421.45101885
28Long-term potentiation_Homo sapiens_hsa047201.43883789
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39727641
30Oxytocin signaling pathway_Homo sapiens_hsa049211.37341878
31Dilated cardiomyopathy_Homo sapiens_hsa054141.31797089
32Serotonergic synapse_Homo sapiens_hsa047261.29469947
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24102630
34Axon guidance_Homo sapiens_hsa043601.20322273
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18791006
36Long-term depression_Homo sapiens_hsa047301.16836679
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16191898
38Phototransduction_Homo sapiens_hsa047441.12469750
39Bile secretion_Homo sapiens_hsa049761.06950071
40Dorso-ventral axis formation_Homo sapiens_hsa043201.06146698
41Olfactory transduction_Homo sapiens_hsa047401.04312053
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03566368
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.03264076
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03138387
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01173645
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00490210
47Pancreatic secretion_Homo sapiens_hsa049721.00202418
48Focal adhesion_Homo sapiens_hsa045100.99131118
49Estrogen signaling pathway_Homo sapiens_hsa049150.97192508
50Ether lipid metabolism_Homo sapiens_hsa005650.97151724
51Melanogenesis_Homo sapiens_hsa049160.96973586
52Circadian rhythm_Homo sapiens_hsa047100.96182830
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93979952
54Thyroid hormone synthesis_Homo sapiens_hsa049180.93029735
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92597921
56Vitamin B6 metabolism_Homo sapiens_hsa007500.91165662
57Linoleic acid metabolism_Homo sapiens_hsa005910.88529531
58ABC transporters_Homo sapiens_hsa020100.87468295
59Ras signaling pathway_Homo sapiens_hsa040140.86841509
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83829158
61Gap junction_Homo sapiens_hsa045400.83042437
62GnRH signaling pathway_Homo sapiens_hsa049120.81479885
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79098711
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75956017
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.75420487
66Nitrogen metabolism_Homo sapiens_hsa009100.72642383
67beta-Alanine metabolism_Homo sapiens_hsa004100.71372321
68Rap1 signaling pathway_Homo sapiens_hsa040150.70123903
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69501253
70Ovarian steroidogenesis_Homo sapiens_hsa049130.68803260
71MAPK signaling pathway_Homo sapiens_hsa040100.67987517
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.67754742
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67452877
74Cardiac muscle contraction_Homo sapiens_hsa042600.67059594
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67054410
76Arginine and proline metabolism_Homo sapiens_hsa003300.66973356
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65882613
78Tight junction_Homo sapiens_hsa045300.63686590
79Mineral absorption_Homo sapiens_hsa049780.63265256
80Hippo signaling pathway_Homo sapiens_hsa043900.62169373
81Notch signaling pathway_Homo sapiens_hsa043300.61328317
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59146406
83Glioma_Homo sapiens_hsa052140.54148233
84Glycerolipid metabolism_Homo sapiens_hsa005610.51361313
85Arachidonic acid metabolism_Homo sapiens_hsa005900.50992335
86Amoebiasis_Homo sapiens_hsa051460.48002104
87Hedgehog signaling pathway_Homo sapiens_hsa043400.47351286
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47199152
89Choline metabolism in cancer_Homo sapiens_hsa052310.47092076
90Collecting duct acid secretion_Homo sapiens_hsa049660.44094738
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43298620
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41890109
93Prion diseases_Homo sapiens_hsa050200.38834136
94Glucagon signaling pathway_Homo sapiens_hsa049220.38461904
95Wnt signaling pathway_Homo sapiens_hsa043100.37429603
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.37229058
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.35419176
98Inositol phosphate metabolism_Homo sapiens_hsa005620.34334786
99VEGF signaling pathway_Homo sapiens_hsa043700.33123628
100Butanoate metabolism_Homo sapiens_hsa006500.32778797

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