KIAA1683

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)4.71091571
2positive regulation of protein kinase C signaling (GO:0090037)4.30208000
3cilium or flagellum-dependent cell motility (GO:0001539)4.10359685
4behavioral response to nicotine (GO:0035095)4.00891501
5negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.87185670
6negative regulation of translation, ncRNA-mediated (GO:0040033)3.87185670
7regulation of translation, ncRNA-mediated (GO:0045974)3.87185670
8urinary tract smooth muscle contraction (GO:0014848)3.68010309
9axoneme assembly (GO:0035082)3.66809336
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.60524861
11detection of light stimulus involved in visual perception (GO:0050908)3.49443433
12detection of light stimulus involved in sensory perception (GO:0050962)3.49443433
13nephron epithelium morphogenesis (GO:0072088)3.39187761
14nephron tubule morphogenesis (GO:0072078)3.39187761
15positive regulation of CREB transcription factor activity (GO:0032793)3.21843657
16establishment of protein localization to Golgi (GO:0072600)3.12496541
17cilium movement (GO:0003341)3.05783695
18epithelial cilium movement (GO:0003351)3.05192047
19peptidyl-lysine trimethylation (GO:0018023)2.99148708
20regulation of cilium movement (GO:0003352)2.96877114
21axonemal dynein complex assembly (GO:0070286)2.90700094
22histone H3-K4 methylation (GO:0051568)2.81006884
23peptidyl-lysine methylation (GO:0018022)2.80016425
24regulation of microtubule-based movement (GO:0060632)2.78061084
25regulation of cytokine production involved in inflammatory response (GO:1900015)2.75908096
26interkinetic nuclear migration (GO:0022027)2.72291320
27positive regulation of histone deacetylation (GO:0031065)2.70781884
28negative regulation of telomere maintenance (GO:0032205)2.69855966
29negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.69837063
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.64646360
31regulation of synapse structural plasticity (GO:0051823)2.63559874
32sperm motility (GO:0030317)2.62788307
33protein targeting to Golgi (GO:0000042)2.61685167
34mitotic cell cycle arrest (GO:0071850)2.59364974
35sex determination (GO:0007530)2.58659795
36protein localization to Golgi apparatus (GO:0034067)2.58347095
37renal tubule morphogenesis (GO:0061333)2.57844773
38histone H3-K9 modification (GO:0061647)2.57612792
39retrograde transport, vesicle recycling within Golgi (GO:0000301)2.57509558
40histone H3-K9 methylation (GO:0051567)2.57071468
41protein polyglutamylation (GO:0018095)2.56540367
42fucose catabolic process (GO:0019317)2.55901202
43L-fucose metabolic process (GO:0042354)2.55901202
44L-fucose catabolic process (GO:0042355)2.55901202
45glycerophospholipid catabolic process (GO:0046475)2.55470577
46cellular response to ATP (GO:0071318)2.54762919
47cAMP catabolic process (GO:0006198)2.51700986
48spinal cord motor neuron differentiation (GO:0021522)2.48929742
49negative regulation of Rho protein signal transduction (GO:0035024)2.46367967
50macroautophagy (GO:0016236)2.46118242
51cellular response to exogenous dsRNA (GO:0071360)2.45580748
52RNA destabilization (GO:0050779)2.44275491
53activated T cell proliferation (GO:0050798)2.43749116
54regulation of protein kinase C signaling (GO:0090036)2.42486382
55dendritic spine morphogenesis (GO:0060997)2.42221658
56alanine transport (GO:0032328)2.41924165
57membrane depolarization during action potential (GO:0086010)2.40545635
58tryptophan catabolic process (GO:0006569)2.40446587
59indole-containing compound catabolic process (GO:0042436)2.40446587
60indolalkylamine catabolic process (GO:0046218)2.40446587
61alkaloid metabolic process (GO:0009820)2.39634684
62multicellular organism reproduction (GO:0032504)2.39334051
63neuron maturation (GO:0042551)2.38294513
64protein K11-linked deubiquitination (GO:0035871)2.38245535
65reflex (GO:0060004)2.36043512
66motile cilium assembly (GO:0044458)2.35393858
67drug catabolic process (GO:0042737)2.32891229
68positive regulation of defense response to virus by host (GO:0002230)2.32231329
69positive regulation of fatty acid oxidation (GO:0046321)2.31619050
70auditory behavior (GO:0031223)2.31129059
71negative regulation of interleukin-8 production (GO:0032717)2.30764026
72urogenital system development (GO:0001655)2.29507574
73response to pheromone (GO:0019236)2.28941274
74regulation of Rab GTPase activity (GO:0032313)2.28347960
75positive regulation of Rab GTPase activity (GO:0032851)2.28347960
76regulation of telomere maintenance (GO:0032204)2.26179875
77histone lysine methylation (GO:0034968)2.25948606
78phosphatidylethanolamine biosynthetic process (GO:0006646)2.25888498
79protein localization to cilium (GO:0061512)2.25657345
80cilium organization (GO:0044782)2.24696229
81negative regulation of cAMP-mediated signaling (GO:0043951)2.24271896
82head development (GO:0060322)2.23161396
83startle response (GO:0001964)2.22821051
84phosphatidylglycerol biosynthetic process (GO:0006655)2.22665382
85positive regulation of triglyceride biosynthetic process (GO:0010867)2.21254232
86cyclic nucleotide catabolic process (GO:0009214)2.20654080
87cilium assembly (GO:0042384)2.19750886
88embryonic hemopoiesis (GO:0035162)2.19708774
89positive regulation of fatty acid beta-oxidation (GO:0032000)2.18899388
90indolalkylamine metabolic process (GO:0006586)2.18854906
91phosphatidylethanolamine metabolic process (GO:0046337)2.18614239
92sulfation (GO:0051923)2.17515627
93detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.16606017
94positive regulation by host of viral transcription (GO:0043923)2.16211681
95regulation of action potential (GO:0098900)2.13791479
96regulation of hydrogen peroxide metabolic process (GO:0010310)2.13644572
97cilium morphogenesis (GO:0060271)2.13251731
98phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.12384374
99positive regulation of protein deacetylation (GO:0090312)2.12068395
100regulation of skeletal muscle contraction (GO:0014819)2.11094388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.36118526
2DROSHA_22980978_ChIP-Seq_HELA_Human3.29295330
3CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.28192366
4ZNF274_21170338_ChIP-Seq_K562_Hela2.07804202
5IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04688662
6VDR_22108803_ChIP-Seq_LS180_Human1.80041262
7REST_21632747_ChIP-Seq_MESCs_Mouse1.75117875
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74348215
9EZH2_27294783_Chip-Seq_ESCs_Mouse1.73633526
10GBX2_23144817_ChIP-Seq_PC3_Human1.71274829
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70603352
12STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69715594
13SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66724011
14AR_21572438_ChIP-Seq_LNCaP_Human1.57909212
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56592290
16ERA_21632823_ChIP-Seq_H3396_Human1.52045381
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51315008
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41110699
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41064913
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38531690
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.36324877
22P68_20966046_ChIP-Seq_HELA_Human1.35958625
23* CTCF_27219007_Chip-Seq_Bcells_Human1.35630923
24POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35515026
25TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35515026
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.29920807
27* E2F1_20622854_ChIP-Seq_HELA_Human1.29219077
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27718310
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26465321
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.26307072
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.22190590
32PHF8_20622854_ChIP-Seq_HELA_Human1.22083681
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.21522641
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20670814
35ER_23166858_ChIP-Seq_MCF-7_Human1.19872333
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.19694382
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.19072426
38OCT4_20526341_ChIP-Seq_ESCs_Human1.18693589
39OCT4_19829295_ChIP-Seq_ESCs_Human1.18382707
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17569383
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16316176
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16111415
43ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12184268
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11657252
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11609730
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11415064
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10847794
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10204642
49* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09489270
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06248006
51TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06082316
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05990943
53* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05626426
54WDR5_24793694_ChIP-Seq_LNCAP_Human1.04852918
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04197372
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04117049
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03695801
58* BCL6_27268052_Chip-Seq_Bcells_Human1.03545566
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.02854978
60MYC_19829295_ChIP-Seq_ESCs_Human1.02804616
61SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02695003
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02313767
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02181422
64* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01850332
65* BCOR_27268052_Chip-Seq_Bcells_Human0.99746955
66AHR_22903824_ChIP-Seq_MCF-7_Human0.99349082
67ARNT_22903824_ChIP-Seq_MCF-7_Human0.99198541
68SMC4_20622854_ChIP-Seq_HELA_Human0.98888198
69PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98885105
70* STAT3_23295773_ChIP-Seq_U87_Human0.98431291
71VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98177281
72* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97686890
73ESR1_21235772_ChIP-Seq_MCF-7_Human0.97489230
74TCF4_23295773_ChIP-Seq_U87_Human0.97048597
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96640860
76TP53_22573176_ChIP-Seq_HFKS_Human0.96088251
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96032577
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95824014
79P300_27268052_Chip-Seq_Bcells_Human0.95823444
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95126042
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94295303
82CBP_20019798_ChIP-Seq_JUKART_Human0.94295303
83* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92198058
84BCAT_22108803_ChIP-Seq_LS180_Human0.91907744
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91485056
86TAF2_19829295_ChIP-Seq_ESCs_Human0.90089505
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89945635
88RUNX2_22187159_ChIP-Seq_PCA_Human0.89901140
89PIAS1_25552417_ChIP-Seq_VCAP_Human0.89850371
90KDM2B_26808549_Chip-Seq_DND41_Human0.89169619
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87719807
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87649466
93EZH2_18974828_ChIP-Seq_MESCs_Mouse0.86888737
94RNF2_18974828_ChIP-Seq_MESCs_Mouse0.86888737
95BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.86349210
96CREB1_26743006_Chip-Seq_LNCaP_Human0.86133309
97P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.85912347
98RING1B_27294783_Chip-Seq_ESCs_Mouse0.85666149
99RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85360020
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85106823

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.76914676
2MP0002822_catalepsy3.03121296
3MP0003878_abnormal_ear_physiology2.56398769
4MP0005377_hearing/vestibular/ear_phenot2.56398769
5MP0001188_hyperpigmentation2.41749958
6MP0001986_abnormal_taste_sensitivity2.39709716
7MP0001502_abnormal_circadian_rhythm2.35847336
8MP0004043_abnormal_pH_regulation2.19269190
9MP0001968_abnormal_touch/_nociception2.15518291
10MP0005174_abnormal_tail_pigmentation2.13336249
11MP0005551_abnormal_eye_electrophysiolog2.13090072
12MP0001501_abnormal_sleep_pattern2.12909724
13MP0004381_abnormal_hair_follicle2.08491720
14MP0002653_abnormal_ependyma_morphology2.06682333
15MP0005646_abnormal_pituitary_gland1.93675879
16MP0002928_abnormal_bile_duct1.86752947
17MP0002876_abnormal_thyroid_physiology1.80094829
18MP0003195_calcinosis1.79343311
19MP0008995_early_reproductive_senescence1.77081247
20MP0002735_abnormal_chemical_nociception1.66658414
21MP0008961_abnormal_basal_metabolism1.62525408
22MP0008875_abnormal_xenobiotic_pharmacok1.60820085
23MP0002638_abnormal_pupillary_reflex1.60290202
24MP0005409_darkened_coat_color1.60290068
25MP0005423_abnormal_somatic_nervous1.57354330
26MP0005645_abnormal_hypothalamus_physiol1.53796705
27MP0003787_abnormal_imprinting1.52594234
28MP0004133_heterotaxia1.52244701
29MP0006292_abnormal_olfactory_placode1.51636316
30MP0009745_abnormal_behavioral_response1.45545972
31MP0005670_abnormal_white_adipose1.44439126
32MP0001970_abnormal_pain_threshold1.41800348
33MP0001485_abnormal_pinna_reflex1.41067659
34MP0001486_abnormal_startle_reflex1.40897967
35MP0002557_abnormal_social/conspecific_i1.37570349
36MP0005410_abnormal_fertilization1.37199817
37MP0002572_abnormal_emotion/affect_behav1.36955097
38MP0005448_abnormal_energy_balance1.34994197
39MP0006276_abnormal_autonomic_nervous1.33979071
40MP0002249_abnormal_larynx_morphology1.33299494
41MP0003879_abnormal_hair_cell1.32734115
42MP0003045_fibrosis1.27343878
43MP0000631_abnormal_neuroendocrine_gland1.27013064
44MP0004130_abnormal_muscle_cell1.23331175
45MP0002733_abnormal_thermal_nociception1.23196048
46MP0002063_abnormal_learning/memory/cond1.22174358
47MP0003635_abnormal_synaptic_transmissio1.22047257
48MP0003646_muscle_fatigue1.17512320
49MP0003880_abnormal_central_pattern1.15201838
50MP0002064_seizures1.15074278
51MP0002272_abnormal_nervous_system1.14435414
52MP0000015_abnormal_ear_pigmentation1.11742100
53MP0008872_abnormal_physiological_respon1.11104226
54MP0002138_abnormal_hepatobiliary_system1.10998666
55MP0000026_abnormal_inner_ear1.10388681
56MP0002933_joint_inflammation1.09377564
57MP0004142_abnormal_muscle_tone1.08421236
58MP0004885_abnormal_endolymph1.07398652
59MP0004145_abnormal_muscle_electrophysio1.07299540
60MP0009046_muscle_twitch1.07014210
61MP0001765_abnormal_ion_homeostasis1.05528057
62MP0004742_abnormal_vestibular_system1.04144524
63MP0003011_delayed_dark_adaptation1.03738104
64MP0005167_abnormal_blood-brain_barrier1.03203876
65MP0003172_abnormal_lysosome_physiology0.99603841
66MP0000470_abnormal_stomach_morphology0.99232620
67MP0008877_abnormal_DNA_methylation0.97587890
68MP0001873_stomach_inflammation0.97067069
69MP0000230_abnormal_systemic_arterial0.96818846
70MP0000778_abnormal_nervous_system0.95268286
71MP0005253_abnormal_eye_physiology0.94902686
72MP0003283_abnormal_digestive_organ0.94124255
73MP0001348_abnormal_lacrimal_gland0.93614390
74MP0002693_abnormal_pancreas_physiology0.92105217
75MP0002909_abnormal_adrenal_gland0.91575727
76MP0005310_abnormal_salivary_gland0.90760732
77MP0001944_abnormal_pancreas_morphology0.90242911
78MP0005083_abnormal_biliary_tract0.89107187
79MP0002102_abnormal_ear_morphology0.88299327
80MP0004924_abnormal_behavior0.87657853
81MP0005386_behavior/neurological_phenoty0.87657853
82MP0001963_abnormal_hearing_physiology0.87409236
83MP0002736_abnormal_nociception_after0.87235562
84MP0005535_abnormal_body_temperature0.83328578
85MP0002254_reproductive_system_inflammat0.81644249
86MP0002734_abnormal_mechanical_nocicepti0.81303642
87MP0001919_abnormal_reproductive_system0.81043313
88MP0000013_abnormal_adipose_tissue0.80138699
89MP0002067_abnormal_sensory_capabilities0.79941400
90MP0001756_abnormal_urination0.78063085
91MP0003698_abnormal_male_reproductive0.77279655
92MP0002229_neurodegeneration0.76384634
93MP0002752_abnormal_somatic_nervous0.75224891
94MP0002277_abnormal_respiratory_mucosa0.73674258
95MP0005595_abnormal_vascular_smooth0.71700121
96MP0005075_abnormal_melanosome_morpholog0.70633997
97MP0004859_abnormal_synaptic_plasticity0.69216852
98MP0002882_abnormal_neuron_morphology0.67667381
99MP0002837_dystrophic_cardiac_calcinosis0.67431841
100MP0005195_abnormal_posterior_eye0.67095486

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)5.09939433
2Congenital stationary night blindness (HP:0007642)4.70721002
3Chronic hepatic failure (HP:0100626)4.22300073
4Progressive cerebellar ataxia (HP:0002073)3.92546671
5Attenuation of retinal blood vessels (HP:0007843)3.72763774
6Nephronophthisis (HP:0000090)3.69000601
7Molar tooth sign on MRI (HP:0002419)3.52812836
8Abnormality of midbrain morphology (HP:0002418)3.52812836
9Decreased circulating renin level (HP:0003351)3.45781583
10Abnormal rod and cone electroretinograms (HP:0008323)3.43062364
11Abnormality of the renal medulla (HP:0100957)3.21705982
12Pancreatic cysts (HP:0001737)3.15238739
13Hyperventilation (HP:0002883)3.13406827
14Decreased central vision (HP:0007663)3.02365827
15Absent/shortened dynein arms (HP:0200106)3.01225014
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.01225014
17Polydipsia (HP:0001959)2.95826030
18Abnormal drinking behavior (HP:0030082)2.95826030
19Pancreatic fibrosis (HP:0100732)2.89911943
20True hermaphroditism (HP:0010459)2.85409576
21Cystic liver disease (HP:0006706)2.85263162
22Bony spicule pigmentary retinopathy (HP:0007737)2.72637937
23Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.72413134
24Obstructive sleep apnea (HP:0002870)2.66416966
25Type II lissencephaly (HP:0007260)2.63222942
26Abnormal respiratory motile cilium morphology (HP:0005938)2.62987969
27Abnormal respiratory epithelium morphology (HP:0012253)2.62987969
28Large for gestational age (HP:0001520)2.62844572
29Severe visual impairment (HP:0001141)2.56837749
30Rib fusion (HP:0000902)2.53564029
31Protruding tongue (HP:0010808)2.51246752
32Clumsiness (HP:0002312)2.50620042
33Hyperkalemia (HP:0002153)2.49843337
34Abnormality of the fingertips (HP:0001211)2.49676429
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49520568
36Neoplasm of the heart (HP:0100544)2.45855872
37Tubular atrophy (HP:0000092)2.42370153
38Hypoplastic ischia (HP:0003175)2.38499081
39Abnormality of the aortic arch (HP:0012303)2.36566788
40Stomach cancer (HP:0012126)2.26059063
41Congenital hepatic fibrosis (HP:0002612)2.25873831
42Abnormality of the renal cortex (HP:0011035)2.25190193
43Cerebellar dysplasia (HP:0007033)2.24047493
44Abnormality of renin-angiotensin system (HP:0000847)2.18010709
45Patellar aplasia (HP:0006443)2.17970484
46Gaze-evoked nystagmus (HP:0000640)2.17693732
47Medial flaring of the eyebrow (HP:0010747)2.17231739
48Abnormal ciliary motility (HP:0012262)2.15037859
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.14661451
50Broad-based gait (HP:0002136)2.14096497
51Absent speech (HP:0001344)2.11623016
52Polyuria (HP:0000103)2.09689618
53Pigmentary retinal degeneration (HP:0001146)2.08706074
54Sleep apnea (HP:0010535)2.07872954
55Bulbous nose (HP:0000414)2.05131594
56Mesangial abnormality (HP:0001966)2.01364555
57Tachypnea (HP:0002789)2.01351149
58Abnormal respiratory motile cilium physiology (HP:0012261)1.99632197
59Truncal obesity (HP:0001956)1.98853188
60Widely spaced teeth (HP:0000687)1.97816823
61Aplasia/Hypoplasia of the patella (HP:0006498)1.96455438
62Agitation (HP:0000713)1.94043635
63Hypoplastic nipples (HP:0002557)1.92751330
64Tubulointerstitial nephritis (HP:0001970)1.92506705
65Abnormality of the ischium (HP:0003174)1.92043390
66Testicular atrophy (HP:0000029)1.89776081
67Prolonged QT interval (HP:0001657)1.89459638
68Abnormality of the pubic bones (HP:0003172)1.86698560
69Tented upper lip vermilion (HP:0010804)1.82942353
70Macular degeneration (HP:0000608)1.82725399
71Diplopia (HP:0000651)1.80002062
72Abnormality of binocular vision (HP:0011514)1.80002062
73Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78691293
74Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76597444
75Male pseudohermaphroditism (HP:0000037)1.75645158
76Hemiparesis (HP:0001269)1.74714126
77Occipital encephalocele (HP:0002085)1.73982339
78Gait imbalance (HP:0002141)1.73060564
79Choroideremia (HP:0001139)1.72163525
80Macroglossia (HP:0000158)1.71935743
81Abnormal urine output (HP:0012590)1.71921175
82Abnormality of the renal collecting system (HP:0004742)1.71347857
83Abnormality of chloride homeostasis (HP:0011422)1.69568273
84Optic nerve coloboma (HP:0000588)1.67989338
85Chorioretinal atrophy (HP:0000533)1.67648409
86Pendular nystagmus (HP:0012043)1.67597083
87Stage 5 chronic kidney disease (HP:0003774)1.67591638
88Intellectual disability, severe (HP:0010864)1.67461522
89Poor coordination (HP:0002370)1.67265756
90Anencephaly (HP:0002323)1.66261603
91Hypoalbuminemia (HP:0003073)1.65740840
92Abnormal albumin level (HP:0012116)1.65740840
93Thyroid-stimulating hormone excess (HP:0002925)1.64576180
94Febrile seizures (HP:0002373)1.64252856
95Impaired smooth pursuit (HP:0007772)1.63946372
96Chronic bronchitis (HP:0004469)1.61928384
97Abolished electroretinogram (ERG) (HP:0000550)1.61739130
98Abnormality of the nasal septum (HP:0000419)1.61092362
99Duplicated collecting system (HP:0000081)1.60713318
100Concave nail (HP:0001598)1.60407799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.49127453
2FRK3.99506520
3SIK23.36198172
4WNK42.78138097
5TLK12.51067629
6INSRR2.45462989
7MAP2K62.34452425
8TNK22.16707494
9NTRK31.94574363
10SIK11.79262276
11BLK1.71062229
12AKT31.68111366
13TXK1.67910022
14DAPK21.63421197
15ADRBK21.60992991
16MARK21.60400006
17TAOK31.59224783
18GRK11.55155223
19WNK31.47583348
20CAMK1D1.44185598
21PRKD21.39577186
22MAP3K71.38764067
23CASK1.34538871
24BMPR1B1.34489004
25HIPK21.33686809
26MUSK1.27363870
27CDK121.20116190
28ACVR1B1.18519556
29CHUK1.18361533
30TNIK1.14319087
31WNK11.14286422
32CAMK1G1.11988851
33MAP4K11.10596086
34STK111.09191632
35SGK21.06081955
36EPHA31.05311767
37RPS6KA21.02268079
38BRD41.02218481
39NTRK21.00812399
40MAP4K20.97495496
41RPS6KA60.97255388
42MARK10.94335573
43NLK0.94290081
44NME10.89918539
45SGK4940.84938746
46SGK2230.84938746
47PINK10.84228966
48IKBKB0.84054746
49KIT0.83902239
50MAPK130.83590984
51SIK30.83459380
52ERBB20.82715302
53ADRBK10.82637280
54CAMKK10.81450782
55PRKCH0.80900824
56GRK60.78132722
57CDC42BPA0.77748139
58MAP2K20.74455842
59PAK30.73834543
60RPS6KL10.73812316
61RPS6KC10.73812316
62IKBKE0.73238525
63PTK2B0.71578963
64IRAK10.70891526
65CAMK10.70721528
66FGFR20.69619685
67STK380.69002140
68PRKAA10.68425556
69PRKAA20.68356977
70MARK30.67684951
71PRKD30.66500045
72BTK0.66004109
73CAMK40.65505354
74ITK0.63534991
75EPHB10.63011074
76DYRK1B0.62679458
77MAPK80.58930079
78TRIB30.57830374
79TRPM70.55957002
80MAPK70.54398670
81MAP3K40.50836632
82FES0.50074846
83SGK30.49871453
84PRKCZ0.49865269
85TEC0.49851963
86UHMK10.47340268
87ZAP700.47027319
88MAPK10.46138733
89SGK10.45670901
90SYK0.44474011
91RIPK40.44315382
92DYRK20.43530773
93MTOR0.42952465
94TAOK20.41229365
95MAPK30.40882952
96PRKD10.40876361
97DYRK1A0.40524920
98NEK20.40434446
99PRKCG0.40274021
100PDPK10.38270446

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005912.63343431
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.60323648
3Phototransduction_Homo sapiens_hsa047442.17901892
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.98499674
5Circadian rhythm_Homo sapiens_hsa047101.83378969
6Nicotine addiction_Homo sapiens_hsa050331.81033221
7Notch signaling pathway_Homo sapiens_hsa043301.72215327
8Insulin secretion_Homo sapiens_hsa049111.70800747
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.69329289
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67618791
11Ether lipid metabolism_Homo sapiens_hsa005651.65426142
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.64346347
13Taste transduction_Homo sapiens_hsa047421.54801709
14Morphine addiction_Homo sapiens_hsa050321.53077715
15Dorso-ventral axis formation_Homo sapiens_hsa043201.51096800
16ABC transporters_Homo sapiens_hsa020101.44446509
17Cocaine addiction_Homo sapiens_hsa050301.43922644
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43524269
19Ovarian steroidogenesis_Homo sapiens_hsa049131.40598243
20Regulation of autophagy_Homo sapiens_hsa041401.40094322
21Circadian entrainment_Homo sapiens_hsa047131.35017000
22Serotonergic synapse_Homo sapiens_hsa047261.34893395
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.33986564
24Glutamatergic synapse_Homo sapiens_hsa047241.31502085
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25426828
26Lysine degradation_Homo sapiens_hsa003101.23218409
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.22378447
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22310745
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22197954
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.19903541
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19081238
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16502043
33Cholinergic synapse_Homo sapiens_hsa047251.15912602
34Caffeine metabolism_Homo sapiens_hsa002321.14027589
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.12009122
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05588099
37MAPK signaling pathway_Homo sapiens_hsa040101.04616833
38cAMP signaling pathway_Homo sapiens_hsa040241.01736460
39Calcium signaling pathway_Homo sapiens_hsa040201.01309156
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99992976
41Pancreatic secretion_Homo sapiens_hsa049720.99909973
42GABAergic synapse_Homo sapiens_hsa047270.98424325
43Salivary secretion_Homo sapiens_hsa049700.96170752
44Arachidonic acid metabolism_Homo sapiens_hsa005900.94571016
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94296823
46Oxytocin signaling pathway_Homo sapiens_hsa049210.93618418
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91985609
48Primary immunodeficiency_Homo sapiens_hsa053400.91105352
49Renin secretion_Homo sapiens_hsa049240.90749463
50Type II diabetes mellitus_Homo sapiens_hsa049300.89339132
51Amphetamine addiction_Homo sapiens_hsa050310.88631819
52Nitrogen metabolism_Homo sapiens_hsa009100.86802029
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86135657
54Olfactory transduction_Homo sapiens_hsa047400.84314580
55Long-term depression_Homo sapiens_hsa047300.84038365
56GnRH signaling pathway_Homo sapiens_hsa049120.81161686
57T cell receptor signaling pathway_Homo sapiens_hsa046600.81004034
58Dopaminergic synapse_Homo sapiens_hsa047280.80917082
59Type I diabetes mellitus_Homo sapiens_hsa049400.77484002
60Choline metabolism in cancer_Homo sapiens_hsa052310.76419974
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74327675
62Glycerolipid metabolism_Homo sapiens_hsa005610.72231294
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69560945
64Axon guidance_Homo sapiens_hsa043600.68648904
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.67832723
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.67367701
67Autoimmune thyroid disease_Homo sapiens_hsa053200.67094329
68Insulin resistance_Homo sapiens_hsa049310.65972871
69Hedgehog signaling pathway_Homo sapiens_hsa043400.65196407
70Gastric acid secretion_Homo sapiens_hsa049710.63942146
71Estrogen signaling pathway_Homo sapiens_hsa049150.63348711
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61565479
73Tryptophan metabolism_Homo sapiens_hsa003800.61273665
74FoxO signaling pathway_Homo sapiens_hsa040680.60341742
75Butanoate metabolism_Homo sapiens_hsa006500.60212068
76Sphingolipid metabolism_Homo sapiens_hsa006000.59665750
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58373085
78VEGF signaling pathway_Homo sapiens_hsa043700.57583441
79mTOR signaling pathway_Homo sapiens_hsa041500.56952768
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56810015
81Allograft rejection_Homo sapiens_hsa053300.56725614
82Chemical carcinogenesis_Homo sapiens_hsa052040.56474282
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55808783
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55526013
85Ras signaling pathway_Homo sapiens_hsa040140.54972688
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.54676431
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54399839
88Graft-versus-host disease_Homo sapiens_hsa053320.53458762
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53005698
90Asthma_Homo sapiens_hsa053100.52112904
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51790535
92TNF signaling pathway_Homo sapiens_hsa046680.50847578
93B cell receptor signaling pathway_Homo sapiens_hsa046620.50737217
94Osteoclast differentiation_Homo sapiens_hsa043800.50709266
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50616212
96Inositol phosphate metabolism_Homo sapiens_hsa005620.50003108
97Basal cell carcinoma_Homo sapiens_hsa052170.49077190
98Melanogenesis_Homo sapiens_hsa049160.48367402
99Sulfur relay system_Homo sapiens_hsa041220.45373656
100Bile secretion_Homo sapiens_hsa049760.45373606

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