KIAA1257

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.77388447
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.89090652
3tryptophan catabolic process (GO:0006569)3.86435639
4indole-containing compound catabolic process (GO:0042436)3.86435639
5indolalkylamine catabolic process (GO:0046218)3.86435639
6DNA deamination (GO:0045006)3.83588050
7indolalkylamine metabolic process (GO:0006586)3.82358248
8epithelial cilium movement (GO:0003351)3.71123302
9L-fucose catabolic process (GO:0042355)3.63550486
10fucose catabolic process (GO:0019317)3.63550486
11L-fucose metabolic process (GO:0042354)3.63550486
12detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.57882704
13kynurenine metabolic process (GO:0070189)3.52805036
14cellular ketone body metabolic process (GO:0046950)3.42730073
15platelet dense granule organization (GO:0060155)3.40542878
16response to pheromone (GO:0019236)3.39748595
17protein polyglutamylation (GO:0018095)3.39434633
18detection of light stimulus involved in sensory perception (GO:0050962)3.33435201
19detection of light stimulus involved in visual perception (GO:0050908)3.33435201
20cilium or flagellum-dependent cell motility (GO:0001539)3.31352313
21tryptophan metabolic process (GO:0006568)3.25311787
22cilium movement (GO:0003341)3.24825309
23photoreceptor cell maintenance (GO:0045494)3.23219011
24piRNA metabolic process (GO:0034587)3.20453244
25nonmotile primary cilium assembly (GO:0035058)3.19770575
26axoneme assembly (GO:0035082)3.18695996
27retinal cone cell development (GO:0046549)3.12063364
28kidney morphogenesis (GO:0060993)3.11933398
29water-soluble vitamin biosynthetic process (GO:0042364)3.11648578
30ketone body metabolic process (GO:1902224)3.06076420
31respiratory chain complex IV assembly (GO:0008535)3.05290593
32neural tube formation (GO:0001841)3.03150588
33regulation of translation, ncRNA-mediated (GO:0045974)2.99115118
34negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.99115118
35negative regulation of translation, ncRNA-mediated (GO:0040033)2.99115118
36regulation of meiosis I (GO:0060631)2.98614980
37multicellular organism reproduction (GO:0032504)2.94545949
38regulation of cilium movement (GO:0003352)2.94242218
39centriole replication (GO:0007099)2.92325901
40protein complex biogenesis (GO:0070271)2.88077214
41regulation of glucokinase activity (GO:0033131)2.86515504
42regulation of hexokinase activity (GO:1903299)2.86515504
43indole-containing compound metabolic process (GO:0042430)2.85260775
44G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85102378
45negative regulation of telomere maintenance (GO:0032205)2.82579740
46regulation of posttranscriptional gene silencing (GO:0060147)2.81774568
47regulation of gene silencing by miRNA (GO:0060964)2.81774568
48regulation of gene silencing by RNA (GO:0060966)2.81774568
49cilium morphogenesis (GO:0060271)2.81675422
50cilium organization (GO:0044782)2.81361153
51behavioral response to ethanol (GO:0048149)2.76559136
52preassembly of GPI anchor in ER membrane (GO:0016254)2.75777416
53reciprocal DNA recombination (GO:0035825)2.75352927
54reciprocal meiotic recombination (GO:0007131)2.75352927
55replication fork processing (GO:0031297)2.75243522
56DNA methylation involved in gamete generation (GO:0043046)2.74628706
57mitochondrial respiratory chain complex I assembly (GO:0032981)2.73573662
58NADH dehydrogenase complex assembly (GO:0010257)2.73573662
59mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.73573662
60protein K11-linked deubiquitination (GO:0035871)2.72769558
61cilium assembly (GO:0042384)2.72061451
62cellular biogenic amine catabolic process (GO:0042402)2.71444994
63amine catabolic process (GO:0009310)2.71444994
64regulation of hippo signaling (GO:0035330)2.69571590
65sulfation (GO:0051923)2.69320513
66signal peptide processing (GO:0006465)2.68307052
67sperm motility (GO:0030317)2.67744562
68male meiosis I (GO:0007141)2.66975051
69reflex (GO:0060004)2.65987987
70cytochrome complex assembly (GO:0017004)2.65979519
71protein localization to cilium (GO:0061512)2.61774394
72protein-cofactor linkage (GO:0018065)2.61012756
73recombinational repair (GO:0000725)2.60835816
74double-strand break repair via homologous recombination (GO:0000724)2.59937625
75photoreceptor cell development (GO:0042461)2.59826287
76neuronal action potential (GO:0019228)2.58506723
77adaptation of signaling pathway (GO:0023058)2.58462623
78somite rostral/caudal axis specification (GO:0032525)2.58374206
79primary amino compound metabolic process (GO:1901160)2.58078739
80mitochondrial respiratory chain complex assembly (GO:0033108)2.57805532
81mannosylation (GO:0097502)2.55730435
82negative regulation of DNA-dependent DNA replication (GO:2000104)2.55586649
83DNA double-strand break processing (GO:0000729)2.54693815
84regulation of rhodopsin mediated signaling pathway (GO:0022400)2.53986762
85regulation of mesoderm development (GO:2000380)2.53797822
86negative regulation of mast cell activation (GO:0033004)2.52167014
87serotonin metabolic process (GO:0042428)2.51157623
88somite development (GO:0061053)2.49432847
89regulation of nuclear cell cycle DNA replication (GO:0033262)2.49330375
90cornea development in camera-type eye (GO:0061303)2.49318769
91rhodopsin mediated signaling pathway (GO:0016056)2.47053959
92spinal cord motor neuron differentiation (GO:0021522)2.46241661
93NAD biosynthetic process (GO:0009435)2.45285561
94synapsis (GO:0007129)2.44230288
95male meiosis (GO:0007140)2.43686616
96protein prenylation (GO:0018342)2.42452260
97prenylation (GO:0097354)2.42452260
98gamma-aminobutyric acid transport (GO:0015812)2.42014425
99establishment of protein localization to Golgi (GO:0072600)2.40370170
100nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.39897743

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.68001497
2EZH2_22144423_ChIP-Seq_EOC_Human3.18285757
3VDR_22108803_ChIP-Seq_LS180_Human3.09438954
4GBX2_23144817_ChIP-Seq_PC3_Human3.05019690
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.74343588
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43076544
7IGF1R_20145208_ChIP-Seq_DFB_Human2.39501716
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.36983383
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36772817
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32007191
11TAF15_26573619_Chip-Seq_HEK293_Human2.26475154
12P300_19829295_ChIP-Seq_ESCs_Human2.18228061
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17218408
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.15716989
15EWS_26573619_Chip-Seq_HEK293_Human2.11625090
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11419513
17FUS_26573619_Chip-Seq_HEK293_Human2.03172631
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.92201951
19ER_23166858_ChIP-Seq_MCF-7_Human1.91895998
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85349249
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80030520
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76897766
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76765400
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73210743
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72192447
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72088763
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70431888
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68702850
29CBP_20019798_ChIP-Seq_JUKART_Human1.67604916
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67604916
31IRF1_19129219_ChIP-ChIP_H3396_Human1.64266639
32SMAD4_21799915_ChIP-Seq_A2780_Human1.59599699
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59185030
34BCAT_22108803_ChIP-Seq_LS180_Human1.58772182
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.55323877
36STAT3_23295773_ChIP-Seq_U87_Human1.54494408
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52223889
38TP53_22573176_ChIP-Seq_HFKS_Human1.51660696
39AR_25329375_ChIP-Seq_VCAP_Human1.51367840
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49131861
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48965129
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48965129
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.47868112
44TCF4_23295773_ChIP-Seq_U87_Human1.44327036
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42261771
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41913049
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41461275
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41269492
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40858985
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.40715529
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38856241
52SOX2_19829295_ChIP-Seq_ESCs_Human1.38759111
53NANOG_19829295_ChIP-Seq_ESCs_Human1.38759111
54* TCF4_22108803_ChIP-Seq_LS180_Human1.36634674
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34672296
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.33099024
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.32631800
58RUNX2_22187159_ChIP-Seq_PCA_Human1.32509696
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31049518
60REST_21632747_ChIP-Seq_MESCs_Mouse1.30857635
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29902949
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.29902949
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29507781
64MYC_18940864_ChIP-ChIP_HL60_Human1.28409365
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.26401597
66KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25273089
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25124554
68RNF2_27304074_Chip-Seq_NSC_Mouse1.24977069
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24958595
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.23167225
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.23081245
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22579092
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.21433209
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.18812192
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17978542
76AR_21572438_ChIP-Seq_LNCaP_Human1.17449974
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.16533395
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15191500
79AR_20517297_ChIP-Seq_VCAP_Human1.14284249
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14187050
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13216777
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.12176984
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11324718
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08456114
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08369837
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.08140571
87NCOR_22424771_ChIP-Seq_293T_Human1.07915991
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04900480
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04224467
90CDX2_22108803_ChIP-Seq_LS180_Human1.04216091
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04213476
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02847540
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.02341678
94* HOXB7_26014856_ChIP-Seq_BT474_Human1.02000186
95P53_22387025_ChIP-Seq_ESCs_Mouse1.00432281
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99341507
97ELK1_19687146_ChIP-ChIP_HELA_Human0.98821328
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98370580
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.95330125
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.92972019

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.36721682
2MP0003195_calcinosis3.16960252
3MP0006292_abnormal_olfactory_placode3.10570612
4MP0003787_abnormal_imprinting2.66096134
5MP0003136_yellow_coat_color2.46490694
6MP0005551_abnormal_eye_electrophysiolog2.38001722
7MP0002102_abnormal_ear_morphology2.28997670
8MP0002837_dystrophic_cardiac_calcinosis2.07441089
9MP0001968_abnormal_touch/_nociception1.98420025
10MP0006072_abnormal_retinal_apoptosis1.93618552
11MP0009046_muscle_twitch1.93589396
12MP0005646_abnormal_pituitary_gland1.86340550
13MP0009745_abnormal_behavioral_response1.84391736
14MP0000569_abnormal_digit_pigmentation1.84244106
15MP0003880_abnormal_central_pattern1.82879872
16MP0001501_abnormal_sleep_pattern1.81044488
17MP0004142_abnormal_muscle_tone1.80983147
18MP0002638_abnormal_pupillary_reflex1.77383977
19MP0002736_abnormal_nociception_after1.77308992
20MP0001485_abnormal_pinna_reflex1.77189911
21MP0005253_abnormal_eye_physiology1.76116410
22MP0001986_abnormal_taste_sensitivity1.75277251
23MP0006276_abnormal_autonomic_nervous1.70657283
24MP0001984_abnormal_olfaction1.70171051
25MP0003718_maternal_effect1.67195755
26MP0004147_increased_porphyrin_level1.63811274
27MP0003646_muscle_fatigue1.63232914
28MP0004885_abnormal_endolymph1.59626129
29MP0000631_abnormal_neuroendocrine_gland1.59020087
30MP0005645_abnormal_hypothalamus_physiol1.58872933
31MP0003121_genomic_imprinting1.56832702
32MP0008872_abnormal_physiological_respon1.56353295
33MP0002938_white_spotting1.56117199
34MP0002272_abnormal_nervous_system1.55034576
35MP0002876_abnormal_thyroid_physiology1.52115799
36MP0000427_abnormal_hair_cycle1.51093202
37MP0004133_heterotaxia1.51055787
38MP0002653_abnormal_ependyma_morphology1.50063829
39MP0001529_abnormal_vocalization1.47647819
40MP0001486_abnormal_startle_reflex1.42182085
41MP0005084_abnormal_gallbladder_morpholo1.36556609
42MP0002735_abnormal_chemical_nociception1.36291638
43MP0004043_abnormal_pH_regulation1.35273970
44MP0005410_abnormal_fertilization1.34354252
45MP0008789_abnormal_olfactory_epithelium1.33193507
46MP0003890_abnormal_embryonic-extraembry1.31311460
47MP0003011_delayed_dark_adaptation1.31067043
48MP0010386_abnormal_urinary_bladder1.30403887
49MP0000372_irregular_coat_pigmentation1.29976130
50MP0008995_early_reproductive_senescence1.27113796
51MP0002572_abnormal_emotion/affect_behav1.22600271
52MP0002557_abnormal_social/conspecific_i1.21267880
53MP0005174_abnormal_tail_pigmentation1.21218973
54MP0008058_abnormal_DNA_repair1.18823279
55MP0002160_abnormal_reproductive_system1.18626604
56MP0004742_abnormal_vestibular_system1.16269384
57MP0005389_reproductive_system_phenotype1.15630154
58MP0003122_maternal_imprinting1.13538559
59MP0008875_abnormal_xenobiotic_pharmacok1.13436985
60MP0002064_seizures1.12650006
61MP0001970_abnormal_pain_threshold1.12403965
62MP0002277_abnormal_respiratory_mucosa1.12237920
63MP0005377_hearing/vestibular/ear_phenot1.12213196
64MP0003878_abnormal_ear_physiology1.12213196
65MP0002928_abnormal_bile_duct1.11761296
66MP0003283_abnormal_digestive_organ1.11539022
67MP0002138_abnormal_hepatobiliary_system1.11297797
68MP0003698_abnormal_male_reproductive1.09910623
69MP0001929_abnormal_gametogenesis1.09591844
70MP0001905_abnormal_dopamine_level1.09434771
71MP0002234_abnormal_pharynx_morphology1.05418977
72MP0004924_abnormal_behavior1.04970075
73MP0005386_behavior/neurological_phenoty1.04970075
74MP0002733_abnormal_thermal_nociception1.02235823
75MP0005499_abnormal_olfactory_system0.99624304
76MP0005394_taste/olfaction_phenotype0.99624304
77MP0002751_abnormal_autonomic_nervous0.99536888
78MP0005423_abnormal_somatic_nervous0.99052250
79MP0002067_abnormal_sensory_capabilities0.97811631
80MP0005195_abnormal_posterior_eye0.97187497
81MP0005075_abnormal_melanosome_morpholog0.95219319
82MP0002210_abnormal_sex_determination0.94831961
83MP0003119_abnormal_digestive_system0.92739562
84MP0002163_abnormal_gland_morphology0.91872739
85MP0005167_abnormal_blood-brain_barrier0.91284199
86MP0001919_abnormal_reproductive_system0.91232515
87MP0003635_abnormal_synaptic_transmissio0.90151038
88MP0001293_anophthalmia0.89746886
89MP0002752_abnormal_somatic_nervous0.88363712
90MP0000653_abnormal_sex_gland0.87250013
91MP0002909_abnormal_adrenal_gland0.86518140
92MP0002254_reproductive_system_inflammat0.86082765
93MP0002095_abnormal_skin_pigmentation0.86009684
94MP0008057_abnormal_DNA_replication0.85911657
95MP0000026_abnormal_inner_ear0.85872326
96MP0002734_abnormal_mechanical_nocicepti0.84030485
97MP0005085_abnormal_gallbladder_physiolo0.83969606
98MP0002822_catalepsy0.83785727
99MP0001324_abnormal_eye_pigmentation0.82539870
100MP0002693_abnormal_pancreas_physiology0.82491151

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.53964020
2Pancreatic fibrosis (HP:0100732)4.16936831
3True hermaphroditism (HP:0010459)4.03713019
4Abnormality of midbrain morphology (HP:0002418)3.77533902
5Molar tooth sign on MRI (HP:0002419)3.77533902
6Congenital stationary night blindness (HP:0007642)3.42524963
7Nephronophthisis (HP:0000090)3.41848498
8Medial flaring of the eyebrow (HP:0010747)3.31303403
9Attenuation of retinal blood vessels (HP:0007843)3.13618193
10Abnormality of the renal medulla (HP:0100957)3.01722232
11Abnormality of the renal cortex (HP:0011035)3.00498432
12Abolished electroretinogram (ERG) (HP:0000550)2.88571529
13Cystic liver disease (HP:0006706)2.82456722
14Type II lissencephaly (HP:0007260)2.78827651
15Chronic hepatic failure (HP:0100626)2.75066101
16Dynein arm defect of respiratory motile cilia (HP:0012255)2.72814269
17Absent/shortened dynein arms (HP:0200106)2.72814269
18Gait imbalance (HP:0002141)2.62618941
19Abnormal rod and cone electroretinograms (HP:0008323)2.61587434
20Congenital primary aphakia (HP:0007707)2.59608755
21Gaze-evoked nystagmus (HP:0000640)2.58905167
22Progressive cerebellar ataxia (HP:0002073)2.58443619
23Pendular nystagmus (HP:0012043)2.54400911
24Sclerocornea (HP:0000647)2.48803614
25Abnormal ciliary motility (HP:0012262)2.46469186
26Hyperventilation (HP:0002883)2.46131234
27Abnormal drinking behavior (HP:0030082)2.45929034
28Polydipsia (HP:0001959)2.45929034
29Tubular atrophy (HP:0000092)2.44838392
30Hypothermia (HP:0002045)2.42292564
31Bony spicule pigmentary retinopathy (HP:0007737)2.38299062
32Nephrogenic diabetes insipidus (HP:0009806)2.38257851
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.35591759
34Decreased central vision (HP:0007663)2.34596417
35Congenital, generalized hypertrichosis (HP:0004540)2.33925090
36Abnormal respiratory epithelium morphology (HP:0012253)2.31954320
37Abnormal respiratory motile cilium morphology (HP:0005938)2.31954320
38Genetic anticipation (HP:0003743)2.29472016
39Progressive inability to walk (HP:0002505)2.26577730
40Large for gestational age (HP:0001520)2.25338572
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.24781936
42Abnormality of alanine metabolism (HP:0010916)2.21501299
43Hyperalaninemia (HP:0003348)2.21501299
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21501299
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20539463
46Genital tract atresia (HP:0001827)2.19991706
47Anencephaly (HP:0002323)2.19164538
48Male pseudohermaphroditism (HP:0000037)2.18088306
49Abnormality of the labia minora (HP:0012880)2.17672661
50Inability to walk (HP:0002540)2.17612947
51Aplasia/Hypoplasia of the fovea (HP:0008060)2.15072718
52Hypoplasia of the fovea (HP:0007750)2.15072718
53Congenital hepatic fibrosis (HP:0002612)2.15067257
54Congenital sensorineural hearing impairment (HP:0008527)2.14479872
55Methylmalonic acidemia (HP:0002912)2.13703910
56Renal cortical cysts (HP:0000803)2.13095580
57Optic nerve hypoplasia (HP:0000609)2.11176002
58Vaginal atresia (HP:0000148)2.10506382
59Abnormal respiratory motile cilium physiology (HP:0012261)2.07844112
60Cerebellar dysplasia (HP:0007033)2.06199516
61Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05637256
62Bile duct proliferation (HP:0001408)2.05514661
63Abnormal biliary tract physiology (HP:0012439)2.05514661
64Intestinal atresia (HP:0011100)2.03370053
65Abnormality of the pons (HP:0007361)2.02378940
66Furrowed tongue (HP:0000221)2.02226529
67Aplasia/Hypoplasia of the uvula (HP:0010293)1.99504718
68Polyuria (HP:0000103)1.98498697
69Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97053734
70Lissencephaly (HP:0001339)1.95701962
71Hypoplasia of the pons (HP:0012110)1.95612420
72Increased corneal curvature (HP:0100692)1.95566910
73Keratoconus (HP:0000563)1.95566910
74Febrile seizures (HP:0002373)1.94504907
75Increased CSF lactate (HP:0002490)1.94104122
76Poor coordination (HP:0002370)1.93606578
77Broad-based gait (HP:0002136)1.89741258
78Methylmalonic aciduria (HP:0012120)1.89573626
79Mitochondrial inheritance (HP:0001427)1.88598068
80Postaxial foot polydactyly (HP:0001830)1.88173714
81Abnormality of macular pigmentation (HP:0008002)1.88092871
82Abnormality of the fovea (HP:0000493)1.85362621
83Constricted visual fields (HP:0001133)1.84683794
84Supernumerary spleens (HP:0009799)1.83508175
85Acute necrotizing encephalopathy (HP:0006965)1.82563720
86Retinitis pigmentosa (HP:0000510)1.81401463
87Hemiparesis (HP:0001269)1.80499376
88Stomach cancer (HP:0012126)1.78280905
893-Methylglutaconic aciduria (HP:0003535)1.77299519
90Decreased circulating renin level (HP:0003351)1.76327459
91Postaxial hand polydactyly (HP:0001162)1.75745308
92Abnormality of the ileum (HP:0001549)1.74526093
93Optic disc pallor (HP:0000543)1.73376587
94Septo-optic dysplasia (HP:0100842)1.73077506
95Preaxial hand polydactyly (HP:0001177)1.72096001
96Ketoacidosis (HP:0001993)1.71619807
97Bilateral microphthalmos (HP:0007633)1.70171952
98Ketosis (HP:0001946)1.69206843
99Retinal dysplasia (HP:0007973)1.68188238
100Protruding tongue (HP:0010808)1.67969984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.82346346
2BMPR1B3.19070421
3ZAK2.97775000
4WNK32.77048143
5ADRBK22.75630431
6ACVR1B2.63210917
7INSRR2.51833977
8GRK12.49140516
9TAOK32.13774160
10PINK12.11695630
11NUAK12.09784078
12MAP4K22.08836695
13TNIK1.90258452
14TRIM281.81091293
15TLK11.75323033
16MAPK131.72771622
17CASK1.63528366
18MAP3K41.55490232
19OXSR11.47858299
20WNK41.44748460
21MKNK21.39784323
22TXK1.36625603
23MST41.26042226
24TIE11.18014832
25BRSK21.16477081
26STK391.11737328
27DAPK21.07601933
28VRK11.05062575
29DYRK21.04795587
30NTRK31.04024147
31STK38L1.01743316
32PNCK1.00665236
33TGFBR10.97526333
34ADRBK10.96719482
35PLK20.96509222
36PRKCE0.90764776
37PLK30.90591116
38PRKCG0.90131701
39PLK40.87343278
40PAK30.86882310
41MAP2K70.85612949
42TEC0.78254533
43FGFR20.78144798
44PTK2B0.75977514
45CSNK1G10.75433769
46EIF2AK30.75124350
47MARK10.73495097
48IRAK10.71990283
49NEK20.70876934
50BCKDK0.69741068
51CSNK1G20.69506669
52MKNK10.67254435
53VRK20.67029677
54STK30.65508643
55WEE10.63718059
56MAPK150.63591540
57NLK0.62713688
58PASK0.62015047
59CSNK1G30.59149977
60MARK30.58747259
61PHKG20.58136615
62PHKG10.58136615
63CHUK0.56266870
64TAF10.56255196
65NTRK20.56010607
66IKBKB0.53407068
67CDC70.52421424
68TNK20.52295551
69ERBB30.51534069
70DYRK30.51428304
71PLK10.51259522
72EPHA40.50510787
73CSNK1A1L0.48493520
74PKN10.48332540
75MUSK0.47207816
76STK160.46689155
77CDK190.46521495
78KIT0.45752696
79STK110.45594036
80CDK30.44659432
81PRKCQ0.44512688
82PRKCI0.43386218
83ITK0.43201516
84CAMK2A0.43128597
85FER0.41275687
86BCR0.41187173
87PRKACA0.41162283
88SIK20.40578887
89CSNK1A10.39208483
90OBSCN0.38874867
91MAPKAPK30.38513081
92PRKG10.38197920
93FLT30.37773973
94NME10.37020951
95PIK3CA0.35959470
96PRKAA20.35777202
97RPS6KA50.34674147
98CSNK1D0.34240643
99ATR0.32819483
100AKT30.32121176

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.80933791
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60244743
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.55753246
4Butanoate metabolism_Homo sapiens_hsa006502.43644055
5Homologous recombination_Homo sapiens_hsa034402.43061806
6Oxidative phosphorylation_Homo sapiens_hsa001902.27459438
7Linoleic acid metabolism_Homo sapiens_hsa005912.18971301
8Nitrogen metabolism_Homo sapiens_hsa009102.18684518
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.13393528
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12574724
11Nicotine addiction_Homo sapiens_hsa050332.04793072
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.94874230
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93808409
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.92177792
15Protein export_Homo sapiens_hsa030601.91465320
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89200929
17Selenocompound metabolism_Homo sapiens_hsa004501.87792715
18Fanconi anemia pathway_Homo sapiens_hsa034601.86326559
19Tryptophan metabolism_Homo sapiens_hsa003801.82454305
20RNA polymerase_Homo sapiens_hsa030201.82444274
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.79844518
22Basal transcription factors_Homo sapiens_hsa030221.74168968
23Taste transduction_Homo sapiens_hsa047421.69441022
24Parkinsons disease_Homo sapiens_hsa050121.65183662
25Olfactory transduction_Homo sapiens_hsa047401.62342494
26Ether lipid metabolism_Homo sapiens_hsa005651.55887145
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53942427
28Propanoate metabolism_Homo sapiens_hsa006401.53055835
29ABC transporters_Homo sapiens_hsa020101.39405971
30Caffeine metabolism_Homo sapiens_hsa002321.37364080
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.37042540
32RNA degradation_Homo sapiens_hsa030181.32889861
33Morphine addiction_Homo sapiens_hsa050321.32793808
34Huntingtons disease_Homo sapiens_hsa050161.26905999
35Peroxisome_Homo sapiens_hsa041461.18326329
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17197589
37Insulin secretion_Homo sapiens_hsa049111.16281520
38Regulation of autophagy_Homo sapiens_hsa041401.13715123
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09267357
40Serotonergic synapse_Homo sapiens_hsa047261.07265071
41Chemical carcinogenesis_Homo sapiens_hsa052041.05455532
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04934047
43Collecting duct acid secretion_Homo sapiens_hsa049661.04802688
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03957417
45Retinol metabolism_Homo sapiens_hsa008301.02682669
46GABAergic synapse_Homo sapiens_hsa047271.01424897
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97297545
48Alzheimers disease_Homo sapiens_hsa050100.97070070
49Cardiac muscle contraction_Homo sapiens_hsa042600.95229323
50Glutamatergic synapse_Homo sapiens_hsa047240.94404621
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.93143031
52Circadian entrainment_Homo sapiens_hsa047130.92236236
53Non-homologous end-joining_Homo sapiens_hsa034500.91586117
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90912158
55beta-Alanine metabolism_Homo sapiens_hsa004100.88397551
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85914641
57Ovarian steroidogenesis_Homo sapiens_hsa049130.85695232
58One carbon pool by folate_Homo sapiens_hsa006700.83130916
59Arachidonic acid metabolism_Homo sapiens_hsa005900.82214902
60Purine metabolism_Homo sapiens_hsa002300.79402354
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77641390
62Proteasome_Homo sapiens_hsa030500.75512451
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.71843663
64Histidine metabolism_Homo sapiens_hsa003400.71716025
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70501975
66Fat digestion and absorption_Homo sapiens_hsa049750.70262618
67Glycerolipid metabolism_Homo sapiens_hsa005610.68160421
68Circadian rhythm_Homo sapiens_hsa047100.66776937
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65400525
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63202614
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.61745278
72Metabolic pathways_Homo sapiens_hsa011000.61047082
73Mismatch repair_Homo sapiens_hsa034300.60526388
74Steroid biosynthesis_Homo sapiens_hsa001000.58204983
75Salivary secretion_Homo sapiens_hsa049700.57056981
76Calcium signaling pathway_Homo sapiens_hsa040200.56893526
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55813720
78Fatty acid degradation_Homo sapiens_hsa000710.55616459
79Type I diabetes mellitus_Homo sapiens_hsa049400.55073427
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53523114
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51503265
82Dopaminergic synapse_Homo sapiens_hsa047280.51143081
83Dorso-ventral axis formation_Homo sapiens_hsa043200.51005214
84Hedgehog signaling pathway_Homo sapiens_hsa043400.50413491
85Vitamin digestion and absorption_Homo sapiens_hsa049770.48667690
86Nucleotide excision repair_Homo sapiens_hsa034200.43879598
87Fatty acid metabolism_Homo sapiens_hsa012120.42595964
88Pyrimidine metabolism_Homo sapiens_hsa002400.42272729
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41429580
90Cocaine addiction_Homo sapiens_hsa050300.40054794
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38913632
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37012670
93Mineral absorption_Homo sapiens_hsa049780.36992754
94Asthma_Homo sapiens_hsa053100.36894853
95Long-term depression_Homo sapiens_hsa047300.36761255
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.34119532
97Cholinergic synapse_Homo sapiens_hsa047250.33953260
98Primary immunodeficiency_Homo sapiens_hsa053400.32472880
99cAMP signaling pathway_Homo sapiens_hsa040240.32452219
100RNA transport_Homo sapiens_hsa030130.32049325

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