KIAA1147

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-tyrosine autophosphorylation (GO:0038083)4.73242874
2histone H3-K36 demethylation (GO:0070544)4.66937956
3positive regulation of gamma-delta T cell activation (GO:0046645)4.46484519
4negative regulation of erythrocyte differentiation (GO:0045647)3.93784071
5positive regulation of Rap GTPase activity (GO:0032854)3.87621695
6regulation of gamma-delta T cell differentiation (GO:0045586)3.86884196
7cellular response to ethanol (GO:0071361)3.84871359
8regulation of gamma-delta T cell activation (GO:0046643)3.76104075
9L-amino acid import (GO:0043092)3.74486228
10regulation of ARF protein signal transduction (GO:0032012)3.64307495
11phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.63171521
12histone H3-K9 demethylation (GO:0033169)3.49406089
13positive thymic T cell selection (GO:0045059)3.43351684
14negative thymic T cell selection (GO:0045060)3.40735305
15histone lysine demethylation (GO:0070076)3.40379717
16regulation of Rap GTPase activity (GO:0032317)3.39055996
17B cell receptor signaling pathway (GO:0050853)3.36400714
18negative T cell selection (GO:0043383)3.26608453
19positive T cell selection (GO:0043368)3.25187168
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.20822211
21negative regulation of cell killing (GO:0031342)3.20822211
22thymic T cell selection (GO:0045061)3.16111755
23histone demethylation (GO:0016577)3.14761825
24response to muramyl dipeptide (GO:0032495)3.13939257
25embryonic retina morphogenesis in camera-type eye (GO:0060059)3.02539176
26regulation of histone H3-K27 methylation (GO:0061085)3.00109781
27negative regulation of histone methylation (GO:0031061)2.97272175
28cytoplasmic mRNA processing body assembly (GO:0033962)2.96216404
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.94923357
30T cell selection (GO:0045058)2.94054350
31regulation of B cell receptor signaling pathway (GO:0050855)2.92853564
32histone H3-K4 trimethylation (GO:0080182)2.92252655
33endothelium development (GO:0003158)2.91325785
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.82069145
35positive regulation of respiratory burst (GO:0060267)2.80915125
36heart valve formation (GO:0003188)2.74568719
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.72145751
38amino acid import (GO:0043090)2.70165137
39antigen processing and presentation of endogenous antigen (GO:0019883)2.66728631
40negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.66063721
41regulation of nucleobase-containing compound transport (GO:0032239)2.65332584
42Rap protein signal transduction (GO:0032486)2.65289738
43positive regulation of B cell differentiation (GO:0045579)2.64238820
44regulation of NFAT protein import into nucleus (GO:0051532)2.57964727
45Notch signaling involved in heart development (GO:0061314)2.56191309
46protein dealkylation (GO:0008214)2.55756388
47protein demethylation (GO:0006482)2.55756388
48positive regulation of humoral immune response (GO:0002922)2.52636251
49regulation of RNA export from nucleus (GO:0046831)2.51588483
50interkinetic nuclear migration (GO:0022027)2.48486395
51peptidyl-threonine phosphorylation (GO:0018107)2.47681730
52histone H3-K9 modification (GO:0061647)2.47492350
53regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.46337054
54peptidyl-threonine modification (GO:0018210)2.43940863
55positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.39635832
56T cell migration (GO:0072678)2.39015217
57establishment of nucleus localization (GO:0040023)2.37762665
58regulation of beta-amyloid formation (GO:1902003)2.33119690
59response to interleukin-15 (GO:0070672)2.32756745
60negative regulation of myotube differentiation (GO:0010832)2.32728403
61regulation of B cell differentiation (GO:0045577)2.31642949
62histone H3-K4 methylation (GO:0051568)2.30598591
63mannose metabolic process (GO:0006013)2.30490490
64positive regulation of Rac GTPase activity (GO:0032855)2.28861979
65lipid translocation (GO:0034204)2.27529878
66phospholipid translocation (GO:0045332)2.27529878
67positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.27102844
68male sex determination (GO:0030238)2.26794448
69positive regulation of granulocyte differentiation (GO:0030854)2.26298959
70positive regulation of DNA-templated transcription, initiation (GO:2000144)2.23621262
71nerve growth factor signaling pathway (GO:0038180)2.22921116
72definitive hemopoiesis (GO:0060216)2.22914137
73positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.22826629
74positive regulation of cellular amide metabolic process (GO:0034250)2.22581918
75histone H4-K16 acetylation (GO:0043984)2.21520551
76embryonic camera-type eye morphogenesis (GO:0048596)2.20450823
77regulation of ARF GTPase activity (GO:0032312)2.19757969
78negative regulation of dendrite morphogenesis (GO:0050774)2.19527160
79pre-miRNA processing (GO:0031054)2.19513315
80activation of JUN kinase activity (GO:0007257)2.18832746
81nuclear pore complex assembly (GO:0051292)2.18484752
82detection of other organism (GO:0098543)2.18188579
83positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.14873445
84epithelial cell differentiation involved in prostate gland development (GO:0060742)2.14781129
85peptidyl-lysine trimethylation (GO:0018023)2.12094844
86germinal center formation (GO:0002467)2.12088538
87B cell homeostasis (GO:0001782)2.11612480
88negative regulation of lymphocyte mediated immunity (GO:0002707)2.11260321
89detection of bacterium (GO:0016045)2.10913003
90positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.10431745
91megakaryocyte development (GO:0035855)2.10120969
92negative regulation of neurotransmitter secretion (GO:0046929)2.10061243
93macrophage activation involved in immune response (GO:0002281)2.08596800
94oocyte development (GO:0048599)2.08185841
95peptidyl-lysine dimethylation (GO:0018027)2.07948725
96exocrine pancreas development (GO:0031017)2.07919122
97insulin-like growth factor receptor signaling pathway (GO:0048009)2.07585975
98negative regulation of histone modification (GO:0031057)2.06961546
99negative regulation of toll-like receptor signaling pathway (GO:0034122)2.04239122
100nucleus localization (GO:0051647)2.04186686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.92999596
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.50643821
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.36392857
4VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.04777656
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.56678558
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.45682736
7RUNX_20019798_ChIP-Seq_JUKART_Human2.44445572
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.43090495
9MYC_22102868_ChIP-Seq_BL_Human2.36873273
10TCF7_22412390_ChIP-Seq_EML_Mouse2.30177608
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.28685426
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21983825
13SCL_19346495_ChIP-Seq_HPC-7_Human2.20901659
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11400600
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90362065
16DROSHA_22980978_ChIP-Seq_HELA_Human1.89168767
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.89099178
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.88991066
19IRF8_27001747_Chip-Seq_BMDM_Mouse1.77635474
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75016613
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.74119634
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73092606
23KDM2B_26808549_Chip-Seq_DND41_Human1.72702132
24CTNNB1_20460455_ChIP-Seq_HCT116_Human1.72675249
25TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.71006380
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67820753
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.66502629
28DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.65234246
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62159236
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61698562
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60187884
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58985427
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57308057
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.56026923
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.55538604
36* FOXA2_19822575_ChIP-Seq_HepG2_Human1.55009382
37KDM2B_26808549_Chip-Seq_JURKAT_Human1.53034356
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.45049634
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44869198
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.43443398
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42410625
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.41961792
43MYB_26560356_Chip-Seq_TH2_Human1.41777365
44VDR_24763502_ChIP-Seq_THP-1_Human1.38674927
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36623354
46MYB_26560356_Chip-Seq_TH1_Human1.34211376
47VDR_21846776_ChIP-Seq_THP-1_Human1.32042934
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.29687431
49* MAF_26560356_Chip-Seq_TH1_Human1.29025039
50GATA1_22025678_ChIP-Seq_K562_Human1.28834427
51* KDM2B_26808549_Chip-Seq_K562_Human1.28794762
52AHR_22903824_ChIP-Seq_MCF-7_Human1.28675346
53VDR_24787735_ChIP-Seq_THP-1_Human1.26603524
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24742393
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22564273
56LXR_22158963_ChIP-Seq_LIVER_Mouse1.21896597
57ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21621960
58SPI1_23127762_ChIP-Seq_K562_Human1.21193700
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20471704
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19264610
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.18741403
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17812219
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17761986
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17718927
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13512808
66GATA3_27048872_Chip-Seq_THYMUS_Human1.11043237
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10944440
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10246111
69GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09708577
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09501322
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.09174004
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08271891
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06347955
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05546514
75GATA1_19941827_ChIP-Seq_MEL86_Mouse1.04589993
76RUNX1_22412390_ChIP-Seq_EML_Mouse1.04233670
77UTX_26944678_Chip-Seq_JUKART_Human1.04173523
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03938748
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.03844246
80EZH2_22144423_ChIP-Seq_EOC_Human1.03054055
81PU_27001747_Chip-Seq_BMDM_Mouse1.02476887
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00747755
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00720129
84TBX20_22080862_ChIP-Seq_HEART_Mouse0.99064731
85TBX20_22328084_ChIP-Seq_HEART_Mouse0.99064731
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98823384
87SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98177116
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96702554
89RUNX1_27514584_Chip-Seq_MCF-7_Human0.96281211
90PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95540861
91NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93917523
92YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93255903
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91790952
94ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91774465
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90815181
96NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90322346
97GATA1_19941826_ChIP-Seq_K562_Human0.88946672
98* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87501278
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85360539
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85305604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.90826998
2MP0003303_peritoneal_inflammation3.45794959
3MP0002009_preneoplasia3.36090139
4MP0003300_gastrointestinal_ulcer2.99339355
5MP0003763_abnormal_thymus_physiology2.79724346
6MP0003690_abnormal_glial_cell2.74130774
7MP0002138_abnormal_hepatobiliary_system2.70230784
8MP0010234_abnormal_vibrissa_follicle2.44757420
9MP0002139_abnormal_hepatobiliary_system2.42199619
10MP0002396_abnormal_hematopoietic_system2.40497195
11MP0005409_darkened_coat_color2.21675840
12MP0003183_abnormal_peptide_metabolism2.10766993
13MP0005365_abnormal_bile_salt2.01037602
14MP0005076_abnormal_cell_differentiation1.94388510
15MP0000465_gastrointestinal_hemorrhage1.91820111
16MP0001851_eye_inflammation1.90339172
17MP0003868_abnormal_feces_composition1.88617978
18MP0001800_abnormal_humoral_immune1.82087437
19MP0004808_abnormal_hematopoietic_stem1.77382902
20MP0010352_gastrointestinal_tract_polyps1.74659768
21MP0003091_abnormal_cell_migration1.73178704
22MP0002166_altered_tumor_susceptibility1.63446393
23MP0003724_increased_susceptibility_to1.61188983
24MP0003172_abnormal_lysosome_physiology1.58127754
25MP0010678_abnormal_skin_adnexa1.55712526
26MP0010155_abnormal_intestine_physiology1.54161886
27MP0003436_decreased_susceptibility_to1.51714850
28MP0000685_abnormal_immune_system1.50620665
29MP0003866_abnormal_defecation1.47555951
30MP0010368_abnormal_lymphatic_system1.47202659
31MP0003191_abnormal_cellular_cholesterol1.44936765
32MP0002398_abnormal_bone_marrow1.43925342
33MP0009278_abnormal_bone_marrow1.41982968
34MP0001835_abnormal_antigen_presentation1.41830402
35MP0005387_immune_system_phenotype1.38994193
36MP0001790_abnormal_immune_system1.38994193
37MP0000703_abnormal_thymus_morphology1.38660682
38MP0003252_abnormal_bile_duct1.35462511
39MP0002420_abnormal_adaptive_immunity1.33739019
40MP0005000_abnormal_immune_tolerance1.31527450
41MP0001819_abnormal_immune_cell1.30927144
42MP0002723_abnormal_immune_serum1.27973466
43MP0005310_abnormal_salivary_gland1.25551280
44MP0003828_pulmonary_edema1.25432159
45MP0002452_abnormal_antigen_presenting1.25260758
46MP0004947_skin_inflammation1.22795968
47MP0000383_abnormal_hair_follicle1.22413396
48MP0002405_respiratory_system_inflammati1.21257422
49MP0000716_abnormal_immune_system1.21054875
50MP0004264_abnormal_extraembryonic_tissu1.19022902
51MP0001666_abnormal_nutrient_absorption1.16854218
52MP0002419_abnormal_innate_immunity1.15258513
53MP0005666_abnormal_adipose_tissue1.12906274
54MP0005025_abnormal_response_to1.11390145
55MP0001346_abnormal_lacrimal_gland1.11132209
56MP0001873_stomach_inflammation1.10718614
57MP0005248_abnormal_Harderian_gland1.07488201
58MP0005464_abnormal_platelet_physiology1.05845765
59MP0001915_intracranial_hemorrhage1.05357805
60MP0000920_abnormal_myelination1.03853127
61MP0003453_abnormal_keratinocyte_physiol1.03597532
62MP0002006_tumorigenesis1.01933591
63MP0003329_amyloid_beta_deposits1.01446320
64MP0000689_abnormal_spleen_morphology1.00657128
65MP0002722_abnormal_immune_system1.00607688
66MP0002998_abnormal_bone_remodeling0.98667666
67MP0001879_abnormal_lymphatic_vessel0.98514955
68MP0004185_abnormal_adipocyte_glucose0.93472676
69MP0005220_abnormal_exocrine_pancreas0.93391888
70MP0002429_abnormal_blood_cell0.91415746
71MP0009672_abnormal_birth_weight0.91354910
72MP0003632_abnormal_nervous_system0.90551346
73MP0003705_abnormal_hypodermis_morpholog0.89837797
74MP0009840_abnormal_foam_cell0.88734833
75MP0000604_amyloidosis0.87197136
76MP0004859_abnormal_synaptic_plasticity0.85882502
77MP0003943_abnormal_hepatobiliary_system0.83752538
78MP0001730_embryonic_growth_arrest0.83709188
79MP0005671_abnormal_response_to0.82464049
80MP0005397_hematopoietic_system_phenotyp0.81210427
81MP0001545_abnormal_hematopoietic_system0.81210427
82MP0009115_abnormal_fat_cell0.80765575
83MP0005621_abnormal_cell_physiology0.80248578
84MP0004381_abnormal_hair_follicle0.80174780
85MP0008569_lethality_at_weaning0.79179273
86MP0003787_abnormal_imprinting0.78403556
87MP0008961_abnormal_basal_metabolism0.78158669
88MP0003045_fibrosis0.75134478
89MP0002877_abnormal_melanocyte_morpholog0.74963184
90MP0001853_heart_inflammation0.74333773
91MP0000537_abnormal_urethra_morphology0.71065967
92MP0008260_abnormal_autophagy0.70906351
93MP0004043_abnormal_pH_regulation0.70608805
94MP0000609_abnormal_liver_physiology0.70282603
95MP0001845_abnormal_inflammatory_respons0.69312932
96MP0005085_abnormal_gallbladder_physiolo0.68708858
97MP0004130_abnormal_muscle_cell0.67807198
98MP0000249_abnormal_blood_vessel0.66604876
99MP0005167_abnormal_blood-brain_barrier0.65717315
100MP0005058_abnormal_lysosome_morphology0.65094184

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.58161997
2Hypoglycemic seizures (HP:0002173)3.10898516
3Enlarged penis (HP:0000040)3.08790633
4Colitis (HP:0002583)3.06848418
5Eczematoid dermatitis (HP:0000976)3.02621492
6Papilledema (HP:0001085)2.96815240
7Obstructive sleep apnea (HP:0002870)2.87684697
8Spontaneous hematomas (HP:0007420)2.79518910
9Papillary thyroid carcinoma (HP:0002895)2.71804587
10Viral hepatitis (HP:0006562)2.60851078
11Subacute progressive viral hepatitis (HP:0006572)2.58542985
12Elfin facies (HP:0004428)2.57842555
13Macroorchidism (HP:0000053)2.53632264
14Agammaglobulinemia (HP:0004432)2.50263643
15Neonatal hypoglycemia (HP:0001998)2.41565083
16Abnormality of monocarboxylic acid metabolism (HP:0010996)2.37891457
17Gastrointestinal inflammation (HP:0004386)2.34023481
18Neurofibrillary tangles (HP:0002185)2.31719548
19Growth hormone excess (HP:0000845)2.31315846
20Hyperinsulinemic hypoglycemia (HP:0000825)2.31090808
21Germ cell neoplasia (HP:0100728)2.29140882
22Inflammation of the large intestine (HP:0002037)2.26607040
23Cellulitis (HP:0100658)2.24486495
24Dysmetric saccades (HP:0000641)2.20512918
25Recurrent viral infections (HP:0004429)2.19235793
26Truncal obesity (HP:0001956)2.15918393
27Scanning speech (HP:0002168)2.13907357
28Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.13268220
29Thick nail (HP:0001805)2.12259908
30Pancreatic islet-cell hyperplasia (HP:0004510)2.11729917
31Long foot (HP:0001833)2.11726419
32Gastrointestinal stroma tumor (HP:0100723)2.10774442
33Deep venous thrombosis (HP:0002625)2.10265412
34T lymphocytopenia (HP:0005403)2.08923479
35Recurrent bacterial skin infections (HP:0005406)2.05193045
36Slow saccadic eye movements (HP:0000514)2.05025560
37Flat acetabular roof (HP:0003180)2.03722147
38Recurrent gram-negative bacterial infections (HP:0005420)1.98580300
39Cerebral inclusion bodies (HP:0100314)1.98199853
40Recurrent abscess formation (HP:0002722)1.94200695
41Recurrent sinusitis (HP:0011108)1.94087197
42Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.93993105
43Hemorrhage of the eye (HP:0011885)1.93960548
44Coarse hair (HP:0002208)1.92233556
45Complement deficiency (HP:0004431)1.89168404
46Acute lymphatic leukemia (HP:0006721)1.89166894
47Panhypogammaglobulinemia (HP:0003139)1.89048678
48Meningitis (HP:0001287)1.88719600
49Broad face (HP:0000283)1.87436217
50Thickened helices (HP:0000391)1.87299101
51Visceral angiomatosis (HP:0100761)1.86440934
52Transitional cell carcinoma of the bladder (HP:0006740)1.85655046
53Advanced eruption of teeth (HP:0006288)1.84982424
54Heterotopia (HP:0002282)1.84920676
55Acute myeloid leukemia (HP:0004808)1.84734541
56Conjunctival telangiectasia (HP:0000524)1.82884782
57Symptomatic seizures (HP:0011145)1.82504591
58Osteomyelitis (HP:0002754)1.81120409
59Lower limb asymmetry (HP:0100559)1.78735981
60Recurrent bronchitis (HP:0002837)1.76945501
61Hemangiomatosis (HP:0007461)1.76603845
62Abnormality of the vasculature of the conjunctiva (HP:0008054)1.75973760
63Abnormality of T cell number (HP:0011839)1.75508852
64Hematochezia (HP:0002573)1.75435999
65Gingivitis (HP:0000230)1.73723336
66Increased circulating renin level (HP:0000848)1.73548414
67Interstitial pulmonary disease (HP:0006530)1.71454005
68Leiomyosarcoma (HP:0100243)1.71396894
69Uterine leiomyosarcoma (HP:0002891)1.71396894
70Polygenic inheritance (HP:0010982)1.69886048
71Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69492922
72Abnormality of endocrine pancreas physiology (HP:0012093)1.69479778
73Abnormality of the pancreatic islet cells (HP:0006476)1.69479778
74Gastrointestinal carcinoma (HP:0002672)1.68965875
75Malignant gastrointestinal tract tumors (HP:0006749)1.68965875
76IgM deficiency (HP:0002850)1.67999868
77Hypoglycemic coma (HP:0001325)1.67632922
78Insulin-resistant diabetes mellitus (HP:0000831)1.66843921
79Bronchomalacia (HP:0002780)1.65209379
80Bladder carcinoma (HP:0002862)1.65126838
81Bladder neoplasm (HP:0009725)1.65126838
82Recurrent fungal infections (HP:0002841)1.64637641
83Abnormal delayed hypersensitivity skin test (HP:0002963)1.63672818
84Pulmonary embolism (HP:0002204)1.61166554
85Neuronal loss in central nervous system (HP:0002529)1.59455009
86Glomerulonephritis (HP:0000099)1.57375200
87Supranuclear gaze palsy (HP:0000605)1.56710544
88Neoplasm of the tracheobronchial system (HP:0100552)1.55716329
89Lymphopenia (HP:0001888)1.54164285
90Apathy (HP:0000741)1.53481458
91Deep palmar crease (HP:0006191)1.53451038
92Autoimmune hemolytic anemia (HP:0001890)1.52722319
93Chronic diarrhea (HP:0002028)1.52527051
94Vasculitis (HP:0002633)1.52076520
95Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.51864489
96Urethral obstruction (HP:0000796)1.51713645
97Subaortic stenosis (HP:0001682)1.51497249
98Abnormality of the left ventricular outflow tract (HP:0011103)1.51497249
99Abnormality of complement system (HP:0005339)1.51330988
100Vertebral arch anomaly (HP:0008438)1.49531527

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.28270625
2PRPF4B3.64640562
3CDK123.22255607
4MAP3K132.75771440
5MAP3K102.52171762
6TRIB32.23326232
7EEF2K2.13501833
8MAP4K12.13167909
9MAP3K142.13166361
10FES2.00516872
11FGFR31.98092278
12BRD41.95492900
13FGFR41.84897973
14RIPK41.81499945
15RIPK11.42074458
16CAMKK11.41133525
17JAK11.40464966
18SGK21.40257741
19SMG11.35384392
20SGK31.33856941
21TYK21.29854610
22MARK21.23685699
23BTK1.20419544
24CDK61.19893719
25NEK61.19606956
26MAP3K91.18166679
27BLK1.13518922
28NLK1.11267252
29ITK1.11138178
30TNK21.10229050
31CAMK1D1.09952277
32FGFR21.09091600
33CSK1.07891558
34PASK1.04220620
35IRAK21.03463041
36PRKD31.02393167
37MAP3K71.01964541
38SIK21.01172334
39CAMK1G0.99284421
40ICK0.96069260
41RET0.94096595
42NTRK20.92065950
43IKBKE0.91519349
44TYRO30.90537486
45SGK4940.89447049
46SGK2230.89447049
47CAMKK20.88883335
48KSR20.88082374
49HCK0.87623112
50CSF1R0.87396357
51PKN20.86290486
52YES10.85736836
53NEK90.85641707
54ZAP700.85569761
55IRAK10.84374071
56HIPK20.83747627
57MELK0.82740699
58SYK0.80853138
59PDK10.79312472
60IRAK40.77038755
61STK240.76921156
62PDGFRB0.76595881
63JAK20.73558334
64UHMK10.73290590
65MTOR0.71455396
66PDGFRA0.70598355
67WNK10.70235093
68PRKCH0.67798381
69TEC0.67507860
70MAP3K20.64610346
71EPHA30.63309610
72LCK0.63093517
73CDC42BPA0.62646101
74STK110.62328629
75MAPK100.61992260
76LYN0.61595872
77NTRK30.61279526
78CDK40.61249562
79MAP3K10.59735878
80SIK10.59139074
81CDK90.57767275
82TAOK30.57481813
83JAK30.57152108
84MAPK110.55559577
85PDPK10.53698350
86MAPK70.52810078
87SGK10.51468121
88MAPK120.51134441
89TBK10.50219078
90AKT30.49254766
91PTK60.47605317
92BMPR20.46045904
93FYN0.45040949
94RPS6KB20.43769221
95RPS6KB10.43579932
96PRKCQ0.42311351
97ALK0.41194736
98KIT0.41110089
99TNIK0.40753563
100EPHB10.40667077

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.21509562
2Non-small cell lung cancer_Homo sapiens_hsa052231.80846243
3Chronic myeloid leukemia_Homo sapiens_hsa052201.66546987
4Acute myeloid leukemia_Homo sapiens_hsa052211.61180129
5Phosphatidylinositol signaling system_Homo sapiens_hsa040701.56419391
6Endometrial cancer_Homo sapiens_hsa052131.50793170
7Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48616649
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47373760
9T cell receptor signaling pathway_Homo sapiens_hsa046601.46892890
10Pancreatic cancer_Homo sapiens_hsa052121.44579243
11Long-term potentiation_Homo sapiens_hsa047201.33360676
12mTOR signaling pathway_Homo sapiens_hsa041501.33122888
13Dorso-ventral axis formation_Homo sapiens_hsa043201.31924648
14Phospholipase D signaling pathway_Homo sapiens_hsa040721.30132471
15Notch signaling pathway_Homo sapiens_hsa043301.27042433
16Renal cell carcinoma_Homo sapiens_hsa052111.26676324
17Osteoclast differentiation_Homo sapiens_hsa043801.24196785
18Inositol phosphate metabolism_Homo sapiens_hsa005621.22854486
19Choline metabolism in cancer_Homo sapiens_hsa052311.22713796
20Type II diabetes mellitus_Homo sapiens_hsa049301.22522159
21Neurotrophin signaling pathway_Homo sapiens_hsa047221.21529618
22Leishmaniasis_Homo sapiens_hsa051401.20645933
23Prolactin signaling pathway_Homo sapiens_hsa049171.16511318
24ErbB signaling pathway_Homo sapiens_hsa040121.13452792
25Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13085867
26Colorectal cancer_Homo sapiens_hsa052101.12576541
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.11832273
28Prostate cancer_Homo sapiens_hsa052151.11481079
29Longevity regulating pathway - mammal_Homo sapiens_hsa042111.10876732
30Glioma_Homo sapiens_hsa052141.10630479
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10484133
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09763183
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.08055594
34VEGF signaling pathway_Homo sapiens_hsa043701.07986610
35Adherens junction_Homo sapiens_hsa045201.07757346
36Staphylococcus aureus infection_Homo sapiens_hsa051501.07560165
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05796463
38Lysine degradation_Homo sapiens_hsa003101.05587610
39Bile secretion_Homo sapiens_hsa049761.03112986
40FoxO signaling pathway_Homo sapiens_hsa040681.02749484
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00548915
42Circadian rhythm_Homo sapiens_hsa047100.99253834
43Prion diseases_Homo sapiens_hsa050200.99002950
44GnRH signaling pathway_Homo sapiens_hsa049120.96214391
45Estrogen signaling pathway_Homo sapiens_hsa049150.95390483
46Hepatitis B_Homo sapiens_hsa051610.94970039
47Platelet activation_Homo sapiens_hsa046110.94424472
48Insulin resistance_Homo sapiens_hsa049310.93359841
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92428982
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91998254
51Other glycan degradation_Homo sapiens_hsa005110.91681847
52Thyroid cancer_Homo sapiens_hsa052160.91448243
53Measles_Homo sapiens_hsa051620.91426366
54Hepatitis C_Homo sapiens_hsa051600.90258646
55Influenza A_Homo sapiens_hsa051640.88530459
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.86763854
57Toxoplasmosis_Homo sapiens_hsa051450.85220320
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84044362
59Chemokine signaling pathway_Homo sapiens_hsa040620.83780293
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81785079
61Histidine metabolism_Homo sapiens_hsa003400.81451936
62Caffeine metabolism_Homo sapiens_hsa002320.79649846
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78054763
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.77571368
65HIF-1 signaling pathway_Homo sapiens_hsa040660.77566756
66Autoimmune thyroid disease_Homo sapiens_hsa053200.75456141
67Insulin signaling pathway_Homo sapiens_hsa049100.75370543
68Primary immunodeficiency_Homo sapiens_hsa053400.74811231
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.74499617
70MicroRNAs in cancer_Homo sapiens_hsa052060.74121434
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73233135
72Allograft rejection_Homo sapiens_hsa053300.71078694
73Complement and coagulation cascades_Homo sapiens_hsa046100.69889039
74TNF signaling pathway_Homo sapiens_hsa046680.68566487
75Rap1 signaling pathway_Homo sapiens_hsa040150.67678248
76Ras signaling pathway_Homo sapiens_hsa040140.64062288
77Herpes simplex infection_Homo sapiens_hsa051680.63849704
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62324773
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61691703
80Cholinergic synapse_Homo sapiens_hsa047250.61067619
81Tuberculosis_Homo sapiens_hsa051520.60954552
82ABC transporters_Homo sapiens_hsa020100.60878777
83Renin secretion_Homo sapiens_hsa049240.60196903
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57888954
85Graft-versus-host disease_Homo sapiens_hsa053320.57842284
86MAPK signaling pathway_Homo sapiens_hsa040100.57812543
87Thyroid hormone synthesis_Homo sapiens_hsa049180.57504967
88Type I diabetes mellitus_Homo sapiens_hsa049400.56411132
89Ovarian steroidogenesis_Homo sapiens_hsa049130.56112142
90Small cell lung cancer_Homo sapiens_hsa052220.55471021
91Pancreatic secretion_Homo sapiens_hsa049720.54663119
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53730124
93Long-term depression_Homo sapiens_hsa047300.53456664
94HTLV-I infection_Homo sapiens_hsa051660.52280182
95Apoptosis_Homo sapiens_hsa042100.50725873
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49615855
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49145350
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49108925
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48804135
100Amphetamine addiction_Homo sapiens_hsa050310.47620494

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