KIAA1109

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located on the long arm of chromosome 4 in a region that is associated with susceptibility to celiac disease. The encoded protein is similar to a Chinese hamster protein that is associated with spermatocyte and adipocyte differentiation. The C-terminus of the protein is also similar to a Caenorhabditis elegans protein that plays a role in lipid storage. In mammals, this protein is thought to function in the regulation of epithelial growth and differentiation, and in tumor development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.39985792
2establishment of nucleus localization (GO:0040023)3.41537818
3nucleus localization (GO:0051647)3.39999309
4interkinetic nuclear migration (GO:0022027)3.39997315
5cellular response to ethanol (GO:0071361)3.33176966
6histone H3-K36 demethylation (GO:0070544)3.28962463
7phospholipid translocation (GO:0045332)3.22824116
8lipid translocation (GO:0034204)3.22824116
9cerebellar Purkinje cell differentiation (GO:0021702)3.20808793
10establishment of protein localization to Golgi (GO:0072600)3.14296563
11monoubiquitinated protein deubiquitination (GO:0035520)3.10476419
12nerve growth factor signaling pathway (GO:0038180)3.08613479
13cytoplasmic mRNA processing body assembly (GO:0033962)2.99915083
14retrograde transport, vesicle recycling within Golgi (GO:0000301)2.96608099
15protein targeting to Golgi (GO:0000042)2.96265947
16macroautophagy (GO:0016236)2.95753142
17regulation of ARF protein signal transduction (GO:0032012)2.92305863
18histone H3-K9 demethylation (GO:0033169)2.90107637
19histone H3-K4 trimethylation (GO:0080182)2.85867897
20cellular response to epinephrine stimulus (GO:0071872)2.82536677
21Golgi to endosome transport (GO:0006895)2.77678888
22detection of molecule of bacterial origin (GO:0032490)2.77269494
23regulation of protein polyubiquitination (GO:1902914)2.76028864
24positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.74148295
25positive regulation of gamma-delta T cell activation (GO:0046645)2.71856609
26response to epinephrine (GO:0071871)2.67305329
27regulation of pigment cell differentiation (GO:0050932)2.64915848
28regulation of skeletal muscle cell differentiation (GO:2001014)2.64372782
29positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.56206200
30peptidyl-threonine phosphorylation (GO:0018107)2.54475355
31import into cell (GO:0098657)2.50148337
32negative regulation of neurotransmitter secretion (GO:0046929)2.48041317
33negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.47342037
34regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.44505629
35regulation of B cell receptor signaling pathway (GO:0050855)2.44379628
36histone lysine demethylation (GO:0070076)2.44163334
37regulation of Rap GTPase activity (GO:0032317)2.39601298
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.39553499
39regulation of beta-amyloid formation (GO:1902003)2.38240519
40peptidyl-threonine modification (GO:0018210)2.37273903
41negative regulation of cytosolic calcium ion concentration (GO:0051481)2.36740187
42negative regulation of cell killing (GO:0031342)2.35999480
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.35999480
44relaxation of cardiac muscle (GO:0055119)2.33864954
45protein K48-linked deubiquitination (GO:0071108)2.32769768
46regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.32269440
47negative regulation of neurotransmitter transport (GO:0051589)2.31877416
48myofibril assembly (GO:0030239)2.30848962
49histone demethylation (GO:0016577)2.29425806
50positive T cell selection (GO:0043368)2.26916802
51protein K11-linked deubiquitination (GO:0035871)2.26551505
52centrosome localization (GO:0051642)2.25806985
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.25536815
54regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.25407427
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.25203106
56hypotonic response (GO:0006971)2.23477095
57interleukin-6-mediated signaling pathway (GO:0070102)2.22514728
58cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.22047109
59microglial cell activation (GO:0001774)2.21733011
60insulin-like growth factor receptor signaling pathway (GO:0048009)2.20870178
61locomotory exploration behavior (GO:0035641)2.20382874
62B cell receptor signaling pathway (GO:0050853)2.18813841
63positive regulation of Rap GTPase activity (GO:0032854)2.17983068
64growth hormone receptor signaling pathway (GO:0060396)2.17668746
65regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.17160686
66embryonic retina morphogenesis in camera-type eye (GO:0060059)2.16101031
67pericardium development (GO:0060039)2.15978496
68regulation of relaxation of muscle (GO:1901077)2.15800573
69cellular response to monoamine stimulus (GO:0071868)2.14773955
70cellular response to catecholamine stimulus (GO:0071870)2.14773955
71regulation of gamma-delta T cell differentiation (GO:0045586)2.14678816
72positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.14292976
73negative regulation of inclusion body assembly (GO:0090084)2.14270946
74positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.14113228
75L-amino acid import (GO:0043092)2.13443844
76peptidyl-lysine trimethylation (GO:0018023)2.13355219
77protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.13147311
78cardiac muscle hypertrophy (GO:0003300)2.12818521
79protein targeting to vacuole (GO:0006623)2.11426473
80protein targeting to lysosome (GO:0006622)2.11426473
81establishment of protein localization to vacuole (GO:0072666)2.11426473
82positive regulation of developmental pigmentation (GO:0048087)2.09384631
83regulation of NFAT protein import into nucleus (GO:0051532)2.09254429
84peptidyl-serine phosphorylation (GO:0018105)2.08970301
85cardiac myofibril assembly (GO:0055003)2.08024775
86positive regulation of cardiac muscle hypertrophy (GO:0010613)2.07920635
87positive regulation of muscle hypertrophy (GO:0014742)2.07920635
88negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.07859273
89negative regulation of translation, ncRNA-mediated (GO:0040033)2.07859273
90regulation of translation, ncRNA-mediated (GO:0045974)2.07859273
91cellular extravasation (GO:0045123)2.07526473
92central nervous system projection neuron axonogenesis (GO:0021952)2.06817154
93cytoskeletal anchoring at plasma membrane (GO:0007016)2.06079247
94presynaptic membrane assembly (GO:0097105)2.05737655
95regulation of gamma-delta T cell activation (GO:0046643)2.05532875
96labyrinthine layer development (GO:0060711)2.05124557
97vesicle transport along microtubule (GO:0047496)2.04706488
98activated T cell proliferation (GO:0050798)2.04049377
99synaptic vesicle docking involved in exocytosis (GO:0016081)2.04032867
100cellular response to growth hormone stimulus (GO:0071378)2.03206152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD_19615063_ChIP-ChIP_OVARY_Human2.85799853
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.79834755
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.75655143
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.71484207
5GBX2_23144817_ChIP-Seq_PC3_Human2.61234814
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.39286009
7SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.19987912
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.08156290
9ZNF217_24962896_ChIP-Seq_MCF-7_Human2.01979220
10POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97426736
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96867366
12AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.94890465
13PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78093020
14PIAS1_25552417_ChIP-Seq_VCAP_Human1.73430046
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72892125
16TP53_16413492_ChIP-PET_HCT116_Human1.71299883
17SALL1_21062744_ChIP-ChIP_HESCs_Human1.70537696
18TAF15_26573619_Chip-Seq_HEK293_Human1.69801914
19SMAD4_21799915_ChIP-Seq_A2780_Human1.68363153
20AR_21572438_ChIP-Seq_LNCaP_Human1.67215881
21GATA1_22025678_ChIP-Seq_K562_Human1.63545055
22EZH2_22144423_ChIP-Seq_EOC_Human1.62011483
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61049993
24OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60084203
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.59346262
26CTNNB1_20460455_ChIP-Seq_HCT116_Human1.54430500
27* STAT3_23295773_ChIP-Seq_U87_Human1.52571459
28AHR_22903824_ChIP-Seq_MCF-7_Human1.52276670
29RUNX_20019798_ChIP-Seq_JUKART_Human1.47616759
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47301299
31TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.46439167
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46349133
33ARNT_22903824_ChIP-Seq_MCF-7_Human1.45754091
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41500073
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.41483673
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40981601
37TCF4_23295773_ChIP-Seq_U87_Human1.38790631
38DROSHA_22980978_ChIP-Seq_HELA_Human1.38022885
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36847009
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35086342
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35086342
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34482098
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.33133021
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32389325
45P300_19829295_ChIP-Seq_ESCs_Human1.31269243
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.26019326
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.25813588
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24524979
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24070746
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23682584
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23682584
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22845620
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.22449392
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20599461
55IGF1R_20145208_ChIP-Seq_DFB_Human1.20364874
56* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20100414
57YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20064452
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19903003
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19880661
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19865556
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19533849
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.18502488
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17871254
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17706693
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17511097
66WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15634389
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15075707
68KDM2B_26808549_Chip-Seq_REH_Human1.14756259
69FUS_26573619_Chip-Seq_HEK293_Human1.12688788
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.12483012
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12156133
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12010384
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10910600
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.10612844
75SMAD3_21741376_ChIP-Seq_HESCs_Human1.10227659
76IRF8_22096565_ChIP-ChIP_GC-B_Human1.10201079
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09517261
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08801909
79AR_25329375_ChIP-Seq_VCAP_Human1.07683167
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.07461376
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07388096
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.06977507
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06876937
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06861722
85CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06814854
86VDR_24787735_ChIP-Seq_THP-1_Human1.06183253
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.06135852
88BCAT_22108803_ChIP-Seq_LS180_Human1.06028717
89FOXO3_23340844_ChIP-Seq_DLD1_Human1.06026612
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05621937
91ER_23166858_ChIP-Seq_MCF-7_Human1.05106665
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.04479069
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03423491
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03375923
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02614632
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.01954932
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.01106128
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00775119
99P53_22387025_ChIP-Seq_ESCs_Mouse1.00708473
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00151644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.82845828
2MP0008057_abnormal_DNA_replication3.67259206
3MP0002009_preneoplasia3.32710556
4MP0003690_abnormal_glial_cell2.55840721
5MP0003045_fibrosis2.23986926
6MP0004130_abnormal_muscle_cell2.20394854
7MP0003787_abnormal_imprinting2.20289852
8MP0003300_gastrointestinal_ulcer2.17502343
9MP0004145_abnormal_muscle_electrophysio2.02933111
10MP0004270_analgesia1.95247518
11MP0002166_altered_tumor_susceptibility1.94981353
12MP0004084_abnormal_cardiac_muscle1.90496640
13MP0005409_darkened_coat_color1.87847961
14MP0001958_emphysema1.81836092
15MP0003724_increased_susceptibility_to1.75295842
16MP0004484_altered_response_of1.74412909
17MP0003091_abnormal_cell_migration1.71059736
18MP0004036_abnormal_muscle_relaxation1.69522986
19MP0003172_abnormal_lysosome_physiology1.66295412
20MP0004859_abnormal_synaptic_plasticity1.64001958
21MP0003183_abnormal_peptide_metabolism1.63162150
22MP0010352_gastrointestinal_tract_polyps1.51995917
23MP0003632_abnormal_nervous_system1.48823682
24MP0005248_abnormal_Harderian_gland1.48439380
25MP0001486_abnormal_startle_reflex1.45226688
26MP0003828_pulmonary_edema1.39297402
27MP0009780_abnormal_chondrocyte_physiolo1.38630566
28MP0003763_abnormal_thymus_physiology1.38346046
29MP0003635_abnormal_synaptic_transmissio1.36582036
30MP0008260_abnormal_autophagy1.35394422
31MP0000383_abnormal_hair_follicle1.31621253
32MP0001851_eye_inflammation1.31307798
33MP0005174_abnormal_tail_pigmentation1.29902520
34MP0002332_abnormal_exercise_endurance1.29592033
35MP0003633_abnormal_nervous_system1.23613548
36MP0002168_other_aberrant_phenotype1.23257593
37MP0001177_atelectasis1.21363703
38MP0003868_abnormal_feces_composition1.19972355
39MP0003631_nervous_system_phenotype1.19439949
40MP0000920_abnormal_myelination1.19259158
41MP0010678_abnormal_skin_adnexa1.18565919
42MP0005275_abnormal_skin_tensile1.18371417
43MP0008569_lethality_at_weaning1.15982130
44MP0002133_abnormal_respiratory_system1.13098526
45MP0005388_respiratory_system_phenotype1.13098526
46MP0003329_amyloid_beta_deposits1.12803089
47MP0000427_abnormal_hair_cycle1.12594256
48MP0002063_abnormal_learning/memory/cond1.12125317
49MP0002006_tumorigenesis1.11348253
50MP0001501_abnormal_sleep_pattern1.07993260
51MP0008961_abnormal_basal_metabolism1.07434380
52MP0000778_abnormal_nervous_system1.06766922
53MP0004924_abnormal_behavior1.04322811
54MP0005386_behavior/neurological_phenoty1.04322811
55MP0004381_abnormal_hair_follicle1.02477500
56MP0002064_seizures1.01900227
57MP0000015_abnormal_ear_pigmentation1.01790478
58MP0004883_abnormal_blood_vessel1.00276593
59MP0005423_abnormal_somatic_nervous0.99526344
60MP0003950_abnormal_plasma_membrane0.98770200
61MP0004510_myositis0.97900586
62MP0003656_abnormal_erythrocyte_physiolo0.96522399
63MP0001915_intracranial_hemorrhage0.93606714
64MP0002067_abnormal_sensory_capabilities0.93358056
65MP0002909_abnormal_adrenal_gland0.93125436
66MP0001299_abnormal_eye_distance/0.92053723
67MP0003303_peritoneal_inflammation0.91918982
68MP0001440_abnormal_grooming_behavior0.91407747
69MP0009046_muscle_twitch0.91233023
70MP0000465_gastrointestinal_hemorrhage0.90188447
71MP0003890_abnormal_embryonic-extraembry0.87765363
72MP0000733_abnormal_muscle_development0.87084226
73MP0002396_abnormal_hematopoietic_system0.85182426
74MP0003221_abnormal_cardiomyocyte_apopto0.84631144
75MP0003634_abnormal_glial_cell0.83653605
76MP0004215_abnormal_myocardial_fiber0.83269857
77MP0005620_abnormal_muscle_contractility0.81543993
78MP0003866_abnormal_defecation0.81506795
79MP0010630_abnormal_cardiac_muscle0.81303864
80MP0009115_abnormal_fat_cell0.80005836
81MP0002108_abnormal_muscle_morphology0.79762462
82MP0004087_abnormal_muscle_fiber0.77916316
83MP0005076_abnormal_cell_differentiation0.77849885
84MP0002127_abnormal_cardiovascular_syste0.77807172
85MP0004134_abnormal_chest_morphology0.77408962
86MP0000604_amyloidosis0.76439577
87MP0006138_congestive_heart_failure0.75985078
88MP0004808_abnormal_hematopoietic_stem0.75905886
89MP0005187_abnormal_penis_morphology0.75587206
90MP0002998_abnormal_bone_remodeling0.73932109
91MP0000428_abnormal_craniofacial_morphol0.73589604
92MP0002734_abnormal_mechanical_nocicepti0.73459555
93MP0002822_catalepsy0.73370877
94MP0000371_diluted_coat_color0.72957295
95MP0004811_abnormal_neuron_physiology0.72760726
96MP0002971_abnormal_brown_adipose0.72708127
97MP0008877_abnormal_DNA_methylation0.71633847
98MP0001879_abnormal_lymphatic_vessel0.69954834
99MP0003121_genomic_imprinting0.69933579
100MP0009745_abnormal_behavioral_response0.69510807

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.30122166
2Febrile seizures (HP:0002373)2.99251800
3Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.99090536
4Subacute progressive viral hepatitis (HP:0006572)2.80219429
5Overgrowth (HP:0001548)2.79569139
6Difficulty running (HP:0009046)2.76930756
7Abnormality of the fingertips (HP:0001211)2.76395455
8Scanning speech (HP:0002168)2.67520045
9Genetic anticipation (HP:0003743)2.66220031
10Dysmetric saccades (HP:0000641)2.57234819
11T lymphocytopenia (HP:0005403)2.55378456
12Hyperventilation (HP:0002883)2.53513477
13Postural instability (HP:0002172)2.38053820
14Thyroid carcinoma (HP:0002890)2.37356514
15Gaze-evoked nystagmus (HP:0000640)2.35088602
16Arterial tortuosity (HP:0005116)2.30959567
17Action tremor (HP:0002345)2.27086642
18Narrow palate (HP:0000189)2.26676492
19Progressive cerebellar ataxia (HP:0002073)2.23162784
20Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.22313656
21Degeneration of the lateral corticospinal tracts (HP:0002314)2.22313656
22Abnormality of the left ventricular outflow tract (HP:0011103)2.22212767
23Subaortic stenosis (HP:0001682)2.22212767
24Urinary bladder sphincter dysfunction (HP:0002839)2.19875035
25Papilledema (HP:0001085)2.18836983
26Abnormality of T cell number (HP:0011839)2.17033133
27Heterotopia (HP:0002282)2.15717676
28Truncal obesity (HP:0001956)2.15639426
29Aortic aneurysm (HP:0004942)2.12208562
30Macroorchidism (HP:0000053)2.10390524
31Spontaneous hematomas (HP:0007420)2.08272635
32Blue irides (HP:0000635)2.07115746
33Vertebral arch anomaly (HP:0008438)2.06305557
34Acute myeloid leukemia (HP:0004808)2.05664467
35Abnormality of the corticospinal tract (HP:0002492)2.04827171
36Focal seizures (HP:0007359)2.04048802
37Vascular tortuosity (HP:0004948)2.03327810
38Drooling (HP:0002307)2.02632106
39Gingivitis (HP:0000230)2.02512741
40Hepatoblastoma (HP:0002884)1.99759941
41Excessive salivation (HP:0003781)1.99515060
42Abnormality of incisor morphology (HP:0011063)1.99469757
43Atonic seizures (HP:0010819)1.99044259
44Lower limb muscle weakness (HP:0007340)1.96869696
45Absent frontal sinuses (HP:0002688)1.96487756
46Fair hair (HP:0002286)1.93208338
47Hyperkalemia (HP:0002153)1.88848229
48Generalized hypopigmentation of hair (HP:0011358)1.88704975
49Short chin (HP:0000331)1.87229626
50Hyporeflexia of lower limbs (HP:0002600)1.86465140
51Widely spaced teeth (HP:0000687)1.83126123
52Hemiplegia (HP:0002301)1.82936493
53Eczematoid dermatitis (HP:0000976)1.81852139
54Protruding tongue (HP:0010808)1.81137681
55Focal motor seizures (HP:0011153)1.80559850
56Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.80352275
57Germ cell neoplasia (HP:0100728)1.80332638
58Abnormality of the ischium (HP:0003174)1.79225038
59Mitral valve prolapse (HP:0001634)1.78040192
60Limited hip movement (HP:0008800)1.77317133
61Aqueductal stenosis (HP:0002410)1.76351740
62Impaired vibratory sensation (HP:0002495)1.75547391
63Neonatal hypoglycemia (HP:0001998)1.75277504
64Recurrent bacterial skin infections (HP:0005406)1.73632129
65Deeply set eye (HP:0000490)1.66114430
66Periodontitis (HP:0000704)1.65147319
67Tapered finger (HP:0001182)1.62993485
68Sandal gap (HP:0001852)1.62939734
69Thickened helices (HP:0000391)1.62678330
70Vitreoretinal degeneration (HP:0000655)1.61875966
71Aortic dissection (HP:0002647)1.61307854
72Hematochezia (HP:0002573)1.61068347
73Truncal ataxia (HP:0002078)1.61043132
74Dislocated radial head (HP:0003083)1.60500575
75Large earlobe (HP:0009748)1.59396273
76Cubitus valgus (HP:0002967)1.58753905
77Relative macrocephaly (HP:0004482)1.58690725
78Bundle branch block (HP:0011710)1.58690652
79Laryngomalacia (HP:0001601)1.58278391
80Short 4th metacarpal (HP:0010044)1.58187171
81Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.58187171
82Curly hair (HP:0002212)1.57581292
83Pheochromocytoma (HP:0002666)1.57566128
84Onion bulb formation (HP:0003383)1.56774299
85Neoplasm of the heart (HP:0100544)1.55503177
86Spastic gait (HP:0002064)1.55143682
87Conjunctival telangiectasia (HP:0000524)1.55041901
88Hypoplasia of the iris (HP:0007676)1.54957613
89Thyroiditis (HP:0100646)1.54866265
90Impaired vibration sensation in the lower limbs (HP:0002166)1.54801405
91Gingival bleeding (HP:0000225)1.54585854
92Broad ribs (HP:0000885)1.54133487
93Thoracolumbar scoliosis (HP:0002944)1.53796679
94Stomach cancer (HP:0012126)1.53705055
95Cerebral aneurysm (HP:0004944)1.52947279
96Abnormal glucose tolerance (HP:0001952)1.52406353
97Frequent falls (HP:0002359)1.51863173
98Colitis (HP:0002583)1.51850470
99Peritonitis (HP:0002586)1.51398098
100Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.50662352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK2.51406982
2SGK22.36835435
3AKT32.35526379
4OBSCN2.12626905
5WNK12.00727958
6FGFR31.98809602
7SGK31.84801587
8CAMK1G1.76301047
9FGFR21.72867227
10CASK1.69022616
11SGK4941.63830898
12SGK2231.63830898
13PIK3CG1.63132014
14CDK121.58822971
15JAK11.57509199
16NTRK31.56532693
17MAP3K21.56049665
18BLK1.51623661
19LATS11.49052983
20RIPK41.46300707
21BRD41.42933147
22PKN21.42822427
23MARK11.38215587
24NLK1.37743552
25CAMK1D1.36212076
26MARK21.33211498
27RET1.29969239
28MAP3K61.25732199
29CAMKK21.21834262
30MAP3K71.19574922
31EPHA41.18489508
32NTRK21.18318124
33TRPM71.15508975
34MAP3K41.15165847
35PDGFRB1.14117860
36EPHA31.08846502
37STK381.06119678
38MAP3K101.05440344
39YES11.02479511
40PDGFRA1.00222970
41JAK20.95602309
42SGK10.95596151
43PIK3CA0.95370315
44CAMK40.94364085
45DMPK0.92210669
46FES0.90144580
47ACVR1B0.89442905
48MAP2K40.88288614
49FGFR40.86628873
50BMPR20.86357134
51STK38L0.85726195
52KSR20.84588778
53PTK2B0.82691272
54PNCK0.82574579
55RIPK10.81416012
56JAK30.80367165
57STK390.79516105
58TTN0.79485386
59NEK60.78825669
60KSR10.78767370
61STK110.77606816
62MAPK70.76960008
63ERBB20.76387626
64TYK20.74402336
65CSK0.73635993
66CAMKK10.72740225
67DYRK1A0.71946578
68TAOK30.71327549
69TNIK0.70901185
70MAPK120.70334695
71FGR0.70267343
72PDK10.69288820
73MAP3K130.68613055
74TEC0.67582276
75PAK30.67242286
76BTK0.67189475
77SYK0.66239050
78HCK0.66110671
79IKBKE0.64507768
80TGFBR20.63781513
81PRKAA20.63520779
82IRAK10.63057834
83CAMK10.62861834
84NEK90.62266443
85OXSR10.59319361
86PRPF4B0.59040435
87MAPK100.58860259
88ZAP700.58079174
89MELK0.57106011
90FER0.56346456
91ITK0.53999822
92MAP2K30.53428203
93CDK50.53353136
94UHMK10.53109838
95TYRO30.52494804
96CDK60.51851085
97RAF10.50141863
98FGFR10.49990822
99LCK0.49042105
100FYN0.47795787

Predicted pathways (KEGG)

RankGene SetZ-score
1Phosphatidylinositol signaling system_Homo sapiens_hsa040701.78216741
2Dorso-ventral axis formation_Homo sapiens_hsa043201.71555680
3Long-term potentiation_Homo sapiens_hsa047201.70650984
4Inositol phosphate metabolism_Homo sapiens_hsa005621.46300601
5Non-small cell lung cancer_Homo sapiens_hsa052231.42190665
6Endometrial cancer_Homo sapiens_hsa052131.37983450
7Circadian rhythm_Homo sapiens_hsa047101.35998746
8Renin secretion_Homo sapiens_hsa049241.28769606
9Glioma_Homo sapiens_hsa052141.27287715
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24234172
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22896939
12Prolactin signaling pathway_Homo sapiens_hsa049171.22533340
13B cell receptor signaling pathway_Homo sapiens_hsa046621.22476096
14ErbB signaling pathway_Homo sapiens_hsa040121.22047812
15Choline metabolism in cancer_Homo sapiens_hsa052311.21393724
16GnRH signaling pathway_Homo sapiens_hsa049121.20343196
17Renal cell carcinoma_Homo sapiens_hsa052111.20280077
18Platelet activation_Homo sapiens_hsa046111.19640320
19mTOR signaling pathway_Homo sapiens_hsa041501.18273262
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17887147
21Phospholipase D signaling pathway_Homo sapiens_hsa040721.16292688
22Circadian entrainment_Homo sapiens_hsa047131.15541603
23Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15021856
24Glutamatergic synapse_Homo sapiens_hsa047241.14996227
25Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14723150
26FoxO signaling pathway_Homo sapiens_hsa040681.12881927
27Type II diabetes mellitus_Homo sapiens_hsa049301.11951459
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11490677
29Cholinergic synapse_Homo sapiens_hsa047251.11204095
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09391106
31cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08679207
32Osteoclast differentiation_Homo sapiens_hsa043801.07404558
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.07205721
34Oxytocin signaling pathway_Homo sapiens_hsa049211.05306511
35Adherens junction_Homo sapiens_hsa045201.04657219
36Estrogen signaling pathway_Homo sapiens_hsa049151.04314205
37T cell receptor signaling pathway_Homo sapiens_hsa046601.04036356
38Long-term depression_Homo sapiens_hsa047301.03984285
39Pancreatic cancer_Homo sapiens_hsa052121.03806788
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02354364
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01112979
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00665712
43Chronic myeloid leukemia_Homo sapiens_hsa052201.00616686
44Amphetamine addiction_Homo sapiens_hsa050311.00406366
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.99470908
46Focal adhesion_Homo sapiens_hsa045100.98778760
47Gastric acid secretion_Homo sapiens_hsa049710.97739481
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97660154
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96283842
50Colorectal cancer_Homo sapiens_hsa052100.96124411
51cAMP signaling pathway_Homo sapiens_hsa040240.95437051
52VEGF signaling pathway_Homo sapiens_hsa043700.93163226
53Dilated cardiomyopathy_Homo sapiens_hsa054140.91806444
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91442565
55Insulin secretion_Homo sapiens_hsa049110.91359795
56Nicotine addiction_Homo sapiens_hsa050330.91239856
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.90120423
58Calcium signaling pathway_Homo sapiens_hsa040200.89467153
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88821944
60Salivary secretion_Homo sapiens_hsa049700.88179192
61Prostate cancer_Homo sapiens_hsa052150.88176990
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87416476
63Acute myeloid leukemia_Homo sapiens_hsa052210.86818868
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86058704
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.85708723
66Morphine addiction_Homo sapiens_hsa050320.84898962
67Dopaminergic synapse_Homo sapiens_hsa047280.84753294
68Gap junction_Homo sapiens_hsa045400.83141681
69Insulin resistance_Homo sapiens_hsa049310.83082184
70Leishmaniasis_Homo sapiens_hsa051400.82558698
71Pancreatic secretion_Homo sapiens_hsa049720.80459661
72Amoebiasis_Homo sapiens_hsa051460.80015488
73Rap1 signaling pathway_Homo sapiens_hsa040150.78472924
74GABAergic synapse_Homo sapiens_hsa047270.77865807
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77659064
76MAPK signaling pathway_Homo sapiens_hsa040100.77059858
77Proteoglycans in cancer_Homo sapiens_hsa052050.76744138
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76041136
79Ras signaling pathway_Homo sapiens_hsa040140.75182464
80Toxoplasmosis_Homo sapiens_hsa051450.73473938
81MicroRNAs in cancer_Homo sapiens_hsa052060.73323559
82Chemokine signaling pathway_Homo sapiens_hsa040620.72884519
83ABC transporters_Homo sapiens_hsa020100.72832815
84Insulin signaling pathway_Homo sapiens_hsa049100.72388146
85Taste transduction_Homo sapiens_hsa047420.71760482
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.70045224
87Axon guidance_Homo sapiens_hsa043600.68309653
88Lysine degradation_Homo sapiens_hsa003100.68039473
89ECM-receptor interaction_Homo sapiens_hsa045120.66968720
90Small cell lung cancer_Homo sapiens_hsa052220.66903324
91Thyroid hormone synthesis_Homo sapiens_hsa049180.65000245
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.64326529
93Cocaine addiction_Homo sapiens_hsa050300.64324414
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63702511
95Tuberculosis_Homo sapiens_hsa051520.62238681
96Glucagon signaling pathway_Homo sapiens_hsa049220.61578224
97Serotonergic synapse_Homo sapiens_hsa047260.61318532
98Fatty acid biosynthesis_Homo sapiens_hsa000610.59500903
99Melanogenesis_Homo sapiens_hsa049160.58446218
100TNF signaling pathway_Homo sapiens_hsa046680.57395667

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »