KIAA1024L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.98944081
2DNA deamination (GO:0045006)4.60795281
3L-fucose catabolic process (GO:0042355)4.52900337
4fucose catabolic process (GO:0019317)4.52900337
5L-fucose metabolic process (GO:0042354)4.52900337
6negative regulation of telomere maintenance (GO:0032205)3.84118860
7protein polyglutamylation (GO:0018095)3.79824904
8axoneme assembly (GO:0035082)3.55228501
9cytidine deamination (GO:0009972)3.53980163
10cytidine metabolic process (GO:0046087)3.53980163
11cytidine catabolic process (GO:0006216)3.53980163
12sulfation (GO:0051923)3.50633932
13tryptophan catabolic process (GO:0006569)3.49456532
14indole-containing compound catabolic process (GO:0042436)3.49456532
15indolalkylamine catabolic process (GO:0046218)3.49456532
16detection of light stimulus involved in sensory perception (GO:0050962)3.46414712
17detection of light stimulus involved in visual perception (GO:0050908)3.46414712
18cell proliferation in forebrain (GO:0021846)3.46308723
19water-soluble vitamin biosynthetic process (GO:0042364)3.40622653
20negative regulation of mast cell activation (GO:0033004)3.38344337
21kynurenine metabolic process (GO:0070189)3.34650393
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.29435030
23indolalkylamine metabolic process (GO:0006586)3.29007382
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.20777868
25otic vesicle formation (GO:0030916)3.20366586
26response to pheromone (GO:0019236)3.20144371
27neuronal action potential (GO:0019228)3.17437438
28pyrimidine ribonucleoside catabolic process (GO:0046133)3.13941135
29tryptophan metabolic process (GO:0006568)3.02376802
30detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.02066789
31platelet dense granule organization (GO:0060155)3.01118351
32preassembly of GPI anchor in ER membrane (GO:0016254)3.00294881
33nephron tubule morphogenesis (GO:0072078)2.93342584
34nephron epithelium morphogenesis (GO:0072088)2.93342584
35epithelial cilium movement (GO:0003351)2.93192312
36protein complex biogenesis (GO:0070271)2.91322740
37photoreceptor cell development (GO:0042461)2.90168473
38mitochondrial respiratory chain complex I assembly (GO:0032981)2.89929932
39NADH dehydrogenase complex assembly (GO:0010257)2.89929932
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89929932
41cellular ketone body metabolic process (GO:0046950)2.87243345
42negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.86454798
43cellular response to ATP (GO:0071318)2.85559059
44kidney morphogenesis (GO:0060993)2.84224361
45synaptic transmission, cholinergic (GO:0007271)2.83966052
46amine catabolic process (GO:0009310)2.81522242
47cellular biogenic amine catabolic process (GO:0042402)2.81522242
48piRNA metabolic process (GO:0034587)2.74470793
49regulation of mesoderm development (GO:2000380)2.74249889
50positive regulation of defense response to virus by host (GO:0002230)2.72438449
51base-excision repair, AP site formation (GO:0006285)2.70792671
52negative regulation of synaptic transmission, GABAergic (GO:0032229)2.69658146
53gamma-aminobutyric acid transport (GO:0015812)2.67305419
54positive regulation of cAMP-mediated signaling (GO:0043950)2.67177413
55adaptation of signaling pathway (GO:0023058)2.66300606
56transmission of nerve impulse (GO:0019226)2.65798161
57regulation of action potential (GO:0098900)2.64804292
58mannosylation (GO:0097502)2.62450180
59eye photoreceptor cell development (GO:0042462)2.60965426
60somite development (GO:0061053)2.60829417
61protein neddylation (GO:0045116)2.60785685
62GPI anchor metabolic process (GO:0006505)2.59365585
63mitochondrial respiratory chain complex assembly (GO:0033108)2.58653570
64parturition (GO:0007567)2.58251939
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.56806552
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.56806552
67indole-containing compound metabolic process (GO:0042430)2.56401376
68regulation of rhodopsin mediated signaling pathway (GO:0022400)2.55053098
69pyrimidine nucleobase catabolic process (GO:0006208)2.54577176
70ketone body metabolic process (GO:1902224)2.53479243
71primary amino compound metabolic process (GO:1901160)2.52635534
72pharyngeal system development (GO:0060037)2.52553715
73rhodopsin mediated signaling pathway (GO:0016056)2.50839294
74regulation of telomere maintenance (GO:0032204)2.50774950
75head development (GO:0060322)2.47760289
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.47234387
77mesonephros development (GO:0001823)2.45443291
78cilium movement (GO:0003341)2.43889304
79positive regulation of meiosis (GO:0045836)2.43242921
80regulation of cilium movement (GO:0003352)2.43047795
81positive regulation of fatty acid transport (GO:2000193)2.42802314
82retinal cone cell development (GO:0046549)2.41977643
83protein-cofactor linkage (GO:0018065)2.41803372
84limb bud formation (GO:0060174)2.38085831
85behavioral response to ethanol (GO:0048149)2.37710597
86endoderm formation (GO:0001706)2.37695383
87negative regulation of systemic arterial blood pressure (GO:0003085)2.37229970
88DNA methylation involved in gamete generation (GO:0043046)2.36838520
89adenosine metabolic process (GO:0046085)2.36386183
90rRNA catabolic process (GO:0016075)2.36208513
91respiratory chain complex IV assembly (GO:0008535)2.35976147
92positive regulation of fatty acid oxidation (GO:0046321)2.35377983
93protein localization to cilium (GO:0061512)2.33610663
94reflex (GO:0060004)2.32500332
95ATP synthesis coupled proton transport (GO:0015986)2.32435523
96energy coupled proton transport, down electrochemical gradient (GO:0015985)2.32435523
97positive regulation of gastrulation (GO:2000543)2.32419053
98neural tube formation (GO:0001841)2.32232546
99nonmotile primary cilium assembly (GO:0035058)2.31238157
100photoreceptor cell maintenance (GO:0045494)2.29310315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.15035241
2ZNF274_21170338_ChIP-Seq_K562_Hela3.55435367
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.39852801
4VDR_22108803_ChIP-Seq_LS180_Human3.08554723
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.84622822
6GBX2_23144817_ChIP-Seq_PC3_Human2.79653039
7IGF1R_20145208_ChIP-Seq_DFB_Human2.38895049
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36916141
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30912644
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21191384
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07562791
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03225934
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.00505816
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90401444
15EWS_26573619_Chip-Seq_HEK293_Human1.88623446
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88370059
17ER_23166858_ChIP-Seq_MCF-7_Human1.83270192
18P300_19829295_ChIP-Seq_ESCs_Human1.82102087
19TAF15_26573619_Chip-Seq_HEK293_Human1.77507921
20FUS_26573619_Chip-Seq_HEK293_Human1.76525647
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74936123
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74880225
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.70122606
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.67804918
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67299920
26BCAT_22108803_ChIP-Seq_LS180_Human1.64869479
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.63702985
28AR_21572438_ChIP-Seq_LNCaP_Human1.57097920
29IRF1_19129219_ChIP-ChIP_H3396_Human1.56509414
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56508990
31REST_21632747_ChIP-Seq_MESCs_Mouse1.54522387
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53921211
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53764627
34TP53_22573176_ChIP-Seq_HFKS_Human1.50381316
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45794370
36CBP_20019798_ChIP-Seq_JUKART_Human1.44974868
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44974868
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44802412
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38609129
40AR_25329375_ChIP-Seq_VCAP_Human1.36949597
41RNF2_27304074_Chip-Seq_NSC_Mouse1.36652249
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36227076
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36227020
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34073890
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.33596903
46NANOG_19829295_ChIP-Seq_ESCs_Human1.32251103
47SOX2_19829295_ChIP-Seq_ESCs_Human1.32251103
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32034480
49STAT3_23295773_ChIP-Seq_U87_Human1.30991604
50SMAD4_21799915_ChIP-Seq_A2780_Human1.30517491
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29860220
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.29403478
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29403478
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29237674
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28146756
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.27432751
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27282214
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.27124807
59NCOR_22424771_ChIP-Seq_293T_Human1.26402345
60MYC_18940864_ChIP-ChIP_HL60_Human1.26253129
61TCF4_23295773_ChIP-Seq_U87_Human1.24909416
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24280180
63TCF4_22108803_ChIP-Seq_LS180_Human1.22774301
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22076716
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19763970
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19720774
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17623911
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17623911
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17396396
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17278555
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16611844
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16478812
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.15982946
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15115822
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14903726
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.14510502
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13901249
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.13663251
79HOXB7_26014856_ChIP-Seq_BT474_Human1.13366950
80GABP_17652178_ChIP-ChIP_JURKAT_Human1.12025853
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11324766
82RUNX2_22187159_ChIP-Seq_PCA_Human1.11241759
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.10434170
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09826508
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09415334
86AR_20517297_ChIP-Seq_VCAP_Human1.08016553
87JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07600433
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.06218662
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06065339
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04813739
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.03169473
92EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02542276
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01866989
94TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01726259
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.00832514
96FOXH1_21741376_ChIP-Seq_EPCs_Human0.98924900
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98900445
98SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96454311
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96190034
100REST_18959480_ChIP-ChIP_MESCs_Mouse0.95972658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.69185456
2MP0000569_abnormal_digit_pigmentation2.49151697
3MP0001968_abnormal_touch/_nociception2.43610135
4MP0005551_abnormal_eye_electrophysiolog2.41858732
5MP0006292_abnormal_olfactory_placode2.36512675
6MP0002837_dystrophic_cardiac_calcinosis2.33412052
7MP0003880_abnormal_central_pattern2.30164970
8MP0002160_abnormal_reproductive_system2.29369840
9MP0005646_abnormal_pituitary_gland2.25452574
10MP0002736_abnormal_nociception_after2.23077925
11MP0002138_abnormal_hepatobiliary_system2.17879494
12MP0003787_abnormal_imprinting2.14252983
13MP0004885_abnormal_endolymph2.12748796
14MP0002102_abnormal_ear_morphology2.12040015
15MP0005083_abnormal_biliary_tract2.03074195
16MP0002653_abnormal_ependyma_morphology2.02018661
17MP0008872_abnormal_physiological_respon1.99751513
18MP0002876_abnormal_thyroid_physiology1.98875379
19MP0003195_calcinosis1.98860982
20MP0006072_abnormal_retinal_apoptosis1.92645854
21MP0004147_increased_porphyrin_level1.88469272
22MP0005389_reproductive_system_phenotype1.87825848
23MP0009745_abnormal_behavioral_response1.71193635
24MP0004142_abnormal_muscle_tone1.69381899
25MP0001986_abnormal_taste_sensitivity1.68392199
26MP0005084_abnormal_gallbladder_morpholo1.67676942
27MP0004043_abnormal_pH_regulation1.65936550
28MP0009046_muscle_twitch1.64938828
29MP0000631_abnormal_neuroendocrine_gland1.64368065
30MP0002272_abnormal_nervous_system1.62415098
31MP0008875_abnormal_xenobiotic_pharmacok1.61390524
32MP0005253_abnormal_eye_physiology1.60875639
33MP0002638_abnormal_pupillary_reflex1.59154779
34MP0002928_abnormal_bile_duct1.58591267
35MP0003011_delayed_dark_adaptation1.58341582
36MP0005645_abnormal_hypothalamus_physiol1.56069156
37MP0006276_abnormal_autonomic_nervous1.50420132
38MP0002938_white_spotting1.48439805
39MP0002735_abnormal_chemical_nociception1.48258368
40MP0001486_abnormal_startle_reflex1.43611298
41MP0002733_abnormal_thermal_nociception1.42833701
42MP0002234_abnormal_pharynx_morphology1.42713644
43MP0004133_heterotaxia1.40828417
44MP0003283_abnormal_digestive_organ1.38010689
45MP0003136_yellow_coat_color1.37618304
46MP0005671_abnormal_response_to1.35441005
47MP0001970_abnormal_pain_threshold1.32005623
48MP0001485_abnormal_pinna_reflex1.31881322
49MP0004742_abnormal_vestibular_system1.30177055
50MP0002163_abnormal_gland_morphology1.28893168
51MP0005174_abnormal_tail_pigmentation1.28667251
52MP0003646_muscle_fatigue1.27854499
53MP0002572_abnormal_emotion/affect_behav1.24095364
54MP0000427_abnormal_hair_cycle1.23059518
55MP0002557_abnormal_social/conspecific_i1.21697679
56MP0000049_abnormal_middle_ear1.20722379
57MP0002064_seizures1.19660307
58MP0001919_abnormal_reproductive_system1.17950115
59MP0000372_irregular_coat_pigmentation1.16777963
60MP0001501_abnormal_sleep_pattern1.12076921
61MP0004145_abnormal_muscle_electrophysio1.08691787
62MP0003121_genomic_imprinting1.03484351
63MP0003635_abnormal_synaptic_transmissio1.02361494
64MP0002822_catalepsy1.00089641
65MP0001984_abnormal_olfaction1.00052768
66MP0005195_abnormal_posterior_eye0.98974459
67MP0003252_abnormal_bile_duct0.98339224
68MP0005423_abnormal_somatic_nervous0.97664134
69MP0002063_abnormal_learning/memory/cond0.97050051
70MP0000026_abnormal_inner_ear0.96967189
71MP0002734_abnormal_mechanical_nocicepti0.96866602
72MP0002254_reproductive_system_inflammat0.95963904
73MP0010386_abnormal_urinary_bladder0.95462033
74MP0002067_abnormal_sensory_capabilities0.94012173
75MP0005379_endocrine/exocrine_gland_phen0.93901894
76MP0004924_abnormal_behavior0.93238053
77MP0005386_behavior/neurological_phenoty0.93238053
78MP0003890_abnormal_embryonic-extraembry0.92201020
79MP0000383_abnormal_hair_follicle0.91869438
80MP0001905_abnormal_dopamine_level0.91215387
81MP0005085_abnormal_gallbladder_physiolo0.90559182
82MP0002184_abnormal_innervation0.90369324
83MP0001529_abnormal_vocalization0.87833024
84MP0003122_maternal_imprinting0.87575613
85MP0002752_abnormal_somatic_nervous0.86923713
86MP0001963_abnormal_hearing_physiology0.86869585
87MP0008995_early_reproductive_senescence0.85211507
88MP0000230_abnormal_systemic_arterial0.83725812
89MP0000613_abnormal_salivary_gland0.83499992
90MP0000778_abnormal_nervous_system0.82536267
91MP0002693_abnormal_pancreas_physiology0.80623029
92MP0003137_abnormal_impulse_conducting0.79722771
93MP0003119_abnormal_digestive_system0.78324780
94MP0001440_abnormal_grooming_behavior0.77491607
95MP0002751_abnormal_autonomic_nervous0.77487830
96MP0002095_abnormal_skin_pigmentation0.77460999
97MP0005075_abnormal_melanosome_morpholog0.77010812
98MP0005377_hearing/vestibular/ear_phenot0.75321919
99MP0003878_abnormal_ear_physiology0.75321919
100MP0001502_abnormal_circadian_rhythm0.74828680

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.94373819
2Pancreatic fibrosis (HP:0100732)4.69393276
3True hermaphroditism (HP:0010459)4.65388611
4Absent rod-and cone-mediated responses on ERG (HP:0007688)3.99666648
5Congenital stationary night blindness (HP:0007642)3.96208828
6Pendular nystagmus (HP:0012043)3.88133385
7Molar tooth sign on MRI (HP:0002419)3.83247136
8Abnormality of midbrain morphology (HP:0002418)3.83247136
9Abnormal rod and cone electroretinograms (HP:0008323)3.64988734
10Nephronophthisis (HP:0000090)3.51264296
11Abolished electroretinogram (ERG) (HP:0000550)3.49018305
12Attenuation of retinal blood vessels (HP:0007843)3.25661509
13Cystic liver disease (HP:0006706)3.20187425
14Decreased central vision (HP:0007663)3.19222655
15Keratoconus (HP:0000563)3.07002751
16Increased corneal curvature (HP:0100692)3.07002751
17Abnormality of the renal medulla (HP:0100957)2.97500985
18Medial flaring of the eyebrow (HP:0010747)2.91986015
19Severe visual impairment (HP:0001141)2.89965988
20Sclerocornea (HP:0000647)2.87861390
21Abnormality of the renal cortex (HP:0011035)2.85269362
22Hyperventilation (HP:0002883)2.66209075
23Type II lissencephaly (HP:0007260)2.54833976
24Gait imbalance (HP:0002141)2.50970583
25Aplasia/Hypoplasia of the tongue (HP:0010295)2.47075750
26Anencephaly (HP:0002323)2.46046813
27Chronic hepatic failure (HP:0100626)2.43004791
28Male pseudohermaphroditism (HP:0000037)2.42170778
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.40403312
30Absent/shortened dynein arms (HP:0200106)2.40403312
31Congenital primary aphakia (HP:0007707)2.34917224
32Aplasia/Hypoplasia of the spleen (HP:0010451)2.32243482
33Postaxial foot polydactyly (HP:0001830)2.31801603
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.31435582
35Congenital hepatic fibrosis (HP:0002612)2.28192758
36Asplenia (HP:0001746)2.26022094
37Congenital, generalized hypertrichosis (HP:0004540)2.25879333
38Nephrogenic diabetes insipidus (HP:0009806)2.25097133
39Tubular atrophy (HP:0000092)2.19538881
40Abnormal drinking behavior (HP:0030082)2.17721232
41Polydipsia (HP:0001959)2.17721232
42Furrowed tongue (HP:0000221)2.14198813
43Methylmalonic acidemia (HP:0002912)2.13419576
44Progressive cerebellar ataxia (HP:0002073)2.10531169
45Abnormal albumin level (HP:0012116)2.09829951
46Hypoalbuminemia (HP:0003073)2.09829951
47Large for gestational age (HP:0001520)2.07745700
48Renal cortical cysts (HP:0000803)2.05784935
493-Methylglutaconic aciduria (HP:0003535)2.04001062
50Conical tooth (HP:0000698)2.03843463
51Genital tract atresia (HP:0001827)2.03758864
52Mitochondrial inheritance (HP:0001427)2.03245512
53Pachygyria (HP:0001302)2.02447999
54Abnormal respiratory motile cilium morphology (HP:0005938)2.01785781
55Abnormal respiratory epithelium morphology (HP:0012253)2.01785781
56Postaxial hand polydactyly (HP:0001162)2.01107579
57Vaginal atresia (HP:0000148)2.01054826
58Methylmalonic aciduria (HP:0012120)2.00760402
59Inability to walk (HP:0002540)2.00133875
60Aplasia/Hypoplasia of the uvula (HP:0010293)1.98479507
61Hypoplastic iliac wings (HP:0002866)1.96141485
62Concave nail (HP:0001598)1.94375977
63Hepatocellular necrosis (HP:0001404)1.93750232
64Small hand (HP:0200055)1.93531562
65Abnormality of the renal collecting system (HP:0004742)1.92817148
66Abnormal biliary tract physiology (HP:0012439)1.91593575
67Bile duct proliferation (HP:0001408)1.91593575
68Abnormality of DNA repair (HP:0003254)1.90893371
69Poor coordination (HP:0002370)1.90879834
70Lissencephaly (HP:0001339)1.90381468
71Optic disc pallor (HP:0000543)1.88494884
72Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88401866
73Genetic anticipation (HP:0003743)1.87579013
74Absent thumb (HP:0009777)1.86319252
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85721485
76Abnormality of alanine metabolism (HP:0010916)1.85721485
77Hyperalaninemia (HP:0003348)1.85721485
78Optic nerve hypoplasia (HP:0000609)1.85717005
79Increased CSF lactate (HP:0002490)1.85632436
80Colon cancer (HP:0003003)1.85028863
81Polyuria (HP:0000103)1.84551111
82Aplasia/hypoplasia of the uterus (HP:0008684)1.84534742
83Hypoproteinemia (HP:0003075)1.84393105
84Gaze-evoked nystagmus (HP:0000640)1.82789648
85Abnormality of the pons (HP:0007361)1.78985191
86Abnormal ciliary motility (HP:0012262)1.77897961
87Broad-based gait (HP:0002136)1.77858423
88Hypothermia (HP:0002045)1.76687858
89Hypoplasia of the pons (HP:0012110)1.73601945
90Chorioretinal atrophy (HP:0000533)1.72278255
91Absent speech (HP:0001344)1.71687893
92Oligohydramnios (HP:0001562)1.71248626
93Preaxial hand polydactyly (HP:0001177)1.71153572
94Bony spicule pigmentary retinopathy (HP:0007737)1.71006690
95Abnormal number of erythroid precursors (HP:0012131)1.70734767
96Ectopic kidney (HP:0000086)1.70029700
97Acute necrotizing encephalopathy (HP:0006965)1.69084465
98Hyperglycinemia (HP:0002154)1.68121792
99Hepatic necrosis (HP:0002605)1.67979574
100Constricted visual fields (HP:0001133)1.67867507

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.21817480
2ZAK3.80849151
3ADRBK23.40382072
4GRK13.07967501
5NUAK12.90389516
6TLK12.81958375
7TXK2.61867852
8BCKDK2.44617515
9TAOK32.40227334
10WNK42.36667458
11BMPR1B2.24229738
12CASK2.24044955
13PINK12.09945011
14MAP4K22.09571829
15WNK32.07738080
16ACVR1B1.99006231
17MAP3K41.73096219
18MAPK131.67285798
19INSRR1.66331733
20OXSR11.49902581
21DAPK21.39160523
22VRK11.28247407
23VRK21.26912094
24DYRK21.23205791
25TIE11.22769210
26MAP2K71.19443597
27TNIK1.17311953
28ADRBK11.13107392
29PAK31.12942026
30STK391.12763253
31NME11.09919739
32MARK11.09672495
33MAPK151.08007470
34PRKCG1.06062769
35CAMKK20.97722454
36GRK70.97138854
37PNCK0.94675244
38CSNK1G20.94532582
39PHKG10.94199322
40PHKG20.94199322
41MUSK0.91639737
42PRKCE0.87266235
43PRKCQ0.86396471
44CSNK1G30.86072447
45MST40.85562875
46NTRK20.81552932
47TEC0.79838158
48CSNK1G10.79332160
49CSNK1A1L0.79324806
50NTRK30.79028526
51PIK3CA0.78368188
52IKBKB0.78223555
53ITK0.74820207
54EIF2AK30.73207476
55PLK20.66833656
56CDK190.65744454
57EPHA40.64809911
58PTK2B0.61833606
59GRK50.61249181
60CAMK2A0.60375407
61TRIM280.58318331
62MAP2K60.56880008
63STK38L0.56394652
64PRKCI0.54376588
65ERBB30.53620888
66PRKACA0.53000590
67TNK20.51341263
68RPS6KA50.51319255
69TAF10.51253995
70LATS10.50118364
71MKNK20.50024299
72AKT30.49148289
73PKN10.48405783
74EPHA30.47287252
75MAPKAPK50.46841423
76KIT0.46082289
77CSNK1A10.45581152
78CAMK10.45537668
79KDR0.45258821
80TGFBR10.44050042
81PRKCZ0.43994178
82IRAK10.42651388
83MAP2K20.42046691
84STK110.41673402
85CHEK20.41467051
86EIF2AK20.39823794
87SYK0.38909487
88PRKCA0.38838757
89MAP3K70.37260837
90CSNK1D0.37011825
91PRKCH0.35239642
92CHUK0.34190196
93OBSCN0.34084409
94ABL10.33385977
95NLK0.33352150
96FGFR20.32917229
97MAPKAPK30.32618955
98DYRK30.31397496
99ERBB20.29656007
100IKBKE0.29001681

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.94747768
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.78919824
3Oxidative phosphorylation_Homo sapiens_hsa001902.44765784
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.33919597
5Linoleic acid metabolism_Homo sapiens_hsa005912.27369638
6Nicotine addiction_Homo sapiens_hsa050332.16788836
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.14905773
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12054916
9Nitrogen metabolism_Homo sapiens_hsa009102.07880166
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.07692824
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.05918710
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00851290
13Butanoate metabolism_Homo sapiens_hsa006501.83721377
14Parkinsons disease_Homo sapiens_hsa050121.82272424
15Selenocompound metabolism_Homo sapiens_hsa004501.76234776
16Homologous recombination_Homo sapiens_hsa034401.74441041
17Tryptophan metabolism_Homo sapiens_hsa003801.63312014
18Primary immunodeficiency_Homo sapiens_hsa053401.62791344
19Olfactory transduction_Homo sapiens_hsa047401.61209459
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59004464
21Ether lipid metabolism_Homo sapiens_hsa005651.57811003
22Protein export_Homo sapiens_hsa030601.53110918
23Fanconi anemia pathway_Homo sapiens_hsa034601.51834387
24Propanoate metabolism_Homo sapiens_hsa006401.50408538
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46424433
26RNA polymerase_Homo sapiens_hsa030201.45303028
27Morphine addiction_Homo sapiens_hsa050321.43826131
28Taste transduction_Homo sapiens_hsa047421.38856027
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37803064
30Cardiac muscle contraction_Homo sapiens_hsa042601.36899276
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.34341701
32Caffeine metabolism_Homo sapiens_hsa002321.32712353
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32309788
34Chemical carcinogenesis_Homo sapiens_hsa052041.31571736
35Alzheimers disease_Homo sapiens_hsa050101.29945046
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26745392
37Insulin secretion_Homo sapiens_hsa049111.26472051
38Peroxisome_Homo sapiens_hsa041461.19652169
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16862248
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.15762508
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12699990
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.12205872
43GABAergic synapse_Homo sapiens_hsa047271.12023442
44Huntingtons disease_Homo sapiens_hsa050161.10306133
45Retinol metabolism_Homo sapiens_hsa008301.09923015
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99692819
47Circadian entrainment_Homo sapiens_hsa047130.98631026
48beta-Alanine metabolism_Homo sapiens_hsa004100.97915722
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97810496
50ABC transporters_Homo sapiens_hsa020100.96705229
51Serotonergic synapse_Homo sapiens_hsa047260.96624445
52Regulation of autophagy_Homo sapiens_hsa041400.95783786
53RNA degradation_Homo sapiens_hsa030180.94756441
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93875879
55Basal transcription factors_Homo sapiens_hsa030220.93383735
56Glutamatergic synapse_Homo sapiens_hsa047240.89994859
57One carbon pool by folate_Homo sapiens_hsa006700.88596958
58Arachidonic acid metabolism_Homo sapiens_hsa005900.87648640
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84341356
60Asthma_Homo sapiens_hsa053100.84337615
61Type I diabetes mellitus_Homo sapiens_hsa049400.80838538
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79221197
63Salivary secretion_Homo sapiens_hsa049700.77157205
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76551615
65Graft-versus-host disease_Homo sapiens_hsa053320.76174339
66Systemic lupus erythematosus_Homo sapiens_hsa053220.75929209
67Ovarian steroidogenesis_Homo sapiens_hsa049130.73740731
68Ribosome_Homo sapiens_hsa030100.70728229
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67842362
70Calcium signaling pathway_Homo sapiens_hsa040200.66442308
71Sulfur metabolism_Homo sapiens_hsa009200.64633138
72Histidine metabolism_Homo sapiens_hsa003400.63163389
73Fat digestion and absorption_Homo sapiens_hsa049750.61143287
74Autoimmune thyroid disease_Homo sapiens_hsa053200.61004928
75Proteasome_Homo sapiens_hsa030500.60972095
76Purine metabolism_Homo sapiens_hsa002300.60084335
77Glycerolipid metabolism_Homo sapiens_hsa005610.58842762
78Hedgehog signaling pathway_Homo sapiens_hsa043400.58762589
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58504931
80Allograft rejection_Homo sapiens_hsa053300.58192639
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57852441
82Dopaminergic synapse_Homo sapiens_hsa047280.56232205
83Metabolic pathways_Homo sapiens_hsa011000.54222935
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53302864
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52623044
86Vitamin digestion and absorption_Homo sapiens_hsa049770.51309389
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51233795
88Rheumatoid arthritis_Homo sapiens_hsa053230.51001053
89Steroid biosynthesis_Homo sapiens_hsa001000.50499369
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50406764
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46405575
92Collecting duct acid secretion_Homo sapiens_hsa049660.44872620
93Dorso-ventral axis formation_Homo sapiens_hsa043200.44856863
94Amphetamine addiction_Homo sapiens_hsa050310.44467248
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44069165
96Alcoholism_Homo sapiens_hsa050340.43866737
97Cholinergic synapse_Homo sapiens_hsa047250.41298200
98cAMP signaling pathway_Homo sapiens_hsa040240.39078449
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38329218
100Hematopoietic cell lineage_Homo sapiens_hsa046400.37435581

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