KIAA0895

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)4.31422719
2epithelial cilium movement (GO:0003351)3.71516150
3pyrimidine nucleobase catabolic process (GO:0006208)3.71226205
4cilium movement (GO:0003341)3.55480978
5DNA methylation involved in gamete generation (GO:0043046)3.49510195
6nucleobase catabolic process (GO:0046113)3.40094867
7axonemal dynein complex assembly (GO:0070286)3.38210064
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.34242442
9presynaptic membrane assembly (GO:0097105)3.34210508
10synapsis (GO:0007129)3.33921870
11intraciliary transport (GO:0042073)3.26776383
12nonmotile primary cilium assembly (GO:0035058)3.26044705
13positive regulation of meiosis (GO:0045836)3.23538521
14presynaptic membrane organization (GO:0097090)3.20610685
15regulation of cilium movement (GO:0003352)3.13487909
16regulation of meiosis I (GO:0060631)3.11534192
17positive regulation of meiotic cell cycle (GO:0051446)3.08608039
18male meiosis I (GO:0007141)3.07768752
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.07268140
20male meiosis (GO:0007140)3.07161946
21protein localization to cilium (GO:0061512)3.04791969
22axoneme assembly (GO:0035082)3.03955584
23cilium organization (GO:0044782)3.03847311
24cilium assembly (GO:0042384)3.03531597
25cilium or flagellum-dependent cell motility (GO:0001539)3.03143099
26behavioral response to nicotine (GO:0035095)3.02364565
27negative regulation of cytosolic calcium ion concentration (GO:0051481)3.00874758
28postsynaptic membrane organization (GO:0001941)2.99103149
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.98972387
30cornea development in camera-type eye (GO:0061303)2.85472283
31auditory behavior (GO:0031223)2.82683554
32neuron cell-cell adhesion (GO:0007158)2.79832929
33axonal fasciculation (GO:0007413)2.77134728
34transmission of nerve impulse (GO:0019226)2.76294607
35regulation of microtubule-based movement (GO:0060632)2.76015546
36positive regulation of mitochondrial fission (GO:0090141)2.70351441
37cilium morphogenesis (GO:0060271)2.67766115
38protein polyglutamylation (GO:0018095)2.65400202
39retinal ganglion cell axon guidance (GO:0031290)2.65059836
40protein localization to synapse (GO:0035418)2.64924708
41chromosome organization involved in meiosis (GO:0070192)2.53942702
42limb development (GO:0060173)2.51584647
43appendage development (GO:0048736)2.51584647
44dendritic spine morphogenesis (GO:0060997)2.50653271
45smoothened signaling pathway (GO:0007224)2.49652523
46acrosome reaction (GO:0007340)2.45240212
47left/right pattern formation (GO:0060972)2.43672668
48synapse assembly (GO:0007416)2.41993621
49gamma-aminobutyric acid transport (GO:0015812)2.40275635
50neurofilament cytoskeleton organization (GO:0060052)2.38609859
51neurotransmitter-gated ion channel clustering (GO:0072578)2.38294217
52mechanosensory behavior (GO:0007638)2.37042092
53neuron recognition (GO:0008038)2.36654356
54resolution of meiotic recombination intermediates (GO:0000712)2.35248124
55cellular component assembly involved in morphogenesis (GO:0010927)2.34209249
56calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.32910774
57left/right axis specification (GO:0070986)2.32865631
58microtubule bundle formation (GO:0001578)2.31824168
59brain morphogenesis (GO:0048854)2.31101273
60positive regulation of dendritic spine morphogenesis (GO:0061003)2.29848227
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.29344678
62primary amino compound metabolic process (GO:1901160)2.28897654
63G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.27950643
64response to auditory stimulus (GO:0010996)2.27397988
65hindbrain development (GO:0030902)2.26281526
66spinal cord motor neuron differentiation (GO:0021522)2.25812804
67vocalization behavior (GO:0071625)2.23781588
68regulation of short-term neuronal synaptic plasticity (GO:0048172)2.22995043
69neurotransmitter secretion (GO:0007269)2.22636156
70detection of light stimulus involved in sensory perception (GO:0050962)2.22310885
71detection of light stimulus involved in visual perception (GO:0050908)2.22310885
72dendrite morphogenesis (GO:0048813)2.21738121
73detection of calcium ion (GO:0005513)2.21397124
74meiosis I (GO:0007127)2.20274291
75protein import into peroxisome matrix (GO:0016558)2.19313149
76neural tube formation (GO:0001841)2.19291532
77central nervous system neuron axonogenesis (GO:0021955)2.18908429
78regulation of hexokinase activity (GO:1903299)2.17796837
79regulation of glucokinase activity (GO:0033131)2.17796837
80serotonin metabolic process (GO:0042428)2.17632912
81microtubule depolymerization (GO:0007019)2.17339154
82sperm motility (GO:0030317)2.16855040
83neuron fate specification (GO:0048665)2.16417470
84somite rostral/caudal axis specification (GO:0032525)2.15796045
85negative regulation of synaptic transmission, GABAergic (GO:0032229)2.14958249
86central nervous system projection neuron axonogenesis (GO:0021952)2.14440262
87hippocampus development (GO:0021766)2.14211643
88motile cilium assembly (GO:0044458)2.14151138
89behavioral response to ethanol (GO:0048149)2.13961393
90glutamate receptor signaling pathway (GO:0007215)2.13555773
91positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.12985405
92negative regulation of axon guidance (GO:1902668)2.12682318
93embryonic foregut morphogenesis (GO:0048617)2.12182960
94cerebral cortex radially oriented cell migration (GO:0021799)2.11189710
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.11004655
96neuronal action potential (GO:0019228)2.10383741
97establishment of nucleus localization (GO:0040023)2.09763045
98photoreceptor cell maintenance (GO:0045494)2.09395215
99startle response (GO:0001964)2.09219733
100ubiquinone metabolic process (GO:0006743)2.09171291

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human3.25560413
2GBX2_23144817_ChIP-Seq_PC3_Human3.05806670
3* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.76493795
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.75669002
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.71328886
6ZNF274_21170338_ChIP-Seq_K562_Hela2.62194347
7TAF15_26573619_Chip-Seq_HEK293_Human2.60453939
8FUS_26573619_Chip-Seq_HEK293_Human2.51326019
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49184124
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.37461181
11VDR_22108803_ChIP-Seq_LS180_Human2.33929670
12EZH2_22144423_ChIP-Seq_EOC_Human2.32292498
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.24211411
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.14269362
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.10673563
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04552337
17RNF2_27304074_Chip-Seq_NSC_Mouse2.04227482
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93685706
19* P300_19829295_ChIP-Seq_ESCs_Human1.90585026
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90280259
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88076974
22* SMAD4_21799915_ChIP-Seq_A2780_Human1.80923405
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77965721
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77516009
25EWS_26573619_Chip-Seq_HEK293_Human1.77100780
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71008480
27REST_21632747_ChIP-Seq_MESCs_Mouse1.70034068
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67506194
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.66241537
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65513811
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.61806140
32ER_23166858_ChIP-Seq_MCF-7_Human1.59726701
33* STAT3_23295773_ChIP-Seq_U87_Human1.59032186
34TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51715330
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.51242356
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50944884
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50712369
38AR_25329375_ChIP-Seq_VCAP_Human1.50610143
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.50514826
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48452506
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47748769
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47188384
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45956559
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42358240
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.40103428
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40091909
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37535633
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37125667
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36511172
50RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34725380
51* RUNX2_22187159_ChIP-Seq_PCA_Human1.34618558
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31881005
53TCF4_23295773_ChIP-Seq_U87_Human1.29952837
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27738723
55CBP_20019798_ChIP-Seq_JUKART_Human1.27738723
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25686831
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25181331
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20856952
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19179804
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18340929
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.18070406
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18062909
63* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17890934
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.17838669
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.17470959
66TP53_22573176_ChIP-Seq_HFKS_Human1.16601210
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16439311
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16426414
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.15954905
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14524451
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.14099094
72TCF4_22108803_ChIP-Seq_LS180_Human1.14072148
73* SOX2_21211035_ChIP-Seq_LN229_Gbm1.12950770
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12948634
75BCAT_22108803_ChIP-Seq_LS180_Human1.11861597
76IRF1_19129219_ChIP-ChIP_H3396_Human1.09273704
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.07331014
78AR_21572438_ChIP-Seq_LNCaP_Human1.07254354
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06063811
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06063811
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05714397
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05687411
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03895845
84SOX9_26525672_Chip-Seq_HEART_Mouse1.03626690
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02593639
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02452214
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01481002
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00977269
89JUN_21703547_ChIP-Seq_K562_Human1.00265194
90SOX2_19829295_ChIP-Seq_ESCs_Human0.99674266
91NANOG_19829295_ChIP-Seq_ESCs_Human0.99674266
92* SMAD4_21741376_ChIP-Seq_EPCs_Human0.99474481
93SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99005788
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98823687
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98623406
96HTT_18923047_ChIP-ChIP_STHdh_Human0.97834935
97EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96487552
98RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96487552
99TP53_18474530_ChIP-ChIP_U2OS_Human0.96305178
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96251575

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern2.64962110
2MP0008877_abnormal_DNA_methylation2.53916779
3MP0003122_maternal_imprinting2.29626350
4MP0006292_abnormal_olfactory_placode2.06327458
5MP0009046_muscle_twitch2.05778278
6MP0000778_abnormal_nervous_system2.04474778
7MP0002638_abnormal_pupillary_reflex1.98038120
8MP0000569_abnormal_digit_pigmentation1.94554134
9MP0002938_white_spotting1.93566409
10MP0001984_abnormal_olfaction1.90910597
11MP0005423_abnormal_somatic_nervous1.86630182
12MP0006276_abnormal_autonomic_nervous1.85261652
13MP0003787_abnormal_imprinting1.82302896
14MP0004270_analgesia1.80482393
15MP0002909_abnormal_adrenal_gland1.79353406
16MP0003890_abnormal_embryonic-extraembry1.73366083
17MP0002653_abnormal_ependyma_morphology1.69822226
18MP0002837_dystrophic_cardiac_calcinosis1.69139160
19MP0009745_abnormal_behavioral_response1.67341853
20MP0000566_synostosis1.66814708
21MP0004859_abnormal_synaptic_plasticity1.63798388
22MP0006072_abnormal_retinal_apoptosis1.62714207
23MP0001529_abnormal_vocalization1.62305363
24MP0000631_abnormal_neuroendocrine_gland1.61451527
25MP0002272_abnormal_nervous_system1.60992858
26MP0003635_abnormal_synaptic_transmissio1.59904222
27MP0003121_genomic_imprinting1.58805464
28MP0005253_abnormal_eye_physiology1.54055732
29MP0002572_abnormal_emotion/affect_behav1.50185520
30MP0002557_abnormal_social/conspecific_i1.49188968
31MP0002064_seizures1.47160018
32MP0005551_abnormal_eye_electrophysiolog1.47065439
33MP0002184_abnormal_innervation1.46644960
34MP0004133_heterotaxia1.46301013
35MP0001486_abnormal_startle_reflex1.43521896
36MP0002160_abnormal_reproductive_system1.42366603
37MP0002234_abnormal_pharynx_morphology1.42160608
38MP0002102_abnormal_ear_morphology1.42042078
39MP0002734_abnormal_mechanical_nocicepti1.41127114
40MP0002063_abnormal_learning/memory/cond1.39628586
41MP0005187_abnormal_penis_morphology1.39223871
42MP0008789_abnormal_olfactory_epithelium1.33375948
43MP0000955_abnormal_spinal_cord1.31823086
44MP0002822_catalepsy1.30988452
45MP0001968_abnormal_touch/_nociception1.29489670
46MP0000383_abnormal_hair_follicle1.28955050
47MP0003136_yellow_coat_color1.28605913
48MP0005646_abnormal_pituitary_gland1.27287328
49MP0009780_abnormal_chondrocyte_physiolo1.25957860
50MP0005394_taste/olfaction_phenotype1.24476724
51MP0005499_abnormal_olfactory_system1.24476724
52MP0000647_abnormal_sebaceous_gland1.24277705
53MP0004924_abnormal_behavior1.23873787
54MP0005386_behavior/neurological_phenoty1.23873787
55MP0003937_abnormal_limbs/digits/tail_de1.22982213
56MP0005645_abnormal_hypothalamus_physiol1.22868341
57MP0002735_abnormal_chemical_nociception1.19953418
58MP0001501_abnormal_sleep_pattern1.18404451
59MP0002928_abnormal_bile_duct1.17660514
60MP0003698_abnormal_male_reproductive1.15137496
61MP0001502_abnormal_circadian_rhythm1.14044401
62MP0004885_abnormal_endolymph1.12107741
63MP0002882_abnormal_neuron_morphology1.09048176
64MP0002067_abnormal_sensory_capabilities1.07817544
65MP0003195_calcinosis1.07718647
66MP0001929_abnormal_gametogenesis1.07396166
67MP0005248_abnormal_Harderian_gland1.07126869
68MP0010678_abnormal_skin_adnexa1.05574313
69MP0004142_abnormal_muscle_tone1.05110938
70MP0000427_abnormal_hair_cycle1.04749435
71MP0003119_abnormal_digestive_system1.03020318
72MP0002210_abnormal_sex_determination1.02829819
73MP0002736_abnormal_nociception_after1.01856076
74MP0004043_abnormal_pH_regulation0.99805219
75MP0001970_abnormal_pain_threshold0.97898226
76MP0008875_abnormal_xenobiotic_pharmacok0.97856634
77MP0004147_increased_porphyrin_level0.97110391
78MP0000013_abnormal_adipose_tissue0.96864096
79MP0004811_abnormal_neuron_physiology0.96518306
80MP0010386_abnormal_urinary_bladder0.96225189
81MP0001485_abnormal_pinna_reflex0.95436075
82MP0005391_vision/eye_phenotype0.95404869
83MP0008995_early_reproductive_senescence0.92489776
84MP0002752_abnormal_somatic_nervous0.92129140
85MP0001944_abnormal_pancreas_morphology0.90363963
86MP0005379_endocrine/exocrine_gland_phen0.89760664
87MP0002152_abnormal_brain_morphology0.89660223
88MP0003861_abnormal_nervous_system0.89499633
89MP0000653_abnormal_sex_gland0.89343636
90MP0001293_anophthalmia0.89321819
91MP0001145_abnormal_male_reproductive0.88955799
92MP0002233_abnormal_nose_morphology0.88178387
93MP0003123_paternal_imprinting0.87227038
94MP0002751_abnormal_autonomic_nervous0.82153014
95MP0005389_reproductive_system_phenotype0.81870870
96MP0002229_neurodegeneration0.79933982
97MP0002876_abnormal_thyroid_physiology0.79609520
98MP0002733_abnormal_thermal_nociception0.78936655
99MP0001963_abnormal_hearing_physiology0.77596660
100MP0005195_abnormal_posterior_eye0.77547634

Predicted human phenotypes

RankGene SetZ-score
1Nephronophthisis (HP:0000090)3.65472201
2Type II lissencephaly (HP:0007260)3.38274817
3Molar tooth sign on MRI (HP:0002419)3.34415569
4Abnormality of midbrain morphology (HP:0002418)3.34415569
5Cerebellar dysplasia (HP:0007033)3.27722786
6Pancreatic cysts (HP:0001737)3.26023455
7True hermaphroditism (HP:0010459)3.24472239
8Pancreatic fibrosis (HP:0100732)3.19389509
9Medial flaring of the eyebrow (HP:0010747)3.11873052
10Gait imbalance (HP:0002141)3.11340115
11Abnormality of the renal medulla (HP:0100957)3.08086847
12Chronic hepatic failure (HP:0100626)3.05808374
13Oligodactyly (hands) (HP:0001180)2.96511141
14Volvulus (HP:0002580)2.96164573
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.95019993
16Congenital primary aphakia (HP:0007707)2.91743560
17Focal motor seizures (HP:0011153)2.88690806
18Abnormality of the renal cortex (HP:0011035)2.79371391
19Tubulointerstitial nephritis (HP:0001970)2.75480466
20Abnormal respiratory motile cilium physiology (HP:0012261)2.72319977
21Abnormal respiratory epithelium morphology (HP:0012253)2.72011954
22Abnormal respiratory motile cilium morphology (HP:0005938)2.72011954
23Abnormal ciliary motility (HP:0012262)2.71854553
24Hypothermia (HP:0002045)2.71377291
25Nephrogenic diabetes insipidus (HP:0009806)2.64803082
26Occipital encephalocele (HP:0002085)2.58136847
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.55904830
28Absent/shortened dynein arms (HP:0200106)2.55904830
29Hyperventilation (HP:0002883)2.52137911
30Rhinitis (HP:0012384)2.51731247
31Lissencephaly (HP:0001339)2.49706871
32Tubular atrophy (HP:0000092)2.46530407
33Genital tract atresia (HP:0001827)2.41414578
34Postaxial foot polydactyly (HP:0001830)2.38451874
35Vaginal atresia (HP:0000148)2.35848370
36Drooling (HP:0002307)2.32661261
37Limb dystonia (HP:0002451)2.30182181
38Cystic liver disease (HP:0006706)2.29551596
39Oligodactyly (HP:0012165)2.23903158
40Focal seizures (HP:0007359)2.16982407
41Postaxial hand polydactyly (HP:0001162)2.16197794
42Tubulointerstitial abnormality (HP:0001969)2.15128681
43Retinal dysplasia (HP:0007973)2.13260172
44Febrile seizures (HP:0002373)2.12035926
45Broad-based gait (HP:0002136)2.03719320
46Intestinal atresia (HP:0011100)2.03090625
47Abnormality of the corticospinal tract (HP:0002492)2.02740424
48Agitation (HP:0000713)2.01922677
49Proximal tubulopathy (HP:0000114)2.01598358
50Epileptic encephalopathy (HP:0200134)2.00685047
51Excessive salivation (HP:0003781)2.00493989
52Preaxial hand polydactyly (HP:0001177)1.97168944
53Myokymia (HP:0002411)1.96379709
54Hypsarrhythmia (HP:0002521)1.95092650
55Poor coordination (HP:0002370)1.94240414
56Epileptiform EEG discharges (HP:0011182)1.93388654
57EEG with generalized epileptiform discharges (HP:0011198)1.91471776
58Sclerocornea (HP:0000647)1.89489715
59Abnormal drinking behavior (HP:0030082)1.88778346
60Polydipsia (HP:0001959)1.88778346
61Optic nerve hypoplasia (HP:0000609)1.87643461
62Specific learning disability (HP:0001328)1.86445321
63Aplasia/Hypoplasia of the tibia (HP:0005772)1.85748604
64Pheochromocytoma (HP:0002666)1.85502219
65Absent speech (HP:0001344)1.84352037
66Degeneration of the lateral corticospinal tracts (HP:0002314)1.83768729
67Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83768729
68Dialeptic seizures (HP:0011146)1.82601267
69Congenital stationary night blindness (HP:0007642)1.81771458
70Male pseudohermaphroditism (HP:0000037)1.80289648
71Pachygyria (HP:0001302)1.80105302
72Aplasia/Hypoplasia of the tongue (HP:0010295)1.78604340
73Renal cortical cysts (HP:0000803)1.77995738
74Congenital hepatic fibrosis (HP:0002612)1.75336629
75Hypoplasia of the brainstem (HP:0002365)1.74353299
76Aplasia/Hypoplasia of the brainstem (HP:0007362)1.74353299
77Anencephaly (HP:0002323)1.73472695
78Aplasia/Hypoplasia of the lens (HP:0008063)1.73268412
79Short tibia (HP:0005736)1.72795632
80Labial hypoplasia (HP:0000066)1.71014533
81Generalized tonic-clonic seizures (HP:0002069)1.69459865
82Neuroendocrine neoplasm (HP:0100634)1.69318279
83Stage 5 chronic kidney disease (HP:0003774)1.69316516
84Hemiparesis (HP:0001269)1.68439237
85Polyphagia (HP:0002591)1.66117586
86Menstrual irregularities (HP:0000858)1.65822833
87Median cleft lip (HP:0000161)1.63319666
88Anophthalmia (HP:0000528)1.63191759
89Inability to walk (HP:0002540)1.62314364
90Atonic seizures (HP:0010819)1.60734451
91Prominent nasal bridge (HP:0000426)1.60011934
92Amblyopia (HP:0000646)1.58396470
93Multicystic kidney dysplasia (HP:0000003)1.58117772
94Tubulointerstitial fibrosis (HP:0005576)1.57639825
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.56331823
96Retinitis pigmentosa (HP:0000510)1.56271361
97Morphological abnormality of the pyramidal tract (HP:0002062)1.55415767
98Severe muscular hypotonia (HP:0006829)1.54649735
99Progressive cerebellar ataxia (HP:0002073)1.53363893
100Absence seizures (HP:0002121)1.52318373

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.92004242
2PNCK3.60829346
3MAP3K42.89744639
4FRK2.89048218
5MARK12.86694731
6MAP2K72.43071722
7MAPK152.09094058
8EPHA32.07076088
9STK38L2.04106779
10MAP4K22.02062754
11ACVR1B1.85075632
12ZAK1.83807290
13MAPK131.82364870
14PINK11.81769574
15WNK31.78083090
16BMPR1B1.76526442
17BCR1.75514856
18TRIM281.72757704
19EPHA41.67073211
20ERBB31.67072984
21NTRK31.63935604
22WNK41.56818572
23CSNK1G21.48151067
24ADRBK21.39989662
25MAP2K41.39762148
26GRK11.37390447
27CDK191.32380607
28CSNK1G31.30585247
29NTRK21.28381649
30CSNK1G11.24508292
31DYRK21.21607158
32CSNK1A1L1.21480192
33PLK21.21111644
34MUSK1.20600009
35PRKD31.18021088
36PHKG21.16431183
37PHKG11.16431183
38CAMK1G1.12355250
39EIF2AK31.09828343
40WEE11.07700385
41LATS11.07051717
42MINK11.03947287
43MET1.01738524
44STK391.01734666
45PRKCG1.00336627
46DAPK21.00123227
47OXSR10.99007930
48CAMKK20.96128300
49UHMK10.93236860
50BRSK20.93155763
51PAK30.90024301
52PRKCE0.87689639
53INSRR0.87340924
54TNIK0.85577604
55TSSK60.84464620
56FGFR20.81458068
57VRK10.76649685
58TLK10.73022777
59AKT30.69184261
60PAK60.65819466
61PTK2B0.65612132
62STK380.65466295
63CAMK2A0.65266753
64PLK30.60970239
65SGK2230.59258004
66SGK4940.59258004
67PRKAA10.59130868
68MST40.58770586
69SIK20.57113244
70PLK10.56175786
71DYRK1A0.54383065
72PKN10.54116579
73MAP2K60.50534651
74CCNB10.50143354
75CAMK10.50111244
76PLK40.49718544
77FER0.49691201
78BRD40.49664291
79STK30.49483537
80CDK50.49246807
81CAMKK10.47874469
82MAP3K20.47403440
83NEK10.46232277
84LIMK10.45833660
85ADRBK10.45588397
86TTK0.44245317
87CSNK1E0.43783294
88RET0.43142917
89DYRK30.42734683
90CDK30.42452086
91BRSK10.41972699
92LATS20.40951767
93SRPK10.40105586
94CAMK2B0.38065511
95MKNK20.37221850
96PRKCZ0.36529061
97ATM0.36303322
98CSNK1A10.35337450
99PRKCI0.35075467
100PDK20.34873453

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.05757709
2Nicotine addiction_Homo sapiens_hsa050333.05354319
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.34563930
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.28260033
5Butanoate metabolism_Homo sapiens_hsa006502.24641840
6Steroid biosynthesis_Homo sapiens_hsa001001.97007802
7Protein export_Homo sapiens_hsa030601.95808215
8Phototransduction_Homo sapiens_hsa047441.95057246
9GABAergic synapse_Homo sapiens_hsa047271.80276727
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74160617
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72843950
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68548352
13Insulin secretion_Homo sapiens_hsa049111.66810394
14Circadian rhythm_Homo sapiens_hsa047101.59815132
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57742097
16Taste transduction_Homo sapiens_hsa047421.53937466
17Glutamatergic synapse_Homo sapiens_hsa047241.47332143
18Circadian entrainment_Homo sapiens_hsa047131.47210571
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47077750
20Morphine addiction_Homo sapiens_hsa050321.46182494
21Selenocompound metabolism_Homo sapiens_hsa004501.44345575
22Synaptic vesicle cycle_Homo sapiens_hsa047211.43890217
23Propanoate metabolism_Homo sapiens_hsa006401.39822708
24Dopaminergic synapse_Homo sapiens_hsa047281.38610099
25Cocaine addiction_Homo sapiens_hsa050301.38291023
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29923851
27Basal transcription factors_Homo sapiens_hsa030221.19233886
28Peroxisome_Homo sapiens_hsa041461.15892189
29Amphetamine addiction_Homo sapiens_hsa050311.13418433
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13151808
31Tryptophan metabolism_Homo sapiens_hsa003801.11859658
32beta-Alanine metabolism_Homo sapiens_hsa004101.11565956
33Hedgehog signaling pathway_Homo sapiens_hsa043401.10221250
34Linoleic acid metabolism_Homo sapiens_hsa005911.09616016
35Nitrogen metabolism_Homo sapiens_hsa009101.07821238
36Serotonergic synapse_Homo sapiens_hsa047261.07670430
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07033184
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04060030
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04023372
40Oocyte meiosis_Homo sapiens_hsa041140.96299257
41Fatty acid elongation_Homo sapiens_hsa000620.95873270
42Regulation of autophagy_Homo sapiens_hsa041400.94586834
43Basal cell carcinoma_Homo sapiens_hsa052170.94321479
44Axon guidance_Homo sapiens_hsa043600.93438803
45Oxidative phosphorylation_Homo sapiens_hsa001900.92014116
46Cardiac muscle contraction_Homo sapiens_hsa042600.90866474
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89684887
48Alcoholism_Homo sapiens_hsa050340.88974491
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86582189
50Hippo signaling pathway_Homo sapiens_hsa043900.86129476
51Huntingtons disease_Homo sapiens_hsa050160.85369361
52Ether lipid metabolism_Homo sapiens_hsa005650.84330103
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82913823
54Fanconi anemia pathway_Homo sapiens_hsa034600.80210053
55Ovarian steroidogenesis_Homo sapiens_hsa049130.79582316
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79064040
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79055172
58ABC transporters_Homo sapiens_hsa020100.78308305
59Olfactory transduction_Homo sapiens_hsa047400.77855258
60Fatty acid metabolism_Homo sapiens_hsa012120.76592945
61Collecting duct acid secretion_Homo sapiens_hsa049660.74335106
62Salivary secretion_Homo sapiens_hsa049700.73646550
63Vitamin B6 metabolism_Homo sapiens_hsa007500.73018879
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72247785
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.70515564
66Parkinsons disease_Homo sapiens_hsa050120.70432311
67Long-term depression_Homo sapiens_hsa047300.70201102
68Phenylalanine metabolism_Homo sapiens_hsa003600.69584031
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.67981873
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66619758
71RNA degradation_Homo sapiens_hsa030180.66054021
72Cholinergic synapse_Homo sapiens_hsa047250.65943622
73Fatty acid biosynthesis_Homo sapiens_hsa000610.65737604
74Type II diabetes mellitus_Homo sapiens_hsa049300.65449011
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63852828
76Dorso-ventral axis formation_Homo sapiens_hsa043200.63474270
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62589955
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62545349
79cAMP signaling pathway_Homo sapiens_hsa040240.60926014
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.58928014
81Folate biosynthesis_Homo sapiens_hsa007900.58861417
82Calcium signaling pathway_Homo sapiens_hsa040200.58406989
83Chemical carcinogenesis_Homo sapiens_hsa052040.58219818
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57824474
85Sulfur metabolism_Homo sapiens_hsa009200.57782865
86Pyruvate metabolism_Homo sapiens_hsa006200.56436956
87Fatty acid degradation_Homo sapiens_hsa000710.56039603
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55508060
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54469931
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54264000
91Tyrosine metabolism_Homo sapiens_hsa003500.53970595
92Sphingolipid metabolism_Homo sapiens_hsa006000.53578028
93Bile secretion_Homo sapiens_hsa049760.53231220
94Arginine biosynthesis_Homo sapiens_hsa002200.51304143
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50840214
96Histidine metabolism_Homo sapiens_hsa003400.50357527
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50181009
98Retinol metabolism_Homo sapiens_hsa008300.49926745
99Metabolic pathways_Homo sapiens_hsa011000.49196596
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47241451

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