KIAA0408

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.83504014
2presynaptic membrane assembly (GO:0097105)4.87845560
3postsynaptic membrane organization (GO:0001941)4.79575732
4neuron cell-cell adhesion (GO:0007158)4.76336745
5cell migration in hindbrain (GO:0021535)4.71850571
6nucleobase catabolic process (GO:0046113)4.71699489
7presynaptic membrane organization (GO:0097090)4.63589938
8neuron recognition (GO:0008038)4.37702747
9axonal fasciculation (GO:0007413)4.30440962
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.30340554
11cerebral cortex radially oriented cell migration (GO:0021799)4.14138760
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.11093764
13neurotransmitter-gated ion channel clustering (GO:0072578)4.04234293
14behavioral response to nicotine (GO:0035095)3.97186992
15central nervous system projection neuron axonogenesis (GO:0021952)3.87138786
16dendrite morphogenesis (GO:0048813)3.82343218
17synaptic vesicle maturation (GO:0016188)3.73211065
18protein localization to synapse (GO:0035418)3.70603278
19vocalization behavior (GO:0071625)3.67994511
20glutamate receptor signaling pathway (GO:0007215)3.67257460
21synapse assembly (GO:0007416)3.66330564
22transmission of nerve impulse (GO:0019226)3.64304101
23dendritic spine morphogenesis (GO:0060997)3.60587842
24establishment of mitochondrion localization (GO:0051654)3.57704170
25regulation of short-term neuronal synaptic plasticity (GO:0048172)3.54315261
26synaptic transmission, glutamatergic (GO:0035249)3.51948541
27auditory behavior (GO:0031223)3.48735615
28gamma-aminobutyric acid transport (GO:0015812)3.48086860
29neuronal action potential propagation (GO:0019227)3.47621307
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.45597742
31regulation of telomere maintenance via telomerase (GO:0032210)3.42648096
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40801203
33regulation of synapse structural plasticity (GO:0051823)3.36759134
34positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.27974190
35positive regulation of synapse assembly (GO:0051965)3.26806043
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.26091312
37membrane depolarization during action potential (GO:0086010)3.26013445
38neuron-neuron synaptic transmission (GO:0007270)3.24905757
39positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.24880901
40negative regulation of telomere maintenance (GO:0032205)3.21543316
41layer formation in cerebral cortex (GO:0021819)3.20766480
42startle response (GO:0001964)3.20750416
43neurofilament cytoskeleton organization (GO:0060052)3.19152409
44central nervous system neuron axonogenesis (GO:0021955)3.18453542
45mitochondrion transport along microtubule (GO:0047497)3.16529969
46establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.16529969
47neuromuscular synaptic transmission (GO:0007274)3.12643786
48mechanosensory behavior (GO:0007638)3.10315247
49adult walking behavior (GO:0007628)3.08210909
50regulation of telomere maintenance (GO:0032204)3.07747724
51retinal ganglion cell axon guidance (GO:0031290)3.04944432
52neuronal action potential (GO:0019228)3.04063262
53exploration behavior (GO:0035640)3.00666038
54response to auditory stimulus (GO:0010996)2.97343579
55axon extension (GO:0048675)2.92886831
56synapse organization (GO:0050808)2.88214735
57positive regulation of synapse maturation (GO:0090129)2.87507036
58glutamate secretion (GO:0014047)2.85416502
59G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85359342
60locomotory exploration behavior (GO:0035641)2.84708603
61positive regulation of dendritic spine morphogenesis (GO:0061003)2.81579343
62regulation of synaptic transmission, glutamatergic (GO:0051966)2.80673281
63spinal cord development (GO:0021510)2.80014137
64regulation of synaptic vesicle exocytosis (GO:2000300)2.79853468
65cerebellar granule cell differentiation (GO:0021707)2.78780925
66negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.78605658
67cochlea development (GO:0090102)2.77631674
68dendrite development (GO:0016358)2.77027333
69regulation of glutamate receptor signaling pathway (GO:1900449)2.77015004
70hippocampus development (GO:0021766)2.75898745
71regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.75110561
72membrane depolarization (GO:0051899)2.74819982
73positive regulation of potassium ion transmembrane transport (GO:1901381)2.72556198
74regulation of synapse assembly (GO:0051963)2.72318057
75behavioral response to ethanol (GO:0048149)2.72175114
76regulation of synaptic vesicle transport (GO:1902803)2.70396760
77regulation of excitatory postsynaptic membrane potential (GO:0060079)2.70179148
78neurotransmitter secretion (GO:0007269)2.69991873
79calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.69865240
80regulation of postsynaptic membrane potential (GO:0060078)2.69771118
81protein polyglutamylation (GO:0018095)2.69077568
82neuronal ion channel clustering (GO:0045161)2.69024418
83neuron migration (GO:0001764)2.68982546
84artery development (GO:0060840)2.68763125
85negative regulation of cytosolic calcium ion concentration (GO:0051481)2.68666685
86limb bud formation (GO:0060174)2.67812711
87neuron projection extension (GO:1990138)2.67279158
88C4-dicarboxylate transport (GO:0015740)2.65516452
89behavioral defense response (GO:0002209)2.64742176
90behavioral fear response (GO:0001662)2.64742176
91regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.64395536
92heart field specification (GO:0003128)2.62014456
93secondary heart field specification (GO:0003139)2.62014456
94regulation of dendritic spine morphogenesis (GO:0061001)2.61122898
95adult behavior (GO:0030534)2.61122493
96ventricular trabecula myocardium morphogenesis (GO:0003222)2.60602728
97forebrain neuron differentiation (GO:0021879)2.60316832
98negative regulation of telomerase activity (GO:0051974)2.60157294
99negative regulation of axon extension (GO:0030517)2.59890861
100glycosphingolipid biosynthetic process (GO:0006688)2.59179342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.63222791
2GBX2_23144817_ChIP-Seq_PC3_Human3.52912226
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.22867419
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.93796773
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.84378003
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.69430252
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56701879
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.54136926
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.53827127
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43761037
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42685855
12REST_21632747_ChIP-Seq_MESCs_Mouse2.40876099
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.40176487
14TAF15_26573619_Chip-Seq_HEK293_Human2.32200219
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.28888048
16ZNF274_21170338_ChIP-Seq_K562_Hela2.14771671
17PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.10512706
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.07476181
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05945169
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04182871
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03767193
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99433876
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99316395
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98173169
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93790762
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92825111
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89458496
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89458496
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.89005512
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88727139
31IGF1R_20145208_ChIP-Seq_DFB_Human1.86291183
32RNF2_27304074_Chip-Seq_NSC_Mouse1.86082201
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.85647051
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82788870
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81186873
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78044559
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75863259
38FUS_26573619_Chip-Seq_HEK293_Human1.75392619
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.73331815
40P300_19829295_ChIP-Seq_ESCs_Human1.71680092
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70018975
42SMAD4_21799915_ChIP-Seq_A2780_Human1.69494177
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66043467
44AR_21572438_ChIP-Seq_LNCaP_Human1.64685039
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56828331
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55254669
47DROSHA_22980978_ChIP-Seq_HELA_Human1.54045704
48VDR_22108803_ChIP-Seq_LS180_Human1.52321634
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.50616119
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50550690
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50550690
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50360628
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.48888453
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47086646
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46140201
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42838521
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42117119
58STAT3_23295773_ChIP-Seq_U87_Human1.39659000
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39618062
60AR_25329375_ChIP-Seq_VCAP_Human1.37176912
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33448805
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33320868
63EWS_26573619_Chip-Seq_HEK293_Human1.31526100
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.27542208
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27303605
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26976737
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.26642665
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25895616
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25663797
70TCF4_23295773_ChIP-Seq_U87_Human1.24312764
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.24239250
72CBP_20019798_ChIP-Seq_JUKART_Human1.14456605
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14456605
74RUNX2_22187159_ChIP-Seq_PCA_Human1.13760592
75ER_23166858_ChIP-Seq_MCF-7_Human1.12064212
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11927995
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10874010
78LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09743793
79RARB_27405468_Chip-Seq_BRAIN_Mouse1.09100531
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08791903
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08315781
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07861445
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07545533
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07359587
85BCAT_22108803_ChIP-Seq_LS180_Human1.05410365
86STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05220740
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.03860592
88CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02683812
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02496306
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02157530
91SOX9_26525672_Chip-Seq_HEART_Mouse1.02027490
92AR_19668381_ChIP-Seq_PC3_Human1.01988406
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01875457
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.01841353
95RING1B_27294783_Chip-Seq_NPCs_Mouse1.01350999
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.01327587
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00648818
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00322063
99KDM2B_26808549_Chip-Seq_REH_Human0.98494933
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97667235

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.09385219
2MP0004270_analgesia3.70959459
3MP0004859_abnormal_synaptic_plasticity3.42515538
4MP0000778_abnormal_nervous_system2.88123978
5MP0003635_abnormal_synaptic_transmissio2.86103660
6MP0003787_abnormal_imprinting2.72333997
7MP0005423_abnormal_somatic_nervous2.67778825
8MP0009745_abnormal_behavioral_response2.47363165
9MP0002734_abnormal_mechanical_nocicepti2.39255629
10MP0002735_abnormal_chemical_nociception2.38837766
11MP0002822_catalepsy2.37846809
12MP0002063_abnormal_learning/memory/cond2.32994600
13MP0002272_abnormal_nervous_system2.26634822
14MP0006276_abnormal_autonomic_nervous2.23331480
15MP0002064_seizures2.21915847
16MP0001968_abnormal_touch/_nociception2.19063735
17MP0009046_muscle_twitch2.15096286
18MP0002572_abnormal_emotion/affect_behav2.05128552
19MP0003122_maternal_imprinting1.99573380
20MP0002638_abnormal_pupillary_reflex1.96070168
21MP0001486_abnormal_startle_reflex1.95590095
22MP0002736_abnormal_nociception_after1.92253580
23MP0002184_abnormal_innervation1.88928177
24MP0004133_heterotaxia1.81610689
25MP0004145_abnormal_muscle_electrophysio1.72822009
26MP0000955_abnormal_spinal_cord1.71046931
27MP0006292_abnormal_olfactory_placode1.69602880
28MP0004885_abnormal_endolymph1.69155398
29MP0002557_abnormal_social/conspecific_i1.67697657
30MP0005386_behavior/neurological_phenoty1.67365625
31MP0004924_abnormal_behavior1.67365625
32MP0003121_genomic_imprinting1.66766957
33MP0002733_abnormal_thermal_nociception1.66382925
34MP0001970_abnormal_pain_threshold1.65660086
35MP0001529_abnormal_vocalization1.64233052
36MP0002067_abnormal_sensory_capabilities1.59481314
37MP0008877_abnormal_DNA_methylation1.59233725
38MP0000631_abnormal_neuroendocrine_gland1.56717333
39MP0004811_abnormal_neuron_physiology1.55546315
40MP0002102_abnormal_ear_morphology1.53610971
41MP0002882_abnormal_neuron_morphology1.52843702
42MP0005551_abnormal_eye_electrophysiolog1.51778419
43MP0001440_abnormal_grooming_behavior1.48903580
44MP0004742_abnormal_vestibular_system1.47051960
45MP0001984_abnormal_olfaction1.46176354
46MP0000569_abnormal_digit_pigmentation1.44712496
47MP0005646_abnormal_pituitary_gland1.40142603
48MP0000566_synostosis1.38129877
49MP0004142_abnormal_muscle_tone1.35761418
50MP0001188_hyperpigmentation1.31731464
51MP0005394_taste/olfaction_phenotype1.30091596
52MP0005499_abnormal_olfactory_system1.30091596
53MP0003890_abnormal_embryonic-extraembry1.27121875
54MP0002752_abnormal_somatic_nervous1.24159316
55MP0002152_abnormal_brain_morphology1.23763570
56MP0008789_abnormal_olfactory_epithelium1.23758697
57MP0002751_abnormal_autonomic_nervous1.23647547
58MP0006072_abnormal_retinal_apoptosis1.20480278
59MP0002234_abnormal_pharynx_morphology1.18710992
60MP0001501_abnormal_sleep_pattern1.16586322
61MP0002066_abnormal_motor_capabilities/c1.15238616
62MP0005187_abnormal_penis_morphology1.14220973
63MP0002163_abnormal_gland_morphology1.13892837
64MP0001485_abnormal_pinna_reflex1.12829757
65MP0008569_lethality_at_weaning1.10460258
66MP0005645_abnormal_hypothalamus_physiol1.08223342
67MP0001905_abnormal_dopamine_level1.04912483
68MP0003861_abnormal_nervous_system1.04188083
69MP0002909_abnormal_adrenal_gland1.03641931
70MP0003938_abnormal_ear_development0.98432406
71MP0000026_abnormal_inner_ear0.95508043
72MP0001299_abnormal_eye_distance/0.95371975
73MP0005253_abnormal_eye_physiology0.95188566
74MP0001963_abnormal_hearing_physiology0.95028358
75MP0005195_abnormal_posterior_eye0.94780847
76MP0000049_abnormal_middle_ear0.93482255
77MP0001502_abnormal_circadian_rhythm0.90860719
78MP0003633_abnormal_nervous_system0.90311298
79MP0003879_abnormal_hair_cell0.88431066
80MP0002653_abnormal_ependyma_morphology0.86858791
81MP0002229_neurodegeneration0.86487938
82MP0003119_abnormal_digestive_system0.85090809
83MP0002069_abnormal_eating/drinking_beha0.84946296
84MP0002233_abnormal_nose_morphology0.83020592
85MP0001986_abnormal_taste_sensitivity0.82679864
86MP0003136_yellow_coat_color0.82368039
87MP0003646_muscle_fatigue0.80334225
88MP0003283_abnormal_digestive_organ0.80089959
89MP0003631_nervous_system_phenotype0.79479712
90MP0004130_abnormal_muscle_cell0.78919652
91MP0003123_paternal_imprinting0.78415749
92MP0004043_abnormal_pH_regulation0.72750694
93MP0010386_abnormal_urinary_bladder0.71495734
94MP0004085_abnormal_heartbeat0.71445781
95MP0003137_abnormal_impulse_conducting0.71166225
96MP0008872_abnormal_physiological_respon0.69892924
97MP0005379_endocrine/exocrine_gland_phen0.69650884
98MP0002081_perinatal_lethality0.69593885
99MP0003755_abnormal_palate_morphology0.67883459
100MP0001177_atelectasis0.66077305

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)5.28784700
2Focal motor seizures (HP:0011153)5.14250855
3Focal seizures (HP:0007359)4.61628562
4Atonic seizures (HP:0010819)4.37117165
5Myokymia (HP:0002411)4.26431328
6Febrile seizures (HP:0002373)3.90380084
7Broad-based gait (HP:0002136)3.82464166
8Epileptic encephalopathy (HP:0200134)3.66371978
9Drooling (HP:0002307)3.65131204
10Limb dystonia (HP:0002451)3.47069151
11Dialeptic seizures (HP:0011146)3.35382117
12Excessive salivation (HP:0003781)3.35107417
13Absence seizures (HP:0002121)3.17727685
14Nephronophthisis (HP:0000090)3.11244407
15Generalized tonic-clonic seizures (HP:0002069)3.10536633
16Progressive cerebellar ataxia (HP:0002073)3.00525283
17Absent speech (HP:0001344)2.99064648
18Gait imbalance (HP:0002141)2.83040133
19Polyphagia (HP:0002591)2.79759163
20Molar tooth sign on MRI (HP:0002419)2.77517230
21Abnormality of midbrain morphology (HP:0002418)2.77517230
22Abnormality of the aortic arch (HP:0012303)2.66595777
23Esophageal atresia (HP:0002032)2.66218054
24True hermaphroditism (HP:0010459)2.61640004
25Pancreatic fibrosis (HP:0100732)2.60428268
26Lissencephaly (HP:0001339)2.58863827
27Epileptiform EEG discharges (HP:0011182)2.55575722
28Pachygyria (HP:0001302)2.49117433
29Hepatoblastoma (HP:0002884)2.49094249
30Protruding tongue (HP:0010808)2.48913445
31EEG with generalized epileptiform discharges (HP:0011198)2.45791653
32Amblyopia (HP:0000646)2.45424143
33Abnormality of the labia minora (HP:0012880)2.45392042
34Action tremor (HP:0002345)2.42521023
35Hypsarrhythmia (HP:0002521)2.41530626
36Abnormality of the renal medulla (HP:0100957)2.40863501
37Status epilepticus (HP:0002133)2.39892623
38Hemiparesis (HP:0001269)2.38046710
39Abnormality of the corticospinal tract (HP:0002492)2.37982644
40Medial flaring of the eyebrow (HP:0010747)2.37674587
41Impaired vibration sensation in the lower limbs (HP:0002166)2.37157914
42Optic nerve hypoplasia (HP:0000609)2.34472722
43Pancreatic cysts (HP:0001737)2.34121446
44Agitation (HP:0000713)2.30433521
45Gastrointestinal atresia (HP:0002589)2.27958633
46Inability to walk (HP:0002540)2.27114628
47Exotropia (HP:0000577)2.18964909
48Fetal akinesia sequence (HP:0001989)2.13464562
49Congenital primary aphakia (HP:0007707)2.13363350
50Nephrogenic diabetes insipidus (HP:0009806)2.13309732
51Abnormal eating behavior (HP:0100738)2.12250842
52Genital tract atresia (HP:0001827)2.08884749
53Chronic hepatic failure (HP:0100626)2.07042462
54Vaginal atresia (HP:0000148)2.03675229
55Megalencephaly (HP:0001355)2.02191814
56Specific learning disability (HP:0001328)1.99431401
57Spastic tetraplegia (HP:0002510)1.99367391
58Poor eye contact (HP:0000817)1.99211119
59Intestinal atresia (HP:0011100)1.99198101
60Oligodactyly (hands) (HP:0001180)1.96941432
61Gaze-evoked nystagmus (HP:0000640)1.96545106
62Abnormality of salivation (HP:0100755)1.95987268
63Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95245965
64Urinary bladder sphincter dysfunction (HP:0002839)1.93738307
65Volvulus (HP:0002580)1.92871530
66Genetic anticipation (HP:0003743)1.90535790
67Narrow forehead (HP:0000341)1.88975182
68Intellectual disability, severe (HP:0010864)1.88560771
69Urinary urgency (HP:0000012)1.88036141
70Degeneration of the lateral corticospinal tracts (HP:0002314)1.87811723
71Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87811723
72Morphological abnormality of the pyramidal tract (HP:0002062)1.84345437
73Prolonged QT interval (HP:0001657)1.78610116
74Congenital stationary night blindness (HP:0007642)1.78507463
75Septo-optic dysplasia (HP:0100842)1.76597715
76Poor coordination (HP:0002370)1.75635971
77Sleep apnea (HP:0010535)1.75357519
78Impaired social interactions (HP:0000735)1.74944161
79Abnormal social behavior (HP:0012433)1.74944161
80Amyotrophic lateral sclerosis (HP:0007354)1.74854165
81Palpebral edema (HP:0100540)1.74330302
82Esotropia (HP:0000565)1.67696454
83Inappropriate behavior (HP:0000719)1.67602652
84Anencephaly (HP:0002323)1.66956639
85Calf muscle hypertrophy (HP:0008981)1.65249038
86Truncal ataxia (HP:0002078)1.64764637
87Hypoplasia of the corpus callosum (HP:0002079)1.64120600
88Hypoplasia of the brainstem (HP:0002365)1.63954001
89Aplasia/Hypoplasia of the brainstem (HP:0007362)1.63954001
90Cutaneous finger syndactyly (HP:0010554)1.63649754
91Tented upper lip vermilion (HP:0010804)1.63457911
92Shawl scrotum (HP:0000049)1.63445488
93Spastic gait (HP:0002064)1.62653556
94Rimmed vacuoles (HP:0003805)1.62072061
95Abnormality of the lower motor neuron (HP:0002366)1.61665324
96Cystic liver disease (HP:0006706)1.60579766
97Ulnar claw (HP:0001178)1.59561242
98Muscle hypertrophy of the lower extremities (HP:0008968)1.59178461
99Postaxial hand polydactyly (HP:0001162)1.57715666
100Type II lissencephaly (HP:0007260)1.55673096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.95006255
2CASK5.78828647
3TAOK23.22379027
4MAPK132.91600484
5SIK22.56489832
6MAP4K22.53271759
7MAP3K42.52853154
8TNIK2.40289111
9NTRK32.37166000
10WNK32.35801538
11NTRK22.17363204
12MAP2K72.02348874
13DYRK21.96274673
14EPHA41.88885726
15MAP2K61.85842630
16FRK1.83810556
17TLK11.74479910
18PHKG21.58535411
19PHKG11.58535411
20UHMK11.56249050
21PNCK1.55295407
22PINK11.54322174
23CDK191.53250945
24MINK11.41695719
25DAPK21.37774780
26CSNK1G21.31349114
27BCR1.23962717
28PRKCG1.23287967
29PAK31.15074640
30SGK21.13077064
31SGK2231.12136219
32SGK4941.12136219
33MAP2K41.06559782
34CDK51.05516030
35ADRBK21.04235226
36OBSCN1.03995974
37MAP3K50.99555388
38PAK60.98041067
39WNK40.94177854
40BMPR1B0.91415660
41EPHA30.90366282
42PKN10.89213909
43EPHB20.88607339
44DYRK1A0.83241017
45PLK20.82977826
46NTRK10.82560868
47CAMK2A0.79420743
48CSNK1G30.78861312
49OXSR10.76541650
50CAMKK20.73011098
51STK110.71684291
52CAMK2B0.71356290
53CSNK1G10.70998607
54KSR10.70705999
55CCNB10.70667169
56INSRR0.67793131
57CSNK1A1L0.65275804
58MKNK20.65186580
59PRKCZ0.63674207
60CAMKK10.63553085
61TYRO30.61482628
62CAMK40.61326172
63CAMK10.60290859
64SGK10.59730731
65PRKCE0.58769842
66SGK30.57178824
67PRKD30.55031222
68STK390.54365983
69CAMK1G0.53994004
70PIK3CA0.52906531
71AKT30.52289114
72PRKG10.52157854
73CDK150.50248049
74CDK180.50054224
75GRK10.49894794
76DYRK1B0.49233540
77MAP3K90.48675837
78ERBB30.48567742
79CDK11A0.48040817
80NME10.47714218
81CDK140.46600966
82TAOK10.44911474
83FGFR20.43715029
84PRKACA0.43028934
85CSNK1E0.40272639
86CSNK1D0.40159563
87CSNK1A10.39032453
88DYRK30.38587288
89RPS6KA30.36770242
90PRKAA10.35028187
91PRKCH0.34672692
92MAPK40.34130581
93CDK30.33494082
94PRKACB0.32352774
95MARK20.31801988
96MAPK120.30796824
97ADRBK10.30149680
98NUAK10.28772785
99MAPK80.28418386
100CAMK2G0.28271991

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.75631098
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68065579
3GABAergic synapse_Homo sapiens_hsa047272.61884491
4Circadian entrainment_Homo sapiens_hsa047132.54977054
5Glutamatergic synapse_Homo sapiens_hsa047242.51944516
6Phototransduction_Homo sapiens_hsa047442.50112185
7Morphine addiction_Homo sapiens_hsa050322.46720756
8Cocaine addiction_Homo sapiens_hsa050302.46237543
9Dopaminergic synapse_Homo sapiens_hsa047282.23430526
10Amphetamine addiction_Homo sapiens_hsa050312.17092777
11Insulin secretion_Homo sapiens_hsa049112.02899414
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90277764
13Cardiac muscle contraction_Homo sapiens_hsa042601.89009600
14Taste transduction_Homo sapiens_hsa047421.86755304
15Axon guidance_Homo sapiens_hsa043601.79274513
16Synaptic vesicle cycle_Homo sapiens_hsa047211.76610857
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73452678
18Cholinergic synapse_Homo sapiens_hsa047251.69064914
19Long-term depression_Homo sapiens_hsa047301.66917427
20Long-term potentiation_Homo sapiens_hsa047201.63747619
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49033040
22Salivary secretion_Homo sapiens_hsa049701.42024234
23Serotonergic synapse_Homo sapiens_hsa047261.41336939
24Oxytocin signaling pathway_Homo sapiens_hsa049211.40105709
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38156533
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34954230
27Olfactory transduction_Homo sapiens_hsa047401.33095554
28Gastric acid secretion_Homo sapiens_hsa049711.31478047
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26127633
30cAMP signaling pathway_Homo sapiens_hsa040241.24335600
31Butanoate metabolism_Homo sapiens_hsa006501.23875609
32Calcium signaling pathway_Homo sapiens_hsa040201.23374113
33Renin secretion_Homo sapiens_hsa049241.21433243
34Gap junction_Homo sapiens_hsa045401.09062265
35Dilated cardiomyopathy_Homo sapiens_hsa054141.07548153
36Dorso-ventral axis formation_Homo sapiens_hsa043201.07441433
37Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.05553393
38Parkinsons disease_Homo sapiens_hsa050121.03499541
39Oxidative phosphorylation_Homo sapiens_hsa001901.01982919
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00780172
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00682590
42Alzheimers disease_Homo sapiens_hsa050100.96763319
43Circadian rhythm_Homo sapiens_hsa047100.96720794
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95131599
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90876396
46Type II diabetes mellitus_Homo sapiens_hsa049300.88918875
47GnRH signaling pathway_Homo sapiens_hsa049120.88429006
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88075993
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85502858
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84877812
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84815014
52MAPK signaling pathway_Homo sapiens_hsa040100.82004298
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80959719
54Nitrogen metabolism_Homo sapiens_hsa009100.79854598
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.78507687
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.78438727
57ErbB signaling pathway_Homo sapiens_hsa040120.77535388
58Steroid biosynthesis_Homo sapiens_hsa001000.76722709
59Melanogenesis_Homo sapiens_hsa049160.75284558
60Estrogen signaling pathway_Homo sapiens_hsa049150.75204342
61Linoleic acid metabolism_Homo sapiens_hsa005910.73617403
62Hedgehog signaling pathway_Homo sapiens_hsa043400.73014541
63Alcoholism_Homo sapiens_hsa050340.72970859
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70818423
65Ras signaling pathway_Homo sapiens_hsa040140.69444424
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67404566
67Ether lipid metabolism_Homo sapiens_hsa005650.66550845
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65585395
69Rap1 signaling pathway_Homo sapiens_hsa040150.65490284
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63928518
71Basal cell carcinoma_Homo sapiens_hsa052170.63758017
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62549456
73Pancreatic secretion_Homo sapiens_hsa049720.60166971
74Oocyte meiosis_Homo sapiens_hsa041140.60129347
75Huntingtons disease_Homo sapiens_hsa050160.58718055
76Wnt signaling pathway_Homo sapiens_hsa043100.58610839
77Regulation of autophagy_Homo sapiens_hsa041400.57564947
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57509467
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56747851
80Hippo signaling pathway_Homo sapiens_hsa043900.56310799
81Glycerolipid metabolism_Homo sapiens_hsa005610.50296796
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50121203
83Glucagon signaling pathway_Homo sapiens_hsa049220.49083334
84Ovarian steroidogenesis_Homo sapiens_hsa049130.48006499
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47530597
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47101584
87Fatty acid biosynthesis_Homo sapiens_hsa000610.46355036
88Protein export_Homo sapiens_hsa030600.45141609
89Thyroid hormone synthesis_Homo sapiens_hsa049180.44575078
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.43686078
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42127598
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42011035
93beta-Alanine metabolism_Homo sapiens_hsa004100.40317303
94Propanoate metabolism_Homo sapiens_hsa006400.39671583
95Glioma_Homo sapiens_hsa052140.38036972
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37756765
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37618994
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37600469
99Basal transcription factors_Homo sapiens_hsa030220.35763568
100Bile secretion_Homo sapiens_hsa049760.35504485

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