KIAA0101

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)5.73523958
2CENP-A containing nucleosome assembly (GO:0034080)5.64477216
3DNA strand elongation involved in DNA replication (GO:0006271)5.20639715
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.15508564
5telomere maintenance via semi-conservative replication (GO:0032201)5.13511406
6DNA replication checkpoint (GO:0000076)4.99513830
7DNA strand elongation (GO:0022616)4.98332853
8histone exchange (GO:0043486)4.63249806
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.55803368
10ATP synthesis coupled proton transport (GO:0015986)4.55803368
11telomere maintenance via recombination (GO:0000722)4.44585059
12DNA replication-independent nucleosome organization (GO:0034724)4.39153761
13DNA replication-independent nucleosome assembly (GO:0006336)4.39153761
14ribosomal small subunit assembly (GO:0000028)4.38867433
15viral transcription (GO:0019083)4.35631771
16mitotic recombination (GO:0006312)4.31636718
17translational termination (GO:0006415)4.30362404
18kinetochore organization (GO:0051383)4.23834360
19establishment of protein localization to mitochondrial membrane (GO:0090151)4.19871747
20nucleotide-excision repair, DNA gap filling (GO:0006297)4.11847192
21maturation of SSU-rRNA (GO:0030490)4.08290694
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.97088852
23establishment of integrated proviral latency (GO:0075713)3.96984954
24proteasome assembly (GO:0043248)3.94197861
25cotranslational protein targeting to membrane (GO:0006613)3.93658505
26ribosomal small subunit biogenesis (GO:0042274)3.87233173
27protein targeting to ER (GO:0045047)3.87048006
28kinetochore assembly (GO:0051382)3.76195148
29protein localization to kinetochore (GO:0034501)3.73375236
30mitotic sister chromatid segregation (GO:0000070)3.71458196
31establishment of protein localization to endoplasmic reticulum (GO:0072599)3.70737081
32mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.70422061
33chaperone-mediated protein transport (GO:0072321)3.69619741
34telomere maintenance via telomere lengthening (GO:0010833)3.68649813
35DNA ligation (GO:0006266)3.68478466
36replication fork processing (GO:0031297)3.68453652
37ribosomal large subunit biogenesis (GO:0042273)3.64038466
38translational elongation (GO:0006414)3.62963157
39DNA replication-dependent nucleosome organization (GO:0034723)3.62652049
40DNA replication-dependent nucleosome assembly (GO:0006335)3.62652049
41protein localization to endoplasmic reticulum (GO:0070972)3.59747830
42DNA double-strand break processing (GO:0000729)3.57563880
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54391944
44exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53773290
45purine nucleobase biosynthetic process (GO:0009113)3.52536544
46DNA replication initiation (GO:0006270)3.50429369
47respiratory electron transport chain (GO:0022904)3.50377375
48negative regulation of DNA-dependent DNA replication (GO:2000104)3.47993079
49protein K6-linked ubiquitination (GO:0085020)3.46613870
50electron transport chain (GO:0022900)3.45273372
51DNA unwinding involved in DNA replication (GO:0006268)3.41388672
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.41209947
53mitotic metaphase plate congression (GO:0007080)3.41169791
54translational initiation (GO:0006413)3.40820072
55sister chromatid segregation (GO:0000819)3.40218191
56nucleobase biosynthetic process (GO:0046112)3.37412429
57cellular protein complex disassembly (GO:0043624)3.36439874
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.35363607
59mitochondrial respiratory chain complex assembly (GO:0033108)3.34812443
60regulation of centriole replication (GO:0046599)3.34020199
61spliceosomal snRNP assembly (GO:0000387)3.32020343
62protein complex biogenesis (GO:0070271)3.31842853
63DNA catabolic process, exonucleolytic (GO:0000738)3.31310917
64transcription-coupled nucleotide-excision repair (GO:0006283)3.30332136
65maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.27850653
66mitochondrial respiratory chain complex I assembly (GO:0032981)3.27494584
67NADH dehydrogenase complex assembly (GO:0010257)3.27494584
68mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.27494584
69regulation of mitochondrial translation (GO:0070129)3.26181747
70viral life cycle (GO:0019058)3.23687918
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22806261
72translation (GO:0006412)3.21944549
73chromatin assembly or disassembly (GO:0006333)3.21053828
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20268632
75regulation of mitotic spindle checkpoint (GO:1903504)3.17925224
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.17925224
77protein neddylation (GO:0045116)3.16796911
78metaphase plate congression (GO:0051310)3.16020258
79meiotic chromosome segregation (GO:0045132)3.14141813
80recombinational repair (GO:0000725)3.14130394
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14127771
82protein localization to chromosome, centromeric region (GO:0071459)3.12805996
83double-strand break repair via homologous recombination (GO:0000724)3.10792944
84mitotic chromosome condensation (GO:0007076)3.10020768
85somatic hypermutation of immunoglobulin genes (GO:0016446)3.09576232
86somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09576232
87negative regulation of ligase activity (GO:0051352)3.09017202
88negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.09017202
89rRNA modification (GO:0000154)3.08615179
90termination of RNA polymerase III transcription (GO:0006386)3.08420500
91transcription elongation from RNA polymerase III promoter (GO:0006385)3.08420500
92establishment of viral latency (GO:0019043)3.03730890
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01863651
94DNA strand renaturation (GO:0000733)3.00271529
95deoxyribonucleotide biosynthetic process (GO:0009263)2.99744789
96IMP biosynthetic process (GO:0006188)2.97984351
97regulation of DNA endoreduplication (GO:0032875)2.97186262
98pseudouridine synthesis (GO:0001522)2.96993188
99regulation of double-strand break repair via homologous recombination (GO:0010569)2.95286647
100regulation of nuclear cell cycle DNA replication (GO:0033262)2.95223222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.74687120
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.81066721
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.72205946
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.92726806
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.92590190
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.85071833
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.75199874
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.43454514
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.39881689
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.10068624
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.90063008
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89130309
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79953429
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.78042603
15ELK1_19687146_ChIP-ChIP_HELA_Human2.62373027
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.61511958
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54702148
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48314500
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45704306
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42854986
21* E2F1_21310950_ChIP-Seq_MCF-7_Human2.36797536
22AR_21909140_ChIP-Seq_LNCAP_Human2.35745923
23VDR_23849224_ChIP-Seq_CD4+_Human2.29760671
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.29055949
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.22805784
26FOXP3_21729870_ChIP-Seq_TREG_Human2.18379495
27TTF2_22483619_ChIP-Seq_HELA_Human2.05443702
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94774902
29XRN2_22483619_ChIP-Seq_HELA_Human1.92274549
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91838783
31DCP1A_22483619_ChIP-Seq_HELA_Human1.90712205
32MYC_18940864_ChIP-ChIP_HL60_Human1.89917691
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88762616
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87823555
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.77107595
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75375778
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74384147
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73582560
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72597142
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69625547
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64429295
42EWS_26573619_Chip-Seq_HEK293_Human1.62148169
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61299986
44* GABP_19822575_ChIP-Seq_HepG2_Human1.57577080
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.55071808
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53487634
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50386818
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47360872
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44934962
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44723762
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44090232
52ZNF274_21170338_ChIP-Seq_K562_Hela1.41029004
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37079087
54FUS_26573619_Chip-Seq_HEK293_Human1.33939518
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.30274689
56VDR_22108803_ChIP-Seq_LS180_Human1.27548622
57IRF1_19129219_ChIP-ChIP_H3396_Human1.23163892
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21915671
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21781849
60* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20957494
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.18384508
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16827485
63* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16715368
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.14409072
65* NANOG_16153702_ChIP-ChIP_HESCs_Human1.14210908
66KDM5A_27292631_Chip-Seq_BREAST_Human1.11403751
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11151318
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07747200
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01811385
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93515037
71ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93410256
72FLI1_27457419_Chip-Seq_LIVER_Mouse0.91759632
73ELK1_22589737_ChIP-Seq_MCF10A_Human0.90512341
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84734491
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84730233
76ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83934100
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82543747
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81960344
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79350051
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79020824
81NOTCH1_21737748_ChIP-Seq_TLL_Human0.77112422
82SOX17_20123909_ChIP-Seq_XEN_Mouse0.73489510
83ESR1_15608294_ChIP-ChIP_MCF-7_Human0.72725411
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.72517781
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.72293327
86IGF1R_20145208_ChIP-Seq_DFB_Human0.70848515
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.70752539
88RBPJ_22232070_ChIP-Seq_NCS_Mouse0.69842405
89POU3F2_20337985_ChIP-ChIP_501MEL_Human0.69137728
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.68716251
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.68173416
92TP53_22573176_ChIP-Seq_HFKS_Human0.67397612
93CTBP1_25329375_ChIP-Seq_LNCAP_Human0.65752499
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.63898578
95CTBP2_25329375_ChIP-Seq_LNCAP_Human0.59742262
96PCGF2_27294783_Chip-Seq_ESCs_Mouse0.59454362
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.58609842
98FOXA1_27270436_Chip-Seq_PROSTATE_Human0.58148178
99FOXA1_25329375_ChIP-Seq_VCAP_Human0.58148178
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.58087649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.13934979
2MP0008058_abnormal_DNA_repair4.02168974
3MP0003693_abnormal_embryo_hatching3.99896640
4MP0003111_abnormal_nucleus_morphology3.64640966
5MP0004957_abnormal_blastocyst_morpholog3.50506273
6MP0009379_abnormal_foot_pigmentation3.46089975
7MP0008057_abnormal_DNA_replication3.33191643
8MP0003077_abnormal_cell_cycle3.13926618
9MP0006292_abnormal_olfactory_placode2.92496492
10MP0008932_abnormal_embryonic_tissue2.57729303
11MP0002938_white_spotting2.49460453
12MP0003136_yellow_coat_color2.38360143
13MP0008007_abnormal_cellular_replicative2.32887813
14MP0003718_maternal_effect2.27921381
15MP0009697_abnormal_copulation2.27409630
16MP0003806_abnormal_nucleotide_metabolis2.11921065
17MP0001293_anophthalmia2.04977440
18MP0010030_abnormal_orbit_morphology2.01356805
19MP0003786_premature_aging1.90826280
20MP0006072_abnormal_retinal_apoptosis1.85653020
21MP0008877_abnormal_DNA_methylation1.83843409
22MP0000372_irregular_coat_pigmentation1.70120302
23MP0001529_abnormal_vocalization1.64392630
24MP0003890_abnormal_embryonic-extraembry1.54794713
25MP0003941_abnormal_skin_development1.45718528
26MP0003937_abnormal_limbs/digits/tail_de1.45034241
27MP0004147_increased_porphyrin_level1.42872005
28MP0002102_abnormal_ear_morphology1.41677729
29MP0003186_abnormal_redox_activity1.40294409
30MP0002210_abnormal_sex_determination1.36637815
31MP0002160_abnormal_reproductive_system1.34907053
32MP0000350_abnormal_cell_proliferation1.34802332
33MP0006035_abnormal_mitochondrial_morpho1.33702840
34MP0002234_abnormal_pharynx_morphology1.29760939
35MP0006036_abnormal_mitochondrial_physio1.25880970
36MP0001286_abnormal_eye_development1.23088372
37MP0001697_abnormal_embryo_size1.21064671
38MP0001929_abnormal_gametogenesis1.18489403
39MP0008995_early_reproductive_senescence1.13558640
40MP0008789_abnormal_olfactory_epithelium1.12577793
41MP0005084_abnormal_gallbladder_morpholo1.11895295
42MP0000049_abnormal_middle_ear1.10903606
43MP0001145_abnormal_male_reproductive1.10122971
44MP0003567_abnormal_fetal_cardiomyocyte1.09457981
45MP0003315_abnormal_perineum_morphology1.08832388
46MP0002736_abnormal_nociception_after1.08771452
47MP0002085_abnormal_embryonic_tissue1.06444104
48MP0005389_reproductive_system_phenotype1.06441535
49MP0000631_abnormal_neuroendocrine_gland1.06134047
50MP0000653_abnormal_sex_gland1.05708862
51MP0000566_synostosis1.04766416
52MP0001485_abnormal_pinna_reflex1.04124777
53MP0010307_abnormal_tumor_latency1.04080731
54MP0003119_abnormal_digestive_system1.03828137
55MP0005253_abnormal_eye_physiology1.03687582
56MP0002697_abnormal_eye_size1.01095180
57MP0001672_abnormal_embryogenesis/_devel0.98389944
58MP0005380_embryogenesis_phenotype0.98389944
59MP0003121_genomic_imprinting0.97001024
60MP0002111_abnormal_tail_morphology0.95322813
61MP0002095_abnormal_skin_pigmentation0.94400398
62MP0000313_abnormal_cell_death0.94222863
63MP0001730_embryonic_growth_arrest0.94201198
64MP0001346_abnormal_lacrimal_gland0.93687398
65MP0002638_abnormal_pupillary_reflex0.90415602
66MP0004133_heterotaxia0.90097027
67MP0002084_abnormal_developmental_patter0.89429464
68MP0002837_dystrophic_cardiac_calcinosis0.88745185
69MP0005408_hypopigmentation0.88567462
70MP0001119_abnormal_female_reproductive0.87877640
71MP0005391_vision/eye_phenotype0.87438252
72MP0003698_abnormal_male_reproductive0.84943540
73MP0002751_abnormal_autonomic_nervous0.84026846
74MP0002396_abnormal_hematopoietic_system0.82999031
75MP0005551_abnormal_eye_electrophysiolog0.82588503
76MP0008872_abnormal_physiological_respon0.82452952
77MP0002233_abnormal_nose_morphology0.82159840
78MP0002080_prenatal_lethality0.81643171
79MP0009672_abnormal_birth_weight0.80330263
80MP0001764_abnormal_homeostasis0.80051936
81MP0000358_abnormal_cell_content/0.79950508
82MP0003011_delayed_dark_adaptation0.78593821
83MP0001919_abnormal_reproductive_system0.78088632
84MP0003984_embryonic_growth_retardation0.77778523
85MP0004142_abnormal_muscle_tone0.77208927
86MP0002088_abnormal_embryonic_growth/wei0.76201006
87MP0000647_abnormal_sebaceous_gland0.76121177
88MP0003123_paternal_imprinting0.75154990
89MP0005171_absent_coat_pigmentation0.74880221
90MP0002653_abnormal_ependyma_morphology0.74843023
91MP0002019_abnormal_tumor_incidence0.72612219
92MP0003195_calcinosis0.72584397
93MP0005075_abnormal_melanosome_morpholog0.70852829
94MP0004197_abnormal_fetal_growth/weight/0.70312271
95MP0003938_abnormal_ear_development0.69607980
96MP0002282_abnormal_trachea_morphology0.68985018
97MP0003755_abnormal_palate_morphology0.67249417
98MP0005195_abnormal_posterior_eye0.65689882
99MP0008875_abnormal_xenobiotic_pharmacok0.64819080
100MP0000427_abnormal_hair_cycle0.64769232

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.11537030
2Chromsome breakage (HP:0040012)4.76352640
3Reticulocytopenia (HP:0001896)4.50128566
4Meckel diverticulum (HP:0002245)4.19434574
5Acute necrotizing encephalopathy (HP:0006965)4.17858573
6Aplasia/Hypoplasia of the uvula (HP:0010293)4.09706123
7Abnormality of the ileum (HP:0001549)4.00270891
8Abnormal mitochondria in muscle tissue (HP:0008316)3.75263525
9Acute encephalopathy (HP:0006846)3.74160265
10Abnormality of chromosome stability (HP:0003220)3.69902919
11Birth length less than 3rd percentile (HP:0003561)3.68273066
12Mitochondrial inheritance (HP:0001427)3.67977103
13Abnormality of the preputium (HP:0100587)3.62270105
14Abnormality of cells of the erythroid lineage (HP:0012130)3.59970920
15Abnormal number of erythroid precursors (HP:0012131)3.59018229
16Increased hepatocellular lipid droplets (HP:0006565)3.56435727
17Colon cancer (HP:0003003)3.43781051
18Increased CSF lactate (HP:0002490)3.40806950
19Progressive macrocephaly (HP:0004481)3.35171263
20Macrocytic anemia (HP:0001972)3.26395538
21Lipid accumulation in hepatocytes (HP:0006561)3.23852517
22Hepatocellular necrosis (HP:0001404)3.12883025
23Small intestinal stenosis (HP:0012848)3.05025346
24Duodenal stenosis (HP:0100867)3.05025346
25Hepatic necrosis (HP:0002605)2.86271525
26Triphalangeal thumb (HP:0001199)2.84933420
27Congenital, generalized hypertrichosis (HP:0004540)2.83667324
28Abnormality of the carotid arteries (HP:0005344)2.82411861
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.82312457
30Absent thumb (HP:0009777)2.80379070
31Cerebral edema (HP:0002181)2.79036827
32Abnormality of the labia minora (HP:0012880)2.76643813
33Pallor (HP:0000980)2.67704299
34Abnormality of the duodenum (HP:0002246)2.64784700
35Renal Fanconi syndrome (HP:0001994)2.63113451
36Clubbing of toes (HP:0100760)2.61449844
37Pancreatic cysts (HP:0001737)2.49865899
38Duplicated collecting system (HP:0000081)2.39920148
39Increased serum lactate (HP:0002151)2.37007777
40Sloping forehead (HP:0000340)2.35533125
41Pancreatic fibrosis (HP:0100732)2.33751409
42Myelodysplasia (HP:0002863)2.31284104
43Abnormality of the renal collecting system (HP:0004742)2.27225925
44Ectopic kidney (HP:0000086)2.26387246
453-Methylglutaconic aciduria (HP:0003535)2.21560879
46Lactic acidosis (HP:0003128)2.21527608
47Abnormal lung lobation (HP:0002101)2.21053734
48Abnormality of alanine metabolism (HP:0010916)2.19993888
49Hyperalaninemia (HP:0003348)2.19993888
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19993888
51True hermaphroditism (HP:0010459)2.17828340
52Hypoplasia of the pons (HP:0012110)2.16574578
53Patellar aplasia (HP:0006443)2.14806721
54Molar tooth sign on MRI (HP:0002419)2.14304517
55Abnormality of midbrain morphology (HP:0002418)2.14304517
56Absent radius (HP:0003974)2.14036197
57Pancytopenia (HP:0001876)2.13945041
58Exertional dyspnea (HP:0002875)2.12994314
59Leukodystrophy (HP:0002415)2.11654019
60Absent forearm bone (HP:0003953)2.10833894
61Aplasia involving forearm bones (HP:0009822)2.10833894
62Abnormality of the pons (HP:0007361)2.10005598
63Septo-optic dysplasia (HP:0100842)2.09820776
64Increased intramyocellular lipid droplets (HP:0012240)2.08888467
65Respiratory failure (HP:0002878)2.03853268
66Horseshoe kidney (HP:0000085)2.03128180
67Optic disc pallor (HP:0000543)2.02884291
68Aplasia/Hypoplasia of the patella (HP:0006498)2.02199355
69Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00574554
70Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99863603
71Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99863603
72Methylmalonic acidemia (HP:0002912)1.97055171
73Short thumb (HP:0009778)1.96327007
74Abnormal number of incisors (HP:0011064)1.93098545
75Megaloblastic anemia (HP:0001889)1.92068434
76Abnormality of methionine metabolism (HP:0010901)1.91521873
77Respiratory difficulties (HP:0002880)1.90375658
78Abnormality of serum amino acid levels (HP:0003112)1.89558667
79Hyperglycinemia (HP:0002154)1.88431346
80Exercise intolerance (HP:0003546)1.87507578
81Sclerocornea (HP:0000647)1.86870881
82Abnormality of DNA repair (HP:0003254)1.84287802
83Pendular nystagmus (HP:0012043)1.84239655
84Breast hypoplasia (HP:0003187)1.81478009
85Hypoplastic pelvis (HP:0008839)1.81091994
86Nephronophthisis (HP:0000090)1.80629318
87Methylmalonic aciduria (HP:0012120)1.77221910
88Abnormality of cochlea (HP:0000375)1.75674172
89Type I transferrin isoform profile (HP:0003642)1.75625173
90Duplication of thumb phalanx (HP:0009942)1.75558577
91Cleft eyelid (HP:0000625)1.75362830
92Lethargy (HP:0001254)1.74903033
93Tracheoesophageal fistula (HP:0002575)1.73838430
94Small hand (HP:0200055)1.72635401
95Absent septum pellucidum (HP:0001331)1.70436703
96Volvulus (HP:0002580)1.70113864
97Aplastic anemia (HP:0001915)1.68379843
98Abnormality of renal resorption (HP:0011038)1.67830310
99Microvesicular hepatic steatosis (HP:0001414)1.67060029
100Bone marrow hypocellularity (HP:0005528)1.65131014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.72464931
2VRK24.36255729
3BUB14.01963021
4ZAK3.70296168
5WEE13.10267359
6PLK42.94555917
7TTK2.72080273
8SRPK12.65436886
9VRK12.61570239
10NEK12.41357335
11BRSK22.24638080
12STK162.21005711
13PLK32.20913365
14PBK2.16491685
15TAF12.08007874
16NUAK11.94948384
17NME11.91632434
18MKNK11.91307278
19TLK11.85489942
20BMPR1B1.83816284
21EIF2AK11.82135690
22PLK11.80803171
23MKNK21.77475442
24MST41.61505490
25CHEK21.60256841
26EIF2AK31.49960073
27TRIM281.48182428
28WNK31.48006849
29ATR1.47253108
30NEK21.35778016
31TSSK61.32849032
32AURKB1.32820872
33BRSK11.28849385
34CCNB11.26137143
35NME21.24241374
36TNIK1.21148488
37PASK1.17391529
38ACVR1B1.10548350
39DYRK21.03769877
40PNCK1.02168920
41CDK80.98078095
42EIF2AK20.96915209
43CDK70.91018287
44WNK40.89752157
45MAP4K20.89348655
46ADRBK20.87108877
47DYRK30.86331447
48TGFBR10.83767607
49GRK10.80779112
50AURKA0.80603455
51INSRR0.76278738
52ATM0.75694386
53CHEK10.74873001
54BCKDK0.71380975
55FRK0.66907933
56CSNK2A10.66901040
57STK40.65516547
58CSNK1G10.60786453
59CSNK2A20.60458475
60CSNK1G30.60433345
61PLK20.59702497
62RPS6KA50.57104067
63RPS6KA40.56147822
64RPS6KB20.53630052
65STK38L0.53492582
66STK30.50790232
67MAPKAPK50.50771942
68MELK0.50584812
69CDK10.50184975
70CSNK1G20.49842151
71CDK30.48465828
72OXSR10.46887266
73PDK20.46548655
74CDK20.42687638
75STK390.42618664
76CSNK1A1L0.39372488
77BCR0.38935882
78CSNK1E0.37404445
79CDK190.34973127
80CDK40.34845547
81PRKCG0.31034160
82PRKDC0.30985316
83ALK0.29865940
84MAP3K40.29490200
85MARK30.29347971
86ERBB30.27657454
87ADRBK10.26925205
88MAP3K80.24476217
89CSNK1A10.23325886
90PRKCI0.23291910
91MUSK0.23036683
92DAPK10.22313996
93CDK11A0.19920837
94CDK180.19680619
95MAP2K70.19579804
96MAPK130.19356960
97FGFR10.18521691
98CDK150.18499392
99EPHB20.17648238
100FLT30.17426991

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.56632865
2Mismatch repair_Homo sapiens_hsa034304.20820122
3Ribosome_Homo sapiens_hsa030104.09415077
4Homologous recombination_Homo sapiens_hsa034403.63715376
5Proteasome_Homo sapiens_hsa030503.43724031
6Oxidative phosphorylation_Homo sapiens_hsa001903.17123622
7Fanconi anemia pathway_Homo sapiens_hsa034602.86224961
8Parkinsons disease_Homo sapiens_hsa050122.80176297
9RNA polymerase_Homo sapiens_hsa030202.73098184
10Nucleotide excision repair_Homo sapiens_hsa034202.62290099
11Base excision repair_Homo sapiens_hsa034102.55702294
12Protein export_Homo sapiens_hsa030602.51167906
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39465800
14One carbon pool by folate_Homo sapiens_hsa006702.33089515
15Spliceosome_Homo sapiens_hsa030402.26839085
16Non-homologous end-joining_Homo sapiens_hsa034502.22010131
17Huntingtons disease_Homo sapiens_hsa050162.09842396
18Pyrimidine metabolism_Homo sapiens_hsa002401.95788669
19Cell cycle_Homo sapiens_hsa041101.88576930
20RNA transport_Homo sapiens_hsa030131.84736892
21Alzheimers disease_Homo sapiens_hsa050101.78310722
22RNA degradation_Homo sapiens_hsa030181.73523865
23Basal transcription factors_Homo sapiens_hsa030221.61926980
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51640859
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44617886
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38060071
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37127024
28Purine metabolism_Homo sapiens_hsa002301.34663330
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17490162
30Folate biosynthesis_Homo sapiens_hsa007901.16311481
31Cardiac muscle contraction_Homo sapiens_hsa042601.13571869
32Propanoate metabolism_Homo sapiens_hsa006401.12871297
33Pyruvate metabolism_Homo sapiens_hsa006201.11885695
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.10973740
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05999138
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04574735
37Selenocompound metabolism_Homo sapiens_hsa004500.96072111
38Glutathione metabolism_Homo sapiens_hsa004800.90400639
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86000457
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82174517
41p53 signaling pathway_Homo sapiens_hsa041150.82054649
42Sulfur relay system_Homo sapiens_hsa041220.81029122
43Fatty acid elongation_Homo sapiens_hsa000620.78692199
44mRNA surveillance pathway_Homo sapiens_hsa030150.77032118
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73247140
46Butanoate metabolism_Homo sapiens_hsa006500.71697930
47Steroid biosynthesis_Homo sapiens_hsa001000.70919607
48Vitamin B6 metabolism_Homo sapiens_hsa007500.70826845
49Oocyte meiosis_Homo sapiens_hsa041140.68422800
50Metabolic pathways_Homo sapiens_hsa011000.68017966
51Phototransduction_Homo sapiens_hsa047440.66709050
52Systemic lupus erythematosus_Homo sapiens_hsa053220.65368485
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63757193
54Basal cell carcinoma_Homo sapiens_hsa052170.61503323
55Nitrogen metabolism_Homo sapiens_hsa009100.60080942
56Biosynthesis of amino acids_Homo sapiens_hsa012300.57056262
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56458050
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53403727
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52128244
60Carbon metabolism_Homo sapiens_hsa012000.51683915
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51070239
62Tryptophan metabolism_Homo sapiens_hsa003800.47688361
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.46873516
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45105331
65Vitamin digestion and absorption_Homo sapiens_hsa049770.44898572
66Hedgehog signaling pathway_Homo sapiens_hsa043400.43831115
67Peroxisome_Homo sapiens_hsa041460.43278761
68Alcoholism_Homo sapiens_hsa050340.37318954
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36650435
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36296832
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33930047
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.33772388
73Linoleic acid metabolism_Homo sapiens_hsa005910.33697555
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32830253
75Caffeine metabolism_Homo sapiens_hsa002320.32565041
76N-Glycan biosynthesis_Homo sapiens_hsa005100.32475422
77Chemical carcinogenesis_Homo sapiens_hsa052040.30832304
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29310851
79Epstein-Barr virus infection_Homo sapiens_hsa051690.27406304
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26801336
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26303407
82beta-Alanine metabolism_Homo sapiens_hsa004100.25729301
83Retinol metabolism_Homo sapiens_hsa008300.24058624
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23709447
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23251895
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22402915
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20422359
88Fatty acid metabolism_Homo sapiens_hsa012120.20374902
89Fatty acid degradation_Homo sapiens_hsa000710.19768691
90Olfactory transduction_Homo sapiens_hsa047400.19592436
91TGF-beta signaling pathway_Homo sapiens_hsa043500.17392393
92Sulfur metabolism_Homo sapiens_hsa009200.17217267
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.16736179
94Arginine and proline metabolism_Homo sapiens_hsa003300.15575091
95Ether lipid metabolism_Homo sapiens_hsa005650.14909490
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14249498
97Hippo signaling pathway_Homo sapiens_hsa043900.13968684
98Lysine degradation_Homo sapiens_hsa003100.13475962
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12949886
100Wnt signaling pathway_Homo sapiens_hsa043100.11856456

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