KIAA0100

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was initially characterized in human as having high expression levels in breast carcinomas and breast cancer cell lines. This gene also has increased expression in prostrate cancer cells relative to normal prostrate tissues. Expression of this gene is negatively regulated by direct binding of the microRNA miR-195 to its 3' UTR. miR-195 has been shown to modulate the invasiveness of prostrate cancer cells and xenograft metastases by downgrading expression of this gene. In mouse, the protein encoded by this gene was identified as an antigen on acute monocytic leukemia cells. In human, alternative splicing results in multiple transcript variants encoding distinct isoforms; some of these isoforms are predicted to contain an RNA pol II promoter FMP27 protein domain and a Golgi-body-localization APT1 domain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.32220204
2Golgi transport vesicle coating (GO:0048200)5.32220204
3nuclear pore complex assembly (GO:0051292)5.10489933
4nuclear pore organization (GO:0006999)4.14330204
5protein localization to endosome (GO:0036010)4.10695649
6cytoskeletal anchoring at plasma membrane (GO:0007016)3.96454544
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.77459492
8pore complex assembly (GO:0046931)3.74533571
9cell-substrate junction assembly (GO:0007044)3.61033148
10adherens junction assembly (GO:0034333)3.60954174
11focal adhesion assembly (GO:0048041)3.56739045
12cell-substrate adherens junction assembly (GO:0007045)3.56739045
13regulation of histone H3-K27 methylation (GO:0061085)3.52949955
14hemidesmosome assembly (GO:0031581)3.47725161
15DNA unwinding involved in DNA replication (GO:0006268)3.38222357
16epithelial cell differentiation involved in prostate gland development (GO:0060742)3.37541030
17mitotic chromosome condensation (GO:0007076)3.32568609
18regulation of RNA export from nucleus (GO:0046831)3.30888358
19activation of Rac GTPase activity (GO:0032863)3.25542774
20regulation of nucleobase-containing compound transport (GO:0032239)3.25090930
21pinocytosis (GO:0006907)3.21764627
22negative regulation of erythrocyte differentiation (GO:0045647)3.21069358
23embryonic process involved in female pregnancy (GO:0060136)3.20071451
24positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.20043419
25regulation of translational fidelity (GO:0006450)3.19837950
26negative regulation of cell size (GO:0045792)3.19750189
27regulation of glucose import in response to insulin stimulus (GO:2001273)3.19747607
28insulin-like growth factor receptor signaling pathway (GO:0048009)3.14120575
29mannose metabolic process (GO:0006013)3.11009516
30protein retention in ER lumen (GO:0006621)3.06892466
31maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.06690854
32negative regulation of fatty acid transport (GO:2000192)3.05769545
33regulation of early endosome to late endosome transport (GO:2000641)3.04963451
34desmosome organization (GO:0002934)3.04824872
35epithelial cell-cell adhesion (GO:0090136)2.99356317
36vesicle coating (GO:0006901)2.98831929
37regulation of mammary gland epithelial cell proliferation (GO:0033599)2.98607748
38proline biosynthetic process (GO:0006561)2.95626190
39regulation of NFAT protein import into nucleus (GO:0051532)2.93996864
40spliceosomal tri-snRNP complex assembly (GO:0000244)2.93975010
41maternal placenta development (GO:0001893)2.88398718
42peptidyl-lysine dimethylation (GO:0018027)2.84987844
43protein export from nucleus (GO:0006611)2.80417690
44positive regulation of keratinocyte differentiation (GO:0045618)2.79792404
45barbed-end actin filament capping (GO:0051016)2.78255395
46COPII vesicle coating (GO:0048208)2.77017486
47cellular response to epidermal growth factor stimulus (GO:0071364)2.76637831
48iron ion import (GO:0097286)2.75324224
49basement membrane organization (GO:0071711)2.71375993
50histone H3-K36 demethylation (GO:0070544)2.70907268
51response to laminar fluid shear stress (GO:0034616)2.69567262
52branching involved in mammary gland duct morphogenesis (GO:0060444)2.69082531
53semaphorin-plexin signaling pathway (GO:0071526)2.68919278
54pentose-phosphate shunt (GO:0006098)2.68508170
55dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.68014068
56activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.67104289
57cortical actin cytoskeleton organization (GO:0030866)2.66961775
58positive regulation of Cdc42 GTPase activity (GO:0043089)2.65600482
59skin morphogenesis (GO:0043589)2.64875191
60glucocorticoid receptor signaling pathway (GO:0042921)2.64510091
61membrane protein ectodomain proteolysis (GO:0006509)2.64064528
62stress fiber assembly (GO:0043149)2.59770879
63apoptotic process involved in morphogenesis (GO:0060561)2.59339751
64positive regulation of nuclease activity (GO:0032075)2.57416929
65response to epidermal growth factor (GO:0070849)2.57125230
66apoptotic cell clearance (GO:0043277)2.56647428
67cell adhesion mediated by integrin (GO:0033627)2.56473242
68positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.53481495
69mRNA stabilization (GO:0048255)2.51257045
70RNA stabilization (GO:0043489)2.51257045
71protein localization to microtubule (GO:0035372)2.49049699
72hypotonic response (GO:0006971)2.48293075
73urea cycle (GO:0000050)2.46312434
74endoplasmic reticulum unfolded protein response (GO:0030968)2.44334082
75mammary gland epithelial cell proliferation (GO:0033598)2.43452904
76ER-nucleus signaling pathway (GO:0006984)2.43382473
77corticosteroid receptor signaling pathway (GO:0031958)2.40995197
78peptidyl-threonine modification (GO:0018210)2.40240718
79cellular protein complex localization (GO:0034629)2.40075607
80positive regulation of blood vessel endothelial cell migration (GO:0043536)2.39447550
81planar cell polarity pathway involved in neural tube closure (GO:0090179)2.36366809
82embryonic eye morphogenesis (GO:0048048)2.35161716
83glucose catabolic process (GO:0006007)2.34344548
84negative regulation of DNA repair (GO:0045738)2.33130163
85regulation of nuclease activity (GO:0032069)2.30424213
86DNA duplex unwinding (GO:0032508)2.29289085
87cortical cytoskeleton organization (GO:0030865)2.28741273
88NADPH regeneration (GO:0006740)2.27504729
89regulation of ARF protein signal transduction (GO:0032012)2.26488516
90dosage compensation (GO:0007549)2.26052449
91positive regulation of receptor recycling (GO:0001921)2.25766944
92glucose 6-phosphate metabolic process (GO:0051156)2.25390632
93mitotic sister chromatid cohesion (GO:0007064)2.23066884
94peptidyl-threonine phosphorylation (GO:0018107)2.22698762
95regulation of fatty acid beta-oxidation (GO:0031998)2.22580872
96surfactant homeostasis (GO:0043129)2.22261316
97protein complex localization (GO:0031503)2.22120916
98cellular response to unfolded protein (GO:0034620)2.21884881
993-UTR-mediated mRNA stabilization (GO:0070935)2.21642760
100regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.21285384

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.18625301
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.96444260
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.72919228
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.95989049
5MYC_22102868_ChIP-Seq_BL_Human2.82760420
6ZNF263_19887448_ChIP-Seq_K562_Human2.51981740
7VDR_21846776_ChIP-Seq_THP-1_Human2.37256620
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.30356491
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.23278327
10CLOCK_20551151_ChIP-Seq_293T_Human2.21317513
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.20212434
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.19884954
13RACK7_27058665_Chip-Seq_MCF-7_Human2.11735619
14KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.07009791
15TCF7_22412390_ChIP-Seq_EML_Mouse2.05780801
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.03457030
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.01865430
18LXR_22292898_ChIP-Seq_THP-1_Human1.95890199
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95560317
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.81572397
21* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.76854683
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75716858
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73148380
24AR_21909140_ChIP-Seq_LNCAP_Human1.71571379
25P300_27058665_Chip-Seq_ZR-75-30cells_Human1.70656120
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.69398208
27* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.67528844
28KDM2B_26808549_Chip-Seq_DND41_Human1.66569327
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61919728
30CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.59425643
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.58309059
32SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.57840938
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52247577
34KDM2B_26808549_Chip-Seq_K562_Human1.52147777
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49486160
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46759694
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46320458
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45826747
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45006417
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41691475
41TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.41100230
42CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.40575491
43KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39272127
44ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37897468
45RUNX1_27514584_Chip-Seq_MCF-7_Human1.37490800
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37477390
47ATF3_27146783_Chip-Seq_COLON_Human1.35804688
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35218637
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34396988
50VDR_24763502_ChIP-Seq_THP-1_Human1.34139868
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33868786
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33759577
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33731846
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31902753
55DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30308247
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28888865
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28172396
58* KDM2B_26808549_Chip-Seq_JURKAT_Human1.27041220
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24992006
60UBF1/2_26484160_Chip-Seq_HMECs_Human1.24824767
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24568193
62SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24061178
63SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24061178
64CHD1_26751641_Chip-Seq_LNCaP_Human1.22633828
65NCOR1_26117541_ChIP-Seq_K562_Human1.22247334
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21999742
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.20595181
68SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20200887
69MAF_26560356_Chip-Seq_TH1_Human1.20104441
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19660175
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19124089
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15819045
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15647371
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15380724
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.14173185
76NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13347566
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11269017
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10222606
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09948779
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09913654
81EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09827179
82TBX20_22328084_ChIP-Seq_HEART_Mouse1.09192847
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.09192847
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07410486
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06656131
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05900943
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05485998
88CREB1_26743006_Chip-Seq_LNCaP_Human1.05267780
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05190904
90TFEB_21752829_ChIP-Seq_HELA_Human1.03400716
91* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02625981
92ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01832700
93SMC4_20622854_ChIP-Seq_HELA_Human1.00691770
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00212434
95SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00149312
96* TP53_22127205_ChIP-Seq_IMR90_Human0.98734659
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.98399232
98MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97961045
99GATA6_25053715_ChIP-Seq_YYC3_Human0.97076360
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95720118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.67802147
2MP0010234_abnormal_vibrissa_follicle3.67106931
3MP0002877_abnormal_melanocyte_morpholog3.30209123
4MP0003566_abnormal_cell_adhesion3.01757743
5MP0005451_abnormal_body_composition2.93492205
6MP0005076_abnormal_cell_differentiation2.68387102
7MP0010352_gastrointestinal_tract_polyps2.66867748
8MP0008438_abnormal_cutaneous_collagen2.34349594
9MP0004185_abnormal_adipocyte_glucose2.33775152
10MP0004233_abnormal_muscle_weight2.29477970
11MP0005409_darkened_coat_color2.21652576
12MP0001849_ear_inflammation2.14545230
13MP0003091_abnormal_cell_migration2.11526640
14MP0005058_abnormal_lysosome_morphology2.09320332
15MP0004264_abnormal_extraembryonic_tissu2.04543856
16MP0002009_preneoplasia2.02884608
17MP0003300_gastrointestinal_ulcer1.93634184
18MP0002796_impaired_skin_barrier1.84504108
19MP0003191_abnormal_cellular_cholesterol1.79204791
20MP0003453_abnormal_keratinocyte_physiol1.72844854
21MP0000537_abnormal_urethra_morphology1.70797582
22MP0004272_abnormal_basement_membrane1.58269182
23MP0004858_abnormal_nervous_system1.57298253
24MP0005257_abnormal_intraocular_pressure1.56508326
25MP0008260_abnormal_autophagy1.56273647
26MP0002060_abnormal_skin_morphology1.46901923
27MP0002396_abnormal_hematopoietic_system1.43548902
28MP0002166_altered_tumor_susceptibility1.42520382
29MP0004808_abnormal_hematopoietic_stem1.41731528
30MP0000733_abnormal_muscle_development1.39288722
31MP0005666_abnormal_adipose_tissue1.36727551
32MP0005501_abnormal_skin_physiology1.34646646
33MP0001730_embryonic_growth_arrest1.33374156
34MP0004947_skin_inflammation1.31548389
35MP0008057_abnormal_DNA_replication1.28753745
36MP0009840_abnormal_foam_cell1.27444449
37MP0000003_abnormal_adipose_tissue1.23068869
38MP0005623_abnormal_meninges_morphology1.19118470
39MP0005621_abnormal_cell_physiology1.19031976
40MP0001348_abnormal_lacrimal_gland1.17380948
41MP0005375_adipose_tissue_phenotype1.15718697
42MP0001958_emphysema1.13203759
43MP0010307_abnormal_tumor_latency1.12766677
44MP0003111_abnormal_nucleus_morphology1.12698147
45MP0003172_abnormal_lysosome_physiology1.12281922
46MP0000858_altered_metastatic_potential1.11665725
47MP0002086_abnormal_extraembryonic_tissu1.11418325
48MP0005023_abnormal_wound_healing1.10794282
49MP0003984_embryonic_growth_retardation1.10613076
50MP0001661_extended_life_span1.10482455
51MP0002896_abnormal_bone_mineralization1.09087557
52MP0001915_intracranial_hemorrhage1.09083561
53MP0001216_abnormal_epidermal_layer1.08803297
54MP0005275_abnormal_skin_tensile1.07466481
55MP0002088_abnormal_embryonic_growth/wei1.05137684
56MP0009672_abnormal_birth_weight1.03935822
57MP0000350_abnormal_cell_proliferation1.03130994
58MP0005380_embryogenesis_phenotype1.02516981
59MP0001672_abnormal_embryogenesis/_devel1.02516981
60MP0000747_muscle_weakness1.01292947
61MP0004782_abnormal_surfactant_physiolog1.01022887
62MP0000627_abnormal_mammary_gland1.00878581
63MP0010630_abnormal_cardiac_muscle1.00422817
64MP0000751_myopathy1.00421218
65MP0003941_abnormal_skin_development0.98045168
66MP0000377_abnormal_hair_follicle0.97478744
67MP0002080_prenatal_lethality0.96100164
68MP0004087_abnormal_muscle_fiber0.95536467
69MP0010678_abnormal_skin_adnexa0.94963930
70MP0004957_abnormal_blastocyst_morpholog0.94792281
71MP0003279_aneurysm0.92444688
72MP0002098_abnormal_vibrissa_morphology0.91635854
73MP0002006_tumorigenesis0.91431403
74MP0000759_abnormal_skeletal_muscle0.89865270
75MP0003077_abnormal_cell_cycle0.89373420
76MP0003329_amyloid_beta_deposits0.89049901
77MP0000579_abnormal_nail_morphology0.87870030
78MP0000767_abnormal_smooth_muscle0.86815491
79MP0001873_stomach_inflammation0.86358000
80MP0003828_pulmonary_edema0.84939061
81MP0005083_abnormal_biliary_tract0.84112736
82MP0003763_abnormal_thymus_physiology0.84070406
83MP0009278_abnormal_bone_marrow0.83524309
84MP0005384_cellular_phenotype0.79706946
85MP0009931_abnormal_skin_appearance0.79014547
86MP0000467_abnormal_esophagus_morphology0.78593909
87MP0002269_muscular_atrophy0.77933356
88MP0003115_abnormal_respiratory_system0.77746300
89MP0006138_congestive_heart_failure0.76909696
90MP0000678_abnormal_parathyroid_gland0.75168567
91MP0000490_abnormal_crypts_of0.75081556
92MP0003221_abnormal_cardiomyocyte_apopto0.74887091
93MP0002089_abnormal_postnatal_growth/wei0.74137726
94MP0002998_abnormal_bone_remodeling0.72902627
95MP0001697_abnormal_embryo_size0.70326721
96MP0008007_abnormal_cellular_replicative0.69025073
97MP0005408_hypopigmentation0.68558165
98MP0009780_abnormal_chondrocyte_physiolo0.68448876
99MP0001881_abnormal_mammary_gland0.65488200
100MP0004381_abnormal_hair_follicle0.65368236

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.60917772
2Flat acetabular roof (HP:0003180)3.23940656
3Broad face (HP:0000283)2.99798941
4Protrusio acetabuli (HP:0003179)2.89820723
5Osteolytic defects of the phalanges of the hand (HP:0009771)2.83197108
6Osteolytic defects of the hand bones (HP:0009699)2.83197108
7Premature rupture of membranes (HP:0001788)2.82449902
8Distal lower limb amyotrophy (HP:0008944)2.69231618
9Asymmetry of the thorax (HP:0001555)2.68332860
10Increased connective tissue (HP:0009025)2.66313313
11Ankyloglossia (HP:0010296)2.56271419
12Cerebral aneurysm (HP:0004944)2.54283447
13Short nail (HP:0001799)2.51128862
14Vertebral compression fractures (HP:0002953)2.49859319
15Dysmetric saccades (HP:0000641)2.42342881
16Abnormality of the distal phalanx of the thumb (HP:0009617)2.39931387
17Abnormality of oral frenula (HP:0000190)2.38836199
18Termporal pattern (HP:0011008)2.38094137
19Insidious onset (HP:0003587)2.38094137
20Ulnar bowing (HP:0003031)2.34926858
21Thin bony cortex (HP:0002753)2.32130804
22Sparse lateral eyebrow (HP:0005338)2.31350186
23Centrally nucleated skeletal muscle fibers (HP:0003687)2.28501927
24Abnormality of the distal phalanges of the toes (HP:0010182)2.22108739
25Cervical subluxation (HP:0003308)2.22072849
26Advanced eruption of teeth (HP:0006288)2.16459773
27Disproportionate tall stature (HP:0001519)2.12658597
28Achilles tendon contracture (HP:0001771)2.11721546
29Insomnia (HP:0100785)2.11114318
30Syringomyelia (HP:0003396)2.08467737
31Spinal cord lesions (HP:0100561)2.08467737
32Distal lower limb muscle weakness (HP:0009053)2.06829869
33Subacute progressive viral hepatitis (HP:0006572)2.03319164
34Arterial tortuosity (HP:0005116)2.00803498
35Wormian bones (HP:0002645)1.95618925
36Abnormality of the fingertips (HP:0001211)1.95434110
37Fragile skin (HP:0001030)1.94666995
38Lower limb amyotrophy (HP:0007210)1.92099705
39Deep philtrum (HP:0002002)1.91274689
40Abnormality of the Achilles tendon (HP:0005109)1.91076288
41Abnormal ossification of hand bones (HP:0005921)1.90608615
42Distal upper limb amyotrophy (HP:0007149)1.89618905
43Upper limb amyotrophy (HP:0009129)1.89618905
44Shallow orbits (HP:0000586)1.88851648
45Abnormality of the thoracic spine (HP:0100711)1.87627315
46Patellar dislocation (HP:0002999)1.86421240
47Back pain (HP:0003418)1.85741736
48Interstitial pulmonary disease (HP:0006530)1.85536171
49Atrophic scars (HP:0001075)1.84564444
50Heterotopia (HP:0002282)1.84339583
51Right ventricular cardiomyopathy (HP:0011663)1.84080680
52Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.83461245
53Aneurysm (HP:0002617)1.83427001
54Relative macrocephaly (HP:0004482)1.82622498
55Increased variability in muscle fiber diameter (HP:0003557)1.82363077
56Cerebral inclusion bodies (HP:0100314)1.80363962
57Vascular tortuosity (HP:0004948)1.79550902
58Spinal rigidity (HP:0003306)1.79119890
59Natal tooth (HP:0000695)1.78516078
60Germ cell neoplasia (HP:0100728)1.78256758
61Deviation of the thumb (HP:0009603)1.77637049
62Abnormality of skeletal muscle fiber size (HP:0012084)1.77507415
63Dilatation of the ascending aorta (HP:0005111)1.76968232
64Dislocated radial head (HP:0003083)1.76562954
65Blue sclerae (HP:0000592)1.73821404
66Absent frontal sinuses (HP:0002688)1.73015955
67Abnormality of carpal bone ossification (HP:0006257)1.72588185
68Spinal cord compression (HP:0002176)1.70914644
69Colitis (HP:0002583)1.69922266
70Mitral regurgitation (HP:0001653)1.69474804
71Selective tooth agenesis (HP:0001592)1.68176518
72Mitral valve prolapse (HP:0001634)1.67305711
73Long palpebral fissure (HP:0000637)1.67233200
74Macroorchidism (HP:0000053)1.65699010
75Persistence of primary teeth (HP:0006335)1.65318847
76Ankle contracture (HP:0006466)1.64147897
77Esophageal varix (HP:0002040)1.63660155
78Abnormality of the radial head (HP:0003995)1.62078060
79Abnormality of the acetabulum (HP:0003170)1.61806131
80Abnormal foot bone ossification (HP:0010675)1.60459814
81Difficulty climbing stairs (HP:0003551)1.60170846
82Elfin facies (HP:0004428)1.58486093
83Elbow flexion contracture (HP:0002987)1.58354298
84Bladder diverticulum (HP:0000015)1.58162769
85Myocardial infarction (HP:0001658)1.58132747
86Mildly elevated creatine phosphokinase (HP:0008180)1.57275520
87Long eyelashes (HP:0000527)1.57065152
88Micronodular cirrhosis (HP:0001413)1.55642537
89Thoracic kyphosis (HP:0002942)1.54534710
90Obstructive sleep apnea (HP:0002870)1.53411965
91Vertebral arch anomaly (HP:0008438)1.52981385
92Bone pain (HP:0002653)1.52731008
93Missing ribs (HP:0000921)1.52617467
94Pointed chin (HP:0000307)1.52149278
95Aortic aneurysm (HP:0004942)1.51502634
96Cellulitis (HP:0100658)1.50672660
97Abnormality of the calcaneus (HP:0008364)1.48625398
98Joint laxity (HP:0001388)1.47815204
99Renovascular hypertension (HP:0100817)1.47236929
100Mitral stenosis (HP:0001718)1.47221386

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.06131692
2CDK123.75448295
3EEF2K3.58385476
4SMG13.24531825
5ICK3.18053879
6PRPF4B2.81249319
7SCYL22.73354991
8TTN2.30934245
9SIK12.29483390
10IRAK32.19080842
11MST1R2.11070930
12CAMK1D2.10113407
13PKN22.04556077
14ERN11.95543128
15PDGFRA1.92472641
16RIPK11.90244263
17FGFR41.80852968
18MAP3K101.75595287
19EPHA21.71769301
20CAMK1G1.67677591
21MTOR1.42235778
22KSR21.37172179
23PAK41.37031375
24MAP3K131.23028744
25LATS21.21456239
26NME21.16627464
27MET1.15801325
28MAP2K31.11881974
29CDK61.06003557
30PTK21.04010807
31RPS6KB21.02128229
32NEK91.01638085
33PTK60.97331299
34RET0.91184477
35BRD40.85324138
36MARK20.84903294
37PRKD30.84879779
38MAP3K140.84360507
39CDK70.83792743
40PDPK10.82167181
41EPHB10.81497317
42MAP3K60.81404153
43CDC42BPA0.80756689
44TRPM70.79443055
45MAP3K80.79221081
46PAK20.76478706
47PDGFRB0.75563345
48NTRK10.75308346
49RPS6KA20.74479272
50MAP3K20.72715414
51FGFR30.72231214
52TESK10.71465695
53MAPK110.69081545
54CDK40.67737086
55LATS10.67113845
56RIPK40.66977226
57MAP3K10.66739597
58SGK30.62767896
59LMTK20.62276772
60ARAF0.61646212
61PRKD20.60350705
62MAP3K30.60168736
63LRRK20.59264649
64NEK60.55938003
65ZAP700.55036231
66JAK10.53869348
67BMX0.52279124
68RAF10.50219099
69IRAK20.47929977
70TAOK20.47588706
71TAOK10.47371949
72MELK0.46701276
73NEK20.44621949
74MAP3K90.43250602
75PDK10.43162955
76EIF2AK10.42188259
77RPS6KL10.42146823
78RPS6KC10.42146823
79TESK20.42129389
80TYK20.40035438
81CAMKK10.39929128
82FER0.38714740
83AKT20.37332114
84CHEK10.36454985
85PBK0.35023645
86BRAF0.34986445
87STK380.34519965
88TTK0.34486025
89CDK90.33954054
90RPS6KB10.33928313
91TSSK60.33842459
92KSR10.33733279
93ILK0.32597736
94CLK10.32279226
95HIPK20.32073480
96MAP2K20.31885832
97MAPK100.31332426
98JAK30.30941396
99ERBB40.30186064
100MAP3K70.29861281

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.32195364
2Chronic myeloid leukemia_Homo sapiens_hsa052202.28020813
3Non-small cell lung cancer_Homo sapiens_hsa052232.03441246
4Other glycan degradation_Homo sapiens_hsa005112.03258873
5Thyroid cancer_Homo sapiens_hsa052161.92927025
6Acute myeloid leukemia_Homo sapiens_hsa052211.92190227
7Central carbon metabolism in cancer_Homo sapiens_hsa052301.87763277
8Pancreatic cancer_Homo sapiens_hsa052121.86472104
9Endometrial cancer_Homo sapiens_hsa052131.81022970
10Bladder cancer_Homo sapiens_hsa052191.66724593
11Renal cell carcinoma_Homo sapiens_hsa052111.54166061
12Thyroid hormone signaling pathway_Homo sapiens_hsa049191.53533793
13Small cell lung cancer_Homo sapiens_hsa052221.47617845
14VEGF signaling pathway_Homo sapiens_hsa043701.46819717
15Adherens junction_Homo sapiens_hsa045201.45969821
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45556456
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44717161
18Focal adhesion_Homo sapiens_hsa045101.43326652
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.43045113
20Glioma_Homo sapiens_hsa052141.41096335
21Pentose phosphate pathway_Homo sapiens_hsa000301.36395768
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.36279876
23ErbB signaling pathway_Homo sapiens_hsa040121.34640151
24Prostate cancer_Homo sapiens_hsa052151.34057497
25mTOR signaling pathway_Homo sapiens_hsa041501.33993744
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33476294
27Proteoglycans in cancer_Homo sapiens_hsa052051.32874023
28B cell receptor signaling pathway_Homo sapiens_hsa046621.28678489
29Notch signaling pathway_Homo sapiens_hsa043301.26861651
30Insulin signaling pathway_Homo sapiens_hsa049101.24112059
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23746512
32MicroRNAs in cancer_Homo sapiens_hsa052061.23099912
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.22975256
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.20914215
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15765501
36Lysine degradation_Homo sapiens_hsa003101.13341494
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10667199
38Inositol phosphate metabolism_Homo sapiens_hsa005621.09955404
39Colorectal cancer_Homo sapiens_hsa052101.09620607
40Prolactin signaling pathway_Homo sapiens_hsa049171.06950230
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06101243
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.05897994
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.05857656
44Estrogen signaling pathway_Homo sapiens_hsa049151.03478118
45Prion diseases_Homo sapiens_hsa050201.02867871
46Amoebiasis_Homo sapiens_hsa051461.01937244
47Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01829463
48Hepatitis B_Homo sapiens_hsa051610.99357301
49ECM-receptor interaction_Homo sapiens_hsa045120.99253010
50Fructose and mannose metabolism_Homo sapiens_hsa000510.98134322
51AMPK signaling pathway_Homo sapiens_hsa041520.98050589
52Viral carcinogenesis_Homo sapiens_hsa052030.96642701
53Fatty acid biosynthesis_Homo sapiens_hsa000610.95038267
54Choline metabolism in cancer_Homo sapiens_hsa052310.94696980
55Insulin resistance_Homo sapiens_hsa049310.94103749
56GnRH signaling pathway_Homo sapiens_hsa049120.92752076
57Biosynthesis of amino acids_Homo sapiens_hsa012300.90932052
58Hepatitis C_Homo sapiens_hsa051600.90391358
59HIF-1 signaling pathway_Homo sapiens_hsa040660.86592190
60Galactose metabolism_Homo sapiens_hsa000520.86243802
61Apoptosis_Homo sapiens_hsa042100.86019358
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85986767
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.84855412
64Toxoplasmosis_Homo sapiens_hsa051450.81533730
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80473011
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78577069
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.77061153
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.75756080
69Lysosome_Homo sapiens_hsa041420.74441425
70Platelet activation_Homo sapiens_hsa046110.70342727
71Influenza A_Homo sapiens_hsa051640.70081315
72HTLV-I infection_Homo sapiens_hsa051660.69897650
73Endocytosis_Homo sapiens_hsa041440.69691900
74Shigellosis_Homo sapiens_hsa051310.68399118
75N-Glycan biosynthesis_Homo sapiens_hsa005100.67639925
76Carbon metabolism_Homo sapiens_hsa012000.62754415
77Pathways in cancer_Homo sapiens_hsa052000.62627033
78Osteoclast differentiation_Homo sapiens_hsa043800.62590637
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60476042
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59265716
81FoxO signaling pathway_Homo sapiens_hsa040680.59206335
82Cell cycle_Homo sapiens_hsa041100.59203546
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58571350
84Melanoma_Homo sapiens_hsa052180.56938633
85Long-term potentiation_Homo sapiens_hsa047200.56906916
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56024574
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55808510
88Glucagon signaling pathway_Homo sapiens_hsa049220.55330075
89mRNA surveillance pathway_Homo sapiens_hsa030150.54748055
90Thyroid hormone synthesis_Homo sapiens_hsa049180.52469819
91TNF signaling pathway_Homo sapiens_hsa046680.51795530
92Vibrio cholerae infection_Homo sapiens_hsa051100.51702587
93Measles_Homo sapiens_hsa051620.50274969
94T cell receptor signaling pathway_Homo sapiens_hsa046600.49419503
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49190237
96Tight junction_Homo sapiens_hsa045300.48938645
97Renin-angiotensin system_Homo sapiens_hsa046140.47743621
98DNA replication_Homo sapiens_hsa030300.47615887
99Dilated cardiomyopathy_Homo sapiens_hsa054140.47178400
100Salmonella infection_Homo sapiens_hsa051320.46721913

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »