KHDC1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis I (GO:0007141)6.88866737
2meiosis I (GO:0007127)5.95876083
3transcription from mitochondrial promoter (GO:0006390)4.76793824
4regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.72893103
5regulation of DNA methylation (GO:0044030)4.45754979
6positive regulation of protein homooligomerization (GO:0032464)4.41713768
7negative regulation of retinoic acid receptor signaling pathway (GO:0048387)38.9810644
8regulation of retinoic acid receptor signaling pathway (GO:0048385)32.6657667
9autophagic vacuole assembly (GO:0000045)3.93270729
10male meiosis (GO:0007140)3.81205473
11regulation of acrosome reaction (GO:0060046)3.81054877
12mitotic chromosome condensation (GO:0007076)3.77931816
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.72642665
14rRNA modification (GO:0000154)3.71324900
15mitotic metaphase plate congression (GO:0007080)3.67272654
16chaperone-mediated protein transport (GO:0072321)3.61319071
17ribosome assembly (GO:0042255)3.54952392
18attachment of spindle microtubules to kinetochore (GO:0008608)3.46335689
19regulation of G0 to G1 transition (GO:0070316)3.44520819
20multicellular organism reproduction (GO:0032504)3.37732973
21regulation of spindle organization (GO:0090224)3.37551902
22positive regulation of uterine smooth muscle contraction (GO:0070474)3.31229811
23ventricular cardiac muscle cell development (GO:0055015)3.20772640
24regulation of female receptivity (GO:0045924)3.10196506
25aggressive behavior (GO:0002118)3.09393175
26histone H3-K9 demethylation (GO:0033169)3.06907099
27regulation of mitotic spindle organization (GO:0060236)3.05966343
28maturation of SSU-rRNA (GO:0030490)2.99848923
29protein localization to chromosome, centromeric region (GO:0071459)2.97940917
30meiotic cell cycle (GO:0051321)2.96842796
31snRNA transcription (GO:0009301)2.96226399
32rRNA methylation (GO:0031167)2.93319048
33regulation of exit from mitosis (GO:0007096)2.90778248
34drinking behavior (GO:0042756)2.89985722
35metaphase plate congression (GO:0051310)2.88053742
36regulation of female gonad development (GO:2000194)2.86734228
37regulation of histone H3-K9 methylation (GO:0051570)2.83723728
38meiotic nuclear division (GO:0007126)2.80417097
39polyamine biosynthetic process (GO:0006596)2.80186917
40skeletal muscle tissue regeneration (GO:0043403)2.79930369
41termination of RNA polymerase III transcription (GO:0006386)2.78345810
42transcription elongation from RNA polymerase III promoter (GO:0006385)2.78345810
43response to UV-C (GO:0010225)2.73743561
44hyperosmotic salinity response (GO:0042538)2.73332004
45positive regulation of chromosome segregation (GO:0051984)2.70370557
46regulation of cytokine production involved in inflammatory response (GO:1900015)2.69182272
47oocyte development (GO:0048599)2.68948491
48regulation of penile erection (GO:0060405)2.66946426
49female mating behavior (GO:0060180)2.64603064
50positive regulation of catecholamine secretion (GO:0033605)2.63826604
51regulation of RNA export from nucleus (GO:0046831)2.59385118
52ribosomal small subunit biogenesis (GO:0042274)2.59208071
53meiotic cell cycle process (GO:1903046)2.58227007
54positive regulation of cytokinesis (GO:0032467)2.57670829
55negative regulation of reproductive process (GO:2000242)2.55796652
56oocyte maturation (GO:0001556)2.54686137
57positive regulation of histone H3-K4 methylation (GO:0051571)2.51423765
58mitochondrial RNA metabolic process (GO:0000959)2.50966345
59regulation of uterine smooth muscle contraction (GO:0070472)2.50875789
60positive regulation of prostaglandin secretion (GO:0032308)2.50514195
61piRNA metabolic process (GO:0034587)2.49772612
62protein K6-linked ubiquitination (GO:0085020)2.48584591
63chaperone mediated protein folding requiring cofactor (GO:0051085)2.47319901
64N-terminal protein amino acid acetylation (GO:0006474)2.47135824
65positive regulation of cAMP-mediated signaling (GO:0043950)2.44293889
66positive regulation of digestive system process (GO:0060456)2.39300913
67very-low-density lipoprotein particle assembly (GO:0034379)2.39081358
68regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.38522683
69kinetochore assembly (GO:0051382)2.36985407
70protein kinase C signaling (GO:0070528)2.36642919
71regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)2.33113219
72positive regulation of humoral immune response (GO:0002922)2.30697293
73negative regulation of digestive system process (GO:0060457)2.29503839
74reproduction (GO:0000003)2.28858079
75chromosome condensation (GO:0030261)2.27508129
76sleep (GO:0030431)2.26563079
77response to acidic pH (GO:0010447)2.26338554
78nuclear pore complex assembly (GO:0051292)2.25915746
79telomere maintenance via telomere lengthening (GO:0010833)2.25746773
80positive regulation of protein oligomerization (GO:0032461)2.25455944
81rRNA processing (GO:0006364)2.24520558
82transcription from RNA polymerase III promoter (GO:0006383)2.23005782
83DNA replication initiation (GO:0006270)2.20751876
84regulation of cell cycle G2/M phase transition (GO:1902749)2.19447809
85ribosome biogenesis (GO:0042254)2.19422813
86regulation of transforming growth factor beta2 production (GO:0032909)2.18104455
87regulation of protein homooligomerization (GO:0032462)2.17965824
88nuclear pore organization (GO:0006999)2.17043039
89rRNA metabolic process (GO:0016072)2.14042661
90ribonucleoprotein complex biogenesis (GO:0022613)2.12484894
91regulation of meiosis I (GO:0060631)2.10754312
92histone mRNA metabolic process (GO:0008334)2.09068132
93regulation of prostaglandin secretion (GO:0032306)2.08661293
94establishment of chromosome localization (GO:0051303)2.08441014
95CENP-A containing nucleosome assembly (GO:0034080)2.07967753
96nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.07941823
97cellular response to pH (GO:0071467)2.07870425
98retinal cone cell development (GO:0046549)2.07458648
99negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.07340499
100activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.06251469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.58668022
2NOTCH1_21737748_ChIP-Seq_TLL_Human4.78873125
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.77764948
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.77764948
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.77764948
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.65669039
7EZH2_22144423_ChIP-Seq_EOC_Human4.13483783
8E2F7_22180533_ChIP-Seq_HELA_Human4.11511454
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.03431609
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.73979569
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27836061
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.17592733
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.99305881
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.88923782
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.74169526
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69972757
17ZNF274_21170338_ChIP-Seq_K562_Hela2.67695004
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.63490630
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.60966214
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44028113
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.43813468
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.43659526
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31614752
24ETV1_20927104_ChIP-Seq_GIST48_Human2.23815675
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18715088
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07882008
27RBPJ_21746931_ChIP-Seq_IB4_Human2.05850227
28AR_21909140_ChIP-Seq_LNCAP_Human2.05484266
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96477086
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.95059905
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82291387
32TBL1_22424771_ChIP-Seq_293T_Human1.79604220
33PHF8_20622853_ChIP-Seq_HELA_Human1.79266000
34NFYB_21822215_ChIP-Seq_K562_Human1.76304931
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75767189
36ZNF263_19887448_ChIP-Seq_K562_Human1.72861564
37TTF2_22483619_ChIP-Seq_HELA_Human1.67810946
38GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.67338985
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64540633
40GATA6_21074721_ChIP-Seq_CACO-2_Human1.62472196
41VDR_23849224_ChIP-Seq_CD4+_Human1.62004184
42CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.60507415
43MYC_18940864_ChIP-ChIP_HL60_Human1.56370109
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.54595233
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53201411
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52660058
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47799531
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.45958763
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45548701
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43039727
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42380388
52XRN2_22483619_ChIP-Seq_HELA_Human1.39901163
53HNFA_21074721_ChIP-Seq_CACO-2_Human1.39028685
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33625035
55GABP_19822575_ChIP-Seq_HepG2_Human1.32093872
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.26999158
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23594490
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20878634
59FOXP3_21729870_ChIP-Seq_TREG_Human1.16767774
60NFYA_21822215_ChIP-Seq_K562_Human1.15964581
61KAP1_22055183_ChIP-Seq_ESCs_Mouse1.09655866
62LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02934600
63RAC3_21632823_ChIP-Seq_H3396_Human1.02909652
64CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02639606
65LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02088697
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01551631
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98282827
68PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98173985
69TP53_22573176_ChIP-Seq_HFKS_Human0.98147304
70CIITA_25753668_ChIP-Seq_RAJI_Human0.94636996
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92563841
72MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91295909
73KDM5A_27292631_Chip-Seq_BREAST_Human0.90814823
74IRF1_19129219_ChIP-ChIP_H3396_Human0.89099542
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86408797
76STAT1_20625510_ChIP-Seq_HELA_Human0.85971983
77CTCF_20526341_ChIP-Seq_ESCs_Human0.85887842
78STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.85852221
79ELK1_19687146_ChIP-ChIP_HELA_Human0.84738593
80SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83912318
81ELK1_22589737_ChIP-Seq_MCF10A_Human0.83898306
82NANOG_20526341_ChIP-Seq_ESCs_Human0.83452753
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81290028
84HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80850132
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.78497640
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.77532910
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76905728
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.75622317
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.74543187
90E2F1_21310950_ChIP-Seq_MCF-7_Human0.74179815
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73230544
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72580283
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.71930398
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.71670109
95KLF4_18555785_ChIP-Seq_MESCs_Mouse0.68829746
96E2F1_18555785_ChIP-Seq_MESCs_Mouse0.67970645
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.67831354
98CTCF_21964334_Chip-Seq_Bcells_Human0.66814188
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.65553494
100E2F1_20622854_ChIP-Seq_HELA_Human0.64878199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity6.91854645
2MP0005423_abnormal_somatic_nervous6.20401280
3MP0006292_abnormal_olfactory_placode5.41507552
4MP0003718_maternal_effect4.54752886
5MP0009379_abnormal_foot_pigmentation3.46804635
6MP0003693_abnormal_embryo_hatching3.33690602
7MP0005499_abnormal_olfactory_system2.88671597
8MP0005394_taste/olfaction_phenotype2.88671597
9MP0008260_abnormal_autophagy2.82119655
10MP0010307_abnormal_tumor_latency2.81544193
11MP0004957_abnormal_blastocyst_morpholog2.72556769
12MP0003111_abnormal_nucleus_morphology2.68610404
13MP0002127_abnormal_cardiovascular_syste2.66871006
14MP0010030_abnormal_orbit_morphology2.49242571
15MP0003077_abnormal_cell_cycle2.39162892
16MP0002160_abnormal_reproductive_system2.36691126
17MP0002277_abnormal_respiratory_mucosa2.27496692
18MP0009333_abnormal_splenocyte_physiolog2.11765033
19MP0001929_abnormal_gametogenesis2.11328975
20MP0008057_abnormal_DNA_replication2.10415679
21MP0010094_abnormal_chromosome_stability2.02804457
22MP0003646_muscle_fatigue2.02613363
23MP0008877_abnormal_DNA_methylation1.98366808
24MP0002210_abnormal_sex_determination1.98114574
25MP0008058_abnormal_DNA_repair1.97834019
26MP0008789_abnormal_olfactory_epithelium1.89418959
27MP0005410_abnormal_fertilization1.77684220
28MP0005395_other_phenotype1.70779951
29MP0005389_reproductive_system_phenotype1.58671360
30MP0001881_abnormal_mammary_gland1.53668649
31MP0003136_yellow_coat_color1.52460534
32MP0009840_abnormal_foam_cell1.48719596
33MP0003699_abnormal_female_reproductive1.42617106
34MP0001672_abnormal_embryogenesis/_devel1.41159934
35MP0005380_embryogenesis_phenotype1.41159934
36MP0003121_genomic_imprinting1.32611465
37MP0002161_abnormal_fertility/fecundity1.31729248
38MP0008932_abnormal_embryonic_tissue1.30148513
39MP0002138_abnormal_hepatobiliary_system1.29806793
40MP0000653_abnormal_sex_gland1.27659606
41MP0001730_embryonic_growth_arrest1.26574054
42MP0006276_abnormal_autonomic_nervous1.25269133
43MP0000350_abnormal_cell_proliferation1.23965232
44MP0003698_abnormal_male_reproductive1.22700673
45MP0001293_anophthalmia1.20012790
46MP0003984_embryonic_growth_retardation1.16821017
47MP0001145_abnormal_male_reproductive1.14828317
48MP0005647_abnormal_sex_gland1.12800238
49MP0006036_abnormal_mitochondrial_physio1.12740057
50MP0003938_abnormal_ear_development1.12392762
51MP0002088_abnormal_embryonic_growth/wei1.10449460
52MP0005360_urolithiasis1.09551437
53MP0000049_abnormal_middle_ear1.09047572
54MP0001697_abnormal_embryo_size1.01145344
55MP0002234_abnormal_pharynx_morphology0.99574547
56MP0002254_reproductive_system_inflammat0.97724358
57MP0010368_abnormal_lymphatic_system0.90743710
58MP0002233_abnormal_nose_morphology0.90717288
59MP0001666_abnormal_nutrient_absorption0.90582294
60MP0000358_abnormal_cell_content/0.89762397
61MP0001502_abnormal_circadian_rhythm0.83900446
62MP0008995_early_reproductive_senescence0.83838566
63MP0003890_abnormal_embryonic-extraembry0.81434989
64MP0000372_irregular_coat_pigmentation0.80255949
65MP0005397_hematopoietic_system_phenotyp0.77470246
66MP0001545_abnormal_hematopoietic_system0.77470246
67MP0000627_abnormal_mammary_gland0.76312096
68MP0005646_abnormal_pituitary_gland0.75571363
69MP0002085_abnormal_embryonic_tissue0.75468436
70MP0001119_abnormal_female_reproductive0.75239424
71MP0003936_abnormal_reproductive_system0.75219913
72MP0002080_prenatal_lethality0.74982324
73MP0003119_abnormal_digestive_system0.73352102
74MP0000750_abnormal_muscle_regeneration0.72983848
75MP0006035_abnormal_mitochondrial_morpho0.72136236
76MP0000762_abnormal_tongue_morphology0.71458092
77MP0001286_abnormal_eye_development0.71288654
78MP0002084_abnormal_developmental_patter0.68313615
79MP0005451_abnormal_body_composition0.68209086
80MP0002751_abnormal_autonomic_nervous0.64652356
81MP0003755_abnormal_palate_morphology0.61577691
82MP0002873_normal_phenotype0.60175045
83MP0002169_no_abnormal_phenotype0.60039431
84MP0000313_abnormal_cell_death0.59672873
85MP0002086_abnormal_extraembryonic_tissu0.59305853
86MP0003828_pulmonary_edema0.58914227
87MP0000490_abnormal_crypts_of0.58085546
88MP0001919_abnormal_reproductive_system0.57239663
89MP0004215_abnormal_myocardial_fiber0.56446495
90MP0000631_abnormal_neuroendocrine_gland0.55991080
91MP0005197_abnormal_uvea_morphology0.55798357
92MP0004019_abnormal_vitamin_homeostasis0.55704492
93MP0000428_abnormal_craniofacial_morphol0.55619468
94MP0004381_abnormal_hair_follicle0.55046919
95MP0000678_abnormal_parathyroid_gland0.54678473
96MP0003879_abnormal_hair_cell0.50836926
97MP0003195_calcinosis0.48905053
98MP0003935_abnormal_craniofacial_develop0.48820949
99MP0002163_abnormal_gland_morphology0.48745646
100MP0003943_abnormal_hepatobiliary_system0.48083113

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)8.04619101
2Premature ovarian failure (HP:0008209)4.54861612
3Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.49445071
4Patent foramen ovale (HP:0001655)4.42766788
5Hypercortisolism (HP:0001578)4.35005463
6Congenital malformation of the right heart (HP:0011723)4.32880321
7Double outlet right ventricle (HP:0001719)4.32880321
8Carpal bone hypoplasia (HP:0001498)4.27053389
9Malnutrition (HP:0004395)4.20396805
10Abnormal pancreas size (HP:0012094)4.05498706
11Birth length less than 3rd percentile (HP:0003561)4.05428237
12Aplasia/hypoplasia of the uterus (HP:0008684)3.78941889
13Periauricular skin pits (HP:0100277)3.77842721
14Preauricular pit (HP:0004467)3.77842721
15Abnormality of the septum pellucidum (HP:0007375)3.74280122
16Abnormal umbilical cord blood vessels (HP:0011403)3.68184101
17Single umbilical artery (HP:0001195)3.68184101
18Abnormality of the fetal cardiovascular system (HP:0010948)3.68184101
19Short tibia (HP:0005736)3.63402838
20Ureteral duplication (HP:0000073)3.29641290
21Abnormality of the aortic arch (HP:0012303)3.25835225
22Aplasia/Hypoplasia of the tibia (HP:0005772)3.23136232
23Aplasia/Hypoplasia involving the musculature (HP:0001460)3.17454760
24Impulsivity (HP:0100710)3.14320373
25Abnormality of abdominal situs (HP:0011620)3.09057069
26Abdominal situs inversus (HP:0003363)3.09057069
27Midline defect of the nose (HP:0004122)3.01401846
28Absent septum pellucidum (HP:0001331)3.00696624
29Infertility (HP:0000789)2.99766644
30Hypophosphatemic rickets (HP:0004912)2.99594624
31Hypoglycemic seizures (HP:0002173)2.95953603
32Hypoplasia of the uterus (HP:0000013)2.91276469
33Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.90419664
34Hypergonadotropic hypogonadism (HP:0000815)2.83466668
35Facial cleft (HP:0002006)2.82803947
36Reticulocytopenia (HP:0001896)2.81973646
37Microvesicular hepatic steatosis (HP:0001414)2.73756244
38Progressive muscle weakness (HP:0003323)2.72025591
39Aplasia/hypoplasia of the humerus (HP:0006507)2.67889635
40Sensory axonal neuropathy (HP:0003390)2.66171365
41Microretrognathia (HP:0000308)2.64881316
42Stenosis of the external auditory canal (HP:0000402)2.61688202
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.61639995
44Osteomalacia (HP:0002749)2.61625803
45Fused cervical vertebrae (HP:0002949)2.60879351
46Septo-optic dysplasia (HP:0100842)2.59718698
47Ileus (HP:0002595)2.56740171
48Cleft eyelid (HP:0000625)2.55294131
49Rhinitis (HP:0012384)2.55193361
50Skin pits (HP:0100276)2.54256666
51Chromsome breakage (HP:0040012)2.50839701
52Meckel diverticulum (HP:0002245)2.47909033
53Constricted visual fields (HP:0001133)2.47008455
54Abnormality of the preputium (HP:0100587)2.44639753
55Absent radius (HP:0003974)2.43741647
56Dysphonia (HP:0001618)2.42786977
57Glossoptosis (HP:0000162)2.41515141
58Abnormality of the ileum (HP:0001549)2.38673377
59Muscle stiffness (HP:0003552)2.37399033
60Horseshoe kidney (HP:0000085)2.37391161
61Adrenal overactivity (HP:0002717)2.35186515
62Abnormal number of incisors (HP:0011064)2.34899397
63Abnormality of cells of the erythroid lineage (HP:0012130)2.34861032
64Hyperglycemia (HP:0003074)2.32952829
65Myopathic facies (HP:0002058)2.30507880
66Aplasia involving forearm bones (HP:0009822)2.29971539
67Absent forearm bone (HP:0003953)2.29971539
68Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28824771
69Multiple enchondromatosis (HP:0005701)2.24226973
70Anhidrosis (HP:0000970)2.22047945
71Absent thumb (HP:0009777)2.19517324
72Myokymia (HP:0002411)2.14421802
73Tetraparesis (HP:0002273)2.12728922
74Dysautonomia (HP:0002459)2.12023999
75Abnormal number of erythroid precursors (HP:0012131)2.11968251
76Testicular atrophy (HP:0000029)2.11454388
77Sparse lateral eyebrow (HP:0005338)2.11357716
78Symptomatic seizures (HP:0011145)2.10910613
79Supernumerary spleens (HP:0009799)2.08031899
80Median cleft lip (HP:0000161)2.06846528
81Abnormality of the umbilical cord (HP:0010881)2.06768724
82Progressive hearing impairment (HP:0001730)2.04795951
83Hypoplasia of the radius (HP:0002984)2.04753013
84Concave nail (HP:0001598)1.99419565
85Atresia of the external auditory canal (HP:0000413)1.97999230
86Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95569261
87Progressive sensorineural hearing impairment (HP:0000408)1.92707269
88Mitral stenosis (HP:0001718)1.88997693
89Breast hypoplasia (HP:0003187)1.88079704
90Abnormal biliary tract morphology (HP:0012440)1.85027073
91Short thumb (HP:0009778)1.83680340
92Cortical visual impairment (HP:0100704)1.83211080
93Reduced antithrombin III activity (HP:0001976)1.81486844
94Selective tooth agenesis (HP:0001592)1.81039746
95Steatorrhea (HP:0002570)1.80329019
96Truncus arteriosus (HP:0001660)1.77729600
97Ragged-red muscle fibers (HP:0003200)1.77590282
98Spinal cord lesions (HP:0100561)1.76542478
99Syringomyelia (HP:0003396)1.76542478
100Posterior subcapsular cataract (HP:0007787)1.76411504

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.10907320
2LATS25.00870945
3TESK24.69649120
4SRPK14.51939169
5STK162.93744350
6TRIM282.86571379
7NEK62.58442271
8BRSK12.51540183
9DYRK32.46797789
10PLK12.44649055
11CDK192.29970056
12PBK2.20674155
13CDK92.17486281
14AURKA2.10182946
15TAOK32.03942555
16BRSK22.02197890
17AURKB1.95969591
18PLK31.84643080
19CDK121.82136794
20CDC71.81219960
21MARK31.75533848
22PIM21.64806721
23PDK21.54855660
24CHEK11.41100837
25RAF11.32671687
26CDK71.31527221
27NEK21.31299414
28GSK3A1.27273754
29PLK41.27223195
30TTK1.24227657
31PRKCI1.19313388
32PIM11.18869282
33MELK1.16750257
34WNK31.12432693
35CHEK21.11632302
36PKN11.06429211
37PAK21.03604620
38CSNK1E1.03462640
39BMX1.03388662
40LRRK20.94361383
41STK40.93731723
42PAK10.93268789
43MAP3K90.92291593
44MAP3K50.88867455
45CSNK2A10.88655498
46CDK20.85234560
47CSNK2A20.84109353
48PAK60.82070645
49CDK10.76947895
50STK30.75469869
51ZAK0.74687408
52ATR0.72991143
53MTOR0.71226407
54WNK10.70194600
55TNIK0.68074222
56TESK10.65825242
57MAPK110.64631743
58STK100.64028854
59NTRK30.63865169
60TLK10.59573677
61PRKG10.56090588
62ATM0.56068217
63KDR0.52919339
64BRD40.52410375
65VRK10.50311551
66RPS6KA10.50137227
67PRKACB0.49359784
68AKT20.47207547
69PRKD10.46167192
70PRKD20.45886022
71MAP3K80.44982420
72MAPK10.44491074
73GSK3B0.44014819
74EIF2AK30.43954276
75NUAK10.42046928
76EPHA40.41907259
77NME10.41611242
78WEE10.39129022
79STK240.38776749
80MAPK140.35610952
81TAOK20.34182780
82ABL20.28931383
83TBK10.28425438
84CSNK1A10.28032350
85PRKAA10.26057089
86MAP3K40.25631764
87PRKACA0.24854140
88CSNK1D0.23985263
89CDK11A0.23362881
90PINK10.22519264
91CDK30.21122175
92MAPK100.20826135
93DMPK0.20601969
94MAPKAPK20.20021094
95ERBB40.19272218
96CAMK40.17345192
97CDK50.16565403
98LMTK20.16057525
99AKT10.15711516
100PRKCA0.13566158

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030225.14980747
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.90727808
3Regulation of autophagy_Homo sapiens_hsa041404.65785673
4Ribosome_Homo sapiens_hsa030104.10697864
5RNA polymerase_Homo sapiens_hsa030203.87351882
6mRNA surveillance pathway_Homo sapiens_hsa030153.58396193
7RNA transport_Homo sapiens_hsa030133.17575887
8Cell cycle_Homo sapiens_hsa041102.95318550
9Folate biosynthesis_Homo sapiens_hsa007902.67152538
10Spliceosome_Homo sapiens_hsa030402.66183418
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.60252788
12p53 signaling pathway_Homo sapiens_hsa041152.58687320
13Oocyte meiosis_Homo sapiens_hsa041142.37296052
14Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.98362701
15Mismatch repair_Homo sapiens_hsa034301.84507085
16Taste transduction_Homo sapiens_hsa047421.63400706
17Fanconi anemia pathway_Homo sapiens_hsa034601.57672920
18Pyrimidine metabolism_Homo sapiens_hsa002401.56661875
19Homologous recombination_Homo sapiens_hsa034401.53344038
20RNA degradation_Homo sapiens_hsa030181.50260522
21DNA replication_Homo sapiens_hsa030301.42150593
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36079275
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.35503827
24Base excision repair_Homo sapiens_hsa034101.34032585
25Steroid biosynthesis_Homo sapiens_hsa001001.22864953
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22845501
27Huntingtons disease_Homo sapiens_hsa050161.14023425
28Sulfur metabolism_Homo sapiens_hsa009201.05967459
29Fatty acid elongation_Homo sapiens_hsa000621.05412490
30MicroRNAs in cancer_Homo sapiens_hsa052061.02147592
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01644793
32Purine metabolism_Homo sapiens_hsa002301.01407911
33Viral carcinogenesis_Homo sapiens_hsa052030.98035699
34Inositol phosphate metabolism_Homo sapiens_hsa005620.96948134
35Cardiac muscle contraction_Homo sapiens_hsa042600.95051961
36Epstein-Barr virus infection_Homo sapiens_hsa051690.89668502
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88939063
38Dorso-ventral axis formation_Homo sapiens_hsa043200.87094126
39Ovarian steroidogenesis_Homo sapiens_hsa049130.86350591
40Caffeine metabolism_Homo sapiens_hsa002320.86166469
41Herpes simplex infection_Homo sapiens_hsa051680.82106983
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80597210
43Wnt signaling pathway_Homo sapiens_hsa043100.77547127
44Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77135771
45Nucleotide excision repair_Homo sapiens_hsa034200.72593385
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.72274869
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.70986051
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70887557
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64733652
50Fatty acid biosynthesis_Homo sapiens_hsa000610.62927392
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62136017
52Parkinsons disease_Homo sapiens_hsa050120.57521622
53Hepatitis B_Homo sapiens_hsa051610.56716134
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53977466
55Insulin secretion_Homo sapiens_hsa049110.51751665
56Small cell lung cancer_Homo sapiens_hsa052220.51472534
57Arginine and proline metabolism_Homo sapiens_hsa003300.48876128
58Olfactory transduction_Homo sapiens_hsa047400.48370763
59AMPK signaling pathway_Homo sapiens_hsa041520.41466403
60Systemic lupus erythematosus_Homo sapiens_hsa053220.40544308
61FoxO signaling pathway_Homo sapiens_hsa040680.37619512
62Glutathione metabolism_Homo sapiens_hsa004800.37584439
63Bile secretion_Homo sapiens_hsa049760.36518833
64Hippo signaling pathway_Homo sapiens_hsa043900.35516873
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34953371
66Acute myeloid leukemia_Homo sapiens_hsa052210.33827878
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31838800
68Nicotine addiction_Homo sapiens_hsa050330.30562089
69Protein export_Homo sapiens_hsa030600.30407794
70Proteasome_Homo sapiens_hsa030500.29911773
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29851992
72Protein digestion and absorption_Homo sapiens_hsa049740.28787623
73Alcoholism_Homo sapiens_hsa050340.27606502
74TGF-beta signaling pathway_Homo sapiens_hsa043500.27172804
75Hedgehog signaling pathway_Homo sapiens_hsa043400.24451347
76Renal cell carcinoma_Homo sapiens_hsa052110.24387660
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23129707
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23070751
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.22511252
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21697501
81Circadian rhythm_Homo sapiens_hsa047100.20754698
82Prostate cancer_Homo sapiens_hsa052150.20128706
83Mineral absorption_Homo sapiens_hsa049780.17150213
84Adherens junction_Homo sapiens_hsa045200.15157785
85ABC transporters_Homo sapiens_hsa020100.12178344
86Metabolic pathways_Homo sapiens_hsa011000.11459644
87Apoptosis_Homo sapiens_hsa042100.11048186
88GABAergic synapse_Homo sapiens_hsa047270.10442065
89Pathways in cancer_Homo sapiens_hsa052000.10045725
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08855870
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.07677645
92Tight junction_Homo sapiens_hsa045300.06773484
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.06506082
94Legionellosis_Homo sapiens_hsa051340.04454465
95mTOR signaling pathway_Homo sapiens_hsa041500.04387841
96Serotonergic synapse_Homo sapiens_hsa047260.04179896
97Influenza A_Homo sapiens_hsa051640.04077672
98HTLV-I infection_Homo sapiens_hsa051660.04045409
99Synaptic vesicle cycle_Homo sapiens_hsa047210.02889106
100Sphingolipid metabolism_Homo sapiens_hsa006000.01666585

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