KERA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1camera-type eye morphogenesis (GO:0048593)9.36894348
2myoblast migration (GO:0051451)8.64361222
3peripheral nervous system axon ensheathment (GO:0032292)7.21490379
4myelination in peripheral nervous system (GO:0022011)7.21490379
5extracellular matrix assembly (GO:0085029)7.18872867
6negative regulation of stress fiber assembly (GO:0051497)7.12729197
7eye morphogenesis (GO:0048592)6.78412787
8endocardial cushion morphogenesis (GO:0003203)6.58718830
9negative regulation of Rho protein signal transduction (GO:0035024)6.53884725
10embryonic camera-type eye development (GO:0031076)6.44269205
11protein heterotrimerization (GO:0070208)6.40275075
12* keratan sulfate catabolic process (GO:0042340)6.20662310
13G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071995.84312406
14collagen fibril organization (GO:0030199)5.69846357
15venous blood vessel morphogenesis (GO:0048845)5.62159339
16negative regulation of embryonic development (GO:0045992)5.51954607
17myoblast fusion (GO:0007520)5.47499990
18ventricular cardiac muscle cell development (GO:0055015)5.23221581
19negative regulation of actin filament bundle assembly (GO:0032232)5.19104528
20mesenchyme morphogenesis (GO:0072132)5.09035352
21epithelial cell-cell adhesion (GO:0090136)5.07391353
22muscle cell migration (GO:0014812)5.06269776
23bone trabecula formation (GO:0060346)5.04366992
24neuronal ion channel clustering (GO:0045161)4.99377464
25regulation of heart morphogenesis (GO:2000826)4.87420492
26planar cell polarity pathway involved in neural tube closure (GO:0090179)4.84677337
27endothelial cell morphogenesis (GO:0001886)4.84630581
28syncytium formation by plasma membrane fusion (GO:0000768)4.78441569
29positive regulation of neutrophil migration (GO:1902624)4.78415457
30positive regulation of neutrophil chemotaxis (GO:0090023)4.78415457
31complement activation, alternative pathway (GO:0006957)4.63885513
32extracellular fibril organization (GO:0043206)4.62297238
33sequestering of extracellular ligand from receptor (GO:0035581)4.59845232
34positive regulation of granulocyte chemotaxis (GO:0071624)4.57101669
35female gonad development (GO:0008585)4.55556949
36cell differentiation involved in metanephros development (GO:0072202)4.50499839
37striated muscle adaptation (GO:0014888)4.49593675
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.43940483
39actin-myosin filament sliding (GO:0033275)4.27003263
40muscle filament sliding (GO:0030049)4.27003263
41collagen metabolic process (GO:0032963)4.24407517
42regulation of skeletal muscle contraction (GO:0014819)4.23128892
43fibril organization (GO:0097435)4.21989195
44regulation of mitochondrial depolarization (GO:0051900)4.20091128
45striated muscle cell proliferation (GO:0014855)4.18352024
46cardiac muscle cell proliferation (GO:0060038)4.15249208
47outflow tract septum morphogenesis (GO:0003148)4.13528136
48positive regulation of focal adhesion assembly (GO:0051894)4.13106216
49positive regulation of cell junction assembly (GO:1901890)4.13106216
50muscle cell proliferation (GO:0033002)4.11823692
51lung-associated mesenchyme development (GO:0060484)4.08795128
52collagen catabolic process (GO:0030574)4.04261107
53embryonic hindlimb morphogenesis (GO:0035116)4.03291438
54multicellular organismal macromolecule metabolic process (GO:0044259)4.00898369
55positive regulation of adherens junction organization (GO:1903393)3.97404844
56striated muscle hypertrophy (GO:0014897)3.96961743
57syncytium formation (GO:0006949)3.90268543
58hair cell differentiation (GO:0035315)3.85528779
59multicellular organismal metabolic process (GO:0044236)3.84132319
60lung morphogenesis (GO:0060425)3.83399167
61vitamin A metabolic process (GO:0006776)3.81955509
62phagocytosis, recognition (GO:0006910)3.79476701
63muscle adaptation (GO:0043500)3.79464068
64smooth muscle cell differentiation (GO:0051145)3.79247752
65cellular sodium ion homeostasis (GO:0006883)3.77263111
66actin-mediated cell contraction (GO:0070252)3.76340684
67multicellular organismal catabolic process (GO:0044243)3.73995594
68negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.73345575
69embryonic digestive tract morphogenesis (GO:0048557)3.73124672
70cranial suture morphogenesis (GO:0060363)3.70956759
71non-canonical Wnt signaling pathway (GO:0035567)3.66893621
72muscle cell fate commitment (GO:0042693)3.65748293
73protein targeting to plasma membrane (GO:0072661)3.64946454
74skin morphogenesis (GO:0043589)3.64945119
75neural crest cell migration (GO:0001755)3.64541089
76positive regulation of smoothened signaling pathway (GO:0045880)3.64061439
77muscle hypertrophy (GO:0014896)3.61046273
78positive regulation of p38MAPK cascade (GO:1900745)3.60932511
79cellular response to cadmium ion (GO:0071276)3.58395265
80* keratan sulfate metabolic process (GO:0042339)3.57380542
81regulation of gastrulation (GO:0010470)3.57321170
82glomerular filtration (GO:0003094)3.56070373
83negative regulation of cartilage development (GO:0061037)3.55323279
84negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.54827434
85peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.50626746
86dorsal/ventral neural tube patterning (GO:0021904)3.50222461
87negative regulation of DNA repair (GO:0045738)3.47315663
88positive regulation of gastrulation (GO:2000543)3.46573338
89regulation of neutrophil chemotaxis (GO:0090022)3.45878968
90regulation of neutrophil migration (GO:1902622)3.45878968
91regulation of Rho protein signal transduction (GO:0035023)3.44234631
92wound healing, spreading of epidermal cells (GO:0035313)3.42906342
93skeletal muscle fiber development (GO:0048741)3.42020648
94skin development (GO:0043588)3.40347342
95regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.40284587
96regulation of histone phosphorylation (GO:0033127)3.39138680
97hindlimb morphogenesis (GO:0035137)3.37007772
98positive regulation of epithelial to mesenchymal transition (GO:0010718)3.35520967
99midgut development (GO:0007494)3.35087844
100regulation of complement activation (GO:0030449)3.34809942
101left/right axis specification (GO:0070986)3.33976322
102craniofacial suture morphogenesis (GO:0097094)3.33813248
103skeletal muscle contraction (GO:0003009)3.33785639
104cardiac septum morphogenesis (GO:0060411)3.30966832
105regulation of plasminogen activation (GO:0010755)3.30614607
106Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.29404375
107renal filtration (GO:0097205)3.27298539
108blood vessel maturation (GO:0001955)3.24752756
109digestive tract morphogenesis (GO:0048546)3.21969427
110sarcoplasmic reticulum calcium ion transport (GO:0070296)3.21379502
111regulation of p38MAPK cascade (GO:1900744)3.19981837
112chondrocyte proliferation (GO:0035988)3.18344577
113negative regulation of cell-matrix adhesion (GO:0001953)3.12950949
114regulation of establishment of planar polarity (GO:0090175)3.11359028
115barbed-end actin filament capping (GO:0051016)3.09856468
116extracellular matrix disassembly (GO:0022617)3.08370939
117regulation of fibroblast migration (GO:0010762)3.08029831
118detection of molecule of bacterial origin (GO:0032490)3.05729033
119positive regulation of fatty acid oxidation (GO:0046321)3.03904042
120exocrine pancreas development (GO:0031017)3.03009344
121establishment of nucleus localization (GO:0040023)3.01198249
122regulation of protein activation cascade (GO:2000257)3.00885683
123actin filament-based movement (GO:0030048)3.00485899
124mesenchymal to epithelial transition (GO:0060231)2.96349710
125negative regulation of skeletal muscle tissue development (GO:0048642)2.95067775
126negative regulation of cardiac muscle tissue growth (GO:0055022)2.94937659
127negative regulation of heart growth (GO:0061117)2.94937659
128face morphogenesis (GO:0060325)2.94665977
129outer ear morphogenesis (GO:0042473)2.93855482
130positive regulation of Rho protein signal transduction (GO:0035025)2.93123822
131regulation of alkaline phosphatase activity (GO:0010692)2.91925146
132* keratan sulfate biosynthetic process (GO:0018146)2.91818954
133glandular epithelial cell development (GO:0002068)2.91495903
134paraxial mesoderm development (GO:0048339)2.90742490
135embryonic cranial skeleton morphogenesis (GO:0048701)2.89250734
136myotube cell development (GO:0014904)2.87896456
137response to vitamin A (GO:0033189)2.87403648
138behavioral response to pain (GO:0048266)2.86991891
139positive regulation of mesenchymal cell proliferation (GO:0002053)2.86640679
140extracellular negative regulation of signal transduction (GO:1900116)2.85528507
141extracellular regulation of signal transduction (GO:1900115)2.85528507
142negative regulation of interleukin-8 production (GO:0032717)2.84840368
143cellular response to amino acid stimulus (GO:0071230)2.81483578
144positive regulation of cartilage development (GO:0061036)2.80765166
145glomerular basement membrane development (GO:0032836)2.80551324
146regulation of granulocyte chemotaxis (GO:0071622)2.78513843
147positive regulation of transcription regulatory region DNA binding (GO:2000679)2.78335049
148extracellular matrix organization (GO:0030198)2.78166146
149extracellular structure organization (GO:0043062)2.77193097
150ventricular septum morphogenesis (GO:0060412)2.76486012
151plasma membrane repair (GO:0001778)2.75990410
152negative regulation of muscle hypertrophy (GO:0014741)2.75073896
153endodermal cell differentiation (GO:0035987)2.74714227
154dopaminergic neuron differentiation (GO:0071542)2.73195549
155positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.72835396
156skeletal muscle tissue regeneration (GO:0043403)2.72196749
157positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.69624671
158negative regulation of chondrocyte differentiation (GO:0032331)2.69535553
159bone development (GO:0060348)2.68764472
160positive regulation of cardiac muscle cell proliferation (GO:0060045)2.68700043
161cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.68259444
162dermatan sulfate biosynthetic process (GO:0030208)2.66700520
163myofibril assembly (GO:0030239)2.63759052
164positive regulation of fatty acid beta-oxidation (GO:0032000)2.63316422
165neuron projection extension involved in neuron projection guidance (GO:1902284)2.62584935
166axon extension involved in axon guidance (GO:0048846)2.62584935
167negative regulation of angiogenesis (GO:0016525)2.61849381
168skeletal muscle adaptation (GO:0043501)11.2126306
169cell migration involved in heart development (GO:0060973)10.1012749

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.39612059
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.39063065
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.79674273
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.83679096
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.68992777
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.66645078
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.64045198
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.57653000
9TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.46782654
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43852565
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.30581251
12CLOCK_20551151_ChIP-Seq_293T_Human2.28369134
13CJUN_26792858_Chip-Seq_BT549_Human2.26121313
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21481255
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.05361263
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.05361263
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.05160632
18ERG_21242973_ChIP-ChIP_JURKAT_Human2.04624745
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.04302738
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.97252000
21BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.97238175
22* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.95630381
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.95566067
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.88359489
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87371929
26EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.86550691
27EGR1_19032775_ChIP-ChIP_M12_Human1.85396121
28AR_21572438_ChIP-Seq_LNCaP_Human1.80884618
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.77696434
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.77634814
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76541298
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75005209
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.72503312
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.72437622
35CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67433861
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.64808715
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.63991504
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.63733296
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63471116
40RING1B_27294783_Chip-Seq_NPCs_Mouse1.61485833
41STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.61120388
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.60812157
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60372481
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59646988
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59487411
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.58394816
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57492813
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53686092
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51717968
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51231740
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50107677
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48157942
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46167999
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46167999
55BRD4_25478319_ChIP-Seq_HGPS_Human1.44877599
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.43501726
57CTCF_27219007_Chip-Seq_Bcells_Human1.42424944
58TBX3_20139965_ChIP-Seq_ESCs_Mouse1.42010959
59TBX3_20139965_ChIP-Seq_MESCs_Mouse1.41217582
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39643442
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38402283
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37513712
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35390909
64LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33937277
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31353485
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31353485
67DROSHA_22980978_ChIP-Seq_HELA_Human1.30935526
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.30532499
69EZH2_22144423_ChIP-Seq_EOC_Human1.29591197
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.28906827
71TBX20_22328084_ChIP-Seq_HEART_Mouse1.28906827
72TP53_18474530_ChIP-ChIP_U2OS_Human1.28808247
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28302198
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.25946471
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.25077875
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23338675
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23049612
78TP53_16413492_ChIP-PET_HCT116_Human1.22228439
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20299951
80MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.19217090
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18736655
82SMC1_22415368_ChIP-Seq_MEFs_Mouse1.18017800
83TP53_20018659_ChIP-ChIP_R1E_Mouse1.15171882
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15168283
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.13982925
86SA1_22415368_ChIP-Seq_MEFs_Mouse1.13601140
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13538538
88SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13298038
89SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12124782
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.11307727
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.10391080
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09913908
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09705521
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08914395
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08754908
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07696258
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07213642
98KDM2B_26808549_Chip-Seq_K562_Human1.05753169
99MYC_27129775_Chip-Seq_CORNEA_Mouse1.05634483
100VDR_24787735_ChIP-Seq_THP-1_Human1.05284437
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.05063454
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04308966
103JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04074257
104TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03949756
105MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03535896
106PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02876106
107ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02089748
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01205845
109RING1B_27294783_Chip-Seq_ESCs_Mouse1.00742716
110EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99588059
111NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98447572
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98421234
113KDM2B_26808549_Chip-Seq_REH_Human0.97990699
114SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97624866
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97321468
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97279473
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97056684
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96837871
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95704486
120KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95225975
121UBF1/2_26484160_Chip-Seq_HMECs_Human0.95049985
122SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94744965
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94634797
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93946609
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93864532
126ELK3_25401928_ChIP-Seq_HUVEC_Human0.92661191
127P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92517049
128SALL1_21062744_ChIP-ChIP_HESCs_Human0.91986952
129HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91910056
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90500830
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.90111897
132NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89235299
133DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88933557
134OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88917331
135SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88775926
136POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88548618
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86926082
138NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85490331
139ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84168438
140CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83906369
141AR_25329375_ChIP-Seq_VCAP_Human0.83382901
142SOX2_20726797_ChIP-Seq_SW620_Human0.83267193
143TCF4_18268006_ChIP-ChIP_LS174T_Human0.82918124
144TP53_23651856_ChIP-Seq_MEFs_Mouse0.82801697
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82434306
146GBX2_23144817_ChIP-Seq_PC3_Human0.81932836
147AHR_22903824_ChIP-Seq_MCF-7_Human0.79977040
148EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.79872371
149TP63_23658742_ChIP-Seq_EP156T_Human0.78860887
150ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.78794400
151ARNT_22903824_ChIP-Seq_MCF-7_Human0.78732544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology8.67170605
2MP0005257_abnormal_intraocular_pressure7.54664445
3MP0008438_abnormal_cutaneous_collagen6.88562089
4MP0005275_abnormal_skin_tensile6.11951395
5MP0002108_abnormal_muscle_morphology3.43523259
6MP0004145_abnormal_muscle_electrophysio3.28302061
7MP0000751_myopathy3.18863564
8MP0000566_synostosis2.66334355
9MP0006054_spinal_hemorrhage2.60856508
10MP0005508_abnormal_skeleton_morphology2.54202132
11MP0001958_emphysema2.43253649
12MP0003646_muscle_fatigue2.12264480
13MP0005369_muscle_phenotype2.03866418
14MP0002092_abnormal_eye_morphology2.01637705
15MP0000749_muscle_degeneration1.99057057
16MP0004272_abnormal_basement_membrane1.97904076
17MP0003705_abnormal_hypodermis_morpholog1.96697765
18MP0000747_muscle_weakness1.96167407
19MP0003878_abnormal_ear_physiology1.87095055
20MP0005377_hearing/vestibular/ear_phenot1.87095055
21MP0000733_abnormal_muscle_development1.78310742
22MP0002106_abnormal_muscle_physiology1.75912048
23MP0009250_abnormal_appendicular_skeleto1.75027719
24MP0009053_abnormal_anal_canal1.72133109
25* MP0005193_abnormal_anterior_eye1.66364712
26MP0000759_abnormal_skeletal_muscle1.61470769
27MP0002060_abnormal_skin_morphology1.59506656
28MP0000750_abnormal_muscle_regeneration1.55482867
29MP0003279_aneurysm1.51279790
30MP0003385_abnormal_body_wall1.47728641
31MP0004133_heterotaxia1.47116494
32MP0004087_abnormal_muscle_fiber1.43572123
33* MP0005197_abnormal_uvea_morphology1.43530402
34MP0002933_joint_inflammation1.37440707
35MP0005390_skeleton_phenotype1.36375778
36MP0004885_abnormal_endolymph1.30338435
37MP0000579_abnormal_nail_morphology1.28802615
38MP0001661_extended_life_span1.25564755
39MP0009384_cardiac_valve_regurgitation1.23318914
40MP0002115_abnormal_skeleton_extremities1.21579778
41MP0002697_abnormal_eye_size1.21168876
42MP0005076_abnormal_cell_differentiation1.16353758
43MP0004036_abnormal_muscle_relaxation1.16184836
44MP0000163_abnormal_cartilage_morphology1.14921253
45MP0003011_delayed_dark_adaptation1.13559339
46MP0002932_abnormal_joint_morphology1.13529573
47MP0005391_vision/eye_phenotype1.10610150
48MP0002249_abnormal_larynx_morphology1.03794481
49MP0002896_abnormal_bone_mineralization0.98923036
50MP0002295_abnormal_pulmonary_circulatio0.95592829
51MP0001542_abnormal_bone_strength0.95403733
52MP0000534_abnormal_ureter_morphology0.95165244
53MP0010030_abnormal_orbit_morphology0.93684132
54MP0001299_abnormal_eye_distance/0.93126994
55MP0002269_muscular_atrophy0.90790647
56MP0002109_abnormal_limb_morphology0.90575981
57MP0003115_abnormal_respiratory_system0.89759278
58MP0005620_abnormal_muscle_contractility0.89547203
59MP0005023_abnormal_wound_healing0.88251737
60MP0000767_abnormal_smooth_muscle0.86972112
61MP0002113_abnormal_skeleton_development0.84437574
62MP0003937_abnormal_limbs/digits/tail_de0.84380778
63MP0000372_irregular_coat_pigmentation0.84115063
64MP0003755_abnormal_palate_morphology0.83741893
65MP0002282_abnormal_trachea_morphology0.83083055
66MP0000428_abnormal_craniofacial_morphol0.82640315
67MP0001243_abnormal_dermal_layer0.82195661
68MP0004134_abnormal_chest_morphology0.81168637
69MP0004233_abnormal_muscle_weight0.80789212
70MP0000470_abnormal_stomach_morphology0.80716525
71MP0003724_increased_susceptibility_to0.80709898
72MP0005248_abnormal_Harderian_gland0.80373263
73MP0003091_abnormal_cell_migration0.79414214
74MP0002089_abnormal_postnatal_growth/wei0.79352053
75MP0002006_tumorigenesis0.76208215
76MP0000537_abnormal_urethra_morphology0.76070451
77MP0000343_altered_response_to0.75517729
78MP0003303_peritoneal_inflammation0.75149736
79MP0005187_abnormal_penis_morphology0.73849952
80MP0003045_fibrosis0.73573130
81MP0002837_dystrophic_cardiac_calcinosis0.73245830
82MP0000013_abnormal_adipose_tissue0.73237872
83MP0003137_abnormal_impulse_conducting0.71877146
84MP0003942_abnormal_urinary_system0.70911544
85MP0004130_abnormal_muscle_cell0.69801401
86MP0005623_abnormal_meninges_morphology0.68720646
87MP0001963_abnormal_hearing_physiology0.68411438
88MP0001533_abnormal_skeleton_physiology0.68049675
89MP0000049_abnormal_middle_ear0.67773545
90MP0003122_maternal_imprinting0.67527880
91MP0002090_abnormal_vision0.64981620
92MP0002114_abnormal_axial_skeleton0.64814337
93MP0003828_pulmonary_edema0.64625260
94MP0001286_abnormal_eye_development0.64418838
95MP0000026_abnormal_inner_ear0.64120287
96MP0002166_altered_tumor_susceptibility0.63026709
97MP0009278_abnormal_bone_marrow0.62334851
98MP0004484_altered_response_of0.60413581
99MP0002135_abnormal_kidney_morphology0.59399826
100MP0002233_abnormal_nose_morphology0.58133730
101MP0002116_abnormal_craniofacial_bone0.57723085
102MP0000762_abnormal_tongue_morphology0.57058587
103MP0003123_paternal_imprinting0.56114138
104MP0002133_abnormal_respiratory_system0.54761905
105MP0005388_respiratory_system_phenotype0.54761905
106MP0004147_increased_porphyrin_level0.54608991
107MP0000538_abnormal_urinary_bladder0.54371251
108MP0003941_abnormal_skin_development0.52993553
109MP0003283_abnormal_digestive_organ0.52229796
110MP0005171_absent_coat_pigmentation0.49893500
111MP0000631_abnormal_neuroendocrine_gland0.49859811
112MP0003938_abnormal_ear_development0.49377208
113MP0005330_cardiomyopathy0.48884866
114MP0010368_abnormal_lymphatic_system0.48533043
115MP0010630_abnormal_cardiac_muscle0.48528049
116MP0000613_abnormal_salivary_gland0.48498253
117MP0009780_abnormal_chondrocyte_physiolo0.48494975
118MP0000432_abnormal_head_morphology0.47753959
119MP0002128_abnormal_blood_circulation0.47709448
120MP0001175_abnormal_lung_morphology0.46827053
121MP0000462_abnormal_digestive_system0.46530552
122MP0001614_abnormal_blood_vessel0.46024921
123MP0003075_altered_response_to0.45657165
124MP0003935_abnormal_craniofacial_develop0.45618629
125MP0002177_abnormal_outer_ear0.45572965
126MP0003795_abnormal_bone_structure0.44319317
127MP0003567_abnormal_fetal_cardiomyocyte0.44227522
128MP0004510_myositis0.44176690
129MP0001346_abnormal_lacrimal_gland0.44105076
130MP0002998_abnormal_bone_remodeling0.43578820
131MP0000003_abnormal_adipose_tissue0.40088162
132MP0002102_abnormal_ear_morphology0.37950669
133MP0006276_abnormal_autonomic_nervous0.37904871
134MP0004742_abnormal_vestibular_system0.37844088
135MP0002184_abnormal_innervation0.37177775
136MP0010771_integument_phenotype0.37088886

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)7.17155396
2Protrusio acetabuli (HP:0003179)7.06274823
3Increased connective tissue (HP:0009025)5.56180396
4Ankle contracture (HP:0006466)5.36430503
5Muscle fiber inclusion bodies (HP:0100299)4.84962022
6Slender build (HP:0001533)4.78065562
7Muscle fiber splitting (HP:0003555)4.76984291
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.73932160
9Premature rupture of membranes (HP:0001788)4.70969203
10Infantile muscular hypotonia (HP:0008947)4.64162980
11Broad metatarsal (HP:0001783)4.48973288
12Round ear (HP:0100830)4.45698490
13Turricephaly (HP:0000262)4.36184770
14Nemaline bodies (HP:0003798)4.31857497
15Wrist flexion contracture (HP:0001239)4.08971187
16Bowel diverticulosis (HP:0005222)4.03329464
17Soft skin (HP:0000977)4.00659796
18Distal arthrogryposis (HP:0005684)3.98224387
19Nephritis (HP:0000123)3.94744191
20Follicular hyperkeratosis (HP:0007502)3.91955418
21Corneal dystrophy (HP:0001131)3.85614074
22Exercise-induced muscle cramps (HP:0003710)3.85185554
23Shallow orbits (HP:0000586)3.81381175
24Spinal rigidity (HP:0003306)3.78073658
25Anterior segment dysgenesis (HP:0007700)3.77996744
26Exercise-induced myalgia (HP:0003738)3.76598484
27Increased variability in muscle fiber diameter (HP:0003557)3.75862706
28Hypoplasia of the iris (HP:0007676)3.73700747
29Congenital glaucoma (HP:0001087)3.71856837
30Absent phalangeal crease (HP:0006109)3.69387042
31Abnormality of skeletal muscle fiber size (HP:0012084)3.66071774
32Glomerulonephritis (HP:0000099)3.59193987
33Aplasia of the musculature (HP:0100854)3.58240255
34Osteoarthritis (HP:0002758)3.53826651
35Calcaneovalgus deformity (HP:0001848)3.50500070
36Coronal craniosynostosis (HP:0004440)3.43904302
37Deformed tarsal bones (HP:0008119)3.43360830
38Ulnar deviation of the wrist (HP:0003049)3.36776882
39Aortic dissection (HP:0002647)3.35456150
40Exostoses (HP:0100777)3.29196230
41Mildly elevated creatine phosphokinase (HP:0008180)3.29074138
42Abnormality of the parietal bone (HP:0002696)3.27819079
43Hallux valgus (HP:0001822)3.27022015
44Mitral valve prolapse (HP:0001634)3.21628093
45Abnormality of the phalanges of the 2nd finger (HP:0009541)3.10250171
46Partial duplication of the phalanx of hand (HP:0009999)3.06977830
47Myopathic facies (HP:0002058)3.02259393
48Muscle hypertrophy of the lower extremities (HP:0008968)2.99551424
49Abnormal finger flexion creases (HP:0006143)2.99356905
50Bladder diverticulum (HP:0000015)2.97238999
51Striae distensae (HP:0001065)2.96645432
52Cerebral aneurysm (HP:0004944)2.92919456
53Complement deficiency (HP:0004431)2.82903334
54Rectal prolapse (HP:0002035)2.79875727
55Midline defect of the nose (HP:0004122)2.79768593
56Recurrent gram-negative bacterial infections (HP:0005420)2.79186019
57Hypoplastic ischia (HP:0003175)2.77525752
58Dilatation of the ascending aorta (HP:0005111)2.75872771
59Abnormality of the anterior chamber (HP:0000593)2.75735465
60Abnormality of the radial head (HP:0003995)2.74710432
61Abnormality of the peritoneum (HP:0002585)2.69779824
62Cervical subluxation (HP:0003308)2.68138215
63Calf muscle hypertrophy (HP:0008981)2.67431533
64Mesomelia (HP:0003027)2.66358466
65Abnormality of dentin (HP:0010299)2.65303841
66Vertebral compression fractures (HP:0002953)2.65260653
67Trismus (HP:0000211)2.62848257
68Neonatal short-limb short stature (HP:0008921)2.61786255
69Atrophic scars (HP:0001075)2.56872189
70Pterygium (HP:0001059)2.56087265
71Venous insufficiency (HP:0005293)2.55884572
72Symphalangism affecting the phalanges of the hand (HP:0009773)2.52117428
73Limb-girdle muscle weakness (HP:0003325)2.48667737
74Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.46417110
75Corneal erosion (HP:0200020)2.45757470
76Concave nail (HP:0001598)2.45280558
77Biconcave vertebral bodies (HP:0004586)2.44708440
78Fragile skin (HP:0001030)2.44693706
79Ectopia lentis (HP:0001083)2.42867503
80Difficulty running (HP:0009046)2.42277691
81Hyperextensible skin (HP:0000974)2.41213310
82Abnormality of the ischium (HP:0003174)2.40025407
83Joint laxity (HP:0001388)2.37721186
84Abnormality of the 4th metacarpal (HP:0010012)2.37225803
85Tarsal synostosis (HP:0008368)2.36486600
86Peritonitis (HP:0002586)2.36417201
87Shawl scrotum (HP:0000049)2.35554578
88Abnormality of cochlea (HP:0000375)2.34017558
89EMG: myopathic abnormalities (HP:0003458)2.32648021
90Wormian bones (HP:0002645)2.32227022
91Abnormality of the calf musculature (HP:0001430)2.32199358
92Abnormality of the phalanges of the hallux (HP:0010057)2.31875350
93Hip contracture (HP:0003273)2.30530560
94Bell-shaped thorax (HP:0001591)2.28946890
95Buphthalmos (HP:0000557)2.28438217
96Abnormal delivery (HP:0001787)2.24480287
97Genu recurvatum (HP:0002816)2.24092377
98Hypoplasia of the maxilla (HP:0000327)2.23551428
99Thin ribs (HP:0000883)2.21963670
100Abnormality of the calcaneus (HP:0008364)2.20454730
101Hyporeflexia of lower limbs (HP:0002600)2.20343140
102Aortic aneurysm (HP:0004942)2.18424390
103Megalocornea (HP:0000485)2.16499668
104Abnormality of complement system (HP:0005339)2.14727137
105Pulmonary artery stenosis (HP:0004415)2.12932614
106Camptodactyly of toe (HP:0001836)2.11491390
107Short hallux (HP:0010109)2.11359878
108Aplasia/Hypoplasia of the lens (HP:0008063)2.11336740
109Synostosis involving bones of the feet (HP:0009140)2.11020335
110Synostosis involving bones of the lower limbs (HP:0009138)2.11020335
111Muscle stiffness (HP:0003552)2.10196255
112Wide anterior fontanel (HP:0000260)2.09817522
113Myotonia (HP:0002486)2.06662386
114Blue sclerae (HP:0000592)2.05798506
115Mild short stature (HP:0003502)2.03940412
116Microglossia (HP:0000171)2.02347135
117Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.01266399
118Short 4th metacarpal (HP:0010044)2.01266399
119Generalized amyotrophy (HP:0003700)2.00329904
120Limited hip movement (HP:0008800)1.99829090
121Deviation of the hallux (HP:0010051)1.99791427
122Narrow nasal bridge (HP:0000446)1.97179101
123Stage 5 chronic kidney disease (HP:0003774)1.96033626
124Metatarsus adductus (HP:0001840)1.94768826
125Neoplasm of the heart (HP:0100544)1.92879901
126Breech presentation (HP:0001623)1.91947103
127Papilledema (HP:0001085)1.90967494
128Proximal amyotrophy (HP:0007126)1.90637031
129Long toe (HP:0010511)1.90376140
130Inguinal hernia (HP:0000023)1.90110526
131Ulnar deviation of finger (HP:0009465)1.89119961
132Broad hallux (HP:0010055)1.88851467
133Broad toe (HP:0001837)1.88717580
134Ridged nail (HP:0001807)1.88646456
135Elbow flexion contracture (HP:0002987)1.88539238
136Aplasia/Hypoplasia of the hallux (HP:0008362)1.86609886
137Amyloidosis (HP:0011034)1.84982410
138Decreased skull ossification (HP:0004331)1.83798242
139Increased corneal curvature (HP:0100692)1.83637023
140Keratoconus (HP:0000563)1.83637023
141Slender long bone (HP:0003100)1.83555487
142Bulbar palsy (HP:0001283)1.82864812
143Anal stenosis (HP:0002025)1.82639555
144Vascular tortuosity (HP:0004948)1.81614289
145Abnormality of the 2nd finger (HP:0004100)1.81524293
146Aplasia/Hypoplasia involving the musculature (HP:0001460)1.80705139
147Patellar aplasia (HP:0006443)1.79641600
148Abnormality of skull ossification (HP:0002703)1.79357104
149Arterial tortuosity (HP:0005116)1.78811217
150Bronchomalacia (HP:0002780)1.76295710
151Venous abnormality (HP:0002624)1.76262364
152Achilles tendon contracture (HP:0001771)1.76176977
153Premature skin wrinkling (HP:0100678)1.75877226
154Abnormality of the humeroradial joint (HP:0100744)1.75575990
155Long nose (HP:0003189)1.74388827
156Nonprogressive disorder (HP:0003680)1.73636082

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.71367271
2DDR24.40143708
3TTN4.39930280
4LATS14.05628014
5GRK53.79190969
6RIPK13.34167547
7EPHA33.33871635
8CSNK1G13.10683762
9CSNK1G33.05115823
10PDGFRA2.93985486
11PHKG22.82873587
12PHKG12.82873587
13GRK72.80395811
14LATS22.78210895
15TRIB32.65041022
16CSNK1G22.51378093
17MAP3K62.32254119
18AKT22.29096591
19SIK11.82957052
20DMPK1.75654299
21MAP3K71.64825450
22ERN11.62581881
23ERBB41.62004145
24PIK3CG1.60570950
25EPHB11.55506112
26TGFBR21.43345385
27CSK1.38050295
28TSSK61.37477088
29MAP3K31.36914423
30NEK91.35925128
31MAP2K31.35011819
32ARAF1.29180841
33PIK3CA1.27170587
34RPS6KC11.19986010
35RPS6KL11.19986010
36STK31.18743160
37NME11.18157948
38PASK1.17994489
39PDK21.17208955
40ERBB31.14172960
41PDGFRB1.13527221
42EEF2K1.12995846
43PTK61.11920350
44STK38L1.07200451
45RPS6KA61.07074250
46MAP2K21.07064990
47MST1R1.06128288
48PRKCQ1.04594656
49CDK30.96926704
50CAMK2B0.95230660
51FGFR40.93544838
52PKN20.92660984
53MAPKAPK50.89652413
54MUSK0.89501610
55FER0.87786596
56EIF2AK20.87605475
57BMX0.87210137
58MAPK120.84577983
59NLK0.81522430
60KSR20.81118418
61GSK3A0.80764290
62MET0.77920668
63EPHB20.77742413
64CCNB10.77179438
65TAOK10.76104178
66FRK0.75846688
67PRKCH0.75798642
68JAK20.74605793
69KIT0.74539458
70PAK20.73524101
71ITK0.72699390
72SMG10.72253166
73MAPK150.71359286
74TLK10.70775633
75PINK10.68734195
76MAP2K40.68684511
77PRKD30.66067305
78DYRK1B0.65785293
79LRRK20.64828500
80FGFR30.63376241
81SYK0.62608892
82RET0.62177364
83TRPM70.62036362
84NTRK20.59922349
85MAP2K10.58982503
86PRKAA20.58157942
87DYRK1A0.57929817
88STK160.57836028
89FGFR10.55435657
90CDK190.54705513
91MOS0.54385923
92MTOR0.53854662
93ERBB20.53296316
94ADRBK10.53081936
95MKNK10.51723596
96PRKD20.47962454
97ROCK20.47322980
98PDK40.45788321
99PDK30.45788321
100FGFR20.44362395
101CSNK1D0.43489824
102PAK60.43465179
103BRAF0.43370681
104PTK20.41935523
105MAPKAPK30.39411648
106RAF10.38793280
107PRKD10.38356832
108TYRO30.37292313
109PTK2B0.37110750
110STK380.36793099
111INSRR0.35780155
112PAK40.35540036
113ROCK10.33997331
114ILK0.33665480
115PRKCG0.32651589
116MAP3K100.32624480
117INSR0.32406162
118RPS6KA20.32153105
119AURKA0.31949585
120MELK0.31797273
121MAPK110.31708651
122JAK10.31214891
123MAPK70.31081165
124TYK20.30874351
125NEK10.29849884
126NTRK10.29399659
127KSR10.29303347
128TIE10.28728454
129MYLK0.27771779
130ABL10.27626343
131PRKCD0.27502905
132VRK20.27394436
133CDK40.27130455
134BCKDK0.26661910
135PDK10.25431532
136MAPK30.25217778
137PRKCE0.25035566
138MARK20.24645319
139MAPK90.24402140
140PRKAA10.23335160
141CDK80.22888461
142AKT10.22887372
143MAPK40.22768312
144ABL20.22325177
145MAPK10.22172298
146CDK60.21982395
147STK100.21469512
148CHUK0.21362615
149TGFBR10.21330106

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.02426470
2Malaria_Homo sapiens_hsa051443.56519194
3Protein digestion and absorption_Homo sapiens_hsa049743.08610766
4Focal adhesion_Homo sapiens_hsa045102.97520706
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.52339066
6Prion diseases_Homo sapiens_hsa050202.52220301
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.37330287
8Dilated cardiomyopathy_Homo sapiens_hsa054142.26568669
9Amoebiasis_Homo sapiens_hsa051462.05377065
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.01209424
11TGF-beta signaling pathway_Homo sapiens_hsa043501.88352925
12Proteoglycans in cancer_Homo sapiens_hsa052051.56042110
13PI3K-Akt signaling pathway_Homo sapiens_hsa041511.48191946
14Insulin resistance_Homo sapiens_hsa049311.47432443
15Circadian rhythm_Homo sapiens_hsa047101.45146459
16Complement and coagulation cascades_Homo sapiens_hsa046101.45144374
17Basal cell carcinoma_Homo sapiens_hsa052171.38774399
18Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.26287518
19MicroRNAs in cancer_Homo sapiens_hsa052061.24870336
20Hippo signaling pathway_Homo sapiens_hsa043901.22716811
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.21780416
22Small cell lung cancer_Homo sapiens_hsa052221.21619815
23Adherens junction_Homo sapiens_hsa045201.21135358
24Hedgehog signaling pathway_Homo sapiens_hsa043401.16316268
25Phospholipase D signaling pathway_Homo sapiens_hsa040721.13381236
26Adipocytokine signaling pathway_Homo sapiens_hsa049201.11733319
27TNF signaling pathway_Homo sapiens_hsa046681.10428757
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09344260
29Viral myocarditis_Homo sapiens_hsa054161.09236294
30GnRH signaling pathway_Homo sapiens_hsa049121.08830034
31Estrogen signaling pathway_Homo sapiens_hsa049151.04561809
32Toxoplasmosis_Homo sapiens_hsa051451.04093790
33Oxytocin signaling pathway_Homo sapiens_hsa049211.03463774
34Insulin signaling pathway_Homo sapiens_hsa049100.98741259
35Bladder cancer_Homo sapiens_hsa052190.95739873
36Glucagon signaling pathway_Homo sapiens_hsa049220.94720245
37Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94367598
38MAPK signaling pathway_Homo sapiens_hsa040100.94238889
39Wnt signaling pathway_Homo sapiens_hsa043100.91659664
40FoxO signaling pathway_Homo sapiens_hsa040680.90646225
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89595243
42Melanogenesis_Homo sapiens_hsa049160.88978237
43Type II diabetes mellitus_Homo sapiens_hsa049300.87538399
44Osteoclast differentiation_Homo sapiens_hsa043800.84029323
45Legionellosis_Homo sapiens_hsa051340.82591944
46Chronic myeloid leukemia_Homo sapiens_hsa052200.81758523
47Inositol phosphate metabolism_Homo sapiens_hsa005620.81472089
48Tight junction_Homo sapiens_hsa045300.80922422
49Platelet activation_Homo sapiens_hsa046110.80865719
50Starch and sucrose metabolism_Homo sapiens_hsa005000.79966512
51Nitrogen metabolism_Homo sapiens_hsa009100.76278755
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75855632
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75352483
54Melanoma_Homo sapiens_hsa052180.75004509
55Pathways in cancer_Homo sapiens_hsa052000.73408037
56Dorso-ventral axis formation_Homo sapiens_hsa043200.72883098
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72793165
58Pertussis_Homo sapiens_hsa051330.71673203
59Pancreatic cancer_Homo sapiens_hsa052120.71532286
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71508981
61Phagosome_Homo sapiens_hsa041450.70993842
62Prolactin signaling pathway_Homo sapiens_hsa049170.70224827
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.68901984
64Prostate cancer_Homo sapiens_hsa052150.68735060
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66809971
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64384162
67Leishmaniasis_Homo sapiens_hsa051400.63483940
68HTLV-I infection_Homo sapiens_hsa051660.63353580
69Glioma_Homo sapiens_hsa052140.61825958
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.61705361
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.61132186
72Axon guidance_Homo sapiens_hsa043600.59871472
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59709906
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59320046
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59043253
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58797152
77AMPK signaling pathway_Homo sapiens_hsa041520.57744693
78Salivary secretion_Homo sapiens_hsa049700.55762941
79Calcium signaling pathway_Homo sapiens_hsa040200.55624684
80Colorectal cancer_Homo sapiens_hsa052100.54412627
81Renal cell carcinoma_Homo sapiens_hsa052110.54235388
82Hepatitis B_Homo sapiens_hsa051610.53586978
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52743896
84Circadian entrainment_Homo sapiens_hsa047130.52665106
85Ovarian steroidogenesis_Homo sapiens_hsa049130.51036064
86VEGF signaling pathway_Homo sapiens_hsa043700.50858937
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49153934
88Cocaine addiction_Homo sapiens_hsa050300.47867467
89Gastric acid secretion_Homo sapiens_hsa049710.47812874
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47725638
91HIF-1 signaling pathway_Homo sapiens_hsa040660.47534960
92Staphylococcus aureus infection_Homo sapiens_hsa051500.47420400
93Rap1 signaling pathway_Homo sapiens_hsa040150.47403526
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46424972
95Amphetamine addiction_Homo sapiens_hsa050310.46028892
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45486959
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44714332
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44551765
99Tuberculosis_Homo sapiens_hsa051520.43768096
100Salmonella infection_Homo sapiens_hsa051320.43439115
101mTOR signaling pathway_Homo sapiens_hsa041500.42711607
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.42314651
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42066631
104Gap junction_Homo sapiens_hsa045400.42065484
105Renin secretion_Homo sapiens_hsa049240.41898305
106Ras signaling pathway_Homo sapiens_hsa040140.41826353
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40627824
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40385935
109Notch signaling pathway_Homo sapiens_hsa043300.40233635
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40219871
111Endocytosis_Homo sapiens_hsa041440.39794883
112Sulfur relay system_Homo sapiens_hsa041220.39380198
113Long-term depression_Homo sapiens_hsa047300.39206563
114Choline metabolism in cancer_Homo sapiens_hsa052310.38519631
115Lysine degradation_Homo sapiens_hsa003100.38323250
116Renin-angiotensin system_Homo sapiens_hsa046140.38286506
117Bile secretion_Homo sapiens_hsa049760.35466804
118Thyroid hormone synthesis_Homo sapiens_hsa049180.35439473
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34611118
120Other glycan degradation_Homo sapiens_hsa005110.33495806
121Serotonergic synapse_Homo sapiens_hsa047260.33393816
122Insulin secretion_Homo sapiens_hsa049110.33018879
123N-Glycan biosynthesis_Homo sapiens_hsa005100.32174135
124Phototransduction_Homo sapiens_hsa047440.29637110
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29300541
126cAMP signaling pathway_Homo sapiens_hsa040240.29277432
127Non-small cell lung cancer_Homo sapiens_hsa052230.27475214
128Ribosome_Homo sapiens_hsa030100.26371971
129Endometrial cancer_Homo sapiens_hsa052130.21928905
130Glutamatergic synapse_Homo sapiens_hsa047240.17495597
131Cardiac muscle contraction_Homo sapiens_hsa042600.17282870
132Long-term potentiation_Homo sapiens_hsa047200.16190897
133Alcoholism_Homo sapiens_hsa050340.15024399
134Arachidonic acid metabolism_Homo sapiens_hsa005900.13981607
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.11199740
136Pentose phosphate pathway_Homo sapiens_hsa000300.09854254

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