KDR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* vascular endothelial growth factor signaling pathway (GO:0038084)7.43820736
2* lymph vessel development (GO:0001945)7.41067976
3lymphangiogenesis (GO:0001946)7.00644974
4retina vasculature morphogenesis in camera-type eye (GO:0061299)6.19707525
5heart valve formation (GO:0003188)6.10066990
6* cellular response to vascular endothelial growth factor stimulus (GO:0035924)6.03735110
7cell surface receptor signaling pathway involved in heart development (GO:0061311)5.20080092
8regulation of endothelial cell differentiation (GO:0045601)5.00404437
9positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)4.99871080
10patterning of blood vessels (GO:0001569)4.93924595
11morphogenesis of an endothelium (GO:0003159)4.84853182
12endothelial tube morphogenesis (GO:0061154)4.84853182
13blood vessel maturation (GO:0001955)4.80311513
14angiogenesis involved in wound healing (GO:0060055)4.77050960
15sprouting angiogenesis (GO:0002040)4.76131339
16heart trabecula formation (GO:0060347)4.75734941
17ovulation from ovarian follicle (GO:0001542)4.72617545
18* endothelium development (GO:0003158)4.65344889
19endothelial cell morphogenesis (GO:0001886)4.59559159
20Notch receptor processing (GO:0007220)4.55364287
21transcytosis (GO:0045056)4.48697667
22* vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.47461323
23labyrinthine layer development (GO:0060711)4.28500598
24venous blood vessel morphogenesis (GO:0048845)4.27863921
25negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.16424206
26basement membrane organization (GO:0071711)4.02701594
27morphogenesis of an epithelial sheet (GO:0002011)4.01893672
28wound healing, spreading of epidermal cells (GO:0035313)4.01815711
29positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)3.96807986
30positive regulation of lipid kinase activity (GO:0090218)3.91906768
31glomerular filtration (GO:0003094)3.88457624
32negative regulation of blood vessel endothelial cell migration (GO:0043537)3.86719877
33regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.85680272
34aorta morphogenesis (GO:0035909)3.81528598
35regulation of establishment or maintenance of cell polarity (GO:0032878)3.81460172
36coronary vasculature morphogenesis (GO:0060977)3.78459276
37renal filtration (GO:0097205)3.78246671
38atrial cardiac muscle cell action potential (GO:0086014)3.71603672
39monocyte chemotaxis (GO:0002548)3.71045916
40embryonic heart tube development (GO:0035050)3.67312365
41* blood vessel endothelial cell migration (GO:0043534)3.64473594
42negative regulation of endothelial cell migration (GO:0010596)3.60254687
43regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.60186020
44negative regulation of Rho protein signal transduction (GO:0035024)3.57923486
45thrombin receptor signaling pathway (GO:0070493)3.53586848
46* endothelial cell differentiation (GO:0045446)3.50825862
47glomerular visceral epithelial cell development (GO:0072015)3.49581756
48cellular response to hepatocyte growth factor stimulus (GO:0035729)3.48470184
49response to hepatocyte growth factor (GO:0035728)3.48470184
50endothelial cell chemotaxis (GO:0035767)3.46702001
51* positive regulation of vasculogenesis (GO:2001214)3.44833650
52* vasculogenesis (GO:0001570)3.43732881
53neuron projection extension involved in neuron projection guidance (GO:1902284)3.37205792
54axon extension involved in axon guidance (GO:0048846)3.37205792
55cardiac ventricle morphogenesis (GO:0003208)3.36406463
56* regulation of vasculogenesis (GO:2001212)3.33777641
57substrate-dependent cell migration (GO:0006929)3.31138487
58positive regulation of protein kinase C signaling (GO:0090037)3.30049124
59glomerular basement membrane development (GO:0032836)3.29934318
60* cell migration involved in sprouting angiogenesis (GO:0002042)3.23883106
61protein localization to endosome (GO:0036010)3.17978196
62cell migration involved in heart development (GO:0060973)3.17159977
63negative regulation of platelet activation (GO:0010544)3.15437446
64Rap protein signal transduction (GO:0032486)3.12694125
65ventricular trabecula myocardium morphogenesis (GO:0003222)3.09851923
66ganglion development (GO:0061548)3.09190739
67epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.06664880
68trabecula formation (GO:0060343)3.06392175
69negative regulation of epithelial cell migration (GO:0010633)3.05814959
70definitive hemopoiesis (GO:0060216)3.05772770
71establishment of endothelial barrier (GO:0061028)3.05534722
72* surfactant homeostasis (GO:0043129)3.05443913
73glomerular epithelial cell development (GO:0072310)3.05236709
74negative regulation of vascular permeability (GO:0043116)3.04449134
75bundle of His cell to Purkinje myocyte communication (GO:0086069)3.03318609
76cardiac epithelial to mesenchymal transition (GO:0060317)3.02429600
77negative regulation of nitric-oxide synthase activity (GO:0051001)3.02096922
78cardiac chamber morphogenesis (GO:0003206)3.01218849
79Notch signaling involved in heart development (GO:0061314)3.00725127
80blood vessel morphogenesis (GO:0048514)2.99323189
81regulation of vascular permeability (GO:0043114)2.98755835
82neuron remodeling (GO:0016322)2.98266318
83regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.97864451
84endocardial cushion morphogenesis (GO:0003203)2.96979747
85fatty acid transmembrane transport (GO:1902001)2.96515636
86blood vessel remodeling (GO:0001974)2.95634769
87cardiac myofibril assembly (GO:0055003)2.94550310
88positive regulation of endothelial cell differentiation (GO:0045603)2.93088547
89exocrine pancreas development (GO:0031017)2.90381783
90negative regulation of focal adhesion assembly (GO:0051895)2.90062664
91negative regulation of cell junction assembly (GO:1901889)2.90062664
92negative regulation of adherens junction organization (GO:1903392)2.90062664
93plasma membrane repair (GO:0001778)2.88532604
94regulation of establishment of cell polarity (GO:2000114)2.87733191
95dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.87628821
96plasma membrane fusion (GO:0045026)2.87353625
97embryonic foregut morphogenesis (GO:0048617)2.86852554
98* endothelial cell migration (GO:0043542)2.85621968
99negative regulation of cell fate specification (GO:0009996)2.85108975
100negative regulation of keratinocyte proliferation (GO:0010839)2.84314751
101negative regulation of angiogenesis (GO:0016525)2.84081653
102* regulation of endothelial cell migration (GO:0010594)2.83758670
103heart trabecula morphogenesis (GO:0061384)2.81479091
104negative regulation of blood vessel morphogenesis (GO:2000181)2.80218118
105negative regulation of axon extension involved in axon guidance (GO:0048843)2.79804530
106negative regulation of endothelial cell proliferation (GO:0001937)2.78376680
107* regulation of epithelial cell migration (GO:0010632)2.77932486
108endothelial cell proliferation (GO:0001935)2.77434128
109arginine catabolic process (GO:0006527)2.74646084
110trabecula morphogenesis (GO:0061383)2.74096779
111* positive regulation of endothelial cell proliferation (GO:0001938)2.72758574
112regulation of axon extension involved in axon guidance (GO:0048841)2.71498891
113artery development (GO:0060840)2.70401846
114ovulation (GO:0030728)2.67657344
115negative regulation of vasculature development (GO:1901343)2.67466034
116low-density lipoprotein particle clearance (GO:0034383)2.62264069
117cardiac muscle cell proliferation (GO:0060038)2.62120691
118gap junction assembly (GO:0016264)2.61206411
119regulation of blood vessel endothelial cell migration (GO:0043535)2.59948913
120regulation of sarcomere organization (GO:0060297)2.58994308
121protein kinase C signaling (GO:0070528)2.56309753
122* angiogenesis (GO:0001525)2.56102621
123regulation of p38MAPK cascade (GO:1900744)2.55771655
124* regulation of endothelial cell proliferation (GO:0001936)2.55124843
125negative regulation of blood coagulation (GO:0030195)2.53717854
126negative regulation of hemostasis (GO:1900047)2.53717854
127* positive regulation of endothelial cell migration (GO:0010595)2.51998020
128artery morphogenesis (GO:0048844)2.51628244
129positive regulation of smooth muscle cell migration (GO:0014911)2.50147039
130potassium ion import (GO:0010107)2.48681914
131carnitine shuttle (GO:0006853)2.47804065
132regulation of sequestering of triglyceride (GO:0010889)2.46989039
133semaphorin-plexin signaling pathway (GO:0071526)2.46821554
134regulation of axon guidance (GO:1902667)2.44960084
135ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.44258747
136negative regulation of fibrinolysis (GO:0051918)2.43365205

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.45859094
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.75060175
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.51466959
4GATA2_21666600_ChIP-Seq_HMVEC_Human3.24095321
5CLOCK_20551151_ChIP-Seq_293T_Human3.17692676
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.84642274
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.68156587
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.64458873
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.60420818
10SCL_19346495_ChIP-Seq_HPC-7_Human2.38578749
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.30952218
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.28253468
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.25174444
14HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.23550009
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.19061851
16VDR_22108803_ChIP-Seq_LS180_Human2.18410131
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.13721769
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.03564995
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02274772
20* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.96033106
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.92912241
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92401584
23SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.91982620
24TBX20_22080862_ChIP-Seq_HEART_Mouse1.89162889
25TBX20_22328084_ChIP-Seq_HEART_Mouse1.89162889
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.85539275
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85415884
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.83105720
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.79735780
30GATA1_22025678_ChIP-Seq_K562_Human1.78414661
31TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.77280279
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.73842583
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.73584083
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.71259861
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.65515284
36SOX2_18555785_ChIP-Seq_MESCs_Mouse1.63210270
37ZNF263_19887448_ChIP-Seq_K562_Human1.62918493
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.62893980
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59845875
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59383962
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56922152
42MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.55312847
43GATA1_19941826_ChIP-Seq_K562_Human1.55185860
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52388784
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51596414
46* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49145624
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.45385504
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42231541
49* BRD4_25478319_ChIP-Seq_HGPS_Human1.41408643
50* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39391116
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38797884
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.37927763
53CJUN_26792858_Chip-Seq_BT549_Human1.37497745
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.36926775
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.35469582
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33660896
57SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.31911678
58FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31446369
59YAP1_20516196_ChIP-Seq_MESCs_Mouse1.30052707
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28874656
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.28176432
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.28176432
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.28176432
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.26676322
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26268088
66AR_21909140_ChIP-Seq_LNCAP_Human1.26003010
67LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24865484
68RXR_22108803_ChIP-Seq_LS180_Human1.24481809
69TBX3_20139965_ChIP-Seq_ESCs_Mouse1.21009531
70SOX2_20726797_ChIP-Seq_SW620_Human1.20713116
71TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19819368
72FOXA2_19822575_ChIP-Seq_HepG2_Human1.18837509
73CDX2_20551321_ChIP-Seq_CACO-2_Human1.18611411
74AHR_22903824_ChIP-Seq_MCF-7_Human1.17623663
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15885684
76TCF3_18692474_ChIP-Seq_MESCs_Mouse1.15606653
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15550390
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15391145
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14820461
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14375868
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14367080
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12916341
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12342617
84* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12200081
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12132780
86* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11813338
87* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11813338
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11446715
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10804209
90NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10152425
91TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07503589
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.07410640
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07270175
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07270175
95SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06681996
96* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04233935
97GF1_26923725_Chip-Seq_HPCs_Mouse1.03541787
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02975141
99EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01785330
100KDM2B_26808549_Chip-Seq_K562_Human1.01739658
101* ISL1_27105846_Chip-Seq_CPCs_Mouse1.00850725
102EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00022256
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99598984
104NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99400332
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98563440
106KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97722562
107* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96556454
108PIAS1_25552417_ChIP-Seq_VCAP_Human0.96431482
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96306328
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95944250
111NANOG_18692474_ChIP-Seq_MESCs_Mouse0.95854835
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95650114
113SOX17_20123909_ChIP-Seq_XEN_Mouse0.95108115
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94819680
115* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94566483
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93678348
117GATA2_19941826_ChIP-Seq_K562_Human0.93428099
118MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93057214
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.92550865
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.92154721
121ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92090242
122PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91907911
123WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91576941
124* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91499813
125* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91055935
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.90726352
127FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90399330
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90309880
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89834664
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89215068
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88586684
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88208169
133NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88108001
134CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87393998
135CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87392122
136SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86903970
137SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85559131
138SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85559131
139JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85528934
140BCAT_22108803_ChIP-Seq_LS180_Human0.85201786
141SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83930035
142DROSHA_22980978_ChIP-Seq_HELA_Human0.83590825

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system8.16043599
2* MP0001879_abnormal_lymphatic_vessel5.58978980
3MP0005167_abnormal_blood-brain_barrier4.82459941
4MP0004084_abnormal_cardiac_muscle3.73541276
5* MP0004272_abnormal_basement_membrane3.55777671
6MP0003828_pulmonary_edema3.16622647
7MP0003724_increased_susceptibility_to3.10707469
8MP0000537_abnormal_urethra_morphology3.06308792
9MP0006054_spinal_hemorrhage2.75001724
10MP0004215_abnormal_myocardial_fiber2.63695385
11MP0006138_congestive_heart_failure2.50099304
12MP0000013_abnormal_adipose_tissue2.40152580
13MP0004036_abnormal_muscle_relaxation2.38116243
14MP0009053_abnormal_anal_canal1.94447796
15MP0008775_abnormal_heart_ventricle1.94371713
16MP0005360_urolithiasis1.93387828
17MP0004484_altered_response_of1.86936149
18MP0000767_abnormal_smooth_muscle1.86592958
19MP0005330_cardiomyopathy1.85358355
20MP0002138_abnormal_hepatobiliary_system1.81055760
21MP0003279_aneurysm1.74008880
22MP0003705_abnormal_hypodermis_morpholog1.73022457
23MP0002332_abnormal_exercise_endurance1.69899430
24MP0002127_abnormal_cardiovascular_syste1.68977840
25MP0003300_gastrointestinal_ulcer1.67309142
26MP0004130_abnormal_muscle_cell1.65132620
27MP0002972_abnormal_cardiac_muscle1.61293547
28MP0002837_dystrophic_cardiac_calcinosis1.60158055
29* MP0001544_abnormal_cardiovascular_syste1.58899595
30* MP0005385_cardiovascular_system_phenoty1.58899595
31MP0005085_abnormal_gallbladder_physiolo1.57078527
32MP0005670_abnormal_white_adipose1.52178374
33MP0000751_myopathy1.51716492
34MP0005595_abnormal_vascular_smooth1.50152333
35MP0004147_increased_porphyrin_level1.49586793
36* MP0010630_abnormal_cardiac_muscle1.49426704
37MP0001849_ear_inflammation1.48570988
38* MP0005165_increased_susceptibility_to1.48033217
39MP0002128_abnormal_blood_circulation1.47017797
40MP0004085_abnormal_heartbeat1.45750425
41MP0005623_abnormal_meninges_morphology1.42273796
42MP0000516_abnormal_urinary_system1.40718117
43MP0005367_renal/urinary_system_phenotyp1.40718117
44MP0000249_abnormal_blood_vessel1.37781350
45MP0010234_abnormal_vibrissa_follicle1.35716434
46MP0005620_abnormal_muscle_contractility1.35657952
47MP0003191_abnormal_cellular_cholesterol1.32018233
48MP0009278_abnormal_bone_marrow1.31442205
49MP0005365_abnormal_bile_salt1.31262247
50* MP0002925_abnormal_cardiovascular_devel1.29379053
51MP0002877_abnormal_melanocyte_morpholog1.28645888
52MP0003315_abnormal_perineum_morphology1.24146862
53MP0002139_abnormal_hepatobiliary_system1.22447779
54MP0003566_abnormal_cell_adhesion1.22367923
55MP0008004_abnormal_stomach_pH1.21049323
56MP0002295_abnormal_pulmonary_circulatio1.20140826
57* MP0001614_abnormal_blood_vessel1.18572000
58MP0000343_altered_response_to1.18202731
59MP0009697_abnormal_copulation1.13600723
60MP0000230_abnormal_systemic_arterial1.13206495
61MP0003303_peritoneal_inflammation1.11161896
62MP0003252_abnormal_bile_duct1.10755663
63* MP0005380_embryogenesis_phenotype1.09110317
64* MP0001672_abnormal_embryogenesis/_devel1.09110317
65MP0004087_abnormal_muscle_fiber1.08138027
66MP0002697_abnormal_eye_size1.06397092
67MP0010329_abnormal_lipoprotein_level1.05378117
68MP0000003_abnormal_adipose_tissue1.05286013
69MP0001730_embryonic_growth_arrest1.04840582
70MP0001915_intracranial_hemorrhage1.04737653
71* MP0000266_abnormal_heart_morphology1.02914650
72MP0010030_abnormal_orbit_morphology1.02304641
73MP0004885_abnormal_endolymph1.00906988
74MP0003941_abnormal_skin_development0.98792444
75MP0005084_abnormal_gallbladder_morpholo0.97740584
76MP0005409_darkened_coat_color0.96066152
77MP0003935_abnormal_craniofacial_develop0.93361465
78MP0003119_abnormal_digestive_system0.93212408
79MP0000750_abnormal_muscle_regeneration0.92296136
80* MP0002084_abnormal_developmental_patter0.91925502
81MP0008875_abnormal_xenobiotic_pharmacok0.90009400
82MP0005164_abnormal_response_to0.88980078
83MP0001784_abnormal_fluid_regulation0.87136388
84MP0010352_gastrointestinal_tract_polyps0.86939729
85MP0001958_emphysema0.86646014
86MP0000749_muscle_degeneration0.84895914
87MP0005375_adipose_tissue_phenotype0.84747572
88MP0004883_abnormal_blood_vessel0.84004022
89MP0005666_abnormal_adipose_tissue0.83512435
90MP0004510_myositis0.82890221
91MP0003091_abnormal_cell_migration0.82812518
92MP0009379_abnormal_foot_pigmentation0.80598336
93MP0003950_abnormal_plasma_membrane0.79274062
94MP0008438_abnormal_cutaneous_collagen0.78986487
95MP0005197_abnormal_uvea_morphology0.78136334
96MP0004782_abnormal_surfactant_physiolog0.77209605
97MP0005187_abnormal_penis_morphology0.75232667
98* MP0005193_abnormal_anterior_eye0.73832851
99MP0009643_abnormal_urine_homeostasis0.73461576
100MP0001851_eye_inflammation0.69637634
101MP0000465_gastrointestinal_hemorrhage0.69610233
102MP0009780_abnormal_chondrocyte_physiolo0.69371078
103* MP0003943_abnormal_hepatobiliary_system0.66930531
104MP0003122_maternal_imprinting0.66274628
105MP0005319_abnormal_enzyme/_coenzyme0.65924528
106MP0001756_abnormal_urination0.65629401
107MP0002133_abnormal_respiratory_system0.63073457
108MP0005388_respiratory_system_phenotype0.63073457
109MP0000609_abnormal_liver_physiology0.62722357
110MP0002088_abnormal_embryonic_growth/wei0.61827132
111MP0003137_abnormal_impulse_conducting0.61718867
112MP0002092_abnormal_eye_morphology0.59999160
113MP0003984_embryonic_growth_retardation0.59529506
114MP0002118_abnormal_lipid_homeostasis0.59217659
115MP0002933_joint_inflammation0.58875499
116MP0002896_abnormal_bone_mineralization0.58340415
117MP0004185_abnormal_adipocyte_glucose0.58270693
118* MP0002080_prenatal_lethality0.57723857
119MP0003567_abnormal_fetal_cardiomyocyte0.57293367
120MP0002106_abnormal_muscle_physiology0.56682963
121* MP0002086_abnormal_extraembryonic_tissu0.56645230
122MP0005332_abnormal_amino_acid0.56337310
123* MP0002085_abnormal_embryonic_tissue0.54790218
124MP0005248_abnormal_Harderian_gland0.51841539
125MP0009672_abnormal_birth_weight0.51503508
126MP0002108_abnormal_muscle_morphology0.50889787
127MP0005083_abnormal_biliary_tract0.50237526
128MP0005369_muscle_phenotype0.49871449
129MP0005058_abnormal_lysosome_morphology0.49240095
130MP0003385_abnormal_body_wall0.45149185
131MP0003937_abnormal_limbs/digits/tail_de0.44640518
132* MP0001697_abnormal_embryo_size0.43823503
133MP0000733_abnormal_muscle_development0.43057691
134MP0005501_abnormal_skin_physiology0.42915255
135MP0004808_abnormal_hematopoietic_stem0.40766482
136MP0001191_abnormal_skin_condition0.39929808
137MP0002254_reproductive_system_inflammat0.39176585
138MP0000428_abnormal_craniofacial_morphol0.38353220

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)6.25720184
2Esophageal varix (HP:0002040)5.41322036
3Hematochezia (HP:0002573)5.37885796
4Nonimmune hydrops fetalis (HP:0001790)5.24592146
5Spontaneous hematomas (HP:0007420)5.17820821
6Deep venous thrombosis (HP:0002625)4.44318391
7Lymphangioma (HP:0100764)4.43393810
8Ventricular tachycardia (HP:0004756)4.02909147
9Hypoglycemic coma (HP:0001325)3.90115523
10Muscle fiber splitting (HP:0003555)3.88555184
11Cerebral hemorrhage (HP:0001342)3.87717317
12Sudden death (HP:0001699)3.70184553
13Scotoma (HP:0000575)3.62258938
14Limb dystonia (HP:0002451)3.60690943
15Broad metatarsal (HP:0001783)3.59466939
16Arterial tortuosity (HP:0005116)3.48608717
17Conjunctival telangiectasia (HP:0000524)3.44802979
18Visceral angiomatosis (HP:0100761)3.43550862
19Adactyly (HP:0009776)3.43198387
20Myotonia (HP:0002486)3.34541013
21Cerebral aneurysm (HP:0004944)3.33445735
22Portal hypertension (HP:0001409)3.29420508
23Hemangiomatosis (HP:0007461)3.28005145
24Premature rupture of membranes (HP:0001788)3.27319411
25Hemorrhage of the eye (HP:0011885)3.25772076
26Hypopigmentation of the fundus (HP:0007894)3.25282767
27Atrial fibrillation (HP:0005110)3.24668677
28Hyporeflexia of lower limbs (HP:0002600)3.24598992
29Amblyopia (HP:0000646)3.23349932
30Increased connective tissue (HP:0009025)3.23148283
31Areflexia of lower limbs (HP:0002522)3.18564104
32Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.16898661
33Short 4th metacarpal (HP:0010044)3.16898661
34Absent hand (HP:0004050)3.15161211
35Abnormality of the nasal mucosa (HP:0000433)3.10628600
36Supraventricular arrhythmia (HP:0005115)3.07101595
37Vascular tortuosity (HP:0004948)3.00812749
38Long clavicles (HP:0000890)2.99307639
39Primary atrial arrhythmia (HP:0001692)2.95949947
40Abnormality of the vasculature of the conjunctiva (HP:0008054)2.95526267
41Abnormality of the hepatic vasculature (HP:0006707)2.92354258
42Hyperinsulinemic hypoglycemia (HP:0000825)2.90988022
43Exotropia (HP:0000577)2.90610517
44Difficulty running (HP:0009046)2.89108650
45Cavernous hemangioma (HP:0001048)2.87002257
46Right ventricular cardiomyopathy (HP:0011663)2.86804350
47Skull defect (HP:0001362)2.82750130
48Pigmentary retinal degeneration (HP:0001146)2.82424565
49Porencephaly (HP:0002132)2.80039348
50Exercise-induced muscle cramps (HP:0003710)2.79056312
51Supraventricular tachycardia (HP:0004755)2.77820664
52Joint hemorrhage (HP:0005261)2.76666914
53Hypoglycemic seizures (HP:0002173)2.74011156
54Mesangial abnormality (HP:0001966)2.73577966
55Myocardial infarction (HP:0001658)2.72350459
56Protrusio acetabuli (HP:0003179)2.71226044
57Lipoatrophy (HP:0100578)2.68997799
58Thin ribs (HP:0000883)2.68318498
59Pancreatic islet-cell hyperplasia (HP:0004510)2.67575048
60* Capillary hemangiomas (HP:0005306)2.66577306
61Abnormality of the intrinsic pathway (HP:0010989)2.63292789
62Venous insufficiency (HP:0005293)2.60446755
63Aneurysm (HP:0002617)2.60196514
64Short hallux (HP:0010109)2.56166838
65Spastic diplegia (HP:0001264)2.53643309
66Subacute progressive viral hepatitis (HP:0006572)2.52466303
67Hypoalphalipoproteinemia (HP:0003233)2.47520399
68Intrahepatic cholestasis (HP:0001406)2.44427011
69Short palpebral fissure (HP:0012745)2.42478902
70Congenital, generalized hypertrichosis (HP:0004540)2.41683042
71Shallow orbits (HP:0000586)2.41572671
72Stroke (HP:0001297)2.41145090
73Syncope (HP:0001279)2.40799788
74Aplasia cutis congenita (HP:0001057)2.38958365
75Wrist flexion contracture (HP:0001239)2.38499446
76Ketoacidosis (HP:0001993)2.38365907
77Venous abnormality (HP:0002624)2.37591328
78Hemiparesis (HP:0001269)2.36288055
79Cutaneous syndactyly (HP:0012725)2.35702920
80Atrioventricular block (HP:0001678)2.33983981
81Hypoplastic ischia (HP:0003175)2.33922493
82Aplasia/Hypoplasia of the hallux (HP:0008362)2.32714827
83Overgrowth (HP:0001548)2.32701502
84Mucosal telangiectasiae (HP:0100579)2.30649409
85Abnormality of the ischium (HP:0003174)2.30097420
86Cutaneous finger syndactyly (HP:0010554)2.29066694
87Lymphedema (HP:0001004)2.24871439
88High pitched voice (HP:0001620)2.21899801
89Bilateral sensorineural hearing impairment (HP:0008619)2.17183797
90Dilated cardiomyopathy (HP:0001644)2.14024427
91Aortic aneurysm (HP:0004942)2.13663251
92Impaired pain sensation (HP:0007328)2.12208426
93Abnormality of pain sensation (HP:0010832)2.12208426
94Hypoplasia of the iris (HP:0007676)2.12129338
95Hyperlipoproteinemia (HP:0010980)2.12119988
96Increased variability in muscle fiber diameter (HP:0003557)2.12104148
97Prolonged partial thromboplastin time (HP:0003645)2.11971748
98Absent eyebrow (HP:0002223)2.11569549
99Myoglobinuria (HP:0002913)2.11298632
100Congenital cataract (HP:0000519)2.10971398
101Xanthomatosis (HP:0000991)2.09347839
102Abnormality of the 4th metacarpal (HP:0010012)2.09246455
103Vitreoretinal degeneration (HP:0000655)2.08201400
104Dysautonomia (HP:0002459)2.06678620
105Pulmonary embolism (HP:0002204)2.05986927
106Focal segmental glomerulosclerosis (HP:0000097)2.05334789
107Cardiovascular calcification (HP:0011915)2.03851209
108Ketosis (HP:0001946)2.03365327
109Vertebral clefting (HP:0008428)2.03020509
110Chondrocalcinosis (HP:0000934)2.02500843
111Short tibia (HP:0005736)2.01958675
112Growth hormone excess (HP:0000845)2.01918627
113Absent toe (HP:0010760)2.01350928
114Prolonged QT interval (HP:0001657)2.00992997
115Anteriorly placed anus (HP:0001545)2.00537938
116Abnormality of the vitreous humor (HP:0004327)1.99090708
117Pulmonary hypertension (HP:0002092)1.98743093
118Absent eyelashes (HP:0000561)1.97057729
119Neonatal death (HP:0003811)1.96748357
120Disproportionate tall stature (HP:0001519)1.95983690
121Calf muscle hypertrophy (HP:0008981)1.95866069
122Anterior segment dysgenesis (HP:0007700)1.95529997
123Vascular calcification (HP:0004934)1.95271433
124Joint contractures involving the joints of the feet (HP:0100492)1.95210366
125Flexion contracture of toe (HP:0005830)1.95210366
126Pulmonary artery stenosis (HP:0004415)1.95199058
127EMG: myopathic abnormalities (HP:0003458)1.95108782
128Abnormality of the common coagulation pathway (HP:0010990)1.94234507
129Complement deficiency (HP:0004431)1.93627986
130Generalized hypotonia (HP:0001290)1.93410382
131Tetraparesis (HP:0002273)1.92978949
132Abnormality of the pancreatic islet cells (HP:0006476)1.91579908
133Abnormality of endocrine pancreas physiology (HP:0012093)1.91579908
134Spinal rigidity (HP:0003306)1.90701013
135Cortical dysplasia (HP:0002539)1.90595889
136Heart block (HP:0012722)1.90570044
137Abnormal vertebral ossification (HP:0100569)1.90215875
138Exercise-induced myalgia (HP:0003738)1.89476546
139Hemiplegia (HP:0002301)1.88255170
140Thrombophlebitis (HP:0004418)1.88166898
141Camptodactyly of toe (HP:0001836)1.87821644
142Aortic dissection (HP:0002647)1.87588934
143Abnormality of Sharpey fibers (HP:0100685)1.86479358
144Delayed CNS myelination (HP:0002188)1.85636405
145Abnormality of skeletal muscle fiber size (HP:0012084)1.85249196
146Hyperammonemia (HP:0001987)1.84624145
147Difficulty climbing stairs (HP:0003551)1.84275165
148Large for gestational age (HP:0001520)1.82515167
149Bicuspid aortic valve (HP:0001647)1.81669346
150Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.79759574
151Broad ribs (HP:0000885)1.79273504
152Centrally nucleated skeletal muscle fibers (HP:0003687)1.77434578
153Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77300435
154Abnormal atrioventricular conduction (HP:0005150)1.76381783
155Asymmetry of the thorax (HP:0001555)1.74708409
156Hydroureter (HP:0000072)1.72612790
157Aplasia involving bones of the upper limbs (HP:0009823)1.72567094
158Aplasia of the phalanges of the hand (HP:0009802)1.72567094
159Aplasia involving bones of the extremities (HP:0009825)1.72567094
160Aplasia/Hypoplasia of the tibia (HP:0005772)1.72413647

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* KDR5.70618928
2TGFBR23.92008553
3TGFBR12.87105039
4GRK12.11235556
5EPHB22.07269110
6RIPK12.00850312
7TIE111.7438407
8INSRR1.98895801
9PTK2B1.82484587
10NTRK11.56122191
11ERN11.56068433
12MYLK1.46277002
13PTK61.29467925
14TTN1.29171791
15PDK21.28111617
16PKN21.19569521
17PDGFRA1.16143824
18WNK41.12628834
19FER1.10363297
20FGFR41.06169796
21TRIB31.04911622
22DMPK1.04116789
23EPHB11.00349418
24MAPK120.99492882
25PRKG20.98831693
26MAP2K30.95126480
27EEF2K0.93767778
28SIK10.91041180
29PRKD10.85236883
30BCKDK0.79685587
31TYRO30.78891339
32PRKAA20.76790945
33FGFR20.75168426
34OBSCN0.75125149
35MAPK150.74141559
36CAMK1D0.70442485
37SCYL20.69407612
38CAMK1G0.68843336
39YES10.66991226
40PAK40.66245279
41PTK20.65714365
42LATS20.64626832
43PRKCH0.64617770
44LATS10.63493822
45STK390.62927180
46AKT30.62381248
47JAK10.61813834
48MAP3K30.61319889
49FGFR30.61019121
50LMTK20.60802688
51TSSK60.59460336
52MAPK70.57330281
53LRRK20.57308338
54TEC0.56750594
55CAMK40.55996759
56CSK0.55647762
57MAP2K20.54688272
58GSK3A0.53130771
59PHKG10.51672282
60PHKG20.51672282
61MET0.49548974
62CSNK1G10.49052382
63ROCK20.48935167
64ARAF0.48044680
65MOS0.46933228
66TRPM70.46838870
67JAK20.46305100
68PDGFRB0.45449735
69PRKD30.43764046
70RET0.43346568
71ZAP700.42455363
72MAP3K10.41974158
73PDK40.41231771
74PDK30.41231771
75BCR0.39975178
76MAP2K10.39762551
77NEK90.39420043
78CDK60.39257509
79MAP3K130.38631340
80PRKAA10.37418066
81PLK20.37097588
82PDPK10.36360058
83MAP3K70.36229662
84ERBB40.35439776
85NLK0.35303936
86* IGF1R0.35284306
87MARK30.34929832
88MAP3K90.33921118
89PRKCE0.33823989
90PLK40.33785122
91ROCK10.33667468
92JAK30.32915734
93PIK3CA0.32206635
94TYK20.31526449
95ITK0.30869499
96* SRC0.30739178
97CDK90.30229124
98STK100.29879114
99INSR0.29398491
100RPS6KA20.27922094
101TAF10.27559038
102MAP3K100.27259796
103MARK20.26742830
104PAK20.26328001
105PAK30.26303011
106BMPR1B0.25481979
107FRK0.24723371
108PRKD20.23919230
109MAPK100.22077359
110FGFR10.21331408
111MKNK20.21027598
112CSNK1A1L0.20549770
113NUAK10.20202549
114FLT30.18675381
115EPHA30.18583523
116TBK10.18531256
117TNIK0.18411929
118MTOR0.18338216
119PLK30.17926848
120CSNK1G30.17882090
121SGK20.17791908
122GRK50.17705015
123* EGFR0.17670591
124AKT20.17530632
125SGK30.17028924
126PRKACB0.16431428
127MAPK40.16130747
128KIT0.15878405
129PRKACG0.15656704
130MAP3K80.14662204
131MAP3K110.14577017
132FES0.14373324
133BMX0.14095286
134MAPKAPK30.14044491
135HCK0.12595266
136KSR20.11872551
137FGR0.10965248
138WEE10.10477202
139CSNK1G20.10065107
140MAPK90.08890199
141SMG10.08705901
142MAP3K120.07998328
143MKNK10.07717077
144SGK2230.07307831
145SGK4940.07307831
146MAP3K60.06826866

Predicted pathways (KEGG)

RankGene SetZ-score
1Arginine biosynthesis_Homo sapiens_hsa002202.53962033
2Fatty acid degradation_Homo sapiens_hsa000712.46179214
3Complement and coagulation cascades_Homo sapiens_hsa046102.41960269
4Nitrogen metabolism_Homo sapiens_hsa009102.34445474
5PPAR signaling pathway_Homo sapiens_hsa033202.10653486
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.07380025
7Adherens junction_Homo sapiens_hsa045202.05875392
8ECM-receptor interaction_Homo sapiens_hsa045122.03145329
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.02307449
10Propanoate metabolism_Homo sapiens_hsa006402.01334719
11Bile secretion_Homo sapiens_hsa049761.94977672
12Dilated cardiomyopathy_Homo sapiens_hsa054141.88823360
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.88681177
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.86424659
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.84517405
16* Focal adhesion_Homo sapiens_hsa045101.79834331
17Fatty acid metabolism_Homo sapiens_hsa012121.78751485
18Steroid biosynthesis_Homo sapiens_hsa001001.64060732
19Tryptophan metabolism_Homo sapiens_hsa003801.63373725
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.63228032
21Thyroid cancer_Homo sapiens_hsa052161.63187088
22Dorso-ventral axis formation_Homo sapiens_hsa043201.61279975
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59014251
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.52953062
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52780601
26Prion diseases_Homo sapiens_hsa050201.47182499
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46888420
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.39849708
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37094979
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32273821
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.30673423
32ABC transporters_Homo sapiens_hsa020101.26341066
33MicroRNAs in cancer_Homo sapiens_hsa052061.26189608
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26143765
35Insulin resistance_Homo sapiens_hsa049311.25855772
36Caffeine metabolism_Homo sapiens_hsa002321.21717551
37Notch signaling pathway_Homo sapiens_hsa043301.18742704
38* Rap1 signaling pathway_Homo sapiens_hsa040151.17882268
39Butanoate metabolism_Homo sapiens_hsa006501.13964497
40Small cell lung cancer_Homo sapiens_hsa052221.11764914
41Pancreatic cancer_Homo sapiens_hsa052121.11306810
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10868558
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08689566
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08593096
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05994025
46* Endocytosis_Homo sapiens_hsa041441.03841403
47Amoebiasis_Homo sapiens_hsa051461.03546192
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03328847
49Chronic myeloid leukemia_Homo sapiens_hsa052201.02168420
50Staphylococcus aureus infection_Homo sapiens_hsa051501.01886022
51Adipocytokine signaling pathway_Homo sapiens_hsa049201.01647136
52Ovarian steroidogenesis_Homo sapiens_hsa049130.97565396
53Fat digestion and absorption_Homo sapiens_hsa049750.96153937
54Protein digestion and absorption_Homo sapiens_hsa049740.96121440
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95773696
56beta-Alanine metabolism_Homo sapiens_hsa004100.95747720
57HIF-1 signaling pathway_Homo sapiens_hsa040660.92322912
58Peroxisome_Homo sapiens_hsa041460.91852005
59Hippo signaling pathway_Homo sapiens_hsa043900.91709470
60Tight junction_Homo sapiens_hsa045300.90135076
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89097772
62* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.88827115
63Lysine degradation_Homo sapiens_hsa003100.87635626
64African trypanosomiasis_Homo sapiens_hsa051430.87051877
65Malaria_Homo sapiens_hsa051440.86576212
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85506412
67Prostate cancer_Homo sapiens_hsa052150.85229566
68Platelet activation_Homo sapiens_hsa046110.84672706
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.84672660
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82809321
71Viral myocarditis_Homo sapiens_hsa054160.82629375
72Colorectal cancer_Homo sapiens_hsa052100.81302776
73Fatty acid elongation_Homo sapiens_hsa000620.80782986
74Shigellosis_Homo sapiens_hsa051310.80738526
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80681112
76Axon guidance_Homo sapiens_hsa043600.79462981
77Renal cell carcinoma_Homo sapiens_hsa052110.78251990
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77588261
79Renin-angiotensin system_Homo sapiens_hsa046140.75173166
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74835853
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73931819
82Basal cell carcinoma_Homo sapiens_hsa052170.73884806
83Starch and sucrose metabolism_Homo sapiens_hsa005000.73781223
84Renin secretion_Homo sapiens_hsa049240.72919865
85* Proteoglycans in cancer_Homo sapiens_hsa052050.72243825
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72069335
87Endometrial cancer_Homo sapiens_hsa052130.71821274
88Vitamin digestion and absorption_Homo sapiens_hsa049770.71331811
89Bladder cancer_Homo sapiens_hsa052190.69734544
90Pyruvate metabolism_Homo sapiens_hsa006200.68383753
91Melanogenesis_Homo sapiens_hsa049160.68123905
92Phenylalanine metabolism_Homo sapiens_hsa003600.67375846
93Carbon metabolism_Homo sapiens_hsa012000.66604126
94Arginine and proline metabolism_Homo sapiens_hsa003300.65231487
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64985129
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.64796377
97Glioma_Homo sapiens_hsa052140.64629827
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63994165
99* VEGF signaling pathway_Homo sapiens_hsa043700.61250803
100Toxoplasmosis_Homo sapiens_hsa051450.59726153
101* Ras signaling pathway_Homo sapiens_hsa040140.58418653
102AMPK signaling pathway_Homo sapiens_hsa041520.57467748
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56999080
104Inositol phosphate metabolism_Homo sapiens_hsa005620.56215191
105Fatty acid biosynthesis_Homo sapiens_hsa000610.55410607
106Pathways in cancer_Homo sapiens_hsa052000.55007226
107Glucagon signaling pathway_Homo sapiens_hsa049220.54802024
108Cardiac muscle contraction_Homo sapiens_hsa042600.53550715
109Salmonella infection_Homo sapiens_hsa051320.52478351
110Melanoma_Homo sapiens_hsa052180.52217970
111Histidine metabolism_Homo sapiens_hsa003400.50184852
112Wnt signaling pathway_Homo sapiens_hsa043100.49328256
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.48988893
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48537862
115Choline metabolism in cancer_Homo sapiens_hsa052310.48430787
116Tyrosine metabolism_Homo sapiens_hsa003500.48375772
117TGF-beta signaling pathway_Homo sapiens_hsa043500.46841842
118Glycerolipid metabolism_Homo sapiens_hsa005610.46541568
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45779181
120Rheumatoid arthritis_Homo sapiens_hsa053230.45294894
121Retinol metabolism_Homo sapiens_hsa008300.45242795
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44884060
123cAMP signaling pathway_Homo sapiens_hsa040240.43924913
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43833901
125Gap junction_Homo sapiens_hsa045400.43790197
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43278606
127Chemical carcinogenesis_Homo sapiens_hsa052040.43267132
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42541306
129Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42141387
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39952345
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.39781422
132Estrogen signaling pathway_Homo sapiens_hsa049150.39307703
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38670929
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36906277
135Gastric acid secretion_Homo sapiens_hsa049710.36251814
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.35813327
137Pancreatic secretion_Homo sapiens_hsa049720.35734858
138Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35228847
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.35017357
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.34906667
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31589350
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30389422
143Insulin signaling pathway_Homo sapiens_hsa049100.28230418
144GnRH signaling pathway_Homo sapiens_hsa049120.25284463
145MAPK signaling pathway_Homo sapiens_hsa040100.25250242
146Vibrio cholerae infection_Homo sapiens_hsa051100.24610605
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23963819
148Selenocompound metabolism_Homo sapiens_hsa004500.23177607
149* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21358453
150FoxO signaling pathway_Homo sapiens_hsa040680.19176732
151Other glycan degradation_Homo sapiens_hsa005110.19125853
152Sphingolipid metabolism_Homo sapiens_hsa006000.17626861
153ErbB signaling pathway_Homo sapiens_hsa040120.16772944

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