KDM6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.05355970
2negative regulation of cell killing (GO:0031342)5.05355970
3endothelial cell chemotaxis (GO:0035767)4.84367972
4regulation of interleukin-12 biosynthetic process (GO:0045075)4.80221819
5response to peptidoglycan (GO:0032494)4.66204163
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.46863722
7positive thymic T cell selection (GO:0045059)4.43782741
8macrophage activation involved in immune response (GO:0002281)4.35360382
9regulation of gamma-delta T cell differentiation (GO:0045586)4.20652466
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.14012011
11regulation of gamma-delta T cell activation (GO:0046643)4.12350945
12detection of other organism (GO:0098543)4.05732201
13cellular extravasation (GO:0045123)3.98864122
14neutrophil activation involved in immune response (GO:0002283)3.90401039
15detection of molecule of bacterial origin (GO:0032490)3.90074610
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.89977403
17antigen processing and presentation of endogenous antigen (GO:0019883)3.85473825
18positive T cell selection (GO:0043368)3.79865776
19detection of bacterium (GO:0016045)3.79816695
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.77626245
21positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.70105995
22response to muramyl dipeptide (GO:0032495)3.63459934
23detection of external biotic stimulus (GO:0098581)3.61894794
24regulation of interferon-beta biosynthetic process (GO:0045357)3.61140749
25neutrophil activation (GO:0042119)3.53651626
26regulation of B cell receptor signaling pathway (GO:0050855)3.50929952
27cellular response to nicotine (GO:0071316)3.48592115
28regulation of T-helper 2 cell differentiation (GO:0045628)3.48516493
29regulation of vitamin D biosynthetic process (GO:0060556)3.47968484
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.46461993
31lipopolysaccharide-mediated signaling pathway (GO:0031663)3.43106121
32thymic T cell selection (GO:0045061)3.42177520
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.41382056
34granulocyte activation (GO:0036230)3.40067438
35neutrophil mediated immunity (GO:0002446)3.34661000
36detection of biotic stimulus (GO:0009595)3.32429018
37tolerance induction (GO:0002507)3.29447047
38response to interleukin-15 (GO:0070672)3.28350141
39NIK/NF-kappaB signaling (GO:0038061)3.27734481
40modulation by symbiont of host cellular process (GO:0044068)3.25870825
41leukocyte aggregation (GO:0070486)3.24899643
42modulation by virus of host process (GO:0019054)3.23272576
43defense response to protozoan (GO:0042832)3.22492389
44endoderm formation (GO:0001706)3.21312382
45positive regulation of gamma-delta T cell activation (GO:0046645)3.20466916
46response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.20254180
47response to host immune response (GO:0052572)3.20254180
48CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.19121729
49macrophage activation (GO:0042116)3.17859968
50regulation of interleukin-2 biosynthetic process (GO:0045076)3.12327734
51immunoglobulin mediated immune response (GO:0016064)3.11084225
52regulation of vitamin metabolic process (GO:0030656)3.09055053
53negative regulation of cytokine production involved in immune response (GO:0002719)3.08223475
54regulation of cell proliferation involved in kidney development (GO:1901722)3.07745504
55activated T cell proliferation (GO:0050798)3.06918956
56response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.05607709
57response to host (GO:0075136)3.05607709
58response to host defenses (GO:0052200)3.05607709
59histone H3-K4 trimethylation (GO:0080182)3.04763838
60negative regulation of leukocyte mediated immunity (GO:0002704)3.04606787
61negative regulation of T cell mediated immunity (GO:0002710)3.03952369
62T cell selection (GO:0045058)3.02118070
63response to type I interferon (GO:0034340)3.01922124
64cellular response to type I interferon (GO:0071357)3.01788787
65type I interferon signaling pathway (GO:0060337)3.01788787
66interferon-gamma production (GO:0032609)3.01486219
67negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.01097699
68response to protozoan (GO:0001562)2.99621492
69regulation of mast cell degranulation (GO:0043304)2.98171226
70negative regulation of toll-like receptor signaling pathway (GO:0034122)2.96762553
71negative regulation of interleukin-6 production (GO:0032715)2.95328970
72respiratory burst (GO:0045730)2.95094476
73myeloid cell activation involved in immune response (GO:0002275)2.94730066
74T-helper 1 type immune response (GO:0042088)2.92870370
75leukocyte migration involved in inflammatory response (GO:0002523)2.90969048
76regulation of interleukin-13 production (GO:0032656)2.88658028
77cell migration involved in sprouting angiogenesis (GO:0002042)2.87265702
78regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87097670
79positive regulation of interleukin-2 production (GO:0032743)2.85531793
80regulation of fever generation (GO:0031620)2.84326724
81myeloid leukocyte mediated immunity (GO:0002444)2.84096894
82regulation of immunoglobulin secretion (GO:0051023)2.83820807
83negative regulation of erythrocyte differentiation (GO:0045647)2.82695961
84cellular response to interleukin-15 (GO:0071350)2.81807023
85microglial cell activation (GO:0001774)2.81114523
86regulation of tolerance induction (GO:0002643)2.80420160
87myeloid dendritic cell differentiation (GO:0043011)2.80406007
88positive regulation of heat generation (GO:0031652)2.79203532
89negative regulation of type 2 immune response (GO:0002829)2.79032743
90positive regulation of interleukin-17 production (GO:0032740)2.78411554
91negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.76872934
92negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.75602453
93negative regulation of T-helper cell differentiation (GO:0045623)2.75602453
94negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.74707586
95negative regulation of translation, ncRNA-mediated (GO:0040033)2.74707586
96regulation of translation, ncRNA-mediated (GO:0045974)2.74707586
97T-helper cell differentiation (GO:0042093)2.74698737
98CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.74698737
99negative thymic T cell selection (GO:0045060)2.71622610
100negative T cell selection (GO:0043383)2.71449253
101production of molecular mediator involved in inflammatory response (GO:0002532)2.70978610
102regulation of mast cell activation involved in immune response (GO:0033006)2.70371668
103regulation of leukocyte degranulation (GO:0043300)2.69967464
104facial nerve structural organization (GO:0021612)2.67984762
105positive regulation of astrocyte differentiation (GO:0048711)2.67047181
106regulation of toll-like receptor signaling pathway (GO:0034121)2.66465084
107regulation of myeloid leukocyte mediated immunity (GO:0002886)2.65943100
108interferon-gamma-mediated signaling pathway (GO:0060333)2.64853470
109negative regulation of interleukin-12 production (GO:0032695)2.64773813
110skeletal muscle cell differentiation (GO:0035914)2.64120355
111ear development (GO:0043583)2.64069636
112neutrophil chemotaxis (GO:0030593)2.64007149
113positive regulation of type 2 immune response (GO:0002830)2.63119238
114response to laminar fluid shear stress (GO:0034616)2.62304692
115regulation of regulatory T cell differentiation (GO:0045589)2.62157457
116negative regulation of alpha-beta T cell activation (GO:0046636)2.60888252
117tyrosine phosphorylation of STAT protein (GO:0007260)2.59484749
118regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.59358721
119regulation of p38MAPK cascade (GO:1900744)2.58437102
120positive regulation of tolerance induction (GO:0002645)2.58376169
121neutrophil migration (GO:1990266)2.56715090
122regulation of type 2 immune response (GO:0002828)2.56474982
123B cell receptor signaling pathway (GO:0050853)2.54837104
124negative regulation of innate immune response (GO:0045824)2.53192293
125alpha-beta T cell differentiation (GO:0046632)2.53133754
126T cell receptor signaling pathway (GO:0050852)2.52507353
127negative regulation of production of molecular mediator of immune response (GO:0002701)2.51445739
128myeloid leukocyte activation (GO:0002274)2.50902498
129positive regulation of interleukin-4 production (GO:0032753)2.50733135
130alpha-beta T cell differentiation involved in immune response (GO:0002293)2.50705000
131alpha-beta T cell activation involved in immune response (GO:0002287)2.50705000
132T cell differentiation involved in immune response (GO:0002292)2.50705000
133regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.50117897
134positive regulation of isotype switching (GO:0045830)2.49742185
135myeloid dendritic cell activation (GO:0001773)2.48915961
136regulation of mast cell activation (GO:0033003)2.48551468
137regulation of isotype switching to IgG isotypes (GO:0048302)2.43102916
138cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.40426540
139regulation of interleukin-2 production (GO:0032663)2.39871584
140radial glial cell differentiation (GO:0060019)2.39406277
141positive regulation of metanephros development (GO:0072216)2.38448809
142JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.35922468
143germinal center formation (GO:0002467)2.33004413
144positive regulation of DNA recombination (GO:0045911)2.29996405
145T cell differentiation (GO:0030217)2.28715423
146regulation of T cell tolerance induction (GO:0002664)2.28531540
147alpha-beta T cell activation (GO:0046631)2.27247641
148Notch signaling involved in heart development (GO:0061314)2.26971644
149regulation of chronic inflammatory response (GO:0002676)2.26584009
150regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.25178719
151positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.25178719
152regulation of heat generation (GO:0031650)2.25175150
153regulation of thymocyte apoptotic process (GO:0070243)2.24932264
154positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.24310528
155regulation of interleukin-4 production (GO:0032673)2.23184525
156modulation by symbiont of host defense response (GO:0052031)2.22735844
157modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.22735844
158modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.22735844
159positive regulation by organism of defense response of other organism involved in symbiotic interact2.22735844
160modulation by symbiont of host immune response (GO:0052553)2.22735844
161positive regulation by symbiont of host defense response (GO:0052509)2.22735844
162face development (GO:0060324)2.21272890
163trophoblast giant cell differentiation (GO:0060707)2.21216397
164negative regulation of T cell differentiation in thymus (GO:0033085)2.19984194
165positive regulation of B cell mediated immunity (GO:0002714)2.19873270
166positive regulation of immunoglobulin mediated immune response (GO:0002891)2.19873270
167cellular response to gonadotropin stimulus (GO:0071371)2.18700680
168germ cell migration (GO:0008354)2.17324599
169monocyte chemotaxis (GO:0002548)2.16744300
170histone H3-K4 methylation (GO:0051568)2.16660114
171negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.15848447
172regulation of monocyte differentiation (GO:0045655)2.15019339
173negative regulation of myoblast differentiation (GO:0045662)2.13376412
174positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.12778868
175regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.12778868
176regulation of interleukin-12 production (GO:0032655)2.12285563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.85150271
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.38613315
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.24059515
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.09847682
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.45736081
6NOTCH1_21737748_ChIP-Seq_TLL_Human3.01816800
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.93619171
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.85337268
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.84199557
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.71434770
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.67383370
12RUNX_20019798_ChIP-Seq_JUKART_Human2.55594752
13* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.51382812
14* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.45251673
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.33203204
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.28390769
17* MYC_22102868_ChIP-Seq_BL_Human2.28073105
18* TCF7_22412390_ChIP-Seq_EML_Mouse2.20004799
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.19309073
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.19309073
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.19309073
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.17752013
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.08173880
24* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.07066748
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04892362
26SCL_19346495_ChIP-Seq_HPC-7_Human2.04372920
27* SPI1_23127762_ChIP-Seq_K562_Human2.02422211
28* KDM2B_26808549_Chip-Seq_DND41_Human2.01238426
29* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.92354826
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.91483789
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91482832
32* KDM2B_26808549_Chip-Seq_JURKAT_Human1.88307224
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82688787
34LXR_22292898_ChIP-Seq_THP-1_Human1.78759392
35VDR_21846776_ChIP-Seq_THP-1_Human1.78681866
36* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78302958
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77104238
38* MAF_26560356_Chip-Seq_TH1_Human1.74480944
39VDR_24763502_ChIP-Seq_THP-1_Human1.72477506
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.72313595
41* UTX_26944678_Chip-Seq_JUKART_Human1.65101378
42* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64764756
43* STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63608438
44KDM2B_26808549_Chip-Seq_K562_Human1.63005291
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62112837
46SPI1_23547873_ChIP-Seq_NB4_Human1.60132386
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57695705
48* ELK3_25401928_ChIP-Seq_HUVEC_Human1.57041760
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55687849
50CDX2_20551321_ChIP-Seq_CACO-2_Human1.55383536
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52810195
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.50083598
53* MYB_26560356_Chip-Seq_TH2_Human1.49758666
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49196887
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48176558
56VDR_24787735_ChIP-Seq_THP-1_Human1.47846805
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.44959361
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.44825796
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42193790
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41472476
61* RING1B_27294783_Chip-Seq_NPCs_Mouse1.39882075
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.39009076
63* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32887597
64* RACK7_27058665_Chip-Seq_MCF-7_Human1.31504220
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31118107
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.30929562
67* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28877530
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27462855
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27133731
70* MAF_26560356_Chip-Seq_TH2_Human1.26140646
71GATA1_19941826_ChIP-Seq_K562_Human1.26061633
72* MYB_26560356_Chip-Seq_TH1_Human1.24730479
73* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23124113
74* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21917115
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18322741
76SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17442277
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17046393
78* GATA3_27048872_Chip-Seq_THYMUS_Human1.15797206
79* RUNX1_27514584_Chip-Seq_MCF-7_Human1.13639086
80* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13548963
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12475123
82CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11690477
83* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11648087
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10960626
85MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10682224
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10142685
87UBF1/2_26484160_Chip-Seq_HMECs_Human1.09739059
88EZH2_27304074_Chip-Seq_ESCs_Mouse1.09362817
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08472314
90PU_27001747_Chip-Seq_BMDM_Mouse1.08400129
91RNF2_27304074_Chip-Seq_ESCs_Mouse1.08193175
92* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07670984
93* ISL1_27105846_Chip-Seq_CPCs_Mouse1.06616915
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06483516
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04510645
96* NCOR1_26117541_ChIP-Seq_K562_Human1.04187066
97* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03886457
98SA1_27219007_Chip-Seq_ERYTHROID_Human1.03878048
99GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02563091
100JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01459080
101MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00611781
102EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00439337
103NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00023775
104* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99507227
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99249069
106TP53_20018659_ChIP-ChIP_R1E_Mouse0.98538714
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97902453
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97609990
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97609990
110PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97306161
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97139534
112AHR_22903824_ChIP-Seq_MCF-7_Human0.96450727
113IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96400708
114NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96292945
115* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95547331
116* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94921921
117BCOR_27268052_Chip-Seq_Bcells_Human0.94913462
118SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94645150
119EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94477245
120RNF2_18974828_ChIP-Seq_MESCs_Mouse0.94477245
121ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94404656
122* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94226636
123SMAD_19615063_ChIP-ChIP_OVARY_Human0.94100342
124CLOCK_20551151_ChIP-Seq_293T_Human0.93308502
125IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92706683
126GATA2_19941826_ChIP-Seq_K562_Human0.92126334
127RNF2_27304074_Chip-Seq_NSC_Mouse0.91895774
128GATA2_21666600_ChIP-Seq_HMVEC_Human0.91845892
129* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91773666
130* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91763923
131* IRF8_27001747_Chip-Seq_BMDM_Mouse0.91513661
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91492059
133* CREB1_26743006_Chip-Seq_LNCaP_Human0.91065588
134* RUNX1_22412390_ChIP-Seq_EML_Mouse0.90973634
135BCL6_27268052_Chip-Seq_Bcells_Human0.90932611
136DROSHA_22980978_ChIP-Seq_HELA_Human0.90166412
137RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89825727
138FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89600959
139FOXO3_23340844_ChIP-Seq_DLD1_Human0.89347338
140SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89296354
141ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88246864
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88110013
143CJUN_26792858_Chip-Seq_BT549_Human0.87961911
144SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86928241
145* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84972065
146* KLF5_25053715_ChIP-Seq_YYC3_Human0.84006146
147PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83142522
148CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82417326
149RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81531142
150EZH2_27294783_Chip-Seq_ESCs_Mouse0.81157917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.54654619
2MP0003763_abnormal_thymus_physiology3.24774717
3MP0004510_myositis3.10462455
4MP0003724_increased_susceptibility_to2.65531621
5MP0003436_decreased_susceptibility_to2.46919630
6MP0009278_abnormal_bone_marrow2.42304173
7MP0004381_abnormal_hair_follicle2.40777156
8MP0003300_gastrointestinal_ulcer2.24052349
9MP0002405_respiratory_system_inflammati2.22369179
10MP0000685_abnormal_immune_system2.17473302
11MP0005387_immune_system_phenotype2.16523783
12MP0001790_abnormal_immune_system2.16523783
13MP0006082_CNS_inflammation2.15126397
14MP0005000_abnormal_immune_tolerance2.02377566
15MP0005451_abnormal_body_composition2.02121794
16MP0001851_eye_inflammation1.92429270
17MP0002277_abnormal_respiratory_mucosa1.87129663
18MP0001853_heart_inflammation1.83405203
19MP0003172_abnormal_lysosome_physiology1.82362064
20MP0001800_abnormal_humoral_immune1.82298266
21MP0003866_abnormal_defecation1.81042865
22MP0008260_abnormal_autophagy1.76638389
23MP0002933_joint_inflammation1.75300351
24MP0005076_abnormal_cell_differentiation1.73485365
25MP0005671_abnormal_response_to1.73276261
26MP0008995_early_reproductive_senescence1.70236554
27MP0008961_abnormal_basal_metabolism1.69383561
28MP0003191_abnormal_cellular_cholesterol1.67038800
29MP0008004_abnormal_stomach_pH1.66073709
30MP0002723_abnormal_immune_serum1.65976483
31MP0009333_abnormal_splenocyte_physiolog1.64406683
32MP0009764_decreased_sensitivity_to1.63520372
33MP0004742_abnormal_vestibular_system1.63178541
34MP0002452_abnormal_antigen_presenting1.57204885
35MP0003828_pulmonary_edema1.55726921
36MP0000703_abnormal_thymus_morphology1.50634714
37* MP0002420_abnormal_adaptive_immunity1.45190075
38MP0000465_gastrointestinal_hemorrhage1.43489779
39* MP0001819_abnormal_immune_cell1.43171007
40MP0005310_abnormal_salivary_gland1.42333747
41MP0005464_abnormal_platelet_physiology1.42026308
42MP0010155_abnormal_intestine_physiology1.39067716
43MP0002132_abnormal_respiratory_system1.38904740
44MP0002148_abnormal_hypersensitivity_rea1.37729522
45MP0002166_altered_tumor_susceptibility1.35163429
46MP0002138_abnormal_hepatobiliary_system1.35030387
47MP0004808_abnormal_hematopoietic_stem1.33781092
48MP0002398_abnormal_bone_marrow1.32628694
49MP0000049_abnormal_middle_ear1.32324070
50MP0008469_abnormal_protein_level1.32039828
51MP0004947_skin_inflammation1.30674284
52MP0002998_abnormal_bone_remodeling1.30483811
53MP0002009_preneoplasia1.30142665
54MP0003075_altered_response_to1.29376986
55MP0000858_altered_metastatic_potential1.24291429
56MP0009840_abnormal_foam_cell1.23968021
57MP0001835_abnormal_antigen_presentation1.23130216
58MP0005423_abnormal_somatic_nervous1.23109530
59MP0003453_abnormal_keratinocyte_physiol1.20818075
60MP0001533_abnormal_skeleton_physiology1.20733319
61MP0005390_skeleton_phenotype1.20508297
62MP0002419_abnormal_innate_immunity1.19471087
63MP0000716_abnormal_immune_system1.18131603
64MP0005257_abnormal_intraocular_pressure1.17347286
65MP0009785_altered_susceptibility_to1.16879258
66MP0000383_abnormal_hair_follicle1.16463076
67MP0005058_abnormal_lysosome_morphology1.15814511
68MP0005409_darkened_coat_color1.14696689
69* MP0005025_abnormal_response_to1.13991327
70MP0002006_tumorigenesis1.10523977
71MP0005166_decreased_susceptibility_to1.09035718
72MP0005167_abnormal_blood-brain_barrier1.06665690
73MP0004858_abnormal_nervous_system1.06240288
74MP0003385_abnormal_body_wall1.05475782
75MP0001340_abnormal_eyelid_morphology1.05092669
76MP0002722_abnormal_immune_system1.04233714
77MP0003448_altered_tumor_morphology1.03836414
78MP0005164_abnormal_response_to1.02686125
79MP0010030_abnormal_orbit_morphology1.01331996
80MP0005508_abnormal_skeleton_morphology1.01242285
81MP0001879_abnormal_lymphatic_vessel1.01165967
82MP0004883_abnormal_blood_vessel1.00348191
83MP0000689_abnormal_spleen_morphology0.99147287
84MP0002249_abnormal_larynx_morphology0.98198766
85MP0003705_abnormal_hypodermis_morpholog0.96931000
86MP0003136_yellow_coat_color0.96552040
87MP0002332_abnormal_exercise_endurance0.95656286
88MP0000767_abnormal_smooth_muscle0.95481707
89MP0003938_abnormal_ear_development0.95298375
90MP0003656_abnormal_erythrocyte_physiolo0.94439615
91MP0001663_abnormal_digestive_system0.94412366
92MP0000604_amyloidosis0.93251305
93MP0001348_abnormal_lacrimal_gland0.92967802
94MP0003183_abnormal_peptide_metabolism0.92806062
95MP0001873_stomach_inflammation0.92193146
96MP0003941_abnormal_skin_development0.91981681
97MP0000566_synostosis0.91853222
98MP0001545_abnormal_hematopoietic_system0.90523529
99MP0005397_hematopoietic_system_phenotyp0.90523529
100MP0003690_abnormal_glial_cell0.90268846
101MP0003091_abnormal_cell_migration0.90089845
102MP0000733_abnormal_muscle_development0.89061439
103MP0002396_abnormal_hematopoietic_system0.86048456
104MP0002098_abnormal_vibrissa_morphology0.85911584
105MP0002116_abnormal_craniofacial_bone0.85794017
106MP0002429_abnormal_blood_cell0.85270844
107MP0003795_abnormal_bone_structure0.84285655
108MP0002925_abnormal_cardiovascular_devel0.81923308
109MP0001845_abnormal_inflammatory_respons0.81763699
110MP0002653_abnormal_ependyma_morphology0.81633164
111MP0005174_abnormal_tail_pigmentation0.81444791
112MP0001216_abnormal_epidermal_layer0.81158096
113MP0000432_abnormal_head_morphology0.79936176
114MP0003755_abnormal_palate_morphology0.79754582
115MP0009250_abnormal_appendicular_skeleto0.77595619
116MP0002751_abnormal_autonomic_nervous0.77449432
117MP0001243_abnormal_dermal_layer0.77230758
118MP0002254_reproductive_system_inflammat0.76289733
119MP0008789_abnormal_olfactory_epithelium0.76084685
120MP0009379_abnormal_foot_pigmentation0.75762029
121MP0002282_abnormal_trachea_morphology0.75121987
122MP0000249_abnormal_blood_vessel0.74886578
123MP0005075_abnormal_melanosome_morpholog0.74750156
124MP0003045_fibrosis0.74624575
125MP0008057_abnormal_DNA_replication0.74518570
126MP0002697_abnormal_eye_size0.74250503
127MP0000343_altered_response_to0.73669918
128MP0005248_abnormal_Harderian_gland0.73412216
129MP0003935_abnormal_craniofacial_develop0.72864412
130MP0000613_abnormal_salivary_gland0.71816740
131MP0002060_abnormal_skin_morphology0.71355317
132MP0009765_abnormal_xenobiotic_induced0.71159551
133MP0001286_abnormal_eye_development0.69970590
134MP0009763_increased_sensitivity_to0.67937991
135MP0003221_abnormal_cardiomyocyte_apopto0.66613339
136MP0005535_abnormal_body_temperature0.61031771
137MP0005666_abnormal_adipose_tissue0.60877441
138MP0004130_abnormal_muscle_cell0.60298589
139MP0005381_digestive/alimentary_phenotyp0.57860334

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.08795556
2Recurrent bacterial skin infections (HP:0005406)4.69270774
3Abnormality of macrophages (HP:0004311)4.65305541
4Recurrent gram-negative bacterial infections (HP:0005420)3.91195822
5Elevated erythrocyte sedimentation rate (HP:0003565)3.89802053
6Increased density of long bones (HP:0006392)3.78789678
7Persistence of primary teeth (HP:0006335)3.78008185
8Eczematoid dermatitis (HP:0000976)3.27523881
9Abnormality of the fingertips (HP:0001211)3.26081245
10Keratoconjunctivitis (HP:0001096)3.21442647
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.15171997
12Abnormality of the nasal septum (HP:0000419)2.98247949
13Recurrent skin infections (HP:0001581)2.95020943
14Encephalitis (HP:0002383)2.93168855
15Severe combined immunodeficiency (HP:0004430)2.89577605
16Urticaria (HP:0001025)2.84709061
17Cellulitis (HP:0100658)2.83434617
18Episodic fever (HP:0001954)2.83211552
19Lip pit (HP:0100267)2.83192163
20Amyloidosis (HP:0011034)2.79017295
21Mediastinal lymphadenopathy (HP:0100721)2.68350057
22Prolonged bleeding time (HP:0003010)2.65635997
23Optic neuritis (HP:0100653)2.65402583
24Retrobulbar optic neuritis (HP:0100654)2.65402583
25Depressed nasal tip (HP:0000437)2.65156334
26Upper limb muscle weakness (HP:0003484)2.63531999
27Increased IgM level (HP:0003496)2.61456853
28Orchitis (HP:0100796)2.58679903
29Aplasia cutis congenita (HP:0001057)2.57824458
30Pulmonary artery stenosis (HP:0004415)2.55054561
31Ulnar claw (HP:0001178)2.47556498
32Leukocytosis (HP:0001974)2.46224867
33Peripheral hypomyelination (HP:0007182)2.45407050
34Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.43880304
35Recurrent fungal infections (HP:0002841)2.36124147
36Myositis (HP:0100614)2.35252896
37Parakeratosis (HP:0001036)2.34638404
38Anhidrosis (HP:0000970)2.34202230
39Hypochromic anemia (HP:0001931)2.33852128
40Recurrent viral infections (HP:0004429)2.32761267
41Supernumerary ribs (HP:0005815)2.31625111
42Pulmonary embolism (HP:0002204)2.29835385
43Sparse lateral eyebrow (HP:0005338)2.29297609
44Gangrene (HP:0100758)2.28551321
45Inflammation of the large intestine (HP:0002037)2.27149882
46Gastrointestinal inflammation (HP:0004386)2.26927953
47Combined immunodeficiency (HP:0005387)2.25659434
48Interstitial pulmonary disease (HP:0006530)2.24292560
49Segmental peripheral demyelination/remyelination (HP:0003481)2.23060184
50Autoimmune thrombocytopenia (HP:0001973)2.21035945
51Hypochromic microcytic anemia (HP:0004840)2.20319301
52Abnormality of the pleura (HP:0002103)2.17475205
53Anorexia (HP:0002039)2.15099073
54Epistaxis (HP:0000421)2.14306045
55Gingival bleeding (HP:0000225)2.13367378
56Submucous cleft hard palate (HP:0000176)2.11384618
57Abnormality of eosinophils (HP:0001879)2.10703121
58Gastrointestinal stroma tumor (HP:0100723)2.10562876
59Oligodontia (HP:0000677)2.08665165
60Hypergammaglobulinemia (HP:0010702)2.08582611
61Slow saccadic eye movements (HP:0000514)2.07167875
62Supernumerary bones of the axial skeleton (HP:0009144)2.06861302
63Sepsis (HP:0100806)2.06780867
64Eosinophilia (HP:0001880)2.06533879
65Thick nail (HP:0001805)2.06432244
66Somatic mutation (HP:0001428)2.06029949
67Abnormality of the endocardium (HP:0004306)2.03496205
68Panhypogammaglobulinemia (HP:0003139)2.02845490
69Loss of speech (HP:0002371)2.02700910
70Rib fusion (HP:0000902)2.02080475
71Midline defect of the nose (HP:0004122)2.01976738
72Restrictive lung disease (HP:0002091)2.01770972
73Osteomyelitis (HP:0002754)2.01521226
74Increased cerebral lipofuscin (HP:0011813)2.01159634
75Acne (HP:0001061)2.00828803
76Intestinal fistula (HP:0100819)2.00683769
77Lymphopenia (HP:0001888)2.00166538
78Onion bulb formation (HP:0003383)1.97809156
79Colitis (HP:0002583)1.96753532
80Chin dimple (HP:0010751)1.94409351
81Gastrointestinal infarctions (HP:0005244)1.92353662
82Pulmonary infiltrates (HP:0002113)1.91839064
83T lymphocytopenia (HP:0005403)1.89883416
84Vasculitis (HP:0002633)1.89763195
85Obstructive lung disease (HP:0006536)1.88530550
86Chronic obstructive pulmonary disease (HP:0006510)1.88530550
87Abnormality of the intervertebral disk (HP:0005108)1.87755594
88Glomerulopathy (HP:0100820)1.87517883
89Emphysema (HP:0002097)1.86532261
90Abnormality of cells of the lymphoid lineage (HP:0012140)1.85859026
91Vertigo (HP:0002321)1.84647568
92Abnormality of T cells (HP:0002843)1.84365825
93Syringomyelia (HP:0003396)1.83866007
94Spinal cord lesions (HP:0100561)1.83866007
95Increased serum ferritin (HP:0003281)1.83832187
96Abnormality of the peritoneum (HP:0002585)1.82671857
97Abnormality of T cell number (HP:0011839)1.81238112
98Disproportionate tall stature (HP:0001519)1.81131813
99Abnormality of the pericardium (HP:0001697)1.80798536
100Stomach cancer (HP:0012126)1.80268240
101Subacute progressive viral hepatitis (HP:0006572)1.78525860
102Nasal polyposis (HP:0100582)1.78418190
103Gingivitis (HP:0000230)1.78290649
104Spontaneous hematomas (HP:0007420)1.78278923
105Hemoptysis (HP:0002105)1.77578159
106Anal stenosis (HP:0002025)1.76427024
107Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75854493
108Broad face (HP:0000283)1.75610704
109Increased CSF protein (HP:0002922)1.75589358
110Neoplasm of the tracheobronchial system (HP:0100552)1.75425802
111Long eyelashes (HP:0000527)1.74177783
112Trigonocephaly (HP:0000243)1.72920711
113Thin bony cortex (HP:0002753)1.72830890
114Joint swelling (HP:0001386)1.72619336
115Alveolar cell carcinoma (HP:0006519)1.71468999
116Arthralgia (HP:0002829)1.71269657
117Abnormality of liposaccharide metabolism (HP:0010968)1.71204296
118Abnormality of glycosphingolipid metabolism (HP:0004343)1.71204296
119Abnormality of glycolipid metabolism (HP:0010969)1.71204296
120Preauricular pit (HP:0004467)1.69744581
121Periauricular skin pits (HP:0100277)1.69744581
122Keratitis (HP:0000491)1.69498137
123Malnutrition (HP:0004395)1.69012689
124Hypoplasia of the iris (HP:0007676)1.68679269
125Ureteral obstruction (HP:0006000)1.68575196
126Cheilitis (HP:0100825)1.68242832
127Obstructive sleep apnea (HP:0002870)1.67950674
128Abnormality of the columella (HP:0009929)1.67167306
129Recurrent cutaneous fungal infections (HP:0011370)1.66463868
130Chronic mucocutaneous candidiasis (HP:0002728)1.66463868
131Ureteral stenosis (HP:0000071)1.64361721
132Concave nail (HP:0001598)1.64219313
133Absent hand (HP:0004050)1.61506337
134Abnormality of primary teeth (HP:0006481)1.60614486
135Abnormality of the parietal bone (HP:0002696)1.59161551
136Thyroiditis (HP:0100646)1.58777057
137Dislocated radial head (HP:0003083)1.57867031
138Abnormality of the radial head (HP:0003995)1.56223326
139Down-sloping shoulders (HP:0200021)1.55143310
140Morphological abnormality of the middle ear (HP:0008609)1.55100992
141Granulocytopenia (HP:0001913)1.54584227
142Increased IgE level (HP:0003212)1.53747751
143Recurrent abscess formation (HP:0002722)1.53692571
144Long palpebral fissure (HP:0000637)1.53520446
145Premature loss of primary teeth (HP:0006323)1.51926903
146Pustule (HP:0200039)1.50705699
147IgA deficiency (HP:0002720)1.49908292
148Meningitis (HP:0001287)1.49597638
149Keratoconjunctivitis sicca (HP:0001097)1.46691295
150Progressive sensorineural hearing impairment (HP:0000408)1.45744984
151Septate vagina (HP:0001153)1.44549934
152Chest pain (HP:0100749)1.44199151
153Premature skin wrinkling (HP:0100678)1.43996190
154Narrow palate (HP:0000189)1.43716887
155Arterial thrombosis (HP:0004420)1.43668683
156Large earlobe (HP:0009748)1.43087268
157Skin pits (HP:0100276)1.42968459
158Anteriorly placed anus (HP:0001545)1.41939452
159Progressive hearing impairment (HP:0001730)1.41878912
160Peritonitis (HP:0002586)1.41174890
161Laryngomalacia (HP:0001601)1.40825339

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.48643673
2RIPK43.41339223
3CDK123.17259927
4MAP4K13.01400539
5MAP3K142.91044070
6CHUK2.54300192
7MKNK22.36586662
8EPHB12.33264451
9MAPK152.31980005
10IKBKB2.24598038
11PIM22.21996809
12NLK2.17717673
13BLK2.08640737
14TRIB32.06913925
15EPHA31.80126217
16IRAK31.74144998
17MAP3K101.73465918
18TNK21.70184588
19MKNK11.64446648
20IKBKE1.64012454
21PIM11.57863973
22BRD41.57396329
23ZAP701.57379786
24ITK1.56987863
25MAP3K11.41983704
26IRAK41.41109378
27CSK1.38530892
28TGFBR21.37045316
29MAP3K131.36915793
30PRPF4B1.32702679
31MAP3K31.29256745
32CLK11.28840390
33TBK11.27777115
34RPS6KA51.27500428
35IRAK11.20571764
36CDC42BPA1.17757103
37DMPK1.16876775
38MARK21.16593470
39TAOK11.16458446
40SIK21.14530137
41SMG11.13980371
42JAK31.11655229
43ICK1.10714303
44KSR21.09438377
45HIPK21.08702156
46JAK21.06663660
47TEC1.06485063
48STK101.04971833
49SIK31.04361244
50MAP3K111.03886682
51MATK1.02561181
52MST41.01242787
53JAK10.99605281
54HCK0.98303823
55SYK0.98161119
56MUSK0.93362740
57GSK3A0.93312181
58PTK60.92293707
59NUAK10.88891589
60TAOK30.88777968
61LYN0.87424140
62TAOK20.87235986
63LCK0.87136257
64RPS6KA10.86401213
65RPS6KA40.86365980
66BTK0.83398024
67TNIK0.83164803
68EPHB20.82090807
69FES0.79989028
70PDGFRB0.79399737
71BMX0.79105355
72MAP2K20.76794575
73IRAK20.76469732
74CDK90.75909226
75SGK30.71820702
76PRKD20.70754706
77PDK10.70631020
78PAK20.70546434
79PDPK10.68842128
80DYRK1B0.68607149
81UHMK10.67445300
82MAPK120.67400550
83CSF1R0.64122564
84FGFR30.63456714
85PKN20.62238235
86GRK60.61939763
87YES10.61424173
88SIK10.61305722
89WNK10.61098030
90PKN10.60943935
91BMPR20.60496927
92MTOR0.60048604
93CAMK1D0.59979941
94MAP2K30.59622581
95MAPKAPK20.59143641
96RPS6KA20.58888685
97RPS6KA60.58809249
98CAMK40.58616964
99MAP3K60.58113371
100SGK20.57955211
101TGFBR10.57602337
102EIF2AK20.56968307
103FGFR40.56033254
104CAMKK10.55944161
105MARK30.55775585
106DYRK20.54855862
107TYRO30.54689468
108FGR0.54213226
109BMPR1B0.53456492
110MAP3K70.51658407
111LATS10.50144409
112KIT0.49756425
113DDR20.49667450
114EEF2K0.48544574
115STK110.47584109
116MELK0.47256691
117NTRK20.46989444
118RET0.46587374
119TYK20.46403461
120CAMK1G0.46119482
121RPS6KC10.46033911
122RPS6KL10.46033911
123GRK70.45911083
124FYN0.45610962
125MAPK70.44101806
126CDK30.43891838
127INSR0.43797909
128LRRK20.43618886
129ERN10.43344622
130MAP3K50.43191472
131PNCK0.42529071
132ABL10.42190976
133RIPK10.41868684
134EPHA20.41048267
135MAP3K20.41021607
136SRPK10.40787326
137PRKCZ0.38589444
138SGK2230.38052589
139SGK4940.38052589
140STK380.37585298

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.66111704
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.57361199
3T cell receptor signaling pathway_Homo sapiens_hsa046602.23925095
4Allograft rejection_Homo sapiens_hsa053302.07221418
5Osteoclast differentiation_Homo sapiens_hsa043802.02008296
6Staphylococcus aureus infection_Homo sapiens_hsa051501.85222567
7Primary immunodeficiency_Homo sapiens_hsa053401.85043763
8Leishmaniasis_Homo sapiens_hsa051401.78369748
9Asthma_Homo sapiens_hsa053101.77116207
10Notch signaling pathway_Homo sapiens_hsa043301.72383072
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.70070283
12Graft-versus-host disease_Homo sapiens_hsa053321.69969276
13Measles_Homo sapiens_hsa051621.69439969
14Acute myeloid leukemia_Homo sapiens_hsa052211.68037393
15Autoimmune thyroid disease_Homo sapiens_hsa053201.64540890
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63887557
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58313656
18TNF signaling pathway_Homo sapiens_hsa046681.57470239
19Transcriptional misregulation in cancer_Homo sapiens_hsa052021.57154150
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.56377351
21Toxoplasmosis_Homo sapiens_hsa051451.47064042
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.46310054
23Malaria_Homo sapiens_hsa051441.45538629
24Chronic myeloid leukemia_Homo sapiens_hsa052201.39792438
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36554999
26Hematopoietic cell lineage_Homo sapiens_hsa046401.31440797
27B cell receptor signaling pathway_Homo sapiens_hsa046621.30555537
28MicroRNAs in cancer_Homo sapiens_hsa052061.29773678
29Viral myocarditis_Homo sapiens_hsa054161.27823600
30Herpes simplex infection_Homo sapiens_hsa051681.27224926
31Non-small cell lung cancer_Homo sapiens_hsa052231.24257391
32Prolactin signaling pathway_Homo sapiens_hsa049171.22628257
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21582486
34Hepatitis B_Homo sapiens_hsa051611.20507183
35Other glycan degradation_Homo sapiens_hsa005111.18550845
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16900143
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15834305
38Small cell lung cancer_Homo sapiens_hsa052221.15763785
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15073913
40HTLV-I infection_Homo sapiens_hsa051661.11429743
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09434989
42Apoptosis_Homo sapiens_hsa042101.06395964
43Basal cell carcinoma_Homo sapiens_hsa052171.04436478
44Prostate cancer_Homo sapiens_hsa052151.02350168
45Influenza A_Homo sapiens_hsa051640.98654753
46Chemokine signaling pathway_Homo sapiens_hsa040620.98349218
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97964870
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.97472653
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97381297
50Legionellosis_Homo sapiens_hsa051340.96908441
51Adherens junction_Homo sapiens_hsa045200.95864401
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95111286
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94125066
54MAPK signaling pathway_Homo sapiens_hsa040100.92425153
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91596562
56Axon guidance_Homo sapiens_hsa043600.90805639
57Pancreatic cancer_Homo sapiens_hsa052120.90671515
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90147595
59Shigellosis_Homo sapiens_hsa051310.89896058
60Type II diabetes mellitus_Homo sapiens_hsa049300.88860350
61Colorectal cancer_Homo sapiens_hsa052100.88432097
62Wnt signaling pathway_Homo sapiens_hsa043100.86891697
63Pertussis_Homo sapiens_hsa051330.85373060
64Renal cell carcinoma_Homo sapiens_hsa052110.84697812
65Hepatitis C_Homo sapiens_hsa051600.84695601
66Salmonella infection_Homo sapiens_hsa051320.84179256
67Phagosome_Homo sapiens_hsa041450.83956327
68TGF-beta signaling pathway_Homo sapiens_hsa043500.82908124
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.82848792
70Epstein-Barr virus infection_Homo sapiens_hsa051690.82816972
71mTOR signaling pathway_Homo sapiens_hsa041500.81975757
72Pathways in cancer_Homo sapiens_hsa052000.81493597
73African trypanosomiasis_Homo sapiens_hsa051430.81366555
74Ribosome_Homo sapiens_hsa030100.81073215
75Type I diabetes mellitus_Homo sapiens_hsa049400.78135459
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77946706
77Choline metabolism in cancer_Homo sapiens_hsa052310.77036485
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.76109950
79GnRH signaling pathway_Homo sapiens_hsa049120.75245834
80Amoebiasis_Homo sapiens_hsa051460.75112005
81Spliceosome_Homo sapiens_hsa030400.73397205
82Prion diseases_Homo sapiens_hsa050200.73281212
83Circadian rhythm_Homo sapiens_hsa047100.73165259
84HIF-1 signaling pathway_Homo sapiens_hsa040660.72461322
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72396744
86Dorso-ventral axis formation_Homo sapiens_hsa043200.71606517
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71566941
88Tuberculosis_Homo sapiens_hsa051520.70216407
89Viral carcinogenesis_Homo sapiens_hsa052030.69938255
90Rheumatoid arthritis_Homo sapiens_hsa053230.69890839
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69288455
92Bladder cancer_Homo sapiens_hsa052190.68251416
93Endocytosis_Homo sapiens_hsa041440.66005108
94Hippo signaling pathway_Homo sapiens_hsa043900.65722023
95Proteoglycans in cancer_Homo sapiens_hsa052050.65643350
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65492391
97ECM-receptor interaction_Homo sapiens_hsa045120.64609352
98FoxO signaling pathway_Homo sapiens_hsa040680.63615373
99Platelet activation_Homo sapiens_hsa046110.61103962
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60858887
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60758689
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60666421
103Antigen processing and presentation_Homo sapiens_hsa046120.60482655
104Lysosome_Homo sapiens_hsa041420.60474095
105Focal adhesion_Homo sapiens_hsa045100.60404551
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59626085
107Insulin signaling pathway_Homo sapiens_hsa049100.59449138
108Hedgehog signaling pathway_Homo sapiens_hsa043400.59378539
109ErbB signaling pathway_Homo sapiens_hsa040120.57246667
110Ras signaling pathway_Homo sapiens_hsa040140.57132269
111Endometrial cancer_Homo sapiens_hsa052130.56990351
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56895037
113Inositol phosphate metabolism_Homo sapiens_hsa005620.56651895
114Lysine degradation_Homo sapiens_hsa003100.56629631
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56057305
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55264996
117Estrogen signaling pathway_Homo sapiens_hsa049150.54999108
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.54843055
119Rap1 signaling pathway_Homo sapiens_hsa040150.53699070
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.53414415
121Sphingolipid metabolism_Homo sapiens_hsa006000.52507346
122VEGF signaling pathway_Homo sapiens_hsa043700.51038698
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.50344690
124Cocaine addiction_Homo sapiens_hsa050300.49449772
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48600560
126Glioma_Homo sapiens_hsa052140.48157687
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45360668
128Insulin resistance_Homo sapiens_hsa049310.44659140
129p53 signaling pathway_Homo sapiens_hsa041150.44239642

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