KDM5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.31541963
2nuclear pore organization (GO:0006999)5.22443117
3regulation of gene silencing by RNA (GO:0060966)4.68140853
4regulation of posttranscriptional gene silencing (GO:0060147)4.68140853
5regulation of gene silencing by miRNA (GO:0060964)4.68140853
6paraxial mesoderm development (GO:0048339)4.22982246
7pyrimidine nucleobase catabolic process (GO:0006208)4.14543184
8pre-miRNA processing (GO:0031054)3.99360197
9pore complex assembly (GO:0046931)3.98260344
10regulation of histone H3-K9 methylation (GO:0051570)3.92694046
11regulation of helicase activity (GO:0051095)3.84447803
12negative regulation of histone methylation (GO:0031061)3.81260012
13piRNA metabolic process (GO:0034587)3.76714920
14DNA replication-dependent nucleosome organization (GO:0034723)3.67571903
15DNA replication-dependent nucleosome assembly (GO:0006335)3.67571903
16regulation of meiosis I (GO:0060631)3.59665558
17gastrulation with mouth forming second (GO:0001702)3.59372357
18histone H4-K12 acetylation (GO:0043983)3.58029469
19negative regulation of DNA repair (GO:0045738)3.40705356
20mitotic metaphase plate congression (GO:0007080)3.38522286
21synaptonemal complex assembly (GO:0007130)3.33845905
22mitotic nuclear envelope disassembly (GO:0007077)3.31381067
23mitotic sister chromatid cohesion (GO:0007064)3.31277208
24somatic diversification of immune receptors via somatic mutation (GO:0002566)3.26274625
25somatic hypermutation of immunoglobulin genes (GO:0016446)3.26274625
26microtubule depolymerization (GO:0007019)3.25120318
27regulation of RNA export from nucleus (GO:0046831)3.24246231
28histone H2A monoubiquitination (GO:0035518)3.21555593
29regulation of telomere maintenance via telomerase (GO:0032210)3.20552262
30male meiosis (GO:0007140)3.20541582
31cell migration in hindbrain (GO:0021535)3.19456209
32protein localization to kinetochore (GO:0034501)3.16924087
33protein K6-linked ubiquitination (GO:0085020)3.14347749
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.13538160
35histone H4-K8 acetylation (GO:0043982)3.13243208
36histone H4-K5 acetylation (GO:0043981)3.13243208
37nuclear envelope disassembly (GO:0051081)3.12078836
38membrane disassembly (GO:0030397)3.12078836
39synaptonemal complex organization (GO:0070193)3.11361751
40DNA methylation involved in gamete generation (GO:0043046)3.10798441
41gene silencing by RNA (GO:0031047)3.08682542
42histone arginine methylation (GO:0034969)3.08011890
43nucleobase catabolic process (GO:0046113)3.06196735
44heterochromatin organization (GO:0070828)3.03943341
45regulation of gene silencing (GO:0060968)3.03674308
46histone H3-K9 methylation (GO:0051567)3.03590768
47metaphase plate congression (GO:0051310)3.02224000
48regulation of hippo signaling (GO:0035330)3.01541891
49peptidyl-arginine omega-N-methylation (GO:0035247)3.01260322
50limb bud formation (GO:0060174)3.00572143
51presynaptic membrane assembly (GO:0097105)2.99656474
52DNA alkylation (GO:0006305)2.98332172
53DNA methylation (GO:0006306)2.98332172
54negative regulation of chromosome segregation (GO:0051985)2.97327213
55spliceosomal tri-snRNP complex assembly (GO:0000244)2.94892960
56negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.93577859
57negative regulation of translation, ncRNA-mediated (GO:0040033)2.93577859
58regulation of translation, ncRNA-mediated (GO:0045974)2.93577859
59dosage compensation (GO:0007549)2.91730883
60chromatin assembly (GO:0031497)2.91537319
61histone H2A acetylation (GO:0043968)2.89753493
62artery development (GO:0060840)2.89034142
63axonal fasciculation (GO:0007413)2.89008072
64synapsis (GO:0007129)2.88967818
65negative regulation of mitotic sister chromatid separation (GO:2000816)2.88899693
66negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88899693
67negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88899693
68negative regulation of sister chromatid segregation (GO:0033046)2.88899693
69regulation of chromosome segregation (GO:0051983)2.88888866
70DNA geometric change (GO:0032392)2.87850324
71mitotic spindle checkpoint (GO:0071174)2.87637792
72negative regulation of histone modification (GO:0031057)2.86847730
73DNA duplex unwinding (GO:0032508)2.86649180
74regulation of centriole replication (GO:0046599)2.86349707
75embryonic foregut morphogenesis (GO:0048617)2.85485687
76spindle assembly checkpoint (GO:0071173)2.84754651
77mitotic spindle assembly checkpoint (GO:0007094)2.83747771
78negative regulation of chromatin modification (GO:1903309)2.83732561
79positive regulation of chromosome segregation (GO:0051984)2.82325923
80sister chromatid segregation (GO:0000819)2.81695397
81mitotic sister chromatid segregation (GO:0000070)2.81460419
82regulation of spindle organization (GO:0090224)2.81325167
83spindle checkpoint (GO:0031577)2.81274793
84negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.78642895
85DNA unwinding involved in DNA replication (GO:0006268)2.78074934
86intra-S DNA damage checkpoint (GO:0031573)2.77640945
87anterior/posterior axis specification, embryo (GO:0008595)2.77569651
88peptidyl-arginine N-methylation (GO:0035246)2.77294631
89peptidyl-arginine methylation (GO:0018216)2.77294631
90DNA synthesis involved in DNA repair (GO:0000731)2.76590580
91kinetochore organization (GO:0051383)2.76549663
92regulation of mitotic metaphase/anaphase transition (GO:0030071)2.76535719
93mRNA transport (GO:0051028)2.76183488
94presynaptic membrane organization (GO:0097090)2.76179041
95regulation of DNA damage checkpoint (GO:2000001)2.75085570
96protein localization to chromosome, centromeric region (GO:0071459)2.74825636
97regulation of mitotic sister chromatid segregation (GO:0033047)2.74475346
98regulation of sister chromatid segregation (GO:0033045)2.74475346
99regulation of mitotic sister chromatid separation (GO:0010965)2.74475346
100ATP-dependent chromatin remodeling (GO:0043044)2.73936241
101DNA replication initiation (GO:0006270)2.73766440
102DNA methylation or demethylation (GO:0044728)2.72931756
103IMP biosynthetic process (GO:0006188)2.72402494
104negative regulation of chromosome organization (GO:2001251)2.71947867
105regulation of sister chromatid cohesion (GO:0007063)2.71851299
106nucleosome disassembly (GO:0006337)2.71619912
107protein-DNA complex disassembly (GO:0032986)2.71619912
108nucleobase biosynthetic process (GO:0046112)2.71212490
109regulation of protein polyubiquitination (GO:1902914)2.69876105
110mitotic chromosome condensation (GO:0007076)2.69839835
111ephrin receptor signaling pathway (GO:0048013)2.69672452
112sister chromatid cohesion (GO:0007062)2.68979202
113regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.68891010
114calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.67869934
115positive regulation of mitotic sister chromatid separation (GO:1901970)2.67139795
116positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.67139795
117positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.67139795
118meiotic nuclear division (GO:0007126)2.67134791
119positive regulation of SMAD protein import into nucleus (GO:0060391)2.66840482
120olfactory bulb development (GO:0021772)2.62397633
121neuron recognition (GO:0008038)2.60475518
122axon extension involved in axon guidance (GO:0048846)2.56470753
123neuron projection extension involved in neuron projection guidance (GO:1902284)2.56470753
124regulation of telomere maintenance (GO:0032204)2.47734631
125sympathetic nervous system development (GO:0048485)2.46859995
126chromosome organization involved in meiosis (GO:0070192)2.45233647
127embryonic body morphogenesis (GO:0010172)2.44538711
128ectoderm development (GO:0007398)2.43534695
129establishment of planar polarity (GO:0001736)2.42839979
130establishment of tissue polarity (GO:0007164)2.42839979
131regulation of growth hormone secretion (GO:0060123)2.42182984
132establishment or maintenance of monopolar cell polarity (GO:0061339)2.42146843
133establishment of monopolar cell polarity (GO:0061162)2.42146843
134lung-associated mesenchyme development (GO:0060484)2.40128940
135resolution of meiotic recombination intermediates (GO:0000712)2.40068183
136head development (GO:0060322)2.39220529
137neuronal stem cell maintenance (GO:0097150)2.38632701
138body morphogenesis (GO:0010171)2.37211950
139spinal cord development (GO:0021510)2.36993322
140convergent extension (GO:0060026)2.36624797
141appendage development (GO:0048736)2.35424891
142limb development (GO:0060173)2.35424891
143central nervous system projection neuron axonogenesis (GO:0021952)2.35385743
144regulation of NFAT protein import into nucleus (GO:0051532)2.34683334
145dorsal/ventral axis specification (GO:0009950)2.33178710
146positive regulation of dendritic spine morphogenesis (GO:0061003)2.32726637
147negative regulation of keratinocyte proliferation (GO:0010839)2.32355954
148neuron cell-cell adhesion (GO:0007158)2.32274110
149intraciliary transport (GO:0042073)2.32040181
150somite development (GO:0061053)2.31375879
151lateral sprouting from an epithelium (GO:0060601)2.30579766
152RNA localization (GO:0006403)2.28544209
153proximal/distal pattern formation (GO:0009954)2.26223701
154male meiosis I (GO:0007141)2.26198981
155layer formation in cerebral cortex (GO:0021819)2.24177552
156regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.24084074
157establishment of mitochondrion localization (GO:0051654)2.23935794
158retinal ganglion cell axon guidance (GO:0031290)2.21959100
159single strand break repair (GO:0000012)2.20912984
160ganglion development (GO:0061548)2.20785063
161apical protein localization (GO:0045176)2.19587942
162DNA damage response, detection of DNA damage (GO:0042769)2.19534323
163organ growth (GO:0035265)2.18875320
164negative regulation of oligodendrocyte differentiation (GO:0048715)2.18502882
165cardiac right ventricle morphogenesis (GO:0003215)2.18212744
166microtubule anchoring (GO:0034453)2.17931531
167morphogenesis of an epithelial sheet (GO:0002011)2.16988898
168dendrite morphogenesis (GO:0048813)2.16882266
169planar cell polarity pathway involved in neural tube closure (GO:0090179)2.16492182
170negative chemotaxis (GO:0050919)2.15791233
171neural tube formation (GO:0001841)2.15351795
172histone H3-K9 demethylation (GO:0033169)2.13964667
173establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.13757404
174postsynaptic membrane organization (GO:0001941)2.13554481
175generation of neurons (GO:0048699)2.13514556
176G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.13275011
177regulation of cell fate specification (GO:0042659)2.12255524
178ectodermal placode formation (GO:0060788)2.11969855
179hippocampus development (GO:0021766)2.11762773
180pyrimidine dimer repair (GO:0006290)2.11367417
181DNA damage induced protein phosphorylation (GO:0006975)2.11354951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.59993519
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.03638917
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.84252508
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.61260579
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36350696
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.31585325
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.31585325
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.31585325
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.15567696
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.06620680
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.93244256
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70937209
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.67223334
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60344552
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56200026
16SOX2_18555785_ChIP-Seq_MESCs_Mouse2.52639709
17IGF1R_20145208_ChIP-Seq_DFB_Human2.49791294
18NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.42723000
19ZNF274_21170338_ChIP-Seq_K562_Hela2.29650417
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.27748056
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.26443300
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.21939073
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20479526
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.18248575
25FUS_26573619_Chip-Seq_HEK293_Human2.15322823
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.14513035
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10646857
28NANOG_18555785_ChIP-Seq_MESCs_Mouse2.09750286
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.08068977
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06309597
31TCF3_18692474_ChIP-Seq_MESCs_Mouse2.05612710
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03577566
33SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.00181328
34GBX2_23144817_ChIP-Seq_PC3_Human1.98420400
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97270359
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.92522826
37TAF15_26573619_Chip-Seq_HEK293_Human1.91828757
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91822224
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89386913
40TCF3_18692474_ChIP-Seq_MEFs_Mouse1.88409381
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.86602110
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86332980
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85622001
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84291390
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82374907
46EWS_26573619_Chip-Seq_HEK293_Human1.80538156
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.76970904
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.75266962
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.74863889
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69123645
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.68553755
52RNF2_27304074_Chip-Seq_NSC_Mouse1.68483296
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.64359410
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.63221443
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62935666
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62711255
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60196871
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59995294
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58956199
60XRN2_22483619_ChIP-Seq_HELA_Human1.56784492
61NANOG_21062744_ChIP-ChIP_HESCs_Human1.56509119
62NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.53484126
63P300_19829295_ChIP-Seq_ESCs_Human1.51769069
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50886370
65NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.50396774
66AR_21909140_ChIP-Seq_LNCAP_Human1.50068501
67EZH2_22144423_ChIP-Seq_EOC_Human1.49508579
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48663297
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47624262
70SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.47541480
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.46995722
72POU5F1_16518401_ChIP-PET_MESCs_Mouse1.44268998
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44170217
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.43530460
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43238506
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43238506
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42546968
78SOX2_18692474_ChIP-Seq_MESCs_Mouse1.38954247
79SOX2_16153702_ChIP-ChIP_HESCs_Human1.38106741
80POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.36178298
81TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.35017732
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.34559604
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33234996
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31826334
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.31079751
86* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29611816
87TTF2_22483619_ChIP-Seq_HELA_Human1.27618043
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27138717
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.26831069
90EZH2_27304074_Chip-Seq_ESCs_Mouse1.26726718
91SMAD4_21799915_ChIP-Seq_A2780_Human1.25114927
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24620241
93TBX3_20139965_ChIP-Seq_ESCs_Mouse1.24168005
94CIITA_25753668_ChIP-Seq_RAJI_Human1.24143684
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23944221
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23636328
97TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23415247
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.23291987
99ETS1_20019798_ChIP-Seq_JURKAT_Human1.22569707
100* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22542624
101CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22053206
102THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19940170
103ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19691985
104NANOG_16153702_ChIP-ChIP_HESCs_Human1.18571809
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18555760
106SOX9_26525672_Chip-Seq_HEART_Mouse1.17776037
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16911577
108E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16216132
109NANOG_18692474_ChIP-Seq_MESCs_Mouse1.15618285
110GATA1_26923725_Chip-Seq_HPCs_Mouse1.15573033
111KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15210688
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14125708
113KDM5A_27292631_Chip-Seq_BREAST_Human1.13714767
114* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.13647276
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13174085
116CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12408120
117ER_23166858_ChIP-Seq_MCF-7_Human1.12063097
118FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11949243
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11670617
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09521004
121ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09438138
122PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08988656
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08108059
124PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07701214
125ELK1_19687146_ChIP-ChIP_HELA_Human1.06775567
126ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06551899
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06386945
128POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.06048223
129SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05978385
130AR_21572438_ChIP-Seq_LNCaP_Human1.05867763
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05233696
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05209407
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05111475
134* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04699484
135* STAT3_23295773_ChIP-Seq_U87_Human1.04366511
136GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04358439
137KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04173228
138YY1_21170310_ChIP-Seq_MESCs_Mouse1.03952426
139ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02437521
140PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.01912476
141IRF1_19129219_ChIP-ChIP_H3396_Human1.01283322
142VDR_23849224_ChIP-Seq_CD4+_Human1.00028032
143JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98736459
144NANOG_18692474_ChIP-Seq_MEFs_Mouse0.98579296
145EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98574121
146TCF4_18268006_ChIP-ChIP_LS174T_Human0.98211749
147VDR_22108803_ChIP-Seq_LS180_Human0.98039318
148* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97881730
149PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97477081
150FOXP3_21729870_ChIP-Seq_TREG_Human0.96835371
151EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96822291
152TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96531081
153MYC_18940864_ChIP-ChIP_HL60_Human0.96378053
154YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95412512
155KAP1_27257070_Chip-Seq_ESCs_Mouse0.94527759
156* RUNX2_22187159_ChIP-Seq_PCA_Human0.93966988
157KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.91470438
158PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91393389
159GABP_19822575_ChIP-Seq_HepG2_Human0.91276952
160* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91177751
161TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91154037
162CBP_20019798_ChIP-Seq_JUKART_Human0.89807013
163IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89807013
164TCF4_23295773_ChIP-Seq_U87_Human0.89152451
165UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88697161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.20704956
2MP0010094_abnormal_chromosome_stability3.05293711
3MP0008057_abnormal_DNA_replication2.97276201
4MP0003111_abnormal_nucleus_morphology2.93340983
5MP0002653_abnormal_ependyma_morphology2.88204508
6MP0003693_abnormal_embryo_hatching2.54490228
7MP0008058_abnormal_DNA_repair2.51998693
8MP0003077_abnormal_cell_cycle2.51431781
9MP0004957_abnormal_blastocyst_morpholog2.48925912
10MP0010030_abnormal_orbit_morphology2.44815008
11MP0003121_genomic_imprinting2.42705760
12MP0003123_paternal_imprinting2.40432220
13MP0003890_abnormal_embryonic-extraembry2.30059358
14MP0008007_abnormal_cellular_replicative2.11194634
15MP0006292_abnormal_olfactory_placode2.08915342
16MP0003880_abnormal_central_pattern2.03287751
17MP0000537_abnormal_urethra_morphology1.99946951
18MP0003119_abnormal_digestive_system1.91441145
19MP0003786_premature_aging1.87579716
20MP0002084_abnormal_developmental_patter1.86743247
21MP0008995_early_reproductive_senescence1.86235526
22MP0001293_anophthalmia1.81688297
23MP0003941_abnormal_skin_development1.81398788
24MP0004133_heterotaxia1.80573893
25MP0002085_abnormal_embryonic_tissue1.79061546
26MP0001730_embryonic_growth_arrest1.79012175
27MP0000350_abnormal_cell_proliferation1.76437649
28MP0002210_abnormal_sex_determination1.74795708
29MP0004197_abnormal_fetal_growth/weight/1.68950389
30MP0008932_abnormal_embryonic_tissue1.67554531
31MP0003937_abnormal_limbs/digits/tail_de1.65931090
32MP0003122_maternal_imprinting1.63845774
33MP0000579_abnormal_nail_morphology1.62997020
34MP0005380_embryogenesis_phenotype1.62899823
35MP0001672_abnormal_embryogenesis/_devel1.62899823
36MP0003787_abnormal_imprinting1.59390002
37MP0009053_abnormal_anal_canal1.57984723
38MP0001529_abnormal_vocalization1.56467225
39MP0005076_abnormal_cell_differentiation1.53383073
40MP0010352_gastrointestinal_tract_polyps1.50162981
41MP0001145_abnormal_male_reproductive1.47410592
42MP0003315_abnormal_perineum_morphology1.46597160
43MP0001929_abnormal_gametogenesis1.46294281
44MP0001188_hyperpigmentation1.44295355
45MP0001697_abnormal_embryo_size1.42959280
46MP0008789_abnormal_olfactory_epithelium1.42725611
47MP0010307_abnormal_tumor_latency1.39614531
48MP0003861_abnormal_nervous_system1.38715585
49MP0003984_embryonic_growth_retardation1.38036525
50MP0006276_abnormal_autonomic_nervous1.37709965
51MP0002088_abnormal_embryonic_growth/wei1.36941731
52MP0005499_abnormal_olfactory_system1.36538427
53MP0005394_taste/olfaction_phenotype1.36538427
54MP0001299_abnormal_eye_distance/1.34828531
55MP0003698_abnormal_male_reproductive1.33769749
56MP0002249_abnormal_larynx_morphology1.32182491
57MP0002086_abnormal_extraembryonic_tissu1.31834452
58MP0005367_renal/urinary_system_phenotyp1.30665215
59MP0000516_abnormal_urinary_system1.30665215
60MP0001286_abnormal_eye_development1.30424214
61MP0002184_abnormal_innervation1.30192166
62MP0002822_catalepsy1.29230733
63MP0002697_abnormal_eye_size1.26254428
64MP0000647_abnormal_sebaceous_gland1.26198778
65MP0004270_analgesia1.26114125
66MP0000653_abnormal_sex_gland1.25908544
67MP0006072_abnormal_retinal_apoptosis1.25101264
68MP0000566_synostosis1.24840576
69MP0000955_abnormal_spinal_cord1.23894261
70MP0003136_yellow_coat_color1.23630046
71MP0003283_abnormal_digestive_organ1.23044666
72MP0003755_abnormal_palate_morphology1.21040547
73MP0002080_prenatal_lethality1.18244183
74MP0003115_abnormal_respiratory_system1.17597792
75MP0003935_abnormal_craniofacial_develop1.16697055
76MP0004264_abnormal_extraembryonic_tissu1.16124481
77MP0003942_abnormal_urinary_system1.15964655
78MP0005377_hearing/vestibular/ear_phenot1.15834325
79MP0003878_abnormal_ear_physiology1.15834325
80MP0000383_abnormal_hair_follicle1.12690184
81MP0000428_abnormal_craniofacial_morphol1.12181949
82MP0002160_abnormal_reproductive_system1.11971721
83MP0000432_abnormal_head_morphology1.11729328
84MP0002092_abnormal_eye_morphology1.11714909
85MP0005623_abnormal_meninges_morphology1.11678313
86MP0009703_decreased_birth_body1.09861262
87MP0003567_abnormal_fetal_cardiomyocyte1.09760520
88MP0002102_abnormal_ear_morphology1.09424665
89MP0000049_abnormal_middle_ear1.08697128
90MP0002938_white_spotting1.08401626
91MP0002233_abnormal_nose_morphology1.08264856
92MP0002152_abnormal_brain_morphology1.06943792
93MP0002234_abnormal_pharynx_morphology1.05853854
94MP0002111_abnormal_tail_morphology1.05044148
95MP0005423_abnormal_somatic_nervous1.04945834
96MP0000778_abnormal_nervous_system1.03813517
97MP0003938_abnormal_ear_development1.03364727
98MP0001849_ear_inflammation1.02454510
99MP0000569_abnormal_digit_pigmentation1.02247443
100MP0005187_abnormal_penis_morphology1.01982861
101MP0005391_vision/eye_phenotype1.01161011
102MP0001984_abnormal_olfaction1.00992040
103MP0003385_abnormal_body_wall0.99650193
104MP0005410_abnormal_fertilization0.98596922
105MP0002116_abnormal_craniofacial_bone0.96662432
106MP0002282_abnormal_trachea_morphology0.96137457
107MP0005248_abnormal_Harderian_gland0.95910510
108MP0009672_abnormal_birth_weight0.94952633
109MP0004811_abnormal_neuron_physiology0.91972426
110MP0002751_abnormal_autonomic_nervous0.91557611
111MP0000534_abnormal_ureter_morphology0.89307635
112MP0002114_abnormal_axial_skeleton0.88425156
113MP0004272_abnormal_basement_membrane0.87979731
114MP0001177_atelectasis0.87642328
115MP0002161_abnormal_fertility/fecundity0.86121733
116MP0003718_maternal_effect0.84329904
117MP0003936_abnormal_reproductive_system0.84169145
118MP0000427_abnormal_hair_cycle0.83997836
119MP0002882_abnormal_neuron_morphology0.83922781
120MP0009250_abnormal_appendicular_skeleto0.83812033
121MP0002752_abnormal_somatic_nervous0.83155274
122MP0005253_abnormal_eye_physiology0.79202541
123MP0002081_perinatal_lethality0.79081075
124MP0002932_abnormal_joint_morphology0.78336041
125MP0000631_abnormal_neuroendocrine_gland0.77866638

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.02167258
2Abnormality of the labia minora (HP:0012880)3.86556557
3Astrocytoma (HP:0009592)3.44346094
4Abnormality of the astrocytes (HP:0100707)3.44346094
5Medulloblastoma (HP:0002885)3.24827566
6Supernumerary spleens (HP:0009799)3.08983638
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.08233493
8Chromsome breakage (HP:0040012)2.94836473
9Neoplasm of the oral cavity (HP:0100649)2.94724522
10Glioma (HP:0009733)2.93099761
11Cortical dysplasia (HP:0002539)2.81742306
12Hepatoblastoma (HP:0002884)2.79672556
13Selective tooth agenesis (HP:0001592)2.70163737
14Impulsivity (HP:0100710)2.65209166
15Abnormality of the aortic arch (HP:0012303)2.61873473
16Abnormality of the lower motor neuron (HP:0002366)2.61452701
17Patellar aplasia (HP:0006443)2.57745342
18Absent radius (HP:0003974)2.51996881
19Colon cancer (HP:0003003)2.51587126
20Missing ribs (HP:0000921)2.49645532
21Shawl scrotum (HP:0000049)2.49295115
22Aplasia/Hypoplasia of the patella (HP:0006498)2.40178229
23Ectopic kidney (HP:0000086)2.39814372
24Aplasia involving forearm bones (HP:0009822)2.38640752
25Absent forearm bone (HP:0003953)2.38640752
26Rhabdomyosarcoma (HP:0002859)2.36764547
27Drooling (HP:0002307)2.34356059
28Aplasia/Hypoplasia of the sternum (HP:0006714)2.32354445
29Birth length less than 3rd percentile (HP:0003561)2.31089907
3011 pairs of ribs (HP:0000878)2.30918264
31Meckel diverticulum (HP:0002245)2.30380615
32Breast hypoplasia (HP:0003187)2.27213520
33Rib fusion (HP:0000902)2.26343500
34Cutaneous finger syndactyly (HP:0010554)2.25832530
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.24683608
36Short 4th metacarpal (HP:0010044)2.24683608
37Midline defect of the nose (HP:0004122)2.24063429
38Nephroblastoma (Wilms tumor) (HP:0002667)2.23193401
39Neoplasm of striated muscle (HP:0009728)2.22122417
40Abnormality of the ileum (HP:0001549)2.22062359
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.20310773
42Supernumerary ribs (HP:0005815)2.20127822
43Aplasia/hypoplasia of the humerus (HP:0006507)2.19721886
44Esophageal atresia (HP:0002032)2.18444749
45Abdominal situs inversus (HP:0003363)2.16542774
46Abnormality of abdominal situs (HP:0011620)2.16542774
47Abnormal number of incisors (HP:0011064)2.15384428
48Cutaneous syndactyly (HP:0012725)2.14597143
49Short humerus (HP:0005792)2.14177287
50Anal stenosis (HP:0002025)2.12841627
51Embryonal renal neoplasm (HP:0011794)2.11582204
52Degeneration of anterior horn cells (HP:0002398)2.09267654
53Abnormality of the anterior horn cell (HP:0006802)2.09267654
54Supernumerary bones of the axial skeleton (HP:0009144)2.08887427
55Volvulus (HP:0002580)2.06867766
56Facial hemangioma (HP:0000329)2.05017214
57Facial cleft (HP:0002006)2.04719635
58Heterotopia (HP:0002282)2.01647465
59Excessive salivation (HP:0003781)2.01451992
60Proximal placement of thumb (HP:0009623)2.01118832
61Increased nuchal translucency (HP:0010880)2.00741963
62Abnormality of chromosome stability (HP:0003220)1.99868053
63Renal hypoplasia (HP:0000089)1.99799957
64Aqueductal stenosis (HP:0002410)1.99170109
65Renal duplication (HP:0000075)1.99093428
66Vitreoretinal degeneration (HP:0000655)1.97551892
67Papillary thyroid carcinoma (HP:0002895)1.97200383
68Deviation of the thumb (HP:0009603)1.94632133
69Exotropia (HP:0000577)1.93740793
70Gonadotropin excess (HP:0000837)1.93686307
71Duodenal stenosis (HP:0100867)1.93119800
72Small intestinal stenosis (HP:0012848)1.93119800
73Curly hair (HP:0002212)1.90002708
74Tubulointerstitial nephritis (HP:0001970)1.89827282
75Myelomeningocele (HP:0002475)1.89124405
76Genital tract atresia (HP:0001827)1.88962264
77Gastrointestinal atresia (HP:0002589)1.88872914
78Oligodactyly (HP:0012165)1.88832951
79High anterior hairline (HP:0009890)1.88667612
80Anophthalmia (HP:0000528)1.88437707
81Vaginal atresia (HP:0000148)1.87771938
82Abnormality of the preputium (HP:0100587)1.86850943
83Abnormal lung lobation (HP:0002101)1.86274700
84Hypoplastic labia majora (HP:0000059)1.84999680
85Morphological abnormality of the middle ear (HP:0008609)1.83287946
86Abnormality of the carotid arteries (HP:0005344)1.80487058
87Abnormal sex determination (HP:0012244)1.79924337
88Sex reversal (HP:0012245)1.79924337
89Labial hypoplasia (HP:0000066)1.79571158
90Absent eyebrow (HP:0002223)1.79049282
91Poor coordination (HP:0002370)1.76842464
92Abnormality of the corticospinal tract (HP:0002492)1.76534059
93Vertebral arch anomaly (HP:0008438)1.75697324
94Biliary tract neoplasm (HP:0100574)1.75351399
95Pendular nystagmus (HP:0012043)1.75287200
96Agnosia (HP:0010524)1.75052670
97Micropenis (HP:0000054)1.74205471
98Septo-optic dysplasia (HP:0100842)1.73913859
99Hemivertebrae (HP:0002937)1.73472795
100Absent thumb (HP:0009777)1.72468643
101Rectal fistula (HP:0100590)1.71851634
102Rectovaginal fistula (HP:0000143)1.71851634
103Intestinal fistula (HP:0100819)1.71814912
104Abnormality of the duodenum (HP:0002246)1.71038176
105Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.68591664
106Cupped ear (HP:0000378)1.67405217
107Hypoplastic female external genitalia (HP:0012815)1.66816771
108Abnormality of the diencephalon (HP:0010662)1.66567299
109Oligodactyly (hands) (HP:0001180)1.66505580
110Severe Myopia (HP:0011003)1.65606806
111Intestinal atresia (HP:0011100)1.65466250
112Abnormality of the labia majora (HP:0012881)1.64630146
113Lissencephaly (HP:0001339)1.64354293
114Hypoplastic pelvis (HP:0008839)1.64301094
115Gastrointestinal carcinoma (HP:0002672)1.63905461
116Malignant gastrointestinal tract tumors (HP:0006749)1.63905461
117Sloping forehead (HP:0000340)1.63903864
118Long eyelashes (HP:0000527)1.63676204
119Chronic hepatic failure (HP:0100626)1.63632692
120Trigonocephaly (HP:0000243)1.63565887
121Skull defect (HP:0001362)1.63518444
122Short thumb (HP:0009778)1.62529213
123Optic nerve hypoplasia (HP:0000609)1.62488289
124Short 1st metacarpal (HP:0010034)1.62305729
125Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.62305729
126Broad alveolar ridges (HP:0000187)1.61538272
127Neoplasm of the pancreas (HP:0002894)1.61477120
128Spina bifida occulta (HP:0003298)1.61366419
129Preaxial hand polydactyly (HP:0001177)1.61238853
130Atresia of the external auditory canal (HP:0000413)1.60614312
131Genetic anticipation (HP:0003743)1.60438285
132Gait imbalance (HP:0002141)1.59629140
133Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.59607297
134Bifid tongue (HP:0010297)1.58439376
135Renovascular hypertension (HP:0100817)1.58319963
136Bicornuate uterus (HP:0000813)1.58177381
137Shoulder girdle muscle weakness (HP:0003547)1.58114870
138Thyroid carcinoma (HP:0002890)1.57054146
139Broad thumb (HP:0011304)1.56725351
140Preaxial foot polydactyly (HP:0001841)1.55530147
141Hip dysplasia (HP:0001385)1.55506957
142Obsessive-compulsive behavior (HP:0000722)1.54308047
143Congenital primary aphakia (HP:0007707)1.54104424
144Broad finger (HP:0001500)1.53574396
145Abnormality of the parathyroid morphology (HP:0011766)1.52923567
146Urinary urgency (HP:0000012)1.52773315
147Intellectual disability, moderate (HP:0002342)1.52737934
148Abnormality of the pubic bones (HP:0003172)1.52633511
149Omphalocele (HP:0001539)1.52489999
150Nephronophthisis (HP:0000090)1.52370190
151Dandy-Walker malformation (HP:0001305)1.52116485
152Broad foot (HP:0001769)1.51031063
153Abnormality of the septum pellucidum (HP:0007375)1.49992315
154Broad phalanges of the hand (HP:0009768)1.48890583
155Choanal stenosis (HP:0000452)1.48754775
156Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.48317576
157Degeneration of the lateral corticospinal tracts (HP:0002314)1.48317576
158Absent eyelashes (HP:0000561)1.47880760
159Pachygyria (HP:0001302)1.47829168
160Stenosis of the external auditory canal (HP:0000402)1.46590468
161Scrotal hypoplasia (HP:0000046)1.46195051
162Bilateral microphthalmos (HP:0007633)1.46165386

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.65549697
2CASK3.41327985
3CDC73.19641804
4WEE12.98353057
5BRD42.86888139
6SRPK12.78539301
7EPHA22.62122789
8PNCK2.49798325
9TRIM282.46919340
10AKT32.38905474
11TTK2.34207468
12LATS12.32599245
13NEK22.27586376
14BUB12.27538601
15MKNK11.95889864
16MKNK21.94853441
17DYRK31.86724175
18CDK71.84638061
19PLK11.78555002
20MAP4K21.78410647
21TNIK1.75948313
22CDK191.73174182
23PLK31.72534780
24CHEK21.72115891
25STK38L1.70862978
26MAP2K71.70811106
27PASK1.70562296
28LATS21.70508075
29ICK1.70298284
30ATR1.66207480
31RPS6KB21.65521468
32EPHA41.64941498
33ACVR1B1.63338103
34TSSK61.57744697
35CAMK1G1.56887896
36CHEK11.55683002
37NEK11.31443076
38TYRO31.26589748
39DYRK21.21952736
40ATM1.21783016
41STK31.21761033
42PLK41.19340597
43EEF2K1.18555348
44PKN21.17833100
45PDK31.17418644
46PDK41.17418644
47ZAK1.16411395
48TLK11.12110946
49CDK21.11625045
50KSR11.10797564
51ERBB31.10039218
52FLT31.09876765
53EPHA31.08984703
54BCR1.08632907
55MAP3K61.08443064
56MTOR1.07951638
57CSNK1G21.07078195
58AURKB1.06638160
59WNK31.04845660
60CSNK1G11.03857549
61TAF11.01563474
62ALK0.95606511
63AURKA0.95473808
64CDK10.92591988
65MINK10.90505723
66CSNK1G30.90306213
67FGFR10.90293390
68MARK10.87624768
69VRK10.86507375
70CDK40.84990708
71BRSK20.84642223
72MAP2K40.82297717
73MELK0.81185015
74CSNK1D0.80619156
75PRKCI0.79324773
76NTRK10.77131619
77RPS6KA40.75203669
78DYRK1B0.74730311
79YES10.73719064
80MAP3K50.72426306
81TGFBR10.72320594
82STK40.71827581
83PIK3CA0.70204830
84BMPR1B0.69689877
85NUAK10.69681364
86PLK20.69294797
87CSNK1E0.69067658
88CDK90.69026413
89MAP3K100.68335568
90PDK20.68305272
91PINK10.67479603
92MET0.67127256
93PAK40.66158186
94PBK0.63997141
95FGFR20.62894799
96PDGFRA0.62858169
97GSK3B0.62053883
98NTRK30.61587926
99PRKDC0.60272681
100MAPK140.60070602
101MAPK130.58868622
102PRKD30.58253667
103OXSR10.58167882
104AKT20.56583592
105DDR20.56507734
106RET0.54261730
107SIK20.54065585
108CDK60.53740240
109SGK2230.52945091
110SGK4940.52945091
111CSNK2A20.51006885
112MAP3K40.50956535
113PAK30.49262945
114SIK30.47508108
115MAPK100.47217825
116PRKCE0.47211327
117MAP3K80.46379672
118CDK180.45917875
119BRSK10.45825087
120DYRK1A0.45557903
121TAOK20.44536923
122AKT10.44147684
123MAPK10.44085466
124CDK30.43948270
125PRPF4B0.42995651
126CDK50.42492268
127CAMK1D0.42470069
128TESK20.42084176
129RPS6KB10.41388623
130PAK20.40675624
131NTRK20.40667407
132FER0.40368363
133CSNK1A1L0.40219841
134SCYL20.38994043
135PAK10.38685861
136EPHB20.38472774
137MAPK80.37525568
138NEK60.36595385
139ERBB20.35017249
140ERBB40.33813137
141EIF2AK10.33406685
142PIM10.32002027

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.66382313
2RNA transport_Homo sapiens_hsa030133.41407488
3Mismatch repair_Homo sapiens_hsa034303.23633342
4Spliceosome_Homo sapiens_hsa030403.22437488
5mRNA surveillance pathway_Homo sapiens_hsa030152.95610276
6Fanconi anemia pathway_Homo sapiens_hsa034602.83073287
7Cell cycle_Homo sapiens_hsa041102.81997554
8DNA replication_Homo sapiens_hsa030302.73220978
9Basal transcription factors_Homo sapiens_hsa030222.65973030
10RNA polymerase_Homo sapiens_hsa030202.59324349
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.35723850
12Homologous recombination_Homo sapiens_hsa034402.35493385
13Steroid biosynthesis_Homo sapiens_hsa001002.29048572
14Nucleotide excision repair_Homo sapiens_hsa034202.28893073
15Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.15039814
16Non-homologous end-joining_Homo sapiens_hsa034502.13987867
17Basal cell carcinoma_Homo sapiens_hsa052172.13019267
18One carbon pool by folate_Homo sapiens_hsa006702.11686346
19Base excision repair_Homo sapiens_hsa034102.10372796
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.05165257
21RNA degradation_Homo sapiens_hsa030181.94895072
22Hippo signaling pathway_Homo sapiens_hsa043901.81070282
23Hedgehog signaling pathway_Homo sapiens_hsa043401.71148031
24Oocyte meiosis_Homo sapiens_hsa041141.66817260
25Nicotine addiction_Homo sapiens_hsa050331.64900805
26p53 signaling pathway_Homo sapiens_hsa041151.61900392
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54185835
28Systemic lupus erythematosus_Homo sapiens_hsa053221.50187924
29Phototransduction_Homo sapiens_hsa047441.47572411
30Notch signaling pathway_Homo sapiens_hsa043301.43945759
31MicroRNAs in cancer_Homo sapiens_hsa052061.41230757
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37479969
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35136383
34Pyrimidine metabolism_Homo sapiens_hsa002401.32509020
35TGF-beta signaling pathway_Homo sapiens_hsa043501.31426367
36Wnt signaling pathway_Homo sapiens_hsa043101.28655405
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27291901
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21863048
39Adherens junction_Homo sapiens_hsa045201.21339288
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20813684
41Alcoholism_Homo sapiens_hsa050341.14395572
42Colorectal cancer_Homo sapiens_hsa052101.11545432
43Viral carcinogenesis_Homo sapiens_hsa052031.10184372
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09794614
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08044612
46Propanoate metabolism_Homo sapiens_hsa006401.02551024
47Tight junction_Homo sapiens_hsa045301.02334465
48Epstein-Barr virus infection_Homo sapiens_hsa051691.00057197
49Cocaine addiction_Homo sapiens_hsa050300.94115946
50Purine metabolism_Homo sapiens_hsa002300.92644542
51Endometrial cancer_Homo sapiens_hsa052130.92091481
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90562761
53HTLV-I infection_Homo sapiens_hsa051660.88980397
54Thyroid cancer_Homo sapiens_hsa052160.88444889
55Lysine degradation_Homo sapiens_hsa003100.88318640
56mTOR signaling pathway_Homo sapiens_hsa041500.87364783
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85320295
58Taste transduction_Homo sapiens_hsa047420.84249679
59Axon guidance_Homo sapiens_hsa043600.82449507
60Pathways in cancer_Homo sapiens_hsa052000.81327410
61Dopaminergic synapse_Homo sapiens_hsa047280.81288583
62Ribosome_Homo sapiens_hsa030100.77095402
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.76959312
64Protein export_Homo sapiens_hsa030600.74396626
65Long-term depression_Homo sapiens_hsa047300.73397953
66Small cell lung cancer_Homo sapiens_hsa052220.71848839
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71783611
68Selenocompound metabolism_Homo sapiens_hsa004500.71354831
69Proteasome_Homo sapiens_hsa030500.71186075
70Prostate cancer_Homo sapiens_hsa052150.67639035
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67333053
72Glutamatergic synapse_Homo sapiens_hsa047240.67175974
73Herpes simplex infection_Homo sapiens_hsa051680.63762028
74GABAergic synapse_Homo sapiens_hsa047270.61848742
75Dorso-ventral axis formation_Homo sapiens_hsa043200.61087652
76Melanoma_Homo sapiens_hsa052180.60330417
77Butanoate metabolism_Homo sapiens_hsa006500.58589676
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56439706
79Melanogenesis_Homo sapiens_hsa049160.54318127
80Bladder cancer_Homo sapiens_hsa052190.53114858
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52709947
82Proteoglycans in cancer_Homo sapiens_hsa052050.52431154
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52359347
84ErbB signaling pathway_Homo sapiens_hsa040120.50186015
85Type II diabetes mellitus_Homo sapiens_hsa049300.49549248
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49101346
87Chronic myeloid leukemia_Homo sapiens_hsa052200.48147296
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45585483
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44040197
90FoxO signaling pathway_Homo sapiens_hsa040680.43840004
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43368508
92Dilated cardiomyopathy_Homo sapiens_hsa054140.43141310
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43065272
94Prolactin signaling pathway_Homo sapiens_hsa049170.42028530
95Fatty acid metabolism_Homo sapiens_hsa012120.42011813
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41737073
97Circadian rhythm_Homo sapiens_hsa047100.40341803
98Renal cell carcinoma_Homo sapiens_hsa052110.40049916
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39959955
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37537274
101Vitamin B6 metabolism_Homo sapiens_hsa007500.37158132
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34276052
103Non-small cell lung cancer_Homo sapiens_hsa052230.33793911
104ECM-receptor interaction_Homo sapiens_hsa045120.33663243
105Biosynthesis of amino acids_Homo sapiens_hsa012300.33447611
106AMPK signaling pathway_Homo sapiens_hsa041520.33011843
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31692941
108Glucagon signaling pathway_Homo sapiens_hsa049220.31170966
109Inositol phosphate metabolism_Homo sapiens_hsa005620.29927820
110Choline metabolism in cancer_Homo sapiens_hsa052310.28398693
111Estrogen signaling pathway_Homo sapiens_hsa049150.26806910
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26660189
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26017976
114Rap1 signaling pathway_Homo sapiens_hsa040150.25880795
115HIF-1 signaling pathway_Homo sapiens_hsa040660.25431633
116Focal adhesion_Homo sapiens_hsa045100.24442626
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.23428048
118Gap junction_Homo sapiens_hsa045400.23073964
119MAPK signaling pathway_Homo sapiens_hsa040100.21233650
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20015956
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19609123
122Glioma_Homo sapiens_hsa052140.19561624
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18822831
124Linoleic acid metabolism_Homo sapiens_hsa005910.17143132
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.15942623
126Antigen processing and presentation_Homo sapiens_hsa046120.15844684
127Acute myeloid leukemia_Homo sapiens_hsa052210.15802643
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14574943
129Viral myocarditis_Homo sapiens_hsa054160.13904003
130Ras signaling pathway_Homo sapiens_hsa040140.13870546

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