KDM5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)5.60029537
2establishment of protein localization to Golgi (GO:0072600)4.85037477
3regulation of B cell receptor signaling pathway (GO:0050855)4.79550267
4nuclear pore complex assembly (GO:0051292)4.62162007
5protein targeting to Golgi (GO:0000042)4.57561851
6retrograde transport, vesicle recycling within Golgi (GO:0000301)4.48619935
7nuclear pore organization (GO:0006999)4.24404423
8mitotic sister chromatid cohesion (GO:0007064)4.17629485
9positive regulation of granulocyte differentiation (GO:0030854)3.66540700
10regulation of DNA endoreduplication (GO:0032875)3.65562436
11pore complex assembly (GO:0046931)3.59527286
12protein K48-linked deubiquitination (GO:0071108)3.59194343
13protein K11-linked deubiquitination (GO:0035871)3.57281833
14activated T cell proliferation (GO:0050798)3.44308163
15histone mRNA catabolic process (GO:0071044)3.43367389
16histone H3-K9 methylation (GO:0051567)3.39338254
17positive regulation of gamma-delta T cell activation (GO:0046645)3.34804838
18kinetochore organization (GO:0051383)3.33955666
19cellular extravasation (GO:0045123)3.33528875
20cellular response to ethanol (GO:0071361)3.26348398
21histone H3-K4 trimethylation (GO:0080182)3.26273140
22meiotic chromosome segregation (GO:0045132)3.24323803
23regulation of histone H3-K9 methylation (GO:0051570)3.20648939
24protein K63-linked deubiquitination (GO:0070536)3.19813389
25sister chromatid cohesion (GO:0007062)3.18535106
26protein localization to Golgi apparatus (GO:0034067)3.18125561
27early endosome to late endosome transport (GO:0045022)3.16723603
28monoubiquitinated protein deubiquitination (GO:0035520)3.13993588
29positive regulation of developmental pigmentation (GO:0048087)3.11496618
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.08468265
31negative regulation of cell killing (GO:0031342)3.08468265
32B cell receptor signaling pathway (GO:0050853)3.08025477
33negative regulation of DNA-dependent DNA replication (GO:2000104)3.06294617
34microtubule anchoring (GO:0034453)3.06144676
35microtubule nucleation (GO:0007020)3.05988638
36hepatocyte apoptotic process (GO:0097284)3.04568661
37dosage compensation (GO:0007549)3.04109139
38neutrophil mediated immunity (GO:0002446)3.03791767
39microglial cell activation (GO:0001774)3.02181913
40positive regulation of histone H3-K4 methylation (GO:0051571)3.01932893
41centrosome localization (GO:0051642)3.01282851
42cell wall macromolecule metabolic process (GO:0044036)3.00861943
43histone H3-K9 modification (GO:0061647)3.00761102
44cell wall macromolecule catabolic process (GO:0016998)2.94007318
45DNA synthesis involved in DNA repair (GO:0000731)2.92185747
46histone H3-K36 demethylation (GO:0070544)2.90670083
47peptidyl-lysine trimethylation (GO:0018023)2.90670031
48regulation of RNA export from nucleus (GO:0046831)2.85870685
49myeloid leukocyte mediated immunity (GO:0002444)2.85185372
50negative regulation of translation, ncRNA-mediated (GO:0040033)2.84696615
51regulation of translation, ncRNA-mediated (GO:0045974)2.84696615
52negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.84696615
53regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.84616706
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.84562871
55negative regulation of histone methylation (GO:0031061)2.83950179
56detection of molecule of bacterial origin (GO:0032490)2.75794448
57V(D)J recombination (GO:0033151)2.72932021
58snRNA transcription (GO:0009301)2.70819596
59DNA topological change (GO:0006265)2.70025491
60kinetochore assembly (GO:0051382)2.69420440
61response to interleukin-15 (GO:0070672)2.68923486
62cellular response to interleukin-15 (GO:0071350)2.68660049
63mitotic chromosome condensation (GO:0007076)2.64716517
64definitive hemopoiesis (GO:0060216)2.64580144
65centriole replication (GO:0007099)2.63268383
66positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.62209735
67negative T cell selection (GO:0043383)2.61696887
68regulation of B cell differentiation (GO:0045577)2.61139986
69replicative senescence (GO:0090399)2.60536032
70regulation of establishment of cell polarity (GO:2000114)2.60285585
71positive thymic T cell selection (GO:0045059)2.58724809
72positive T cell selection (GO:0043368)2.58328239
73poly(A)+ mRNA export from nucleus (GO:0016973)2.57968611
74negative regulation of neurotransmitter secretion (GO:0046929)2.57735859
75translesion synthesis (GO:0019985)2.57480444
76cytoplasmic mRNA processing body assembly (GO:0033962)2.57467458
77regulation of granulocyte differentiation (GO:0030852)2.57446838
78regulation of centriole replication (GO:0046599)2.57227001
79regulation of pigment cell differentiation (GO:0050932)2.57100143
80protein targeting to lysosome (GO:0006622)2.56879012
81establishment of protein localization to vacuole (GO:0072666)2.56879012
82protein targeting to vacuole (GO:0006623)2.56879012
83interkinetic nuclear migration (GO:0022027)2.55299477
84DNA alkylation (GO:0006305)2.54437636
85DNA methylation (GO:0006306)2.54437636
86regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.53942082
87intra-Golgi vesicle-mediated transport (GO:0006891)2.52155621
88nucleus localization (GO:0051647)2.51184257
89regulation of histone H3-K4 methylation (GO:0051569)2.51184148
90Golgi to endosome transport (GO:0006895)2.50732526
91histone H3-K4 methylation (GO:0051568)2.50709305
92regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.50210352
93regulation of histone methylation (GO:0031060)2.49665652
94regulation of nuclear cell cycle DNA replication (GO:0033262)2.49017565
95regulation of MHC class I biosynthetic process (GO:0045343)2.48832307
96histone H2A acetylation (GO:0043968)2.48809555
97mRNA splice site selection (GO:0006376)2.48076002
98negative regulation of T cell mediated immunity (GO:0002710)2.47251313
99regulation of meiosis I (GO:0060631)2.46952915
100establishment of nucleus localization (GO:0040023)2.46887354
101histone lysine demethylation (GO:0070076)2.45876186
102histone demethylation (GO:0016577)2.45233660
103positive regulation of cell cycle checkpoint (GO:1901978)2.43897438
104negative regulation of neurotransmitter transport (GO:0051589)2.43593257
105positive regulation of protein homooligomerization (GO:0032464)2.43297755
106positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.42657642
107embryonic hemopoiesis (GO:0035162)2.42492554
108regulation of gamma-delta T cell activation (GO:0046643)2.41968487
109positive regulation of interferon-beta production (GO:0032728)2.41196276
110protein demethylation (GO:0006482)2.41068020
111protein dealkylation (GO:0008214)2.41068020
112phospholipid translocation (GO:0045332)2.40968165
113lipid translocation (GO:0034204)2.40968165
114regulation of mRNA catabolic process (GO:0061013)2.40947234
115gene silencing by RNA (GO:0031047)2.39980633
116pyrimidine dimer repair (GO:0006290)2.39261257
117piRNA metabolic process (GO:0034587)2.39179272
118positive regulation of histone methylation (GO:0031062)2.38565417
119macrophage activation involved in immune response (GO:0002281)2.38288530
120T cell migration (GO:0072678)2.37617970
121DNA geometric change (GO:0032392)2.37151465
122regulation of protein polyubiquitination (GO:1902914)2.36945256
123DNA duplex unwinding (GO:0032508)2.35455885
124negative thymic T cell selection (GO:0045060)2.35401516
125intra-S DNA damage checkpoint (GO:0031573)2.34932851
126interferon-gamma production (GO:0032609)2.34436503
127DNA methylation involved in gamete generation (GO:0043046)2.31953887
128histone lysine methylation (GO:0034968)2.31613829
129positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.31542812
130positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.31542812
131positive regulation of mitotic sister chromatid separation (GO:1901970)2.31542812
132antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.31352631
133regulation of gamma-delta T cell differentiation (GO:0045586)2.30979287
134nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.30554295
135mitotic nuclear envelope disassembly (GO:0007077)2.30510142
136reciprocal meiotic recombination (GO:0007131)2.28930198
137reciprocal DNA recombination (GO:0035825)2.28930198
138neural tube formation (GO:0001841)2.28497808
139mRNA export from nucleus (GO:0006406)2.26154111
140synaptonemal complex assembly (GO:0007130)2.26139113
141resolution of meiotic recombination intermediates (GO:0000712)2.25701969
142chromosome organization involved in meiosis (GO:0070192)2.23765532
143protein K6-linked ubiquitination (GO:0085020)2.23197996
144positive regulation by host of viral transcription (GO:0043923)2.22697876
145negative regulation of DNA repair (GO:0045738)2.22601523
146mitotic recombination (GO:0006312)2.21594868
147negative regulation of B cell proliferation (GO:0030889)2.21222778
148N-terminal protein amino acid acetylation (GO:0006474)2.19310879
149regulation of fibroblast apoptotic process (GO:2000269)2.19266357
150spindle checkpoint (GO:0031577)2.19201341
151somatic cell DNA recombination (GO:0016444)2.18757004
152somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.18757004
153mismatch repair (GO:0006298)2.17840358
154pre-miRNA processing (GO:0031054)2.17727865
155DNA methylation or demethylation (GO:0044728)2.17601501
156telomere maintenance (GO:0000723)2.17374201
157replication fork processing (GO:0031297)2.17238652
158histone mRNA metabolic process (GO:0008334)2.16877721
159centriole assembly (GO:0098534)2.16621664
160T cell selection (GO:0045058)2.15886249
161postreplication repair (GO:0006301)2.15760250
162peptidyl-lysine methylation (GO:0018022)2.15398925
163histone H3-K9 demethylation (GO:0033169)2.15049327

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.18838016
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.78855556
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.44668145
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.37258929
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.29100978
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.01146433
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.97796429
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.92757401
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.90269292
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.90192060
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.87401557
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.87233489
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.26338329
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25768379
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21523505
16* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19300251
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03956096
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03123737
19ELK1_19687146_ChIP-ChIP_HELA_Human2.02854623
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.00288154
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99588706
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.99168305
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.98390277
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96352766
25TAF15_26573619_Chip-Seq_HEK293_Human1.90942403
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87725988
27GBX2_23144817_ChIP-Seq_PC3_Human1.85404350
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.80009623
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78678005
30ZNF274_21170338_ChIP-Seq_K562_Hela1.78111520
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.76157370
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74709919
33IGF1R_20145208_ChIP-Seq_DFB_Human1.72276382
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.72009329
35TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72009329
36STAT3_23295773_ChIP-Seq_U87_Human1.70377467
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67397029
38P300_19829295_ChIP-Seq_ESCs_Human1.64028571
39TP53_16413492_ChIP-PET_HCT116_Human1.60763210
40SMAD4_21799915_ChIP-Seq_A2780_Human1.59759586
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59709360
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57449847
43ER_23166858_ChIP-Seq_MCF-7_Human1.55019213
44AR_21572438_ChIP-Seq_LNCaP_Human1.53891744
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50157372
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49829517
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49823312
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47637188
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.46620682
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46169071
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46078064
52CBP_20019798_ChIP-Seq_JUKART_Human1.46078064
53MYB_26560356_Chip-Seq_TH2_Human1.45961071
54VDR_23849224_ChIP-Seq_CD4+_Human1.45705722
55* TCF4_23295773_ChIP-Seq_U87_Human1.45053543
56RUNX_20019798_ChIP-Seq_JUKART_Human1.44047232
57MYB_26560356_Chip-Seq_TH1_Human1.43900643
58* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43009876
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41152083
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40839815
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38981675
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38496076
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37172289
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36530037
65CIITA_25753668_ChIP-Seq_RAJI_Human1.36197669
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36181401
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35845321
68* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34882865
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34268421
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.32508482
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32332402
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.31856659
73GATA1_22025678_ChIP-Seq_K562_Human1.31674801
74EWS_26573619_Chip-Seq_HEK293_Human1.31594459
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29489462
76BCAT_22108803_ChIP-Seq_LS180_Human1.28851093
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27410803
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26760724
79VDR_24787735_ChIP-Seq_THP-1_Human1.26685140
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.26495998
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25716468
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.25572263
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25290987
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.25244217
85SCL_19346495_ChIP-Seq_HPC-7_Human1.22941265
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22194912
87AR_25329375_ChIP-Seq_VCAP_Human1.21025452
88VDR_22108803_ChIP-Seq_LS180_Human1.20582626
89GATA3_26560356_Chip-Seq_TH2_Human1.20027742
90AHR_22903824_ChIP-Seq_MCF-7_Human1.19686597
91STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18391261
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17643404
93FUS_26573619_Chip-Seq_HEK293_Human1.16807086
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16152032
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16096421
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15713534
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15392989
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15201246
99EST1_17652178_ChIP-ChIP_JURKAT_Human1.14717264
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.13639500
101MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13562143
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13405072
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12976547
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12616936
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12147235
106ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12042974
107MYC_22102868_ChIP-Seq_BL_Human1.11467192
108SMAD_19615063_ChIP-ChIP_OVARY_Human1.10360430
109PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09928785
110TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09530304
111WT1_19549856_ChIP-ChIP_CCG9911_Human1.09360015
112PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08957449
113PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08463109
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07460685
115AR_21909140_ChIP-Seq_LNCAP_Human1.07015518
116* FOXP3_21729870_ChIP-Seq_TREG_Human1.06983209
117TCF4_22108803_ChIP-Seq_LS180_Human1.06745870
118P53_22387025_ChIP-Seq_ESCs_Mouse1.06560556
119SMRT_27268052_Chip-Seq_Bcells_Human1.06175492
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05972468
121* RUNX2_22187159_ChIP-Seq_PCA_Human1.05164072
122MYC_18555785_ChIP-Seq_MESCs_Mouse1.05071446
123* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04323519
124FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04261626
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03566795
126BRD4_25478319_ChIP-Seq_HGPS_Human1.03560647
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02595206
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02587702
129CMYC_18555785_Chip-Seq_ESCs_Mouse1.01868709
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.01782849
131SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01469315
132* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01008924
133* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99887119
134MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99716370
135SPI1_23547873_ChIP-Seq_NB4_Human0.98523398
136IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97875008
137MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97568468
138GATA3_27048872_Chip-Seq_THYMUS_Human0.96345396
139SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96297199
140NFE2_27457419_Chip-Seq_LIVER_Mouse0.95663619
141SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94455437
142SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94455437
143IRF8_21731497_ChIP-ChIP_J774_Mouse0.92708943
144* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92232023
145KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.91159786
146SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87387506
147SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87361932
148IRF8_27001747_Chip-Seq_BMDM_Mouse0.86396656
149CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84544992
150EZH2_27294783_Chip-Seq_NPCs_Mouse0.81692801
151TFEB_21752829_ChIP-Seq_HELA_Human0.81618867
152GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80830513
153* KDM5A_27292631_Chip-Seq_BREAST_Human0.79696527
154MAF_26560356_Chip-Seq_TH1_Human0.79314311
155UTX_26944678_Chip-Seq_JUKART_Human0.78981440
156NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.78923588
157CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.78906527
158GABP_17652178_ChIP-ChIP_JURKAT_Human0.78692070
159NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78094624
160PU_27001747_Chip-Seq_BMDM_Mouse0.77691622
161E2F1_18555785_Chip-Seq_ESCs_Mouse0.76880298
162TCF4_18268006_ChIP-ChIP_LS174T_Human0.75930974

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.58696425
2MP0008877_abnormal_DNA_methylation3.37878322
3MP0008058_abnormal_DNA_repair2.82510418
4MP0010094_abnormal_chromosome_stability2.56323187
5MP0003787_abnormal_imprinting2.51939253
6MP0002009_preneoplasia2.45437521
7MP0008007_abnormal_cellular_replicative2.37145051
8MP0003763_abnormal_thymus_physiology2.29926502
9* MP0003077_abnormal_cell_cycle2.12093861
10MP0003121_genomic_imprinting2.08943366
11MP0004381_abnormal_hair_follicle2.07001809
12MP0003941_abnormal_skin_development1.96829917
13MP0003693_abnormal_embryo_hatching1.94389379
14MP0002396_abnormal_hematopoietic_system1.93056054
15MP0002166_altered_tumor_susceptibility1.91803616
16MP0003111_abnormal_nucleus_morphology1.90526428
17MP0010352_gastrointestinal_tract_polyps1.84637295
18* MP0004808_abnormal_hematopoietic_stem1.81149714
19MP0003724_increased_susceptibility_to1.72984783
20MP0003656_abnormal_erythrocyte_physiolo1.70674936
21MP0005171_absent_coat_pigmentation1.68056841
22MP0002006_tumorigenesis1.63902497
23MP0001835_abnormal_antigen_presentation1.62197754
24MP0000569_abnormal_digit_pigmentation1.61051564
25MP0005671_abnormal_response_to1.57894277
26MP0000703_abnormal_thymus_morphology1.55215571
27MP0005310_abnormal_salivary_gland1.54004777
28MP0003786_premature_aging1.51255382
29MP0004142_abnormal_muscle_tone1.48044641
30MP0000371_diluted_coat_color1.45759053
31MP0000383_abnormal_hair_follicle1.43750307
32MP0004957_abnormal_blastocyst_morpholog1.42671859
33MP0008961_abnormal_basal_metabolism1.39154463
34MP0002398_abnormal_bone_marrow1.37501551
35MP0002095_abnormal_skin_pigmentation1.36994977
36MP0002928_abnormal_bile_duct1.34599567
37MP0002938_white_spotting1.34488498
38MP0003828_pulmonary_edema1.34122654
39MP0001800_abnormal_humoral_immune1.33414119
40MP0010307_abnormal_tumor_latency1.31023735
41MP0005409_darkened_coat_color1.30799685
42MP0001293_anophthalmia1.29844075
43MP0000350_abnormal_cell_proliferation1.28115451
44MP0003045_fibrosis1.27394881
45MP0008995_early_reproductive_senescence1.26299683
46MP0005174_abnormal_tail_pigmentation1.20162090
47MP0003303_peritoneal_inflammation1.17163987
48MP0001853_heart_inflammation1.16995584
49MP0002452_abnormal_antigen_presenting1.15714320
50MP0003890_abnormal_embryonic-extraembry1.15620855
51MP0003123_paternal_imprinting1.14917411
52MP0005076_abnormal_cell_differentiation1.14132343
53MP0004883_abnormal_blood_vessel1.13382657
54MP0010678_abnormal_skin_adnexa1.12100037
55MP0003943_abnormal_hepatobiliary_system1.11383455
56MP0000015_abnormal_ear_pigmentation1.11214245
57MP0002102_abnormal_ear_morphology1.11151357
58MP0002420_abnormal_adaptive_immunity1.11148026
59MP0001790_abnormal_immune_system1.10086340
60MP0005387_immune_system_phenotype1.10086340
61MP0001819_abnormal_immune_cell1.09417584
62MP0004197_abnormal_fetal_growth/weight/1.07683348
63* MP0000716_abnormal_immune_system1.07376113
64MP0008932_abnormal_embryonic_tissue1.07242262
65MP0002722_abnormal_immune_system1.07107609
66MP0002210_abnormal_sex_determination1.06409558
67MP0000689_abnormal_spleen_morphology1.04446570
68MP0001919_abnormal_reproductive_system1.03612416
69MP0003567_abnormal_fetal_cardiomyocyte1.03140531
70MP0005380_embryogenesis_phenotype1.01758898
71MP0001672_abnormal_embryogenesis/_devel1.01758898
72MP0003136_yellow_coat_color1.01115489
73MP0006054_spinal_hemorrhage1.00507396
74MP0003984_embryonic_growth_retardation1.00163652
75MP0002723_abnormal_immune_serum0.99749823
76MP0002088_abnormal_embryonic_growth/wei0.99199286
77MP0002405_respiratory_system_inflammati0.98239484
78MP0000685_abnormal_immune_system0.97438201
79MP0002638_abnormal_pupillary_reflex0.97235898
80MP0000432_abnormal_head_morphology0.96486136
81MP0005397_hematopoietic_system_phenotyp0.95997072
82MP0001545_abnormal_hematopoietic_system0.95997072
83MP0002933_joint_inflammation0.94993639
84MP0009703_decreased_birth_body0.93705391
85MP0002168_other_aberrant_phenotype0.93126283
86MP0004484_altered_response_of0.93087470
87MP0002419_abnormal_innate_immunity0.92812238
88MP0001188_hyperpigmentation0.91197642
89MP0003172_abnormal_lysosome_physiology0.90474375
90MP0010155_abnormal_intestine_physiology0.89778466
91MP0000490_abnormal_crypts_of0.89186023
92* MP0002429_abnormal_blood_cell0.88731441
93MP0002019_abnormal_tumor_incidence0.88540755
94MP0003300_gastrointestinal_ulcer0.88050273
95MP0002075_abnormal_coat/hair_pigmentati0.87880565
96MP0005000_abnormal_immune_tolerance0.87466885
97MP0006292_abnormal_olfactory_placode0.87122844
98MP0001324_abnormal_eye_pigmentation0.87111528
99MP0000372_irregular_coat_pigmentation0.87046045
100MP0002086_abnormal_extraembryonic_tissu0.86975777
101MP0001929_abnormal_gametogenesis0.86825786
102MP0004134_abnormal_chest_morphology0.86795169
103MP0001879_abnormal_lymphatic_vessel0.85332195
104MP0003937_abnormal_limbs/digits/tail_de0.85214498
105MP0003935_abnormal_craniofacial_develop0.84086030
106MP0001730_embryonic_growth_arrest0.83402745
107MP0002138_abnormal_hepatobiliary_system0.83358833
108MP0001286_abnormal_eye_development0.82831888
109MP0001697_abnormal_embryo_size0.82276652
110MP0001186_pigmentation_phenotype0.82123366
111MP0002084_abnormal_developmental_patter0.82001340
112MP0005025_abnormal_response_to0.81474935
113MP0001145_abnormal_male_reproductive0.80782294
114MP0005253_abnormal_eye_physiology0.80660441
115MP0003091_abnormal_cell_migration0.80393800
116MP0003183_abnormal_peptide_metabolism0.80024981
117MP0000427_abnormal_hair_cycle0.79920185
118MP0002085_abnormal_embryonic_tissue0.79738019
119MP0000428_abnormal_craniofacial_morphol0.79446031
120MP0001915_intracranial_hemorrhage0.79310167
121MP0000313_abnormal_cell_death0.79280025
122MP0001873_stomach_inflammation0.78854380
123MP0000566_synostosis0.78231488
124MP0000516_abnormal_urinary_system0.77307159
125MP0005367_renal/urinary_system_phenotyp0.77307159
126MP0005075_abnormal_melanosome_morpholog0.77293800
127MP0005551_abnormal_eye_electrophysiolog0.76324498
128MP0009115_abnormal_fat_cell0.75669727
129MP0000778_abnormal_nervous_system0.75073314
130MP0003698_abnormal_male_reproductive0.72952963
131MP0001986_abnormal_taste_sensitivity0.71304534
132MP0002163_abnormal_gland_morphology0.71215410
133MP0005408_hypopigmentation0.70940555
134MP0005389_reproductive_system_phenotype0.69389970
135MP0009785_altered_susceptibility_to0.68892662
136MP0005187_abnormal_penis_morphology0.66266442
137MP0003646_muscle_fatigue0.64184570
138MP0001119_abnormal_female_reproductive0.62859369
139MP0003866_abnormal_defecation0.62680605
140MP0002332_abnormal_exercise_endurance0.60854311
141MP0005410_abnormal_fertilization0.60174432
142MP0006072_abnormal_retinal_apoptosis0.59234227
143MP0003252_abnormal_bile_duct0.59006162
144MP0003221_abnormal_cardiomyocyte_apopto0.58738132
145MP0000465_gastrointestinal_hemorrhage0.56317592
146MP0005379_endocrine/exocrine_gland_phen0.55251778

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.90697746
2Volvulus (HP:0002580)3.67279767
3Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.44463820
4Chronic hepatic failure (HP:0100626)3.25699991
5Hyperventilation (HP:0002883)3.19009245
6T lymphocytopenia (HP:0005403)3.01559374
7Chromsome breakage (HP:0040012)2.99434534
8Widely spaced teeth (HP:0000687)2.83508303
9Abnormality of T cell number (HP:0011839)2.83331749
10Fair hair (HP:0002286)2.77180071
11Abnormal delayed hypersensitivity skin test (HP:0002963)2.74022286
12Abnormality of the nasal septum (HP:0000419)2.67362965
13Thyroiditis (HP:0100646)2.59322392
14Hypochromic microcytic anemia (HP:0004840)2.57908918
15Pancreatic cysts (HP:0001737)2.56423888
16Long eyelashes (HP:0000527)2.55229919
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.54874311
18Ectopic kidney (HP:0000086)2.54851826
19Abnormality of incisor morphology (HP:0011063)2.53925967
20Deep philtrum (HP:0002002)2.53542746
21Stomach cancer (HP:0012126)2.53419851
22Eosinophilia (HP:0001880)2.50522710
23Recurrent bacterial skin infections (HP:0005406)2.49135909
24Hip dysplasia (HP:0001385)2.46863380
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.45940692
26Short 4th metacarpal (HP:0010044)2.45940692
27Lip pit (HP:0100267)2.42860994
28Hypoplastic iliac wings (HP:0002866)2.42629034
29Generalized hypopigmentation of hair (HP:0011358)2.41594978
30Acute myeloid leukemia (HP:0004808)2.38743679
31Neoplasm of the tracheobronchial system (HP:0100552)2.38029316
32Recurrent cutaneous fungal infections (HP:0011370)2.37086620
33Chronic mucocutaneous candidiasis (HP:0002728)2.37086620
3411 pairs of ribs (HP:0000878)2.33237616
35Papillary thyroid carcinoma (HP:0002895)2.32439477
36Absent frontal sinuses (HP:0002688)2.28981383
37Absent speech (HP:0001344)2.27657109
38Pancreatic fibrosis (HP:0100732)2.27025796
39Granulocytopenia (HP:0001913)2.26493007
40B lymphocytopenia (HP:0010976)2.25084463
41Abnormality of B cell number (HP:0010975)2.25084463
42Severe combined immunodeficiency (HP:0004430)2.23925579
43Oligodactyly (hands) (HP:0001180)2.22259446
44Abnormality of the intervertebral disk (HP:0005108)2.22048010
45Abnormality of eosinophils (HP:0001879)2.18194807
46Abnormality of the renal cortex (HP:0011035)2.16692590
47Protruding tongue (HP:0010808)2.15967610
48Thyroid carcinoma (HP:0002890)2.15485366
49Abnormality of the incisor (HP:0000676)2.14397625
50Viral hepatitis (HP:0006562)2.14026168
51White forelock (HP:0002211)2.11630351
52Medulloblastoma (HP:0002885)2.10847520
53Gaze-evoked nystagmus (HP:0000640)2.05854485
54Abnormality of the parietal bone (HP:0002696)2.04851415
55Abnormality of the renal medulla (HP:0100957)2.04468876
56Recurrent viral infections (HP:0004429)2.04064397
57Retrobulbar optic neuritis (HP:0100654)2.03593719
58Optic neuritis (HP:0100653)2.03593719
59Supernumerary ribs (HP:0005815)2.03313515
60Large earlobe (HP:0009748)2.02705988
61Abnormality of chromosome stability (HP:0003220)2.02579221
62Abnormal hair whorl (HP:0010721)2.01109128
63Drooling (HP:0002307)1.99638942
64Genetic anticipation (HP:0003743)1.99246463
65Excessive salivation (HP:0003781)1.98078665
66Colon cancer (HP:0003003)1.95616365
67Supernumerary bones of the axial skeleton (HP:0009144)1.93527854
68Long clavicles (HP:0000890)1.92611243
69Neoplasm of the adrenal cortex (HP:0100641)1.92433930
70Lymphoma (HP:0002665)1.92131599
71Gastrointestinal infarctions (HP:0005244)1.92030058
72Abnormality of midbrain morphology (HP:0002418)1.91860472
73Molar tooth sign on MRI (HP:0002419)1.91860472
74IgM deficiency (HP:0002850)1.91678862
75Curly hair (HP:0002212)1.90738716
76Hypoplastic ischia (HP:0003175)1.89421210
77Thick eyebrow (HP:0000574)1.88404758
78Anal stenosis (HP:0002025)1.86608059
79Nephronophthisis (HP:0000090)1.85825186
80Alveolar cell carcinoma (HP:0006519)1.85297981
81Prostate neoplasm (HP:0100787)1.84890110
82Birth length less than 3rd percentile (HP:0003561)1.84685166
83Recurrent skin infections (HP:0001581)1.81902752
84Agammaglobulinemia (HP:0004432)1.81180205
85Trigonocephaly (HP:0000243)1.81031054
86Patchy hypopigmentation of hair (HP:0011365)1.80890308
87Tapered finger (HP:0001182)1.79565155
88Abnormality of the ischium (HP:0003174)1.79254930
89Deviation of the thumb (HP:0009603)1.79215997
90Truncal obesity (HP:0001956)1.78926564
91Persistence of primary teeth (HP:0006335)1.78830048
92Recurrent abscess formation (HP:0002722)1.78497411
93Abnormality of T cells (HP:0002843)1.78449644
94Tented upper lip vermilion (HP:0010804)1.78012348
95True hermaphroditism (HP:0010459)1.77748441
96Combined immunodeficiency (HP:0005387)1.77703953
97Hypoplastic labia majora (HP:0000059)1.76873753
98Albinism (HP:0001022)1.76546430
99Sandal gap (HP:0001852)1.76139623
100Poor coordination (HP:0002370)1.75119445
101Panhypogammaglobulinemia (HP:0003139)1.74647723
102Ectropion (HP:0000656)1.73845952
103Myelodysplasia (HP:0002863)1.73280764
104Lymphopenia (HP:0001888)1.73119191
105Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.71907561
106Heterotopia (HP:0002282)1.71681736
107Abnormality of the columella (HP:0009929)1.70313704
108Abnormal pancreas size (HP:0012094)1.69917586
109Attenuation of retinal blood vessels (HP:0007843)1.69669071
110IgG deficiency (HP:0004315)1.68981710
111Gingivitis (HP:0000230)1.68567122
112Syringomyelia (HP:0003396)1.68376553
113Spinal cord lesions (HP:0100561)1.68376553
114Hypoplasia of the thymus (HP:0000778)1.68156565
115Aplasia/Hypoplasia of the earlobes (HP:0009906)1.67907521
116Thickened calvaria (HP:0002684)1.67275845
117Keratitis (HP:0000491)1.67038531
118Proximal placement of thumb (HP:0009623)1.66996993
119Basal cell carcinoma (HP:0002671)1.66373209
120Hepatoblastoma (HP:0002884)1.66149752
121Cutis marmorata (HP:0000965)1.65424072
122Myositis (HP:0100614)1.64506502
123Abnormality of the frontal sinuses (HP:0002687)1.63968531
124Midline defect of the nose (HP:0004122)1.63794066
125Leukocytosis (HP:0001974)1.63779839
126Narrow palate (HP:0000189)1.63046552
127Highly arched eyebrow (HP:0002553)1.62808395
128Nephroblastoma (Wilms tumor) (HP:0002667)1.62563875
129Neoplasm of the oral cavity (HP:0100649)1.62480078
130Neonatal hypoglycemia (HP:0001998)1.62428242
131Colitis (HP:0002583)1.62145276
132Cupped ear (HP:0000378)1.62142459
133Diastasis recti (HP:0001540)1.61210163
134Renal cortical cysts (HP:0000803)1.60693815
135Recurrent fungal infections (HP:0002841)1.60279358
136Menstrual irregularities (HP:0000858)1.60189450
137Tubulointerstitial nephritis (HP:0001970)1.59168659
138Meckel diverticulum (HP:0002245)1.57855216
139Abnormality of cells of the lymphoid lineage (HP:0012140)1.57593644
140Low anterior hairline (HP:0000294)1.57445948
141Limited elbow extension (HP:0001377)1.57243651
142IgA deficiency (HP:0002720)1.56909070
143Recurrent bronchitis (HP:0002837)1.56532885
144Abnormality of the labia majora (HP:0012881)1.56439635
145Abnormal lung lobation (HP:0002101)1.56009201
146Impulsivity (HP:0100710)1.55698725
147Bell-shaped thorax (HP:0001591)1.55375136
148Prominent nose (HP:0000448)1.55205510
149Embryonal renal neoplasm (HP:0011794)1.55045580
150Chronic diarrhea (HP:0002028)1.54046344
151Dislocated radial head (HP:0003083)1.53698713
152Abnormality of DNA repair (HP:0003254)1.52478896
153Aplasia/Hypoplasia of the uvula (HP:0010293)1.51965723
154Convex nasal ridge (HP:0000444)1.51623493
155Patellar aplasia (HP:0006443)1.51107323
156Optic nerve coloboma (HP:0000588)1.50752154
157Subacute progressive viral hepatitis (HP:0006572)1.48084081
158Hematochezia (HP:0002573)1.47622560
159Abnormality of the ileum (HP:0001549)1.47577356
160Facial cleft (HP:0002006)1.47055133
161Synophrys (HP:0000664)1.46876499
162Hypoplasia of the maxilla (HP:0000327)1.46642460
163Abnormality of the distal phalanx of the thumb (HP:0009617)1.46421002
164Broad thumb (HP:0011304)1.45830902
165Biliary tract neoplasm (HP:0100574)1.45630960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD43.15360394
2CDK122.99654555
3TXK2.78769762
4ZAK2.72650372
5TAOK32.63262297
6CDC72.62457671
7PLK42.52174865
8CASK2.43145081
9SRPK12.35520475
10ERBB32.18879175
11MKNK22.06846351
12PIK3CG2.02445144
13MKNK12.02103926
14ACVR1B2.00771312
15NUAK11.98505858
16MAP3K141.97749406
17MAP4K11.81603429
18STK241.73327747
19MAP3K41.72199504
20ATR1.65488477
21CHUK1.63475838
22AKT31.56820584
23NLK1.56126792
24FGFR31.46038051
25STK31.43888971
26WNK11.43817094
27TEC1.43559003
28BLK1.42915600
29STK41.42503093
30PNCK1.41455883
31YES11.37477146
32IRAK41.33789072
33TNIK1.30927229
34JAK31.30875200
35CAMKK21.30118392
36CAMK1D1.28640539
37TSSK61.26982489
38PLK31.23040646
39ATM1.22854973
40IRAK31.17517821
41ITK1.16620246
42SGK21.15047427
43CDK91.13008326
44CLK11.10385792
45EPHA31.10309885
46RAF11.09213135
47STK101.08876683
48IKBKB1.08127365
49EIF2AK21.06263373
50WNK31.05059654
51MAPK131.04892976
52SYK1.04721516
53RPS6KA41.04524578
54TRPM71.03933665
55NEK61.03211063
56PIM11.01758999
57VRK11.00459840
58NEK21.00454646
59JAK11.00412470
60SGK2230.99010416
61SGK4940.99010416
62CHEK10.98996925
63PLK20.98449745
64RPS6KA50.96424520
65FES0.96188817
66IKBKE0.95691564
67EIF2AK30.93221726
68PTK2B0.91746977
69PASK0.91284418
70CAMK1G0.88475613
71BTK0.87290924
72LATS10.87122405
73INSRR0.86178623
74MELK0.84847392
75MAPK70.83672467
76PAK30.83149259
77TYK20.82838082
78CHEK20.81906519
79GRK60.79561876
80STK38L0.78913101
81TLK10.78055760
82PRKCQ0.77841992
83SGK10.77774455
84SGK30.77265772
85CDK70.77039823
86AURKB0.76233198
87MARK20.75472126
88DMPK0.75038828
89MAP3K20.74957778
90MST40.74881038
91FGFR20.74800271
92RIPK40.73709880
93DYRK1A0.73652267
94RPS6KB20.73614058
95SIK30.73599261
96WEE10.73325572
97CDK60.73138131
98TTK0.72901767
99PDGFRB0.72071716
100FGR0.71707526
101BMPR20.71669086
102CSF1R0.71172755
103PLK10.71051449
104LCK0.70517179
105BRSK20.68191589
106MAP4K20.66870638
107CSK0.66275559
108TGFBR10.65218613
109HCK0.64671857
110EPHB10.64378837
111CDK30.64125588
112STK390.61420128
113* CDK20.60978878
114DYRK30.59554103
115BMPR1B0.59174380
116IRAK10.59151761
117FRK0.58711105
118CAMK40.58017804
119RPS6KB10.56406219
120* CDK10.56186687
121HIPK20.56006319
122MTOR0.55551870
123CDK40.54318594
124STK110.53030497
125KSR10.52486880
126MAP3K60.51562627
127PRKDC0.51217551
128OXSR10.50316221
129NTRK20.49231637
130TNK20.49213688
131MAP3K100.48762679
132STK160.48480074
133SIK20.47582694
134JAK20.47291602
135ERBB20.46119373
136* MAPK140.45330973
137NEK90.45020414
138MARK30.44648398
139PIK3CA0.44575631
140BCR0.43377710
141ZAP700.42624570
142LYN0.42440427

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034502.92552848
2Primary immunodeficiency_Homo sapiens_hsa053402.38171002
3Fanconi anemia pathway_Homo sapiens_hsa034602.30808029
4Dorso-ventral axis formation_Homo sapiens_hsa043202.15936096
5Mismatch repair_Homo sapiens_hsa034302.14748452
6Homologous recombination_Homo sapiens_hsa034402.09213956
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06055601
8Cell cycle_Homo sapiens_hsa041102.00704285
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.90964303
10Basal transcription factors_Homo sapiens_hsa030221.85396644
11Spliceosome_Homo sapiens_hsa030401.85260763
12DNA replication_Homo sapiens_hsa030301.78895820
13RNA degradation_Homo sapiens_hsa030181.77118684
14RNA transport_Homo sapiens_hsa030131.63561675
15mRNA surveillance pathway_Homo sapiens_hsa030151.63210345
16Herpes simplex infection_Homo sapiens_hsa051681.59387857
17Measles_Homo sapiens_hsa051621.58060088
18Base excision repair_Homo sapiens_hsa034101.53871604
19Nucleotide excision repair_Homo sapiens_hsa034201.52908872
20Inositol phosphate metabolism_Homo sapiens_hsa005621.46644871
21Transcriptional misregulation in cancer_Homo sapiens_hsa052021.45135055
22Phosphatidylinositol signaling system_Homo sapiens_hsa040701.45113638
23T cell receptor signaling pathway_Homo sapiens_hsa046601.45048863
24p53 signaling pathway_Homo sapiens_hsa041151.42749490
25B cell receptor signaling pathway_Homo sapiens_hsa046621.41098078
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39058587
27Antigen processing and presentation_Homo sapiens_hsa046121.35333152
28MicroRNAs in cancer_Homo sapiens_hsa052061.33080010
29Viral carcinogenesis_Homo sapiens_hsa052031.32386419
30Small cell lung cancer_Homo sapiens_hsa052221.28289771
31Systemic lupus erythematosus_Homo sapiens_hsa053221.27988028
32Adherens junction_Homo sapiens_hsa045201.26077500
33Hematopoietic cell lineage_Homo sapiens_hsa046401.24003612
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.22825140
35Prostate cancer_Homo sapiens_hsa052151.21753200
36Epstein-Barr virus infection_Homo sapiens_hsa051691.20841858
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18609137
38HTLV-I infection_Homo sapiens_hsa051661.18540584
39Circadian rhythm_Homo sapiens_hsa047101.15374199
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13261610
41RNA polymerase_Homo sapiens_hsa030201.12674559
42Chronic myeloid leukemia_Homo sapiens_hsa052201.07834642
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05530241
44One carbon pool by folate_Homo sapiens_hsa006701.05347469
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.05226699
46Influenza A_Homo sapiens_hsa051641.04835903
47Lysine degradation_Homo sapiens_hsa003101.04684587
48Allograft rejection_Homo sapiens_hsa053301.04433797
49Hepatitis B_Homo sapiens_hsa051611.03287762
50Tuberculosis_Homo sapiens_hsa051521.02517932
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00087339
52Notch signaling pathway_Homo sapiens_hsa043300.98788231
53Staphylococcus aureus infection_Homo sapiens_hsa051500.96998742
54Osteoclast differentiation_Homo sapiens_hsa043800.96911002
55Leishmaniasis_Homo sapiens_hsa051400.95754253
56TGF-beta signaling pathway_Homo sapiens_hsa043500.94830095
57mTOR signaling pathway_Homo sapiens_hsa041500.94805883
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94752165
59FoxO signaling pathway_Homo sapiens_hsa040680.93717512
60Toxoplasmosis_Homo sapiens_hsa051450.93207786
61Type I diabetes mellitus_Homo sapiens_hsa049400.93205643
62TNF signaling pathway_Homo sapiens_hsa046680.91528136
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.90480581
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89076183
65Acute myeloid leukemia_Homo sapiens_hsa052210.88424308
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.88240610
67Autoimmune thyroid disease_Homo sapiens_hsa053200.87754504
68Colorectal cancer_Homo sapiens_hsa052100.86104852
69Pancreatic cancer_Homo sapiens_hsa052120.86011136
70Asthma_Homo sapiens_hsa053100.85964348
71ABC transporters_Homo sapiens_hsa020100.85225687
72ErbB signaling pathway_Homo sapiens_hsa040120.85176939
73Graft-versus-host disease_Homo sapiens_hsa053320.84983421
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84554350
75Regulation of autophagy_Homo sapiens_hsa041400.83807262
76Viral myocarditis_Homo sapiens_hsa054160.82941289
77Choline metabolism in cancer_Homo sapiens_hsa052310.81933066
78Renal cell carcinoma_Homo sapiens_hsa052110.80829786
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80044948
80Apoptosis_Homo sapiens_hsa042100.79340109
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77933769
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76242879
83Pathways in cancer_Homo sapiens_hsa052000.75781015
84Type II diabetes mellitus_Homo sapiens_hsa049300.74801944
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74532750
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74425992
87Basal cell carcinoma_Homo sapiens_hsa052170.73662061
88Thyroid cancer_Homo sapiens_hsa052160.73539697
89Glioma_Homo sapiens_hsa052140.73417247
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72657287
91ECM-receptor interaction_Homo sapiens_hsa045120.72618214
92Endometrial cancer_Homo sapiens_hsa052130.70639511
93Hepatitis C_Homo sapiens_hsa051600.70107911
94Prolactin signaling pathway_Homo sapiens_hsa049170.67205968
95Caffeine metabolism_Homo sapiens_hsa002320.66862210
96Chemokine signaling pathway_Homo sapiens_hsa040620.66073658
97Selenocompound metabolism_Homo sapiens_hsa004500.65163287
98Wnt signaling pathway_Homo sapiens_hsa043100.63361788
99Long-term depression_Homo sapiens_hsa047300.62906465
100Hippo signaling pathway_Homo sapiens_hsa043900.62595933
101Cholinergic synapse_Homo sapiens_hsa047250.62480167
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62246381
103Pyrimidine metabolism_Homo sapiens_hsa002400.61944817
104MAPK signaling pathway_Homo sapiens_hsa040100.61751715
105Legionellosis_Homo sapiens_hsa051340.61626572
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61584488
107Focal adhesion_Homo sapiens_hsa045100.61364023
108VEGF signaling pathway_Homo sapiens_hsa043700.60909835
109Insulin resistance_Homo sapiens_hsa049310.60860431
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60811730
111Malaria_Homo sapiens_hsa051440.59273260
112Proteoglycans in cancer_Homo sapiens_hsa052050.59130875
113Non-small cell lung cancer_Homo sapiens_hsa052230.58348751
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57782974
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.57758877
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.57416645
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57042997
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56405137
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56028414
120Platelet activation_Homo sapiens_hsa046110.55803056
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55316329
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54309815
123Shigellosis_Homo sapiens_hsa051310.53605103
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51654279
125Alcoholism_Homo sapiens_hsa050340.51575133
126Melanoma_Homo sapiens_hsa052180.49447179
127Phototransduction_Homo sapiens_hsa047440.49217128
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48805213
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47968645
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46072086
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45954314

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