KDM4C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)6.13002206
2regulation of B cell receptor signaling pathway (GO:0050855)5.98798568
3rhodopsin mediated signaling pathway (GO:0016056)5.93432596
4retinal cone cell development (GO:0046549)5.88310773
5positive regulation of gamma-delta T cell activation (GO:0046645)5.74094260
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.56313776
7negative regulation of cell killing (GO:0031342)5.56313776
8nuclear pore complex assembly (GO:0051292)5.26759895
9nuclear pore organization (GO:0006999)5.03898344
10photoreceptor cell development (GO:0042461)4.94756418
11eye photoreceptor cell development (GO:0042462)4.93030220
12positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.68356677
13regulation of gamma-delta T cell activation (GO:0046643)4.53872376
14negative thymic T cell selection (GO:0045060)4.51092132
15negative T cell selection (GO:0043383)4.49263643
16photoreceptor cell maintenance (GO:0045494)4.45260399
17regulation of gamma-delta T cell differentiation (GO:0045586)4.43370075
18cellular response to ethanol (GO:0071361)4.33621382
19regulation of posttranscriptional gene silencing (GO:0060147)4.31924157
20regulation of gene silencing by miRNA (GO:0060964)4.31924157
21regulation of gene silencing by RNA (GO:0060966)4.31924157
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.21652558
23pore complex assembly (GO:0046931)4.18439316
24B cell receptor signaling pathway (GO:0050853)4.17595158
25GMP metabolic process (GO:0046037)3.90612553
26positive T cell selection (GO:0043368)3.85622848
27response to interleukin-15 (GO:0070672)3.82926118
28negative regulation of histone methylation (GO:0031061)3.81595737
29antigen processing and presentation of endogenous antigen (GO:0019883)3.76955271
30phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.75105441
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.72371358
32retinal rod cell development (GO:0046548)3.71753421
33positive regulation of granulocyte differentiation (GO:0030854)3.70728517
34positive thymic T cell selection (GO:0045059)3.67343508
35detection of light stimulus involved in visual perception (GO:0050908)3.60757050
36detection of light stimulus involved in sensory perception (GO:0050962)3.60757050
37regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.59520464
38mitotic sister chromatid cohesion (GO:0007064)3.57135795
39cellular response to interleukin-15 (GO:0071350)3.53457878
40negative regulation of T cell mediated immunity (GO:0002710)3.52825971
41T cell selection (GO:0045058)3.51014500
42T cell migration (GO:0072678)3.50617705
43regulation of centriole replication (GO:0046599)3.47872811
44regulation of gene silencing (GO:0060968)3.43291099
45regulation of helicase activity (GO:0051095)3.42232248
46regulation of histone H3-K9 methylation (GO:0051570)3.41486037
47regulation of telomere maintenance via telomerase (GO:0032210)3.40496436
48negative regulation of lymphocyte mediated immunity (GO:0002707)3.39531045
49histone H2A monoubiquitination (GO:0035518)3.38276360
50detection of other organism (GO:0098543)3.34214190
51antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.34159070
52regulation of DNA endoreduplication (GO:0032875)3.32638782
53regulation of B cell differentiation (GO:0045577)3.31273912
54regulation of alpha-beta T cell proliferation (GO:0046640)3.29433108
55positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.29114467
56histone H3-K4 trimethylation (GO:0080182)3.28616533
57positive regulation of B cell differentiation (GO:0045579)3.26334822
58cellular response to light stimulus (GO:0071482)3.24014688
59macrophage activation involved in immune response (GO:0002281)3.23791833
60T-helper cell differentiation (GO:0042093)3.23336309
61CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.23336309
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.23238397
63cellular extravasation (GO:0045123)3.22942784
64detection of bacterium (GO:0016045)3.21442519
65thymic T cell selection (GO:0045061)3.20277458
66response to muramyl dipeptide (GO:0032495)3.19261587
67histone H3-K36 demethylation (GO:0070544)3.16588371
68regulation of histone H3-K27 methylation (GO:0061085)3.16285558
69mRNA transcription from RNA polymerase II promoter (GO:0042789)3.16095320
70histone H3-K4 methylation (GO:0051568)3.15354778
71somatic hypermutation of immunoglobulin genes (GO:0016446)3.15108138
72somatic diversification of immune receptors via somatic mutation (GO:0002566)3.15108138
73histone H4-K12 acetylation (GO:0043983)3.14591475
74negative regulation of B cell proliferation (GO:0030889)3.14443634
75pre-miRNA processing (GO:0031054)3.12936866
76regulation of chromatin silencing (GO:0031935)3.12382055
77interferon-gamma production (GO:0032609)3.12309442
78phototransduction, visible light (GO:0007603)3.12008594
79tolerance induction (GO:0002507)3.11386461
80positive regulation by symbiont of host defense response (GO:0052509)3.09972763
81modulation by symbiont of host defense response (GO:0052031)3.09972763
82modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.09972763
83modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.09972763
84positive regulation by organism of defense response of other organism involved in symbiotic interact3.09972763
85modulation by symbiont of host immune response (GO:0052553)3.09972763
86neutrophil activation involved in immune response (GO:0002283)3.08229414
87leukocyte aggregation (GO:0070486)3.03717076
88phototransduction (GO:0007602)3.02685272
89negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.02127017
90negative regulation of gene silencing (GO:0060969)3.01587450
91antigen receptor-mediated signaling pathway (GO:0050851)3.01381237
92positive regulation of alpha-beta T cell proliferation (GO:0046641)3.01103951
93protein-chromophore linkage (GO:0018298)3.00747342
94mitotic nuclear envelope disassembly (GO:0007077)3.00557546
95positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.00119434
96detection of visible light (GO:0009584)2.98672237
97B cell homeostasis (GO:0001782)2.97840764
98mast cell activation (GO:0045576)2.94833261
99protein localization to kinetochore (GO:0034501)2.94059989
100histone H4-K8 acetylation (GO:0043982)2.93852376
101histone H4-K5 acetylation (GO:0043981)2.93852376
102negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.93846368
103negative regulation of T-helper cell differentiation (GO:0045623)2.93846368
104determination of adult lifespan (GO:0008340)2.93646077
105negative regulation of leukocyte mediated immunity (GO:0002704)2.93143276
106regulation of protein polyubiquitination (GO:1902914)2.92653601
107detection of external biotic stimulus (GO:0098581)2.92577376
108interferon-gamma-mediated signaling pathway (GO:0060333)2.91148867
109regulation of interleukin-8 biosynthetic process (GO:0045414)2.89011019
110alpha-beta T cell differentiation involved in immune response (GO:0002293)2.88533372
111alpha-beta T cell activation involved in immune response (GO:0002287)2.88533372
112T cell differentiation involved in immune response (GO:0002292)2.88533372
113monoubiquitinated protein deubiquitination (GO:0035520)2.87445566
114regulation of sister chromatid cohesion (GO:0007063)2.87241410
115alpha-beta T cell differentiation (GO:0046632)2.86068108
116detection of light stimulus (GO:0009583)2.85953843
117immunoglobulin mediated immune response (GO:0016064)2.84589575
118regulation of tolerance induction (GO:0002643)2.84460819
119regulation of histone methylation (GO:0031060)2.84287940
120visual perception (GO:0007601)2.82343256
121detection of molecule of bacterial origin (GO:0032490)2.82145998
122sensory perception of light stimulus (GO:0050953)2.81725418
123alpha-beta T cell activation (GO:0046631)2.81718333
124membrane disassembly (GO:0030397)2.81228880
125nuclear envelope disassembly (GO:0051081)2.81228880
126hepatocyte apoptotic process (GO:0097284)2.80881776
127myeloid cell activation involved in immune response (GO:0002275)2.79385892
128regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.78888364
129regulation of RNA export from nucleus (GO:0046831)2.78448349
130nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.78018453
131positive regulation of guanylate cyclase activity (GO:0031284)2.77900905
132regulation of T cell tolerance induction (GO:0002664)2.76837987
133negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.76760088
134negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.76432963
135negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.75893519
136regulation of nuclear cell cycle DNA replication (GO:0033262)2.74872086
137positive regulation of mitotic sister chromatid separation (GO:1901970)2.74336762
138positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.74336762
139positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.74336762
140T cell receptor signaling pathway (GO:0050852)2.73788569
141regulation of T cell receptor signaling pathway (GO:0050856)2.73465360
142definitive hemopoiesis (GO:0060216)2.72924600
143B cell proliferation (GO:0042100)2.72915662
144DNA geometric change (GO:0032392)2.72608581
145negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.72546228
146negative regulation of translation, ncRNA-mediated (GO:0040033)2.72546228
147regulation of translation, ncRNA-mediated (GO:0045974)2.72546228
148antigen processing and presentation via MHC class Ib (GO:0002475)2.71387322
149negative regulation of interleukin-12 production (GO:0032695)2.71263557
150DNA duplex unwinding (GO:0032508)2.70750851
151replicative senescence (GO:0090399)2.70441029
152* histone H3-K9 demethylation (GO:0033169)2.69779783
153response to peptidoglycan (GO:0032494)2.69599913
154positive regulation of tolerance induction (GO:0002645)2.69579696
155CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.69420080
156mature B cell differentiation (GO:0002335)2.69374243
157activated T cell proliferation (GO:0050798)2.69347418
158antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.68360907
159DNA replication-dependent nucleosome assembly (GO:0006335)2.65827479
160DNA replication-dependent nucleosome organization (GO:0034723)2.65827479
161positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.63638476
162regulation of B cell proliferation (GO:0030888)2.63252677
163* histone demethylation (GO:0016577)2.62274717
164regulation of interferon-beta biosynthetic process (GO:0045357)2.62017398
165phospholipid efflux (GO:0033700)2.61980508
166regulation of germinal center formation (GO:0002634)2.61641148
167* histone lysine demethylation (GO:0070076)2.61619181
168negative regulation of DNA-dependent DNA replication (GO:2000104)2.61478303
169positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.61400271
170positive regulation of histone H3-K4 methylation (GO:0051571)2.60210173
171mRNA transcription (GO:0009299)2.60157346
172cytoplasmic mRNA processing body assembly (GO:0033962)2.58080911
173stress granule assembly (GO:0034063)2.57010944
174positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.56098818
175negative regulation of adaptive immune response (GO:0002820)2.55132304
176histone H4-K16 acetylation (GO:0043984)2.54988472
177microglial cell activation (GO:0001774)2.54480702
178regulation of mast cell degranulation (GO:0043304)2.54382855
179regulation of granulocyte differentiation (GO:0030852)2.54360413
180chromatin assembly (GO:0031497)2.54056520
181regulation of centrosome duplication (GO:0010824)2.54006492
182regulation of hypersensitivity (GO:0002883)2.53809323
183metaphase plate congression (GO:0051310)2.52468652
184mismatch repair (GO:0006298)2.52173966
185microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.51888325
186positive regulation of DNA-templated transcription, initiation (GO:2000144)2.51400173
187cellular response to radiation (GO:0071478)2.51334586
188tRNA methylation (GO:0030488)2.50233800
189regulation of spindle organization (GO:0090224)2.49928078
190regulation of centrosome cycle (GO:0046605)2.49808089
191mitotic metaphase plate congression (GO:0007080)2.49127337
192response to UV-C (GO:0010225)2.47473480
193regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.47248875
194embryonic placenta development (GO:0001892)2.47048339
195regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.46038299
196protein localization to chromosome, centromeric region (GO:0071459)2.45457319
197positive regulation of histone methylation (GO:0031062)2.44782086

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.64375258
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.71703090
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.60066612
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.70952604
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.51644726
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.24175184
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.22310077
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.09567117
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01240760
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.87108535
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.80451540
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.80451540
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.80451540
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.76834196
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66819213
16MYB_26560356_Chip-Seq_TH2_Human2.63350821
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.57174599
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.57004354
19SCL_19346495_ChIP-Seq_HPC-7_Human2.42914846
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.24338862
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.23008580
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.22003119
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21074940
24GATA1_22025678_ChIP-Seq_K562_Human2.20222402
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.19732614
26ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.13798509
27MYB_26560356_Chip-Seq_TH1_Human2.13452494
28RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09302384
29SMAD_19615063_ChIP-ChIP_OVARY_Human2.07551026
30GATA3_27048872_Chip-Seq_THYMUS_Human1.99123731
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.96384529
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.94239066
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90403204
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87515901
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.87140343
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86097042
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.77413863
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75630408
39VDR_24787735_ChIP-Seq_THP-1_Human1.75057973
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.72968705
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.68243675
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62887407
43* SPI1_23127762_ChIP-Seq_K562_Human1.61348832
44GATA3_26560356_Chip-Seq_TH2_Human1.60908924
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59311550
46MAF_26560356_Chip-Seq_TH1_Human1.59142313
47SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.57437959
48* SPI1_23547873_ChIP-Seq_NB4_Human1.57160200
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.56910664
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.56846805
51TCF3_18692474_ChIP-Seq_MESCs_Mouse1.56644918
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54305843
53ELK1_19687146_ChIP-ChIP_HELA_Human1.53928676
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52979381
55DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.51047089
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.48941141
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48041759
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47587440
59CIITA_25753668_ChIP-Seq_RAJI_Human1.47508347
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.43456866
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42517667
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42359347
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.41786238
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39823258
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38240873
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.35075986
67NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.34600781
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.33666453
69* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33387498
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32146844
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31972161
72MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30203529
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29920081
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29790466
75STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29763023
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28804463
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28155870
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.27717677
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27218290
80GATA1_19941826_ChIP-Seq_K562_Human1.26750247
81UTX_26944678_Chip-Seq_JUKART_Human1.26429540
82GATA2_19941826_ChIP-Seq_K562_Human1.25866691
83RUNX_20019798_ChIP-Seq_JUKART_Human1.25817949
84IRF1_19129219_ChIP-ChIP_H3396_Human1.25402866
85PU_27001747_Chip-Seq_BMDM_Mouse1.24106339
86VDR_24763502_ChIP-Seq_THP-1_Human1.22766321
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22196197
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.20963248
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20323644
90* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20293609
91* TFEB_21752829_ChIP-Seq_HELA_Human1.19727353
92FUS_26573619_Chip-Seq_HEK293_Human1.18898768
93GATA2_21666600_ChIP-Seq_HMVEC_Human1.17929387
94PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17051588
95NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16123639
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16022180
97TP53_16413492_ChIP-PET_HCT116_Human1.15613250
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14243886
99* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13849643
100* FOXO3_23340844_ChIP-Seq_DLD1_Human1.13788491
101STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12353221
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11298480
103POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11294687
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.10338633
105NANOG_21062744_ChIP-ChIP_HESCs_Human1.10026243
106PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09662041
107PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09115955
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08969574
109POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08844311
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08262983
111HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07243580
112RUNX1_22412390_ChIP-Seq_EML_Mouse1.06834208
113TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06568879
114VDR_23849224_ChIP-Seq_CD4+_Human1.06088465
115* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05696785
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05437060
117AR_21572438_ChIP-Seq_LNCaP_Human1.04484413
118FOXA2_19822575_ChIP-Seq_HepG2_Human1.03622013
119* TCF7_22412390_ChIP-Seq_EML_Mouse1.03109151
120CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03099944
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01514869
122* FOXP3_21729870_ChIP-Seq_TREG_Human1.00590864
123CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00489195
124MYC_22102868_ChIP-Seq_BL_Human1.00343438
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00326946
126PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00220060
127HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00104692
128TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99645726
129TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99064531
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98869834
131SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98200546
132SMRT_27268052_Chip-Seq_Bcells_Human0.97249334
133FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95892762
134KDM5A_27292631_Chip-Seq_BREAST_Human0.95476683
135* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95399159
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95184794
137FLI1_27457419_Chip-Seq_LIVER_Mouse0.94619720
138IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94101260
139TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93044940
140GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92738275
141POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92683790
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92058001
143ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91584916
144MAF_26560356_Chip-Seq_TH2_Human0.89927810
145RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89880042
146EWS_26573619_Chip-Seq_HEK293_Human0.89771264
147SALL4_22934838_ChIP-ChIP_CD34+_Human0.89518540
148* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88498753
149GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87585301
150NFE2_27457419_Chip-Seq_LIVER_Mouse0.87197326
151* PRDM14_20953172_ChIP-Seq_ESCs_Human0.86915442
152TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86444476
153IGF1R_20145208_ChIP-Seq_DFB_Human0.84542441
154RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84061867
155EZH2_27294783_Chip-Seq_NPCs_Mouse0.83882904
156TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83786225
157BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82828529
158GATA3_26560356_Chip-Seq_TH1_Human0.82817225
159STAT3_23295773_ChIP-Seq_U87_Human0.81974264
160NANOG_18692474_ChIP-Seq_MESCs_Mouse0.81694660
161SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79744670
162ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79578199
163FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79545282
164CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78754776
165VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78288796
166FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.77990080
167SOX2_16153702_ChIP-ChIP_HESCs_Human0.77265654
168NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.76707159
169OCT4_21477851_ChIP-Seq_ESCs_Mouse0.76344133
170SOX2_18692474_ChIP-Seq_MESCs_Mouse0.76194209
171MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.75904899
172FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75368241
173TCF4_18268006_ChIP-ChIP_LS174T_Human0.74043806
174AHR_22903824_ChIP-Seq_MCF-7_Human0.74000039
175* TP63_23658742_ChIP-Seq_EP156T_Human0.73733861
176LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73622139

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane4.64515744
2MP0006072_abnormal_retinal_apoptosis4.42521496
3MP0005551_abnormal_eye_electrophysiolog4.25253105
4MP0000569_abnormal_digit_pigmentation3.93939744
5MP0005253_abnormal_eye_physiology3.88098973
6MP0003011_delayed_dark_adaptation3.12347933
7MP0003724_increased_susceptibility_to3.09511937
8MP0008057_abnormal_DNA_replication3.01989887
9MP0001800_abnormal_humoral_immune2.97119652
10MP0000685_abnormal_immune_system2.85902848
11MP0003436_decreased_susceptibility_to2.79448800
12MP0003656_abnormal_erythrocyte_physiolo2.72460689
13MP0008058_abnormal_DNA_repair2.70216143
14MP0005000_abnormal_immune_tolerance2.67185493
15MP0010094_abnormal_chromosome_stability2.65572020
16MP0003111_abnormal_nucleus_morphology2.60053232
17MP0005387_immune_system_phenotype2.58585369
18MP0001790_abnormal_immune_system2.58585369
19MP0008007_abnormal_cellular_replicative2.55344098
20MP0002009_preneoplasia2.49259467
21MP0003303_peritoneal_inflammation2.45206233
22MP0002877_abnormal_melanocyte_morpholog2.40165138
23MP0002723_abnormal_immune_serum2.39297147
24MP0006292_abnormal_olfactory_placode2.35773297
25MP0002452_abnormal_antigen_presenting2.31938080
26MP0003077_abnormal_cell_cycle2.30642275
27MP0002420_abnormal_adaptive_immunity2.26921588
28MP0001819_abnormal_immune_cell2.24174690
29MP0002419_abnormal_innate_immunity2.22315406
30MP0005391_vision/eye_phenotype2.21146108
31MP0003787_abnormal_imprinting2.21065961
32MP0009785_altered_susceptibility_to2.14806504
33MP0005025_abnormal_response_to2.13618250
34MP0010352_gastrointestinal_tract_polyps2.02446385
35MP0005076_abnormal_cell_differentiation2.02444457
36MP0004957_abnormal_blastocyst_morpholog2.01422261
37MP0003693_abnormal_embryo_hatching1.99296859
38MP0001324_abnormal_eye_pigmentation1.91651319
39MP0002405_respiratory_system_inflammati1.86159213
40MP0000716_abnormal_immune_system1.84671215
41MP0003191_abnormal_cellular_cholesterol1.84538798
42MP0005464_abnormal_platelet_physiology1.84231878
43MP0004264_abnormal_extraembryonic_tissu1.83456091
44MP0010155_abnormal_intestine_physiology1.83151194
45MP0003172_abnormal_lysosome_physiology1.81975406
46MP0006082_CNS_inflammation1.80059864
47MP0005195_abnormal_posterior_eye1.79658607
48MP0000516_abnormal_urinary_system1.78550808
49MP0005367_renal/urinary_system_phenotyp1.78550808
50MP0000689_abnormal_spleen_morphology1.75249249
51MP0010307_abnormal_tumor_latency1.74950883
52MP0002148_abnormal_hypersensitivity_rea1.74373763
53MP0000465_gastrointestinal_hemorrhage1.74327186
54MP0004947_skin_inflammation1.68550759
55MP0002722_abnormal_immune_system1.66896181
56MP0002653_abnormal_ependyma_morphology1.66883481
57MP0000350_abnormal_cell_proliferation1.60704153
58MP0003890_abnormal_embryonic-extraembry1.54203257
59MP0003183_abnormal_peptide_metabolism1.53587943
60MP0004381_abnormal_hair_follicle1.53562899
61MP0008260_abnormal_autophagy1.51749036
62MP0005075_abnormal_melanosome_morpholog1.50068101
63MP0001845_abnormal_inflammatory_respons1.47662315
64MP0002429_abnormal_blood_cell1.44997087
65MP0003121_genomic_imprinting1.43032474
66MP0003866_abnormal_defecation1.41529029
67MP0009333_abnormal_splenocyte_physiolog1.31206624
68MP0001730_embryonic_growth_arrest1.28820383
69MP0000371_diluted_coat_color1.26853234
70MP0003828_pulmonary_edema1.26726577
71MP0000604_amyloidosis1.26712517
72MP0002396_abnormal_hematopoietic_system1.23351064
73MP0005397_hematopoietic_system_phenotyp1.22753107
74MP0001545_abnormal_hematopoietic_system1.22753107
75MP0002086_abnormal_extraembryonic_tissu1.21350660
76MP0001873_stomach_inflammation1.20877595
77MP0008877_abnormal_DNA_methylation1.19192921
78MP0002084_abnormal_developmental_patter1.17904954
79MP0004885_abnormal_endolymph1.17269843
80MP0001851_eye_inflammation1.16820049
81MP0001853_heart_inflammation1.15604245
82MP0004197_abnormal_fetal_growth/weight/1.13604526
83MP0001697_abnormal_embryo_size1.13431683
84MP0001533_abnormal_skeleton_physiology1.13349086
85MP0002138_abnormal_hepatobiliary_system1.12463243
86MP0003690_abnormal_glial_cell1.11711276
87MP0001672_abnormal_embryogenesis/_devel1.11517596
88MP0005380_embryogenesis_phenotype1.11517596
89MP0003123_paternal_imprinting1.11175302
90MP0001293_anophthalmia1.10555344
91MP0002166_altered_tumor_susceptibility1.08527850
92MP0005671_abnormal_response_to1.07631214
93MP0001286_abnormal_eye_development1.07368253
94MP0003136_yellow_coat_color1.07236217
95MP0003943_abnormal_hepatobiliary_system1.06999152
96MP0002638_abnormal_pupillary_reflex1.05547282
97MP0002085_abnormal_embryonic_tissue1.03788666
98MP0008469_abnormal_protein_level1.03572452
99MP0009703_decreased_birth_body0.99897120
100MP0002006_tumorigenesis0.99611358
101MP0002088_abnormal_embryonic_growth/wei0.99108476
102MP0003984_embryonic_growth_retardation0.98228413
103MP0002090_abnormal_vision0.97038841
104MP0002998_abnormal_bone_remodeling0.95520174
105MP0009764_decreased_sensitivity_to0.93672424
106MP0009840_abnormal_foam_cell0.93110027
107MP0003252_abnormal_bile_duct0.92868998
108MP0002080_prenatal_lethality0.92466524
109MP0000015_abnormal_ear_pigmentation0.92131287
110MP0005365_abnormal_bile_salt0.91016683
111MP0003091_abnormal_cell_migration0.90338102
112MP0002075_abnormal_coat/hair_pigmentati0.89610678
113MP0001661_extended_life_span0.87055438
114MP0001915_intracranial_hemorrhage0.86706545
115MP0003045_fibrosis0.86365478
116MP0002229_neurodegeneration0.85571494
117MP0003941_abnormal_skin_development0.85526691
118MP0002933_joint_inflammation0.85024223
119MP0003786_premature_aging0.84569805
120MP0004883_abnormal_blood_vessel0.82529942
121MP0003763_abnormal_thymus_physiology0.82332889
122MP0000703_abnormal_thymus_morphology0.81834884
123MP0002095_abnormal_skin_pigmentation0.80438605
124MP0004808_abnormal_hematopoietic_stem0.79767857
125MP0006054_spinal_hemorrhage0.78781904
126MP0004484_altered_response_of0.78211054
127MP0001186_pigmentation_phenotype0.76728059
128MP0010234_abnormal_vibrissa_follicle0.76167326
129MP0002925_abnormal_cardiovascular_devel0.75321375
130MP0000313_abnormal_cell_death0.73256795
131MP0009763_increased_sensitivity_to0.73207297
132MP0002398_abnormal_bone_marrow0.73173686
133MP0009278_abnormal_bone_marrow0.73104748
134MP0010329_abnormal_lipoprotein_level0.73100193
135MP0005174_abnormal_tail_pigmentation0.72914643
136MP0009765_abnormal_xenobiotic_induced0.72683154
137MP0005621_abnormal_cell_physiology0.71883626
138MP0000858_altered_metastatic_potential0.71671134
139MP0000249_abnormal_blood_vessel0.71395763
140MP0002019_abnormal_tumor_incidence0.71291974
141MP0001502_abnormal_circadian_rhythm0.70456483
142MP0000609_abnormal_liver_physiology0.70201505
143MP0004147_increased_porphyrin_level0.69955691
144MP0003566_abnormal_cell_adhesion0.69481867
145MP0002132_abnormal_respiratory_system0.66212064
146MP0008961_abnormal_basal_metabolism0.65991044
147MP0003935_abnormal_craniofacial_develop0.65981231
148MP0003221_abnormal_cardiomyocyte_apopto0.65440012
149MP0002092_abnormal_eye_morphology0.64090192
150MP0005384_cellular_phenotype0.64000727
151MP0002136_abnormal_kidney_physiology0.63888547
152MP0003448_altered_tumor_morphology0.63704466
153MP0005310_abnormal_salivary_gland0.63697322
154MP0002752_abnormal_somatic_nervous0.63021488
155MP0005164_abnormal_response_to0.62916691
156MP0009780_abnormal_chondrocyte_physiolo0.62805016
157MP0005083_abnormal_biliary_tract0.62734972
158MP0002127_abnormal_cardiovascular_syste0.61963242
159MP0001666_abnormal_nutrient_absorption0.61433514
160MP0001764_abnormal_homeostasis0.61091129
161MP0000490_abnormal_crypts_of0.59744616
162MP0005257_abnormal_intraocular_pressure0.59129085
163MP0005171_absent_coat_pigmentation0.57612310
164MP0008932_abnormal_embryonic_tissue0.57256269
165MP0001986_abnormal_taste_sensitivity0.56565173
166MP0008004_abnormal_stomach_pH0.56430819
167MP0003300_gastrointestinal_ulcer0.55396718
168MP0005220_abnormal_exocrine_pancreas0.55307223
169MP0001835_abnormal_antigen_presentation0.54877108
170MP0003567_abnormal_fetal_cardiomyocyte0.54724112
171MP0000432_abnormal_head_morphology0.52952515
172MP0009115_abnormal_fat_cell0.52831312

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.96780096
2Bony spicule pigmentary retinopathy (HP:0007737)6.34835445
3Abnormal rod and cone electroretinograms (HP:0008323)4.86882384
4Dyschromatopsia (HP:0007641)4.80763174
5T lymphocytopenia (HP:0005403)4.69016747
6Absent rod-and cone-mediated responses on ERG (HP:0007688)4.64660551
7Recurrent bacterial skin infections (HP:0005406)4.53292736
8Abnormality of T cell number (HP:0011839)4.49162975
9Eczematoid dermatitis (HP:0000976)4.37606378
10Central scotoma (HP:0000603)4.23223690
11Recurrent abscess formation (HP:0002722)4.18255925
12Scotoma (HP:0000575)4.17471896
13Chorioretinal atrophy (HP:0000533)4.13427199
14Pendular nystagmus (HP:0012043)3.98776631
15Pigmentary retinal degeneration (HP:0001146)3.96034420
16Attenuation of retinal blood vessels (HP:0007843)3.91829394
17Cone-rod dystrophy (HP:0000548)3.91122559
18Abnormality of macular pigmentation (HP:0008002)3.89641667
19Stomatitis (HP:0010280)3.89529935
20Decreased central vision (HP:0007663)3.85600459
21Chronic mucocutaneous candidiasis (HP:0002728)3.85398249
22Recurrent cutaneous fungal infections (HP:0011370)3.85398249
23Autoimmune hemolytic anemia (HP:0001890)3.82663853
24Recurrent fungal infections (HP:0002841)3.75761891
25Neoplasm of the oral cavity (HP:0100649)3.71916185
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.61830528
27Type II diabetes mellitus (HP:0005978)3.55440166
28Photophobia (HP:0000613)3.45155187
29Recurrent skin infections (HP:0001581)3.44894126
30Ependymoma (HP:0002888)3.42830717
31Myositis (HP:0100614)3.42753271
32Retrobulbar optic neuritis (HP:0100654)3.41591444
33Optic neuritis (HP:0100653)3.41591444
34Colitis (HP:0002583)3.38964929
35Gingival bleeding (HP:0000225)3.36661169
36Abnormality of T cells (HP:0002843)3.36094510
37Meningitis (HP:0001287)3.31834958
38Gastrointestinal infarctions (HP:0005244)3.30131716
39IgM deficiency (HP:0002850)3.27511692
40Recurrent viral infections (HP:0004429)3.25256299
41Panhypogammaglobulinemia (HP:0003139)3.21508526
42Volvulus (HP:0002580)3.20442507
43Recurrent bronchitis (HP:0002837)3.17392834
44Mediastinal lymphadenopathy (HP:0100721)3.17237478
45Macular degeneration (HP:0000608)3.15379185
46Vasculitis (HP:0002633)3.15320093
47Inflammation of the large intestine (HP:0002037)3.13400106
48Abolished electroretinogram (ERG) (HP:0000550)3.08673883
49Orchitis (HP:0100796)3.05530404
50Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.05243402
51Abnormality of macrophages (HP:0004311)2.99241351
52Posterior subcapsular cataract (HP:0007787)2.98824492
53Agammaglobulinemia (HP:0004432)2.98490414
54Recurrent gram-negative bacterial infections (HP:0005420)2.93792503
55Chronic diarrhea (HP:0002028)2.92871279
56IgG deficiency (HP:0004315)2.92263397
57Spontaneous hematomas (HP:0007420)2.91302815
58Gastrointestinal inflammation (HP:0004386)2.90204505
59IgA deficiency (HP:0002720)2.83339693
60Pustule (HP:0200039)2.81535277
61Abnormality of the astrocytes (HP:0100707)2.81396314
62Astrocytoma (HP:0009592)2.81396314
63Agnosia (HP:0010524)2.80137178
64Elevated erythrocyte sedimentation rate (HP:0003565)2.75980313
65Gingivitis (HP:0000230)2.73634342
66Keratoconjunctivitis sicca (HP:0001097)2.70609737
67Hypoplasia of the thymus (HP:0000778)2.70435203
68Severe combined immunodeficiency (HP:0004430)2.70032529
69Lymphopenia (HP:0001888)2.66507764
70Encephalitis (HP:0002383)2.65810462
71Stomach cancer (HP:0012126)2.65663385
72Vitreoretinal degeneration (HP:0000655)2.60496216
73Medulloblastoma (HP:0002885)2.59559455
74Thyroiditis (HP:0100646)2.58165679
75Abnormality of T cell physiology (HP:0011840)2.57678918
76Epistaxis (HP:0000421)2.55230597
77Keratoconjunctivitis (HP:0001096)2.54228905
78Leukocytosis (HP:0001974)2.52796066
79Osteomyelitis (HP:0002754)2.52639974
80Glioma (HP:0009733)2.52309689
81Pulmonary infiltrates (HP:0002113)2.51989287
82Abnormality of the labia minora (HP:0012880)2.51986423
83Hemoptysis (HP:0002105)2.51758005
84Constricted visual fields (HP:0001133)2.50181729
85Abnormality of cells of the lymphoid lineage (HP:0012140)2.48533211
86Abnormality of eosinophils (HP:0001879)2.46765971
87Abnormality of B cell number (HP:0010975)2.40187034
88Eosinophilia (HP:0001880)2.35634257
89Granulocytopenia (HP:0001913)2.33639799
90Arterial thrombosis (HP:0004420)2.33218415
91Cellulitis (HP:0100658)2.31742236
92Viral hepatitis (HP:0006562)2.31605460
93Autoimmune thrombocytopenia (HP:0001973)2.30061956
94Neoplasm of the tracheobronchial system (HP:0100552)2.28571644
95Retinitis pigmentosa (HP:0000510)2.28213446
96Chest pain (HP:0100749)2.27305833
97Slow saccadic eye movements (HP:0000514)2.27008988
98Pulmonary embolism (HP:0002204)2.25472788
99Recurrent sinusitis (HP:0011108)2.23508704
100Prolonged bleeding time (HP:0003010)2.23172090
101Joint swelling (HP:0001386)2.22978926
102Acute myeloid leukemia (HP:0004808)2.22382142
103Amaurosis fugax (HP:0100576)2.22274287
104Hematochezia (HP:0002573)2.21682280
105Poikilocytosis (HP:0004447)2.20983531
106Gastrointestinal stroma tumor (HP:0100723)2.19437817
107Increased IgE level (HP:0003212)2.19054458
108Abnormality of the prostate (HP:0008775)2.16531337
109Acute hepatic failure (HP:0006554)2.15189126
110Choroideremia (HP:0001139)2.14317397
111Chromosomal breakage induced by crosslinking agents (HP:0003221)2.13372620
112Urticaria (HP:0001025)2.11877502
113Aplasia/Hypoplasia of the fovea (HP:0008060)2.10859087
114Hypoplasia of the fovea (HP:0007750)2.10859087
115Alveolar cell carcinoma (HP:0006519)2.09177384
116Severe visual impairment (HP:0001141)2.08805613
117Birth length less than 3rd percentile (HP:0003561)2.08791208
118Chromsome breakage (HP:0040012)2.08537649
119Intestinal atresia (HP:0011100)2.06949301
120Verrucae (HP:0200043)2.04567340
121Papilloma (HP:0012740)2.04567340
122Abnormality of the fingertips (HP:0001211)2.03507324
123Keratoconus (HP:0000563)2.02939275
124Increased corneal curvature (HP:0100692)2.02939275
125Acanthocytosis (HP:0001927)2.02932464
126Combined immunodeficiency (HP:0005387)2.02332102
127B lymphocytopenia (HP:0010976)2.00889756
128Prominent nose (HP:0000448)1.99687514
129Subacute progressive viral hepatitis (HP:0006572)1.98812661
130Anal stenosis (HP:0002025)1.97786072
131Ectopic kidney (HP:0000086)1.97205739
132Bronchitis (HP:0012387)1.95040851
133Progressive visual loss (HP:0000529)1.94165234
134Supernumerary spleens (HP:0009799)1.93955808
135Colon cancer (HP:0003003)1.90523925
136Thrombophlebitis (HP:0004418)1.90023685
137Polyneuropathy (HP:0001271)1.89894010
138Deep philtrum (HP:0002002)1.89198030
139Abnormality of the common coagulation pathway (HP:0010990)1.88910839
140Rhabdomyosarcoma (HP:0002859)1.88566930
141Hypochromic microcytic anemia (HP:0004840)1.88393928
142Aplastic anemia (HP:0001915)1.87468865
143Scanning speech (HP:0002168)1.87300866
144Hypochromic anemia (HP:0001931)1.87006416
145Gangrene (HP:0100758)1.86966693
146Obstructive lung disease (HP:0006536)1.86418898
147Chronic obstructive pulmonary disease (HP:0006510)1.86418898
148Hypoplastic labia majora (HP:0000059)1.82042877
149Hepatitis (HP:0012115)1.81929803
150Myelodysplasia (HP:0002863)1.81282781
151Papillary thyroid carcinoma (HP:0002895)1.80424676
152Fair hair (HP:0002286)1.78315088
153Subcapsular cataract (HP:0000523)1.78067505
154Malignant gastrointestinal tract tumors (HP:0006749)1.78054636
155Gastrointestinal carcinoma (HP:0002672)1.78054636
156Keratitis (HP:0000491)1.77595429
157Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75017125
158Urethral obstruction (HP:0000796)1.72995700
159Acute lymphatic leukemia (HP:0006721)1.72268381
160Abnormality of the fovea (HP:0000493)1.70673114
161Esophageal atresia (HP:0002032)1.69584529
162Truncal obesity (HP:0001956)1.68556676
163Aplasia/Hypoplasia of the macula (HP:0008059)1.68040794
164Gastrointestinal atresia (HP:0002589)1.66478395
165Wide nasal bridge (HP:0000431)1.66335619
166Neoplasm of the adrenal cortex (HP:0100641)1.65708166
167Abnormality of the salivary glands (HP:0010286)1.64312892
168Abnormality of DNA repair (HP:0003254)1.62667694
169Biliary tract neoplasm (HP:0100574)1.58650124
170Abnormality of the labia majora (HP:0012881)1.58342432
171Sloping forehead (HP:0000340)1.58069187
172Abnormality of the hepatic vasculature (HP:0006707)1.58056449
173Portal hypertension (HP:0001409)1.56563152
174Spinal muscular atrophy (HP:0007269)1.55307049
175Congenital sensorineural hearing impairment (HP:0008527)1.53645536
176Freckling (HP:0001480)1.53388222
177Abnormality of chromosome stability (HP:0003220)1.52873096
178Abnormal biliary tract morphology (HP:0012440)1.49310281
179Transitional cell carcinoma of the bladder (HP:0006740)1.48856556
180Abnormality of homocysteine metabolism (HP:0010919)1.48245828
181Homocystinuria (HP:0002156)1.48245828
182Neoplasm of striated muscle (HP:0009728)1.48056115
183Premature graying of hair (HP:0002216)1.47443702
184Pancreatic fibrosis (HP:0100732)1.43916142
185Septo-optic dysplasia (HP:0100842)1.43733312
186Genetic anticipation (HP:0003743)1.42317431
187Hypoplasia of the maxilla (HP:0000327)1.42255604
188Lip pit (HP:0100267)1.41940530
189Retinal atrophy (HP:0001105)1.41892105
190Deviation of the thumb (HP:0009603)1.41553803
191Basal cell carcinoma (HP:0002671)1.41088915
192Hypoplastic ischia (HP:0003175)1.40229386
193Lymphoma (HP:0002665)1.38730692
194Dysmetric saccades (HP:0000641)1.38401949
195Bone marrow hypocellularity (HP:0005528)1.37708384
196Trigonocephaly (HP:0000243)1.37697971
197Proximal placement of thumb (HP:0009623)1.37420098

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.00630803
2AKT33.68436966
3GRK13.35973178
4RIPK43.29905159
5BLK3.18626772
6BRD42.59042356
7MKNK22.50362595
8FES2.29462331
9IRAK42.16752038
10CDC72.13308947
11BMPR22.13215489
12BUB12.09989855
13TAOK32.09549028
14ZAK2.09463635
15IKBKE2.03733698
16EPHA22.01522187
17MAP3K131.95645009
18BTK1.95315260
19PRPF4B1.92406268
20PIK3CG1.90097347
21GRK61.89950035
22ACVR1B1.89946446
23FLT31.87906712
24SYK1.86896815
25TSSK61.79478734
26INSRR1.78819065
27TTK1.72973697
28ATR1.66433315
29MKNK11.66132209
30NEK21.65235068
31TXK1.62661133
32CAMKK21.62213416
33PASK1.61903858
34NEK11.58960466
35WEE11.57728387
36PLK31.46890616
37CHEK21.42373475
38HCK1.41543028
39FGR1.39986305
40CHEK11.39666733
41RPS6KA41.39331574
42ZAP701.38863757
43CSF1R1.37217728
44LYN1.35402456
45LCK1.31503565
46ATM1.31490663
47NLK1.26180326
48RPS6KB21.25204746
49LATS11.24902682
50CAMK1D1.22903425
51BRSK21.21825910
52ERBB31.21064319
53SIK31.20882390
54FRK1.16013955
55IKBKB1.15030742
56SGK21.14435540
57JAK21.12088670
58MAPK111.10250037
59FGFR41.09211197
60JAK31.04966626
61SRPK11.00455753
62HIPK21.00095755
63TNK20.99717318
64VRK10.97954896
65PLK10.97110319
66CDK70.97097650
67AURKB0.95783146
68PDK10.94203729
69TBK10.94178736
70MARK30.93864308
71STK240.93293864
72YES10.91515571
73TEC0.91297311
74TGFBR10.89606587
75CSNK1D0.89525225
76EIF2AK30.89254548
77CDK20.88845963
78MARK20.88616024
79TIE10.88198603
80DYRK30.87770780
81MAP2K30.87320171
82PRKCQ0.86912055
83MELK0.86048354
84SGK30.85032263
85CCNB10.84901014
86STK100.84473447
87MAP4K10.83655107
88PDGFRB0.82577952
89CDK60.82488320
90CDK10.79975495
91CDK90.78818535
92FGFR30.78362214
93NEK60.78152081
94CAMKK10.75486621
95MAPK140.75247317
96MAP3K70.74980047
97CHUK0.72108942
98MAP3K20.71867640
99PNCK0.71247808
100CDK30.69839694
101PTK2B0.68270779
102AKT10.67245755
103STK40.67007478
104GSK3B0.66450496
105MTOR0.66437215
106MAP3K10.65936494
107PIM10.64045299
108RPS6KB10.63540061
109STK30.63285257
110ALK0.63226900
111PRKDC0.62907084
112SGK2230.62091334
113SGK4940.62091334
114CSK0.60397548
115STK380.59156524
116TRPM70.58593164
117FGFR10.58570704
118EGFR0.57862535
119JAK10.57622534
120CAMK40.57083787
121RPS6KA50.56320352
122MAP3K140.55519250
123RET0.55285522
124MAPK100.54814741
125MAP3K100.54455072
126MAPK120.52269907
127MAP3K60.51743457
128PRKAA20.51386016
129EPHA30.51252891
130MAPK70.50635130
131PINK10.50548429
132NEK90.50414968
133NUAK10.50252194
134KSR20.49335314
135FYN0.48926573
136CDK40.48253477
137MST40.48213052
138CAMK1G0.48210340
139MAP3K50.48127140
140CSNK1E0.48109831
141MAPK10.47634725
142SCYL20.46824726
143SGK10.46635420
144TLK10.45878681
145MAP2K20.45854082
146PIK3CA0.45193306
147WNK10.45036234
148ABL10.42032561
149PKN20.41327208
150MATK0.41205695
151PDPK10.40858150
152KIT0.39908955
153ITK0.39710074
154TYK20.39483450
155CDC42BPA0.38843235
156SIK20.38172507
157PRKAA10.36840789
158EIF2AK20.36639551
159BMX0.36181761

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047447.06827851
2Autoimmune thyroid disease_Homo sapiens_hsa053202.54111960
3B cell receptor signaling pathway_Homo sapiens_hsa046622.52017192
4Mismatch repair_Homo sapiens_hsa034302.39443748
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32785979
6Staphylococcus aureus infection_Homo sapiens_hsa051502.30905101
7Asthma_Homo sapiens_hsa053102.20518119
8Non-homologous end-joining_Homo sapiens_hsa034501.84854167
9RNA transport_Homo sapiens_hsa030131.82447849
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75939260
11RNA degradation_Homo sapiens_hsa030181.66788321
12DNA replication_Homo sapiens_hsa030301.65419113
13Fanconi anemia pathway_Homo sapiens_hsa034601.64827245
14Tuberculosis_Homo sapiens_hsa051521.63933868
15One carbon pool by folate_Homo sapiens_hsa006701.63577679
16Cell cycle_Homo sapiens_hsa041101.63114710
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59707247
18mRNA surveillance pathway_Homo sapiens_hsa030151.58564122
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57582005
20Spliceosome_Homo sapiens_hsa030401.46552874
21Circadian rhythm_Homo sapiens_hsa047101.45848039
22Nucleotide excision repair_Homo sapiens_hsa034201.40469724
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39613767
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33615790
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32966281
26Basal transcription factors_Homo sapiens_hsa030221.32483609
27Viral myocarditis_Homo sapiens_hsa054161.32226709
28Base excision repair_Homo sapiens_hsa034101.30951572
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30876402
30Acute myeloid leukemia_Homo sapiens_hsa052211.27301169
31Homologous recombination_Homo sapiens_hsa034401.26628618
32TNF signaling pathway_Homo sapiens_hsa046681.24512180
33Antigen processing and presentation_Homo sapiens_hsa046121.22223205
34p53 signaling pathway_Homo sapiens_hsa041151.21296410
35RNA polymerase_Homo sapiens_hsa030201.20237381
36Inositol phosphate metabolism_Homo sapiens_hsa005621.17568312
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16740450
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.14421370
39Platelet activation_Homo sapiens_hsa046111.13045221
40mTOR signaling pathway_Homo sapiens_hsa041501.12182634
41Malaria_Homo sapiens_hsa051441.12099507
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12045780
43Herpes simplex infection_Homo sapiens_hsa051681.01236085
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.00027018
45Other glycan degradation_Homo sapiens_hsa005110.98974746
46Viral carcinogenesis_Homo sapiens_hsa052030.96680135
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96170756
48MicroRNAs in cancer_Homo sapiens_hsa052060.95850456
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93361034
50Primary immunodeficiency_Homo sapiens_hsa053400.92450017
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92395076
52Systemic lupus erythematosus_Homo sapiens_hsa053220.91620993
53Hepatitis C_Homo sapiens_hsa051600.90701940
54African trypanosomiasis_Homo sapiens_hsa051430.89620842
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89236713
56HTLV-I infection_Homo sapiens_hsa051660.87900440
57Adherens junction_Homo sapiens_hsa045200.87176307
58Rheumatoid arthritis_Homo sapiens_hsa053230.87127538
59Measles_Homo sapiens_hsa051620.85953939
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85219460
61Pancreatic cancer_Homo sapiens_hsa052120.85076587
62Notch signaling pathway_Homo sapiens_hsa043300.81454098
63Dorso-ventral axis formation_Homo sapiens_hsa043200.81306826
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78936208
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78449100
66Alcoholism_Homo sapiens_hsa050340.77316706
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76342245
68Lysine degradation_Homo sapiens_hsa003100.74367969
69Small cell lung cancer_Homo sapiens_hsa052220.73481170
70Colorectal cancer_Homo sapiens_hsa052100.73346294
71Epstein-Barr virus infection_Homo sapiens_hsa051690.69926043
72Oocyte meiosis_Homo sapiens_hsa041140.68634249
73Hematopoietic cell lineage_Homo sapiens_hsa046400.68466703
74Prostate cancer_Homo sapiens_hsa052150.67808011
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67278696
76Insulin resistance_Homo sapiens_hsa049310.67264891
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.66045481
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65922089
79T cell receptor signaling pathway_Homo sapiens_hsa046600.64885399
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64480886
81Type II diabetes mellitus_Homo sapiens_hsa049300.63965139
82Hippo signaling pathway_Homo sapiens_hsa043900.63617869
83Purine metabolism_Homo sapiens_hsa002300.63220443
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63179188
85Renal cell carcinoma_Homo sapiens_hsa052110.62262420
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.62188373
87ABC transporters_Homo sapiens_hsa020100.60968920
88Regulation of autophagy_Homo sapiens_hsa041400.59639319
89Long-term potentiation_Homo sapiens_hsa047200.59345753
90Legionellosis_Homo sapiens_hsa051340.58214079
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58007244
92Endometrial cancer_Homo sapiens_hsa052130.57506065
93Insulin secretion_Homo sapiens_hsa049110.56449133
94Leishmaniasis_Homo sapiens_hsa051400.56203698
95Pathways in cancer_Homo sapiens_hsa052000.56146346
96Wnt signaling pathway_Homo sapiens_hsa043100.55693536
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.55654367
98VEGF signaling pathway_Homo sapiens_hsa043700.55554554
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55072748
100Influenza A_Homo sapiens_hsa051640.53925453
101TGF-beta signaling pathway_Homo sapiens_hsa043500.53313646
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.51170998
103Type I diabetes mellitus_Homo sapiens_hsa049400.50788369
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.50435925
105Pertussis_Homo sapiens_hsa051330.50314231
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50168428
107Hepatitis B_Homo sapiens_hsa051610.49934558
108GnRH signaling pathway_Homo sapiens_hsa049120.49810434
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49358671
110Phagosome_Homo sapiens_hsa041450.49060721
111FoxO signaling pathway_Homo sapiens_hsa040680.48718854
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48596108
113Shigellosis_Homo sapiens_hsa051310.48384839
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.47628784
115Complement and coagulation cascades_Homo sapiens_hsa046100.46486800
116ErbB signaling pathway_Homo sapiens_hsa040120.46419759
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.46113160
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45517027
119Proteoglycans in cancer_Homo sapiens_hsa052050.45269912
120MAPK signaling pathway_Homo sapiens_hsa040100.44709786
121Chemokine signaling pathway_Homo sapiens_hsa040620.44157616
122HIF-1 signaling pathway_Homo sapiens_hsa040660.43953361
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.43618494
124Non-small cell lung cancer_Homo sapiens_hsa052230.42899645
125Osteoclast differentiation_Homo sapiens_hsa043800.41969301
126Graft-versus-host disease_Homo sapiens_hsa053320.41963776
127Apoptosis_Homo sapiens_hsa042100.41800479
128Chronic myeloid leukemia_Homo sapiens_hsa052200.41667860
129Vitamin digestion and absorption_Homo sapiens_hsa049770.41657793
130Morphine addiction_Homo sapiens_hsa050320.41001661
131N-Glycan biosynthesis_Homo sapiens_hsa005100.40982582
132Toxoplasmosis_Homo sapiens_hsa051450.40860868
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39551248
134Allograft rejection_Homo sapiens_hsa053300.37938839
135Pyrimidine metabolism_Homo sapiens_hsa002400.37838670
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.36995938
137GABAergic synapse_Homo sapiens_hsa047270.36383876
138Melanoma_Homo sapiens_hsa052180.36147405
139Thyroid cancer_Homo sapiens_hsa052160.36018310
140Choline metabolism in cancer_Homo sapiens_hsa052310.35362371
141Glucagon signaling pathway_Homo sapiens_hsa049220.35128072
142Circadian entrainment_Homo sapiens_hsa047130.34869908
143Prolactin signaling pathway_Homo sapiens_hsa049170.34730270
144cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34248376
145Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33876385
146Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33286775
147Lysosome_Homo sapiens_hsa041420.32601656
148Pancreatic secretion_Homo sapiens_hsa049720.29217070
149Glioma_Homo sapiens_hsa052140.28222896
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27384469
151Fatty acid biosynthesis_Homo sapiens_hsa000610.27360856

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