KDM2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)4.40192554
2negative regulation of erythrocyte differentiation (GO:0045647)4.17891135
3histone H3-K4 trimethylation (GO:0080182)4.00768103
4mitotic sister chromatid cohesion (GO:0007064)3.91666962
5response to muramyl dipeptide (GO:0032495)3.80518207
6pre-miRNA processing (GO:0031054)3.77213611
7positive regulation of histone deacetylation (GO:0031065)3.75846019
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.72596056
9positive regulation by organism of defense response of other organism involved in symbiotic interact3.72596056
10modulation by symbiont of host immune response (GO:0052553)3.72596056
11positive regulation by symbiont of host defense response (GO:0052509)3.72596056
12modulation by symbiont of host defense response (GO:0052031)3.72596056
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.72596056
14nuclear pore complex assembly (GO:0051292)3.67694292
15positive regulation of gamma-delta T cell activation (GO:0046645)3.65677109
16positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.59267621
17detection of other organism (GO:0098543)3.50824602
18detection of bacterium (GO:0016045)3.44766511
19macrophage activation involved in immune response (GO:0002281)3.41857691
20leukocyte aggregation (GO:0070486)3.36335747
21mannose metabolic process (GO:0006013)3.35676847
22histone H3-K4 methylation (GO:0051568)3.33254965
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.32676184
24negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.25587821
25negative regulation of translation, ncRNA-mediated (GO:0040033)3.25587821
26regulation of translation, ncRNA-mediated (GO:0045974)3.25587821
27regulation of gamma-delta T cell differentiation (GO:0045586)3.22600483
28regulation of histone H3-K27 methylation (GO:0061085)3.21687530
29germinal center formation (GO:0002467)3.19111350
30positive thymic T cell selection (GO:0045059)3.19065540
31tolerance induction (GO:0002507)3.14902676
32response to peptidoglycan (GO:0032494)3.14170601
33insulin-like growth factor receptor signaling pathway (GO:0048009)3.07157496
34nuclear pore organization (GO:0006999)3.06798629
35histone H3-K9 demethylation (GO:0033169)3.03258796
36growth hormone receptor signaling pathway (GO:0060396)3.02552488
37peptidyl-lysine trimethylation (GO:0018023)3.01801675
38regulation of gamma-delta T cell activation (GO:0046643)2.97657313
39negative regulation of T cell mediated immunity (GO:0002710)2.97060389
40cellular extravasation (GO:0045123)2.96379854
41embryonic retina morphogenesis in camera-type eye (GO:0060059)2.95775260
42response to laminar fluid shear stress (GO:0034616)2.95610972
43negative regulation of lymphocyte mediated immunity (GO:0002707)2.95019016
44response to interleukin-15 (GO:0070672)2.94217461
45response to type I interferon (GO:0034340)2.93283383
46regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.91997963
47regulation of interferon-beta biosynthetic process (GO:0045357)2.91294145
48detection of external biotic stimulus (GO:0098581)2.90232360
49glucocorticoid receptor signaling pathway (GO:0042921)2.88717936
50cellular response to type I interferon (GO:0071357)2.88483584
51type I interferon signaling pathway (GO:0060337)2.88483584
52regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.85938463
53positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.85938463
54positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.82603600
55embryonic camera-type eye morphogenesis (GO:0048596)2.81891453
56pore complex assembly (GO:0046931)2.80696640
57NLS-bearing protein import into nucleus (GO:0006607)2.80283814
58antigen processing and presentation via MHC class Ib (GO:0002475)2.78008106
59regulation of type I interferon-mediated signaling pathway (GO:0060338)2.77997492
60histone lysine methylation (GO:0034968)2.77616441
61positive T cell selection (GO:0043368)2.77154408
62positive regulation of Cdc42 GTPase activity (GO:0043089)2.76241770
63thymic T cell selection (GO:0045061)2.74892003
64embryonic process involved in female pregnancy (GO:0060136)2.74826907
65negative T cell selection (GO:0043383)2.74236517
66T cell migration (GO:0072678)2.73320261
67negative regulation of leukocyte mediated immunity (GO:0002704)2.72678881
68regulation of interleukin-12 biosynthetic process (GO:0045075)2.71673368
69negative thymic T cell selection (GO:0045060)2.71235458
70negative regulation of histone methylation (GO:0031061)2.71108371
71NIK/NF-kappaB signaling (GO:0038061)2.69695375
72negative regulation of granulocyte differentiation (GO:0030853)2.69625890
73regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.69622983
74positive regulation of mRNA catabolic process (GO:0061014)2.68207298
75cellular response to growth hormone stimulus (GO:0071378)2.67705999
76antigen processing and presentation of endogenous antigen (GO:0019883)2.66985319
77regulation of RNA export from nucleus (GO:0046831)2.64488871
78regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.63964330
79positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.63964330
80definitive hemopoiesis (GO:0060216)2.63384749
81detection of molecule of bacterial origin (GO:0032490)2.62979089
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.61690342
83regulation of necroptotic process (GO:0060544)2.60981282
84positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.60830159
85positive regulation of Rap GTPase activity (GO:0032854)2.60201739
86regulation of ARF protein signal transduction (GO:0032012)2.59997750
87negative regulation of interleukin-12 production (GO:0032695)2.59477308
88neutrophil activation involved in immune response (GO:0002283)2.59344197
89T cell selection (GO:0045058)2.59144883
90antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.58716895
91antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.58716895
92regulation of DNA endoreduplication (GO:0032875)2.58390478
93response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.57940164
94response to host (GO:0075136)2.57940164
95response to host defenses (GO:0052200)2.57940164
96regulation of T cell tolerance induction (GO:0002664)2.57198293
97mRNA stabilization (GO:0048255)2.57049604
98RNA stabilization (GO:0043489)2.57049604
99detection of biotic stimulus (GO:0009595)2.56879728
100positive regulation of granulocyte differentiation (GO:0030854)2.56859535
101B cell homeostasis (GO:0001782)2.56617205
102regulation of mRNA catabolic process (GO:0061013)2.56180814
103germ cell migration (GO:0008354)2.55829828
104regulation of B cell differentiation (GO:0045577)2.55274844
105negative regulation of toll-like receptor signaling pathway (GO:0034122)2.55166028
106corticosteroid receptor signaling pathway (GO:0031958)2.54464751
107regulation of tolerance induction (GO:0002643)2.53785895
108positive regulation of protein deacetylation (GO:0090312)2.53481483
109regulation of dendritic cell antigen processing and presentation (GO:0002604)2.53223053
1103-UTR-mediated mRNA stabilization (GO:0070935)2.53057033
111positive regulation of B cell differentiation (GO:0045579)2.51857102
112* histone H3-K36 demethylation (GO:0070544)2.51252608
113negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.49585143
114positive regulation of gene expression, epigenetic (GO:0045815)2.49294652
115regulation of histone deacetylation (GO:0031063)2.47529595
116negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.47178120
117response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.45999808
118response to host immune response (GO:0052572)2.45999808
119regulation of leukocyte degranulation (GO:0043300)2.43305187
120defense response to protozoan (GO:0042832)2.43127188
121histone H3-K9 methylation (GO:0051567)2.41823594
122histone H3-K9 modification (GO:0061647)2.41224384
123CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.39828880
124regulation of T-helper 2 cell differentiation (GO:0045628)2.39595830
125cellular response to interleukin-15 (GO:0071350)2.39186464
126peptidyl-lysine methylation (GO:0018022)2.38923761
127regulation of alpha-beta T cell proliferation (GO:0046640)2.38440069
128positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.37771892
129positive regulation of tolerance induction (GO:0002645)2.36409872
130signal complex assembly (GO:0007172)2.36270092
131positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.36246573
132cellular response to virus (GO:0098586)2.34447911
133regulation of protein polyubiquitination (GO:1902914)2.34117681
134interferon-gamma-mediated signaling pathway (GO:0060333)2.33279915
135response to protozoan (GO:0001562)2.33271442
136* histone lysine demethylation (GO:0070076)2.31969786
137B cell receptor signaling pathway (GO:0050853)2.31822727
138peptidyl-lysine dimethylation (GO:0018027)2.31517055
139positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.30949599
140macrophage activation (GO:0042116)2.30431874
141epithelial cell differentiation involved in prostate gland development (GO:0060742)2.30298889
142regulation of nucleobase-containing compound transport (GO:0032239)2.28087420
143embryonic eye morphogenesis (GO:0048048)2.27651631
144heart morphogenesis (GO:0003007)2.25321607
145interkinetic nuclear migration (GO:0022027)2.20363712
146* histone demethylation (GO:0016577)2.20100432
147embryonic hemopoiesis (GO:0035162)2.19872495
148JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.19220380
149hepatocyte apoptotic process (GO:0097284)2.18747061
150coronary vasculature morphogenesis (GO:0060977)2.15999841
151histone mRNA catabolic process (GO:0071044)2.13635873
152regulation of histone H3-K9 methylation (GO:0051570)2.13128728
153regulation of protein deacetylation (GO:0090311)2.09849621
154hippo signaling (GO:0035329)2.09551556
155histone H4-K16 acetylation (GO:0043984)2.09314576
156stress granule assembly (GO:0034063)2.09156636
157negative regulation of stress fiber assembly (GO:0051497)2.08297136
158negative regulation of cell killing (GO:0031342)2.08209296
159negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.08209296
160cell-substrate junction assembly (GO:0007044)2.06277761
161regulation of histone methylation (GO:0031060)2.05023511
162histone methylation (GO:0016571)2.03561420
163fibroblast migration (GO:0010761)2.03302738
164megakaryocyte development (GO:0035855)2.01190619
165negative regulation of phagocytosis (GO:0050765)1.99877987
166positive regulation of hormone biosynthetic process (GO:0046886)1.99758561
167regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.98787618
168negative regulation of fatty acid transport (GO:2000192)1.98638258
169positive regulation of mitotic metaphase/anaphase transition (GO:0045842)1.98444382
170positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)1.98444382
171positive regulation of mitotic sister chromatid separation (GO:1901970)1.98444382
172hemidesmosome assembly (GO:0031581)1.98317948
173regulation of mRNA stability (GO:0043488)1.98154997
174regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00431.98144157
175regulation of B cell receptor signaling pathway (GO:0050855)1.97969810
176face morphogenesis (GO:0060325)1.96886622

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.53094824
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.12527866
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.79374965
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.70974547
5E2F7_22180533_ChIP-Seq_HELA_Human2.83822834
6MYC_22102868_ChIP-Seq_BL_Human2.74852957
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.52082139
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.38396195
9TCF7_22412390_ChIP-Seq_EML_Mouse2.34198099
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.33020462
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.28805170
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.16942666
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.15897513
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.14561971
15RUNX_20019798_ChIP-Seq_JUKART_Human2.14214330
16* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.08431079
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.05403174
18SCL_19346495_ChIP-Seq_HPC-7_Human1.99551552
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.93046867
20KDM2B_26808549_Chip-Seq_DND41_Human1.90545020
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89443762
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.84336302
23* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77492502
24LXR_22292898_ChIP-Seq_THP-1_Human1.77369237
25* MAF_26560356_Chip-Seq_TH2_Human1.76585023
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74427440
27DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.73892231
28MAF_26560356_Chip-Seq_TH1_Human1.71715247
29VDR_21846776_ChIP-Seq_THP-1_Human1.70193196
30RACK7_27058665_Chip-Seq_MCF-7_Human1.68740880
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.67090060
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66084138
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64492122
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.64443632
35* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63965257
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.61144369
37MYB_26560356_Chip-Seq_TH1_Human1.60915171
38UTX_26944678_Chip-Seq_JUKART_Human1.59125591
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58671196
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58637789
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58420396
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56205281
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.56141949
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55277434
45MYB_26560356_Chip-Seq_TH2_Human1.55233106
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.54863168
47* IRF8_27001747_Chip-Seq_BMDM_Mouse1.52095729
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50914728
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50547021
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47953069
51FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.47941398
52KDM2B_26808549_Chip-Seq_JURKAT_Human1.47486884
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46693731
54* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45607573
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.44639421
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40376722
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.39962215
58* SPI1_23547873_ChIP-Seq_NB4_Human1.39501682
59RUNX1_27514584_Chip-Seq_MCF-7_Human1.38251405
60PKCTHETA_26484144_Chip-Seq_BREAST_Human1.37928568
61VDR_24763502_ChIP-Seq_THP-1_Human1.36986144
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.35779170
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35714417
64* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35411046
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34793941
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34694504
67TP53_16413492_ChIP-PET_HCT116_Human1.34565766
68* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33625931
69* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32935615
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30085478
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29838600
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.28946560
73SPI1_23127762_ChIP-Seq_K562_Human1.27693491
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26033514
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25462603
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25238736
77GATA1_22025678_ChIP-Seq_K562_Human1.25219501
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24466117
79CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22817378
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22808889
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22017037
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20784388
83BRD4_25478319_ChIP-Seq_HGPS_Human1.20704590
84SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16209707
85SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16209707
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14692377
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14675500
88NCOR1_26117541_ChIP-Seq_K562_Human1.14618067
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14583654
90CLOCK_20551151_ChIP-Seq_293T_Human1.14316777
91ELK3_25401928_ChIP-Seq_HUVEC_Human1.14254431
92AHR_22903824_ChIP-Seq_MCF-7_Human1.13435260
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13302141
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12994406
95CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12721455
96FOXA2_19822575_ChIP-Seq_HepG2_Human1.12452761
97GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12428282
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12180806
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11899486
100* GATA3_27048872_Chip-Seq_THYMUS_Human1.11230128
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11018688
102RUNX1_22412390_ChIP-Seq_EML_Mouse1.10852878
103KDM2B_26808549_Chip-Seq_K562_Human1.10822182
104RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10398845
105RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10339968
106* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09232870
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09143862
108ESR1_21235772_ChIP-Seq_MCF-7_Human1.08581643
109SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08578404
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08557601
111GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07516992
112CIITA_25753668_ChIP-Seq_RAJI_Human1.07058156
113* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07030198
114ISL1_27105846_Chip-Seq_CPCs_Mouse1.06609560
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06160441
116FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05628548
117Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05319066
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04680848
119GATA6_25053715_ChIP-Seq_YYC3_Human1.03648779
120VDR_24787735_ChIP-Seq_THP-1_Human1.03080283
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02894052
122* SMC4_20622854_ChIP-Seq_HELA_Human1.02618582
123NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01943006
124CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01279210
125* PU_27001747_Chip-Seq_BMDM_Mouse1.01214515
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00351177
127ESR1_20079471_ChIP-ChIP_T-47D_Human0.99460194
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98777033
129CREB1_26743006_Chip-Seq_LNCaP_Human0.98483142
130GATA1_19941826_ChIP-Seq_K562_Human0.98039941
131EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97490608
132HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96682119
133PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95458227
134SA1_27219007_Chip-Seq_ERYTHROID_Human0.94079918
135* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92427832

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.47425694
2MP0003300_gastrointestinal_ulcer2.97005188
3MP0010352_gastrointestinal_tract_polyps2.79197170
4MP0005076_abnormal_cell_differentiation2.71881970
5MP0002166_altered_tumor_susceptibility2.55459218
6MP0005451_abnormal_body_composition2.44784052
7MP0003724_increased_susceptibility_to2.37741806
8MP0004808_abnormal_hematopoietic_stem2.31655750
9MP0003705_abnormal_hypodermis_morpholog2.27495584
10MP0005000_abnormal_immune_tolerance2.18770494
11MP0008260_abnormal_autophagy2.06547849
12MP0005025_abnormal_response_to2.04408988
13MP0002419_abnormal_innate_immunity2.03788058
14MP0002009_preneoplasia2.02005519
15MP0003045_fibrosis1.99837853
16MP0009278_abnormal_bone_marrow1.96203941
17MP0002006_tumorigenesis1.89413980
18MP0004381_abnormal_hair_follicle1.84309879
19MP0003191_abnormal_cellular_cholesterol1.84076279
20MP0002877_abnormal_melanocyte_morpholog1.83727486
21MP0002396_abnormal_hematopoietic_system1.82025030
22MP0003566_abnormal_cell_adhesion1.79276808
23MP0003172_abnormal_lysosome_physiology1.77357069
24MP0009333_abnormal_splenocyte_physiolog1.70442436
25MP0008438_abnormal_cutaneous_collagen1.69827364
26MP0000733_abnormal_muscle_development1.65991040
27MP0008961_abnormal_basal_metabolism1.65849822
28MP0001790_abnormal_immune_system1.62942905
29MP0005387_immune_system_phenotype1.62942905
30MP0003787_abnormal_imprinting1.61538546
31MP0010234_abnormal_vibrissa_follicle1.59329529
32MP0001835_abnormal_antigen_presentation1.59318773
33MP0005310_abnormal_salivary_gland1.59037101
34MP0003763_abnormal_thymus_physiology1.55958172
35MP0003303_peritoneal_inflammation1.55134785
36MP0010307_abnormal_tumor_latency1.54973635
37MP0001800_abnormal_humoral_immune1.54101563
38MP0000685_abnormal_immune_system1.52057939
39MP0001533_abnormal_skeleton_physiology1.49219220
40MP0009785_altered_susceptibility_to1.48179614
41MP0005409_darkened_coat_color1.47980580
42MP0001851_eye_inflammation1.44302534
43MP0003091_abnormal_cell_migration1.41465858
44MP0000858_altered_metastatic_potential1.40050203
45MP0002796_impaired_skin_barrier1.37251683
46MP0003866_abnormal_defecation1.35652988
47MP0004185_abnormal_adipocyte_glucose1.34453017
48MP0005248_abnormal_Harderian_gland1.33872006
49MP0004264_abnormal_extraembryonic_tissu1.32243254
50MP0005464_abnormal_platelet_physiology1.31875726
51MP0005503_abnormal_tendon_morphology1.31659400
52MP0000703_abnormal_thymus_morphology1.29020878
53MP0005023_abnormal_wound_healing1.28879301
54MP0005275_abnormal_skin_tensile1.25515311
55MP0001348_abnormal_lacrimal_gland1.25412577
56MP0002398_abnormal_bone_marrow1.25350263
57MP0004197_abnormal_fetal_growth/weight/1.23071861
58MP0002060_abnormal_skin_morphology1.21567261
59MP0009703_decreased_birth_body1.21564758
60MP0005058_abnormal_lysosome_morphology1.21561302
61MP0001845_abnormal_inflammatory_respons1.20974907
62MP0002452_abnormal_antigen_presenting1.20159142
63MP0002148_abnormal_hypersensitivity_rea1.19964639
64MP0001873_stomach_inflammation1.19629740
65MP0000767_abnormal_smooth_muscle1.18497923
66MP0001545_abnormal_hematopoietic_system1.17122487
67MP0005397_hematopoietic_system_phenotyp1.17122487
68MP0005671_abnormal_response_to1.17097346
69MP0003935_abnormal_craniofacial_develop1.16625989
70MP0010155_abnormal_intestine_physiology1.16162761
71MP0006082_CNS_inflammation1.15988753
72MP0003252_abnormal_bile_duct1.12679535
73MP0002925_abnormal_cardiovascular_devel1.12242705
74MP0003828_pulmonary_edema1.11528369
75MP0004947_skin_inflammation1.11195110
76MP0010678_abnormal_skin_adnexa1.10215686
77MP0001853_heart_inflammation1.09162515
78MP0000428_abnormal_craniofacial_morphol1.08376981
79MP0005666_abnormal_adipose_tissue1.08319936
80MP0000383_abnormal_hair_follicle1.08186760
81MP0000465_gastrointestinal_hemorrhage1.06939671
82MP0001849_ear_inflammation1.06426606
83MP0005375_adipose_tissue_phenotype1.05249519
84MP0002420_abnormal_adaptive_immunity1.05201188
85MP0002928_abnormal_bile_duct1.04635215
86MP0010630_abnormal_cardiac_muscle1.02685119
87MP0001819_abnormal_immune_cell1.02647444
88MP0003453_abnormal_keratinocyte_physiol1.02633352
89MP0003115_abnormal_respiratory_system1.01244102
90MP0004510_myositis1.01047390
91MP0001879_abnormal_lymphatic_vessel1.00990870
92MP0006054_spinal_hemorrhage1.00295122
93MP0000716_abnormal_immune_system1.00273540
94MP0002254_reproductive_system_inflammat0.99375595
95MP0002933_joint_inflammation0.99300926
96MP0003567_abnormal_fetal_cardiomyocyte0.98774444
97MP0009672_abnormal_birth_weight0.97908696
98MP0003183_abnormal_peptide_metabolism0.97112971
99MP0003121_genomic_imprinting0.96104641
100MP0003279_aneurysm0.95885907
101MP0002722_abnormal_immune_system0.95564712
102MP0004883_abnormal_blood_vessel0.94718976
103MP0000003_abnormal_adipose_tissue0.94100294
104MP0002168_other_aberrant_phenotype0.93213588
105MP0002723_abnormal_immune_serum0.93037595
106MP0001915_intracranial_hemorrhage0.92997556
107MP0002138_abnormal_hepatobiliary_system0.92712318
108MP0005623_abnormal_meninges_morphology0.91449713
109MP0002086_abnormal_extraembryonic_tissu0.91000784
110MP0003436_decreased_susceptibility_to0.90391345
111MP0003943_abnormal_hepatobiliary_system0.90325318
112MP0009053_abnormal_anal_canal0.89938280
113MP0002405_respiratory_system_inflammati0.89060684
114MP0000689_abnormal_spleen_morphology0.88782803
115MP0003385_abnormal_body_wall0.87438687
116MP0005174_abnormal_tail_pigmentation0.87060887
117MP0008469_abnormal_protein_level0.86904283
118MP0000432_abnormal_head_morphology0.85599718
119MP0005621_abnormal_cell_physiology0.85336038
120MP0002697_abnormal_eye_size0.84334099
121MP0001216_abnormal_epidermal_layer0.83804835
122MP0002088_abnormal_embryonic_growth/wei0.82534448
123MP0002092_abnormal_eye_morphology0.79917132
124MP0003984_embryonic_growth_retardation0.79795401
125MP0001784_abnormal_fluid_regulation0.79443439
126MP0002998_abnormal_bone_remodeling0.79309281
127MP0009840_abnormal_foam_cell0.79090269
128MP0008057_abnormal_DNA_replication0.79050037
129MP0000266_abnormal_heart_morphology0.78277930
130MP0009115_abnormal_fat_cell0.77677835
131MP0002429_abnormal_blood_cell0.77487932
132MP0003448_altered_tumor_morphology0.77260219
133MP0002132_abnormal_respiratory_system0.77187424
134MP0002128_abnormal_blood_circulation0.76925970
135MP0009931_abnormal_skin_appearance0.75530374
136MP0003656_abnormal_erythrocyte_physiolo0.74911575
137MP0005164_abnormal_response_to0.72196821
138MP0000249_abnormal_blood_vessel0.71902238
139MP0004130_abnormal_muscle_cell0.68584694
140MP0003795_abnormal_bone_structure0.67915414
141MP0005390_skeleton_phenotype0.67397160

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.60929120
2Abnormality of the fingertips (HP:0001211)4.50975826
3Recurrent bacterial skin infections (HP:0005406)3.35760581
4Recurrent abscess formation (HP:0002722)3.15539252
5Myositis (HP:0100614)3.04438337
6Macroorchidism (HP:0000053)2.88226607
7Broad face (HP:0000283)2.86835565
8Obstructive sleep apnea (HP:0002870)2.85533510
9Abnormality of macrophages (HP:0004311)2.80281401
10Orchitis (HP:0100796)2.79672783
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.78609976
12Short 4th metacarpal (HP:0010044)2.78609976
13Volvulus (HP:0002580)2.74118911
14Chronic mucocutaneous candidiasis (HP:0002728)2.70955252
15Recurrent cutaneous fungal infections (HP:0011370)2.70955252
16Long eyelashes (HP:0000527)2.69041020
17Meningitis (HP:0001287)2.64469129
18Gingivitis (HP:0000230)2.60342909
19Hematochezia (HP:0002573)2.59578618
20Gastrointestinal infarctions (HP:0005244)2.58906850
21Retrobulbar optic neuritis (HP:0100654)2.58446944
22Optic neuritis (HP:0100653)2.58446944
23Narrow palate (HP:0000189)2.58424572
24Absent frontal sinuses (HP:0002688)2.58002941
25Pustule (HP:0200039)2.56247601
26Abnormality of the nasal septum (HP:0000419)2.53308559
27Shallow orbits (HP:0000586)2.51166606
28Subacute progressive viral hepatitis (HP:0006572)2.48747718
29Recurrent skin infections (HP:0001581)2.48467407
30Vasculitis (HP:0002633)2.44980187
31Urethral obstruction (HP:0000796)2.44960908
32Mediastinal lymphadenopathy (HP:0100721)2.44241797
33Cerebral aneurysm (HP:0004944)2.43415284
34Hyperacusis (HP:0010780)2.41860255
35Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.40095573
36Aortic aneurysm (HP:0004942)2.36336272
37Panhypogammaglobulinemia (HP:0003139)2.31642254
38Elevated erythrocyte sedimentation rate (HP:0003565)2.28841474
39Flat acetabular roof (HP:0003180)2.27393590
40Slow saccadic eye movements (HP:0000514)2.25442871
41Syringomyelia (HP:0003396)2.24117132
42Spinal cord lesions (HP:0100561)2.24117132
43Recurrent gram-negative bacterial infections (HP:0005420)2.17669247
44Gastrointestinal stroma tumor (HP:0100723)2.16495531
45Lip pit (HP:0100267)2.14153873
46Chest pain (HP:0100749)2.12386482
47Agammaglobulinemia (HP:0004432)2.07650575
48Asymmetry of the thorax (HP:0001555)2.06573721
49Prolonged bleeding time (HP:0003010)2.06083050
50Rectal prolapse (HP:0002035)2.05240094
51Verrucae (HP:0200043)2.05023654
52Papilloma (HP:0012740)2.05023654
53Broad metatarsal (HP:0001783)2.03957694
54Abnormality of the 4th metacarpal (HP:0010012)2.02336218
55Elfin facies (HP:0004428)2.02242219
56Mitral valve prolapse (HP:0001634)2.00400992
57Enlarged penis (HP:0000040)1.98090687
58Interstitial pulmonary disease (HP:0006530)1.97169292
59Abnormal delayed hypersensitivity skin test (HP:0002963)1.96139154
60Viral hepatitis (HP:0006562)1.96051258
61Obstructive lung disease (HP:0006536)1.95996123
62Chronic obstructive pulmonary disease (HP:0006510)1.95996123
63Trigonocephaly (HP:0000243)1.95871486
64Recurrent viral infections (HP:0004429)1.95519854
65Keratoconjunctivitis sicca (HP:0001097)1.95179519
66Arterial thrombosis (HP:0004420)1.95044470
67Encephalitis (HP:0002383)1.94470160
68Renovascular hypertension (HP:0100817)1.92802055
69Spondylolisthesis (HP:0003302)1.89746338
70Emphysema (HP:0002097)1.89519655
71Deep philtrum (HP:0002002)1.89466015
72Limited elbow extension (HP:0001377)1.89192258
73Neoplasm of the adrenal cortex (HP:0100641)1.88808340
74Osteomyelitis (HP:0002754)1.88513928
75Transitional cell carcinoma of the bladder (HP:0006740)1.88493521
76Abnormality of T cells (HP:0002843)1.88301894
77Cellulitis (HP:0100658)1.87817825
78Pulmonary infiltrates (HP:0002113)1.87789655
79Truncal obesity (HP:0001956)1.87752871
80Obsessive-compulsive behavior (HP:0000722)1.87196098
81Aneurysm (HP:0002617)1.87138580
82Hemoptysis (HP:0002105)1.86965953
83Sparse lateral eyebrow (HP:0005338)1.86719042
84Segmental peripheral demyelination/remyelination (HP:0003481)1.86677606
85Recurrent bronchitis (HP:0002837)1.85729816
86Gastrointestinal carcinoma (HP:0002672)1.84487190
87Malignant gastrointestinal tract tumors (HP:0006749)1.84487190
88Thick eyebrow (HP:0000574)1.84342257
89Protrusio acetabuli (HP:0003179)1.83678580
90Thin bony cortex (HP:0002753)1.83361974
91Colitis (HP:0002583)1.82944254
92Papilledema (HP:0001085)1.82759631
93Bowel diverticulosis (HP:0005222)1.82640546
94Stomatitis (HP:0010280)1.81623694
95Inflammation of the large intestine (HP:0002037)1.81564127
96Epistaxis (HP:0000421)1.81545557
97Gastrointestinal inflammation (HP:0004386)1.81415362
98Broad thumb (HP:0011304)1.80023679
99Persistence of primary teeth (HP:0006335)1.79613977
100Dislocated radial head (HP:0003083)1.79589171
101Supernumerary ribs (HP:0005815)1.79447438
102Lymphopenia (HP:0001888)1.79143112
103Increased density of long bones (HP:0006392)1.79067582
104Neonatal hypoglycemia (HP:0001998)1.78633080
105Dysmetric saccades (HP:0000641)1.78257304
106Urticaria (HP:0001025)1.78055977
107Milia (HP:0001056)1.77919000
108Abnormality of cells of the lymphoid lineage (HP:0012140)1.77901837
109Distal lower limb amyotrophy (HP:0008944)1.77687536
110Heterotopia (HP:0002282)1.77683188
111Acute myeloid leukemia (HP:0004808)1.77511880
112Ankle contracture (HP:0006466)1.77368755
113Recurrent fungal infections (HP:0002841)1.77339240
114T lymphocytopenia (HP:0005403)1.76567052
115Vertebral arch anomaly (HP:0008438)1.76480079
116Autoimmune hemolytic anemia (HP:0001890)1.76273083
117Smooth philtrum (HP:0000319)1.76017915
118Restrictive lung disease (HP:0002091)1.75216387
119Leiomyosarcoma (HP:0100243)1.74714914
120Uterine leiomyosarcoma (HP:0002891)1.74714914
121Fatigue (HP:0012378)1.74298075
122Metaphyseal cupping (HP:0003021)1.74017920
123Granulocytopenia (HP:0001913)1.73628025
124Increased nuchal translucency (HP:0010880)1.73401096
125Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.73250043
126Abnormality of the columella (HP:0009929)1.73124590
127Germ cell neoplasia (HP:0100728)1.72590593
128Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.72221511
129Bladder carcinoma (HP:0002862)1.72092925
130Bladder neoplasm (HP:0009725)1.72092925
131Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.71457445
132Aortic dissection (HP:0002647)1.69443484
133Ulnar bowing (HP:0003031)1.69411805
134Keratoconjunctivitis (HP:0001096)1.69335609
135Polygenic inheritance (HP:0010982)1.69202592
136Skin ulcer (HP:0200042)1.68874890
137Abnormality of the radial head (HP:0003995)1.68296177
138Gingival bleeding (HP:0000225)1.67942500
139Increased connective tissue (HP:0009025)1.67588105
140Spontaneous hematomas (HP:0007420)1.67436589
141Abnormality of T cell number (HP:0011839)1.67407480
142Abnormality of the peritoneum (HP:0002585)1.67217650
143Periodontitis (HP:0000704)1.66882359
144Osteolytic defects of the phalanges of the hand (HP:0009771)1.66469539
145Osteolytic defects of the hand bones (HP:0009699)1.66469539
146Dilatation of the ascending aorta (HP:0005111)1.66114356
147Hypoplastic ischia (HP:0003175)1.65852884
148Abnormality of the thoracic spine (HP:0100711)1.65609422
149Atrophic scars (HP:0001075)1.64369748
150Ureteral obstruction (HP:0006000)1.63952156
151Cutis marmorata (HP:0000965)1.61702166
152Broad palm (HP:0001169)1.61432372
153Bladder diverticulum (HP:0000015)1.61038565
154Low anterior hairline (HP:0000294)1.60760850
155Abnormality of the distal phalanx of the thumb (HP:0009617)1.60016358
156Disproportionate tall stature (HP:0001519)1.57685874
157Pseudobulbar signs (HP:0002200)1.57359193
158Thyroiditis (HP:0100646)1.57273124
159Exostoses (HP:0100777)1.56952694
160Renal duplication (HP:0000075)1.56898148
161Abnormality of the parietal bone (HP:0002696)1.55890064
162Myocardial infarction (HP:0001658)1.54432224
163Abnormality of the frontal sinuses (HP:0002687)1.54286554
164Ureteral stenosis (HP:0000071)1.52905072
165Abnormality of the intervertebral disk (HP:0005108)1.51540241
166Increased IgE level (HP:0003212)1.51414707
167Autoimmune thrombocytopenia (HP:0001973)1.51202542
168Hypoplasia of the maxilla (HP:0000327)1.50739549

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.35433252
2PRPF4B3.72928322
3BRD42.65705964
4RIPK42.59031798
5FGFR32.33670381
6SMG12.31630138
7CAMK1D2.28805707
8CAMK1G2.20026615
9MAP3K102.17788538
10LATS12.15985841
11SIK12.13612466
12EEF2K2.10086889
13TRIB31.98556235
14MAP3K131.93420113
15MAP4K11.88329864
16STK101.77694272
17PTK61.73048413
18PKN21.71107327
19EPHA31.66404702
20BLK1.64894474
21FRK1.64059870
22IRAK41.57669026
23JAK11.57083547
24RIPK11.54422491
25TTN1.53593298
26FGFR41.52655229
27DMPK1.51693713
28SIK31.43691135
29FGFR21.42322685
30SIK21.34951810
31CDK61.34326984
32SGK31.33266344
33ERN11.32202257
34EPHB11.31531298
35TAOK11.31148310
36STK31.31013383
37TGFBR21.28973000
38INSRR1.28823742
39MTOR1.26512808
40TAOK31.23169573
41TYK21.22617674
42PDGFRA1.21957830
43CHUK1.21851486
44MAP3K31.20253550
45JAK31.12321270
46TBK11.10095280
47MAP3K71.05763539
48MAP3K11.05523137
49FES1.05496000
50NUAK11.05320752
51PDGFRB1.05270834
52ALK1.04921893
53CDK91.04550098
54WNK11.00007369
55CLK10.97967380
56HCK0.93646555
57SGK20.92469614
58KSR20.92234715
59ITK0.91915103
60MAP2K30.90881252
61CSF1R0.89901346
62HIPK20.89774362
63BMX0.89527254
64MAP3K140.89261858
65PRKCH0.88024347
66TRPM70.87011769
67BTK0.83881065
68PRKD20.83453976
69DYRK1B0.82547646
70LRRK20.81554119
71PIM10.80490982
72SYK0.80397466
73IRAK30.79511940
74PDPK10.79509732
75CSK0.78934541
76PDK10.78872155
77IRAK10.78133472
78MARK30.77720600
79MAP3K20.74353104
80MARK20.73800519
81IKBKE0.73248681
82TAOK20.73164982
83YES10.72101056
84STK40.71327999
85CAMKK10.71086161
86MAPK120.70499086
87CDC42BPA0.70260814
88RPS6KA40.69685689
89CDK40.69684370
90NEK90.69364377
91PAK20.69319628
92IRAK20.68439615
93MAPK110.68036072
94FGR0.67841338
95TXK0.63638187
96KIT0.62007925
97STK380.61122535
98ICK0.60900847
99MAPK70.60814521
100ZAP700.60362038
101EPHA20.60073061
102FGFR10.59902907
103MELK0.59216369
104MAP2K20.58268432
105PASK0.57730926
106ATR0.57440323
107MAP3K60.56978703
108NLK0.56962063
109PTK20.56614564
110LCK0.56028460
111FLT30.55462547
112RPS6KB20.54627448
113JAK20.54436901
114ATM0.54321665
115NEK20.54299537
116LYN0.53507631
117RET0.53262134
118RPS6KC10.53106123
119RPS6KL10.53106123
120IKBKB0.52689345
121PRKAA20.52319306
122RPS6KA20.52084734
123TNK20.50526572
124CHEK10.48993026
125CAMK40.47708659
126MAPK10.45620504
127MAPK140.45377683
128GRK60.45274883
129PRKD10.45072736
130DDR20.43437741
131MAPK80.42849743
132ZAK0.41664254
133AKT10.41415846
134CSNK1D0.40429444
135RPS6KA60.39500330

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.29336530
2B cell receptor signaling pathway_Homo sapiens_hsa046622.01151131
3Chronic myeloid leukemia_Homo sapiens_hsa052201.83321336
4Primary immunodeficiency_Homo sapiens_hsa053401.79893634
5Adherens junction_Homo sapiens_hsa045201.57591269
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.56963580
7Other glycan degradation_Homo sapiens_hsa005111.51539837
8Small cell lung cancer_Homo sapiens_hsa052221.50400708
9MicroRNAs in cancer_Homo sapiens_hsa052061.47695779
10Osteoclast differentiation_Homo sapiens_hsa043801.44374356
11Acute myeloid leukemia_Homo sapiens_hsa052211.44127813
12Proteoglycans in cancer_Homo sapiens_hsa052051.36834433
13Allograft rejection_Homo sapiens_hsa053301.36531847
14Endometrial cancer_Homo sapiens_hsa052131.35377107
15T cell receptor signaling pathway_Homo sapiens_hsa046601.34648764
16Transcriptional misregulation in cancer_Homo sapiens_hsa052021.33357146
17Graft-versus-host disease_Homo sapiens_hsa053321.32545021
18Toxoplasmosis_Homo sapiens_hsa051451.29859490
19Focal adhesion_Homo sapiens_hsa045101.29762919
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29751850
21Autoimmune thyroid disease_Homo sapiens_hsa053201.27750480
22Notch signaling pathway_Homo sapiens_hsa043301.26763632
23Non-small cell lung cancer_Homo sapiens_hsa052231.26245337
24Prostate cancer_Homo sapiens_hsa052151.26244081
25Pancreatic cancer_Homo sapiens_hsa052121.24066345
26Staphylococcus aureus infection_Homo sapiens_hsa051501.22911925
27Leishmaniasis_Homo sapiens_hsa051401.22542121
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.21626301
29Measles_Homo sapiens_hsa051621.20082607
30Dorso-ventral axis formation_Homo sapiens_hsa043201.19674914
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16393349
32Insulin resistance_Homo sapiens_hsa049311.15724860
33Viral myocarditis_Homo sapiens_hsa054161.15708656
34Type II diabetes mellitus_Homo sapiens_hsa049301.13843572
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13651747
36ECM-receptor interaction_Homo sapiens_hsa045121.12773019
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12757491
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10367824
39Prolactin signaling pathway_Homo sapiens_hsa049171.10249641
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.09974907
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.08520898
42Platelet activation_Homo sapiens_hsa046111.06422708
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05342523
44HTLV-I infection_Homo sapiens_hsa051661.05212329
45Hematopoietic cell lineage_Homo sapiens_hsa046401.05055744
46Hepatitis B_Homo sapiens_hsa051611.04262732
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03813450
48Antigen processing and presentation_Homo sapiens_hsa046121.02361455
49FoxO signaling pathway_Homo sapiens_hsa040681.01982734
50Herpes simplex infection_Homo sapiens_hsa051681.01175094
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.00990860
52Chemokine signaling pathway_Homo sapiens_hsa040621.00826923
53Glioma_Homo sapiens_hsa052141.00637697
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99887424
55GnRH signaling pathway_Homo sapiens_hsa049120.99605412
56mTOR signaling pathway_Homo sapiens_hsa041500.99589737
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98296849
58TNF signaling pathway_Homo sapiens_hsa046680.96953858
59Colorectal cancer_Homo sapiens_hsa052100.95656147
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95050205
61Viral carcinogenesis_Homo sapiens_hsa052030.94529028
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94010627
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93873382
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93018262
65Basal cell carcinoma_Homo sapiens_hsa052170.92827239
66Malaria_Homo sapiens_hsa051440.92621587
67Pathways in cancer_Homo sapiens_hsa052000.86910347
68Influenza A_Homo sapiens_hsa051640.85346874
69Type I diabetes mellitus_Homo sapiens_hsa049400.84424488
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83866917
71Amoebiasis_Homo sapiens_hsa051460.83467015
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83431392
73Inositol phosphate metabolism_Homo sapiens_hsa005620.82806562
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82340069
75Renal cell carcinoma_Homo sapiens_hsa052110.82274171
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80208548
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79018851
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78687803
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77807583
80Epstein-Barr virus infection_Homo sapiens_hsa051690.76265882
81Apoptosis_Homo sapiens_hsa042100.75960162
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.75034139
83TGF-beta signaling pathway_Homo sapiens_hsa043500.74733738
84Hepatitis C_Homo sapiens_hsa051600.74453704
85Legionellosis_Homo sapiens_hsa051340.73523924
86ErbB signaling pathway_Homo sapiens_hsa040120.72642172
87Insulin signaling pathway_Homo sapiens_hsa049100.71351397
88Wnt signaling pathway_Homo sapiens_hsa043100.71186140
89MAPK signaling pathway_Homo sapiens_hsa040100.69301148
90Rap1 signaling pathway_Homo sapiens_hsa040150.69168187
91Endocytosis_Homo sapiens_hsa041440.67080739
92Hippo signaling pathway_Homo sapiens_hsa043900.65633377
93Choline metabolism in cancer_Homo sapiens_hsa052310.64783700
94Long-term potentiation_Homo sapiens_hsa047200.63827320
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63600416
96Protein digestion and absorption_Homo sapiens_hsa049740.63048333
97mRNA surveillance pathway_Homo sapiens_hsa030150.63005238
98AMPK signaling pathway_Homo sapiens_hsa041520.62557217
99Melanoma_Homo sapiens_hsa052180.62045782
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61745242
101Estrogen signaling pathway_Homo sapiens_hsa049150.61630097
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61391461
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61214505
104VEGF signaling pathway_Homo sapiens_hsa043700.60903478
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.59349084
106Pertussis_Homo sapiens_hsa051330.58828153
107Dilated cardiomyopathy_Homo sapiens_hsa054140.58122523
108Thyroid cancer_Homo sapiens_hsa052160.57825877
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57671093
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56096964
111ABC transporters_Homo sapiens_hsa020100.55996742
112Bladder cancer_Homo sapiens_hsa052190.55944148
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.55161518
114HIF-1 signaling pathway_Homo sapiens_hsa040660.54896114
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.54401121
116African trypanosomiasis_Homo sapiens_hsa051430.54328807
117Shigellosis_Homo sapiens_hsa051310.52142935
118Tuberculosis_Homo sapiens_hsa051520.51806207

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