KCTD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the potassium channel tetramerization-domain containing (KCTD) protein family. Members of this protein family regulate the biophysical characteristics of ion channels. In mouse, this protein interacts with hyperpolarization-activated cyclic nucleotide-gated channel complex 3 and enhances its cell surface expression and current density. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.08780528
2central nervous system myelination (GO:0022010)7.08780528
3long-chain fatty acid biosynthetic process (GO:0042759)4.26410029
4establishment of mitochondrion localization (GO:0051654)3.71070105
5myelination (GO:0042552)3.67712796
6nuclear pore complex assembly (GO:0051292)3.64796440
7ensheathment of neurons (GO:0007272)3.62661426
8axon ensheathment (GO:0008366)3.62661426
9neuron cell-cell adhesion (GO:0007158)3.37739605
10paraxial mesoderm development (GO:0048339)3.34422491
11nuclear pore organization (GO:0006999)3.34250833
12microtubule polymerization or depolymerization (GO:0031109)3.32269638
13desmosome organization (GO:0002934)3.22150124
14glycerophospholipid catabolic process (GO:0046475)3.18274778
15protein K6-linked ubiquitination (GO:0085020)3.13595018
16Golgi transport vesicle coating (GO:0048200)3.11274100
17COPI coating of Golgi vesicle (GO:0048205)3.11274100
18protein neddylation (GO:0045116)3.09057736
19mitotic sister chromatid cohesion (GO:0007064)3.06171713
20biotin metabolic process (GO:0006768)3.06002737
21DNA unwinding involved in DNA replication (GO:0006268)3.02809575
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.97918951
23presynaptic membrane organization (GO:0097090)2.97406372
24piRNA metabolic process (GO:0034587)2.94965382
25neurotransmitter uptake (GO:0001504)2.94285670
26negative regulation of protein localization to cell surface (GO:2000009)2.90829262
27startle response (GO:0001964)2.89196022
28embryonic retina morphogenesis in camera-type eye (GO:0060059)2.87636591
29negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.84916811
30proline biosynthetic process (GO:0006561)2.80807561
31negative regulation of neurotransmitter transport (GO:0051589)2.80547393
32regulation of collateral sprouting (GO:0048670)2.78411192
33cerebral cortex radially oriented cell migration (GO:0021799)2.76346725
34fatty acid elongation (GO:0030497)2.75409876
35neuron recognition (GO:0008038)2.74674709
36DNA damage induced protein phosphorylation (GO:0006975)2.71030687
37hormone catabolic process (GO:0042447)2.70456686
38L-amino acid import (GO:0043092)2.69595980
39COPII vesicle coating (GO:0048208)2.69557467
40presynaptic membrane assembly (GO:0097105)2.69505702
41DNA methylation involved in gamete generation (GO:0043046)2.69008864
42mitotic chromosome condensation (GO:0007076)2.67135166
43regulation of exit from mitosis (GO:0007096)2.65361030
44response to redox state (GO:0051775)2.61734458
45myelin maintenance (GO:0043217)2.59949324
46notochord development (GO:0030903)2.58143483
47transmission of nerve impulse (GO:0019226)2.56001189
48regulation of translational fidelity (GO:0006450)2.55724315
49regulation of mitotic spindle organization (GO:0060236)2.55595010
50centriole replication (GO:0007099)2.54901264
51establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.52358311
52mitochondrion transport along microtubule (GO:0047497)2.52358311
53maturation of 5.8S rRNA (GO:0000460)2.52108138
54regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.51558588
55negative regulation of execution phase of apoptosis (GO:1900118)2.50659403
56neuronal action potential propagation (GO:0019227)2.48665403
57adult walking behavior (GO:0007628)2.48472656
58photoreceptor cell differentiation (GO:0046530)2.48307451
59eye photoreceptor cell differentiation (GO:0001754)2.48307451
60regulation of centriole replication (GO:0046599)2.48289678
617-methylguanosine mRNA capping (GO:0006370)2.47624697
62apical protein localization (GO:0045176)2.47066222
63microtubule severing (GO:0051013)2.45651875
64protein retention in ER lumen (GO:0006621)2.45019385
65bundle of His cell to Purkinje myocyte communication (GO:0086069)2.44937582
667-methylguanosine RNA capping (GO:0009452)2.44433307
67RNA capping (GO:0036260)2.44433307
68synaptic transmission, glutamatergic (GO:0035249)2.44322789
69intestinal epithelial cell development (GO:0060576)2.44034667
70positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.44025211
71glutamine family amino acid biosynthetic process (GO:0009084)2.42965885
72oligodendrocyte differentiation (GO:0048709)2.42887920
73maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.42758972
74mitotic metaphase plate congression (GO:0007080)2.42636286
75regulation of meiosis I (GO:0060631)2.41577934
76positive regulation of neurological system process (GO:0031646)2.41427834
77dendritic spine morphogenesis (GO:0060997)2.40595487
78deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.40429435
79axonal fasciculation (GO:0007413)2.39408622
80positive regulation of oligodendrocyte differentiation (GO:0048714)2.38780197
81positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.38557331
82pore complex assembly (GO:0046931)2.38423433
83ionotropic glutamate receptor signaling pathway (GO:0035235)2.37762290
84preassembly of GPI anchor in ER membrane (GO:0016254)2.36795532
85gap junction assembly (GO:0016264)2.36230649
86proline metabolic process (GO:0006560)2.36173587
87cellular protein complex localization (GO:0034629)2.36156360
88righting reflex (GO:0060013)2.35526970
89hippo signaling (GO:0035329)2.34666289
90termination of RNA polymerase III transcription (GO:0006386)2.34510985
91transcription elongation from RNA polymerase III promoter (GO:0006385)2.34510985
92regulation of gene silencing by RNA (GO:0060966)2.33388422
93regulation of posttranscriptional gene silencing (GO:0060147)2.33388422
94regulation of gene silencing by miRNA (GO:0060964)2.33388422
95regulation of nuclear cell cycle DNA replication (GO:0033262)2.32555634
96prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.32539910
97neuron-neuron synaptic transmission (GO:0007270)2.30870548
98urea metabolic process (GO:0019627)2.29738881
99regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.29685369
100limb bud formation (GO:0060174)2.28306566
101isoprenoid biosynthetic process (GO:0008299)2.27905993
102regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.27586435
103ribosome assembly (GO:0042255)2.27232728
104planar cell polarity pathway involved in neural tube closure (GO:0090179)2.26898767
105regulation of bile acid biosynthetic process (GO:0070857)2.26114059
106protein localization to synapse (GO:0035418)2.25381691
107midgut development (GO:0007494)2.24002245
108urea cycle (GO:0000050)2.23857903
109cellular modified amino acid catabolic process (GO:0042219)2.23409372
110embryonic camera-type eye morphogenesis (GO:0048596)2.22263388
111histone H2B ubiquitination (GO:0033523)2.21452869
112sister chromatid segregation (GO:0000819)2.21373861
113microtubule depolymerization (GO:0007019)2.21335719
114branching involved in mammary gland duct morphogenesis (GO:0060444)2.21302071
115regulation of glucose import in response to insulin stimulus (GO:2001273)2.21223744
116NLS-bearing protein import into nucleus (GO:0006607)2.20895823
117proteasome assembly (GO:0043248)2.20400268
118regulation of short-term neuronal synaptic plasticity (GO:0048172)2.20366020
119centriole assembly (GO:0098534)2.19606808
120regulation of RNA export from nucleus (GO:0046831)2.19601203
121establishment of spindle orientation (GO:0051294)2.19388837
122protein complex localization (GO:0031503)2.18240048
123positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.17200747
124negative regulation of synaptic transmission, GABAergic (GO:0032229)2.16825075
125establishment of apical/basal cell polarity (GO:0035089)2.16286191
126regulation of synapse maturation (GO:0090128)2.16186736
127amino acid import (GO:0043090)2.16121381
128asymmetric protein localization (GO:0008105)2.15570961
129glutamate receptor signaling pathway (GO:0007215)2.15292963
130protein polyglutamylation (GO:0018095)2.14477260
131synaptonemal complex assembly (GO:0007130)2.13371053
132pre-miRNA processing (GO:0031054)2.13226012
133epithelial cell-cell adhesion (GO:0090136)2.11221553
134transcription from RNA polymerase I promoter (GO:0006360)2.11216945
135otic vesicle formation (GO:0030916)2.11201525
136dendrite development (GO:0016358)2.10966909
137glycine transport (GO:0015816)2.10214009
138negative regulation of neurotransmitter secretion (GO:0046929)2.10084338
139cell fate commitment involved in formation of primary germ layer (GO:0060795)2.09794442
140regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.09485021
141synaptic vesicle maturation (GO:0016188)2.08670059
142regulation of double-strand break repair via homologous recombination (GO:0010569)2.08584103
143transcription elongation from RNA polymerase I promoter (GO:0006362)2.08422992
144regulation of feeding behavior (GO:0060259)2.07754192
145adult locomotory behavior (GO:0008344)2.06984964
146regulation of centrosome duplication (GO:0010824)2.06771165
147GPI anchor biosynthetic process (GO:0006506)2.06689090
148cholesterol biosynthetic process (GO:0006695)2.06026790
149cellular zinc ion homeostasis (GO:0006882)2.05804373
150dicarboxylic acid biosynthetic process (GO:0043650)2.05687988
151epithelial cell maturation (GO:0002070)2.05617797
152body morphogenesis (GO:0010171)2.05517604
153cytoskeletal anchoring at plasma membrane (GO:0007016)2.05375467
154histone H4-K12 acetylation (GO:0043983)2.04724300
155vesicle coating (GO:0006901)2.03638830
156anterior/posterior axis specification, embryo (GO:0008595)2.02625792
157regulation of centrosome cycle (GO:0046605)2.01938566
158embryonic eye morphogenesis (GO:0048048)2.01505195
159ectodermal placode formation (GO:0060788)2.01034592
160mitotic sister chromatid segregation (GO:0000070)2.00665993
161retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)1.99758155
162regulation of nucleobase-containing compound transport (GO:0032239)1.98507275
163regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.97830195
164tight junction assembly (GO:0070830)1.97378880
165protein localization to microtubule (GO:0035372)1.96954657
166chaperone-mediated protein complex assembly (GO:0051131)1.96533330
167epithelial tube branching involved in lung morphogenesis (GO:0060441)1.95828682
168regulation of cholesterol biosynthetic process (GO:0045540)1.95324020
169insulin-like growth factor receptor signaling pathway (GO:0048009)1.95161755
170purine nucleotide transport (GO:0015865)1.95042994
171L-phenylalanine metabolic process (GO:0006558)1.94063176
172erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)1.94063176
173mitotic cytokinesis (GO:0000281)1.93407397
174cell-cell junction assembly (GO:0007043)1.93231658
175Wnt signaling pathway, planar cell polarity pathway (GO:0060071)1.92542902
176phenol-containing compound catabolic process (GO:0019336)1.91569529
177cellular glucuronidation (GO:0052695)1.91070331
178convergent extension (GO:0060026)1.90918545
179embryonic foregut morphogenesis (GO:0048617)1.90567321
180negative regulation of DNA repair (GO:0045738)1.90253037
181glucocorticoid biosynthetic process (GO:0006704)1.90168570
182dichotomous subdivision of an epithelial terminal unit (GO:0060600)1.89997289
183L-serine metabolic process (GO:0006563)1.88150074
184intestinal absorption (GO:0050892)1.87969711
185intestinal cholesterol absorption (GO:0030299)1.87908763
186DNA topological change (GO:0006265)1.87376588
187establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)1.86663907
188negative regulation of fatty acid transport (GO:2000192)1.86481406
189positive regulation of chromosome segregation (GO:0051984)1.85424946
190mammary gland alveolus development (GO:0060749)1.85089905
191glucocorticoid metabolic process (GO:0008211)1.83776392
192regulation of establishment of planar polarity (GO:0090175)1.83436964
193glutamate metabolic process (GO:0006536)1.83424106
194negative regulation of keratinocyte proliferation (GO:0010839)1.83419248
195maternal placenta development (GO:0001893)1.82649031

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.99732893
2* AR_21909140_ChIP-Seq_LNCAP_Human3.59643249
3ESR1_15608294_ChIP-ChIP_MCF-7_Human3.28064715
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.16034361
5ESR1_20079471_ChIP-ChIP_T-47D_Human3.10278272
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.85075636
7GBX2_23144817_ChIP-Seq_PC3_Human2.74097447
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55655057
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.53754016
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.47736207
11CLOCK_20551151_ChIP-Seq_293T_Human2.46663609
12* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.26571832
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.25271731
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.16761908
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09327628
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.09061127
17PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.07293231
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.03678551
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.99432804
20FUS_26573619_Chip-Seq_HEK293_Human1.97691912
21ZNF263_19887448_ChIP-Seq_K562_Human1.97332356
22TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.95552669
23GATA1_26923725_Chip-Seq_HPCs_Mouse1.90678537
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.90601935
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.84509505
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.84509505
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.84509505
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75311305
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70403315
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69613290
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.68159168
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68113872
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.67822091
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64982247
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.64965074
36VDR_22108803_ChIP-Seq_LS180_Human1.62335954
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59549963
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.59431300
39AHR_22903824_ChIP-Seq_MCF-7_Human1.56585182
40* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55895806
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.55657695
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53323065
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.51162905
44RNF2_27304074_Chip-Seq_NSC_Mouse1.50990935
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47118518
46* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.46829594
47IGF1R_20145208_ChIP-Seq_DFB_Human1.45477697
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44885183
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44811312
50REST_21632747_ChIP-Seq_MESCs_Mouse1.44251504
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43984365
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43964522
53* GATA3_24758297_ChIP-Seq_MCF-7_Human1.43297588
54SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42609475
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42152115
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41883304
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39123815
58* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38624234
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36874334
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.36028892
61* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35623885
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34293222
63SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31752928
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31228422
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31228422
66* ER_23166858_ChIP-Seq_MCF-7_Human1.30536287
67* CHD1_26751641_Chip-Seq_LNCaP_Human1.29946054
68* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29873185
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.29242577
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29107591
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28350899
72EWS_26573619_Chip-Seq_HEK293_Human1.28024034
73* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27794746
74AR_21572438_ChIP-Seq_LNCaP_Human1.27337440
75NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27045421
76TAF15_26573619_Chip-Seq_HEK293_Human1.26748355
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26314642
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.25675555
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.25576975
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25303045
81* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25211376
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24883038
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.23371656
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.22383814
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22224772
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21265160
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20174070
88JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17860692
89* GATA6_25053715_ChIP-Seq_YYC3_Human1.16068914
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16044124
91* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.14975967
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13477415
93REST_18959480_ChIP-ChIP_MESCs_Mouse1.13026382
94* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12756966
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.12586282
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11407290
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11296527
98* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11160950
99RXR_22158963_ChIP-Seq_LIVER_Mouse1.10965145
100SOX17_20123909_ChIP-Seq_XEN_Mouse1.10347182
101HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10210998
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10143130
103LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10088927
104LXR_22158963_ChIP-Seq_LIVER_Mouse1.09856637
105SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09455548
106* SMAD3_21741376_ChIP-Seq_EPCs_Human1.09308328
107EZH2_27294783_Chip-Seq_ESCs_Mouse1.09158160
108CDX2_20551321_ChIP-Seq_CACO-2_Human1.09065827
109* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08761542
110PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08247645
111P300_19829295_ChIP-Seq_ESCs_Human1.07855718
112RUNX1_27514584_Chip-Seq_MCF-7_Human1.07574932
113RARB_27405468_Chip-Seq_BRAIN_Mouse1.07350367
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07036921
115SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06891131
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06378217
117* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06113877
118THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06034151
119NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05838976
120* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04508137
121* STAT3_23295773_ChIP-Seq_U87_Human1.04252764
122RACK7_27058665_Chip-Seq_MCF-7_Human1.04238838
123* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03734951
124WT1_19549856_ChIP-ChIP_CCG9911_Human1.03676359
125E2F4_17652178_ChIP-ChIP_JURKAT_Human1.03530169
126* FOXA2_19822575_ChIP-Seq_HepG2_Human1.03161192
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02910131
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02435463
129E2F7_22180533_ChIP-Seq_HELA_Human1.02261982
130EST1_17652178_ChIP-ChIP_JURKAT_Human1.01967590
131CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01890764
132* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01264865
133SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01127677
134YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00291999
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99366384
136SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98846225
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98606844
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98026776
139EGR1_19374776_ChIP-ChIP_THP-1_Human0.97200724
140GABP_17652178_ChIP-ChIP_JURKAT_Human0.97120223
141* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97013830
142TCF4_23295773_ChIP-Seq_U87_Human0.96993786
143* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96869513
144* NANOG_18555785_Chip-Seq_ESCs_Mouse0.95973692
145TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95961936
146* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95881619
147* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.95370213
148POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95291189
149TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95291189
150SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95052171
151* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95005386
152* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94838885
153SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94464994
154CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94373140
155CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94173426
156* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94066140
157CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94059548
158TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93687713
159CREB1_15753290_ChIP-ChIP_HEK293T_Human0.93441291
160MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93042460
161* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92326952
162PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92118222
163* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91865411
164* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91832282
165RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91690097
166PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91601138
167CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91317836
168ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91306563
169NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91275506
170* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90716825
171HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90130821
172KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89870947
173RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89704530
174SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89634122
175EP300_21415370_ChIP-Seq_HL-1_Mouse0.89576041
176NANOG_21062744_ChIP-ChIP_HESCs_Human0.88879133
177PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87248048
178RING1B_27294783_Chip-Seq_NPCs_Mouse0.87122074
179* FOXA1_25552417_ChIP-Seq_VCAP_Human0.87071759
180PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86945861
181TCF4_18268006_ChIP-ChIP_LS174T_Human0.86893425
182* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86771591
183* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86771591
184* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86676198
185ISL1_27105846_Chip-Seq_CPCs_Mouse0.86143738
186TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85942222
187HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85367205
188PKCTHETA_26484144_Chip-Seq_BREAST_Human0.85160778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.72870322
2MP0003941_abnormal_skin_development2.99474675
3MP0010234_abnormal_vibrissa_follicle2.98894191
4MP0004270_analgesia2.78456463
5MP0004859_abnormal_synaptic_plasticity2.68851490
6MP0005423_abnormal_somatic_nervous2.48256464
7MP0008877_abnormal_DNA_methylation2.48250238
8MP0001529_abnormal_vocalization2.30973923
9MP0003705_abnormal_hypodermis_morpholog2.28323325
10MP0009780_abnormal_chondrocyte_physiolo2.22091163
11MP0000778_abnormal_nervous_system2.16463688
12MP0001486_abnormal_startle_reflex2.10541790
13MP0003136_yellow_coat_color2.10071916
14MP0000537_abnormal_urethra_morphology2.02155702
15MP0003635_abnormal_synaptic_transmissio2.01039659
16MP0002272_abnormal_nervous_system2.00244902
17MP0003787_abnormal_imprinting1.95980748
18MP0000920_abnormal_myelination1.95801880
19MP0001905_abnormal_dopamine_level1.95318072
20MP0006292_abnormal_olfactory_placode1.94961183
21MP0004264_abnormal_extraembryonic_tissu1.94122129
22MP0003868_abnormal_feces_composition1.90201735
23MP0004885_abnormal_endolymph1.89031012
24MP0002734_abnormal_mechanical_nocicepti1.83122854
25MP0005171_absent_coat_pigmentation1.81576631
26MP0002653_abnormal_ependyma_morphology1.79289325
27MP0005409_darkened_coat_color1.77314856
28MP0009745_abnormal_behavioral_response1.73121171
29MP0010352_gastrointestinal_tract_polyps1.72311393
30MP0002063_abnormal_learning/memory/cond1.69123763
31MP0002877_abnormal_melanocyte_morpholog1.68791116
32MP0001485_abnormal_pinna_reflex1.68607341
33MP0002064_seizures1.66970962
34MP0004133_heterotaxia1.63480796
35MP0002796_impaired_skin_barrier1.63471287
36MP0010678_abnormal_skin_adnexa1.62453144
37MP0004742_abnormal_vestibular_system1.61172600
38MP0001188_hyperpigmentation1.59803797
39MP0002009_preneoplasia1.58979866
40MP0008789_abnormal_olfactory_epithelium1.58807840
41MP0001666_abnormal_nutrient_absorption1.57409017
42MP0002572_abnormal_emotion/affect_behav1.56091071
43MP0005248_abnormal_Harderian_gland1.55220721
44MP0002697_abnormal_eye_size1.54427777
45MP0005499_abnormal_olfactory_system1.54099176
46MP0005394_taste/olfaction_phenotype1.54099176
47MP0000579_abnormal_nail_morphology1.51628985
48MP0003718_maternal_effect1.51537202
49MP0008057_abnormal_DNA_replication1.47701747
50MP0004185_abnormal_adipocyte_glucose1.47486426
51MP0004272_abnormal_basement_membrane1.45599262
52MP0004233_abnormal_muscle_weight1.43208434
53MP0003111_abnormal_nucleus_morphology1.42021274
54MP0000955_abnormal_spinal_cord1.41172874
55MP0003121_genomic_imprinting1.40794610
56MP0003937_abnormal_limbs/digits/tail_de1.39448077
57MP0004142_abnormal_muscle_tone1.38720203
58MP0000566_synostosis1.38101724
59MP0002184_abnormal_innervation1.36387322
60MP0005645_abnormal_hypothalamus_physiol1.35963407
61MP0009672_abnormal_birth_weight1.35526696
62MP0003632_abnormal_nervous_system1.35252268
63MP0000383_abnormal_hair_follicle1.33398085
64MP0008438_abnormal_cutaneous_collagen1.32854769
65MP0009046_muscle_twitch1.32017518
66MP0000762_abnormal_tongue_morphology1.31924496
67MP0002882_abnormal_neuron_morphology1.31883636
68MP0003890_abnormal_embryonic-extraembry1.29477436
69MP0005076_abnormal_cell_differentiation1.29442096
70MP0005257_abnormal_intraocular_pressure1.27926845
71MP0005408_hypopigmentation1.27769852
72MP0001881_abnormal_mammary_gland1.27744140
73MP0009697_abnormal_copulation1.26678159
74MP0003950_abnormal_plasma_membrane1.26081951
75MP0010030_abnormal_orbit_morphology1.24934257
76MP0002102_abnormal_ear_morphology1.24813011
77MP0006276_abnormal_autonomic_nervous1.24773481
78MP0003123_paternal_imprinting1.24046785
79MP0003861_abnormal_nervous_system1.23426737
80MP0004782_abnormal_surfactant_physiolog1.23051377
81MP0002254_reproductive_system_inflammat1.21956817
82MP0000627_abnormal_mammary_gland1.21877049
83MP0003942_abnormal_urinary_system1.21595521
84MP0003283_abnormal_digestive_organ1.21447210
85MP0002752_abnormal_somatic_nervous1.21348108
86MP0001440_abnormal_grooming_behavior1.21336015
87MP0009053_abnormal_anal_canal1.21305002
88MP0008058_abnormal_DNA_repair1.21156744
89MP0003315_abnormal_perineum_morphology1.20874272
90MP0002152_abnormal_brain_morphology1.19547347
91MP0002735_abnormal_chemical_nociception1.19143796
92MP0001963_abnormal_hearing_physiology1.18217213
93MP0000534_abnormal_ureter_morphology1.18081394
94MP0009384_cardiac_valve_regurgitation1.17996435
95MP0002098_abnormal_vibrissa_morphology1.15106918
96MP0002067_abnormal_sensory_capabilities1.14515903
97MP0002909_abnormal_adrenal_gland1.13748192
98MP0000462_abnormal_digestive_system1.12666052
99MP0001968_abnormal_touch/_nociception1.12500962
100MP0001970_abnormal_pain_threshold1.12129406
101MP0005386_behavior/neurological_phenoty1.11763969
102MP0004924_abnormal_behavior1.11763969
103MP0008932_abnormal_embryonic_tissue1.11759940
104MP0010094_abnormal_chromosome_stability1.10629135
105MP0001730_embryonic_growth_arrest1.09405890
106MP0000631_abnormal_neuroendocrine_gland1.09150000
107MP0002210_abnormal_sex_determination1.08501017
108MP0002229_neurodegeneration1.08179910
109MP0002066_abnormal_motor_capabilities/c1.07647670
110MP0002160_abnormal_reproductive_system1.05583824
111MP0003938_abnormal_ear_development1.05149906
112MP0005360_urolithiasis1.04018202
113MP0002896_abnormal_bone_mineralization1.03999265
114MP0000428_abnormal_craniofacial_morphol1.03716393
115MP0003634_abnormal_glial_cell1.03411690
116MP0002557_abnormal_social/conspecific_i1.03124617
117MP0003693_abnormal_embryo_hatching1.03048435
118MP0005551_abnormal_eye_electrophysiolog1.02744351
119MP0002733_abnormal_thermal_nociception1.02120550
120MP0001177_atelectasis1.01885662
121MP0003698_abnormal_male_reproductive1.00458247
122MP0002084_abnormal_developmental_patter1.00358361
123MP0009703_decreased_birth_body1.00156051
124MP0005646_abnormal_pituitary_gland0.99446801
125MP0009379_abnormal_foot_pigmentation0.98814572
126MP0001299_abnormal_eye_distance/0.98757423
127MP0005085_abnormal_gallbladder_physiolo0.98406189
128MP0003077_abnormal_cell_cycle0.98351088
129MP0003115_abnormal_respiratory_system0.98120550
130MP0003566_abnormal_cell_adhesion0.97742650
131MP0001672_abnormal_embryogenesis/_devel0.97026954
132MP0005380_embryogenesis_phenotype0.97026954
133MP0005501_abnormal_skin_physiology0.96958676
134MP0006072_abnormal_retinal_apoptosis0.96614861
135MP0002085_abnormal_embryonic_tissue0.95517251
136MP0000026_abnormal_inner_ear0.95306086
137MP0003329_amyloid_beta_deposits0.94953699
138MP0001929_abnormal_gametogenesis0.94695156
139MP0003119_abnormal_digestive_system0.94440460
140MP0004957_abnormal_blastocyst_morpholog0.93769695
141MP0003984_embryonic_growth_retardation0.93307905
142MP0002088_abnormal_embryonic_growth/wei0.92813705
143MP0000427_abnormal_hair_cycle0.92756411
144MP0003935_abnormal_craniofacial_develop0.89706500
145MP0005187_abnormal_penis_morphology0.89701849
146MP0002822_catalepsy0.89467561
147MP0002233_abnormal_nose_morphology0.89064077
148MP0002736_abnormal_nociception_after0.88609516
149MP0001697_abnormal_embryo_size0.88253962
150MP0005365_abnormal_bile_salt0.88032439
151MP0000377_abnormal_hair_follicle0.87973375
152MP0001145_abnormal_male_reproductive0.87523225
153MP0000467_abnormal_esophagus_morphology0.87469002
154MP0001661_extended_life_span0.87089903
155MP0002060_abnormal_skin_morphology0.87070366
156MP0004811_abnormal_neuron_physiology0.86899601
157MP0000003_abnormal_adipose_tissue0.86780328
158MP0008569_lethality_at_weaning0.86390840
159MP0003755_abnormal_palate_morphology0.86224888
160MP0002086_abnormal_extraembryonic_tissu0.86105977
161MP0008260_abnormal_autophagy0.85402133
162MP0002092_abnormal_eye_morphology0.85167678
163MP0003631_nervous_system_phenotype0.85061516
164MP0000653_abnormal_sex_gland0.84491327
165MP0002089_abnormal_postnatal_growth/wei0.83788630
166MP0004197_abnormal_fetal_growth/weight/0.82763961
167MP0002938_white_spotting0.80991833
168MP0002751_abnormal_autonomic_nervous0.80429235
169MP0003936_abnormal_reproductive_system0.80421212
170MP0000432_abnormal_head_morphology0.79607373
171MP0003385_abnormal_body_wall0.78549755
172MP0002139_abnormal_hepatobiliary_system0.78504877
173MP0002108_abnormal_muscle_morphology0.78480460
174MP0005275_abnormal_skin_tensile0.78284039
175MP0004145_abnormal_muscle_electrophysio0.78229624
176MP0001346_abnormal_lacrimal_gland0.78030386
177MP0002249_abnormal_larynx_morphology0.76942370
178MP0003690_abnormal_glial_cell0.74546676
179MP0005623_abnormal_meninges_morphology0.74510552
180MP0001286_abnormal_eye_development0.74431218
181MP0002080_prenatal_lethality0.73895011

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)4.06824284
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.01875165
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.01875165
4Abnormality of the corticospinal tract (HP:0002492)3.60476217
5Breast hypoplasia (HP:0003187)3.20725668
6Abnormality of the labia minora (HP:0012880)3.14459939
7Myokymia (HP:0002411)2.91034270
8Asymmetry of the thorax (HP:0001555)2.88483559
9Birth length less than 3rd percentile (HP:0003561)2.83743890
10Focal motor seizures (HP:0011153)2.78012851
11CNS hypomyelination (HP:0003429)2.70272954
12Absent septum pellucidum (HP:0001331)2.67319862
13Adrenal hypoplasia (HP:0000835)2.62858414
14Hypoplastic pelvis (HP:0008839)2.62608484
15Abnormality of the septum pellucidum (HP:0007375)2.55274920
16Stomach cancer (HP:0012126)2.52761004
17Peripheral hypomyelination (HP:0007182)2.46789741
18Septo-optic dysplasia (HP:0100842)2.46338690
19Right ventricular cardiomyopathy (HP:0011663)2.40853143
20Termporal pattern (HP:0011008)2.40388551
21Insidious onset (HP:0003587)2.40388551
22Supernumerary spleens (HP:0009799)2.39428032
23Duplicated collecting system (HP:0000081)2.35482368
24Flat acetabular roof (HP:0003180)2.35415923
25Absent radius (HP:0003974)2.34176334
26Aplasia involving forearm bones (HP:0009822)2.33800229
27Absent forearm bone (HP:0003953)2.33800229
28Morphological abnormality of the inner ear (HP:0011390)2.31256863
29Microglossia (HP:0000171)2.30931994
30Ankle clonus (HP:0011448)2.30199438
31Neurofibrillary tangles (HP:0002185)2.29067561
32Abnormal auditory evoked potentials (HP:0006958)2.24952915
33Parakeratosis (HP:0001036)2.24570652
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23995405
35Deep philtrum (HP:0002002)2.19258989
36Papillary thyroid carcinoma (HP:0002895)2.19249156
37Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.19181535
38Spastic gait (HP:0002064)2.19099259
39Limb dystonia (HP:0002451)2.12639231
40Aplasia/Hypoplasia of the breasts (HP:0010311)2.12429221
41Breast aplasia (HP:0100783)2.12001571
42Esophageal atresia (HP:0002032)2.11340488
43Abnormality of monocarboxylic acid metabolism (HP:0010996)2.10053074
44Missing ribs (HP:0000921)2.09174268
45Ankyloglossia (HP:0010296)2.08546966
46Progressive external ophthalmoplegia (HP:0000590)2.07087482
47Increased nuchal translucency (HP:0010880)2.06854825
48Chromsome breakage (HP:0040012)2.06462427
49Broad-based gait (HP:0002136)2.06349682
50Deep venous thrombosis (HP:0002625)2.04833002
51Alacrima (HP:0000522)2.03717401
52Sparse lateral eyebrow (HP:0005338)2.03615172
53Coronal craniosynostosis (HP:0004440)2.03362755
54Split foot (HP:0001839)2.01785288
55Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.00960659
56Septate vagina (HP:0001153)1.99624418
57Abnormality of the distal phalanx of the thumb (HP:0009617)1.98413606
58Curly hair (HP:0002212)1.97231472
59Patellar aplasia (HP:0006443)1.97225528
60Hypobetalipoproteinemia (HP:0003563)1.97046336
61Abnormality of the renal collecting system (HP:0004742)1.96523718
62Carpal bone hypoplasia (HP:0001498)1.94945779
63Stenosis of the external auditory canal (HP:0000402)1.94881269
64Hyperacusis (HP:0010780)1.92575555
65Abnormal ventriculo-arterial connection (HP:0011563)1.92209235
66Transposition of the great arteries (HP:0001669)1.92209235
67Abnormal connection of the cardiac segments (HP:0011545)1.92209235
68Fetal akinesia sequence (HP:0001989)1.91308965
69Decreased lacrimation (HP:0000633)1.91285206
70Dysmetria (HP:0001310)1.91117881
71Advanced eruption of teeth (HP:0006288)1.90259202
72Gait imbalance (HP:0002141)1.90117353
73Gastroesophageal reflux (HP:0002020)1.88232214
74Intrahepatic cholestasis (HP:0001406)1.87615743
75Germ cell neoplasia (HP:0100728)1.87233644
76Leukodystrophy (HP:0002415)1.86949005
77Exostoses (HP:0100777)1.86835992
78Arterial tortuosity (HP:0005116)1.86388073
79Genital tract atresia (HP:0001827)1.85383036
80Vaginal atresia (HP:0000148)1.84540725
81Aplasia involving bones of the extremities (HP:0009825)1.83690271
82Aplasia involving bones of the upper limbs (HP:0009823)1.83690271
83Aplasia of the phalanges of the hand (HP:0009802)1.83690271
84Aplasia/Hypoplasia of the patella (HP:0006498)1.82982020
85Protrusio acetabuli (HP:0003179)1.81427078
86Onion bulb formation (HP:0003383)1.81171451
87Abnormality of the phalanges of the hallux (HP:0010057)1.80522410
88Abnormal lung lobation (HP:0002101)1.79085023
89Enlarged penis (HP:0000040)1.78854862
90Congenital malformation of the right heart (HP:0011723)1.78153068
91Double outlet right ventricle (HP:0001719)1.78153068
92Gastrointestinal atresia (HP:0002589)1.77946021
93Hepatoblastoma (HP:0002884)1.77029401
94Shallow orbits (HP:0000586)1.76270089
95External ophthalmoplegia (HP:0000544)1.75328196
96Overriding aorta (HP:0002623)1.75032085
97Short nail (HP:0001799)1.74404945
98Scanning speech (HP:0002168)1.73996625
99Breast carcinoma (HP:0003002)1.73819955
100Hypoglycemic seizures (HP:0002173)1.73456142
101Abnormality of the clitoris (HP:0000056)1.73354972
102Supranuclear gaze palsy (HP:0000605)1.72376530
103Macroorchidism (HP:0000053)1.71641629
104Abnormal cartilage morphology (HP:0002763)1.70474104
105Aplasia/Hypoplasia involving the musculature (HP:0001460)1.70247083
106Epileptic encephalopathy (HP:0200134)1.70026822
107Focal seizures (HP:0007359)1.68809996
108Mutism (HP:0002300)1.68284168
109Oligodactyly (hands) (HP:0001180)1.67689625
110Cerebral inclusion bodies (HP:0100314)1.67264374
111Bowel incontinence (HP:0002607)1.66809681
112Facial hemangioma (HP:0000329)1.66682767
113Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66661740
114Relative macrocephaly (HP:0004482)1.66023321
115Bifid scrotum (HP:0000048)1.65140489
116Cubitus valgus (HP:0002967)1.64667308
117Vascular tortuosity (HP:0004948)1.64306141
118Delusions (HP:0000746)1.63584313
119Obstructive sleep apnea (HP:0002870)1.63546043
120Myelomeningocele (HP:0002475)1.63259673
121Congenital glaucoma (HP:0001087)1.63182247
122Shawl scrotum (HP:0000049)1.63039553
123Neoplasm of the oral cavity (HP:0100649)1.62736234
124Optic nerve hypoplasia (HP:0000609)1.61653004
125Asplenia (HP:0001746)1.61434770
126Aplasia/Hypoplasia of the earlobes (HP:0009906)1.61102508
127Renovascular hypertension (HP:0100817)1.60784303
128Overlapping toe (HP:0001845)1.60613488
129Congenital primary aphakia (HP:0007707)1.60466562
130Abnormal large intestine physiology (HP:0012700)1.59494334
131Hypopigmentation of the fundus (HP:0007894)1.58233505
132Anteriorly placed anus (HP:0001545)1.57853398
133Premature rupture of membranes (HP:0001788)1.57245976
134Neonatal short-limb short stature (HP:0008921)1.57205744
135Gout (HP:0001997)1.56176960
136Turricephaly (HP:0000262)1.56005482
137Osteolytic defects of the phalanges of the hand (HP:0009771)1.55864303
138Osteolytic defects of the hand bones (HP:0009699)1.55864303
139Heterotopia (HP:0002282)1.54525891
140Abnormality of cochlea (HP:0000375)1.54325916
141Progressive cerebellar ataxia (HP:0002073)1.54033630
142Sleep apnea (HP:0010535)1.53911529
143Aplasia/Hypoplasia of the tibia (HP:0005772)1.53109638
144Medial flaring of the eyebrow (HP:0010747)1.53068416
145Abnormality of carpal bone ossification (HP:0006257)1.52605168
146Duplication of thumb phalanx (HP:0009942)1.52236519
147Abnormality of the distal phalanges of the toes (HP:0010182)1.51822706
148Abnormality of the proximal phalanges of the hand (HP:0009834)1.51751627
149Supernumerary bones of the axial skeleton (HP:0009144)1.51515570
150Abnormality of the gastric mucosa (HP:0004295)1.51427529
151Partial duplication of thumb phalanx (HP:0009944)1.50800324
152Lower limb muscle weakness (HP:0007340)1.50639935
153Intestinal atresia (HP:0011100)1.49330768
154Ectopic kidney (HP:0000086)1.49177300
155Pterygium (HP:0001059)1.47794200
156Vertebral arch anomaly (HP:0008438)1.47742637
157Aplasia/Hypoplasia of the sternum (HP:0006714)1.47436434
158Overgrowth (HP:0001548)1.47316298
159Aplasia/Hypoplasia of the spleen (HP:0010451)1.47312377
160Congenital ichthyosiform erythroderma (HP:0007431)1.47132658
161Spinal cord compression (HP:0002176)1.46635241
162Natal tooth (HP:0000695)1.46632244
163Deviation of the thumb (HP:0009603)1.46526416
164Decreased motor nerve conduction velocity (HP:0003431)1.46332945
165Buphthalmos (HP:0000557)1.46056842
166Thyroid carcinoma (HP:0002890)1.45320052
167Ankle contracture (HP:0006466)1.45010297
168Abnormality of dentin (HP:0010299)1.44386842
169Tracheal stenosis (HP:0002777)1.44272303
170Back pain (HP:0003418)1.44128975
171Partial duplication of the phalanx of hand (HP:0009999)1.43818910
172Biliary tract neoplasm (HP:0100574)1.43707823
173Breech presentation (HP:0001623)1.43356664
174Arnold-Chiari malformation (HP:0002308)1.42151372
175Ulnar bowing (HP:0003031)1.42072110
176Renal duplication (HP:0000075)1.41338848
177Abnormal tarsal ossification (HP:0008369)1.41336062
178Insomnia (HP:0100785)1.41307915
179Abnormality of nail color (HP:0100643)1.41240961
180Abnormality of permanent molar morphology (HP:0011071)1.40987221
181Abnormality of the dental root (HP:0006486)1.40987221
182Taurodontia (HP:0000679)1.40987221
183Facial cleft (HP:0002006)1.39231898
184Vertebral clefting (HP:0008428)1.37732469
185Hyperparathyroidism (HP:0000843)1.36989900
186Astrocytoma (HP:0009592)1.36694562
187Abnormality of the astrocytes (HP:0100707)1.36694562
188Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.36011520
189Symptomatic seizures (HP:0011145)1.35934865
190Broad metatarsal (HP:0001783)1.35546004
191Abnormality of aromatic amino acid family metabolism (HP:0004338)1.35115466
192Abnormality of molar morphology (HP:0011070)1.34517588
193Abnormality of molar (HP:0011077)1.34517588
194Elfin facies (HP:0004428)1.34173353
195Bronchomalacia (HP:0002780)1.33727848
196Wormian bones (HP:0002645)1.32962806

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.12305879
2PNCK3.10077597
3PLK42.88212110
4STK392.87347840
5SCYL22.64273136
6TRIB32.63325550
7EEF2K2.47729181
8PINK12.19303256
9DYRK22.14517483
10BUB12.05607065
11ICK2.05416775
12MST1R2.03798358
13LATS22.03138913
14CASK2.00779701
15RIPK11.91727332
16PDGFRA1.86975620
17PKN21.86611271
18OXSR11.86580125
19RPS6KB21.85939554
20CDK121.84017538
21ZAK1.79323429
22TSSK61.78001055
23EIF2AK11.75403157
24MAP3K41.68937350
25MAPK131.66724392
26SIK11.61003672
27PKN11.56263451
28EPHA21.54971698
29TTK1.51191631
30BCR1.50922145
31PLK31.50728633
32PBK1.50603756
33MAP2K71.50294217
34MAPKAPK51.49730649
35EPHA41.43013855
36NEK61.42615002
37BRSK21.40557258
38SRPK11.37765562
39PTK21.37156299
40CDC71.36352057
41UHMK11.33064767
42MKNK11.31025498
43NTRK31.25162803
44PAK61.25040117
45MAP3K91.24468269
46CAMK1G1.24366688
47CAMK2B1.20184809
48NEK11.19709652
49MTOR1.19218652
50PLK21.18181978
51MKNK21.17834429
52IRAK21.17475804
53WEE11.11912122
54CHEK21.11830961
55STK38L1.11761303
56STK31.09559963
57CDK71.08927658
58SGK2231.05827930
59SGK4941.05827930
60TAF11.04676006
61CSNK1G31.04613059
62LIMK11.02750689
63NTRK20.96653605
64PIK3CA0.94176132
65FGFR20.93893571
66DMPK0.93549108
67MAP3K20.93512683
68FER0.93481221
69CSNK1A1L0.93279442
70MET0.92626959
71CAMK1D0.92342922
72FGFR10.91425916
73BMPR1B0.91393873
74FGFR40.87979434
75PLK10.87075548
76PAK40.85728804
77CSNK1G20.85707687
78AKT30.85595569
79PRKD30.84833789
80WNK10.84183730
81LATS10.82856906
82TNIK0.82621873
83CLK10.82198332
84BMPR20.81964791
85PAK20.79435324
86CAMK2D0.79198233
87PRKCI0.78387738
88PDGFRB0.78007123
89CSNK1G10.77915785
90NTRK10.77796729
91YES10.76779455
92SMG10.76350008
93PRPF4B0.75949964
94CDK30.75718953
95NEK20.74189708
96ERBB40.73231985
97AURKA0.73187791
98ERBB30.73011233
99MAP2K10.71890091
100CDK60.71862523
101BRSK10.71649149
102RPS6KB10.71385732
103TYRO30.70268906
104VRK10.69684448
105MAP3K120.69143034
106AURKB0.68927771
107CDK50.68879273
108CDK150.68867602
109ROCK20.68647153
110CAMK2A0.68610902
111MAP3K60.68200785
112MARK20.67374955
113KSR20.66966068
114RET0.66435667
115CDK180.65528862
116CHEK10.64946314
117WNK40.64867521
118FGR0.64592008
119CDK140.64471328
120MUSK0.64463552
121CAMK2G0.64048313
122MAP3K100.63897714
123IRAK30.63834704
124CDK11A0.63253182
125CSNK1E0.62738237
126CDK190.62118774
127KSR10.61429859
128DYRK1A0.60703764
129MINK10.58650139
130MAPKAPK30.58066295
131BRD40.57668449
132MELK0.57639694
133BRAF0.57499907
134EIF2AK30.55591169
135CSNK1D0.54059933
136TESK20.53423691
137AKT20.53400211
138PTK60.52209471
139CDK10.51762273
140MAP2K20.50596495
141SGK30.50226449
142PHKG20.50024146
143PHKG10.50024146
144ARAF0.48470435
145STK160.48239488
146MAPK100.47429383
147ALK0.47228987
148ATM0.47084066
149RPS6KA50.46232922
150ILK0.44609625
151LMTK20.44056072
152CDK20.41797655
153GSK3A0.41093621
154ATR0.40074491
155EIF2AK20.38818992
156MAPK140.38024133
157RPS6KA20.37858378

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.21194959
2RNA polymerase_Homo sapiens_hsa030202.94275571
3Nicotine addiction_Homo sapiens_hsa050332.40166940
4Ether lipid metabolism_Homo sapiens_hsa005652.18075032
5Basal transcription factors_Homo sapiens_hsa030222.17145272
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14750891
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11733122
8Steroid biosynthesis_Homo sapiens_hsa001001.99430405
9Vitamin B6 metabolism_Homo sapiens_hsa007501.97314412
10Glutamatergic synapse_Homo sapiens_hsa047241.80864244
11Arginine biosynthesis_Homo sapiens_hsa002201.75413658
12Fanconi anemia pathway_Homo sapiens_hsa034601.74820991
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.68463798
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.67856931
15GABAergic synapse_Homo sapiens_hsa047271.62476552
16Mismatch repair_Homo sapiens_hsa034301.61373032
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59063913
18Spliceosome_Homo sapiens_hsa030401.58818761
19RNA transport_Homo sapiens_hsa030131.55991238
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55528617
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55175231
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54865094
23Synaptic vesicle cycle_Homo sapiens_hsa047211.53638658
24Axon guidance_Homo sapiens_hsa043601.51203854
25Caffeine metabolism_Homo sapiens_hsa002321.50847423
26Serotonergic synapse_Homo sapiens_hsa047261.50546924
27DNA replication_Homo sapiens_hsa030301.50053868
28Homologous recombination_Homo sapiens_hsa034401.48539254
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.45641182
30RNA degradation_Homo sapiens_hsa030181.44853381
31Morphine addiction_Homo sapiens_hsa050321.42185165
32Cell cycle_Homo sapiens_hsa041101.41845028
33Linoleic acid metabolism_Homo sapiens_hsa005911.34077814
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.33204938
35Oocyte meiosis_Homo sapiens_hsa041141.31996564
36Histidine metabolism_Homo sapiens_hsa003401.30978186
37Circadian entrainment_Homo sapiens_hsa047131.30645340
38Biosynthesis of amino acids_Homo sapiens_hsa012301.28870816
39Lysine degradation_Homo sapiens_hsa003101.28733611
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28706492
41mRNA surveillance pathway_Homo sapiens_hsa030151.28695085
42Long-term depression_Homo sapiens_hsa047301.28667890
43Pyruvate metabolism_Homo sapiens_hsa006201.27410101
44Thyroid cancer_Homo sapiens_hsa052161.26072478
45Phototransduction_Homo sapiens_hsa047441.24918041
46Proteasome_Homo sapiens_hsa030501.24584542
47Nucleotide excision repair_Homo sapiens_hsa034201.23795454
48Arginine and proline metabolism_Homo sapiens_hsa003301.21772553
49Non-homologous end-joining_Homo sapiens_hsa034501.21378188
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17423420
51Bile secretion_Homo sapiens_hsa049761.16452093
52Dopaminergic synapse_Homo sapiens_hsa047281.14761334
53Amphetamine addiction_Homo sapiens_hsa050311.14429528
54Adherens junction_Homo sapiens_hsa045201.13722906
55Taste transduction_Homo sapiens_hsa047421.12092575
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10558527
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10319632
58Phenylalanine metabolism_Homo sapiens_hsa003601.09110477
59Long-term potentiation_Homo sapiens_hsa047201.08772380
60Hedgehog signaling pathway_Homo sapiens_hsa043401.08615784
61Oxidative phosphorylation_Homo sapiens_hsa001901.08093001
62Central carbon metabolism in cancer_Homo sapiens_hsa052301.07692868
63Pyrimidine metabolism_Homo sapiens_hsa002401.06959008
64Huntingtons disease_Homo sapiens_hsa050161.06220577
65Purine metabolism_Homo sapiens_hsa002301.04139245
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03739329
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03652962
68Steroid hormone biosynthesis_Homo sapiens_hsa001401.02677378
69Propanoate metabolism_Homo sapiens_hsa006401.02276026
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01326331
71Cysteine and methionine metabolism_Homo sapiens_hsa002701.01126885
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.99298749
73Sphingolipid metabolism_Homo sapiens_hsa006000.99209060
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98896239
75Carbon metabolism_Homo sapiens_hsa012000.98434865
76Tight junction_Homo sapiens_hsa045300.98033418
77One carbon pool by folate_Homo sapiens_hsa006700.97959417
78Olfactory transduction_Homo sapiens_hsa047400.96527262
79Fatty acid biosynthesis_Homo sapiens_hsa000610.96424350
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96151454
81Fatty acid elongation_Homo sapiens_hsa000620.95901367
82Cocaine addiction_Homo sapiens_hsa050300.95864883
83Fatty acid degradation_Homo sapiens_hsa000710.94532113
84Hippo signaling pathway_Homo sapiens_hsa043900.94350584
85Cholinergic synapse_Homo sapiens_hsa047250.93936788
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93885341
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93636588
88Retinol metabolism_Homo sapiens_hsa008300.93449467
89Protein export_Homo sapiens_hsa030600.93332705
90Parkinsons disease_Homo sapiens_hsa050120.92558087
91Fatty acid metabolism_Homo sapiens_hsa012120.92468769
92Collecting duct acid secretion_Homo sapiens_hsa049660.92335160
93AMPK signaling pathway_Homo sapiens_hsa041520.91399313
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91162048
95Endometrial cancer_Homo sapiens_hsa052130.91090169
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87750116
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87172836
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87154705
99Wnt signaling pathway_Homo sapiens_hsa043100.86352204
100Tyrosine metabolism_Homo sapiens_hsa003500.85248776
101beta-Alanine metabolism_Homo sapiens_hsa004100.84322332
102Alcoholism_Homo sapiens_hsa050340.83943306
103Renal cell carcinoma_Homo sapiens_hsa052110.83251527
104Fat digestion and absorption_Homo sapiens_hsa049750.83190476
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83174329
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.82976833
107Salivary secretion_Homo sapiens_hsa049700.81395015
108Starch and sucrose metabolism_Homo sapiens_hsa005000.80771357
109Gap junction_Homo sapiens_hsa045400.80445765
110ECM-receptor interaction_Homo sapiens_hsa045120.79528452
111Prion diseases_Homo sapiens_hsa050200.79229719
112Ras signaling pathway_Homo sapiens_hsa040140.78893698
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78220021
114Prostate cancer_Homo sapiens_hsa052150.78188721
115Basal cell carcinoma_Homo sapiens_hsa052170.77511230
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77368634
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76529341
118Complement and coagulation cascades_Homo sapiens_hsa046100.75090673
119Vitamin digestion and absorption_Homo sapiens_hsa049770.74878386
120Thyroid hormone synthesis_Homo sapiens_hsa049180.74639039
121ErbB signaling pathway_Homo sapiens_hsa040120.74253179
122Pentose phosphate pathway_Homo sapiens_hsa000300.74039264
123GnRH signaling pathway_Homo sapiens_hsa049120.73515476
124Chemical carcinogenesis_Homo sapiens_hsa052040.73370683
125Selenocompound metabolism_Homo sapiens_hsa004500.73112051
126Dorso-ventral axis formation_Homo sapiens_hsa043200.72835204
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72145366
128MicroRNAs in cancer_Homo sapiens_hsa052060.71812573
129Insulin signaling pathway_Homo sapiens_hsa049100.71316181
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71208683
131Base excision repair_Homo sapiens_hsa034100.70099124
132Ovarian steroidogenesis_Homo sapiens_hsa049130.68839592
133Glucagon signaling pathway_Homo sapiens_hsa049220.67952188
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67431526
135Vibrio cholerae infection_Homo sapiens_hsa051100.67197432
136Melanogenesis_Homo sapiens_hsa049160.66823719
137Alzheimers disease_Homo sapiens_hsa050100.66628162
138Arachidonic acid metabolism_Homo sapiens_hsa005900.66153149
139Insulin secretion_Homo sapiens_hsa049110.65400229
140Chronic myeloid leukemia_Homo sapiens_hsa052200.64600393
141Estrogen signaling pathway_Homo sapiens_hsa049150.64597965
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64269600
143TGF-beta signaling pathway_Homo sapiens_hsa043500.64130975
144Choline metabolism in cancer_Homo sapiens_hsa052310.63782063
145Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62879505
146Galactose metabolism_Homo sapiens_hsa000520.62493991
147Fructose and mannose metabolism_Homo sapiens_hsa000510.62050683
148Primary bile acid biosynthesis_Homo sapiens_hsa001200.61647086
149Gastric acid secretion_Homo sapiens_hsa049710.61354467
150Proteoglycans in cancer_Homo sapiens_hsa052050.61241467
151Sulfur metabolism_Homo sapiens_hsa009200.60584944
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.60573758
153Melanoma_Homo sapiens_hsa052180.60280840
154Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59696693
155Glioma_Homo sapiens_hsa052140.58961535
156Focal adhesion_Homo sapiens_hsa045100.58907209
157N-Glycan biosynthesis_Homo sapiens_hsa005100.58482098
158Tryptophan metabolism_Homo sapiens_hsa003800.57981407
159Folate biosynthesis_Homo sapiens_hsa007900.57937468
160Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57778955
161Protein digestion and absorption_Homo sapiens_hsa049740.57562866
162Renin-angiotensin system_Homo sapiens_hsa046140.57058942
163Phospholipase D signaling pathway_Homo sapiens_hsa040720.55717786
164Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55582621
165Bladder cancer_Homo sapiens_hsa052190.55357313
166PPAR signaling pathway_Homo sapiens_hsa033200.55161421
167Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55052952
168Oxytocin signaling pathway_Homo sapiens_hsa049210.54969675
169Cardiac muscle contraction_Homo sapiens_hsa042600.53575002
170MAPK signaling pathway_Homo sapiens_hsa040100.53327880
171Sphingolipid signaling pathway_Homo sapiens_hsa040710.53079714
172Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52297182
173Vascular smooth muscle contraction_Homo sapiens_hsa042700.51256113
174Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50549706
175Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49628370
176Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47578510
177Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46933594
178Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46572778
179cAMP signaling pathway_Homo sapiens_hsa040240.46317401
180Calcium signaling pathway_Homo sapiens_hsa040200.45098057
181Renin secretion_Homo sapiens_hsa049240.43826964

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