KCTD18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)9.41645936
2daunorubicin metabolic process (GO:0044597)9.41645936
3polyketide metabolic process (GO:0030638)9.41645936
4maintenance of protein location in nucleus (GO:0051457)5.97227134
5aminoglycoside antibiotic metabolic process (GO:0030647)5.73388396
6negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.65697042
7regulation of nuclear cell cycle DNA replication (GO:0033262)5.55248650
8histone H4-K5 acetylation (GO:0043981)5.54755549
9histone H4-K8 acetylation (GO:0043982)5.54755549
10regulation of response to osmotic stress (GO:0047484)5.49550851
11negative regulation of epidermis development (GO:0045683)5.33352358
12regulation of MHC class I biosynthetic process (GO:0045343)5.24470697
13negative regulation of cell cycle G2/M phase transition (GO:1902750)5.22420904
14protein localization to kinetochore (GO:0034501)5.19935471
15regulation of telomere maintenance via telomerase (GO:0032210)5.12465273
16somite rostral/caudal axis specification (GO:0032525)5.11444209
17regulation of mammary gland epithelial cell proliferation (GO:0033599)5.04553154
18histone H4-K12 acetylation (GO:0043983)4.90959839
19rRNA transcription (GO:0009303)4.79306510
20muscle organ morphogenesis (GO:0048644)4.62006435
21negative regulation of telomerase activity (GO:0051974)4.53573145
22histone H4-K16 acetylation (GO:0043984)4.51583742
23interferon-gamma production (GO:0032609)4.45985179
24regulation of cilium movement (GO:0003352)4.42914035
25nuclear pore complex assembly (GO:0051292)4.22337870
26negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.21137794
27negative regulation of telomere maintenance (GO:0032205)4.14605913
28chromatin assembly (GO:0031497)4.03223227
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.01843310
30negative regulation of epidermal cell differentiation (GO:0045605)4.01473443
31mitotic sister chromatid segregation (GO:0000070)4.00888454
32regulation of telomere maintenance (GO:0032204)4.00389505
33protein localization to chromosome, centromeric region (GO:0071459)3.96105806
34cytidine catabolic process (GO:0006216)3.91432307
35cytidine deamination (GO:0009972)3.91432307
36cytidine metabolic process (GO:0046087)3.91432307
37positive regulation of DNA-dependent DNA replication (GO:2000105)3.90823151
38rRNA methylation (GO:0031167)3.89443365
39phenol-containing compound catabolic process (GO:0019336)3.84424219
40response to dietary excess (GO:0002021)3.81350627
41heterochromatin organization (GO:0070828)3.80209767
42cell fate commitment involved in formation of primary germ layer (GO:0060795)3.77579779
43behavioral response to nicotine (GO:0035095)3.77162859
44interkinetic nuclear migration (GO:0022027)3.71397873
45quinone metabolic process (GO:1901661)3.67233087
46DNA replication-dependent nucleosome organization (GO:0034723)3.65804481
47DNA replication-dependent nucleosome assembly (GO:0006335)3.65804481
48nuclear pore organization (GO:0006999)3.65286290
49cilium or flagellum-dependent cell motility (GO:0001539)3.60209306
50protein polyglutamylation (GO:0018095)3.56971369
51branching involved in mammary gland duct morphogenesis (GO:0060444)3.55944754
52neural tube formation (GO:0001841)3.54322338
53DNA replication checkpoint (GO:0000076)3.50035007
54sister chromatid segregation (GO:0000819)3.50029411
55regulation of B cell receptor signaling pathway (GO:0050855)3.44278316
56microtubule severing (GO:0051013)3.42286792
57pre-miRNA processing (GO:0031054)3.40285634
58mitotic chromosome condensation (GO:0007076)3.39742398
59epithelial cilium movement (GO:0003351)3.39599016
60rRNA modification (GO:0000154)3.34302993
61regulation of memory T cell differentiation (GO:0043380)3.32791245
62nucleoside transmembrane transport (GO:1901642)3.32065284
63intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.31911429
64response to pheromone (GO:0019236)3.31715528
65protein K11-linked deubiquitination (GO:0035871)3.31231028
66regulation of translation in response to stress (GO:0043555)3.29206020
67positive regulation of gamma-delta T cell activation (GO:0046645)3.28303770
68indole-containing compound catabolic process (GO:0042436)3.27676708
69indolalkylamine catabolic process (GO:0046218)3.27676708
70tryptophan catabolic process (GO:0006569)3.27676708
71notochord development (GO:0030903)3.22219012
72fucose catabolic process (GO:0019317)3.21305757
73L-fucose metabolic process (GO:0042354)3.21305757
74L-fucose catabolic process (GO:0042355)3.21305757
75primitive streak formation (GO:0090009)3.20909310
76indolalkylamine metabolic process (GO:0006586)3.20649940
77pore complex assembly (GO:0046931)3.19129568
78DNA deamination (GO:0045006)3.18916474
79histone H3-K4 methylation (GO:0051568)3.14639128
80mitochondrion distribution (GO:0048311)3.13641488
81ventricular system development (GO:0021591)3.13635551
82axoneme assembly (GO:0035082)3.12232524
83DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.10761939
84tachykinin receptor signaling pathway (GO:0007217)3.10332001
85bone trabecula formation (GO:0060346)3.08449266
86detection of light stimulus involved in sensory perception (GO:0050962)3.03035565
87detection of light stimulus involved in visual perception (GO:0050908)3.03035565
88regulation of telomerase activity (GO:0051972)3.00933592
89DNA damage response, detection of DNA damage (GO:0042769)3.00190675
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.99888100
91cilium movement (GO:0003341)2.98694342
92activated T cell proliferation (GO:0050798)2.95819305
93regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95184376
94negative regulation of interleukin-2 production (GO:0032703)2.89071400
95axon ensheathment in central nervous system (GO:0032291)2.84553134
96central nervous system myelination (GO:0022010)2.84553134
97intestinal epithelial cell development (GO:0060576)2.84452734
98regulation of microtubule-based movement (GO:0060632)2.84119620
99regulation of regulatory T cell differentiation (GO:0045589)2.83588225
100negative regulation of mast cell activation (GO:0033004)2.83322545
101positive regulation of defense response to virus by host (GO:0002230)2.82231328
102positive regulation of protein deacetylation (GO:0090312)2.82064828
103detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.81378489
104cullin deneddylation (GO:0010388)2.81303183
105preassembly of GPI anchor in ER membrane (GO:0016254)2.81282868
106spindle assembly (GO:0051225)2.80469553
107regulation of apoptotic process involved in morphogenesis (GO:1902337)2.79446569
108coenzyme catabolic process (GO:0009109)2.78695652
109phosphatidylinositol 3-kinase signaling (GO:0014065)2.78616445
110tryptophan metabolic process (GO:0006568)2.78021219
111regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.77616825
112negative regulation of viral release from host cell (GO:1902187)2.77022310
113negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.76524368
114regulation of double-strand break repair (GO:2000779)2.76394275
115histone H3-K4 trimethylation (GO:0080182)2.72536627
116positive regulation of developmental pigmentation (GO:0048087)2.72429469
117maintenance of protein localization in organelle (GO:0072595)2.71614869
118cardiovascular system development (GO:0072358)2.70922014
119establishment of protein localization to Golgi (GO:0072600)2.70022724
120amine catabolic process (GO:0009310)2.69281122
121cellular biogenic amine catabolic process (GO:0042402)2.69281122
122DNA damage response, signal transduction resulting in transcription (GO:0042772)2.69197520
123arachidonic acid secretion (GO:0050482)2.68849215
124icosanoid secretion (GO:0032309)2.68849215
125positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.66479093
126regulation of gamma-delta T cell differentiation (GO:0045586)2.66314552
127regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.66265279
128detection of temperature stimulus (GO:0016048)2.65231889
129DNA duplex unwinding (GO:0032508)2.64426278
130regulation of gamma-delta T cell activation (GO:0046643)2.64306631
131RNA stabilization (GO:0043489)2.63959613
132mRNA stabilization (GO:0048255)2.63959613
133DNA geometric change (GO:0032392)2.61519762
134mitotic G2/M transition checkpoint (GO:0044818)2.61057654
135purinergic nucleotide receptor signaling pathway (GO:0035590)2.60746095
136positive regulation of tolerance induction (GO:0002645)2.59662311
137platelet dense granule organization (GO:0060155)2.58234731
138anterior/posterior axis specification (GO:0009948)2.57758487
139sulfation (GO:0051923)2.56489095
140cellular extravasation (GO:0045123)2.55287225
141cellular response to ethanol (GO:0071361)2.53571936
142regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.52770925
143positive regulation of granulocyte differentiation (GO:0030854)2.52332384
144hormone catabolic process (GO:0042447)2.51329980
145positive regulation of B cell differentiation (GO:0045579)2.50982892
146positive regulation of T cell mediated cytotoxicity (GO:0001916)2.49920371
147cellular ketone body metabolic process (GO:0046950)2.48605080
148organelle membrane fusion (GO:0090174)2.48254630
149pyrimidine ribonucleoside catabolic process (GO:0046133)2.47490514
150autophagic vacuole fusion (GO:0000046)2.45980120
151phosphatidylinositol acyl-chain remodeling (GO:0036149)2.43529937
152piRNA metabolic process (GO:0034587)2.43224991
153negative regulation of T cell mediated immunity (GO:0002710)2.43036384
154drug catabolic process (GO:0042737)2.42951147
155negative T cell selection (GO:0043383)2.42889494
156protein localization to cilium (GO:0061512)2.42516321
157photoreceptor cell maintenance (GO:0045494)2.37088731
158rhodopsin mediated signaling pathway (GO:0016056)2.36865732
159kynurenine metabolic process (GO:0070189)2.34377574
160regulation of T cell mediated cytotoxicity (GO:0001914)2.32914366
161negative thymic T cell selection (GO:0045060)2.32798862
162exogenous drug catabolic process (GO:0042738)2.31529794
163regulation of rhodopsin mediated signaling pathway (GO:0022400)2.30599558
164regulation of B cell differentiation (GO:0045577)2.29296698
165B cell receptor signaling pathway (GO:0050853)2.28896033
166I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.24471809
167mast cell activation (GO:0045576)2.23270828
168negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.22293597
169ketone body metabolic process (GO:1902224)2.20381360
170regulation of action potential (GO:0098900)2.20328867
171negative regulation of cAMP-mediated signaling (GO:0043951)2.19931590
172regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.19799633
173microglial cell activation (GO:0001774)2.19137016
174negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.19031131
175cellular response to interleukin-15 (GO:0071350)2.18043575
176indole-containing compound metabolic process (GO:0042430)2.17652691
177protein K63-linked deubiquitination (GO:0070536)2.17144123
178centriole replication (GO:0007099)2.15600575
179positive regulation of T-helper 1 type immune response (GO:0002827)2.15578308
180protein targeting to Golgi (GO:0000042)2.15436922
181regulation of MHC class II biosynthetic process (GO:0045346)2.14188130
182regulation of germinal center formation (GO:0002634)2.14075440
183regulation of T cell receptor signaling pathway (GO:0050856)2.13913455
184DNA methylation involved in gamete generation (GO:0043046)2.13568891
185regulation of alpha-beta T cell proliferation (GO:0046640)2.12950049
186negative regulation of calcium ion transport into cytosol (GO:0010523)2.12930877
187reflex (GO:0060004)2.12627751
188superoxide anion generation (GO:0042554)2.11783873
189cilium morphogenesis (GO:0060271)2.10666642
190cilium organization (GO:0044782)2.10320601
191cell wall macromolecule metabolic process (GO:0044036)2.10064949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.97787123
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.97787123
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.97787123
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.62063643
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.69565645
6E2F7_22180533_ChIP-Seq_HELA_Human4.39238881
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.75171636
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.44331627
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.10146268
10ZNF274_21170338_ChIP-Seq_K562_Hela2.95180215
11SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.86973462
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85075276
13TCF3_18692474_ChIP-Seq_MESCs_Mouse2.71367727
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.60020391
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.56698351
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.47048015
17GBX2_23144817_ChIP-Seq_PC3_Human2.46263858
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.32646295
19VDR_22108803_ChIP-Seq_LS180_Human2.32009723
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.30492705
21NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.24620024
22EZH2_22144423_ChIP-Seq_EOC_Human2.19771839
23TCF3_18692474_ChIP-Seq_MEFs_Mouse2.18262865
24* FLI1_27457419_Chip-Seq_LIVER_Mouse2.13860087
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11730870
26ER_23166858_ChIP-Seq_MCF-7_Human2.07789095
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06875298
28NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.06791031
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.06761839
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.05351215
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01138167
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.95274903
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92722221
34IRF1_19129219_ChIP-ChIP_H3396_Human1.92438100
35TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.86220483
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85409887
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79621696
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77498596
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.77141794
40* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74185943
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73853407
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71518687
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69026016
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.68790792
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.65929023
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64956408
47RUNX_20019798_ChIP-Seq_JUKART_Human1.64265192
48TAF15_26573619_Chip-Seq_HEK293_Human1.64035242
49EWS_26573619_Chip-Seq_HEK293_Human1.63221428
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61930813
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59158484
52P300_19829295_ChIP-Seq_ESCs_Human1.58524059
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.57630058
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55296477
55NANOG_18692474_ChIP-Seq_MESCs_Mouse1.51449148
56* STAT3_23295773_ChIP-Seq_U87_Human1.50076109
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49547140
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.49235468
59POU5F1_16518401_ChIP-PET_MESCs_Mouse1.49098837
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46988482
61BCAT_22108803_ChIP-Seq_LS180_Human1.44611088
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42234210
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42210539
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42078993
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42072685
66FUS_26573619_Chip-Seq_HEK293_Human1.41750557
67ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.40874934
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39940327
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38932149
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.38806960
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38572405
72MYC_22102868_ChIP-Seq_BL_Human1.38560750
73E2F1_17053090_ChIP-ChIP_MCF-7_Human1.37825110
74SMAD4_21799915_ChIP-Seq_A2780_Human1.37167073
75* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36826917
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36805270
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35995410
78TCF4_23295773_ChIP-Seq_U87_Human1.35896339
79GATA3_26560356_Chip-Seq_TH2_Human1.35447344
80* EZH2_27294783_Chip-Seq_NPCs_Mouse1.35069794
81TP53_16413492_ChIP-PET_HCT116_Human1.33660717
82TBX3_20139965_ChIP-Seq_ESCs_Mouse1.33333513
83TBX3_20139965_ChIP-Seq_MESCs_Mouse1.33029844
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.31976530
85AR_25329375_ChIP-Seq_VCAP_Human1.31762456
86* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31185102
87* NFE2_27457419_Chip-Seq_LIVER_Mouse1.30845693
88PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.29203833
89* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28521851
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28266346
91SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27627910
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.26366518
93* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.26182100
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26133841
95CBP_20019798_ChIP-Seq_JUKART_Human1.26133841
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25465696
97RNF2_27304074_Chip-Seq_NSC_Mouse1.25449654
98NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25001522
99SOX2_18692474_ChIP-Seq_MESCs_Mouse1.24653078
100* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24611170
101EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24396716
102* CRX_20693478_ChIP-Seq_RETINA_Mouse1.23194299
103SCL_19346495_ChIP-Seq_HPC-7_Human1.23190448
104NANOG_18692474_ChIP-Seq_MEFs_Mouse1.21468506
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20028746
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19009473
107* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.18997373
108MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17972133
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.17718325
110SOX2_19829295_ChIP-Seq_ESCs_Human1.17349653
111NANOG_19829295_ChIP-Seq_ESCs_Human1.17349653
112VDR_24787735_ChIP-Seq_THP-1_Human1.16151414
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15177533
114SMRT_27268052_Chip-Seq_Bcells_Human1.13435457
115FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12472585
116* TP53_22573176_ChIP-Seq_HFKS_Human1.12327018
117HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11803095
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11649977
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11649977
120MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11240103
121* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11062347
122FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11004493
123FOXA1_25329375_ChIP-Seq_VCAP_Human1.11004493
124IGF1R_20145208_ChIP-Seq_DFB_Human1.10729912
125ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10709011
126TCF4_22108803_ChIP-Seq_LS180_Human1.10131026
127* NANOG_18555785_Chip-Seq_ESCs_Mouse1.10052074
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09521464
129NANOG_16153702_ChIP-ChIP_HESCs_Human1.09368490
130* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08355962
131AR_21572438_ChIP-Seq_LNCaP_Human1.08278851
132* P53_22387025_ChIP-Seq_ESCs_Mouse1.07602225
133RUNX2_22187159_ChIP-Seq_PCA_Human1.07571471
134* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06765768
135* CDX2_22108803_ChIP-Seq_LS180_Human1.06110057
136TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05574256
137* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04832234
138TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04721181
139* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04224664
140YY1_21170310_ChIP-Seq_MESCs_Mouse1.04024563
141GATA3_21878914_ChIP-Seq_MCF-7_Human1.03996667
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03583554
143IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03088732
144SMAD4_21741376_ChIP-Seq_EPCs_Human1.02441047
145SOX2_16153702_ChIP-ChIP_HESCs_Human1.02152895
146* SMAD3_21741376_ChIP-Seq_EPCs_Human1.01635209
147NANOG_21062744_ChIP-ChIP_HESCs_Human1.00837404
148GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99806162
149BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99763485
150NANOG_16518401_ChIP-PET_MESCs_Mouse0.99673918
151PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99335031
152DROSHA_22980978_ChIP-Seq_HELA_Human0.99108441
153VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98956081
154STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98928582
155AR_20517297_ChIP-Seq_VCAP_Human0.98630880
156* TP53_22127205_ChIP-Seq_IMR90_Human0.98596153
157GATA3_27048872_Chip-Seq_THYMUS_Human0.98457404
158TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98130775
159ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97956586
160CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97637151
161WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95980166
162STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95370079
163TCF7_22412390_ChIP-Seq_EML_Mouse0.94332824
164FOXO3_23340844_ChIP-Seq_DLD1_Human0.93686592
165CIITA_25753668_ChIP-Seq_RAJI_Human0.92938017
166ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92703519
167STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92643585
168STAT3_18555785_ChIP-Seq_MESCs_Mouse0.90512542
169SALL1_21062744_ChIP-ChIP_HESCs_Human0.89905095
170MYC_18555785_ChIP-Seq_MESCs_Mouse0.89848263
171NCOR1_26117541_ChIP-Seq_K562_Human0.89186255
172FOXP3_21729870_ChIP-Seq_TREG_Human0.88557403
173NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88228860
174E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87460300
175CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87031103
176KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86211351
177KDM5A_27292631_Chip-Seq_BREAST_Human0.85607480
178GATA1_22025678_ChIP-Seq_K562_Human0.85250825
179KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85136755
180GATA1_26923725_Chip-Seq_HPCs_Mouse0.84897654
181FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84320000
182KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.83599739
183SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78844681
184EOMES_21245162_ChIP-Seq_HESCs_Human0.76636675
185EST1_17652178_ChIP-ChIP_JURKAT_Human0.76377148
186ELK4_26923725_Chip-Seq_MESODERM_Mouse0.75093247
187KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.73484253
188* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.73302806
189CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.71713536
190GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.71546246
191KDM2B_26808549_Chip-Seq_SUP-B15_Human0.71167234
192MYCN_18555785_ChIP-Seq_MESCs_Mouse0.70123957

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.01172564
2MP0008057_abnormal_DNA_replication4.00061827
3MP0005075_abnormal_melanosome_morpholog3.54965687
4MP0003890_abnormal_embryonic-extraembry3.49257752
5MP0004264_abnormal_extraembryonic_tissu3.16610641
6MP0003011_delayed_dark_adaptation2.99254034
7MP0005499_abnormal_olfactory_system2.83361231
8MP0005394_taste/olfaction_phenotype2.83361231
9MP0002254_reproductive_system_inflammat2.72336169
10MP0003122_maternal_imprinting2.58498764
11MP0004957_abnormal_blastocyst_morpholog2.54429933
12MP0003195_calcinosis2.44140468
13MP0003121_genomic_imprinting2.43205349
14MP0003183_abnormal_peptide_metabolism2.38120334
15MP0005257_abnormal_intraocular_pressure2.31124481
16MP0005671_abnormal_response_to2.17749128
17MP0003938_abnormal_ear_development2.17471813
18MP0001835_abnormal_antigen_presentation2.15125677
19MP0005174_abnormal_tail_pigmentation2.14738898
20MP0002876_abnormal_thyroid_physiology2.13798348
21MP0003724_increased_susceptibility_to2.05692488
22MP0006035_abnormal_mitochondrial_morpho2.05504237
23MP0001800_abnormal_humoral_immune1.98103651
24MP0004858_abnormal_nervous_system1.97454462
25MP0003646_muscle_fatigue1.96166749
26MP0004381_abnormal_hair_follicle1.92872999
27MP0002653_abnormal_ependyma_morphology1.92605639
28MP0001293_anophthalmia1.92330335
29MP0000685_abnormal_immune_system1.92158125
30MP0002138_abnormal_hepatobiliary_system1.90565652
31MP0003252_abnormal_bile_duct1.89641288
32MP0001501_abnormal_sleep_pattern1.82858201
33MP0005551_abnormal_eye_electrophysiolog1.82079347
34MP0005464_abnormal_platelet_physiology1.80119513
35MP0001790_abnormal_immune_system1.79100635
36MP0005387_immune_system_phenotype1.79100635
37MP0002332_abnormal_exercise_endurance1.76616359
38MP0005645_abnormal_hypothalamus_physiol1.72213083
39MP0010386_abnormal_urinary_bladder1.71161361
40MP0005380_embryogenesis_phenotype1.70698561
41MP0001672_abnormal_embryogenesis/_devel1.70698561
42MP0005084_abnormal_gallbladder_morpholo1.68320538
43MP0008872_abnormal_physiological_respon1.65607592
44MP0002092_abnormal_eye_morphology1.62534163
45MP0002148_abnormal_hypersensitivity_rea1.62281164
46MP0002088_abnormal_embryonic_growth/wei1.60675555
47MP0003984_embryonic_growth_retardation1.59656619
48MP0000427_abnormal_hair_cycle1.59466097
49MP0010352_gastrointestinal_tract_polyps1.57051888
50MP0008877_abnormal_DNA_methylation1.55596904
51MP0002928_abnormal_bile_duct1.55091684
52MP0002723_abnormal_immune_serum1.54474520
53MP0009764_decreased_sensitivity_to1.53077112
54MP0000350_abnormal_cell_proliferation1.52755222
55MP0003763_abnormal_thymus_physiology1.48005326
56MP0002277_abnormal_respiratory_mucosa1.47921757
57MP0005083_abnormal_biliary_tract1.47910637
58MP0002452_abnormal_antigen_presenting1.46991107
59MP0002396_abnormal_hematopoietic_system1.46458293
60MP0003077_abnormal_cell_cycle1.45161107
61MP0000015_abnormal_ear_pigmentation1.44922490
62MP0008961_abnormal_basal_metabolism1.44550604
63MP0002837_dystrophic_cardiac_calcinosis1.40787221
64MP0005000_abnormal_immune_tolerance1.40486437
65MP0010094_abnormal_chromosome_stability1.39588003
66MP0000383_abnormal_hair_follicle1.38698968
67MP0002102_abnormal_ear_morphology1.38506028
68MP0003787_abnormal_imprinting1.37234714
69MP0009785_altered_susceptibility_to1.36691181
70MP0003045_fibrosis1.35561443
71MP0002420_abnormal_adaptive_immunity1.34816980
72MP0002233_abnormal_nose_morphology1.34782547
73MP0002085_abnormal_embryonic_tissue1.34434054
74MP0005085_abnormal_gallbladder_physiolo1.33808316
75MP0010030_abnormal_orbit_morphology1.32805907
76MP0002114_abnormal_axial_skeleton1.32503344
77MP0003111_abnormal_nucleus_morphology1.32182820
78MP0005365_abnormal_bile_salt1.31127655
79MP0001819_abnormal_immune_cell1.31121453
80MP0002932_abnormal_joint_morphology1.30129759
81MP0002084_abnormal_developmental_patter1.28267175
82MP0000230_abnormal_systemic_arterial1.25945581
83MP0002095_abnormal_skin_pigmentation1.22647079
84MP0004130_abnormal_muscle_cell1.21574665
85MP0000428_abnormal_craniofacial_morphol1.21467214
86MP0005646_abnormal_pituitary_gland1.20701970
87MP0001873_stomach_inflammation1.19992150
88MP0000762_abnormal_tongue_morphology1.19479644
89MP0002419_abnormal_innate_immunity1.18780104
90MP0008007_abnormal_cellular_replicative1.18726458
91MP0005025_abnormal_response_to1.18093374
92MP0002405_respiratory_system_inflammati1.17790236
93MP0006054_spinal_hemorrhage1.17694480
94MP0008875_abnormal_xenobiotic_pharmacok1.16935786
95MP0001986_abnormal_taste_sensitivity1.16812205
96MP0000432_abnormal_head_morphology1.16389313
97MP0002086_abnormal_extraembryonic_tissu1.15947117
98MP0009703_decreased_birth_body1.15679948
99MP0003755_abnormal_palate_morphology1.15569154
100MP0008932_abnormal_embryonic_tissue1.14462894
101MP0000678_abnormal_parathyroid_gland1.13754733
102MP0005167_abnormal_blood-brain_barrier1.12527576
103MP0006082_CNS_inflammation1.12509059
104MP0001348_abnormal_lacrimal_gland1.12265432
105MP0002638_abnormal_pupillary_reflex1.12223478
106MP0005253_abnormal_eye_physiology1.12109140
107MP0003123_paternal_imprinting1.12008599
108MP0002132_abnormal_respiratory_system1.10328345
109MP0000372_irregular_coat_pigmentation1.08547168
110MP0000049_abnormal_middle_ear1.08340889
111MP0002751_abnormal_autonomic_nervous1.08024802
112MP0003937_abnormal_limbs/digits/tail_de1.07415921
113MP0002970_abnormal_white_adipose1.07070471
114MP0003935_abnormal_craniofacial_develop1.06626679
115MP0008789_abnormal_olfactory_epithelium1.06528126
116MP0005391_vision/eye_phenotype1.06524959
117MP0001849_ear_inflammation1.05912620
118MP0004043_abnormal_pH_regulation1.04177694
119MP0005623_abnormal_meninges_morphology1.03264884
120MP0000778_abnormal_nervous_system1.02993009
121MP0001968_abnormal_touch/_nociception1.02944098
122MP0008058_abnormal_DNA_repair1.02429010
123MP0002693_abnormal_pancreas_physiology1.00783924
124MP0003693_abnormal_embryo_hatching1.00058803
125MP0004142_abnormal_muscle_tone0.99905898
126MP0000920_abnormal_myelination0.99854855
127MP0002909_abnormal_adrenal_gland0.99828235
128MP0000716_abnormal_immune_system0.96031913
129MP0004185_abnormal_adipocyte_glucose0.95762509
130MP0001845_abnormal_inflammatory_respons0.95364288
131MP0000371_diluted_coat_color0.95083641
132MP0008770_decreased_survivor_rate0.94353854
133MP0005389_reproductive_system_phenotype0.93633308
134MP0003861_abnormal_nervous_system0.92787411
135MP0010678_abnormal_skin_adnexa0.91994903
136MP0001919_abnormal_reproductive_system0.91420565
137MP0004197_abnormal_fetal_growth/weight/0.91286740
138MP0010329_abnormal_lipoprotein_level0.90866012
139MP0000689_abnormal_spleen_morphology0.90751969
140MP0000313_abnormal_cell_death0.90242244
141MP0009046_muscle_twitch0.89896966
142MP0008775_abnormal_heart_ventricle0.89634475
143MP0001730_embryonic_growth_arrest0.88925955
144MP0003172_abnormal_lysosome_physiology0.88888258
145MP0004133_heterotaxia0.88727726
146MP0001697_abnormal_embryo_size0.88708707
147MP0002398_abnormal_bone_marrow0.88421845
148MP0006072_abnormal_retinal_apoptosis0.87758177
149MP0009745_abnormal_behavioral_response0.86724544
150MP0002127_abnormal_cardiovascular_syste0.86232700
151MP0000647_abnormal_sebaceous_gland0.85530172
152MP0002168_other_aberrant_phenotype0.85115990
153MP0000465_gastrointestinal_hemorrhage0.84922664
154MP0004885_abnormal_endolymph0.84538188
155MP0003436_decreased_susceptibility_to0.83845125
156MP0003786_premature_aging0.83602328
157MP0004147_increased_porphyrin_level0.83066944
158MP0001486_abnormal_startle_reflex0.82130635
159MP0002163_abnormal_gland_morphology0.81951889
160MP0002116_abnormal_craniofacial_bone0.81571246
161MP0005508_abnormal_skeleton_morphology0.80861955
162MP0001764_abnormal_homeostasis0.80794632
163MP0002166_altered_tumor_susceptibility0.80335121
164MP0001145_abnormal_male_reproductive0.80097114
165MP0003950_abnormal_plasma_membrane0.79357041
166MP0005310_abnormal_salivary_gland0.79356678
167MP0003315_abnormal_perineum_morphology0.78927100
168MP0001286_abnormal_eye_development0.78620883
169MP0002081_perinatal_lethality0.77775894
170MP0005379_endocrine/exocrine_gland_phen0.76636647
171MP0003866_abnormal_defecation0.74599585
172MP0001663_abnormal_digestive_system0.74238558
173MP0005410_abnormal_fertilization0.74119879
174MP0002080_prenatal_lethality0.73753635
175MP0001984_abnormal_olfaction0.72858490
176MP0004484_altered_response_of0.71460845
177MP0001765_abnormal_ion_homeostasis0.71237428
178MP0002272_abnormal_nervous_system0.71100980
179MP0002925_abnormal_cardiovascular_devel0.68024097
180MP0001929_abnormal_gametogenesis0.67576593
181MP0000569_abnormal_digit_pigmentation0.67258976
182MP0002210_abnormal_sex_determination0.66798927
183MP0000955_abnormal_spinal_cord0.66548497
184MP0005384_cellular_phenotype0.65453799
185MP0000490_abnormal_crypts_of0.65111714
186MP0002752_abnormal_somatic_nervous0.63874655
187MP0000377_abnormal_hair_follicle0.63157368

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.94518985
2Hypochromic microcytic anemia (HP:0004840)5.04905128
3Rib fusion (HP:0000902)4.43716528
4Pancreatic cysts (HP:0001737)4.41658416
5Ependymoma (HP:0002888)4.22992990
6Hepatoblastoma (HP:0002884)4.09992468
7Sensory axonal neuropathy (HP:0003390)3.98748516
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.96317678
9Pancreatic fibrosis (HP:0100732)3.79940336
10Congenital stationary night blindness (HP:0007642)3.76680760
11Type II lissencephaly (HP:0007260)3.73326813
12Abnormality of the renal cortex (HP:0011035)3.65267843
13Stomatitis (HP:0010280)3.62774341
14Nephroblastoma (Wilms tumor) (HP:0002667)3.61699120
15True hermaphroditism (HP:0010459)3.56144842
16Chromsome breakage (HP:0040012)3.54832515
17Abnormality of the lower motor neuron (HP:0002366)3.51765084
18Neoplasm of striated muscle (HP:0009728)3.48357427
19Nephronophthisis (HP:0000090)3.48218782
20Multiple enchondromatosis (HP:0005701)3.41162559
21Hypoplasia of the fovea (HP:0007750)3.39135731
22Aplasia/Hypoplasia of the fovea (HP:0008060)3.39135731
23Abnormality of the renal medulla (HP:0100957)3.36581020
24Embryonal renal neoplasm (HP:0011794)3.31256459
25Anomalous pulmonary venous return (HP:0010772)3.17143194
26Abnormality of the salivary glands (HP:0010286)3.16784320
27Bifid tongue (HP:0010297)3.13143251
28Abnormality of the astrocytes (HP:0100707)3.12961994
29Astrocytoma (HP:0009592)3.12961994
30Rectal fistula (HP:0100590)3.11975056
31Rectovaginal fistula (HP:0000143)3.11975056
32Partial duplication of thumb phalanx (HP:0009944)3.10354388
33Attenuation of retinal blood vessels (HP:0007843)3.09063918
34Absent/shortened dynein arms (HP:0200106)3.08380118
35Dynein arm defect of respiratory motile cilia (HP:0012255)3.08380118
36Rhabdomyosarcoma (HP:0002859)3.03278380
37Intestinal fistula (HP:0100819)3.03250310
38Tubular atrophy (HP:0000092)2.92160415
39Abnormal drinking behavior (HP:0030082)2.89324641
40Polydipsia (HP:0001959)2.89324641
41Thyroiditis (HP:0100646)2.88792524
42Abolished electroretinogram (ERG) (HP:0000550)2.86976300
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.86788981
44Abnormal rod and cone electroretinograms (HP:0008323)2.80946243
45Abnormal respiratory motile cilium morphology (HP:0005938)2.78616943
46Abnormal respiratory epithelium morphology (HP:0012253)2.78616943
47Chronic hepatic failure (HP:0100626)2.78452065
48Panhypogammaglobulinemia (HP:0003139)2.77232680
49Fused cervical vertebrae (HP:0002949)2.74118985
50Decreased central vision (HP:0007663)2.71753857
51Large earlobe (HP:0009748)2.71131202
52Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.71114504
53Increased corneal curvature (HP:0100692)2.70714810
54Keratoconus (HP:0000563)2.70714810
55Partial duplication of the phalanx of hand (HP:0009999)2.70112137
56Abnormality of the pulmonary veins (HP:0011718)2.68196234
57Abnormality of chromosome segregation (HP:0002916)2.67537380
58Cystic liver disease (HP:0006706)2.66884393
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.66686247
60Genetic anticipation (HP:0003743)2.63530611
61Vaginal fistula (HP:0004320)2.62207664
62Elevated erythrocyte sedimentation rate (HP:0003565)2.62002311
63Cerebellar dysplasia (HP:0007033)2.60093896
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.59978900
65Neoplasm of the heart (HP:0100544)2.56180500
66Medial flaring of the eyebrow (HP:0010747)2.53958836
67Abnormality of the fovea (HP:0000493)2.53257836
68Abnormal delayed hypersensitivity skin test (HP:0002963)2.52048680
69Hyperinsulinemic hypoglycemia (HP:0000825)2.51986210
70Abnormality of B cell number (HP:0010975)2.50925830
71Abnormal ciliary motility (HP:0012262)2.50580697
72Amyotrophic lateral sclerosis (HP:0007354)2.48445124
73Generalized hypotonia (HP:0001290)2.48416384
74Congenital hepatic fibrosis (HP:0002612)2.47830174
75Abnormality of the ileum (HP:0001549)2.47045500
76Optic neuritis (HP:0100653)2.45714619
77Retrobulbar optic neuritis (HP:0100654)2.45714619
78Meckel diverticulum (HP:0002245)2.45082339
79Abnormal lung lobation (HP:0002101)2.44919101
80Abnormality of the phalanges of the hallux (HP:0010057)2.43879055
81Nasolacrimal duct obstruction (HP:0000579)2.42483362
82Abnormality of T cell number (HP:0011839)2.39348109
83Progressive inability to walk (HP:0002505)2.35806261
84Myositis (HP:0100614)2.34768116
85Tetraplegia (HP:0002445)2.33644266
86Recurrent cutaneous fungal infections (HP:0011370)2.32657659
87Chronic mucocutaneous candidiasis (HP:0002728)2.32657659
88Renal cortical cysts (HP:0000803)2.31025205
89Aplasia/hypoplasia of the humerus (HP:0006507)2.30935669
90Inability to walk (HP:0002540)2.30517431
91Hyperventilation (HP:0002883)2.30312366
92Testicular atrophy (HP:0000029)2.29623273
93Widely spaced teeth (HP:0000687)2.29488440
94Recurrent fungal infections (HP:0002841)2.28936655
95Glioma (HP:0009733)2.28640658
96Gaze-evoked nystagmus (HP:0000640)2.27066165
97Neoplasm of the oral cavity (HP:0100649)2.26906714
98Preauricular pit (HP:0004467)2.25921058
99Periauricular skin pits (HP:0100277)2.25921058
100Hypopigmentation of the fundus (HP:0007894)2.25883813
101Short humerus (HP:0005792)2.25258492
102Decreased circulating renin level (HP:0003351)2.24005175
103Aplasia/Hypoplasia of the macula (HP:0008059)2.22796112
104Fair hair (HP:0002286)2.22138328
105Abnormality of the distal phalanx of the thumb (HP:0009617)2.21098399
106Polyuria (HP:0000103)2.20917545
107Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.20209088
108Congenital sensorineural hearing impairment (HP:0008527)2.19973475
109Abnormality of the pons (HP:0007361)2.18532527
110T lymphocytopenia (HP:0005403)2.18250449
111Clumsiness (HP:0002312)2.18198387
112Concave nail (HP:0001598)2.17339836
113Hypoproteinemia (HP:0003075)2.17240572
114Abnormal respiratory motile cilium physiology (HP:0012261)2.17169966
115Duplication of thumb phalanx (HP:0009942)2.16293042
116Broad alveolar ridges (HP:0000187)2.15833986
117Volvulus (HP:0002580)2.14027089
118Severe combined immunodeficiency (HP:0004430)2.12374599
119Febrile seizures (HP:0002373)2.12187797
120Preauricular skin tag (HP:0000384)2.11784321
121Eosinophilia (HP:0001880)2.11559110
122Abnormality of eosinophils (HP:0001879)2.10955051
123Horizontal nystagmus (HP:0000666)2.10641725
124Abnormal auditory evoked potentials (HP:0006958)2.09273227
125Medulloblastoma (HP:0002885)2.08742993
126Abnormality of the musculature of the hand (HP:0001421)2.08236814
127Microvesicular hepatic steatosis (HP:0001414)2.07789367
128Shawl scrotum (HP:0000049)2.07692555
129Orchitis (HP:0100796)2.06604077
130Ragged-red muscle fibers (HP:0003200)2.06412589
131Tubulointerstitial fibrosis (HP:0005576)2.06206973
132Aplasia/Hypoplasia affecting the retina (HP:0008061)2.05981740
133Abnormality of small intestinal villus morphology (HP:0011472)2.04546640
134Villous atrophy (HP:0011473)2.04546640
135Difficulty running (HP:0009046)2.03703353
136Hypoplasia of the pons (HP:0012110)2.03138362
137Bile duct proliferation (HP:0001408)2.01412908
138Abnormal biliary tract physiology (HP:0012439)2.01412908
139Progressive cerebellar ataxia (HP:0002073)2.00832505
140Impulsivity (HP:0100710)2.00745129
141IgG deficiency (HP:0004315)2.00724128
142Supernumerary spleens (HP:0009799)2.00354626
143Abnormality of the corticospinal tract (HP:0002492)2.00268366
144Stomach cancer (HP:0012126)2.00254474
145Large for gestational age (HP:0001520)1.99989899
146Lissencephaly (HP:0001339)1.98291223
147Tented upper lip vermilion (HP:0010804)1.98288802
148B lymphocytopenia (HP:0010976)1.97596879
149Prominent occiput (HP:0000269)1.97014096
150Supernumerary ribs (HP:0005815)1.96998117
151Encephalitis (HP:0002383)1.96979601
152Chronic sinusitis (HP:0011109)1.96805706
153Pancreatic islet-cell hyperplasia (HP:0004510)1.96300642
154Skin tags (HP:0010609)1.96237658
155Furrowed tongue (HP:0000221)1.95181619
156Facial cleft (HP:0002006)1.94660376
157Hypothermia (HP:0002045)1.93136152
158Tubulointerstitial abnormality (HP:0001969)1.92955375
159Open mouth (HP:0000194)1.91312741
160Dislocated radial head (HP:0003083)1.91233181
161Progressive muscle weakness (HP:0003323)1.90552239
162Abnormality of midbrain morphology (HP:0002418)1.90467406
163Molar tooth sign on MRI (HP:0002419)1.90467406
164Prolonged bleeding time (HP:0003010)1.90260372
165Aplasia/Hypoplasia of the spleen (HP:0010451)1.90008169
166Increased neuronal autofluorescent lipopigment (HP:0002074)1.89965067
167Reduced antithrombin III activity (HP:0001976)1.89491434
168Pulmonary infiltrates (HP:0002113)1.88795362
169Chronic otitis media (HP:0000389)1.88479295
170Embryonal neoplasm (HP:0002898)1.88234711
171Focal motor seizures (HP:0011153)1.87338366
172Retinal dysplasia (HP:0007973)1.86036301
173Skin pits (HP:0100276)1.85448310
174Autoimmune hemolytic anemia (HP:0001890)1.85275452
175Abnormality of the lacrimal duct (HP:0011481)1.85210651
176Trismus (HP:0000211)1.85159832
177Abnormality of the labia minora (HP:0012880)1.84384132
178Congenital primary aphakia (HP:0007707)1.84242212
179Protruding tongue (HP:0010808)1.84212051
180Nephrogenic diabetes insipidus (HP:0009806)1.83656080
181Aplasia/Hypoplasia of the tongue (HP:0010295)1.83563017
1823-Methylglutaconic aciduria (HP:0003535)1.82846291
183Keratoconjunctivitis (HP:0001096)1.82082490
184Dialeptic seizures (HP:0011146)1.80878595
185Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80366526
186Absence seizures (HP:0002121)1.79844230
187Abnormality of T cells (HP:0002843)1.79700753
188Leukocytosis (HP:0001974)1.79578797
189Small intestinal stenosis (HP:0012848)1.79353219
190Duodenal stenosis (HP:0100867)1.79353219
191Premature ovarian failure (HP:0008209)1.78703552
192Gait imbalance (HP:0002141)1.78677287
193Abnormality of the radial head (HP:0003995)1.78230654
194Vertebral fusion (HP:0002948)1.78136410
195Hemivertebrae (HP:0002937)1.77290981

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.88064705
2FRK6.08238184
3GRK54.73852995
4TAOK34.15400233
5GRK64.02952280
6GRK12.96488149
7CSF1R2.85787879
8ADRBK22.82146223
9TXK2.72819228
10ERN12.72153083
11TYRO32.64470712
12WNK42.38107229
13WNK12.37316577
14MAP4K22.34812984
15CAMKK22.26645862
16BMPR1B2.22745797
17PINK12.21080780
18TTK2.12410654
19MAPK72.06834919
20STK102.06461114
21TGFBR22.05056907
22ACVR1B2.01463885
23GRK71.84984631
24NUAK11.84642880
25MATK1.81755381
26TEC1.78311959
27MAP4K11.70184698
28CDK71.58679733
29PIK3CG1.57321267
30NTRK11.57280774
31MARK21.56580478
32MOS1.56301546
33TNK21.48892592
34BRD41.47764513
35IKBKB1.47630449
36MAPK131.39204099
37CHEK21.36245837
38CAMK41.33001401
39SYK1.31300759
40WNK31.27815103
41MAPKAPK31.26619394
42FGFR31.25251527
43BTK1.21955381
44FES1.19012814
45IRAK11.16342953
46IKBKE1.15220540
47TRPM71.13562337
48STK38L1.12414214
49ZAK1.12294460
50PRKCQ1.11306898
51PTK2B1.10109951
52NLK1.09810519
53HIPK21.09765357
54BLK1.09662724
55JAK31.00259496
56DAPK20.99547750
57PIK3CA0.97255329
58CHEK10.96413780
59RIPK40.94412567
60CSK0.93891627
61NEK20.93428420
62INSRR0.92532442
63TGFBR10.92274743
64PLK10.91675182
65ITK0.91105900
66MAP2K40.89915229
67ADRBK10.87826238
68LYN0.85724846
69DYRK20.84273779
70EPHA20.82023396
71PRKG20.81943000
72CAMKK10.81729421
73CHUK0.81031947
74MAP3K140.79077241
75PAK30.78694429
76MARK30.77531778
77TLK10.76504892
78MAPK150.76216632
79CCNB10.75308703
80SRPK10.75203370
81ALK0.74146938
82CDC70.72635172
83MAP3K40.72063568
84MAP2K60.71534220
85DYRK30.68454702
86AKT30.68108858
87BCKDK0.67660687
88JAK10.67141384
89TYK20.67110007
90PRKCE0.66403811
91EPHB10.66306263
92OXSR10.66007069
93IRAK40.65915266
94MAPK100.64739924
95PKN10.64427405
96NTRK20.63859017
97CAMK10.62843918
98FGFR20.62473300
99BUB10.62389069
100BMPR20.60819040
101EIF2AK20.60055318
102MTOR0.59873386
103PRKAA20.59145292
104ATM0.58636183
105CAMK1D0.58256383
106CDK20.58144049
107MAP3K70.55767313
108ZAP700.55666143
109STK110.53434312
110TBK10.52674531
111STK30.51206385
112SGK20.50096780
113CASK0.49707372
114CDK80.49352660
115PAK40.48595134
116CAMK1G0.48538621
117DYRK1A0.48520321
118MST40.48041113
119PRKD20.47570873
120YES10.47360974
121CDK10.47097684
122MET0.47082463
123CSNK1A1L0.46807820
124KIT0.46761076
125PDGFRA0.46031808
126PASK0.43998150
127MAP3K20.43453731
128ERBB30.43273240
129OBSCN0.43010882
130AKT20.41822247
131STK390.41699254
132MAPK110.40322092
133IGF1R0.39917079
134LATS20.39517798
135MAPK120.39405324
136PDGFRB0.39335302
137MAP3K100.39217090
138CSNK1E0.38234299
139GSK3B0.37965985
140PRPF4B0.37353058
141TNIK0.37265136
142MAPK10.36816609
143SIK20.36608738
144JAK20.36603789
145CDK40.36587202
146CSNK1G30.36377115
147ATR0.35399039
148PNCK0.34237539
149INSR0.33689434
150MAP3K30.33507651
151EPHA30.33472180
152PRKACA0.32828768
153MAPK140.32401327
154RPS6KA60.31190020
155CSNK1D0.30549236
156CSNK1G10.30431638
157PIM10.30100406
158PRKCH0.29714444
159LATS10.29357421
160ICK0.29277828
161ABL10.29051872
162AURKA0.27729678
163UHMK10.27605166
164ERBB20.26834438
165MELK0.25795007
166PAK60.25601489
167CSNK1G20.24650680
168HCK0.23996491
169WEE10.23611703
170LCK0.22836452
171GSK3A0.22004571
172MAP3K90.21729830
173AURKB0.20852979

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.09283697
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.61166829
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.48472943
4Phototransduction_Homo sapiens_hsa047442.49142305
5Graft-versus-host disease_Homo sapiens_hsa053322.17944193
6Fanconi anemia pathway_Homo sapiens_hsa034602.14579798
7Allograft rejection_Homo sapiens_hsa053302.03257060
8Nitrogen metabolism_Homo sapiens_hsa009102.01709320
9Autoimmune thyroid disease_Homo sapiens_hsa053201.96426442
10Butanoate metabolism_Homo sapiens_hsa006501.86381774
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78499465
12mRNA surveillance pathway_Homo sapiens_hsa030151.77895053
13Arachidonic acid metabolism_Homo sapiens_hsa005901.75634196
14Type I diabetes mellitus_Homo sapiens_hsa049401.72299198
15ABC transporters_Homo sapiens_hsa020101.69479034
16Fructose and mannose metabolism_Homo sapiens_hsa000511.68129019
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65118676
18RNA transport_Homo sapiens_hsa030131.62288116
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61201945
20Tryptophan metabolism_Homo sapiens_hsa003801.60625675
21Linoleic acid metabolism_Homo sapiens_hsa005911.60074265
22Asthma_Homo sapiens_hsa053101.56776796
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54003349
24Hematopoietic cell lineage_Homo sapiens_hsa046401.50382847
25Non-homologous end-joining_Homo sapiens_hsa034501.46878989
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46782230
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46620538
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44524862
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.42947012
30Caffeine metabolism_Homo sapiens_hsa002321.42640886
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39544620
32Homologous recombination_Homo sapiens_hsa034401.38756629
33Ether lipid metabolism_Homo sapiens_hsa005651.38618448
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.37640570
35Phospholipase D signaling pathway_Homo sapiens_hsa040721.34912849
36Cell cycle_Homo sapiens_hsa041101.34623482
37mTOR signaling pathway_Homo sapiens_hsa041501.33417941
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.30137083
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29375752
40Basal transcription factors_Homo sapiens_hsa030221.29081184
41Olfactory transduction_Homo sapiens_hsa047401.27970800
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26253073
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26101984
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23714307
45Choline metabolism in cancer_Homo sapiens_hsa052311.23486056
46Inositol phosphate metabolism_Homo sapiens_hsa005621.23453784
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20554586
48MicroRNAs in cancer_Homo sapiens_hsa052061.19918402
49RNA polymerase_Homo sapiens_hsa030201.18208618
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17143161
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14749396
52Peroxisome_Homo sapiens_hsa041461.14193957
53Staphylococcus aureus infection_Homo sapiens_hsa051501.13898615
54Primary immunodeficiency_Homo sapiens_hsa053401.13457279
55Selenocompound metabolism_Homo sapiens_hsa004501.12505605
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12042762
57Spliceosome_Homo sapiens_hsa030401.11041928
58Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11037046
59T cell receptor signaling pathway_Homo sapiens_hsa046601.09307501
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09261108
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06074304
62Platelet activation_Homo sapiens_hsa046111.05082084
63Hedgehog signaling pathway_Homo sapiens_hsa043401.03575317
64Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03224396
65Thyroid cancer_Homo sapiens_hsa052161.03181356
66Chemical carcinogenesis_Homo sapiens_hsa052041.02945320
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02561085
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02470791
69Ovarian steroidogenesis_Homo sapiens_hsa049131.02050607
70RNA degradation_Homo sapiens_hsa030181.01705623
71Basal cell carcinoma_Homo sapiens_hsa052171.01068381
72Pathways in cancer_Homo sapiens_hsa052000.96564343
73Propanoate metabolism_Homo sapiens_hsa006400.95954023
74Acute myeloid leukemia_Homo sapiens_hsa052210.94289377
75Antigen processing and presentation_Homo sapiens_hsa046120.94242665
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92386770
77p53 signaling pathway_Homo sapiens_hsa041150.92327162
78Notch signaling pathway_Homo sapiens_hsa043300.91388686
79Leishmaniasis_Homo sapiens_hsa051400.90834923
80Base excision repair_Homo sapiens_hsa034100.90728212
81Taste transduction_Homo sapiens_hsa047420.90672780
82Non-small cell lung cancer_Homo sapiens_hsa052230.89625820
83Glycerolipid metabolism_Homo sapiens_hsa005610.89523633
84Dorso-ventral axis formation_Homo sapiens_hsa043200.88577108
85Colorectal cancer_Homo sapiens_hsa052100.88531162
86Circadian rhythm_Homo sapiens_hsa047100.86963215
87Retinol metabolism_Homo sapiens_hsa008300.86358607
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86297839
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86257494
90Rheumatoid arthritis_Homo sapiens_hsa053230.85831161
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85616842
92Mismatch repair_Homo sapiens_hsa034300.85339444
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84779844
94Rap1 signaling pathway_Homo sapiens_hsa040150.84687476
95Wnt signaling pathway_Homo sapiens_hsa043100.84422713
96Axon guidance_Homo sapiens_hsa043600.83956018
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83865817
98Regulation of autophagy_Homo sapiens_hsa041400.82836920
99Ras signaling pathway_Homo sapiens_hsa040140.81219314
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81119115
101Osteoclast differentiation_Homo sapiens_hsa043800.80661341
102Pancreatic cancer_Homo sapiens_hsa052120.80197129
103Renal cell carcinoma_Homo sapiens_hsa052110.80157449
104B cell receptor signaling pathway_Homo sapiens_hsa046620.79871545
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79283691
106Measles_Homo sapiens_hsa051620.77903405
107ErbB signaling pathway_Homo sapiens_hsa040120.77752965
108Herpes simplex infection_Homo sapiens_hsa051680.77577241
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76454124
110Serotonergic synapse_Homo sapiens_hsa047260.75957742
111DNA replication_Homo sapiens_hsa030300.75166989
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75091051
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.71255266
114beta-Alanine metabolism_Homo sapiens_hsa004100.71169019
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69864596
116Calcium signaling pathway_Homo sapiens_hsa040200.66958928
117Tuberculosis_Homo sapiens_hsa051520.66571067
118Morphine addiction_Homo sapiens_hsa050320.64568010
119Salivary secretion_Homo sapiens_hsa049700.63772570
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.63572452
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.63458871
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.62308520
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61261486
124Long-term depression_Homo sapiens_hsa047300.61212795
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57685303
126Glutamatergic synapse_Homo sapiens_hsa047240.57646856
127Nicotine addiction_Homo sapiens_hsa050330.56928006
128Hippo signaling pathway_Homo sapiens_hsa043900.56521048
129TNF signaling pathway_Homo sapiens_hsa046680.56036515
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55146871
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.54837426
132VEGF signaling pathway_Homo sapiens_hsa043700.54580071
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.54123358
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.53313371
135Galactose metabolism_Homo sapiens_hsa000520.52260494
136Lysosome_Homo sapiens_hsa041420.51859956
137MAPK signaling pathway_Homo sapiens_hsa040100.51798778
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49591301
139Chemokine signaling pathway_Homo sapiens_hsa040620.49131206
140Circadian entrainment_Homo sapiens_hsa047130.48542358
141Viral carcinogenesis_Homo sapiens_hsa052030.48158628
142Endocytosis_Homo sapiens_hsa041440.46607962
143Prostate cancer_Homo sapiens_hsa052150.45268919
144African trypanosomiasis_Homo sapiens_hsa051430.45077710
145Fatty acid degradation_Homo sapiens_hsa000710.45069313
146Sphingolipid metabolism_Homo sapiens_hsa006000.45015278
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.44106831
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44055339
149Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43583202
150Nucleotide excision repair_Homo sapiens_hsa034200.42190398
151Fatty acid biosynthesis_Homo sapiens_hsa000610.41123721
152cAMP signaling pathway_Homo sapiens_hsa040240.41072026
153Histidine metabolism_Homo sapiens_hsa003400.41068534
154Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40792676
155Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40783522
156GABAergic synapse_Homo sapiens_hsa047270.40465357
157Toxoplasmosis_Homo sapiens_hsa051450.40428755
158Lysine degradation_Homo sapiens_hsa003100.40254547
159Malaria_Homo sapiens_hsa051440.39987277
160Proteoglycans in cancer_Homo sapiens_hsa052050.39978176
161AMPK signaling pathway_Homo sapiens_hsa041520.38699230
162Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38537671
163Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38088615
164FoxO signaling pathway_Homo sapiens_hsa040680.37898224
165Intestinal immune network for IgA production_Homo sapiens_hsa046720.36693534
166HTLV-I infection_Homo sapiens_hsa051660.36514750
167Endometrial cancer_Homo sapiens_hsa052130.36244395
168Small cell lung cancer_Homo sapiens_hsa052220.36054465
169Oxytocin signaling pathway_Homo sapiens_hsa049210.35834215
170Type II diabetes mellitus_Homo sapiens_hsa049300.33127383

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