KCP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)6.38422403
2daunorubicin metabolic process (GO:0044597)6.38422403
3polyketide metabolic process (GO:0030638)6.38422403
4cell proliferation involved in metanephros development (GO:0072203)5.11592172
5platelet dense granule organization (GO:0060155)4.90807087
6aminoglycoside antibiotic metabolic process (GO:0030647)4.71088607
7bone trabecula formation (GO:0060346)4.46996037
8lateral sprouting from an epithelium (GO:0060601)4.45317524
9paraxial mesoderm development (GO:0048339)4.39905460
10cell proliferation involved in kidney development (GO:0072111)4.38765033
11gonadal mesoderm development (GO:0007506)4.31156593
12DNA deamination (GO:0045006)4.16020665
13regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.14633289
14regulation of non-canonical Wnt signaling pathway (GO:2000050)4.13362377
15tryptophan catabolic process (GO:0006569)4.03324904
16indole-containing compound catabolic process (GO:0042436)4.03324904
17indolalkylamine catabolic process (GO:0046218)4.03324904
18midgut development (GO:0007494)4.02648247
19planar cell polarity pathway involved in neural tube closure (GO:0090179)4.02487838
20mesenchyme morphogenesis (GO:0072132)3.84483349
21behavioral response to nicotine (GO:0035095)3.84428138
22regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.80444583
23sequestering of extracellular ligand from receptor (GO:0035581)3.80394385
24regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.77910598
25indolalkylamine metabolic process (GO:0006586)3.77854295
26detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.70412964
27outflow tract septum morphogenesis (GO:0003148)3.68509455
28mesenchymal cell proliferation (GO:0010463)3.60829358
29positive regulation of prostaglandin secretion (GO:0032308)3.59367702
30NAD biosynthetic process (GO:0009435)3.56547891
31L-fucose catabolic process (GO:0042355)3.55969533
32fucose catabolic process (GO:0019317)3.55969533
33L-fucose metabolic process (GO:0042354)3.55969533
34neuron projection extension involved in neuron projection guidance (GO:1902284)3.52576130
35axon extension involved in axon guidance (GO:0048846)3.52576130
36lymph vessel development (GO:0001945)3.51363756
37mesenchymal cell differentiation involved in renal system development (GO:2001012)3.50408328
38mesenchymal cell differentiation involved in kidney development (GO:0072161)3.50408328
39gamma-aminobutyric acid transport (GO:0015812)3.50323863
40metanephric mesenchyme development (GO:0072075)3.49907593
41anatomical structure regression (GO:0060033)3.49527395
42kynurenine metabolic process (GO:0070189)3.46842082
43tryptophan metabolic process (GO:0006568)3.46706851
44protein complex biogenesis (GO:0070271)3.42782784
45negative regulation of axon extension involved in axon guidance (GO:0048843)3.37292110
46proximal/distal pattern formation (GO:0009954)3.37065043
47extracellular negative regulation of signal transduction (GO:1900116)3.36622920
48extracellular regulation of signal transduction (GO:1900115)3.36622920
49ganglion development (GO:0061548)3.34690523
50negative regulation of stem cell proliferation (GO:2000647)3.34421699
51cellular biogenic amine catabolic process (GO:0042402)3.33660074
52amine catabolic process (GO:0009310)3.33660074
53craniofacial suture morphogenesis (GO:0097094)3.33500014
54cell migration involved in heart development (GO:0060973)3.32081596
55head development (GO:0060322)3.29991635
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.29870422
57negative regulation of mast cell activation (GO:0033004)3.27498750
58endocardial cushion morphogenesis (GO:0003203)3.23777101
59neural crest cell development (GO:0014032)3.20758456
60kidney mesenchyme development (GO:0072074)3.19957265
61preassembly of GPI anchor in ER membrane (GO:0016254)3.18382681
62respiratory chain complex IV assembly (GO:0008535)3.16961489
63cytochrome complex assembly (GO:0017004)3.13339247
64mitochondrial respiratory chain complex assembly (GO:0033108)3.12084571
65mesenchymal-epithelial cell signaling (GO:0060638)3.10153299
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.09761751
67mitochondrial respiratory chain complex I assembly (GO:0032981)3.09761751
68NADH dehydrogenase complex assembly (GO:0010257)3.09761751
69atrial septum morphogenesis (GO:0060413)3.09634040
70convergent extension (GO:0060026)3.09030955
71protein-cofactor linkage (GO:0018065)3.08040001
72cochlea morphogenesis (GO:0090103)3.07288582
73nephron tubule morphogenesis (GO:0072078)3.06967691
74nephron epithelium morphogenesis (GO:0072088)3.06967691
75protein heterotrimerization (GO:0070208)3.06899770
76detection of molecule of bacterial origin (GO:0032490)3.05293803
77mast cell activation involved in immune response (GO:0002279)3.05179993
78mast cell degranulation (GO:0043303)3.05179993
79hindlimb morphogenesis (GO:0035137)3.05107159
80N-acetylglucosamine metabolic process (GO:0006044)3.02399380
81mesenchymal cell differentiation (GO:0048762)3.01233803
82epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.00888956
83renal tubule morphogenesis (GO:0061333)3.00615759
84proteasome assembly (GO:0043248)3.00033812
85kidney morphogenesis (GO:0060993)2.99182758
86embryonic limb morphogenesis (GO:0030326)2.99148608
87embryonic appendage morphogenesis (GO:0035113)2.99148608
88embryonic skeletal joint morphogenesis (GO:0060272)2.97962659
89mannosylation (GO:0097502)2.96774819
90negative regulation of axon guidance (GO:1902668)2.96428499
91basement membrane organization (GO:0071711)2.95786503
92negative regulation of telomere maintenance (GO:0032205)2.95602401
93response to pheromone (GO:0019236)2.94350039
94mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.93379633
95mast cell activation (GO:0045576)2.92857605
96negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.92747012
97cardiac myofibril assembly (GO:0055003)2.92024153
98positive regulation of hormone biosynthetic process (GO:0046886)2.91665846
99mesenchymal cell development (GO:0014031)2.91437519
100establishment of planar polarity (GO:0001736)2.90450038
101establishment of tissue polarity (GO:0007164)2.90450038
102mesonephros development (GO:0001823)2.88479718
103glomerulus development (GO:0032835)2.87248960
104regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.86988318
105energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.85661238
106ATP hydrolysis coupled proton transport (GO:0015991)2.85661238
107insulin-like growth factor receptor signaling pathway (GO:0048009)2.85013327
108negative regulation of chondrocyte differentiation (GO:0032331)2.85003059
109hippo signaling (GO:0035329)2.83731628
110mesenchyme development (GO:0060485)2.83631341
111auditory receptor cell stereocilium organization (GO:0060088)2.82615292
112energy homeostasis (GO:0097009)2.82572006
113positive regulation of defense response to virus by host (GO:0002230)2.81682138
114embryonic forelimb morphogenesis (GO:0035115)2.81639985
115regulation of prostaglandin secretion (GO:0032306)2.81596275
116cell differentiation involved in kidney development (GO:0061005)2.81157069
117water-soluble vitamin biosynthetic process (GO:0042364)2.80696648
118mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.80521354
119hydrogen ion transmembrane transport (GO:1902600)2.80174746
120ATP synthesis coupled proton transport (GO:0015986)2.78578208
121energy coupled proton transport, down electrochemical gradient (GO:0015985)2.78578208
122proton transport (GO:0015992)2.78567881
123embryonic hindlimb morphogenesis (GO:0035116)2.78544615
124electron transport chain (GO:0022900)2.77979132
125regulation of secondary heart field cardioblast proliferation (GO:0003266)2.77729774
126regulation of cardioblast proliferation (GO:0003264)2.77729774
127limb morphogenesis (GO:0035108)2.76473783
128appendage morphogenesis (GO:0035107)2.76473783
129negative regulation of embryonic development (GO:0045992)2.75671992
130forelimb morphogenesis (GO:0035136)2.75568161
131hydrogen transport (GO:0006818)2.74483658
132positive regulation of fatty acid transport (GO:2000193)2.74013924
133face development (GO:0060324)2.73781398
134indole-containing compound metabolic process (GO:0042430)2.73760353
135cell surface receptor signaling pathway involved in heart development (GO:0061311)2.73009630
136Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.72772031
137L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72596429
138respiratory electron transport chain (GO:0022904)2.72526661
139outer ear morphogenesis (GO:0042473)2.71882110
140sulfur amino acid catabolic process (GO:0000098)2.70892876
141G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.70631549
142heart morphogenesis (GO:0003007)2.68981089
143positive regulation of heat generation (GO:0031652)2.68961770
144diterpenoid biosynthetic process (GO:0016102)2.67778212
145aromatic amino acid family catabolic process (GO:0009074)2.67599553
146negative regulation of striated muscle cell apoptotic process (GO:0010664)2.67454155
147regulation of heart morphogenesis (GO:2000826)2.67127272
148arginine catabolic process (GO:0006527)2.65310285
149regulation of organ formation (GO:0003156)2.64129116
150embryonic digestive tract morphogenesis (GO:0048557)2.63557108
151regulation of establishment of planar polarity (GO:0090175)2.63451790
152regulation of regulatory T cell differentiation (GO:0045589)2.61638666
153positive regulation of smoothened signaling pathway (GO:0045880)2.61223932
154multicellular organism reproduction (GO:0032504)2.60695635
155negative regulation of reactive oxygen species metabolic process (GO:2000378)2.59713525
156cytidine metabolic process (GO:0046087)2.59511327
157cytidine catabolic process (GO:0006216)2.59511327
158cytidine deamination (GO:0009972)2.59511327
159middle ear morphogenesis (GO:0042474)2.58699580
160interferon-gamma production (GO:0032609)2.58340204
161cellular ketone body metabolic process (GO:0046950)2.58246680
162GPI anchor metabolic process (GO:0006505)2.56513857
163exocrine pancreas development (GO:0031017)2.55513749
164non-canonical Wnt signaling pathway (GO:0035567)2.55011422
165bone remodeling (GO:0046849)2.54541752
166cell differentiation involved in metanephros development (GO:0072202)2.54114119
167myofibril assembly (GO:0030239)2.54097165
168regulation of memory T cell differentiation (GO:0043380)2.54018166
169adenosine metabolic process (GO:0046085)2.52910765
170detection of light stimulus involved in sensory perception (GO:0050962)2.52899280
171detection of light stimulus involved in visual perception (GO:0050908)2.52899280
172regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.50611336
173amino acid salvage (GO:0043102)2.50209320
174L-methionine salvage (GO:0071267)2.50209320
175L-methionine biosynthetic process (GO:0071265)2.50209320
176nicotinamide nucleotide biosynthetic process (GO:0019359)2.49741288
177pyridine nucleotide biosynthetic process (GO:0019363)2.49741288
178alanine transport (GO:0032328)2.49612419
179positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.49331521
180C-terminal protein lipidation (GO:0006501)2.48341443
181xenobiotic catabolic process (GO:0042178)2.46385839
182positive regulation of icosanoid secretion (GO:0032305)2.45963083
183axoneme assembly (GO:0035082)2.44941317
184piRNA metabolic process (GO:0034587)2.44102585
185positive regulation of chemokine biosynthetic process (GO:0045080)2.42956459
186C-terminal protein amino acid modification (GO:0018410)2.42952837
187aromatic amino acid family metabolic process (GO:0009072)2.39374158
188iron-sulfur cluster assembly (GO:0016226)2.38732058
189metallo-sulfur cluster assembly (GO:0031163)2.38732058
190regulation of cilium movement (GO:0003352)2.37182637
191polyol catabolic process (GO:0046174)2.36923659
192GPI anchor biosynthetic process (GO:0006506)2.36685141
193mitochondrial calcium ion transport (GO:0006851)2.35897006
194protein neddylation (GO:0045116)2.35132611
195protein K11-linked deubiquitination (GO:0035871)2.34567025
196regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.34236815
197synaptic transmission, cholinergic (GO:0007271)2.33434576
198signal peptide processing (GO:0006465)2.33145941
199cornea development in camera-type eye (GO:0061303)2.32261715
200sperm motility (GO:0030317)2.32062689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.08766897
2EED_16625203_ChIP-ChIP_MESCs_Mouse3.54325781
3VDR_22108803_ChIP-Seq_LS180_Human3.48901842
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.09183324
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.93531341
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80148616
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80148616
8PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.78302087
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.74920882
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.65587523
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.60614000
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52911310
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.52528336
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50265538
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45450411
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44727375
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.41826837
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.41603657
19RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.38737376
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37055255
21GBX2_23144817_ChIP-Seq_PC3_Human2.36293886
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.33035698
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32283564
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30042291
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.28357868
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.23173704
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21531321
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.21469839
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.15995356
30NOTCH1_21737748_ChIP-Seq_TLL_Human2.11525470
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.11461857
32EZH2_22144423_ChIP-Seq_EOC_Human2.11375447
33BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06280820
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.05430720
35TP53_20018659_ChIP-ChIP_R1E_Mouse1.99958252
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95894243
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.95707187
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92357983
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.90743283
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89692268
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.87384586
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.86898240
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85840098
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.85819362
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.79741382
46IGF1R_20145208_ChIP-Seq_DFB_Human1.79676661
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79511866
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77401380
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.74913236
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.72806574
51TP53_22573176_ChIP-Seq_HFKS_Human1.69354609
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68866908
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.65707788
54ISL1_27105846_Chip-Seq_CPCs_Mouse1.61573925
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.61045337
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60890685
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.60547068
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60319923
59MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60202048
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59446101
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.56162482
62MYC_18940864_ChIP-ChIP_HL60_Human1.55286848
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.53759067
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.53118517
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.53118517
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.52654243
67AR_20517297_ChIP-Seq_VCAP_Human1.52254915
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51603027
69NANOG_19829295_ChIP-Seq_ESCs_Human1.51030881
70SOX2_19829295_ChIP-Seq_ESCs_Human1.51030881
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50811267
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.50471957
73DROSHA_22980978_ChIP-Seq_HELA_Human1.48259902
74TAF2_19829295_ChIP-Seq_ESCs_Human1.47938969
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.47563764
76* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.47540477
77VDR_23849224_ChIP-Seq_CD4+_Human1.46395625
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.45685657
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45605072
80* MYC_19829295_ChIP-Seq_ESCs_Human1.44723771
81TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.44632904
82CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.37122092
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37076141
84GATA3_26560356_Chip-Seq_TH2_Human1.36204772
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35412931
86ETS1_20019798_ChIP-Seq_JURKAT_Human1.35290717
87TP53_18474530_ChIP-ChIP_U2OS_Human1.35283836
88ER_23166858_ChIP-Seq_MCF-7_Human1.34464607
89NCOR_22424771_ChIP-Seq_293T_Human1.34316857
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32010192
91HOXB7_26014856_ChIP-Seq_BT474_Human1.31632323
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30517582
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30137435
94NANOG_20526341_ChIP-Seq_ESCs_Human1.29290153
95IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29177091
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28683387
97P300_19829295_ChIP-Seq_ESCs_Human1.28587007
98* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28528014
99EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27819843
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27613369
101CBP_20019798_ChIP-Seq_JUKART_Human1.27613369
102PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27492490
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.26665424
104STAT1_20625510_ChIP-Seq_HELA_Human1.26299760
105ERA_21632823_ChIP-Seq_H3396_Human1.26125249
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25242147
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24822336
108POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23450001
109RNF2_27304074_Chip-Seq_NSC_Mouse1.23119753
110OCT4_20526341_ChIP-Seq_ESCs_Human1.22332789
111TAF15_26573619_Chip-Seq_HEK293_Human1.22310566
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21002704
113EWS_26573619_Chip-Seq_HEK293_Human1.19610897
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16942346
115AHR_22903824_ChIP-Seq_MCF-7_Human1.16552130
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16484400
117* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15490765
118TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.14978668
119SMAD_19615063_ChIP-ChIP_OVARY_Human1.14672149
120CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14609857
121EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.14294889
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13771074
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12191254
124SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11918134
125AR_25329375_ChIP-Seq_VCAP_Human1.11856125
126WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11824394
127CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11815608
128STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11523387
129PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.09607727
130FOXH1_21741376_ChIP-Seq_EPCs_Human1.09229457
131WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09182848
132CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08322087
133TCF4_22108803_ChIP-Seq_LS180_Human1.06434486
134SMAD3_21741376_ChIP-Seq_EPCs_Human1.06143007
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05891341
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05891341
137FOXH1_21741376_ChIP-Seq_ESCs_Human1.05852770
138HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05827729
139KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05534300
140ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.05302889
141SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03837532
142ARNT_22903824_ChIP-Seq_MCF-7_Human1.03370662
143ERG_20517297_ChIP-Seq_VCAP_Human1.02923784
144RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01856844
145ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01781133
146NFE2_27457419_Chip-Seq_LIVER_Mouse1.01312866
147VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01280160
148TCF4_18268006_ChIP-ChIP_LS174T_Human1.01245040
149CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00740042
150CTCF_20526341_ChIP-Seq_ESCs_Human1.00438763
151SMAD4_21799915_ChIP-Seq_A2780_Human1.00082316
152SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00077129
153SMAD4_21741376_ChIP-Seq_HESCs_Human1.00063663
154YY1_22570637_ChIP-Seq_MALME-3M_Human0.98973890
155ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98677278
156TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97928737
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97695917
158HTT_18923047_ChIP-ChIP_STHdh_Human0.97647759
159LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97417479
160DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96140630
161SMAD4_21741376_ChIP-Seq_EPCs_Human0.95840616
162P53_21459846_ChIP-Seq_SAOS-2_Human0.95223811
163FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95072887
164THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94413405
165YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93096285
166CRX_20693478_ChIP-Seq_RETINA_Mouse0.93034999
167GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93007475
168NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92241082
169CJUN_26792858_Chip-Seq_BT549_Human0.92077543
170NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91852931
171RBPJ_21746931_ChIP-Seq_IB4_Human0.91461055
172GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91277326
173PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90626866
174CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90342475
175ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89663155
176SALL1_21062744_ChIP-ChIP_HESCs_Human0.88623392
177LXR_22158963_ChIP-Seq_LIVER_Mouse0.88375141
178GF1B_26923725_Chip-Seq_HPCs_Mouse0.88349999
179SMAD3_21741376_ChIP-Seq_HESCs_Human0.88212056
180LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87935174
181AR_19668381_ChIP-Seq_PC3_Human0.87634230
182TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86499698
183BCAT_22108803_ChIP-Seq_LS180_Human0.85786853
184UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85282421
185ERG_21242973_ChIP-ChIP_JURKAT_Human0.84894662
186MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82878431
187RUNX2_22187159_ChIP-Seq_PCA_Human0.82438893
188NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81571573
189NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81571573

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology3.97720810
2MP0000566_synostosis3.93675618
3MP0003122_maternal_imprinting3.83464897
4MP0003195_calcinosis3.67070894
5MP0003941_abnormal_skin_development3.49509030
6MP0008438_abnormal_cutaneous_collagen3.27385772
7MP0002938_white_spotting3.07977366
8MP0003878_abnormal_ear_physiology2.96104561
9MP0005377_hearing/vestibular/ear_phenot2.96104561
10MP0003385_abnormal_body_wall2.85914580
11MP0010030_abnormal_orbit_morphology2.84793650
12MP0000372_irregular_coat_pigmentation2.79319615
13MP0004272_abnormal_basement_membrane2.73683645
14MP0005671_abnormal_response_to2.71107665
15MP0003806_abnormal_nucleotide_metabolis2.64126544
16MP0002837_dystrophic_cardiac_calcinosis2.62844880
17MP0004147_increased_porphyrin_level2.56780173
18MP0008875_abnormal_xenobiotic_pharmacok2.42063674
19MP0003121_genomic_imprinting2.37685332
20MP0010368_abnormal_lymphatic_system2.36568397
21MP0009053_abnormal_anal_canal2.36065760
22MP0009697_abnormal_copulation2.35875193
23MP0003942_abnormal_urinary_system2.33118255
24MP0003123_paternal_imprinting2.32752444
25MP0002249_abnormal_larynx_morphology2.29274601
26MP0001501_abnormal_sleep_pattern2.26736745
27MP0005075_abnormal_melanosome_morpholog2.26248414
28MP0005248_abnormal_Harderian_gland2.17551522
29MP0000049_abnormal_middle_ear2.12591571
30MP0004043_abnormal_pH_regulation2.06274439
31MP0009250_abnormal_appendicular_skeleto2.02237495
32MP0002148_abnormal_hypersensitivity_rea1.98225697
33MP0005275_abnormal_skin_tensile1.94678423
34MP0005174_abnormal_tail_pigmentation1.90221585
35MP0003787_abnormal_imprinting1.88643410
36MP0000678_abnormal_parathyroid_gland1.82086950
37MP0009785_altered_susceptibility_to1.81840987
38MP0009046_muscle_twitch1.80581401
39MP0002254_reproductive_system_inflammat1.80355885
40MP0005646_abnormal_pituitary_gland1.78098211
41MP0001968_abnormal_touch/_nociception1.77637057
42MP0005551_abnormal_eye_electrophysiolog1.75681264
43MP0001879_abnormal_lymphatic_vessel1.75169450
44MP0002282_abnormal_trachea_morphology1.71688979
45MP0001293_anophthalmia1.70751862
46MP0002108_abnormal_muscle_morphology1.69344121
47MP0005623_abnormal_meninges_morphology1.68279247
48MP0002736_abnormal_nociception_after1.68199846
49MP0010386_abnormal_urinary_bladder1.67293587
50MP0006072_abnormal_retinal_apoptosis1.65224084
51MP0003279_aneurysm1.62706840
52MP0002876_abnormal_thyroid_physiology1.62076708
53MP0006082_CNS_inflammation1.61581396
54MP0000762_abnormal_tongue_morphology1.59715163
55MP0005253_abnormal_eye_physiology1.59602420
56MP0005508_abnormal_skeleton_morphology1.58316268
57MP0008877_abnormal_DNA_methylation1.57954460
58MP0002932_abnormal_joint_morphology1.57824262
59MP0005410_abnormal_fertilization1.56939996
60MP0003011_delayed_dark_adaptation1.56457175
61MP0008872_abnormal_physiological_respon1.55623608
62MP0003705_abnormal_hypodermis_morpholog1.52146445
63MP0005257_abnormal_intraocular_pressure1.51557384
64MP0006292_abnormal_olfactory_placode1.50999999
65MP0003755_abnormal_palate_morphology1.48181598
66MP0003935_abnormal_craniofacial_develop1.47617486
67MP0009764_decreased_sensitivity_to1.47303510
68MP0004885_abnormal_endolymph1.46005011
69MP0000534_abnormal_ureter_morphology1.43503983
70MP0002877_abnormal_melanocyte_morpholog1.42206012
71MP0001346_abnormal_lacrimal_gland1.40979235
72MP0003646_muscle_fatigue1.39113529
73MP0002116_abnormal_craniofacial_bone1.35137789
74MP0001835_abnormal_antigen_presentation1.34208551
75MP0003136_yellow_coat_color1.34077251
76MP0003172_abnormal_lysosome_physiology1.32530827
77MP0005085_abnormal_gallbladder_physiolo1.31576348
78MP0009745_abnormal_behavioral_response1.31493568
79MP0003115_abnormal_respiratory_system1.29192381
80MP0000751_myopathy1.28868967
81MP0002233_abnormal_nose_morphology1.28415887
82MP0002109_abnormal_limb_morphology1.28217196
83MP0002127_abnormal_cardiovascular_syste1.27260073
84MP0003937_abnormal_limbs/digits/tail_de1.27070267
85MP0000767_abnormal_smooth_muscle1.26007209
86MP0000343_altered_response_to1.24936788
87MP0005187_abnormal_penis_morphology1.22387528
88MP0006138_congestive_heart_failure1.22249382
89MP0001958_emphysema1.21793890
90MP0003186_abnormal_redox_activity1.20480637
91MP0002095_abnormal_skin_pigmentation1.18135147
92MP0001188_hyperpigmentation1.17292657
93MP0000733_abnormal_muscle_development1.16865271
94MP0004134_abnormal_chest_morphology1.16565398
95MP0005387_immune_system_phenotype1.15554367
96MP0001790_abnormal_immune_system1.15554367
97MP0001485_abnormal_pinna_reflex1.14080197
98MP0002272_abnormal_nervous_system1.13770043
99MP0005084_abnormal_gallbladder_morpholo1.13113441
100MP0009840_abnormal_foam_cell1.12976762
101MP0002733_abnormal_thermal_nociception1.12952265
102MP0005058_abnormal_lysosome_morphology1.12504791
103MP0005171_absent_coat_pigmentation1.11324702
104MP0003119_abnormal_digestive_system1.08873285
105MP0001905_abnormal_dopamine_level1.08571743
106MP0006036_abnormal_mitochondrial_physio1.06879944
107MP0002693_abnormal_pancreas_physiology1.06850656
108MP0003252_abnormal_bile_duct1.06692616
109MP0005000_abnormal_immune_tolerance1.06663600
110MP0003075_altered_response_to1.06415489
111MP0004742_abnormal_vestibular_system1.06350180
112MP0005167_abnormal_blood-brain_barrier1.06211923
113MP0001984_abnormal_olfaction1.05319231
114MP0002138_abnormal_hepatobiliary_system1.05223714
115MP0000163_abnormal_cartilage_morphology1.04236804
116MP0000685_abnormal_immune_system1.03767549
117MP0002735_abnormal_chemical_nociception1.03295909
118MP0005365_abnormal_bile_salt1.02677485
119MP0002723_abnormal_immune_serum1.02507501
120MP0001986_abnormal_taste_sensitivity1.02345114
121MP0003943_abnormal_hepatobiliary_system1.02242864
122MP0002115_abnormal_skeleton_extremities1.02051327
123MP0002452_abnormal_antigen_presenting0.99872804
124MP0001800_abnormal_humoral_immune0.99421808
125MP0001286_abnormal_eye_development0.98554596
126MP0005645_abnormal_hypothalamus_physiol0.97900115
127MP0000428_abnormal_craniofacial_morphol0.97564835
128MP0005360_urolithiasis0.96874909
129MP0001764_abnormal_homeostasis0.96574742
130MP0005025_abnormal_response_to0.96400755
131MP0005083_abnormal_biliary_tract0.95490554
132MP0003938_abnormal_ear_development0.95190047
133MP0003879_abnormal_hair_cell0.94663825
134MP0001970_abnormal_pain_threshold0.93989801
135MP0002229_neurodegeneration0.93313909
136MP0002132_abnormal_respiratory_system0.91760065
137MP0004510_myositis0.91711398
138MP0000371_diluted_coat_color0.91467476
139MP0000432_abnormal_head_morphology0.91243412
140MP0000230_abnormal_systemic_arterial0.90977169
141MP0005332_abnormal_amino_acid0.90059945
142MP0002277_abnormal_respiratory_mucosa0.89991318
143MP0002139_abnormal_hepatobiliary_system0.89096991
144MP0010329_abnormal_lipoprotein_level0.88835810
145MP0001919_abnormal_reproductive_system0.88378691
146MP0009672_abnormal_birth_weight0.87047021
147MP0002098_abnormal_vibrissa_morphology0.86902192
148MP0001845_abnormal_inflammatory_respons0.86878637
149MP0005636_abnormal_mineral_homeostasis0.86333377
150MP0000613_abnormal_salivary_gland0.85582753
151MP0002092_abnormal_eye_morphology0.85566911
152MP0002064_seizures0.85345333
153MP0000516_abnormal_urinary_system0.85304668
154MP0005367_renal/urinary_system_phenotyp0.85304668
155MP0002572_abnormal_emotion/affect_behav0.84580814
156MP0002113_abnormal_skeleton_development0.83931205
157MP0002697_abnormal_eye_size0.83289943
158MP0009643_abnormal_urine_homeostasis0.82438683
159MP0002557_abnormal_social/conspecific_i0.82327060
160MP0001663_abnormal_digestive_system0.80637411
161MP0004084_abnormal_cardiac_muscle0.80468297
162MP0004215_abnormal_myocardial_fiber0.80058563
163MP0003724_increased_susceptibility_to0.79629901
164MP0004142_abnormal_muscle_tone0.79582569
165MP0003718_maternal_effect0.78933208
166MP0008775_abnormal_heart_ventricle0.78840904
167MP0002925_abnormal_cardiovascular_devel0.78816557
168MP0003283_abnormal_digestive_organ0.78437164
169MP0002972_abnormal_cardiac_muscle0.78248593
170MP0000383_abnormal_hair_follicle0.77976746
171MP0005379_endocrine/exocrine_gland_phen0.77259514
172MP0005310_abnormal_salivary_gland0.77200302
173MP0000537_abnormal_urethra_morphology0.77122808
174MP0002114_abnormal_axial_skeleton0.76518793
175MP0004133_heterotaxia0.76447377
176MP0002896_abnormal_bone_mineralization0.76364868
177MP0003567_abnormal_fetal_cardiomyocyte0.75767138
178MP0000026_abnormal_inner_ear0.74841026
179MP0009703_decreased_birth_body0.74052971
180MP0002177_abnormal_outer_ear0.72704985
181MP0001175_abnormal_lung_morphology0.71606351
182MP0002102_abnormal_ear_morphology0.71442157
183MP0002163_abnormal_gland_morphology0.71366297
184MP0000579_abnormal_nail_morphology0.70944651
185MP0002128_abnormal_blood_circulation0.68484199
186MP0006276_abnormal_autonomic_nervous0.68004806
187MP0001614_abnormal_blood_vessel0.65393588
188MP0002111_abnormal_tail_morphology0.65185134
189MP0001340_abnormal_eyelid_morphology0.65115160
190MP0001177_atelectasis0.63696668

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)5.43224070
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.43224070
3Abnormality of the parietal bone (HP:0002696)4.56693014
4Follicular hyperkeratosis (HP:0007502)4.30541719
5Abnormality of the 4th metacarpal (HP:0010012)4.29361180
6Midline defect of the nose (HP:0004122)3.98820774
7Renal duplication (HP:0000075)3.60472545
8Pancreatic cysts (HP:0001737)3.54092684
9Broad metatarsal (HP:0001783)3.51271269
10Abnormality of midbrain morphology (HP:0002418)3.35261612
11Molar tooth sign on MRI (HP:0002419)3.35261612
12Congenital stationary night blindness (HP:0007642)3.26174246
13Acute necrotizing encephalopathy (HP:0006965)3.24468770
14Attenuation of retinal blood vessels (HP:0007843)3.24351685
15Hepatoblastoma (HP:0002884)3.22837423
16Alopecia of scalp (HP:0002293)3.21697730
17Abnormality of glycolipid metabolism (HP:0010969)3.18463857
18Abnormality of liposaccharide metabolism (HP:0010968)3.18463857
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.18463857
20Supernumerary ribs (HP:0005815)3.18202888
21Shallow orbits (HP:0000586)3.13298783
22Mitochondrial inheritance (HP:0001427)3.11583066
233-Methylglutaconic aciduria (HP:0003535)3.07009045
24Abnormality of the renal cortex (HP:0011035)3.05495963
25Absent eyelashes (HP:0000561)3.01403666
26Stomatitis (HP:0010280)2.95733397
27Pancreatic fibrosis (HP:0100732)2.94744871
28Absent eyebrow (HP:0002223)2.94207613
29Hypothermia (HP:0002045)2.94174380
30Acute encephalopathy (HP:0006846)2.93705422
31Vacuolated lymphocytes (HP:0001922)2.92860967
32Increased CSF lactate (HP:0002490)2.92250446
33Progressive macrocephaly (HP:0004481)2.92248442
34Polydipsia (HP:0001959)2.90618259
35Abnormal drinking behavior (HP:0030082)2.90618259
36Abnormal mitochondria in muscle tissue (HP:0008316)2.88063560
37Protrusio acetabuli (HP:0003179)2.87339840
38Cutaneous finger syndactyly (HP:0010554)2.84661994
39True hermaphroditism (HP:0010459)2.82310216
40Syringomyelia (HP:0003396)2.79506421
41Spinal cord lesions (HP:0100561)2.79506421
42Hypomagnesemia (HP:0002917)2.76532345
43Hepatic necrosis (HP:0002605)2.76335051
44Abolished electroretinogram (ERG) (HP:0000550)2.75969434
45Supernumerary bones of the axial skeleton (HP:0009144)2.75891356
46Hepatocellular necrosis (HP:0001404)2.74771016
47Mesomelia (HP:0003027)2.73992934
48Polyuria (HP:0000103)2.67430921
49Optic disc pallor (HP:0000543)2.67210120
50Trigonocephaly (HP:0000243)2.67105315
51Abnormal rod and cone electroretinograms (HP:0008323)2.64847842
52Asymmetry of the thorax (HP:0001555)2.62882312
53Renal cortical cysts (HP:0000803)2.62240105
54Nephronophthisis (HP:0000090)2.61539028
55Premature rupture of membranes (HP:0001788)2.57620574
56Cutaneous syndactyly (HP:0012725)2.54817920
57Lymphangioma (HP:0100764)2.53868007
58Short middle phalanx of the 5th finger (HP:0004220)2.53694751
59Type 1 muscle fiber predominance (HP:0003803)2.51417661
60Renovascular hypertension (HP:0100817)2.51111391
61Sprengel anomaly (HP:0000912)2.50992644
62Abnormality of the renal medulla (HP:0100957)2.50259343
63Large for gestational age (HP:0001520)2.46914590
64Tubular atrophy (HP:0000092)2.45091335
65Increased neuronal autofluorescent lipopigment (HP:0002074)2.39619505
66Pulmonary artery stenosis (HP:0004415)2.39378065
67Morphological abnormality of the middle ear (HP:0008609)2.37784763
68Coronal craniosynostosis (HP:0004440)2.37294625
69Bladder diverticulum (HP:0000015)2.37289134
70Increased cerebral lipofuscin (HP:0011813)2.37144648
71Abnormality of the distal phalanx of the thumb (HP:0009617)2.37070341
72Congenital sensorineural hearing impairment (HP:0008527)2.36189912
73Generalized aminoaciduria (HP:0002909)2.32082241
74Pendular nystagmus (HP:0012043)2.32040879
75Skull defect (HP:0001362)2.31662110
76Flat cornea (HP:0007720)2.31082593
77Unilateral renal agenesis (HP:0000122)2.29789634
78Methylmalonic aciduria (HP:0012120)2.28558181
79Decreased central vision (HP:0007663)2.25319990
80Broad toe (HP:0001837)2.24439412
81Tetany (HP:0001281)2.23129081
82Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22501621
83Abnormality of the nasolacrimal system (HP:0000614)2.20969001
84Enlarged kidneys (HP:0000105)2.20589555
85Renal dysplasia (HP:0000110)2.19352328
86Shawl scrotum (HP:0000049)2.18944824
87Abnormality of incisor morphology (HP:0011063)2.18805278
88Abnormality of magnesium homeostasis (HP:0004921)2.18299835
89Clumsiness (HP:0002312)2.16410900
90Abnormal urine output (HP:0012590)2.16089201
91Skin pits (HP:0100276)2.14842629
92Hypoplasia of the fovea (HP:0007750)2.12979217
93Aplasia/Hypoplasia of the fovea (HP:0008060)2.12979217
94Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11744540
95Diastasis recti (HP:0001540)2.11331081
96Methylmalonic acidemia (HP:0002912)2.10222309
97Neonatal hypoglycemia (HP:0001998)2.10139679
98Narrow nasal bridge (HP:0000446)2.09695120
99Ketosis (HP:0001946)2.09389763
100Wrist flexion contracture (HP:0001239)2.09315603
101Increased number of teeth (HP:0011069)2.08467274
102Wide anterior fontanel (HP:0000260)2.06115626
103Ketoacidosis (HP:0001993)2.05253001
104Congenital, generalized hypertrichosis (HP:0004540)2.05028172
105Abnormality of the diencephalon (HP:0010662)2.04516672
106Increased serum lactate (HP:0002151)2.04136343
107Recurrent corneal erosions (HP:0000495)2.03497968
108Lipid accumulation in hepatocytes (HP:0006561)2.02622686
109Aortic dissection (HP:0002647)2.01988587
110Cystic liver disease (HP:0006706)2.01913780
111Abnormality of eosinophils (HP:0001879)2.01887705
112Abnormality of the phalanges of the hallux (HP:0010057)2.01532330
113Long eyelashes (HP:0000527)2.00997599
114Vitreoretinal degeneration (HP:0000655)2.00175977
115Respiratory failure (HP:0002878)1.98441176
116Preauricular pit (HP:0004467)1.98329444
117Periauricular skin pits (HP:0100277)1.98329444
118Renal Fanconi syndrome (HP:0001994)1.97989413
119Aplasia/hypoplasia of the uterus (HP:0008684)1.97959875
120Patchy hypopigmentation of hair (HP:0011365)1.96925792
121Congenital hepatic fibrosis (HP:0002612)1.96639364
122Type II lissencephaly (HP:0007260)1.96048837
123Lactic acidosis (HP:0003128)1.95372769
124Abnormality of renal excretion (HP:0011036)1.95101534
125Abnormality of the lacrimal duct (HP:0011481)1.94741397
126Albinism (HP:0001022)1.94671321
127Ectopia lentis (HP:0001083)1.93782233
128IgG deficiency (HP:0004315)1.93754263
129Medial flaring of the eyebrow (HP:0010747)1.92920007
130Abnormality of alanine metabolism (HP:0010916)1.91743305
131Hyperalaninemia (HP:0003348)1.91743305
132Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91743305
133Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91499988
134Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91499988
135Soft skin (HP:0000977)1.89817948
136Preaxial foot polydactyly (HP:0001841)1.88953477
137Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88503991
138Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.86783796
139Mesangial abnormality (HP:0001966)1.86631182
140Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86578441
141White forelock (HP:0002211)1.86306041
142Abnormal ossification of hand bones (HP:0005921)1.86159516
143Increased hepatocellular lipid droplets (HP:0006565)1.85269608
144Abnormality of the incisor (HP:0000676)1.85241032
145Elfin facies (HP:0004428)1.84545851
146Fragile skin (HP:0001030)1.83722752
147Hypoplastic left heart (HP:0004383)1.83330703
148Short phalanx of the thumb (HP:0009660)1.83248771
149Abnormality of macular pigmentation (HP:0008002)1.83108161
150Tongue fasciculations (HP:0001308)1.83000581
151Myelomeningocele (HP:0002475)1.82536351
152Protruding ear (HP:0000411)1.82081616
153Spinal rigidity (HP:0003306)1.81926860
154Aplasia cutis congenita (HP:0001057)1.81901867
155Chronic hepatic failure (HP:0100626)1.81711742
156Delayed CNS myelination (HP:0002188)1.81677865
157Omphalocele (HP:0001539)1.81363556
158Dicarboxylic aciduria (HP:0003215)1.80541259
159Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80541259
160Cerebral edema (HP:0002181)1.80371862
161Progressive microcephaly (HP:0000253)1.80038227
162Metabolic alkalosis (HP:0200114)1.77308642
163Keratoconus (HP:0000563)1.77305508
164Increased corneal curvature (HP:0100692)1.77305508
165Neoplasm of the heart (HP:0100544)1.77056167
166Abnormality of the fovea (HP:0000493)1.76906698
167Turricephaly (HP:0000262)1.76631372
168Slender build (HP:0001533)1.76442835
169Abnormality of the intervertebral disk (HP:0005108)1.75963847
170Atrophic scars (HP:0001075)1.75405239
171Mitral stenosis (HP:0001718)1.75123661
172Furrowed tongue (HP:0000221)1.74869543
173Abnormal hand bone ossification (HP:0010660)1.74866997
174Increased connective tissue (HP:0009025)1.74212255
175Hip contracture (HP:0003273)1.73939550
176Autoimmune thrombocytopenia (HP:0001973)1.73663961
177Hypoalbuminemia (HP:0003073)1.73402480
178Abnormal albumin level (HP:0012116)1.73402480
179Severe muscular hypotonia (HP:0006829)1.73138334
180Ankle contracture (HP:0006466)1.72477635
181Narrow palate (HP:0000189)1.71448954
182Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71369162
183Parakeratosis (HP:0001036)1.69320610
184Chorioretinal atrophy (HP:0000533)1.68990239
185Lethargy (HP:0001254)1.68618423
186Deviation of the hallux (HP:0010051)1.68322617
187Inability to walk (HP:0002540)1.67193361
188Short 5th finger (HP:0009237)1.65488321
189Nasolacrimal duct obstruction (HP:0000579)1.64599018
190Bell-shaped thorax (HP:0001591)1.64399485
191Bilateral sensorineural hearing impairment (HP:0008619)1.63911226
192Hypoplastic labia majora (HP:0000059)1.63741566
193Hypoventilation (HP:0002791)1.62944227
194Absent hair (HP:0002298)1.62230762
195Down-sloping shoulders (HP:0200021)1.61912737
196Broad forehead (HP:0000337)1.60479077
197Hypoplasia of the iris (HP:0007676)1.59810333
198Broad long bones (HP:0005622)1.59683219
199Ectopic anus (HP:0004397)1.59527000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.33561339
2BRD44.16047320
3SIK33.89391705
4ADRBK23.49717064
5TXK3.37602918
6STK38L3.18914202
7SIK13.10365705
8TAOK33.00259148
9EPHB22.94794480
10TIE12.81730499
11MATK2.76565561
12KIT2.66781639
13LATS12.62941756
14PINK12.58833652
15ERBB32.58447402
16MAP4K22.41175447
17MKNK22.28001991
18SIK22.19214265
19WNK42.17061115
20CDK122.09495081
21AKT32.04648050
22TLK11.94160798
23MKNK11.88402568
24BCKDK1.84131747
25PDGFRA1.66055747
26ZAK1.64520703
27IKBKB1.58439786
28CASK1.57077192
29DDR21.55294762
30MYLK1.54605614
31STK391.53830379
32MAP3K141.53798137
33GRK71.53327272
34MAP2K61.52078260
35MST41.49147769
36SGK21.48785885
37VRK21.47287743
38ACVR1B1.47087415
39LATS21.46517243
40INSRR1.43695137
41MAPK131.40645101
42OBSCN1.37288388
43TAOK21.36194893
44PIK3CA1.33680054
45OXSR11.29154064
46STK31.26726816
47PHKG11.26724384
48PHKG21.26724384
49YES11.23971062
50MAPKAPK31.23664819
51PRPF4B1.22753760
52CSNK1G31.17915093
53STK241.11915366
54SGK31.08115110
55MUSK1.06526850
56CAMK41.02790703
57CLK11.01454870
58TESK21.01364183
59CSNK1G20.99165841
60FGFR20.96680809
61MAP4K10.96010567
62CSNK1G10.95280824
63TBK10.95083488
64ABL20.94068326
65NME20.94038736
66EPHA30.92902517
67SRPK10.91951676
68EPHA20.91559607
69GRK10.91355681
70TGFBR10.89739073
71ADRBK10.89639153
72SGK2230.89327899
73SGK4940.89327899
74RIPK10.88677875
75CHUK0.87687533
76IRAK30.86954589
77VRK10.84781794
78PLK40.84207636
79KDR0.83972930
80MAP3K40.83458202
81NEK90.81735213
82WNK30.81289550
83CAMKK20.81064437
84PKN10.80834468
85STK160.80818226
86TNK20.79765740
87MAPK150.79655549
88TTN0.79454183
89NTRK20.78518292
90MARK30.78307470
91IKBKE0.77730371
92EIF2AK20.74804024
93PRKCQ0.74255336
94TRIB30.73644668
95PAK40.73200851
96FER0.72516827
97CDK70.72291366
98TRIM280.71276491
99NME10.69091976
100LYN0.67883144
101MAP3K100.66962061
102PRKCG0.66708057
103DYRK20.66540967
104TEC0.65744954
105FGFR40.64765748
106CDK80.64605326
107FGFR10.64573208
108NLK0.63938570
109TNIK0.63882875
110ITK0.62936242
111TGFBR20.62822212
112BMPR1B0.62412649
113DAPK20.62136251
114SYK0.60872515
115LIMK10.57464095
116PTK60.57445809
117RPS6KA50.57288741
118PRKCE0.57181975
119BCR0.55952004
120DAPK10.53985947
121STK40.53978384
122MAPK70.53307941
123AKT10.53305338
124ICK0.52917596
125WNK10.52724901
126BMPR20.52430857
127CSF1R0.52381032
128MAPK120.49190398
129LCK0.48816197
130CSNK1A10.48327800
131MAPKAPK50.47593368
132PRKD30.47439841
133PKN20.47244491
134RPS6KA60.47234836
135EIF2AK30.45588735
136NTRK30.45559271
137CDK30.45542378
138TRPM70.43616919
139MARK20.43615990
140CCNB10.43324359
141PRKAA20.42576585
142PRKCI0.42518087
143ERBB20.41912777
144PDGFRB0.41143256
145CDC42BPA0.40805771
146PRKCH0.40410483
147NEK20.40404206
148PRKCA0.40323763
149BMX0.39460994
150MAP3K110.39379529
151PLK20.39343775
152MAPK10.39108938
153IGF1R0.38506246
154PRKACA0.37907738
155PAK30.37853132
156CAMK2A0.36927580
157PTK2B0.36657149
158MAP2K70.36546109
159JAK30.36067955
160CAMK1D0.35891653
161NUAK10.35872435
162PIM20.35076134
163PRKCZ0.35031340
164CSNK1A1L0.34846195
165ROCK10.34169081
166PRKG10.33052601
167BTK0.32827604
168MTOR0.32205638
169MAPK80.31385893
170PRKACB0.30634836
171ABL10.28262814

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.89631238
2Oxidative phosphorylation_Homo sapiens_hsa001903.34056286
3Hedgehog signaling pathway_Homo sapiens_hsa043403.22842409
4ECM-receptor interaction_Homo sapiens_hsa045122.43121863
5Collecting duct acid secretion_Homo sapiens_hsa049662.29772503
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.29156928
7Parkinsons disease_Homo sapiens_hsa050122.25317137
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.23803250
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22152985
10Notch signaling pathway_Homo sapiens_hsa043302.20416682
11Lysine degradation_Homo sapiens_hsa003102.15186978
12Type I diabetes mellitus_Homo sapiens_hsa049402.09662463
13Rheumatoid arthritis_Homo sapiens_hsa053232.09550595
14Steroid hormone biosynthesis_Homo sapiens_hsa001402.04603865
15Proteasome_Homo sapiens_hsa030501.99552844
16Protein digestion and absorption_Homo sapiens_hsa049741.94377540
17Asthma_Homo sapiens_hsa053101.90895753
18Phototransduction_Homo sapiens_hsa047441.85230121
19Protein export_Homo sapiens_hsa030601.84714880
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.82731585
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.80308034
22Fatty acid degradation_Homo sapiens_hsa000711.79140251
23Dilated cardiomyopathy_Homo sapiens_hsa054141.78900868
24Arginine biosynthesis_Homo sapiens_hsa002201.77715585
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74101782
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.72176135
27Hippo signaling pathway_Homo sapiens_hsa043901.69125678
28Adherens junction_Homo sapiens_hsa045201.68284983
29Complement and coagulation cascades_Homo sapiens_hsa046101.65925062
30Tryptophan metabolism_Homo sapiens_hsa003801.61786671
31Viral myocarditis_Homo sapiens_hsa054161.61390529
32Linoleic acid metabolism_Homo sapiens_hsa005911.60351898
33Axon guidance_Homo sapiens_hsa043601.59056748
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58314405
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55775761
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51771999
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48849322
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.48686700
39Alzheimers disease_Homo sapiens_hsa050101.48505120
40Primary immunodeficiency_Homo sapiens_hsa053401.45880123
41Phenylalanine metabolism_Homo sapiens_hsa003601.45218317
42Wnt signaling pathway_Homo sapiens_hsa043101.43717868
43beta-Alanine metabolism_Homo sapiens_hsa004101.42137284
44RNA polymerase_Homo sapiens_hsa030201.40817102
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38292457
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37834301
47Lysosome_Homo sapiens_hsa041421.36949545
48Ether lipid metabolism_Homo sapiens_hsa005651.34937244
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34556861
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33504014
51PPAR signaling pathway_Homo sapiens_hsa033201.31181204
52Fatty acid metabolism_Homo sapiens_hsa012121.31151665
53Peroxisome_Homo sapiens_hsa041461.30613974
54Chemical carcinogenesis_Homo sapiens_hsa052041.30263930
55Focal adhesion_Homo sapiens_hsa045101.25332927
56TGF-beta signaling pathway_Homo sapiens_hsa043501.24435550
57Huntingtons disease_Homo sapiens_hsa050161.23436415
58Homologous recombination_Homo sapiens_hsa034401.23136945
59Graft-versus-host disease_Homo sapiens_hsa053321.22887323
60Retinol metabolism_Homo sapiens_hsa008301.22168343
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20591512
62Caffeine metabolism_Homo sapiens_hsa002321.19044520
63Selenocompound metabolism_Homo sapiens_hsa004501.17297208
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16438625
65Allograft rejection_Homo sapiens_hsa053301.13689127
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13234368
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12073926
68Antigen processing and presentation_Homo sapiens_hsa046121.10924760
69Ovarian steroidogenesis_Homo sapiens_hsa049131.10564328
70Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07681893
71SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06468633
72Melanoma_Homo sapiens_hsa052181.04052759
73PI3K-Akt signaling pathway_Homo sapiens_hsa041511.02387816
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01992768
75Arginine and proline metabolism_Homo sapiens_hsa003301.00685927
76Amoebiasis_Homo sapiens_hsa051460.97172005
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.96088313
78Pathways in cancer_Homo sapiens_hsa052000.94169035
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94060694
80Starch and sucrose metabolism_Homo sapiens_hsa005000.93716499
81Sulfur metabolism_Homo sapiens_hsa009200.91664582
82Prostate cancer_Homo sapiens_hsa052150.91294486
83Butanoate metabolism_Homo sapiens_hsa006500.90663906
84Histidine metabolism_Homo sapiens_hsa003400.90198440
85Cardiac muscle contraction_Homo sapiens_hsa042600.89759403
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89430418
87Proteoglycans in cancer_Homo sapiens_hsa052050.89255548
88Small cell lung cancer_Homo sapiens_hsa052220.89127892
89Arachidonic acid metabolism_Homo sapiens_hsa005900.87602398
90Bile secretion_Homo sapiens_hsa049760.87472479
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.86329476
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83686717
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83470769
94Basal transcription factors_Homo sapiens_hsa030220.81987528
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.81984541
96Autoimmune thyroid disease_Homo sapiens_hsa053200.81476469
97Staphylococcus aureus infection_Homo sapiens_hsa051500.79666770
98Hematopoietic cell lineage_Homo sapiens_hsa046400.79257669
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78815348
100Melanogenesis_Homo sapiens_hsa049160.77938029
101Fanconi anemia pathway_Homo sapiens_hsa034600.77551262
102Propanoate metabolism_Homo sapiens_hsa006400.76555556
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75817358
104Nitrogen metabolism_Homo sapiens_hsa009100.75528868
105Fatty acid elongation_Homo sapiens_hsa000620.74046874
106MicroRNAs in cancer_Homo sapiens_hsa052060.73439133
107Taste transduction_Homo sapiens_hsa047420.71559730
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71136823
109Metabolic pathways_Homo sapiens_hsa011000.70637564
110Nicotine addiction_Homo sapiens_hsa050330.70284733
111Purine metabolism_Homo sapiens_hsa002300.70042370
112Tyrosine metabolism_Homo sapiens_hsa003500.69720029
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69378332
114Glutathione metabolism_Homo sapiens_hsa004800.64170237
115Other glycan degradation_Homo sapiens_hsa005110.62993663
116One carbon pool by folate_Homo sapiens_hsa006700.62715676
117Insulin resistance_Homo sapiens_hsa049310.61794015
118Regulation of autophagy_Homo sapiens_hsa041400.61360515
119Synaptic vesicle cycle_Homo sapiens_hsa047210.60854487
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59531941
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56517576
122HTLV-I infection_Homo sapiens_hsa051660.56321456
123Olfactory transduction_Homo sapiens_hsa047400.55827709
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53972803
125TNF signaling pathway_Homo sapiens_hsa046680.53507251
126Pyrimidine metabolism_Homo sapiens_hsa002400.53098339
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51579760
128Prion diseases_Homo sapiens_hsa050200.50772924
129Rap1 signaling pathway_Homo sapiens_hsa040150.48349542
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48226764
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47275228
132RNA degradation_Homo sapiens_hsa030180.47046974
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.46873700
134Vitamin digestion and absorption_Homo sapiens_hsa049770.46240796
135Toxoplasmosis_Homo sapiens_hsa051450.44371472
136Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42729828
137ABC transporters_Homo sapiens_hsa020100.41936099
138African trypanosomiasis_Homo sapiens_hsa051430.41171996
139Ras signaling pathway_Homo sapiens_hsa040140.40997673
140Herpes simplex infection_Homo sapiens_hsa051680.40978961
141Morphine addiction_Homo sapiens_hsa050320.40906967
142Tight junction_Homo sapiens_hsa045300.40844449
143Sphingolipid metabolism_Homo sapiens_hsa006000.40474844
144Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39822571
145Mineral absorption_Homo sapiens_hsa049780.38656115
146Sulfur relay system_Homo sapiens_hsa041220.38046103
147GABAergic synapse_Homo sapiens_hsa047270.37871953
148Insulin secretion_Homo sapiens_hsa049110.37036374
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35082762
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35043369
151Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34333475
152Cysteine and methionine metabolism_Homo sapiens_hsa002700.33988250
153Legionellosis_Homo sapiens_hsa051340.33641168
154Serotonergic synapse_Homo sapiens_hsa047260.32041442
155cAMP signaling pathway_Homo sapiens_hsa040240.31647886
156Drug metabolism - other enzymes_Homo sapiens_hsa009830.31302824
157Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30914362
158Endometrial cancer_Homo sapiens_hsa052130.28371322
159Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27432360
160RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27075927
161Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26099151

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