KCNT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)6.54374655
2regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)6.00850260
3pyrimidine nucleobase catabolic process (GO:0006208)5.87978927
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.84104336
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.68702374
6neuron cell-cell adhesion (GO:0007158)5.67961230
7presynaptic membrane assembly (GO:0097105)5.66557479
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.64208905
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.52293808
10regulation of glutamate receptor signaling pathway (GO:1900449)5.47472319
11neurotransmitter-gated ion channel clustering (GO:0072578)5.44400606
12locomotory exploration behavior (GO:0035641)5.44262525
13synaptic vesicle exocytosis (GO:0016079)5.28484550
14protein localization to synapse (GO:0035418)5.20499071
15glutamate secretion (GO:0014047)5.16518837
16presynaptic membrane organization (GO:0097090)4.99442342
17postsynaptic membrane organization (GO:0001941)4.98547963
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.90076043
19behavioral response to nicotine (GO:0035095)4.89866031
20regulation of synaptic vesicle exocytosis (GO:2000300)4.76392449
21nucleobase catabolic process (GO:0046113)4.70427984
22neuron-neuron synaptic transmission (GO:0007270)4.62752570
23synaptic transmission, glutamatergic (GO:0035249)4.59356906
24glutamate receptor signaling pathway (GO:0007215)4.52621569
25startle response (GO:0001964)4.47237457
26neuronal action potential propagation (GO:0019227)4.43854219
27gamma-aminobutyric acid signaling pathway (GO:0007214)4.35920451
28negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.32544426
29long-term synaptic potentiation (GO:0060291)4.29301097
30positive regulation of synapse maturation (GO:0090129)4.28578773
31negative regulation of synaptic transmission, GABAergic (GO:0032229)4.21069268
32regulation of synaptic vesicle transport (GO:1902803)4.21059980
33neurotransmitter secretion (GO:0007269)4.19090185
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.18004851
35exploration behavior (GO:0035640)4.17455684
36regulation of excitatory postsynaptic membrane potential (GO:0060079)4.09593225
37cerebellar granule cell differentiation (GO:0021707)4.08835772
38regulation of synaptic transmission, glutamatergic (GO:0051966)4.07309967
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.99887913
40response to histamine (GO:0034776)3.99113408
41regulation of postsynaptic membrane potential (GO:0060078)3.94240585
42regulation of long-term neuronal synaptic plasticity (GO:0048169)3.91923201
43synaptic vesicle maturation (GO:0016188)3.87812321
44retinal ganglion cell axon guidance (GO:0031290)3.81760217
45regulation of neuronal synaptic plasticity (GO:0048168)3.78048248
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.74940796
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.74195124
48neuron recognition (GO:0008038)3.72214934
49positive regulation of membrane potential (GO:0045838)3.71051676
50regulation of synapse maturation (GO:0090128)3.68863334
51behavioral fear response (GO:0001662)3.68609014
52behavioral defense response (GO:0002209)3.68609014
53positive regulation of synapse assembly (GO:0051965)3.66156107
54long-term memory (GO:0007616)3.62432135
55regulation of synaptic plasticity (GO:0048167)3.59391934
56olfactory bulb development (GO:0021772)3.56838763
57fear response (GO:0042596)3.52308365
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.43422944
59gamma-aminobutyric acid transport (GO:0015812)3.39064180
60negative regulation of dendrite morphogenesis (GO:0050774)3.37896869
61positive regulation of neurotransmitter secretion (GO:0001956)3.37534424
62behavioral response to cocaine (GO:0048148)3.36849094
63regulation of glutamate secretion (GO:0014048)3.36672154
64axonal fasciculation (GO:0007413)3.33446321
65neurotransmitter transport (GO:0006836)3.32433998
66regulation of neurotransmitter secretion (GO:0046928)3.32160591
67synaptic vesicle endocytosis (GO:0048488)3.27761686
68positive regulation of synaptic transmission (GO:0050806)3.25929301
69mechanosensory behavior (GO:0007638)3.22518661
70membrane depolarization (GO:0051899)3.22213152
71limb bud formation (GO:0060174)3.21494214
72intraciliary transport (GO:0042073)3.16565705
73regulation of female receptivity (GO:0045924)3.16024516
74central nervous system projection neuron axonogenesis (GO:0021952)3.15192724
75negative regulation of axon guidance (GO:1902668)3.15065100
76cerebellar Purkinje cell differentiation (GO:0021702)3.15026679
77cellular response to ammonium ion (GO:0071242)3.13451296
78negative regulation of dendrite development (GO:2000171)3.13110545
79learning (GO:0007612)3.11499533
80female mating behavior (GO:0060180)3.10648239
81auditory behavior (GO:0031223)3.10500816
82regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10357277
83regulation of neurotransmitter levels (GO:0001505)3.08874345
84detection of calcium ion (GO:0005513)3.08609075
85regulation of synapse assembly (GO:0051963)3.08504080
86calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.06587354
87proline transport (GO:0015824)3.04735916
88regulation of dendritic spine morphogenesis (GO:0061001)3.04725884
89regulation of synapse structural plasticity (GO:0051823)3.04631996
90transmission of nerve impulse (GO:0019226)3.04597769
91regulation of voltage-gated calcium channel activity (GO:1901385)3.03307931
92regulation of synaptic transmission (GO:0050804)3.03227197
93membrane hyperpolarization (GO:0060081)3.03058483
94regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03026321
95nonmotile primary cilium assembly (GO:0035058)3.01681387
96synaptic transmission (GO:0007268)3.01480843
97transferrin transport (GO:0033572)2.99687006
98synapse assembly (GO:0007416)2.98449340
99protein localization to cilium (GO:0061512)2.97046747
100negative regulation of amino acid transport (GO:0051956)2.96943030
101cochlea development (GO:0090102)2.95455813
102activation of protein kinase A activity (GO:0034199)2.94389242
103membrane assembly (GO:0071709)2.93852197
104membrane depolarization during action potential (GO:0086010)2.93415029
105regulation of neurotransmitter transport (GO:0051588)2.92187910
106dendritic spine morphogenesis (GO:0060997)2.91978505
107ATP hydrolysis coupled proton transport (GO:0015991)2.90993028
108energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.90993028
109intraspecies interaction between organisms (GO:0051703)2.89550520
110social behavior (GO:0035176)2.89550520
111regulation of vesicle fusion (GO:0031338)2.89475685
112epithelial cilium movement (GO:0003351)2.88587621
113innervation (GO:0060384)2.87470636
114ganglion development (GO:0061548)2.86565596
115spinal cord development (GO:0021510)2.84584898
116epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.78460894
117central nervous system neuron axonogenesis (GO:0021955)2.76800050
118cerebral cortex radially oriented cell migration (GO:0021799)2.76206582
119negative regulation of translation, ncRNA-mediated (GO:0040033)2.75795601
120regulation of translation, ncRNA-mediated (GO:0045974)2.75795601
121negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.75795601
122axon extension involved in axon guidance (GO:0048846)2.74194252
123neuron projection extension involved in neuron projection guidance (GO:1902284)2.74194252
124neuromuscular synaptic transmission (GO:0007274)2.71554655
125behavioral response to ethanol (GO:0048149)2.61364240
126dendrite development (GO:0016358)2.59708558
127synaptic transmission, cholinergic (GO:0007271)2.59106171
128regulation of growth hormone secretion (GO:0060123)2.58719456
129regulation of axon guidance (GO:1902667)2.56407771
130neuronal stem cell maintenance (GO:0097150)2.56232949
131negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54275415
132dendrite morphogenesis (GO:0048813)2.50517852
133cilium morphogenesis (GO:0060271)2.50439108
134regulation of collateral sprouting (GO:0048670)2.49855202
135protein polyglutamylation (GO:0018095)2.49644850
136cell migration in hindbrain (GO:0021535)2.48615851
137somite development (GO:0061053)2.48072743
138regulation of non-canonical Wnt signaling pathway (GO:2000050)2.47590526
139regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.46534991
140cilium assembly (GO:0042384)2.46352437
141appendage development (GO:0048736)2.45979570
142limb development (GO:0060173)2.45979570
143cilium organization (GO:0044782)2.45288634
144otic vesicle formation (GO:0030916)2.43264283
145regulation of development, heterochronic (GO:0040034)2.41233280
146establishment of mitochondrion localization (GO:0051654)2.40946629
147adult walking behavior (GO:0007628)2.40340681
148regulation of timing of cell differentiation (GO:0048505)2.38184661
149negative regulation of axon extension involved in axon guidance (GO:0048843)2.37643042
150cilium movement (GO:0003341)2.33906535
151smoothened signaling pathway (GO:0007224)2.33042473
152synapse organization (GO:0050808)2.32200562
153positive regulation of growth hormone secretion (GO:0060124)2.30853283
154paraxial mesoderm development (GO:0048339)2.29335855
155forebrain neuron differentiation (GO:0021879)2.29151703
156neuron migration (GO:0001764)2.28403090
157hindbrain development (GO:0030902)2.28090511
158dorsal/ventral axis specification (GO:0009950)2.27962777
159sympathetic nervous system development (GO:0048485)2.27745175
160kidney morphogenesis (GO:0060993)2.27039470
161embryonic retina morphogenesis in camera-type eye (GO:0060059)2.26263398
162establishment of nucleus localization (GO:0040023)2.25502059
163DNA double-strand break processing (GO:0000729)2.25213327
164negative regulation of axon extension (GO:0030517)2.25007016
165negative regulation of DNA recombination (GO:0045910)2.23577053
166cerebral cortex cell migration (GO:0021795)2.23383431
167neuronal ion channel clustering (GO:0045161)2.23367164
168homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.22685839
169regulation of sarcomere organization (GO:0060297)2.21389937
170regulation of cilium movement (GO:0003352)2.21290540
171negative regulation of transcription regulatory region DNA binding (GO:2000678)2.21099277
172neuron fate determination (GO:0048664)2.20999938
173positive regulation of gastrulation (GO:2000543)2.20792204
174cell proliferation in forebrain (GO:0021846)2.19746325

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.84055640
2GBX2_23144817_ChIP-Seq_PC3_Human4.75151797
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.14948260
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04427313
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93014089
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89964130
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79881912
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63756458
9* TAF15_26573619_Chip-Seq_HEK293_Human2.58093179
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53052075
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.50741978
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47322510
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47322510
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.46619050
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.38880843
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38804705
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34250082
18* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32668659
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32161814
20REST_21632747_ChIP-Seq_MESCs_Mouse2.29936941
21* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23392162
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22469651
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18368569
24* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11330675
25* EWS_26573619_Chip-Seq_HEK293_Human2.04385931
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01368252
27* SMAD4_21799915_ChIP-Seq_A2780_Human2.00039317
28* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95855556
29* P300_19829295_ChIP-Seq_ESCs_Human1.95152694
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.94453163
31AR_21572438_ChIP-Seq_LNCaP_Human1.92874059
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92255346
33DROSHA_22980978_ChIP-Seq_HELA_Human1.89357155
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89291779
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.88420643
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.87611905
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.86392570
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.81277388
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.78916200
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76599097
41* FUS_26573619_Chip-Seq_HEK293_Human1.74272927
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74206329
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72805653
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68649631
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67722119
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66155722
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62972593
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.62713020
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.61935150
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56547715
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54698162
52* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51018589
53* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48072262
54* IRF1_19129219_ChIP-ChIP_H3396_Human1.47889517
55* AR_25329375_ChIP-Seq_VCAP_Human1.47028934
56* CBX2_27304074_Chip-Seq_ESCs_Mouse1.45340026
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.44518478
58* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43490318
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41864817
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41065046
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34723729
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34179905
63STAT3_23295773_ChIP-Seq_U87_Human1.33815093
64RNF2_27304074_Chip-Seq_NSC_Mouse1.31545028
65* TCF4_23295773_ChIP-Seq_U87_Human1.30817002
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.28491465
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27930163
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27872665
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27767418
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26692898
71* ER_23166858_ChIP-Seq_MCF-7_Human1.26350496
72* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26209474
73VDR_22108803_ChIP-Seq_LS180_Human1.24904278
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23597178
75CBP_20019798_ChIP-Seq_JUKART_Human1.23597178
76* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22947208
77* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20123566
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19401774
79* NANOG_18555785_Chip-Seq_ESCs_Mouse1.18209571
80WT1_19549856_ChIP-ChIP_CCG9911_Human1.17572043
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17266732
82TP53_16413492_ChIP-PET_HCT116_Human1.17144926
83TBX3_20139965_ChIP-Seq_MESCs_Mouse1.17131000
84AHR_22903824_ChIP-Seq_MCF-7_Human1.17081741
85TBX3_20139965_ChIP-Seq_ESCs_Mouse1.16691859
86SOX2_16153702_ChIP-ChIP_HESCs_Human1.15384218
87* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15269329
88* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14780485
89RUNX2_22187159_ChIP-Seq_PCA_Human1.14471512
90JUN_21703547_ChIP-Seq_K562_Human1.14308153
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13185280
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.12822205
93TP53_18474530_ChIP-ChIP_U2OS_Human1.12291732
94* AR_19668381_ChIP-Seq_PC3_Human1.11041389
95TCF4_22108803_ChIP-Seq_LS180_Human1.10958730
96IGF1R_20145208_ChIP-Seq_DFB_Human1.10848416
97ZNF274_21170338_ChIP-Seq_K562_Hela1.10487140
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10419416
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10419416
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10101587
101* TAL1_26923725_Chip-Seq_HPCs_Mouse1.09452542
102LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08210534
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08034936
104CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07929587
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07196924
106* PRDM14_20953172_ChIP-Seq_ESCs_Human1.06602112
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.06597066
108BCAT_22108803_ChIP-Seq_LS180_Human1.05607888
109* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05037671
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04762852
111* RING1B_27294783_Chip-Seq_ESCs_Mouse1.04338288
112* EZH2_27294783_Chip-Seq_NPCs_Mouse1.04062203
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03325490
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02940443
115KDM2B_26808549_Chip-Seq_REH_Human1.02814420
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02649079
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02487979
118* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01608533
119* E2F1_18555785_Chip-Seq_ESCs_Mouse1.01213299
120* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01147590
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00820014
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00726213
123* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99957651
124* SOX9_26525672_Chip-Seq_HEART_Mouse0.97983215
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97027803
126PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96885435
127* P53_22387025_ChIP-Seq_ESCs_Mouse0.96804973
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95823604
129BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94911539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.77773734
2MP0003880_abnormal_central_pattern5.31083716
3MP0003635_abnormal_synaptic_transmissio4.06532896
4MP0009745_abnormal_behavioral_response3.68169991
5MP0002063_abnormal_learning/memory/cond3.37947397
6MP0002064_seizures3.35254193
7MP0009046_muscle_twitch3.27493435
8MP0001968_abnormal_touch/_nociception3.27046488
9MP0004270_analgesia3.16374903
10MP0002572_abnormal_emotion/affect_behav3.03366551
11MP0002736_abnormal_nociception_after2.89879718
12MP0002735_abnormal_chemical_nociception2.80784713
13MP0001501_abnormal_sleep_pattern2.71819298
14MP0002272_abnormal_nervous_system2.68474714
15MP0002734_abnormal_mechanical_nocicepti2.47127206
16MP0001486_abnormal_startle_reflex2.44877727
17MP0002638_abnormal_pupillary_reflex2.43537346
18MP0009780_abnormal_chondrocyte_physiolo2.40810953
19MP0003787_abnormal_imprinting2.28517778
20MP0006292_abnormal_olfactory_placode2.22713498
21MP0002822_catalepsy2.22534728
22MP0002067_abnormal_sensory_capabilities2.17809068
23MP0005646_abnormal_pituitary_gland2.10688401
24MP0001440_abnormal_grooming_behavior2.10110656
25MP0005423_abnormal_somatic_nervous2.06912182
26MP0003890_abnormal_embryonic-extraembry2.04546306
27MP0003879_abnormal_hair_cell1.94402240
28MP0006072_abnormal_retinal_apoptosis1.93742993
29MP0001188_hyperpigmentation1.87019150
30MP0002557_abnormal_social/conspecific_i1.80486001
31MP0010030_abnormal_orbit_morphology1.79378072
32MP0003122_maternal_imprinting1.77106338
33MP0001970_abnormal_pain_threshold1.76955248
34MP0002938_white_spotting1.75506501
35MP0005499_abnormal_olfactory_system1.72592970
36MP0005394_taste/olfaction_phenotype1.72592970
37MP0002184_abnormal_innervation1.70535693
38MP0002751_abnormal_autonomic_nervous1.70233743
39MP0002733_abnormal_thermal_nociception1.70000552
40MP0006276_abnormal_autonomic_nervous1.67599667
41MP0005386_behavior/neurological_phenoty1.64718930
42MP0004924_abnormal_behavior1.64718930
43MP0004133_heterotaxia1.64395566
44MP0000778_abnormal_nervous_system1.60445846
45MP0008789_abnormal_olfactory_epithelium1.58222730
46MP0003937_abnormal_limbs/digits/tail_de1.58087732
47MP0005253_abnormal_eye_physiology1.55788401
48MP0002233_abnormal_nose_morphology1.55048751
49MP0003136_yellow_coat_color1.53521901
50MP0002653_abnormal_ependyma_morphology1.53495103
51MP0008569_lethality_at_weaning1.53086346
52MP0001293_anophthalmia1.52646517
53MP0001984_abnormal_olfaction1.49626377
54MP0002837_dystrophic_cardiac_calcinosis1.49531105
55MP0005187_abnormal_penis_morphology1.48051404
56MP0000566_synostosis1.47249220
57MP0002876_abnormal_thyroid_physiology1.45043010
58MP0002102_abnormal_ear_morphology1.42998363
59MP0000049_abnormal_middle_ear1.42439419
60MP0004142_abnormal_muscle_tone1.40837255
61MP0003119_abnormal_digestive_system1.37498486
62MP0000751_myopathy1.37257245
63MP0004811_abnormal_neuron_physiology1.35926210
64MP0005645_abnormal_hypothalamus_physiol1.33806738
65MP0002066_abnormal_motor_capabilities/c1.32902774
66MP0001529_abnormal_vocalization1.32485621
67MP0001299_abnormal_eye_distance/1.31924009
68MP0002697_abnormal_eye_size1.28414160
69MP0005171_absent_coat_pigmentation1.27625552
70MP0002234_abnormal_pharynx_morphology1.26251681
71MP0004858_abnormal_nervous_system1.25553320
72MP0003633_abnormal_nervous_system1.24622567
73MP0003861_abnormal_nervous_system1.22727391
74MP0000955_abnormal_spinal_cord1.18828419
75MP0002882_abnormal_neuron_morphology1.18731469
76MP0003329_amyloid_beta_deposits1.17344034
77MP0005391_vision/eye_phenotype1.17218290
78MP0001286_abnormal_eye_development1.16570648
79MP0003567_abnormal_fetal_cardiomyocyte1.15303401
80MP0004085_abnormal_heartbeat1.09733047
81MP0003631_nervous_system_phenotype1.08146484
82MP0005195_abnormal_posterior_eye1.07031230
83MP0003755_abnormal_palate_morphology1.05032781
84MP0002909_abnormal_adrenal_gland1.03779824
85MP0004885_abnormal_endolymph1.03522485
86MP0010386_abnormal_urinary_bladder1.03361760
87MP0001905_abnormal_dopamine_level1.03098513
88MP0005248_abnormal_Harderian_gland1.03058523
89MP0003123_paternal_imprinting1.00952775
90MP0001502_abnormal_circadian_rhythm1.00108229
91MP0003646_muscle_fatigue0.99719873
92MP0008874_decreased_physiological_sensi0.98849027
93MP0003942_abnormal_urinary_system0.98708574
94MP0001963_abnormal_hearing_physiology0.94607777
95MP0004484_altered_response_of0.94282169
96MP0000013_abnormal_adipose_tissue0.93544291
97MP0004145_abnormal_muscle_electrophysio0.92525675
98MP0004215_abnormal_myocardial_fiber0.91193892
99MP0002152_abnormal_brain_morphology0.90820312
100MP0004742_abnormal_vestibular_system0.89532869
101MP0000647_abnormal_sebaceous_gland0.89140248
102MP0002928_abnormal_bile_duct0.87435628
103MP0005503_abnormal_tendon_morphology0.86632253
104MP0003935_abnormal_craniofacial_develop0.85693410
105MP0002282_abnormal_trachea_morphology0.85096836
106MP0002069_abnormal_eating/drinking_beha0.82724990
107MP0001324_abnormal_eye_pigmentation0.82530600
108MP0000534_abnormal_ureter_morphology0.82227738
109MP0003283_abnormal_digestive_organ0.82018537
110MP0003121_genomic_imprinting0.80567551
111MP0009703_decreased_birth_body0.78968006
112MP0000516_abnormal_urinary_system0.78159332
113MP0005367_renal/urinary_system_phenotyp0.78159332
114MP0003385_abnormal_body_wall0.77413010
115MP0002081_perinatal_lethality0.77254633
116MP0008872_abnormal_physiological_respon0.77208266
117MP0001177_atelectasis0.76529743
118MP0009250_abnormal_appendicular_skeleto0.76431450
119MP0005551_abnormal_eye_electrophysiolog0.73465930
120MP0000569_abnormal_digit_pigmentation0.73347690
121MP0008877_abnormal_DNA_methylation0.73210961
122MP0002108_abnormal_muscle_morphology0.72272398
123MP0001664_abnormal_digestion0.71576828
124MP0003632_abnormal_nervous_system0.71499441
125MP0002229_neurodegeneration0.69998258
126MP0000631_abnormal_neuroendocrine_gland0.66807539
127MP0004233_abnormal_muscle_weight0.65396041
128MP0002752_abnormal_somatic_nervous0.64445824
129MP0005535_abnormal_body_temperature0.63896061
130MP0005623_abnormal_meninges_morphology0.63654025
131MP0000026_abnormal_inner_ear0.62045842
132MP0001943_abnormal_respiration0.59153535
133MP0005620_abnormal_muscle_contractility0.54919139
134MP0008004_abnormal_stomach_pH0.54448926
135MP0003183_abnormal_peptide_metabolism0.52082909
136MP0003075_altered_response_to0.51672292
137MP0010770_preweaning_lethality0.51360781
138MP0002082_postnatal_lethality0.51360781
139MP0003634_abnormal_glial_cell0.50591152
140MP0001485_abnormal_pinna_reflex0.49830669
141MP0003137_abnormal_impulse_conducting0.49584297
142MP0003938_abnormal_ear_development0.48718821
143MP0010769_abnormal_survival0.46481114
144MP0003690_abnormal_glial_cell0.45918259
145MP0004510_myositis0.45288658
146MP0004043_abnormal_pH_regulation0.44887369

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.60587441
2Hyperventilation (HP:0002883)7.06901057
3Epileptic encephalopathy (HP:0200134)6.74964573
4Atonic seizures (HP:0010819)6.43898161
5Focal seizures (HP:0007359)6.12304209
6Febrile seizures (HP:0002373)5.72131121
7Absence seizures (HP:0002121)5.01933322
8Dialeptic seizures (HP:0011146)4.67869329
9Myokymia (HP:0002411)4.64246499
10Broad-based gait (HP:0002136)4.54140187
11Generalized tonic-clonic seizures (HP:0002069)4.21671363
12Visual hallucinations (HP:0002367)3.74929004
13Gaze-evoked nystagmus (HP:0000640)3.58732752
14Protruding tongue (HP:0010808)3.58590025
15Excessive salivation (HP:0003781)3.58542391
16Drooling (HP:0002307)3.58542391
17Progressive cerebellar ataxia (HP:0002073)3.52493065
18True hermaphroditism (HP:0010459)3.46537577
19Absent speech (HP:0001344)3.38070881
20Pancreatic fibrosis (HP:0100732)3.34280278
21Poor eye contact (HP:0000817)3.29704393
22Amblyopia (HP:0000646)3.16893155
23Inability to walk (HP:0002540)3.13985852
24Abnormal social behavior (HP:0012433)3.13165943
25Impaired social interactions (HP:0000735)3.13165943
26Epileptiform EEG discharges (HP:0011182)3.11057586
27Blue irides (HP:0000635)3.08765138
28Septo-optic dysplasia (HP:0100842)3.05098148
29Impaired vibration sensation in the lower limbs (HP:0002166)3.03929462
30Fair hair (HP:0002286)2.98203943
31Pancreatic cysts (HP:0001737)2.95564078
32Hepatoblastoma (HP:0002884)2.95443812
33Intestinal atresia (HP:0011100)2.93941404
34Progressive inability to walk (HP:0002505)2.92660869
35Nephronophthisis (HP:0000090)2.82211789
36Colon cancer (HP:0003003)2.77968307
37Genital tract atresia (HP:0001827)2.75614315
38EEG with generalized epileptiform discharges (HP:0011198)2.73235112
39Vaginal atresia (HP:0000148)2.72810517
40Truncal ataxia (HP:0002078)2.70891878
41Cortical dysplasia (HP:0002539)2.66539226
42Dysdiadochokinesis (HP:0002075)2.64200379
43Generalized hypopigmentation of hair (HP:0011358)2.63600339
44Bifid tongue (HP:0010297)2.62949074
45Abnormal hair whorl (HP:0010721)2.62674272
46Molar tooth sign on MRI (HP:0002419)2.58164484
47Abnormality of midbrain morphology (HP:0002418)2.58164484
48Dysmetric saccades (HP:0000641)2.58065270
49Optic nerve hypoplasia (HP:0000609)2.57453735
50Abnormal eating behavior (HP:0100738)2.54005437
51Urinary bladder sphincter dysfunction (HP:0002839)2.53957405
52Hypsarrhythmia (HP:0002521)2.51246680
53Status epilepticus (HP:0002133)2.43419179
54Chronic hepatic failure (HP:0100626)2.40412750
55Oligodactyly (hands) (HP:0001180)2.39721329
56Narrow nasal bridge (HP:0000446)2.39336992
57Abnormality of salivation (HP:0100755)2.38882063
58Abnormality of the renal medulla (HP:0100957)2.37921826
59Thickened helices (HP:0000391)2.37556829
60Polyphagia (HP:0002591)2.36937979
61Anencephaly (HP:0002323)2.36779886
62Pheochromocytoma (HP:0002666)2.36448420
63Aplasia/Hypoplasia of the tongue (HP:0010295)2.35995993
64Cutaneous finger syndactyly (HP:0010554)2.34886626
65Action tremor (HP:0002345)2.33650002
66Hyperthyroidism (HP:0000836)2.30635612
67Postaxial hand polydactyly (HP:0001162)2.29285056
68Impaired smooth pursuit (HP:0007772)2.26490853
69Limb dystonia (HP:0002451)2.25452413
70Postaxial foot polydactyly (HP:0001830)2.25057482
71Fetal akinesia sequence (HP:0001989)2.24847759
72Depression (HP:0000716)2.24260178
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.24179602
74Anxiety (HP:0000739)2.23633076
75Cystic liver disease (HP:0006706)2.23286934
76Anophthalmia (HP:0000528)2.22636814
77Termporal pattern (HP:0011008)2.21935789
78Insidious onset (HP:0003587)2.21935789
79Impaired vibratory sensation (HP:0002495)2.21854254
80Dysmetria (HP:0001310)2.21574509
81Sclerocornea (HP:0000647)2.21022894
82Renal hypoplasia (HP:0000089)2.19473067
83Gait imbalance (HP:0002141)2.18643362
84Postural instability (HP:0002172)2.18426719
85Scanning speech (HP:0002168)2.15156289
86Neuroendocrine neoplasm (HP:0100634)2.14914325
87Generalized myoclonic seizures (HP:0002123)2.13727115
88Supernumerary spleens (HP:0009799)2.13468602
89Poor coordination (HP:0002370)2.11993550
90Occipital encephalocele (HP:0002085)2.11551061
91Abnormality of the corticospinal tract (HP:0002492)2.10379656
92Preaxial foot polydactyly (HP:0001841)2.09584078
93Tubulointerstitial nephritis (HP:0001970)2.09313999
94Growth hormone deficiency (HP:0000824)2.08272158
95Gastrointestinal atresia (HP:0002589)2.05652955
96Cutaneous syndactyly (HP:0012725)2.04718925
97Broad foot (HP:0001769)2.02912245
98Sensory axonal neuropathy (HP:0003390)2.02334886
99Abnormal lung lobation (HP:0002101)2.01761863
100Stereotypic behavior (HP:0000733)1.99935927
101Diplopia (HP:0000651)1.99426318
102Abnormality of binocular vision (HP:0011514)1.99426318
103Narrow forehead (HP:0000341)1.98018819
104Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97990083
105Short 4th metacarpal (HP:0010044)1.97990083
106Genetic anticipation (HP:0003743)1.97015835
107Gait ataxia (HP:0002066)1.96860188
108Oligomenorrhea (HP:0000876)1.96098451
109Bradykinesia (HP:0002067)1.95925717
110Vitreoretinal degeneration (HP:0000655)1.95431119
111Volvulus (HP:0002580)1.95189538
112Ankle clonus (HP:0011448)1.94751316
113Preaxial hand polydactyly (HP:0001177)1.94329940
114Medial flaring of the eyebrow (HP:0010747)1.93445901
115Lissencephaly (HP:0001339)1.93291844
116Widely spaced teeth (HP:0000687)1.92758677
117Urinary urgency (HP:0000012)1.92397587
118Hyperglycinemia (HP:0002154)1.91859261
119Micropenis (HP:0000054)1.91633841
120Congenital primary aphakia (HP:0007707)1.91611568
121Abnormality of the labia minora (HP:0012880)1.91478394
122Esophageal atresia (HP:0002032)1.91098863
123Exotropia (HP:0000577)1.90086816
124Torticollis (HP:0000473)1.89610192
125Labial hypoplasia (HP:0000066)1.89532949
126Gastroesophageal reflux (HP:0002020)1.89241615
127Oligodactyly (HP:0012165)1.88382064
128Incomplete penetrance (HP:0003829)1.88132897
129Clumsiness (HP:0002312)1.87861327
130Abnormality of ocular smooth pursuit (HP:0000617)1.86303831
131Aqueductal stenosis (HP:0002410)1.85985609
132Specific learning disability (HP:0001328)1.85759845
133Absent septum pellucidum (HP:0001331)1.85681506
134Abnormality of the lower motor neuron (HP:0002366)1.85355427
135Hypoventilation (HP:0002791)1.84568715
136Hemiparesis (HP:0001269)1.83919240
137Aplasia/Hypoplasia of the uvula (HP:0010293)1.82831733
138Focal dystonia (HP:0004373)1.82754481
139Resting tremor (HP:0002322)1.82514458
140Tubulointerstitial abnormality (HP:0001969)1.81885900
141Nephrogenic diabetes insipidus (HP:0009806)1.80767023
142Aplasia/Hypoplasia of the tibia (HP:0005772)1.80386802
143Degeneration of the lateral corticospinal tracts (HP:0002314)1.79329484
144Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79329484
145Spastic gait (HP:0002064)1.77935830
146Rib fusion (HP:0000902)1.75812020
147Abnormality of the 4th metacarpal (HP:0010012)1.75683903
148Dandy-Walker malformation (HP:0001305)1.75559734
149Abnormality of the ischium (HP:0003174)1.75559561
150Poor suck (HP:0002033)1.74585928
151Esotropia (HP:0000565)1.74163190
152Inappropriate behavior (HP:0000719)1.73505671
153Dynein arm defect of respiratory motile cilia (HP:0012255)1.73323531
154Absent/shortened dynein arms (HP:0200106)1.73323531
155Abnormality of the pubic bones (HP:0003172)1.72162571
156Supranuclear gaze palsy (HP:0000605)1.71317989
157Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71113907
158Hypoplastic female external genitalia (HP:0012815)1.70668938
159Congenital hepatic fibrosis (HP:0002612)1.69787237
160Hypoplastic ischia (HP:0003175)1.68692455
161Failure to thrive in infancy (HP:0001531)1.68259845
162Open mouth (HP:0000194)1.67579567
163Aplasia/Hypoplasia of the sternum (HP:0006714)1.67523348
164Intellectual disability, severe (HP:0010864)1.67415743
165Dyskinesia (HP:0100660)1.67330364
166Decreased testicular size (HP:0008734)1.67233400
167Mutism (HP:0002300)1.65277937
168Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65057481
169Abnormality of the septum pellucidum (HP:0007375)1.63807688
170Midline defect of the nose (HP:0004122)1.63749078
171Pachygyria (HP:0001302)1.61838929
172Cupped ear (HP:0000378)1.60632622
173Short tibia (HP:0005736)1.60566776
174Neoplasm of the oral cavity (HP:0100649)1.59982593
175Meckel diverticulum (HP:0002245)1.58519657
176Abnormality of the astrocytes (HP:0100707)1.58463444
177Astrocytoma (HP:0009592)1.58463444
178Abnormal biliary tract physiology (HP:0012439)1.58191467
179Bile duct proliferation (HP:0001408)1.58191467
180Abnormality of the ileum (HP:0001549)1.58154312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.45546081
2NTRK34.40099929
3EPHA44.05204526
4MAP3K43.29340946
5MAP2K73.24455077
6MAP3K123.12339404
7DAPK22.68394963
8AKT32.65373213
9CDK192.26731542
10MAP2K42.22161708
11MAP4K22.22130411
12MAP3K92.15973803
13PRPF4B2.12510754
14DAPK12.10929432
15PLK22.02687027
16CCNB12.02110165
17DYRK21.96811055
18BMPR1B1.88798633
19RIPK41.88515285
20MARK11.87959988
21MINK11.69312424
22MKNK21.67901049
23DYRK31.66700796
24EPHB21.62893722
25FGFR21.60320762
26MKNK11.52659584
27MAPK131.47683655
28TRIM281.46274117
29NTRK21.41296538
30ZAK1.40942917
31OXSR11.36413937
32CSNK1G11.31437275
33PLK41.28190796
34EPHA31.27849153
35PAK61.26144478
36TIE11.24404033
37NUAK11.23083666
38GRK51.21243848
39BMPR21.20050154
40TNIK1.19724655
41CSNK1G31.18502710
42SGK21.18375728
43PRKCG1.16613109
44CDC71.10483858
45SIK21.09512832
46CDK51.09491177
47CAMK2A1.08576469
48MUSK1.07629852
49SIK31.06813294
50STK38L1.06458578
51KSR11.06256228
52SGK2231.00786476
53SGK4941.00786476
54CAMKK20.98093009
55PTK2B0.94392108
56PLK30.90736446
57NTRK10.90617557
58CAMKK10.89964566
59CAMK2B0.89329365
60BRAF0.89018201
61VRK10.88261576
62KSR20.87636463
63TSSK60.85866455
64PNCK0.85799533
65PRKCE0.84974840
66ARAF0.84096314
67SGK30.83524087
68CSNK1A1L0.82862478
69PDK30.82643635
70PDK40.82643635
71NME10.81899318
72ERBB40.80289436
73FES0.79873109
74BCKDK0.77385755
75SRPK10.77051973
76MAP3K60.75880084
77FER0.74739714
78STK380.74305089
79TAF10.73915810
80BUB10.73502951
81MAPK150.72757999
82STK390.72592089
83NLK0.70240429
84TGFBR10.69727771
85GRK10.67875032
86PRKD30.67498980
87WEE10.67308186
88ACVR1B0.67041969
89ADRBK20.66821007
90CAMK10.66560578
91DYRK1B0.64606947
92MAP3K130.63952141
93SGK10.61967052
94INSRR0.61313861
95BRSK20.59866449
96STK160.57074516
97STK110.56454850
98GRK70.55748550
99FGFR10.55426020
100PKN10.54670545
101CAMK1G0.54335432
102CDK180.54016330
103PDK20.53927085
104RPS6KA40.53435328
105DAPK30.53094362
106MAP3K100.50441636
107LATS20.50392992
108PRKCH0.49512894
109WNK30.49363600
110CSNK1E0.49131846
111NEK10.49064306
112PLK10.49049872
113RAF10.48664812
114CDK150.48439141
115CSNK1A10.48205293
116CDK30.48054854
117TTK0.47951361
118ERBB20.46827900
119PASK0.46582953
120FRK0.46571772
121FGR0.46478646
122CDK140.46436892
123CAMK2D0.45682955
124MAPK70.45355179
125TYRO30.45042246
126PRKG10.45020080
127CAMK2G0.44977066
128ADRBK10.44869252
129MAPK120.44800412
130NEK20.44317898
131MYLK0.43366333
132UHMK10.42591216
133DYRK1A0.42179681
134CSNK1D0.41827261
135MAP3K20.41711239
136BCR0.41095744
137PINK10.40993499
138ATM0.40814875
139LATS10.40626383
140STK30.40341231
141OBSCN0.40143621
142WNK40.38185897
143PRKACB0.38175021
144NEK60.37552503
145RPS6KA30.37399086
146ERBB30.36859567
147PAK30.36419635
148CAMK40.36325624
149CDK11A0.36319254
150PDK10.34727843
151TNK20.33976149
152MAP2K10.33769851
153PDPK10.33581752
154PHKG20.32450813
155PHKG10.32450813
156CSNK1G20.31779235
157PRKACA0.31741061

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.60967609
2Synaptic vesicle cycle_Homo sapiens_hsa047213.69845047
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.04051242
4Morphine addiction_Homo sapiens_hsa050322.75116814
5Circadian entrainment_Homo sapiens_hsa047132.73295339
6GABAergic synapse_Homo sapiens_hsa047272.72775321
7Long-term potentiation_Homo sapiens_hsa047202.68986294
8Collecting duct acid secretion_Homo sapiens_hsa049662.68011283
9Glutamatergic synapse_Homo sapiens_hsa047242.58733349
10Amphetamine addiction_Homo sapiens_hsa050312.48659894
11Olfactory transduction_Homo sapiens_hsa047402.45361414
12Steroid biosynthesis_Homo sapiens_hsa001002.37144743
13Salivary secretion_Homo sapiens_hsa049702.11361030
14Taste transduction_Homo sapiens_hsa047422.05791600
15Dopaminergic synapse_Homo sapiens_hsa047282.02897961
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88726067
17Insulin secretion_Homo sapiens_hsa049111.87940440
18Serotonergic synapse_Homo sapiens_hsa047261.82649249
19Long-term depression_Homo sapiens_hsa047301.80179052
20Calcium signaling pathway_Homo sapiens_hsa040201.78245114
21Propanoate metabolism_Homo sapiens_hsa006401.74412270
22Renin secretion_Homo sapiens_hsa049241.73049220
23Basal cell carcinoma_Homo sapiens_hsa052171.71447674
24Hedgehog signaling pathway_Homo sapiens_hsa043401.70236356
25Cholinergic synapse_Homo sapiens_hsa047251.65178705
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61687770
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61618332
28Gastric acid secretion_Homo sapiens_hsa049711.61313791
29Fanconi anemia pathway_Homo sapiens_hsa034601.60362542
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57831983
31Oxytocin signaling pathway_Homo sapiens_hsa049211.54260268
32Vibrio cholerae infection_Homo sapiens_hsa051101.51981481
33Protein export_Homo sapiens_hsa030601.51589233
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49687054
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48961536
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.45213858
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.42075560
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41811007
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36516797
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.32879865
41Cocaine addiction_Homo sapiens_hsa050301.30518560
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27226985
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22140167
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21490724
45GnRH signaling pathway_Homo sapiens_hsa049121.18277861
46cAMP signaling pathway_Homo sapiens_hsa040241.16921110
47Hippo signaling pathway_Homo sapiens_hsa043901.16446247
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14628471
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14122600
50Tryptophan metabolism_Homo sapiens_hsa003801.12441894
51Gap junction_Homo sapiens_hsa045401.09372861
52Linoleic acid metabolism_Homo sapiens_hsa005911.09267021
53Oxidative phosphorylation_Homo sapiens_hsa001901.06540189
54Axon guidance_Homo sapiens_hsa043601.06356361
55Type II diabetes mellitus_Homo sapiens_hsa049301.05891602
56Basal transcription factors_Homo sapiens_hsa030221.05788137
57Non-homologous end-joining_Homo sapiens_hsa034501.05297639
58Cardiac muscle contraction_Homo sapiens_hsa042601.01514362
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00320101
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97438568
61ErbB signaling pathway_Homo sapiens_hsa040120.95711164
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95516801
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.94275536
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93034364
65Estrogen signaling pathway_Homo sapiens_hsa049150.92471912
66Glioma_Homo sapiens_hsa052140.92385646
67Dilated cardiomyopathy_Homo sapiens_hsa054140.92341838
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89920695
69RNA degradation_Homo sapiens_hsa030180.86941693
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86711557
71Melanogenesis_Homo sapiens_hsa049160.85712484
72Mismatch repair_Homo sapiens_hsa034300.84664764
73Phototransduction_Homo sapiens_hsa047440.84113376
74Retinol metabolism_Homo sapiens_hsa008300.84083233
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.83993523
76Rheumatoid arthritis_Homo sapiens_hsa053230.83982098
77Nitrogen metabolism_Homo sapiens_hsa009100.83669990
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81725887
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81573971
80Homologous recombination_Homo sapiens_hsa034400.81403317
81Alzheimers disease_Homo sapiens_hsa050100.79897321
82TGF-beta signaling pathway_Homo sapiens_hsa043500.77606781
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76862758
84beta-Alanine metabolism_Homo sapiens_hsa004100.76715493
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.76608574
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75033445
87Fatty acid metabolism_Homo sapiens_hsa012120.73983172
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71563818
89Fatty acid degradation_Homo sapiens_hsa000710.71007379
90Lysine degradation_Homo sapiens_hsa003100.70962379
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69277266
92Type I diabetes mellitus_Homo sapiens_hsa049400.68369045
93MAPK signaling pathway_Homo sapiens_hsa040100.67982296
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66512705
95Peroxisome_Homo sapiens_hsa041460.66245356
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66086498
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65332085
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.63829863
99Pyruvate metabolism_Homo sapiens_hsa006200.63190188
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62172219
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61811792
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58377491
103Ras signaling pathway_Homo sapiens_hsa040140.58051066
104Tight junction_Homo sapiens_hsa045300.57445486
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57123541
106Pancreatic secretion_Homo sapiens_hsa049720.56437735
107Thyroid hormone synthesis_Homo sapiens_hsa049180.55490717
108Chemical carcinogenesis_Homo sapiens_hsa052040.54987590
109Oocyte meiosis_Homo sapiens_hsa041140.54616609
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54361897
111Fatty acid elongation_Homo sapiens_hsa000620.54256616
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53857687
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53655300
114Ovarian steroidogenesis_Homo sapiens_hsa049130.52922463
115Ether lipid metabolism_Homo sapiens_hsa005650.52349127
116Glucagon signaling pathway_Homo sapiens_hsa049220.51648827
117Selenocompound metabolism_Homo sapiens_hsa004500.51409114
118African trypanosomiasis_Homo sapiens_hsa051430.51258502
119Colorectal cancer_Homo sapiens_hsa052100.50197035
120Circadian rhythm_Homo sapiens_hsa047100.49147646
121Phagosome_Homo sapiens_hsa041450.49017057
122Caffeine metabolism_Homo sapiens_hsa002320.48236205
123Histidine metabolism_Homo sapiens_hsa003400.47615014
124Rap1 signaling pathway_Homo sapiens_hsa040150.47556615
125Vitamin B6 metabolism_Homo sapiens_hsa007500.46896736
126Arginine and proline metabolism_Homo sapiens_hsa003300.46528227
127Dorso-ventral axis formation_Homo sapiens_hsa043200.46241510
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45531882
129ABC transporters_Homo sapiens_hsa020100.44622654
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.44269479
131Parkinsons disease_Homo sapiens_hsa050120.43229241
132Choline metabolism in cancer_Homo sapiens_hsa052310.39542808
133Melanoma_Homo sapiens_hsa052180.39433640
134Prion diseases_Homo sapiens_hsa050200.39102766
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34472648
136Inositol phosphate metabolism_Homo sapiens_hsa005620.33748548
137Wnt signaling pathway_Homo sapiens_hsa043100.32561478
138Huntingtons disease_Homo sapiens_hsa050160.32071879
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31210696
140Butanoate metabolism_Homo sapiens_hsa006500.30833580
141Bile secretion_Homo sapiens_hsa049760.28619008
142Alcoholism_Homo sapiens_hsa050340.27488496
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26875132
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24596072
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.23618198
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21265395
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21095363
148Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20393785
149Insulin signaling pathway_Homo sapiens_hsa049100.19948605
150Arginine biosynthesis_Homo sapiens_hsa002200.19841634
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19219508
1522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.17388343
153Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15712784

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