KCNS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.20281186
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.02738078
3vocalization behavior (GO:0071625)5.99896832
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.71159054
5sodium ion export (GO:0071436)5.64139455
6synaptic vesicle exocytosis (GO:0016079)5.48492267
7locomotory exploration behavior (GO:0035641)5.44082279
8regulation of glutamate receptor signaling pathway (GO:1900449)5.26488184
9protein localization to synapse (GO:0035418)5.25059420
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.21072414
11ionotropic glutamate receptor signaling pathway (GO:0035235)5.16844811
12synaptic vesicle maturation (GO:0016188)5.16232799
13glutamate secretion (GO:0014047)4.95409599
14neuron cell-cell adhesion (GO:0007158)4.94880618
15regulation of synaptic vesicle exocytosis (GO:2000300)4.75707399
16regulation of long-term neuronal synaptic plasticity (GO:0048169)4.71470719
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.69364128
18glutamate receptor signaling pathway (GO:0007215)4.68746629
19regulation of neuronal synaptic plasticity (GO:0048168)4.57929670
20neuronal action potential propagation (GO:0019227)4.57702664
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.55762496
22exploration behavior (GO:0035640)4.54946104
23L-amino acid import (GO:0043092)4.50328947
24cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.49672573
25synaptic transmission, glutamatergic (GO:0035249)4.45160557
26neurotransmitter-gated ion channel clustering (GO:0072578)4.44821608
27neuron-neuron synaptic transmission (GO:0007270)4.42955799
28neurotransmitter secretion (GO:0007269)4.33210797
29dendritic spine morphogenesis (GO:0060997)4.26798804
30regulation of synapse structural plasticity (GO:0051823)4.24943797
31regulation of excitatory postsynaptic membrane potential (GO:0060079)4.24514063
32regulation of synaptic vesicle transport (GO:1902803)4.23738510
33layer formation in cerebral cortex (GO:0021819)4.22854994
34cerebellar granule cell differentiation (GO:0021707)4.12584483
35regulation of dendritic spine morphogenesis (GO:0061001)4.10133522
36long-term memory (GO:0007616)4.07344113
37positive regulation of membrane potential (GO:0045838)4.05639746
38negative regulation of dendrite morphogenesis (GO:0050774)4.04787005
39gamma-aminobutyric acid signaling pathway (GO:0007214)4.03069258
40regulation of postsynaptic membrane potential (GO:0060078)4.01516528
41amino acid import (GO:0043090)3.99105115
42cell communication by electrical coupling (GO:0010644)3.97343042
43regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.89780291
44neuron recognition (GO:0008038)3.85739084
45response to histamine (GO:0034776)3.83951769
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83611198
47gamma-aminobutyric acid transport (GO:0015812)3.82017973
48regulation of synaptic plasticity (GO:0048167)3.81277556
49positive regulation of synapse maturation (GO:0090129)3.79218067
50long-term synaptic potentiation (GO:0060291)3.75813369
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.75511428
52postsynaptic membrane organization (GO:0001941)3.68459891
53negative regulation of synaptic transmission, GABAergic (GO:0032229)3.66651220
54membrane depolarization during action potential (GO:0086010)3.65685303
55presynaptic membrane assembly (GO:0097105)3.64096914
56regulation of synaptic transmission, glutamatergic (GO:0051966)3.62920837
57behavioral defense response (GO:0002209)3.62721253
58behavioral fear response (GO:0001662)3.62721253
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.61930731
60regulation of glutamate secretion (GO:0014048)3.60751632
61transmission of nerve impulse (GO:0019226)3.58782680
62auditory behavior (GO:0031223)3.55417657
63neurotransmitter transport (GO:0006836)3.50819712
64regulation of dendritic spine development (GO:0060998)3.50498798
65G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.49033448
66cellular sodium ion homeostasis (GO:0006883)3.48298385
67regulation of female receptivity (GO:0045924)3.47064240
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46838137
69positive regulation of neurotransmitter secretion (GO:0001956)3.44782325
70proline transport (GO:0015824)3.43585798
71positive regulation of dendritic spine morphogenesis (GO:0061003)3.43578482
72neuromuscular process controlling balance (GO:0050885)3.43281727
73potassium ion homeostasis (GO:0055075)3.41479633
74G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.41068080
75fear response (GO:0042596)3.38601425
76presynaptic membrane organization (GO:0097090)3.38070423
77synaptic vesicle endocytosis (GO:0048488)3.37419935
78prepulse inhibition (GO:0060134)3.36299878
79positive regulation of dendritic spine development (GO:0060999)3.36222893
80axonal fasciculation (GO:0007413)3.36010583
81regulation of neurotransmitter secretion (GO:0046928)3.35404031
82activation of protein kinase A activity (GO:0034199)3.33862276
83behavioral response to cocaine (GO:0048148)3.33787921
84positive regulation of neurotransmitter transport (GO:0051590)3.32576856
85regulation of vesicle fusion (GO:0031338)3.32395239
86membrane depolarization (GO:0051899)3.31784074
87serotonin metabolic process (GO:0042428)3.31513772
88regulation of neurotransmitter levels (GO:0001505)3.30219523
89learning (GO:0007612)3.29695477
90response to auditory stimulus (GO:0010996)3.29331219
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.29206142
92membrane hyperpolarization (GO:0060081)3.28664049
93regulation of ARF protein signal transduction (GO:0032012)3.27284705
94cellular potassium ion homeostasis (GO:0030007)3.26119954
95dendritic spine organization (GO:0097061)3.25150486
96startle response (GO:0001964)3.21008260
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.18323152
98female mating behavior (GO:0060180)3.17956413
99mating behavior (GO:0007617)3.15440793
100positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11958825
101synapse assembly (GO:0007416)3.11909022
102regulation of neurotransmitter transport (GO:0051588)3.11724961
103cell communication involved in cardiac conduction (GO:0086065)3.11670249
104acidic amino acid transport (GO:0015800)3.09909464
105positive regulation of synaptic transmission (GO:0050806)3.09215082
106potassium ion import (GO:0010107)3.08447739
107vesicle transport along microtubule (GO:0047496)3.07933847
108* synaptic transmission (GO:0007268)3.07784881
109regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.07197047
110neuromuscular synaptic transmission (GO:0007274)3.06221861
111regulation of synaptic transmission (GO:0050804)3.06147988
112negative regulation of amino acid transport (GO:0051956)3.04527850
113cerebellar Purkinje cell differentiation (GO:0021702)3.04083710
114regulation of voltage-gated calcium channel activity (GO:1901385)3.03616934
115regulation of synapse maturation (GO:0090128)3.03230337
116social behavior (GO:0035176)3.02940145
117intraspecies interaction between organisms (GO:0051703)3.02940145
118striatum development (GO:0021756)3.02283839
119detection of calcium ion (GO:0005513)3.01004366
120synaptic transmission, dopaminergic (GO:0001963)3.00510784
121mechanosensory behavior (GO:0007638)2.99969307
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99652261
123neuronal ion channel clustering (GO:0045161)2.99368809
124neuromuscular process (GO:0050905)2.97355922
125retinal cone cell development (GO:0046549)2.94168917
126phosphorelay signal transduction system (GO:0000160)2.90880188
127cytoskeletal anchoring at plasma membrane (GO:0007016)2.90862113
128primary amino compound metabolic process (GO:1901160)2.86525996
129regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.84305326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.29186690
2GBX2_23144817_ChIP-Seq_PC3_Human3.78517552
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.27026677
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.22929412
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.21735285
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.77102682
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.75572442
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75572016
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75572016
10* RARB_27405468_Chip-Seq_BRAIN_Mouse2.71686689
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69655289
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.63109247
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57126230
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56519460
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56144483
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54239319
17DROSHA_22980978_ChIP-Seq_HELA_Human2.32969504
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32382739
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.31504202
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30112362
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26786917
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.24733754
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.20618137
24* REST_18959480_ChIP-ChIP_MESCs_Mouse2.18645676
25TAF15_26573619_Chip-Seq_HEK293_Human2.06290301
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00490753
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96366703
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90309561
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88208632
30* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81443902
31AR_21572438_ChIP-Seq_LNCaP_Human1.78375540
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75843920
33SMAD4_21799915_ChIP-Seq_A2780_Human1.73257639
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69385235
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67743586
36* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65679841
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65414230
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.53396638
39P300_19829295_ChIP-Seq_ESCs_Human1.52213072
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46418865
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42307601
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41780949
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.38989675
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35012316
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.34742332
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34536614
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.34175157
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33474824
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31002385
50* RING1B_27294783_Chip-Seq_ESCs_Mouse1.29676135
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29246014
52* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28566191
53* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28302659
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28223783
55ZNF274_21170338_ChIP-Seq_K562_Hela1.28161214
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.27682573
57* AR_25329375_ChIP-Seq_VCAP_Human1.27312694
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27294105
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.27175011
60CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26347012
61* STAT3_23295773_ChIP-Seq_U87_Human1.22133350
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21998073
63* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20771160
64* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19488263
65FUS_26573619_Chip-Seq_HEK293_Human1.17864859
66RNF2_27304074_Chip-Seq_NSC_Mouse1.17489721
67AR_19668381_ChIP-Seq_PC3_Human1.17130962
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16768715
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15214606
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13198112
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12000460
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11104023
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10214643
74TCF4_23295773_ChIP-Seq_U87_Human1.09912027
75* EP300_21415370_ChIP-Seq_HL-1_Mouse1.09674708
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.09385957
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.09017120
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08597447
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07140696
80WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06787970
81KDM2B_26808549_Chip-Seq_K562_Human1.06419102
82TET1_21490601_ChIP-Seq_MESCs_Mouse1.06327762
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.05070715
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04925364
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.03052866
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02775752
87VDR_22108803_ChIP-Seq_LS180_Human1.02717296
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02551221
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01763119
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01524223
91* RUNX2_22187159_ChIP-Seq_PCA_Human0.99809633
92* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99675775
93JUN_21703547_ChIP-Seq_K562_Human0.99255447
94* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98676061
95* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98268675
96AHR_22903824_ChIP-Seq_MCF-7_Human0.97713825
97ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97164905
98ER_23166858_ChIP-Seq_MCF-7_Human0.96893638
99TP53_16413492_ChIP-PET_HCT116_Human0.96708055
100NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96660283
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96660283
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95667792
103IGF1R_20145208_ChIP-Seq_DFB_Human0.95196811
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94493876
105* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93836499
106KDM2B_26808549_Chip-Seq_REH_Human0.91850424
107EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91808335
108TP53_18474530_ChIP-ChIP_U2OS_Human0.91620134
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.91074849
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90285197
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89993864
112ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89622773
113NANOG_18555785_Chip-Seq_ESCs_Mouse0.88687984
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87169984
115ESR2_21235772_ChIP-Seq_MCF-7_Human0.87031815
116BCAT_22108803_ChIP-Seq_LS180_Human0.86654461
117* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86047583
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85820889
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.84782503
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83995988
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.83593080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.62374050
2MP0003880_abnormal_central_pattern5.41095340
3MP0003635_abnormal_synaptic_transmissio4.34045615
4MP0009745_abnormal_behavioral_response3.71136054
5MP0004270_analgesia3.57507399
6MP0002063_abnormal_learning/memory/cond3.54831008
7MP0002822_catalepsy3.40349021
8MP0002064_seizures3.33428383
9MP0009046_muscle_twitch3.22698620
10MP0001968_abnormal_touch/_nociception3.14916487
11MP0002572_abnormal_emotion/affect_behav3.00384219
12MP0002272_abnormal_nervous_system2.72160041
13MP0001486_abnormal_startle_reflex2.68193034
14MP0005423_abnormal_somatic_nervous2.59022095
15MP0002736_abnormal_nociception_after2.55021928
16MP0002734_abnormal_mechanical_nocicepti2.50377140
17MP0001501_abnormal_sleep_pattern2.49594674
18MP0001440_abnormal_grooming_behavior2.21492142
19MP0002735_abnormal_chemical_nociception2.07754106
20MP0002067_abnormal_sensory_capabilities1.95101439
21MP0001970_abnormal_pain_threshold1.90177575
22MP0003329_amyloid_beta_deposits1.89449824
23MP0002733_abnormal_thermal_nociception1.87972225
24MP0009780_abnormal_chondrocyte_physiolo1.82972199
25MP0004924_abnormal_behavior1.81649316
26MP0005386_behavior/neurological_phenoty1.81649316
27MP0008438_abnormal_cutaneous_collagen1.80490722
28MP0002184_abnormal_innervation1.78501318
29MP0002557_abnormal_social/conspecific_i1.77255302
30MP0000778_abnormal_nervous_system1.76116820
31MP0008569_lethality_at_weaning1.75249426
32MP0003879_abnormal_hair_cell1.67600438
33MP0004811_abnormal_neuron_physiology1.66770835
34MP0006276_abnormal_autonomic_nervous1.64736572
35MP0001529_abnormal_vocalization1.63044110
36MP0005646_abnormal_pituitary_gland1.62393825
37MP0002909_abnormal_adrenal_gland1.61671795
38MP0001984_abnormal_olfaction1.48745435
39MP0000955_abnormal_spinal_cord1.46230668
40MP0002066_abnormal_motor_capabilities/c1.42114755
41MP0004142_abnormal_muscle_tone1.41685322
42MP0001958_emphysema1.40544557
43MP0001188_hyperpigmentation1.40421713
44MP0005503_abnormal_tendon_morphology1.38088920
45MP0002882_abnormal_neuron_morphology1.36381347
46MP0001905_abnormal_dopamine_level1.32346963
47MP0003633_abnormal_nervous_system1.31581031
48MP0004858_abnormal_nervous_system1.30686422
49MP0005645_abnormal_hypothalamus_physiol1.26992988
50MP0001502_abnormal_circadian_rhythm1.26181400
51MP0003787_abnormal_imprinting1.24965834
52MP0004885_abnormal_endolymph1.23442947
53MP0005409_darkened_coat_color1.14035500
54MP0001348_abnormal_lacrimal_gland1.11517781
55MP0003631_nervous_system_phenotype1.11480330
56MP0002152_abnormal_brain_morphology1.06561048
57MP0003122_maternal_imprinting1.05094045
58MP0002837_dystrophic_cardiac_calcinosis1.02693717
59MP0008874_decreased_physiological_sensi1.02385942
60MP0010386_abnormal_urinary_bladder1.01926546
61MP0001299_abnormal_eye_distance/1.00518374
62MP0008872_abnormal_physiological_respon0.98867696
63MP0000751_myopathy0.97771008
64MP0000013_abnormal_adipose_tissue0.94683681
65MP0002229_neurodegeneration0.93356487
66MP0005551_abnormal_eye_electrophysiolog0.92805267
67MP0002069_abnormal_eating/drinking_beha0.92801504
68MP0005275_abnormal_skin_tensile0.92252924
69MP0004742_abnormal_vestibular_system0.90659134
70MP0004145_abnormal_muscle_electrophysio0.90546949
71MP0004085_abnormal_heartbeat0.89579105
72MP0003075_altered_response_to0.86379128
73MP0000604_amyloidosis0.86328521
74MP0001177_atelectasis0.85638231
75MP0003690_abnormal_glial_cell0.85041803
76MP0005535_abnormal_body_temperature0.84336572
77MP0001963_abnormal_hearing_physiology0.82888399
78MP0002295_abnormal_pulmonary_circulatio0.82819080
79MP0003705_abnormal_hypodermis_morpholog0.82778979
80MP0003634_abnormal_glial_cell0.80253129
81MP0000920_abnormal_myelination0.79455150
82MP0004484_altered_response_of0.77926432
83MP0001346_abnormal_lacrimal_gland0.76189944
84MP0008961_abnormal_basal_metabolism0.76096422
85MP0003632_abnormal_nervous_system0.75985018
86MP0005499_abnormal_olfactory_system0.75155252
87MP0005394_taste/olfaction_phenotype0.75155252
88MP0000534_abnormal_ureter_morphology0.75017234
89MP0004215_abnormal_myocardial_fiber0.73276964
90MP0002090_abnormal_vision0.72199128
91MP0002752_abnormal_somatic_nervous0.71954028
92MP0005623_abnormal_meninges_morphology0.71838010
93MP0000631_abnormal_neuroendocrine_gland0.69263072
94MP0002638_abnormal_pupillary_reflex0.67225409
95MP0002876_abnormal_thyroid_physiology0.66406772
96MP0001485_abnormal_pinna_reflex0.65036239
97MP0003279_aneurysm0.64763283
98MP0003123_paternal_imprinting0.63126246
99MP0003045_fibrosis0.61824755
100MP0005167_abnormal_blood-brain_barrier0.61371570
101MP0002133_abnormal_respiratory_system0.59280576
102MP0005388_respiratory_system_phenotype0.59280576
103MP0001664_abnormal_digestion0.58671253
104MP0004233_abnormal_muscle_weight0.56881379
105MP0005187_abnormal_penis_morphology0.56839507
106MP0004510_myositis0.56301314
107MP0003283_abnormal_digestive_organ0.56030907
108MP0000569_abnormal_digit_pigmentation0.55732541
109MP0001943_abnormal_respiration0.55560338
110MP0003137_abnormal_impulse_conducting0.55149619
111MP0004147_increased_porphyrin_level0.53292215
112MP0010768_mortality/aging0.52648883
113MP0010234_abnormal_vibrissa_follicle0.49246670
114MP0010769_abnormal_survival0.48772475
115MP0003861_abnormal_nervous_system0.48708963
116MP0003956_abnormal_body_size0.48406560
117MP0002082_postnatal_lethality0.48076898
118MP0010770_preweaning_lethality0.48076898
119MP0004130_abnormal_muscle_cell0.46835721

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.36799537
2Myokymia (HP:0002411)7.47912704
3Focal seizures (HP:0007359)6.13468661
4Visual hallucinations (HP:0002367)5.28120897
5Epileptic encephalopathy (HP:0200134)5.11754116
6Atonic seizures (HP:0010819)4.80090089
7Absence seizures (HP:0002121)4.41668888
8Febrile seizures (HP:0002373)4.37493998
9Hyperventilation (HP:0002883)4.20797498
10Progressive cerebellar ataxia (HP:0002073)4.19391541
11Generalized tonic-clonic seizures (HP:0002069)4.06664559
12Dialeptic seizures (HP:0011146)4.02221101
13Broad-based gait (HP:0002136)3.99807847
14Action tremor (HP:0002345)3.86379575
15Poor eye contact (HP:0000817)3.65038916
16Dysdiadochokinesis (HP:0002075)3.59512632
17Impaired vibration sensation in the lower limbs (HP:0002166)3.42447515
18Anxiety (HP:0000739)3.36339314
19Amblyopia (HP:0000646)3.35091294
20Gaze-evoked nystagmus (HP:0000640)3.31739924
21Impaired social interactions (HP:0000735)3.31553125
22Abnormal social behavior (HP:0012433)3.31553125
23Depression (HP:0000716)3.24747260
24Dysmetria (HP:0001310)3.24429902
25Supranuclear gaze palsy (HP:0000605)3.22984157
26Ankle clonus (HP:0011448)3.18563609
27Akinesia (HP:0002304)3.17215123
28Urinary bladder sphincter dysfunction (HP:0002839)3.16348253
29Obstructive sleep apnea (HP:0002870)3.08541373
30Truncal ataxia (HP:0002078)3.04779327
31Cerebral inclusion bodies (HP:0100314)2.98237968
32Abnormal eating behavior (HP:0100738)2.94425144
33Drooling (HP:0002307)2.91982081
34Excessive salivation (HP:0003781)2.91982081
35Postural instability (HP:0002172)2.89664219
36Progressive inability to walk (HP:0002505)2.88180212
37Mutism (HP:0002300)2.86520263
38Scanning speech (HP:0002168)2.84188446
39Papilledema (HP:0001085)2.78897030
40Torticollis (HP:0000473)2.74784176
41Urinary urgency (HP:0000012)2.73801122
42Neurofibrillary tangles (HP:0002185)2.72861212
43Insidious onset (HP:0003587)2.69917354
44Termporal pattern (HP:0011008)2.69917354
45Stereotypic behavior (HP:0000733)2.67677781
46Epileptiform EEG discharges (HP:0011182)2.64483113
47Spastic gait (HP:0002064)2.61088574
48Focal dystonia (HP:0004373)2.55144113
49Inability to walk (HP:0002540)2.54241925
50Impaired smooth pursuit (HP:0007772)2.50192995
51Abnormality of the lower motor neuron (HP:0002366)2.50052070
52EEG with generalized epileptiform discharges (HP:0011198)2.47330460
53Tetraplegia (HP:0002445)2.46511731
54Bradykinesia (HP:0002067)2.45840419
55Abnormality of the corticospinal tract (HP:0002492)2.45309967
56Protrusio acetabuli (HP:0003179)2.43450704
57Genetic anticipation (HP:0003743)2.37646431
58Intention tremor (HP:0002080)2.37250440
59Fetal akinesia sequence (HP:0001989)2.36599820
60Absent speech (HP:0001344)2.33084044
61Abnormality of binocular vision (HP:0011514)2.32548281
62Diplopia (HP:0000651)2.32548281
63Hypsarrhythmia (HP:0002521)2.30538331
64Annular pancreas (HP:0001734)2.30507383
65Hemiparesis (HP:0001269)2.30171385
66Impaired vibratory sensation (HP:0002495)2.29686429
67Rigidity (HP:0002063)2.28726842
68Craniofacial dystonia (HP:0012179)2.28402782
69Delusions (HP:0000746)2.25923399
70Generalized myoclonic seizures (HP:0002123)2.21390637
71Status epilepticus (HP:0002133)2.21276453
72Lower limb muscle weakness (HP:0007340)2.20302020
73Vascular tortuosity (HP:0004948)2.19962856
74Dysmetric saccades (HP:0000641)2.19038125
75Neuronal loss in central nervous system (HP:0002529)2.15910507
76Resting tremor (HP:0002322)2.14785784
77Morphological abnormality of the pyramidal tract (HP:0002062)2.12511676
78Abnormality of ocular smooth pursuit (HP:0000617)2.09987301
79Mild short stature (HP:0003502)2.08688058
80Premature rupture of membranes (HP:0001788)2.07535996
81Limb dystonia (HP:0002451)2.06676741
82Aortic aneurysm (HP:0004942)2.05225551
83Degeneration of the lateral corticospinal tracts (HP:0002314)2.04950630
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.04950630
85Hemiplegia (HP:0002301)2.02605032
86Lower limb amyotrophy (HP:0007210)2.02560588
87Incomplete penetrance (HP:0003829)2.01905359
88Blue irides (HP:0000635)2.00468591
89Ankyloglossia (HP:0010296)1.98779874
90Protruding tongue (HP:0010808)1.97309697
91Insomnia (HP:0100785)1.97216790
92Lower limb asymmetry (HP:0100559)1.97150172
93Abnormality of salivation (HP:0100755)1.97034143
94Polyphagia (HP:0002591)1.95071687
95Pheochromocytoma (HP:0002666)1.93978564
96Apathy (HP:0000741)1.93370839
97Amyotrophic lateral sclerosis (HP:0007354)1.93003903
98Megalencephaly (HP:0001355)1.92852360
99Diminished movement (HP:0002374)1.91123092
100Gait ataxia (HP:0002066)1.90067063
101Overgrowth (HP:0001548)1.89350416
102Psychosis (HP:0000709)1.88380412
103Sleep apnea (HP:0010535)1.88176890
104Arterial tortuosity (HP:0005116)1.86121872
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84294826
106Inappropriate behavior (HP:0000719)1.84283243
107Pointed chin (HP:0000307)1.84110642
108Ventricular fibrillation (HP:0001663)1.83552247
109Abnormal EKG (HP:0003115)1.82329294
110Neonatal short-limb short stature (HP:0008921)1.81914720
111Gait imbalance (HP:0002141)1.81658400
112Hyperthyroidism (HP:0000836)1.81433584
113Agitation (HP:0000713)1.79614870
114Abnormality of saccadic eye movements (HP:0000570)1.77102339
115Bradycardia (HP:0001662)1.76743826
116Rapidly progressive (HP:0003678)1.76721077
117Hypoventilation (HP:0002791)1.74838094
118Specific learning disability (HP:0001328)1.72976375
119Clonus (HP:0002169)1.72280067
120Atrophic scars (HP:0001075)1.70561504
121Aplasia involving bones of the upper limbs (HP:0009823)1.69905669
122Aplasia of the phalanges of the hand (HP:0009802)1.69905669
123Aplasia involving bones of the extremities (HP:0009825)1.69905669
124Bowel diverticulosis (HP:0005222)1.69356247
125Diminished motivation (HP:0000745)1.68007109
126Turricephaly (HP:0000262)1.66626159
127Wormian bones (HP:0002645)1.66033897

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.45388469
2NTRK34.47832390
3MAP3K93.56241273
4MAP3K42.89691451
5CASK2.78786975
6MARK12.78538195
7RIPK42.71077584
8MINK12.65315161
9DAPK22.55226910
10MAP2K72.43241159
11MAP3K122.09957539
12KSR21.98599199
13NTRK21.96987550
14PAK61.94202609
15DAPK11.89115570
16NTRK11.83906360
17MAP2K41.76060103
18KSR11.75382987
19PRKD31.72202033
20SIK21.68263753
21PLK21.66097068
22CAMKK11.62318726
23CDK51.55093175
24TNIK1.50921580
25FES1.50615482
26ARAF1.44007540
27PRPF4B1.42330297
28GRK51.38430057
29CDK191.26494190
30MAP3K131.25994673
31PRKCG1.20201523
32RIPK11.20060823
33MAPK131.19980786
34PNCK1.16571824
35CAMK2A1.13721511
36PDGFRA1.13199112
37BMPR21.10602414
38STK381.08140167
39PTK2B1.06452085
40CAMKK21.04809979
41CAMK2B1.01699274
42MAP3K20.99911574
43DDR20.96821110
44TYRO30.93752546
45UHMK10.90412517
46CDK180.88039107
47CDK140.86460210
48STK110.84805284
49RAF10.83569145
50CDK150.83343919
51CAMK10.82920608
52OXSR10.82823830
53FGR0.78170388
54CAMK1G0.77969978
55SGK2230.77802155
56SGK4940.77802155
57MAPKAPK50.75525806
58CSNK1G20.73478306
59SGK10.71230912
60WNK10.71205677
61CDK11A0.71168343
62LATS20.71162479
63BCR0.70639858
64PHKG10.68676965
65PHKG20.68676965
66TNK20.65595166
67TAOK10.65289712
68PAK30.64824771
69PRKCH0.64410246
70CCNB10.64296030
71PINK10.63191833
72DYRK1A0.62639191
73SIK30.61126344
74FER0.60155361
75PRKCE0.59218298
76RET0.59122862
77PDK10.58650283
78CAMK2D0.58377556
79PDPK10.57795642
80MARK20.55837319
81SGK20.55551518
82PRKCZ0.54013288
83MYLK0.53895365
84NME10.52405047
85DAPK30.51966670
86RPS6KA30.49776668
87ROCK10.49182310
88FYN0.48310194
89LIMK10.47660560
90CAMK2G0.46848283
91MAP3K60.45016505
92PDGFRB0.44851743
93MAP3K10.44802244
94MAP2K10.42505436
95MAPK100.42445594
96ROCK20.41836455
97ALK0.41594176
98SGK30.40241756
99PKN10.39537654
100CAMK1D0.39192850
101PAK20.38287309
102NEK60.37841071
103SCYL20.37790430
104STK390.37224035
105PRKG10.36507445
106PRKCB0.35224838
107TESK10.34670472
108MOS0.34616481
109MAPK120.32108726
110PRKACA0.32014307
111PRKCA0.31295667
112CAMK40.31195033
113MUSK0.31170740
114AKT30.30799341
115CSNK1G30.28176134
116MAP3K70.28147997
117BRAF0.27322989

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.10653277
2Synaptic vesicle cycle_Homo sapiens_hsa047213.17823460
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.92150432
4Long-term potentiation_Homo sapiens_hsa047202.89652379
5Olfactory transduction_Homo sapiens_hsa047402.88805523
6GABAergic synapse_Homo sapiens_hsa047272.85372350
7Circadian entrainment_Homo sapiens_hsa047132.85356777
8Morphine addiction_Homo sapiens_hsa050322.75206754
9Glutamatergic synapse_Homo sapiens_hsa047242.75125680
10Amphetamine addiction_Homo sapiens_hsa050312.66569117
11Dopaminergic synapse_Homo sapiens_hsa047282.26329305
12Salivary secretion_Homo sapiens_hsa049702.25943886
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00057135
14Cholinergic synapse_Homo sapiens_hsa047251.95150276
15Renin secretion_Homo sapiens_hsa049241.90779091
16Gastric acid secretion_Homo sapiens_hsa049711.89827424
17Insulin secretion_Homo sapiens_hsa049111.89675011
18Taste transduction_Homo sapiens_hsa047421.88552807
19Serotonergic synapse_Homo sapiens_hsa047261.87948805
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85057618
21Cocaine addiction_Homo sapiens_hsa050301.84275923
22Oxytocin signaling pathway_Homo sapiens_hsa049211.77543504
23Long-term depression_Homo sapiens_hsa047301.76849708
24Calcium signaling pathway_Homo sapiens_hsa040201.73256182
25Collecting duct acid secretion_Homo sapiens_hsa049661.69527154
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64814793
27GnRH signaling pathway_Homo sapiens_hsa049121.44154717
28Gap junction_Homo sapiens_hsa045401.41257910
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34882059
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30828578
31cAMP signaling pathway_Homo sapiens_hsa040241.27785870
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22652840
33Estrogen signaling pathway_Homo sapiens_hsa049151.18791365
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17428105
35Cardiac muscle contraction_Homo sapiens_hsa042601.15305921
36Axon guidance_Homo sapiens_hsa043601.13631530
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10107384
38Glioma_Homo sapiens_hsa052141.05746931
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04394834
40Vitamin B6 metabolism_Homo sapiens_hsa007501.04118859
41Vibrio cholerae infection_Homo sapiens_hsa051101.03379700
42Melanogenesis_Homo sapiens_hsa049161.00524101
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.99626669
44Phototransduction_Homo sapiens_hsa047440.98295771
45Type II diabetes mellitus_Homo sapiens_hsa049300.96986441
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94175515
47ErbB signaling pathway_Homo sapiens_hsa040120.92686233
48Oocyte meiosis_Homo sapiens_hsa041140.90344550
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88853247
50Pancreatic secretion_Homo sapiens_hsa049720.82075986
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.78806755
52Alzheimers disease_Homo sapiens_hsa050100.77932750
53Thyroid hormone synthesis_Homo sapiens_hsa049180.75079631
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72919312
55Dilated cardiomyopathy_Homo sapiens_hsa054140.71524360
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71211234
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69014863
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68400063
59Choline metabolism in cancer_Homo sapiens_hsa052310.67531866
60Dorso-ventral axis formation_Homo sapiens_hsa043200.66733903
61MAPK signaling pathway_Homo sapiens_hsa040100.66551362
62ECM-receptor interaction_Homo sapiens_hsa045120.66195413
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63814751
64Oxidative phosphorylation_Homo sapiens_hsa001900.61786885
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60337750
66Alcoholism_Homo sapiens_hsa050340.60063131
67Glucagon signaling pathway_Homo sapiens_hsa049220.57386318
68Nitrogen metabolism_Homo sapiens_hsa009100.56778377
69Ras signaling pathway_Homo sapiens_hsa040140.56642989
70African trypanosomiasis_Homo sapiens_hsa051430.54927582
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54862739
72Rap1 signaling pathway_Homo sapiens_hsa040150.53531680
73VEGF signaling pathway_Homo sapiens_hsa043700.52549131
74Protein digestion and absorption_Homo sapiens_hsa049740.51087546
75Type I diabetes mellitus_Homo sapiens_hsa049400.51032480
76Fatty acid biosynthesis_Homo sapiens_hsa000610.50192682
77Focal adhesion_Homo sapiens_hsa045100.50189132
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.47775180
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.46079300
80Prion diseases_Homo sapiens_hsa050200.45852997
81Parkinsons disease_Homo sapiens_hsa050120.45560010
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41545936
83Bile secretion_Homo sapiens_hsa049760.40032761
84Hippo signaling pathway_Homo sapiens_hsa043900.40013697
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39811911
86Inositol phosphate metabolism_Homo sapiens_hsa005620.39513839
87Amoebiasis_Homo sapiens_hsa051460.39366973
88Mineral absorption_Homo sapiens_hsa049780.38889988
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38368579
90mTOR signaling pathway_Homo sapiens_hsa041500.36171910
91Circadian rhythm_Homo sapiens_hsa047100.35182502
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34285040
93Ovarian steroidogenesis_Homo sapiens_hsa049130.32600259
94Prolactin signaling pathway_Homo sapiens_hsa049170.31778313
95Endocytosis_Homo sapiens_hsa041440.31778131
96Wnt signaling pathway_Homo sapiens_hsa043100.31347347
97Tight junction_Homo sapiens_hsa045300.30681141
98Proteoglycans in cancer_Homo sapiens_hsa052050.30528021
99Renal cell carcinoma_Homo sapiens_hsa052110.30471738
100Non-small cell lung cancer_Homo sapiens_hsa052230.30299870
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30269491
102Huntingtons disease_Homo sapiens_hsa050160.29981964
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29961122
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29167624
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28852357
106Rheumatoid arthritis_Homo sapiens_hsa053230.28695444
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28450473
108Chemokine signaling pathway_Homo sapiens_hsa040620.28002604
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27981999
110Platelet activation_Homo sapiens_hsa046110.27922655
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27833169
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27323638
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27051380
114Endometrial cancer_Homo sapiens_hsa052130.26815127
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26543734
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24991473

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »