KCNK5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.68593174
2L-phenylalanine catabolic process (GO:0006559)5.68593174
3L-phenylalanine metabolic process (GO:0006558)5.61796184
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.61796184
5serine family amino acid catabolic process (GO:0009071)5.28485017
6cysteine metabolic process (GO:0006534)5.26947904
7aromatic amino acid family catabolic process (GO:0009074)5.26505489
8urate metabolic process (GO:0046415)5.14855154
9glycine metabolic process (GO:0006544)5.10890164
10indole-containing compound catabolic process (GO:0042436)4.91285795
11indolalkylamine catabolic process (GO:0046218)4.91285795
12tryptophan catabolic process (GO:0006569)4.91285795
13proline biosynthetic process (GO:0006561)4.90756258
14serine family amino acid metabolic process (GO:0009069)4.81618624
15glyoxylate metabolic process (GO:0046487)4.80497163
16NADH metabolic process (GO:0006734)4.68422659
17kynurenine metabolic process (GO:0070189)4.65004582
18lysine metabolic process (GO:0006553)4.55698720
19lysine catabolic process (GO:0006554)4.55698720
20tryptophan metabolic process (GO:0006568)4.54603991
21sulfur amino acid catabolic process (GO:0000098)4.53773271
22serine family amino acid biosynthetic process (GO:0009070)4.53566507
23angiotensin maturation (GO:0002003)4.45113752
24drug catabolic process (GO:0042737)4.42447850
25homocysteine metabolic process (GO:0050667)4.40623839
26DNA unwinding involved in DNA replication (GO:0006268)4.38830087
27drug transmembrane transport (GO:0006855)4.30372224
28alpha-linolenic acid metabolic process (GO:0036109)4.18492031
29epoxygenase P450 pathway (GO:0019373)4.13555587
30amino-acid betaine metabolic process (GO:0006577)4.12829326
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.12608426
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.12038038
33urea metabolic process (GO:0019627)4.10347272
34urea cycle (GO:0000050)4.10347272
35bile acid biosynthetic process (GO:0006699)4.07958331
36nuclear pore complex assembly (GO:0051292)4.04837465
37folic acid metabolic process (GO:0046655)3.99738629
38exogenous drug catabolic process (GO:0042738)3.99391712
39aromatic amino acid family metabolic process (GO:0009072)3.96596938
40drug transport (GO:0015893)3.86842154
41alpha-amino acid catabolic process (GO:1901606)3.86552825
42negative regulation of cholesterol transport (GO:0032375)3.79842661
43negative regulation of sterol transport (GO:0032372)3.79842661
44regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.79751803
45nitrogen cycle metabolic process (GO:0071941)3.72658528
46cellular amino acid catabolic process (GO:0009063)3.65987152
47bile acid metabolic process (GO:0008206)3.60768492
48valine metabolic process (GO:0006573)3.57640777
49pyrimidine nucleoside salvage (GO:0043097)3.57507423
50pyrimidine-containing compound salvage (GO:0008655)3.57507423
51regulation of cholesterol homeostasis (GO:2000188)3.52632989
52flavonoid metabolic process (GO:0009812)3.49859544
53intestinal cholesterol absorption (GO:0030299)3.47990523
54nuclear pore organization (GO:0006999)3.47591638
55negative regulation of fibrinolysis (GO:0051918)3.46466260
56calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.43807396
57fat-soluble vitamin biosynthetic process (GO:0042362)3.43778191
58bile acid and bile salt transport (GO:0015721)3.43572153
59pantothenate metabolic process (GO:0015939)3.43286465
60trophectodermal cell differentiation (GO:0001829)3.42924294
61regulation of protein activation cascade (GO:2000257)3.41839708
62protein complex localization (GO:0031503)3.41072903
63high-density lipoprotein particle remodeling (GO:0034375)3.40065274
64glutamine family amino acid biosynthetic process (GO:0009084)3.39352086
65regulation of triglyceride catabolic process (GO:0010896)3.37845010
66nucleoside salvage (GO:0043174)3.36497149
672-oxoglutarate metabolic process (GO:0006103)3.32792882
68cellular modified amino acid catabolic process (GO:0042219)3.32284944
69biotin metabolic process (GO:0006768)3.31438371
70mitotic chromosome condensation (GO:0007076)3.30767073
71ethanol oxidation (GO:0006069)3.30385118
72heme transport (GO:0015886)3.30156215
73indolalkylamine metabolic process (GO:0006586)3.29218166
74regulation of histone H3-K9 methylation (GO:0051570)3.28477845
75DNA strand elongation involved in DNA replication (GO:0006271)3.28278443
76cellular biogenic amine catabolic process (GO:0042402)3.27857358
77amine catabolic process (GO:0009310)3.27857358
78drug metabolic process (GO:0017144)3.26976226
79acetyl-CoA metabolic process (GO:0006084)3.26528982
80regulation of bile acid biosynthetic process (GO:0070857)3.24392367
81complement activation, alternative pathway (GO:0006957)3.24021698
82regulation of complement activation (GO:0030449)3.22368753
83oxaloacetate metabolic process (GO:0006107)3.21841912
84uronic acid metabolic process (GO:0006063)3.21693930
85glucuronate metabolic process (GO:0019585)3.21693930
86fructose metabolic process (GO:0006000)3.21605795
87peptidyl-glutamic acid carboxylation (GO:0017187)3.19993053
88protein carboxylation (GO:0018214)3.19993053
89acylglycerol homeostasis (GO:0055090)3.19677226
90triglyceride homeostasis (GO:0070328)3.19677226
91tyrosine metabolic process (GO:0006570)3.19476623
92cellular glucuronidation (GO:0052695)3.18929574
93imidazole-containing compound metabolic process (GO:0052803)3.17902693
94benzene-containing compound metabolic process (GO:0042537)3.17311303
95response to mercury ion (GO:0046689)3.15871708
96regulation of fibrinolysis (GO:0051917)3.15466747
97glutamate metabolic process (GO:0006536)3.15183755
98negative regulation of fatty acid biosynthetic process (GO:0045717)3.13176566
99DNA strand elongation (GO:0022616)3.13176083
100one-carbon metabolic process (GO:0006730)3.12616614
101regulation of translational fidelity (GO:0006450)3.12213123
102sterol homeostasis (GO:0055092)3.11677942
103cholesterol homeostasis (GO:0042632)3.11655497
104organic acid catabolic process (GO:0016054)3.10725490
105carboxylic acid catabolic process (GO:0046395)3.10725490
106regulation of guanylate cyclase activity (GO:0031282)3.10662249
107branched-chain amino acid metabolic process (GO:0009081)3.08711799
108cellular ketone body metabolic process (GO:0046950)3.08251716
109short-chain fatty acid metabolic process (GO:0046459)3.07781161
110mitochondrial DNA replication (GO:0006264)3.05148425
111vitamin transmembrane transport (GO:0035461)3.04902913
112mitochondrial DNA metabolic process (GO:0032042)3.04073407
113sulfur amino acid metabolic process (GO:0000096)3.04069443
114negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.04045060
115regulation of cholesterol esterification (GO:0010872)3.03967595
116DNA replication initiation (GO:0006270)3.03703151
117modified amino acid transport (GO:0072337)3.02791203
118aspartate family amino acid catabolic process (GO:0009068)3.02603275
119glucose 6-phosphate metabolic process (GO:0051156)3.01592312
120cellular protein complex localization (GO:0034629)3.00950070
121L-serine metabolic process (GO:0006563)3.00454221
122branched-chain amino acid catabolic process (GO:0009083)2.99542244
123nucleobase biosynthetic process (GO:0046112)2.98578820
124mRNA stabilization (GO:0048255)2.96953987
125RNA stabilization (GO:0043489)2.96953987
126bundle of His cell to Purkinje myocyte communication (GO:0086069)2.94168163
127proline metabolic process (GO:0006560)2.93383996
128carnitine metabolic process (GO:0009437)2.93331800
129intestinal absorption (GO:0050892)2.92852417
130hematopoietic stem cell differentiation (GO:0060218)2.92526491
131coenzyme catabolic process (GO:0009109)2.91495705
132regulation of vitamin metabolic process (GO:0030656)2.91342853
133heterochromatin organization (GO:0070828)2.90998611
134negative regulation of histone methylation (GO:0031061)2.90993421
135hormone catabolic process (GO:0042447)2.90921451
136negative regulation of transcription by competitive promoter binding (GO:0010944)2.86522645
137regulation of RNA export from nucleus (GO:0046831)2.83922846
138formation of translation preinitiation complex (GO:0001731)2.79491651
139cellular response to nitric oxide (GO:0071732)2.79416647
140embryonic process involved in female pregnancy (GO:0060136)2.78107000
141citrulline biosynthetic process (GO:0019240)2.76987567
142midgut development (GO:0007494)2.75305921
143lipoprotein transport (GO:0042953)2.72391823
144pre-miRNA processing (GO:0031054)2.69244590
145protein localization to kinetochore (GO:0034501)2.66038794
146protein localization to chromosome, centromeric region (GO:0071459)2.65811622
147pore complex assembly (GO:0046931)2.63995861
148establishment of integrated proviral latency (GO:0075713)2.62101002
149regulation of chromatin silencing (GO:0031935)2.62043038
150antibacterial humoral response (GO:0019731)2.61186217
151mitotic nuclear envelope disassembly (GO:0007077)2.58249500
152pentose-phosphate shunt (GO:0006098)2.58138740
153L-alpha-amino acid transmembrane transport (GO:1902475)2.57215991
154negative regulation of gene silencing (GO:0060969)2.56646516
155negative regulation of erythrocyte differentiation (GO:0045647)2.54685097
156telomere maintenance via semi-conservative replication (GO:0032201)2.54462179
157negative regulation of epidermis development (GO:0045683)2.54400872
158epithelial cell-cell adhesion (GO:0090136)2.53435340
159NADPH regeneration (GO:0006740)2.51930877
160very-low-density lipoprotein particle assembly (GO:0034379)2.51656583
161DNA replication checkpoint (GO:0000076)2.50825470
162tight junction assembly (GO:0070830)2.50704778
163nucleotide-sugar biosynthetic process (GO:0009226)2.50594802
164surfactant homeostasis (GO:0043129)2.50304688
165negative regulation of mRNA processing (GO:0050686)2.49352690
166antimicrobial humoral response (GO:0019730)2.48975943
167receptor guanylyl cyclase signaling pathway (GO:0007168)2.48075948
168vitamin transport (GO:0051180)2.47046125
169negative regulation of RNA splicing (GO:0033119)2.46626866
170negative regulation of mRNA metabolic process (GO:1903312)2.46321281
171negative regulation of cell fate specification (GO:0009996)2.46281483
172protein autoprocessing (GO:0016540)2.45268717
173positive regulation of Cdc42 GTPase activity (GO:0043089)2.44780655
174negative regulation of epidermal cell differentiation (GO:0045605)2.44280721
175regulation of nucleobase-containing compound transport (GO:0032239)2.43083240
176renal system process involved in regulation of blood volume (GO:0001977)2.40300439
177DNA duplex unwinding (GO:0032508)2.39442370
178citrulline metabolic process (GO:0000052)2.34759366
179chromatin assembly (GO:0031497)2.34300101
180DNA topological change (GO:0006265)2.34026471
181nucleoside diphosphate biosynthetic process (GO:0009133)2.33942931
182GDP-mannose metabolic process (GO:0019673)2.33275963
183COPI coating of Golgi vesicle (GO:0048205)2.32558319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.90598233
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.84213455
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.40815031
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.95279040
5E2F7_22180533_ChIP-Seq_HELA_Human3.90754788
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.54607513
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.25039991
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.11677609
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.83144015
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.75795838
11* MYC_18555785_ChIP-Seq_MESCs_Mouse2.28583036
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.22432665
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07288972
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04955992
15ZNF263_19887448_ChIP-Seq_K562_Human2.02084180
16* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.00111260
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.94386399
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.94386399
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.94386399
20STAT3_1855785_ChIP-Seq_MESCs_Mouse1.93767360
21AR_21909140_ChIP-Seq_LNCAP_Human1.80307730
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76622030
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.72625363
24SCL_19346495_ChIP-Seq_HPC-7_Human1.72363804
25MYC_22102868_ChIP-Seq_BL_Human1.71820869
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64216423
27* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59310724
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58613522
29* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58368631
30LXR_22292898_ChIP-Seq_THP-1_Human1.56880449
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.56363310
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54346530
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53757209
34NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51313624
35* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50253801
36KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49754257
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48392993
38GATA1_22025678_ChIP-Seq_K562_Human1.47587697
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47005058
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45315031
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42912311
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42293251
43* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.40446200
44* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39892526
45NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.39263474
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38660006
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30649889
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.30315887
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27864173
50* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24402618
51TCF7_22412390_ChIP-Seq_EML_Mouse1.23597706
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.21399855
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21156915
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18497749
55CLOCK_20551151_ChIP-Seq_293T_Human1.18292252
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16235214
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13527385
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11348928
59* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10442915
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07627698
61* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06954154
62ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05688075
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.04661697
64TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04389842
65CHD1_26751641_Chip-Seq_LNCaP_Human1.03818500
66GATA1_19941826_ChIP-Seq_K562_Human1.03715103
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03264667
68* NOTCH1_21737748_ChIP-Seq_TLL_Human1.02838342
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01166933
70RUNX1_27514584_Chip-Seq_MCF-7_Human1.00606486
71SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99968950
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99484615
73CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98945476
74CREB1_26743006_Chip-Seq_LNCaP_Human0.98859079
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98023530
76CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97731545
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97469732
78TET1_21451524_ChIP-Seq_MESCs_Mouse0.97383112
79* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97083150
80TTF2_22483619_ChIP-Seq_HELA_Human0.96037135
81* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95118544
82SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93312042
83GATA4_25053715_ChIP-Seq_YYC3_Human0.93068217
84ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92771319
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92609320
86OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92553205
87JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.92258824
88THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91998034
89GATA6_25053715_ChIP-Seq_YYC3_Human0.91856532
90HNF4A_19822575_ChIP-Seq_HepG2_Human0.90930697
91E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90590653
92RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90197819
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90066744
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89950914
95ESR2_21235772_ChIP-Seq_MCF-7_Human0.89802260
96MYCN_18555785_ChIP-Seq_MESCs_Mouse0.89675584
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89466273
98XRN2_22483619_ChIP-Seq_HELA_Human0.89449417
99* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88677469
100P68_20966046_ChIP-Seq_HELA_Human0.88548145
101VDR_24763502_ChIP-Seq_THP-1_Human0.87704737
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86297840
103SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85550981
104CDX2_20551321_ChIP-Seq_CACO-2_Human0.83731515
105VDR_21846776_ChIP-Seq_THP-1_Human0.83398011
106ETS1_20019798_ChIP-Seq_JURKAT_Human0.82460543
107NCOR1_26117541_ChIP-Seq_K562_Human0.81635271
108E2F1_21310950_ChIP-Seq_MCF-7_Human0.81272956
109NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80714577
110FOXP3_21729870_ChIP-Seq_TREG_Human0.80025224
111* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.79473036
112DCP1A_22483619_ChIP-Seq_HELA_Human0.79351570
113IRF8_22096565_ChIP-ChIP_GC-B_Human0.79131057
114IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.79070430
115SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78913728
116* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78583021
117RACK7_27058665_Chip-Seq_MCF-7_Human0.78536490
118POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.77748231
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77633350
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76868600
121ELF1_17652178_ChIP-ChIP_JURKAT_Human0.76473685
122GABP_19822575_ChIP-Seq_HepG2_Human0.76337648
123MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.76262365
124ELK3_25401928_ChIP-Seq_HUVEC_Human0.76124174
125E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.75913263
126* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.75598241
127ZFX_18555785_ChIP-Seq_MESCs_Mouse0.75505706
128EST1_17652178_ChIP-ChIP_JURKAT_Human0.75322866
129ATF3_27146783_Chip-Seq_COLON_Human0.74530916
130POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.74523793
131KDM5A_27292631_Chip-Seq_BREAST_Human0.73558233
132KAP1_27257070_Chip-Seq_ESCs_Mouse0.72958133

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.91816253
2MP0002139_abnormal_hepatobiliary_system6.27718405
3MP0005085_abnormal_gallbladder_physiolo4.84453716
4MP0005365_abnormal_bile_salt4.36576096
5MP0008875_abnormal_xenobiotic_pharmacok4.19201963
6MP0003806_abnormal_nucleotide_metabolis3.69017713
7MP0003252_abnormal_bile_duct3.13469423
8MP0004019_abnormal_vitamin_homeostasis2.93245700
9MP0010329_abnormal_lipoprotein_level2.69770363
10MP0009840_abnormal_foam_cell2.65068194
11MP0005332_abnormal_amino_acid2.65047437
12MP0001666_abnormal_nutrient_absorption2.53704679
13MP0009379_abnormal_foot_pigmentation2.29918114
14MP0002138_abnormal_hepatobiliary_system2.26108217
15MP0003191_abnormal_cellular_cholesterol2.22822930
16MP0004264_abnormal_extraembryonic_tissu1.98489104
17MP0004782_abnormal_surfactant_physiolog1.96505025
18MP0000609_abnormal_liver_physiology1.80815084
19MP0005083_abnormal_biliary_tract1.71944448
20MP0009643_abnormal_urine_homeostasis1.71844829
21MP0000678_abnormal_parathyroid_gland1.70698907
22MP0005319_abnormal_enzyme/_coenzyme1.61095933
23MP0005076_abnormal_cell_differentiation1.58120436
24MP0004185_abnormal_adipocyte_glucose1.56720685
25MP0003868_abnormal_feces_composition1.56014729
26MP0000566_synostosis1.54303944
27MP0003195_calcinosis1.51477787
28MP0008932_abnormal_embryonic_tissue1.50945343
29MP0002118_abnormal_lipid_homeostasis1.49478597
30MP0003718_maternal_effect1.44672346
31MP0000462_abnormal_digestive_system1.43145368
32MP0001849_ear_inflammation1.40207291
33MP0002254_reproductive_system_inflammat1.36578341
34MP0005451_abnormal_body_composition1.35316877
35MP0001664_abnormal_digestion1.32489471
36MP0010234_abnormal_vibrissa_follicle1.32210923
37MP0009672_abnormal_birth_weight1.26511456
38MP0001764_abnormal_homeostasis1.26462437
39MP0003705_abnormal_hypodermis_morpholog1.26379692
40MP0000598_abnormal_liver_morphology1.25664311
41MP0000350_abnormal_cell_proliferation1.23307527
42MP0002098_abnormal_vibrissa_morphology1.20276750
43MP0005636_abnormal_mineral_homeostasis1.20251547
44MP0003693_abnormal_embryo_hatching1.15330804
45MP0010307_abnormal_tumor_latency1.13596070
46MP0005666_abnormal_adipose_tissue1.13356709
47MP0003183_abnormal_peptide_metabolism1.13348247
48MP0003186_abnormal_redox_activity1.11715158
49MP0004957_abnormal_blastocyst_morpholog1.10237414
50MP0003866_abnormal_defecation1.09175989
51MP0001881_abnormal_mammary_gland1.07278190
52MP0006036_abnormal_mitochondrial_physio1.06191327
53MP0005584_abnormal_enzyme/coenzyme_acti1.05792264
54MP0002396_abnormal_hematopoietic_system1.05088270
55* MP0002080_prenatal_lethality1.04445436
56MP0002132_abnormal_respiratory_system1.03595187
57MP0005381_digestive/alimentary_phenotyp1.02582661
58MP0005248_abnormal_Harderian_gland1.01567238
59MP0001697_abnormal_embryo_size1.01318262
60* MP0002136_abnormal_kidney_physiology1.01048669
61MP0005409_darkened_coat_color0.99274309
62MP0009697_abnormal_copulation0.97557870
63MP0004147_increased_porphyrin_level0.96464196
64MP0003656_abnormal_erythrocyte_physiolo0.94949099
65MP0002085_abnormal_embryonic_tissue0.94105188
66MP0000313_abnormal_cell_death0.93715574
67MP0003123_paternal_imprinting0.93602261
68MP0002089_abnormal_postnatal_growth/wei0.93271805
69MP0001663_abnormal_digestive_system0.92533564
70MP0004947_skin_inflammation0.90218611
71MP0003566_abnormal_cell_adhesion0.89445083
72MP0010094_abnormal_chromosome_stability0.88153737
73MP0002084_abnormal_developmental_patter0.86343764
74MP0001216_abnormal_epidermal_layer0.86288581
75MP0009278_abnormal_bone_marrow0.85940988
76MP0010352_gastrointestinal_tract_polyps0.85850175
77MP0001756_abnormal_urination0.85540845
78MP0009763_increased_sensitivity_to0.83351674
79MP0009931_abnormal_skin_appearance0.82899521
80MP0008058_abnormal_DNA_repair0.82562197
81MP0005647_abnormal_sex_gland0.82407544
82MP0005395_other_phenotype0.82127139
83MP0005220_abnormal_exocrine_pancreas0.82003289
84MP0000377_abnormal_hair_follicle0.81667255
85MP0004043_abnormal_pH_regulation0.81048397
86MP0000490_abnormal_crypts_of0.79857786
87MP0004858_abnormal_nervous_system0.79276018
88MP0005464_abnormal_platelet_physiology0.79221589
89MP0005377_hearing/vestibular/ear_phenot0.79099507
90MP0003878_abnormal_ear_physiology0.79099507
91MP0008057_abnormal_DNA_replication0.77707130
92MP0000627_abnormal_mammary_gland0.77240883
93MP0003011_delayed_dark_adaptation0.76159691
94MP0003077_abnormal_cell_cycle0.75722124
95MP0008469_abnormal_protein_level0.75627265
96MP0001873_stomach_inflammation0.74864729
97MP0003119_abnormal_digestive_system0.74518300
98MP0009765_abnormal_xenobiotic_induced0.73774973
99MP0002796_impaired_skin_barrier0.73328171
100MP0001765_abnormal_ion_homeostasis0.73008473
101MP0010678_abnormal_skin_adnexa0.72856046
102MP0003111_abnormal_nucleus_morphology0.72026206
103MP0003638_abnormal_response/metabolism_0.72006789
104MP0001188_hyperpigmentation0.71585894
105MP0001661_extended_life_span0.71535310
106MP0008995_early_reproductive_senescence0.70915475
107MP0003567_abnormal_fetal_cardiomyocyte0.69633390
108MP0002009_preneoplasia0.68704771
109MP0001545_abnormal_hematopoietic_system0.68364334
110MP0005397_hematopoietic_system_phenotyp0.68364334
111MP0003890_abnormal_embryonic-extraembry0.68000515
112MP0002086_abnormal_extraembryonic_tissu0.67916989
113MP0003300_gastrointestinal_ulcer0.66473682
114MP0009642_abnormal_blood_homeostasis0.66121848
115MP0005084_abnormal_gallbladder_morpholo0.65903963
116MP0001727_abnormal_embryo_implantation0.65426128
117MP0005670_abnormal_white_adipose0.65331841
118MP0006035_abnormal_mitochondrial_morpho0.64671713
119MP0000477_abnormal_intestine_morphology0.63906618
120MP0004808_abnormal_hematopoietic_stem0.63651903
121MP0003763_abnormal_thymus_physiology0.63414922
122MP0009764_decreased_sensitivity_to0.62453387
123MP0003941_abnormal_skin_development0.62179849
124MP0005167_abnormal_blood-brain_barrier0.60381368
125MP0010155_abnormal_intestine_physiology0.60218447
126MP0003943_abnormal_hepatobiliary_system0.60048339
127MP0001730_embryonic_growth_arrest0.59476839
128MP0000689_abnormal_spleen_morphology0.59311374
129MP0005380_embryogenesis_phenotype0.58365464
130MP0001672_abnormal_embryogenesis/_devel0.58365464
131MP0003453_abnormal_keratinocyte_physiol0.57660331
132MP0000465_gastrointestinal_hemorrhage0.57393155
133MP0009333_abnormal_splenocyte_physiolog0.57040219
134MP0005671_abnormal_response_to0.55941064
135MP0001853_heart_inflammation0.55793988
136MP0000537_abnormal_urethra_morphology0.55444784
137MP0005266_abnormal_metabolism0.54751716
138MP0005376_homeostasis/metabolism_phenot0.54380703
139MP0005023_abnormal_wound_healing0.54107753
140MP0002088_abnormal_embryonic_growth/wei0.53330321
141MP0002722_abnormal_immune_system0.52625118
142MP0005501_abnormal_skin_physiology0.52032580
143MP0003984_embryonic_growth_retardation0.51965616

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.53918903
2Intrahepatic cholestasis (HP:0001406)5.46197480
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.27852637
4Hyperglycinuria (HP:0003108)5.04803586
5Gout (HP:0001997)4.80783347
6Xanthomatosis (HP:0000991)4.76289293
7Hyperglycinemia (HP:0002154)4.63250298
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.59326475
9Hypobetalipoproteinemia (HP:0003563)4.50196532
10Abnormality of glycine metabolism (HP:0010895)4.49641066
11Abnormality of serine family amino acid metabolism (HP:0010894)4.49641066
12Deep venous thrombosis (HP:0002625)4.44488058
13Hyperammonemia (HP:0001987)3.94378078
14Hyperlipoproteinemia (HP:0010980)3.88829030
15Ileus (HP:0002595)3.81838897
16Abnormality of sulfur amino acid metabolism (HP:0004339)3.77191312
17Abnormality of aspartate family amino acid metabolism (HP:0010899)3.70064898
18Abnormality of pyrimidine metabolism (HP:0004353)3.66497063
19Abnormality of nucleobase metabolism (HP:0010932)3.64100669
20Abnormality of purine metabolism (HP:0004352)3.62902473
21Prolonged partial thromboplastin time (HP:0003645)3.46784860
22Delayed CNS myelination (HP:0002188)3.25848326
23Ragged-red muscle fibers (HP:0003200)3.24542067
24Abnormality of the heme biosynthetic pathway (HP:0010472)3.21884324
25Hypolipoproteinemia (HP:0010981)3.19283381
26Pili torti (HP:0003777)3.18354936
27Ketosis (HP:0001946)3.14864900
28Hyperuricemia (HP:0002149)3.12742474
29Increased purine levels (HP:0004368)3.12742474
30Abnormality of fatty-acid metabolism (HP:0004359)3.11459526
31Fat malabsorption (HP:0002630)3.07606267
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.07094016
33Abnormality of methionine metabolism (HP:0010901)3.02456630
34Abnormality of serum amino acid levels (HP:0003112)2.99422898
35Hepatocellular carcinoma (HP:0001402)2.97512053
36Hypochromic microcytic anemia (HP:0004840)2.95982360
37Joint hemorrhage (HP:0005261)2.91830444
38Irritability (HP:0000737)2.90553737
39Chronic diarrhea (HP:0002028)2.90399714
40Hypercholesterolemia (HP:0003124)2.87852141
41Malnutrition (HP:0004395)2.87755832
42Complement deficiency (HP:0004431)2.85554769
43Right ventricular cardiomyopathy (HP:0011663)2.78869962
44Proximal tubulopathy (HP:0000114)2.78613845
45Menorrhagia (HP:0000132)2.78083893
46Epidermoid cyst (HP:0200040)2.75165702
47Seborrheic dermatitis (HP:0001051)2.67126903
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.66169263
49Abnormality of the intrinsic pathway (HP:0010989)2.65841852
50Abnormal gallbladder physiology (HP:0012438)2.62092208
51Cholecystitis (HP:0001082)2.62092208
52Reticulocytosis (HP:0001923)2.57462721
53Hypoalphalipoproteinemia (HP:0003233)2.56755440
54Spastic diplegia (HP:0001264)2.51850151
55Abnormality of the common coagulation pathway (HP:0010990)2.50285925
56Abdominal distention (HP:0003270)2.49464735
57Lethargy (HP:0001254)2.48040231
58Abnormality of reticulocytes (HP:0004312)2.47653707
59Hyperbilirubinemia (HP:0002904)2.44245623
60Alkalosis (HP:0001948)2.43870296
61Hydroxyprolinuria (HP:0003080)2.43583467
62Abnormality of proline metabolism (HP:0010907)2.43583467
63Metabolic acidosis (HP:0001942)2.39542306
64Abnormal hair laboratory examination (HP:0003328)2.37318199
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37314506
66Dicarboxylic aciduria (HP:0003215)2.37314506
67Abnormality of the vitamin B12 metabolism (HP:0004341)2.36232973
68Rickets (HP:0002748)2.34977437
69Vascular calcification (HP:0004934)2.33384693
70Flat acetabular roof (HP:0003180)2.30675174
71Reticulocytopenia (HP:0001896)2.26945788
72Facial diplegia (HP:0001349)2.26904964
73Generalized aminoaciduria (HP:0002909)2.26733767
74Impaired platelet aggregation (HP:0003540)2.25978525
75Abnormal platelet function (HP:0011869)2.25978525
76Spontaneous abortion (HP:0005268)2.25508944
77Esophageal varix (HP:0002040)2.22851678
78Abnormality of the fingertips (HP:0001211)2.22560996
79Conjugated hyperbilirubinemia (HP:0002908)2.22040167
80Abnormal cartilage morphology (HP:0002763)2.17806459
81Villous atrophy (HP:0011473)2.17133226
82Abnormality of small intestinal villus morphology (HP:0011472)2.17133226
83Steatorrhea (HP:0002570)2.15692085
84Abnormal enzyme/coenzyme activity (HP:0012379)2.11690215
85Urethral obstruction (HP:0000796)2.11297053
86Birth length less than 3rd percentile (HP:0003561)2.08121001
87Widely patent fontanelles and sutures (HP:0004492)2.07803572
88Ketoacidosis (HP:0001993)2.06668599
89Truncus arteriosus (HP:0001660)2.06400236
90Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05925906
91Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05925906
92Nephrolithiasis (HP:0000787)2.05085114
93Abnormality of the salivary glands (HP:0010286)2.04738392
94Hypoglycemic coma (HP:0001325)2.04551556
95Premature ovarian failure (HP:0008209)2.03158206
96Gingival bleeding (HP:0000225)2.02962531
97Megaloblastic anemia (HP:0001889)2.02570765
98Abnormality of vitamin B metabolism (HP:0004340)2.02497114
99Abnormality of the gastric mucosa (HP:0004295)1.97592663
100Hyperactive renin-angiotensin system (HP:0000841)1.96804814
101Cardiovascular calcification (HP:0011915)1.95719622
102Abnormality of alkaline phosphatase activity (HP:0004379)1.95058571
103Acanthocytosis (HP:0001927)1.94969829
104Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94717645
105Wide cranial sutures (HP:0010537)1.92855270
106Gastrointestinal dysmotility (HP:0002579)1.91454952
107Abnormality of complement system (HP:0005339)1.91029059
108Delayed epiphyseal ossification (HP:0002663)1.88666359
109Dysmetric saccades (HP:0000641)1.86964693
110Abnormality of transition element cation homeostasis (HP:0011030)1.86510195
111Poikilocytosis (HP:0004447)1.86141565
112Glycosuria (HP:0003076)1.85804453
113Abnormality of urine glucose concentration (HP:0011016)1.85804453
114Nausea (HP:0002018)1.85229502
115Macrocytic anemia (HP:0001972)1.84651965
116Skull defect (HP:0001362)1.84450012
117Progressive muscle weakness (HP:0003323)1.83669425
118Segmental peripheral demyelination/remyelination (HP:0003481)1.83098351
119Sensorimotor neuropathy (HP:0007141)1.83037899
120Progressive hearing impairment (HP:0001730)1.82599478
121Impaired proprioception (HP:0010831)1.82561085
122Pancreatitis (HP:0001733)1.82502052
123Abnormality of cells of the erythroid lineage (HP:0012130)1.81359195
124Confusion (HP:0001289)1.81328703
125Disproportionate tall stature (HP:0001519)1.78912809
126Homocystinuria (HP:0002156)1.77466057
127Abnormality of homocysteine metabolism (HP:0010919)1.77466057
128Hemorrhage of the eye (HP:0011885)1.76922679
129Ankyloglossia (HP:0010296)1.75922921
130Abnormality of iron homeostasis (HP:0011031)1.75227972
131Increased serum ferritin (HP:0003281)1.74220686
132Abnormal hemoglobin (HP:0011902)1.74012369
133External ophthalmoplegia (HP:0000544)1.73870310
134Pustule (HP:0200039)1.73353104
135Chromsome breakage (HP:0040012)1.73115227
136Hypokalemic alkalosis (HP:0001949)1.72890048
137Multiple enchondromatosis (HP:0005701)1.72722836
138Abnormality of vitamin metabolism (HP:0100508)1.71918780
139Abnormal tarsal ossification (HP:0008369)1.71651346
140Hypotension (HP:0002615)1.71085826
141Late onset (HP:0003584)1.70622136
142Cerebral palsy (HP:0100021)1.69346079
143Abnormality of chloride homeostasis (HP:0011422)1.69208842
144Biliary tract neoplasm (HP:0100574)1.69125002
145Abnormality of the distal phalanx of the thumb (HP:0009617)1.68842700
146Impulsivity (HP:0100710)1.68745952
147Vomiting (HP:0002013)1.68728157
148Selective tooth agenesis (HP:0001592)1.68096636
149Focal segmental glomerulosclerosis (HP:0000097)1.68043408
150Thrombophlebitis (HP:0004418)1.67622710
151IgA deficiency (HP:0002720)1.67613382
152Malignant gastrointestinal tract tumors (HP:0006749)1.67486956
153Gastrointestinal carcinoma (HP:0002672)1.67486956
154Partial duplication of thumb phalanx (HP:0009944)1.67251212
155Abnormal number of erythroid precursors (HP:0012131)1.65403847
156Abnormality of renin-angiotensin system (HP:0000847)1.64827917
157Abnormality of the thoracic spine (HP:0100711)1.62807570
158Glomerulosclerosis (HP:0000096)1.62041743
159Azoospermia (HP:0000027)1.60806192
160Symptomatic seizures (HP:0011145)1.60214511
161High anterior hairline (HP:0009890)1.59359405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.32393427
2BCKDK4.18237135
3SMG13.47736958
4WEE12.88092507
5CDK122.81604715
6SIK12.44923911
7MAP4K12.37644084
8NME22.19920656
9ERN12.16464766
10FGFR42.09612535
11PRPF4B1.88568924
12PBK1.87185955
13BUB11.75864073
14NME11.75862156
15NEK21.75305523
16PKN21.71817889
17CDK41.67109711
18MST1R1.62850944
19BRSK21.61628414
20SRPK11.61193844
21EEF2K1.58852416
22GRK61.54847799
23RPS6KB21.54182981
24MATK1.53438313
25LMTK21.52627319
26TIE11.50930745
27MAPK111.49142719
28MST41.48317194
29CDK71.37745752
30WNK41.34426079
31TGFBR11.32705373
32DYRK31.31897366
33MAP3K111.30843996
34STK101.29266661
35TTK1.27027001
36FLT31.26666960
37CDK61.24432081
38WNK31.23541552
39MAP2K31.21701505
40TGFBR21.13035711
41TYK21.12968340
42LATS11.12625673
43PIM11.07477381
44MAP3K81.06935911
45CLK11.05200102
46KSR21.05171579
47SCYL21.03570666
48VRK21.03391633
49PDK31.03304127
50PDK41.03304127
51BLK0.99141103
52MAP3K100.98987166
53MAP3K30.95219896
54PAK40.94186226
55OXSR10.91578202
56ZAP700.90774530
57PASK0.88736583
58STK30.88487836
59MAP2K20.86865376
60KDR0.85467709
61CDC70.84032713
62TESK20.82201380
63RIPK10.81563315
64AKT30.81462711
65KIT0.81084908
66ACVR1B0.81050392
67STK240.79902159
68EIF2AK10.78885480
69AURKB0.78400148
70LRRK20.77054756
71BTK0.76934853
72TSSK60.76586253
73CSNK1G10.76460634
74PRKD20.76245722
75PLK10.75995977
76LATS20.75683351
77FGFR30.74618194
78PLK40.74460980
79STK38L0.73544680
80MKNK20.73420235
81PTK60.72008205
82JAK20.70403000
83ICK0.68044701
84BRD40.67856313
85MAP3K10.66902352
86ERBB40.66888766
87NEK10.66651944
88MET0.66649423
89PRKAA20.66622608
90CSNK1G30.65546405
91CHEK20.64948495
92TAOK20.64340084
93RPS6KA40.64017644
94CSF1R0.63021959
95DMPK0.62329617
96GSK3A0.61482248
97TAOK30.61212797
98STK40.60640693
99CSK0.60381415
100PRKG20.60306173
101MTOR0.58480501
102ADRBK20.57941544
103TRIB30.57859341
104GRK10.56415969
105IRAK30.56323502
106ATR0.55721395
107MAP2K60.55349115
108DYRK1B0.55053587
109PDK20.54329376
110MKNK10.54119607
111CDK20.52925123
112ABL20.50763761
113MAPK40.50372814
114MAPK70.48680984
115TNIK0.47802951
116ALK0.47547996
117CHEK10.46533240
118TAF10.45927849
119IKBKB0.43684680
120ZAK0.43579178
121CDK10.43578841
122PRKCI0.43544541
123BMX0.43367479
124CSNK1A1L0.42957474
125RIPK40.42793373
126CAMK1D0.40245510
127CDK90.39174237
128PDPK10.39122310
129AURKA0.39035248
130MAP3K20.38024997
131DAPK10.37945524
132ATM0.36413476
133PDGFRA0.35300001
134STK390.35003077
135RAF10.34640826
136NLK0.34200356
137PLK30.32821732
138TAOK10.31196601
139RPS6KA10.30914878
140CSNK1E0.29654436
141MELK0.28371815
142PAK10.27309010
143FGFR10.26168442

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.28116816
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.25971217
3Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.67089836
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66914967
5Nitrogen metabolism_Homo sapiens_hsa009102.56556117
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.48418833
7Selenocompound metabolism_Homo sapiens_hsa004502.45199723
8Drug metabolism - other enzymes_Homo sapiens_hsa009832.43516278
9Arginine biosynthesis_Homo sapiens_hsa002202.39083830
10Folate biosynthesis_Homo sapiens_hsa007902.37944190
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.37521556
12Tryptophan metabolism_Homo sapiens_hsa003802.33605485
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31511806
14Fatty acid degradation_Homo sapiens_hsa000712.09871820
15Caffeine metabolism_Homo sapiens_hsa002322.06812467
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.06039018
17Butanoate metabolism_Homo sapiens_hsa006501.95700046
18Vitamin B6 metabolism_Homo sapiens_hsa007501.86312528
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.83530351
20Peroxisome_Homo sapiens_hsa041461.81463501
21Vitamin digestion and absorption_Homo sapiens_hsa049771.76123413
22Complement and coagulation cascades_Homo sapiens_hsa046101.75623628
23Propanoate metabolism_Homo sapiens_hsa006401.71819484
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67322398
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66104423
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58089472
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.57645651
28PPAR signaling pathway_Homo sapiens_hsa033201.57514194
29Histidine metabolism_Homo sapiens_hsa003401.56689356
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.56679511
31Chemical carcinogenesis_Homo sapiens_hsa052041.53316019
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52791239
33beta-Alanine metabolism_Homo sapiens_hsa004101.51751952
34Biosynthesis of amino acids_Homo sapiens_hsa012301.47925734
35Fatty acid metabolism_Homo sapiens_hsa012121.45279302
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.42810596
37One carbon pool by folate_Homo sapiens_hsa006701.39902593
38Bile secretion_Homo sapiens_hsa049761.35925471
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35385095
40Pyruvate metabolism_Homo sapiens_hsa006201.32120565
41Fat digestion and absorption_Homo sapiens_hsa049751.29113940
42Retinol metabolism_Homo sapiens_hsa008301.29031543
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28779686
44Sulfur relay system_Homo sapiens_hsa041221.26333680
45Starch and sucrose metabolism_Homo sapiens_hsa005001.25788491
46Carbon metabolism_Homo sapiens_hsa012001.17427767
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09470380
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08058015
49Glutathione metabolism_Homo sapiens_hsa004801.07777985
50Arginine and proline metabolism_Homo sapiens_hsa003301.06113032
51Sulfur metabolism_Homo sapiens_hsa009201.05982173
52Pentose phosphate pathway_Homo sapiens_hsa000301.05527514
53Phenylalanine metabolism_Homo sapiens_hsa003601.05196569
54ABC transporters_Homo sapiens_hsa020101.01153273
55mRNA surveillance pathway_Homo sapiens_hsa030150.92849478
56Lysine degradation_Homo sapiens_hsa003100.92029425
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.90310064
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89958833
59Glycerolipid metabolism_Homo sapiens_hsa005610.88884147
60Staphylococcus aureus infection_Homo sapiens_hsa051500.86181572
61Pyrimidine metabolism_Homo sapiens_hsa002400.84894446
62Tyrosine metabolism_Homo sapiens_hsa003500.84516259
63Galactose metabolism_Homo sapiens_hsa000520.80765600
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80285540
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77420009
66Steroid biosynthesis_Homo sapiens_hsa001000.75123629
67DNA replication_Homo sapiens_hsa030300.73339743
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72182664
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.71777756
70Fructose and mannose metabolism_Homo sapiens_hsa000510.70414458
71Fatty acid biosynthesis_Homo sapiens_hsa000610.67792037
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66101209
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65695106
74Acute myeloid leukemia_Homo sapiens_hsa052210.65344405
75Fatty acid elongation_Homo sapiens_hsa000620.64324586
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62993688
77Mismatch repair_Homo sapiens_hsa034300.61735763
78Chronic myeloid leukemia_Homo sapiens_hsa052200.59666698
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59576514
80Tight junction_Homo sapiens_hsa045300.55731897
81Other glycan degradation_Homo sapiens_hsa005110.55692838
82Metabolic pathways_Homo sapiens_hsa011000.55050682
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54954792
84Hepatitis C_Homo sapiens_hsa051600.54844559
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54274464
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49154062
87Base excision repair_Homo sapiens_hsa034100.46962020
88Adherens junction_Homo sapiens_hsa045200.45737937
89N-Glycan biosynthesis_Homo sapiens_hsa005100.45512722
90Viral carcinogenesis_Homo sapiens_hsa052030.45423217
91Ribosome_Homo sapiens_hsa030100.43880402
92RNA polymerase_Homo sapiens_hsa030200.42004800
93Sphingolipid metabolism_Homo sapiens_hsa006000.41451778
94Renin-angiotensin system_Homo sapiens_hsa046140.39941647
95Systemic lupus erythematosus_Homo sapiens_hsa053220.39668100
96Non-homologous end-joining_Homo sapiens_hsa034500.39082718
97RNA transport_Homo sapiens_hsa030130.36673531
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36486468
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33789686
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.33364279
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.32975905
102Mineral absorption_Homo sapiens_hsa049780.30761581
103MicroRNAs in cancer_Homo sapiens_hsa052060.29000569
104Herpes simplex infection_Homo sapiens_hsa051680.25838450
105Linoleic acid metabolism_Homo sapiens_hsa005910.23894125
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21868607
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20971465
108Insulin signaling pathway_Homo sapiens_hsa049100.20745921
109p53 signaling pathway_Homo sapiens_hsa041150.19595597
110Spliceosome_Homo sapiens_hsa030400.18820655
111Insulin resistance_Homo sapiens_hsa049310.17218474
112Purine metabolism_Homo sapiens_hsa002300.15556804
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.11389433
114* Protein digestion and absorption_Homo sapiens_hsa049740.09492897
115Thyroid cancer_Homo sapiens_hsa052160.08628157
116Arachidonic acid metabolism_Homo sapiens_hsa005900.07127668
117Cell cycle_Homo sapiens_hsa041100.06578272
118Homologous recombination_Homo sapiens_hsa034400.05575630
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.04902342
120AMPK signaling pathway_Homo sapiens_hsa041520.04303217
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.01223439
122Bladder cancer_Homo sapiens_hsa05219-0.0062657

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