KCNK17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of T-helper cell differentiation (GO:0045623)6.04467473
2negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)6.04467473
3regulation of T-helper 1 cell differentiation (GO:0045625)5.05480422
4negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.90225543
5endothelium development (GO:0003158)4.82231633
6indole-containing compound catabolic process (GO:0042436)4.75297579
7indolalkylamine catabolic process (GO:0046218)4.75297579
8tryptophan catabolic process (GO:0006569)4.75297579
9purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)4.65889361
10positive regulation of vasculogenesis (GO:2001214)4.64008762
11thrombin receptor signaling pathway (GO:0070493)4.29918640
12regulation of memory T cell differentiation (GO:0043380)4.29323612
13negative regulation of alpha-beta T cell differentiation (GO:0046639)4.15580219
14indolalkylamine metabolic process (GO:0006586)4.13148359
15purine deoxyribonucleotide metabolic process (GO:0009151)4.11852669
16definitive hemopoiesis (GO:0060216)4.06845838
17tryptophan metabolic process (GO:0006568)4.05541937
18cellular response to ATP (GO:0071318)3.93194333
19regulation of female gonad development (GO:2000194)3.87110907
20regulation of B cell apoptotic process (GO:0002902)3.85852342
21purine deoxyribonucleotide catabolic process (GO:0009155)3.84347804
22L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.83705547
23regulation of germinal center formation (GO:0002634)3.75329807
24positive regulation of granulocyte differentiation (GO:0030854)3.69622306
25negative regulation of thymocyte apoptotic process (GO:0070244)3.69096942
26protein localization to Golgi apparatus (GO:0034067)3.64794713
27mature B cell differentiation involved in immune response (GO:0002313)3.63283649
28preassembly of GPI anchor in ER membrane (GO:0016254)3.55597508
29negative regulation of B cell apoptotic process (GO:0002903)3.49619755
30purine nucleotide salvage (GO:0032261)3.49144792
31adenosine metabolic process (GO:0046085)3.46287930
32interkinetic nuclear migration (GO:0022027)3.36162996
33Peyers patch development (GO:0048541)3.34159382
34mucosal-associated lymphoid tissue development (GO:0048537)3.34159382
35cell differentiation involved in metanephros development (GO:0072202)3.33182830
36fucose catabolic process (GO:0019317)3.27714485
37L-fucose metabolic process (GO:0042354)3.27714485
38L-fucose catabolic process (GO:0042355)3.27714485
39regulation of vasculogenesis (GO:2001212)3.27451613
40regulation of regulatory T cell differentiation (GO:0045589)3.24508129
41cellular response to exogenous dsRNA (GO:0071360)3.22639260
42L-methionine salvage (GO:0071267)3.21091412
43L-methionine biosynthetic process (GO:0071265)3.21091412
44amino acid salvage (GO:0043102)3.21091412
45response to vitamin E (GO:0033197)3.19305571
46positive regulation of histone H3-K4 methylation (GO:0051571)3.16999657
47regulation of T-helper 1 type immune response (GO:0002825)3.05936068
48parturition (GO:0007567)3.05725615
49C4-dicarboxylate transport (GO:0015740)3.04151316
50deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.03427886
51axoneme assembly (GO:0035082)3.01029237
52regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.99535714
53amino-acid betaine transport (GO:0015838)2.98655804
54carnitine transport (GO:0015879)2.98655804
55positive regulation of defense response to virus by host (GO:0002230)2.96727267
56RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.95573053
57energy homeostasis (GO:0097009)2.93458652
58inositol phosphate dephosphorylation (GO:0046855)2.89510567
59phosphorylated carbohydrate dephosphorylation (GO:0046838)2.89510567
60carnitine transmembrane transport (GO:1902603)2.88130698
61C21-steroid hormone biosynthetic process (GO:0006700)2.85718933
62GMP metabolic process (GO:0046037)2.85568377
63epithelial cell differentiation involved in kidney development (GO:0035850)2.85405582
64cellular biogenic amine catabolic process (GO:0042402)2.82423180
65amine catabolic process (GO:0009310)2.82423180
66indole-containing compound metabolic process (GO:0042430)2.80766748
67negative regulation of cytokine secretion (GO:0050710)2.79836461
68cytochrome complex assembly (GO:0017004)2.79743307
69inositol phosphate catabolic process (GO:0071545)2.78663734
70parental behavior (GO:0060746)2.76180832
71poly(A)+ mRNA export from nucleus (GO:0016973)2.76047724
72positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75507455
73angiogenesis involved in wound healing (GO:0060055)2.73861982
74mature B cell differentiation (GO:0002335)2.70174429
75detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.69651661
76negative regulation of protein oligomerization (GO:0032460)2.68341742
77positive regulation of alpha-beta T cell proliferation (GO:0046641)2.66616418
78histamine secretion (GO:0001821)2.66238615
79B cell mediated immunity (GO:0019724)2.65460926
80benzene-containing compound metabolic process (GO:0042537)2.64858036
81DNA deamination (GO:0045006)2.64152138
82establishment of protein localization to peroxisome (GO:0072663)2.63924256
83protein localization to peroxisome (GO:0072662)2.63924256
84protein targeting to peroxisome (GO:0006625)2.63924256
85negative regulation of alpha-beta T cell activation (GO:0046636)2.62868828
86negative regulation of telomere maintenance (GO:0032205)2.62818240
87nitric oxide mediated signal transduction (GO:0007263)2.62068258
88regulation of T-helper 2 cell differentiation (GO:0045628)2.61808262
89inositol metabolic process (GO:0006020)2.60779214
90positive regulation of steroid hormone secretion (GO:2000833)2.58504631
91aromatic amino acid family catabolic process (GO:0009074)2.58283814
92positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.57872935
93immunoglobulin mediated immune response (GO:0016064)2.57382113
94monoamine transport (GO:0015844)2.55143044
95rRNA catabolic process (GO:0016075)2.54485193
96negative regulation of type 2 immune response (GO:0002829)2.53884574
97aggressive behavior (GO:0002118)2.53480870
98regulation of type B pancreatic cell apoptotic process (GO:2000674)2.51222136
99regulation of collateral sprouting (GO:0048670)2.49076184
100response to pheromone (GO:0019236)2.48955318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.80442215
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.55300071
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse4.52309840
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.90799509
5ZNF274_21170338_ChIP-Seq_K562_Hela2.70622848
6SCL_19346495_ChIP-Seq_HPC-7_Human2.60066336
7GBX2_23144817_ChIP-Seq_PC3_Human2.54869067
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47823297
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42117600
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.35777559
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.34156764
12IGF1R_20145208_ChIP-Seq_DFB_Human2.33749294
13VDR_22108803_ChIP-Seq_LS180_Human2.31568358
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24794860
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15356245
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.10036976
17FUS_26573619_Chip-Seq_HEK293_Human1.78383582
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66345252
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.64355247
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.63765887
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58882228
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54810769
23FOXA1_27270436_Chip-Seq_PROSTATE_Human1.53953410
24FOXA1_25329375_ChIP-Seq_VCAP_Human1.53953410
25CBP_20019798_ChIP-Seq_JUKART_Human1.53570325
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53570325
27RUNX_20019798_ChIP-Seq_JUKART_Human1.51819055
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51344678
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51271285
30TAF15_26573619_Chip-Seq_HEK293_Human1.50859973
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48351993
32FOXA1_21572438_ChIP-Seq_LNCaP_Human1.48034020
33ER_23166858_ChIP-Seq_MCF-7_Human1.47129905
34GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.44614959
35P300_19829295_ChIP-Seq_ESCs_Human1.34562238
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.34264497
37AR_25329375_ChIP-Seq_VCAP_Human1.34240200
38PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.30890484
39SOX2_19829295_ChIP-Seq_ESCs_Human1.30620901
40NANOG_19829295_ChIP-Seq_ESCs_Human1.30620901
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26583780
42GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26387085
43GATA3_26560356_Chip-Seq_TH2_Human1.25944893
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23950259
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23223025
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.23217127
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22565431
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22391993
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22051860
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21628439
51EWS_26573619_Chip-Seq_HEK293_Human1.20931917
52CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20752470
53GATA3_27048872_Chip-Seq_THYMUS_Human1.20026397
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.18828816
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18794786
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17353783
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17039423
58AR_20517297_ChIP-Seq_VCAP_Human1.16599594
59MYB_26560356_Chip-Seq_TH2_Human1.16417634
60TCF4_23295773_ChIP-Seq_U87_Human1.14908088
61NCOR_22424771_ChIP-Seq_293T_Human1.13127718
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12973135
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.11367927
64* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10045020
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09856438
66OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09434845
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07660724
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07035389
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06230532
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05648795
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.05324417
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.05187967
73SMAD4_21799915_ChIP-Seq_A2780_Human1.04493136
74GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.03556632
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03496886
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.03441468
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01665047
78CDX2_22108803_ChIP-Seq_LS180_Human1.01160840
79RUNX2_22187159_ChIP-Seq_PCA_Human1.00722405
80CRX_20693478_ChIP-Seq_RETINA_Mouse0.99119968
81STAT3_23295773_ChIP-Seq_U87_Human0.99096821
82SMAD3_21741376_ChIP-Seq_EPCs_Human0.99002902
83* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97681162
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96656977
85CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96628410
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96169640
87HOXB7_26014856_ChIP-Seq_BT474_Human0.95355570
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.95229615
89* SMAD4_21741376_ChIP-Seq_EPCs_Human0.94837965
90P53_21459846_ChIP-Seq_SAOS-2_Human0.94102131
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94091636
92FOXA1_25552417_ChIP-Seq_VCAP_Human0.93345705
93ELK1_19687146_ChIP-ChIP_HELA_Human0.93025977
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92865843
95IRF8_27001747_Chip-Seq_BMDM_Mouse0.92480945
96P53_22387025_ChIP-Seq_ESCs_Mouse0.91354744
97AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90569357
98TP53_22573176_ChIP-Seq_HFKS_Human0.89495648
99KDM2B_26808549_Chip-Seq_REH_Human0.87560314
100BCAT_22108803_ChIP-Seq_LS180_Human0.86860443

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.71396771
2MP0002396_abnormal_hematopoietic_system3.68844838
3MP0003787_abnormal_imprinting3.65925840
4MP0003195_calcinosis3.27530209
5MP0005646_abnormal_pituitary_gland3.02696375
6MP0004147_increased_porphyrin_level2.72294935
7MP0001835_abnormal_antigen_presentation2.64175100
8MP0009278_abnormal_bone_marrow2.57644455
9MP0006054_spinal_hemorrhage2.52369838
10MP0003806_abnormal_nucleotide_metabolis2.49946570
11MP0005451_abnormal_body_composition2.45975570
12MP0002876_abnormal_thyroid_physiology2.39828964
13MP0001545_abnormal_hematopoietic_system2.17224168
14MP0005397_hematopoietic_system_phenotyp2.17224168
15MP0002837_dystrophic_cardiac_calcinosis2.10001106
16MP0005084_abnormal_gallbladder_morpholo2.07108428
17MP0001188_hyperpigmentation1.83972273
18MP0005085_abnormal_gallbladder_physiolo1.83330528
19MP0006072_abnormal_retinal_apoptosis1.77437289
20MP0005075_abnormal_melanosome_morpholog1.74363169
21MP0002127_abnormal_cardiovascular_syste1.74361487
22MP0005645_abnormal_hypothalamus_physiol1.74316633
23MP0003252_abnormal_bile_duct1.67735317
24MP0003122_maternal_imprinting1.59609360
25MP0001764_abnormal_homeostasis1.50258938
26MP0006036_abnormal_mitochondrial_physio1.48234114
27MP0001727_abnormal_embryo_implantation1.46957683
28MP0000013_abnormal_adipose_tissue1.43552537
29MP0010329_abnormal_lipoprotein_level1.43514255
30MP0008875_abnormal_xenobiotic_pharmacok1.43492867
31MP0008872_abnormal_physiological_respon1.42255763
32MP0002693_abnormal_pancreas_physiology1.41811150
33MP0002909_abnormal_adrenal_gland1.39703942
34MP0005535_abnormal_body_temperature1.38595597
35MP0000631_abnormal_neuroendocrine_gland1.38495373
36MP0003724_increased_susceptibility_to1.37053294
37MP0000678_abnormal_parathyroid_gland1.36085807
38MP0006292_abnormal_olfactory_placode1.34490087
39MP0003172_abnormal_lysosome_physiology1.29534539
40MP0008004_abnormal_stomach_pH1.28842108
41MP0002148_abnormal_hypersensitivity_rea1.28605351
42MP0002928_abnormal_bile_duct1.26504835
43MP0009697_abnormal_copulation1.24549325
44MP0004808_abnormal_hematopoietic_stem1.23813806
45MP0001986_abnormal_taste_sensitivity1.19982970
46MP0005220_abnormal_exocrine_pancreas1.18413818
47MP0000230_abnormal_systemic_arterial1.17069580
48MP0004215_abnormal_myocardial_fiber1.16807639
49MP0005551_abnormal_eye_electrophysiolog1.16758552
50MP0002132_abnormal_respiratory_system1.16298750
51MP0009764_decreased_sensitivity_to1.15795823
52MP0005387_immune_system_phenotype1.13482840
53MP0001790_abnormal_immune_system1.13482840
54MP0005410_abnormal_fertilization1.13263433
55MP0002254_reproductive_system_inflammat1.11270683
56MP0001501_abnormal_sleep_pattern1.06849578
57MP0001944_abnormal_pancreas_morphology1.05758544
58MP0003283_abnormal_digestive_organ1.03665064
59MP0005448_abnormal_energy_balance1.02826039
60MP0003011_delayed_dark_adaptation1.02799378
61MP0001905_abnormal_dopamine_level1.00921583
62MP0003121_genomic_imprinting0.99965774
63MP0005167_abnormal_blood-brain_barrier0.99416162
64MP0003646_muscle_fatigue0.98745065
65MP0004019_abnormal_vitamin_homeostasis0.98016022
66MP0003123_paternal_imprinting0.95853061
67MP0005464_abnormal_platelet_physiology0.94120865
68MP0000681_abnormal_thyroid_gland0.92561803
69MP0003638_abnormal_response/metabolism_0.92479812
70MP0008873_increased_physiological_sensi0.89733346
71MP0005365_abnormal_bile_salt0.89461587
72MP0010386_abnormal_urinary_bladder0.89442197
73MP0005379_endocrine/exocrine_gland_phen0.87824238
74MP0004084_abnormal_cardiac_muscle0.86282216
75MP0010155_abnormal_intestine_physiology0.85936988
76MP0000516_abnormal_urinary_system0.85489441
77MP0005367_renal/urinary_system_phenotyp0.85489441
78MP0005253_abnormal_eye_physiology0.81364450
79MP0001968_abnormal_touch/_nociception0.79232531
80MP0001765_abnormal_ion_homeostasis0.78774140
81MP0000685_abnormal_immune_system0.78037299
82MP0009643_abnormal_urine_homeostasis0.76469068
83MP0009046_muscle_twitch0.76409513
84MP0000015_abnormal_ear_pigmentation0.76348736
85MP0000689_abnormal_spleen_morphology0.75676668
86MP0001191_abnormal_skin_condition0.75221906
87MP0002138_abnormal_hepatobiliary_system0.74946228
88MP0006035_abnormal_mitochondrial_morpho0.74746404
89MP0002933_joint_inflammation0.73247726
90MP0002398_abnormal_bone_marrow0.73128016
91MP0002163_abnormal_gland_morphology0.72568890
92MP0005310_abnormal_salivary_gland0.70158169
93MP0003718_maternal_effect0.69978358
94MP0005636_abnormal_mineral_homeostasis0.69388994
95MP0000639_abnormal_adrenal_gland0.69232770
96MP0004085_abnormal_heartbeat0.68135170
97MP0003045_fibrosis0.67873512
98MP0001800_abnormal_humoral_immune0.67482667
99MP0000465_gastrointestinal_hemorrhage0.67286994
100MP0002723_abnormal_immune_serum0.66687167

Predicted human phenotypes

RankGene SetZ-score
1Metaphyseal dysplasia (HP:0100255)4.91466828
2Hypoglycemic seizures (HP:0002173)4.64210083
3Neonatal respiratory distress (HP:0002643)3.80891387
4Stomach cancer (HP:0012126)3.71059824
5Hypoglycemic coma (HP:0001325)3.70551870
6Symptomatic seizures (HP:0011145)3.51671047
7Abnormal delayed hypersensitivity skin test (HP:0002963)3.27176936
8Abnormality of the costochondral junction (HP:0000919)3.25056382
9Elevated erythrocyte sedimentation rate (HP:0003565)3.23025104
10Abnormality of the periventricular white matter (HP:0002518)3.21529209
11Abnormality of B cell number (HP:0010975)3.17502463
12Progressive microcephaly (HP:0000253)3.05283108
13Mesangial abnormality (HP:0001966)3.01107671
14Abnormal drinking behavior (HP:0030082)3.00768411
15Polydipsia (HP:0001959)3.00768411
16Facial diplegia (HP:0001349)2.92049228
17Neoplasm of the adrenal cortex (HP:0100641)2.91586287
18Attenuation of retinal blood vessels (HP:0007843)2.89528535
19Pancreatic cysts (HP:0001737)2.85331511
20Stomatitis (HP:0010280)2.79156253
21Severe muscular hypotonia (HP:0006829)2.79093324
22Brushfield spots (HP:0001088)2.77627049
23Congenital stationary night blindness (HP:0007642)2.75217749
24Abnormality of the renal cortex (HP:0011035)2.69489023
25Panhypogammaglobulinemia (HP:0003139)2.68488382
26Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.58352322
27Progressive inability to walk (HP:0002505)2.55951702
28B lymphocytopenia (HP:0010976)2.54416588
29Enlarged epiphyses (HP:0010580)2.51416811
30Hyperinsulinemic hypoglycemia (HP:0000825)2.51304248
31Polyuria (HP:0000103)2.49434225
32Acute lymphatic leukemia (HP:0006721)2.48413201
33Ketoacidosis (HP:0001993)2.37320018
34Adrenal hypoplasia (HP:0000835)2.21759539
35Abnormal rod and cone electroretinograms (HP:0008323)2.20447189
36Intellectual disability, profound (HP:0002187)2.19348639
37Medial flaring of the eyebrow (HP:0010747)2.18660344
38Tubular atrophy (HP:0000092)2.16897247
39Decreased circulating renin level (HP:0003351)2.15101838
40Acute myeloid leukemia (HP:0004808)2.15054379
41Agammaglobulinemia (HP:0004432)2.14478831
42Abolished electroretinogram (ERG) (HP:0000550)2.12955973
43Hepatic necrosis (HP:0002605)2.10558204
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10197476
45Pancreatic fibrosis (HP:0100732)2.09357744
46Hyperphosphatemia (HP:0002905)2.08858945
47Keratoconus (HP:0000563)2.07879608
48Increased corneal curvature (HP:0100692)2.07879608
49Abnormality of renal excretion (HP:0011036)2.06994005
50Decreased central vision (HP:0007663)2.06018764
51Limb hypertonia (HP:0002509)2.05410822
52Autoimmune thrombocytopenia (HP:0001973)2.03730303
53Abnormality of the phalanges of the 2nd finger (HP:0009541)2.03691863
54Abnormality of calcium-phosphate metabolism (HP:0100530)2.02703074
55Generalized aminoaciduria (HP:0002909)2.02201144
56Thyroiditis (HP:0100646)1.98367843
57Abnormal pancreas size (HP:0012094)1.97623774
58Abnormal urine output (HP:0012590)1.95871020
59Aplasia/Hypoplasia of the spleen (HP:0010451)1.91968999
60Tachypnea (HP:0002789)1.90766162
61Hypoproteinemia (HP:0003075)1.90004075
62Enlarged penis (HP:0000040)1.89465111
63Hyperglycemia (HP:0003074)1.88113094
64Myositis (HP:0100614)1.87504251
65Dicarboxylic aciduria (HP:0003215)1.86700625
66Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86700625
67Papilledema (HP:0001085)1.85713667
68Cystic liver disease (HP:0006706)1.83226816
69Type 2 muscle fiber atrophy (HP:0003554)1.82692146
70Abnormality of T cell physiology (HP:0011840)1.82626477
71Renal cortical cysts (HP:0000803)1.82260236
72Abnormality of the pubic bones (HP:0003172)1.81549586
73Asplenia (HP:0001746)1.80243784
74Poor speech (HP:0002465)1.78537453
75Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76076524
76Abnormality of macular pigmentation (HP:0008002)1.75745078
77Macroorchidism (HP:0000053)1.74864190
78Disproportionate short-trunk short stature (HP:0003521)1.74545050
79Abnormality of the renal medulla (HP:0100957)1.74473737
80Abnormality of endocrine pancreas physiology (HP:0012093)1.73610584
81Abnormality of the pancreatic islet cells (HP:0006476)1.73610584
82Thrombocytosis (HP:0001894)1.73585481
83Nephronophthisis (HP:0000090)1.72257695
84Abnormality of dental color (HP:0011073)1.70738878
85Dynein arm defect of respiratory motile cilia (HP:0012255)1.70275899
86Absent/shortened dynein arms (HP:0200106)1.70275899
87Clonus (HP:0002169)1.70007710
88Type II lissencephaly (HP:0007260)1.69852388
89Poor eye contact (HP:0000817)1.69536322
90Ketosis (HP:0001946)1.68239144
91Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.67126642
92Spastic paraparesis (HP:0002313)1.66617277
93Alveolar cell carcinoma (HP:0006519)1.66515900
94Congenital primary aphakia (HP:0007707)1.66456971
95Submucous cleft hard palate (HP:0000176)1.65444055
96Abnormal epiphyseal ossification (HP:0010656)1.65295815
97Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64826829
98Agitation (HP:0000713)1.64482091
99Thin bony cortex (HP:0002753)1.63427396
100Inability to walk (HP:0002540)1.62721582

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK5.25405683
2FRK4.30124065
3AKT34.04661046
4TAOK33.28329270
5MAPKAPK33.23804624
6KIT3.04474508
7FLT32.90933476
8TIE12.66425313
9ADRBK22.19615066
10MAP4K22.12299862
11CCNB12.05002089
12PINK12.00392558
13BMPR21.93276445
14NUAK11.90237722
15DYRK31.86736187
16TEC1.73811540
17MAP4K11.68253480
18JAK31.64129959
19INSRR1.58884663
20RIPK41.56389151
21GRK11.50308831
22MKNK21.46410931
23CSF1R1.41145188
24DAPK21.40735304
25BMPR1B1.32678073
26PIK3CG1.29771978
27CSNK1G31.28436379
28EIF2AK31.25650677
29MAP3K41.22155199
30KDR1.20970177
31ITK1.20598440
32ACVR1B1.17714123
33CSNK1G11.14498729
34CDC71.05332411
35MKNK11.05106368
36DAPK11.00158229
37SYK0.99457745
38CSNK1A1L0.95425021
39CSNK1G20.94864261
40HIPK20.93482628
41PTK2B0.93185637
42TLK10.91914691
43BLK0.90333131
44PASK0.90012722
45SGK20.89779564
46MAPK130.86791698
47BCKDK0.83393520
48BRAF0.79257020
49MAP2K70.77668422
50OXSR10.76230817
51MAP3K60.74100305
52SCYL20.72821681
53TNK20.71555078
54NTRK30.69909020
55FES0.69373294
56PRKG20.68974975
57MAP3K20.68922686
58PRKCQ0.68128960
59TNIK0.67371121
60PRKCE0.66597295
61PHKG20.65980164
62PHKG10.65980164
63TRPM70.64375536
64LCK0.63514363
65MAP2K60.61777388
66GRK60.56868401
67VRK20.56405116
68IKBKB0.55885805
69TGFBR10.55489991
70LYN0.53753794
71TBK10.52657786
72BTK0.51445126
73FER0.50893126
74IKBKE0.50285656
75STK390.47366855
76ADRBK10.47093880
77WNK30.46850748
78PLK40.43795108
79CLK10.43428805
80SGK2230.43130592
81SGK4940.43130592
82MAP3K140.40771169
83TTK0.39731973
84PIM10.39447015
85SGK30.37713499
86TXK0.37657429
87MAP2K40.35792835
88FGFR20.35061428
89NLK0.34575865
90PLK30.34239412
91PRKD30.33068504
92PRKAA20.30963885
93MATK0.30753682
94CSNK1A10.30241166
95PLK20.29330136
96IRAK10.29139652
97IGF1R0.28052508
98ABL10.27725204
99PRKCA0.27412798
100RPS6KA50.27161875

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004504.66420977
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.83324776
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.37218524
4Asthma_Homo sapiens_hsa053103.26452001
5Type I diabetes mellitus_Homo sapiens_hsa049402.88654957
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.86192363
7Sulfur metabolism_Homo sapiens_hsa009202.74597838
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34874679
9Tryptophan metabolism_Homo sapiens_hsa003802.30563249
10Allograft rejection_Homo sapiens_hsa053302.29872058
11Butanoate metabolism_Homo sapiens_hsa006502.20128168
12Autoimmune thyroid disease_Homo sapiens_hsa053202.08243867
13Graft-versus-host disease_Homo sapiens_hsa053321.94398135
14Regulation of autophagy_Homo sapiens_hsa041401.92706135
15Phototransduction_Homo sapiens_hsa047441.59051606
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54851619
17Homologous recombination_Homo sapiens_hsa034401.54251589
18Linoleic acid metabolism_Homo sapiens_hsa005911.43089903
19Base excision repair_Homo sapiens_hsa034101.39665414
20Insulin secretion_Homo sapiens_hsa049111.38116964
21Primary immunodeficiency_Homo sapiens_hsa053401.36750047
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34191477
23Staphylococcus aureus infection_Homo sapiens_hsa051501.33603426
24Antigen processing and presentation_Homo sapiens_hsa046121.29580707
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28439823
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25021804
27Sphingolipid metabolism_Homo sapiens_hsa006001.24882527
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23144420
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.19129339
30Ether lipid metabolism_Homo sapiens_hsa005651.17471898
31ABC transporters_Homo sapiens_hsa020101.09250337
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05696555
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01556895
34Leishmaniasis_Homo sapiens_hsa051400.99954944
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99357976
36African trypanosomiasis_Homo sapiens_hsa051430.99074566
37Dorso-ventral axis formation_Homo sapiens_hsa043200.97462106
38Serotonergic synapse_Homo sapiens_hsa047260.96891296
39Circadian entrainment_Homo sapiens_hsa047130.96598068
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95694566
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94599347
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94514282
43Rheumatoid arthritis_Homo sapiens_hsa053230.92182287
44Arachidonic acid metabolism_Homo sapiens_hsa005900.88894845
45Glycerolipid metabolism_Homo sapiens_hsa005610.88136341
46Nitrogen metabolism_Homo sapiens_hsa009100.87913245
47Long-term depression_Homo sapiens_hsa047300.86462618
48Taste transduction_Homo sapiens_hsa047420.85681362
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85208044
50Protein export_Homo sapiens_hsa030600.85125383
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.84434803
52Chemical carcinogenesis_Homo sapiens_hsa052040.84068583
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82796473
54Caffeine metabolism_Homo sapiens_hsa002320.80417760
55Hematopoietic cell lineage_Homo sapiens_hsa046400.79576704
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78989503
57Pancreatic secretion_Homo sapiens_hsa049720.78818927
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77742431
59Platelet activation_Homo sapiens_hsa046110.75548656
60Fatty acid elongation_Homo sapiens_hsa000620.74531661
61Ovarian steroidogenesis_Homo sapiens_hsa049130.72827204
62Renin secretion_Homo sapiens_hsa049240.71673688
63Salivary secretion_Homo sapiens_hsa049700.70423968
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68832399
65Peroxisome_Homo sapiens_hsa041460.67472031
66Fatty acid degradation_Homo sapiens_hsa000710.65799528
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64695694
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63973091
69Tuberculosis_Homo sapiens_hsa051520.62871474
70Purine metabolism_Homo sapiens_hsa002300.62777490
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.61739301
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.60703733
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60367354
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.58775971
75Herpes simplex infection_Homo sapiens_hsa051680.57663674
76Other glycan degradation_Homo sapiens_hsa005110.56071696
77Morphine addiction_Homo sapiens_hsa050320.55694311
78Propanoate metabolism_Homo sapiens_hsa006400.54388864
79Olfactory transduction_Homo sapiens_hsa047400.53543838
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.51400136
81Non-homologous end-joining_Homo sapiens_hsa034500.51173097
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49899376
83Calcium signaling pathway_Homo sapiens_hsa040200.47645670
84Lysosome_Homo sapiens_hsa041420.47443449
85Toxoplasmosis_Homo sapiens_hsa051450.46448771
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.45668148
87Fatty acid metabolism_Homo sapiens_hsa012120.43814621
88Fat digestion and absorption_Homo sapiens_hsa049750.39311084
89RNA degradation_Homo sapiens_hsa030180.38580000
90Retinol metabolism_Homo sapiens_hsa008300.37959631
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36166251
92Proteasome_Homo sapiens_hsa030500.36007312
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34194794
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33393011
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33196438
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.27381501
97Metabolic pathways_Homo sapiens_hsa011000.27258724
98Systemic lupus erythematosus_Homo sapiens_hsa053220.26013056
99Dopaminergic synapse_Homo sapiens_hsa047280.24852856
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24079317

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