KCNK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular potassium ion homeostasis (GO:0030007)5.52837911
2sodium ion export (GO:0071436)4.98038296
3gonadal mesoderm development (GO:0007506)4.79677400
4negative regulation of dendrite morphogenesis (GO:0050774)4.70283987
5locomotory exploration behavior (GO:0035641)4.66862915
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.65051913
7synaptic vesicle exocytosis (GO:0016079)4.52243467
8chemosensory behavior (GO:0007635)4.45409136
9righting reflex (GO:0060013)4.36628729
10glutamate secretion (GO:0014047)4.34608120
11cytoskeletal anchoring at plasma membrane (GO:0007016)4.33414493
12neuronal ion channel clustering (GO:0045161)4.14484624
13vocalization behavior (GO:0071625)4.13717309
14synaptic vesicle maturation (GO:0016188)4.10636968
15dendritic spine morphogenesis (GO:0060997)4.06084480
16thyroid hormone generation (GO:0006590)4.04812496
17cell communication by electrical coupling (GO:0010644)4.03343780
18activation of protein kinase A activity (GO:0034199)4.02833236
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.02765585
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.94536821
21neuronal action potential propagation (GO:0019227)3.92034659
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.90756955
23positive regulation of protein sumoylation (GO:0033235)3.84535714
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.84391756
25neurotransmitter-gated ion channel clustering (GO:0072578)3.83759720
26cellular sodium ion homeostasis (GO:0006883)3.79082743
27regulation of synaptic vesicle exocytosis (GO:2000300)3.77749288
28C4-dicarboxylate transport (GO:0015740)3.77546800
29positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.74861533
30synaptic transmission, glutamatergic (GO:0035249)3.74454159
31glutamate receptor signaling pathway (GO:0007215)3.73700288
32regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.73262930
33synaptic vesicle docking involved in exocytosis (GO:0016081)3.73035718
34potassium ion homeostasis (GO:0055075)3.73000634
35dendritic spine organization (GO:0097061)3.70014816
36gamma-aminobutyric acid transport (GO:0015812)3.68315589
37neurotransmitter secretion (GO:0007269)3.67340169
38potassium ion import (GO:0010107)3.66030942
39amino acid import (GO:0043090)3.57694717
40thyroid hormone metabolic process (GO:0042403)3.56655884
41L-amino acid import (GO:0043092)3.56488068
42negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.55467103
43protein K11-linked deubiquitination (GO:0035871)3.51389204
44G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.49058028
45regulation of glutamate receptor signaling pathway (GO:1900449)3.48866214
46detection of calcium ion (GO:0005513)3.48646987
47neuron-neuron synaptic transmission (GO:0007270)3.47314896
48desmosome organization (GO:0002934)3.45403314
49alanine transport (GO:0032328)3.39456997
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.39039359
51regulation of synaptic vesicle transport (GO:1902803)3.36577249
52cerebellar granule cell differentiation (GO:0021707)3.35684670
53negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35240273
54response to histamine (GO:0034776)3.34849502
55neuromuscular process controlling posture (GO:0050884)3.34803993
56membrane repolarization (GO:0086009)3.32754678
57exploration behavior (GO:0035640)3.32070775
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30058918
59cerebellar Purkinje cell layer development (GO:0021680)3.29269996
60regulation of neuronal synaptic plasticity (GO:0048168)3.28868576
61response to auditory stimulus (GO:0010996)3.27856262
62long-term synaptic potentiation (GO:0060291)3.27584256
63proline transport (GO:0015824)3.24684615
64protein localization to synapse (GO:0035418)3.23858459
65regulation of beta-amyloid formation (GO:1902003)3.22518477
66long-term memory (GO:0007616)3.20323787
67regulation of cell communication by electrical coupling (GO:0010649)3.20304478
68positive regulation of synapse maturation (GO:0090129)3.19874516
69regulation of long-term neuronal synaptic plasticity (GO:0048169)3.18876684
70layer formation in cerebral cortex (GO:0021819)3.18537933
71detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.16678716
72L-serine transport (GO:0015825)3.16619787
73neurotransmitter transport (GO:0006836)3.12481385
74regulation of heart rate by cardiac conduction (GO:0086091)3.12386525
75regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.10466647
76transmission of nerve impulse (GO:0019226)3.09613419
77positive regulation of dendritic spine development (GO:0060999)3.08579723
78regulation of synapse structural plasticity (GO:0051823)3.07777380
79positive regulation of potassium ion transmembrane transport (GO:1901381)3.07154198
80membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.07036049
81neuron cell-cell adhesion (GO:0007158)3.00388860
82regulation of synaptic plasticity (GO:0048167)2.99912779
83auditory behavior (GO:0031223)2.96690339
84central nervous system myelination (GO:0022010)2.95630456
85axon ensheathment in central nervous system (GO:0032291)2.95630456
86cardiac conduction (GO:0061337)2.95551446
87tooth mineralization (GO:0034505)2.94303167
88cerebellar Purkinje cell differentiation (GO:0021702)2.93789185
89regulation of dendritic spine morphogenesis (GO:0061001)2.92338787
90membrane repolarization during action potential (GO:0086011)2.92015358
91negative regulation of hormone biosynthetic process (GO:0032353)2.91616227
92negative regulation of hormone metabolic process (GO:0032351)2.91616227
93long term synaptic depression (GO:0060292)2.91019267
94regulation of protein sumoylation (GO:0033233)2.89688255
95regulation of amyloid precursor protein catabolic process (GO:1902991)2.89339087
96cAMP biosynthetic process (GO:0006171)2.88060898
97regulation of synaptic transmission, glutamatergic (GO:0051966)2.86786547
98positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.85447308
99ATP hydrolysis coupled proton transport (GO:0015991)2.85266939
100energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.85266939
101regulation of neurotransmitter levels (GO:0001505)2.84932010
102regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.84918908
103regulation of vesicle fusion (GO:0031338)2.84003380
104acid secretion (GO:0046717)2.83821190
105regulation of excitatory postsynaptic membrane potential (GO:0060079)2.80862454
106positive regulation of potassium ion transport (GO:0043268)2.79812039
107regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.78494803
108neuromuscular process controlling balance (GO:0050885)2.76748032
109positive regulation of protein targeting to membrane (GO:0090314)2.76596328
110glycine transport (GO:0015816)2.75488099
111neurotransmitter uptake (GO:0001504)2.73323206
112* potassium ion transmembrane transport (GO:0071805)2.73264318
113* cellular potassium ion transport (GO:0071804)2.73264318
114negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.72864849
115regulation of dendritic spine development (GO:0060998)2.72660886
116innervation (GO:0060384)2.72315143
117synapse assembly (GO:0007416)2.71887535
118response to dietary excess (GO:0002021)2.71539798
119regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.70228669
120cell communication involved in cardiac conduction (GO:0086065)2.70136338
121membrane hyperpolarization (GO:0060081)2.69642365
122regulation of postsynaptic membrane potential (GO:0060078)2.69332968
123myelin maintenance (GO:0043217)2.68837622
124positive regulation of neurotransmitter transport (GO:0051590)2.68247393
125positive regulation of neurotransmitter secretion (GO:0001956)2.67609424
126sodium ion homeostasis (GO:0055078)2.67579138
127synaptic vesicle endocytosis (GO:0048488)2.67174349
128regulation of neurotransmitter transport (GO:0051588)2.66601634
129positive regulation of sodium ion transport (GO:0010765)2.65928655
130cellular response to glucagon stimulus (GO:0071377)2.65339564
131cochlea development (GO:0090102)2.64243222
132* synaptic transmission (GO:0007268)2.63999027
133bundle of His cell to Purkinje myocyte communication (GO:0086069)2.63886880
134regulation of voltage-gated calcium channel activity (GO:1901385)2.63609266
135signal release (GO:0023061)2.62195156
136regulation of synapse maturation (GO:0090128)2.61555681
137negative regulation of sodium ion transport (GO:0010766)2.61456735
138regulation of calcium ion-dependent exocytosis (GO:0017158)2.61388205
139negative regulation of dendrite development (GO:2000171)2.60330810
140positive regulation of membrane potential (GO:0045838)2.60036949
141dendrite morphogenesis (GO:0048813)2.59470259
142serine transport (GO:0032329)2.58781770
143mechanosensory behavior (GO:0007638)2.56726600
144regulation of neurotransmitter secretion (GO:0046928)2.56337858
145positive regulation of sodium ion transmembrane transport (GO:1902307)2.55918686
146negative regulation of astrocyte differentiation (GO:0048712)2.55714464
147acidic amino acid transport (GO:0015800)2.52947559

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.48047851
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.61267641
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16608447
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.13047393
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03477885
6GBX2_23144817_ChIP-Seq_PC3_Human2.99557354
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73824587
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.72592275
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63605205
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59029914
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59029914
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58541815
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55244016
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52739673
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51640976
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45815284
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43741186
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.35238880
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.33299662
20DROSHA_22980978_ChIP-Seq_HELA_Human2.32656292
21* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.32422311
22REST_21632747_ChIP-Seq_MESCs_Mouse2.27490394
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.20881366
24ESR1_21235772_ChIP-Seq_MCF-7_Human2.16154101
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.11606487
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.10047048
27* RNF2_27304074_Chip-Seq_ESCs_Mouse2.08628694
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07277158
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06433256
30AR_21572438_ChIP-Seq_LNCaP_Human2.02479751
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.97496605
32* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.96600362
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.85494909
34ZNF263_19887448_ChIP-Seq_K562_Human1.80233217
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69069384
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65851262
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63782860
38* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55198049
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53174097
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.48829480
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47837132
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44855739
43SMAD4_21799915_ChIP-Seq_A2780_Human1.42707161
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39795227
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38545497
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37241763
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36132999
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.33375684
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31855276
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31555077
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.30150621
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29458678
53CDX2_20551321_ChIP-Seq_CACO-2_Human1.28167666
54* ESR2_21235772_ChIP-Seq_MCF-7_Human1.27637878
55* AR_25329375_ChIP-Seq_VCAP_Human1.26851024
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26834178
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25762402
58AHR_22903824_ChIP-Seq_MCF-7_Human1.25666966
59* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25138372
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21929255
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20666136
62* AR_19668381_ChIP-Seq_PC3_Human1.20427262
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19373722
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18876787
65RXR_22108803_ChIP-Seq_LS180_Human1.17243471
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15948334
67P300_19829295_ChIP-Seq_ESCs_Human1.15146120
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14897586
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13958502
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.12860759
71* SOX2_21211035_ChIP-Seq_LN229_Gbm1.12499009
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11550743
73* GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.11093075
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.10440377
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09919322
76* SOX2_20726797_ChIP-Seq_SW620_Human1.09789499
77* RACK7_27058665_Chip-Seq_MCF-7_Human1.09641127
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09623470
79* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08062174
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.08061234
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07335914
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04880771
83SMAD3_21741376_ChIP-Seq_HESCs_Human1.04401731
84* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03694741
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03651650
86ZNF274_21170338_ChIP-Seq_K562_Hela1.03646777
87STAT3_23295773_ChIP-Seq_U87_Human1.03271332
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.03113991
89* CTCF_27219007_Chip-Seq_Bcells_Human1.02358045
90BCAT_22108803_ChIP-Seq_LS180_Human1.01602756
91SMAD4_21741376_ChIP-Seq_HESCs_Human1.00714737
92HTT_18923047_ChIP-ChIP_STHdh_Human1.00298513
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97272072
94* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96593575
95* KDM2B_26808549_Chip-Seq_K562_Human0.96037109
96* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95720805
97* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95652029
98ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95082714
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94347435
100* TP53_18474530_ChIP-ChIP_U2OS_Human0.94197176
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92917288
102ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.92350534
103SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91777190
104SMAD3_21741376_ChIP-Seq_ESCs_Human0.91415872
105ESR1_20079471_ChIP-ChIP_T-47D_Human0.91351976
106RUNX2_22187159_ChIP-Seq_PCA_Human0.90976887
107PRDM14_20953172_ChIP-Seq_ESCs_Human0.90912327
108SOX2_18555785_Chip-Seq_ESCs_Mouse0.90604532
109* TP53_16413492_ChIP-PET_HCT116_Human0.90591407
110TAF15_26573619_Chip-Seq_HEK293_Human0.90398156
111* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90273729
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90254006
113ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90209032
114RUNX1_27514584_Chip-Seq_MCF-7_Human0.89481724
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88915840
116* TCF4_23295773_ChIP-Seq_U87_Human0.88503648
117P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88133850
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86907039
119TP53_20018659_ChIP-ChIP_R1E_Mouse0.86884462
120SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86299057
121* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86148178
122KLF5_25053715_ChIP-Seq_YYC3_Human0.86028722
123ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85630424
124* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84807634
125CREB1_26743006_Chip-Seq_LNCaP_Human0.84770494
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84550029
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84492471
128* TET1_21490601_ChIP-Seq_MESCs_Mouse0.83240732
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81772647
130TRIM28_21343339_ChIP-Seq_HEK293_Human0.81269764
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81232053
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.80348328
133NANOG_18555785_Chip-Seq_ESCs_Mouse0.79655858
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79487175
135RNF2_27304074_Chip-Seq_NSC_Mouse0.78353083
136CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77864773
137HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.76850346
138VDR_22108803_ChIP-Seq_LS180_Human0.75199559
139* GATA3_24758297_ChIP-Seq_MCF-7_Human0.74895352
140FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73398086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.93627261
2MP0003635_abnormal_synaptic_transmissio3.42830517
3MP0003880_abnormal_central_pattern3.19701861
4MP0004270_analgesia2.95401832
5MP0009745_abnormal_behavioral_response2.87861892
6MP0009046_muscle_twitch2.76501855
7MP0004885_abnormal_endolymph2.75908084
8MP0002064_seizures2.69961000
9MP0002063_abnormal_learning/memory/cond2.68763517
10MP0004043_abnormal_pH_regulation2.65590013
11MP0001486_abnormal_startle_reflex2.47863167
12MP0009780_abnormal_chondrocyte_physiolo2.44577690
13MP0003329_amyloid_beta_deposits2.39237219
14MP0002572_abnormal_emotion/affect_behav2.38976291
15MP0001968_abnormal_touch/_nociception2.38795961
16MP0002272_abnormal_nervous_system2.24289902
17MP0002734_abnormal_mechanical_nocicepti2.23006911
18MP0000579_abnormal_nail_morphology2.20763722
19MP0004858_abnormal_nervous_system2.20525107
20MP0001440_abnormal_grooming_behavior2.20061193
21MP0005646_abnormal_pituitary_gland2.13682023
22MP0002736_abnormal_nociception_after2.12241503
23MP0002909_abnormal_adrenal_gland2.09079907
24MP0001501_abnormal_sleep_pattern2.07323758
25MP0008569_lethality_at_weaning1.95360726
26MP0003123_paternal_imprinting1.90254369
27MP0002067_abnormal_sensory_capabilities1.87018766
28MP0010234_abnormal_vibrissa_follicle1.82651302
29MP0001502_abnormal_circadian_rhythm1.82027758
30MP0002733_abnormal_thermal_nociception1.81897714
31MP0002735_abnormal_chemical_nociception1.81576404
32MP0005084_abnormal_gallbladder_morpholo1.73240492
33MP0002557_abnormal_social/conspecific_i1.71189980
34MP0002796_impaired_skin_barrier1.67240794
35MP0002822_catalepsy1.66563303
36MP0001970_abnormal_pain_threshold1.64703642
37MP0005423_abnormal_somatic_nervous1.58952549
38MP0001984_abnormal_olfaction1.58085708
39MP0001485_abnormal_pinna_reflex1.53783790
40MP0003690_abnormal_glial_cell1.47176762
41MP0003879_abnormal_hair_cell1.41310490
42MP0010386_abnormal_urinary_bladder1.40748753
43MP0001664_abnormal_digestion1.38686625
44MP0000003_abnormal_adipose_tissue1.38266428
45MP0004924_abnormal_behavior1.37833843
46MP0005386_behavior/neurological_phenoty1.37833843
47MP0003633_abnormal_nervous_system1.37220248
48MP0000566_synostosis1.37003946
49MP0002184_abnormal_innervation1.33984293
50MP0003183_abnormal_peptide_metabolism1.32465004
51MP0004147_increased_porphyrin_level1.29499221
52MP0002254_reproductive_system_inflammat1.29273933
53MP0010678_abnormal_skin_adnexa1.28494688
54MP0000778_abnormal_nervous_system1.28236462
55MP0005377_hearing/vestibular/ear_phenot1.27952536
56MP0003878_abnormal_ear_physiology1.27952536
57MP0001765_abnormal_ion_homeostasis1.27180115
58MP0000955_abnormal_spinal_cord1.22561067
59MP0002066_abnormal_motor_capabilities/c1.19156491
60MP0002882_abnormal_neuron_morphology1.18620997
61MP0003941_abnormal_skin_development1.16263757
62MP0001944_abnormal_pancreas_morphology1.15325090
63MP0003631_nervous_system_phenotype1.14255035
64MP0004019_abnormal_vitamin_homeostasis1.10368344
65MP0004811_abnormal_neuron_physiology1.09752095
66MP0004742_abnormal_vestibular_system1.09731417
67MP0000920_abnormal_myelination1.09519841
68MP0000681_abnormal_thyroid_gland1.09047490
69MP0000604_amyloidosis1.08441713
70MP0002876_abnormal_thyroid_physiology1.06943864
71MP0003075_altered_response_to1.05818211
72MP0008872_abnormal_physiological_respon1.04452284
73MP0000013_abnormal_adipose_tissue1.03911308
74MP0000462_abnormal_digestive_system1.03560349
75MP0001963_abnormal_hearing_physiology1.03531093
76MP0003634_abnormal_glial_cell1.03282695
77MP0005551_abnormal_eye_electrophysiolog0.99021375
78MP0003632_abnormal_nervous_system0.96453089
79MP0003283_abnormal_digestive_organ0.96388254
80MP0002152_abnormal_brain_morphology0.95756841
81MP0002229_neurodegeneration0.94934471
82MP0004142_abnormal_muscle_tone0.93205877
83MP0001177_atelectasis0.93030724
84MP0002069_abnormal_eating/drinking_beha0.91540065
85MP0005645_abnormal_hypothalamus_physiol0.89693299
86MP0008875_abnormal_xenobiotic_pharmacok0.88752087
87MP0005501_abnormal_skin_physiology0.88531874
88MP0000678_abnormal_parathyroid_gland0.87843280
89MP0001348_abnormal_lacrimal_gland0.87231103
90MP0006072_abnormal_retinal_apoptosis0.86996464
91MP0010771_integument_phenotype0.84907304
92MP0004264_abnormal_extraembryonic_tissu0.84610775
93MP0005623_abnormal_meninges_morphology0.82065872
94MP0008004_abnormal_stomach_pH0.81366076
95MP0001881_abnormal_mammary_gland0.81298305
96MP0005448_abnormal_energy_balance0.81089427
97MP0000537_abnormal_urethra_morphology0.80754426
98MP0001299_abnormal_eye_distance/0.80697345
99MP0000631_abnormal_neuroendocrine_gland0.80523686
100MP0001346_abnormal_lacrimal_gland0.80216308
101MP0003787_abnormal_imprinting0.79855975
102MP0002090_abnormal_vision0.79814643
103MP0004215_abnormal_myocardial_fiber0.79326275
104MP0000026_abnormal_inner_ear0.77148490
105MP0005332_abnormal_amino_acid0.74867320
106MP0000762_abnormal_tongue_morphology0.74538822
107MP0005499_abnormal_olfactory_system0.73674745
108MP0005394_taste/olfaction_phenotype0.73674745
109MP0003137_abnormal_impulse_conducting0.73478472
110MP0005379_endocrine/exocrine_gland_phen0.72676841
111MP0001188_hyperpigmentation0.72367489
112MP0001905_abnormal_dopamine_level0.71940032
113MP0002638_abnormal_pupillary_reflex0.71062626
114MP0000534_abnormal_ureter_morphology0.71009148
115MP0002089_abnormal_postnatal_growth/wei0.70619662
116MP0002653_abnormal_ependyma_morphology0.69955172
117MP0003122_maternal_imprinting0.69859338
118MP0008874_decreased_physiological_sensi0.69837010
119MP0005220_abnormal_exocrine_pancreas0.66602136
120MP0002234_abnormal_pharynx_morphology0.66463591
121MP0002752_abnormal_somatic_nervous0.65904952
122MP0005535_abnormal_body_temperature0.65681961
123MP0004133_heterotaxia0.65527014
124MP0002693_abnormal_pancreas_physiology0.65242734
125MP0008961_abnormal_basal_metabolism0.65020739
126MP0005165_increased_susceptibility_to0.64129038
127MP0003953_abnormal_hormone_level0.63717493
128MP0004145_abnormal_muscle_electrophysio0.63362606
129MP0002078_abnormal_glucose_homeostasis0.63066340
130MP0003638_abnormal_response/metabolism_0.62521380
131MP0002160_abnormal_reproductive_system0.61040218
132MP0002098_abnormal_vibrissa_morphology0.60146111
133MP0001756_abnormal_urination0.59255210

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.23622668
2Myokymia (HP:0002411)4.70181023
3Epileptic encephalopathy (HP:0200134)4.29511124
4Focal seizures (HP:0007359)4.05563985
5Visual hallucinations (HP:0002367)3.88963616
6Megalencephaly (HP:0001355)3.81805854
7Aplasia involving bones of the extremities (HP:0009825)3.76232498
8Aplasia involving bones of the upper limbs (HP:0009823)3.76232498
9Aplasia of the phalanges of the hand (HP:0009802)3.76232498
10Atonic seizures (HP:0010819)3.75884550
11Action tremor (HP:0002345)3.56620356
12Febrile seizures (HP:0002373)3.43782229
13Progressive cerebellar ataxia (HP:0002073)3.35247450
14Absence seizures (HP:0002121)3.20672398
15Metabolic alkalosis (HP:0200114)3.19091064
16Hemiplegia (HP:0002301)3.15361561
17Onycholysis (HP:0001806)3.10707356
18Hemiparesis (HP:0001269)3.09751206
19Increased circulating renin level (HP:0000848)3.06701849
20Hyperactive renin-angiotensin system (HP:0000841)3.05911158
21Abnormality of aromatic amino acid family metabolism (HP:0004338)3.00447340
22Generalized tonic-clonic seizures (HP:0002069)2.91311290
23Neurofibrillary tangles (HP:0002185)2.87460740
24Cerebral hypomyelination (HP:0006808)2.86044797
25Dialeptic seizures (HP:0011146)2.84184039
26Diplopia (HP:0000651)2.80623433
27Abnormality of binocular vision (HP:0011514)2.80623433
28Goiter (HP:0000853)2.77625311
29Hypokalemic alkalosis (HP:0001949)2.75905974
30Tetraplegia (HP:0002445)2.75336479
31Status epilepticus (HP:0002133)2.72286423
32Scanning speech (HP:0002168)2.71629000
33Dysdiadochokinesis (HP:0002075)2.68025968
34Right ventricular cardiomyopathy (HP:0011663)2.67935900
35Torticollis (HP:0000473)2.66891368
36Hyperventilation (HP:0002883)2.66207893
37Cerebral inclusion bodies (HP:0100314)2.64621326
38Abnormality of the dental pulp (HP:0006479)2.63411804
39Focal dystonia (HP:0004373)2.59175289
40Hyperaldosteronism (HP:0000859)2.58505876
41Truncal ataxia (HP:0002078)2.55443030
42Abnormality of renal excretion (HP:0011036)2.55229118
43Supranuclear gaze palsy (HP:0000605)2.55014364
44Abnormal eating behavior (HP:0100738)2.52348330
45Abnormal urine output (HP:0012590)2.48450788
46Gout (HP:0001997)2.44699234
47Gaze-evoked nystagmus (HP:0000640)2.42835135
48Pili torti (HP:0003777)2.41175793
49Anxiety (HP:0000739)2.37267755
50Abnormality of cochlea (HP:0000375)2.37033291
51Polyuria (HP:0000103)2.36393950
52Ventricular fibrillation (HP:0001663)2.35719118
53Split foot (HP:0001839)2.34757355
54Postural tremor (HP:0002174)2.34584356
55Depression (HP:0000716)2.33903765
56Double outlet right ventricle (HP:0001719)2.31273350
57Congenital malformation of the right heart (HP:0011723)2.31273350
58Choreoathetosis (HP:0001266)2.29757416
59Dysmetria (HP:0001310)2.26254914
60Hypomagnesemia (HP:0002917)2.26154230
61Broad-based gait (HP:0002136)2.24255873
62Syncope (HP:0001279)2.23495091
63Renal salt wasting (HP:0000127)2.22936410
64Facial shape deformation (HP:0011334)2.22784348
65Potter facies (HP:0002009)2.22784348
66Abnormality of saccadic eye movements (HP:0000570)2.21556307
67Spastic gait (HP:0002064)2.20297564
68Abnormality of chloride homeostasis (HP:0011422)2.19820333
69Hyperinsulinemic hypoglycemia (HP:0000825)2.19182609
70Overgrowth (HP:0001548)2.17965345
71Plantar hyperkeratosis (HP:0007556)2.17571030
72Humeroradial synostosis (HP:0003041)2.17551940
73Synostosis involving the elbow (HP:0003938)2.17551940
74Akinesia (HP:0002304)2.17070705
75Intention tremor (HP:0002080)2.16681178
76Craniofacial dystonia (HP:0012179)2.16168675
77Abnormality of renin-angiotensin system (HP:0000847)2.14343444
78Hyperthyroidism (HP:0000836)2.14220537
79Bundle branch block (HP:0011710)2.14071232
80Abnormality of the middle phalanges of the toes (HP:0010183)2.12314461
81Sensory axonal neuropathy (HP:0003390)2.11757426
82Amelogenesis imperfecta (HP:0000705)2.10254169
83Poor eye contact (HP:0000817)2.09784939
84Impaired smooth pursuit (HP:0007772)2.08172137
85Tetany (HP:0001281)2.08126617
86Abnormality of dental color (HP:0011073)2.07678316
87Postural instability (HP:0002172)2.07218616
88Impaired social interactions (HP:0000735)2.05577495
89Abnormal social behavior (HP:0012433)2.05577495
90Clumsiness (HP:0002312)2.05514026
91Abnormal hair laboratory examination (HP:0003328)2.05315199
92Hypokinesia (HP:0002375)2.04661578
93Epileptiform EEG discharges (HP:0011182)2.03247616
94Abnormality of renal resorption (HP:0011038)2.02229328
95Abnormality of magnesium homeostasis (HP:0004921)2.02133158
96Abnormality of nail color (HP:0100643)1.99460142
97Abnormal drinking behavior (HP:0030082)1.98278785
98Polydipsia (HP:0001959)1.98278785
99Neuronal loss in central nervous system (HP:0002529)1.97374262
100Pheochromocytoma (HP:0002666)1.96087163
101Chronic bronchitis (HP:0004469)1.95499749
102Hyperphosphatemia (HP:0002905)1.94813184
103Lip pit (HP:0100267)1.94546121
104Hypoglycemic seizures (HP:0002173)1.91900298
105Diminished movement (HP:0002374)1.91070203
106Bronchomalacia (HP:0002780)1.90519273
107Limb dystonia (HP:0002451)1.90466938
108EEG with generalized epileptiform discharges (HP:0011198)1.89960941
109Impaired vibration sensation in the lower limbs (HP:0002166)1.89293229
110Abnormality of the corticospinal tract (HP:0002492)1.88634171
111Impaired vibratory sensation (HP:0002495)1.88049268
112Morphological abnormality of the inner ear (HP:0011390)1.85475134
113Genetic anticipation (HP:0003743)1.84615915
114Rigidity (HP:0002063)1.83995972
115Horizontal nystagmus (HP:0000666)1.83692833
116Ketoacidosis (HP:0001993)1.82924903
117Fragile nails (HP:0001808)1.81124268
118Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81096645
119Obstructive sleep apnea (HP:0002870)1.80629434
120Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80484239
121Thyroid-stimulating hormone excess (HP:0002925)1.79678098
122Ankle clonus (HP:0011448)1.79361905
123Abnormality of ocular smooth pursuit (HP:0000617)1.78956776
124Limb ataxia (HP:0002070)1.78773566
125Stereotypic behavior (HP:0000733)1.78651495
126Amblyopia (HP:0000646)1.78528664
127Decreased circulating renin level (HP:0003351)1.76492133
128Adrenal overactivity (HP:0002717)1.75869824
129Hypsarrhythmia (HP:0002521)1.75494887
130Bradykinesia (HP:0002067)1.74771692
131Incomplete penetrance (HP:0003829)1.74426788
132Decreased activity of mitochondrial respiratory chain (HP:0008972)1.73912374
133Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.73912374
134Palmoplantar hyperkeratosis (HP:0000972)1.73110114
135Villous atrophy (HP:0011473)1.72398494
136Abnormality of small intestinal villus morphology (HP:0011472)1.72398494
137Osteomalacia (HP:0002749)1.71960983
138Clonus (HP:0002169)1.71026946
139Degeneration of the lateral corticospinal tracts (HP:0002314)1.70441684
140Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.70441684
141Abnormality of the salivary glands (HP:0010286)1.70397072
142Abnormality of calcium-phosphate metabolism (HP:0100530)1.68217655
143Athetosis (HP:0002305)1.68069824
144Gait ataxia (HP:0002066)1.68033690
145Mixed hearing impairment (HP:0000410)1.67337745
146Confusion (HP:0001289)1.65838472
147Neuroendocrine neoplasm (HP:0100634)1.65642539
148Hypokalemia (HP:0002900)1.64943715
149Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.63653825
150Dysmetric saccades (HP:0000641)1.63532171
151Urinary urgency (HP:0000012)1.63392684

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.09120290
2NTRK33.78435222
3LMTK23.18871216
4MST1R2.89252690
5MAP3K92.73381570
6MAP3K42.35697960
7DAPK22.28836808
8MINK12.18429598
9OXSR12.16105599
10MAP2K71.88461609
11WNK31.86320916
12CASK1.81138211
13AKT31.78421255
14NTRK21.73058014
15MAP3K21.71089164
16TNIK1.70464619
17RIPK41.64981119
18KSR21.64516194
19STK381.60719234
20PHKG21.60188178
21PHKG11.60188178
22WNK41.59102085
23MET1.58078699
24NTRK11.48366697
25PRKD31.48295563
26CAMKK11.47347974
27MAP2K41.41591764
28MAP3K121.40284048
29PAK61.35076155
30SGK4941.33276618
31SGK2231.33276618
32CAMKK21.32179548
33STK391.31291601
34SGK21.27400806
35DAPK11.27322556
36CDK191.25195385
37CDK51.20577217
38FER1.17999245
39FRK1.15459495
40NME11.14989128
41PRKCG1.13399628
42BRSK11.08896922
43KSR11.08774094
44RIPK11.07350854
45PBK1.04901833
46STK31.04522934
47SGK31.04457385
48MARK11.04287507
49PRPF4B1.03798000
50MST41.01405274
51PLK21.00294629
52STK240.95036270
53PINK10.94299178
54SCYL20.93144212
55TESK10.91722639
56WNK10.91605141
57STK38L0.89194257
58CAMK2A0.89181228
59FGFR20.89044001
60CAMK2B0.86463678
61BRAF0.86130616
62GRK50.85198233
63TRIB30.83901843
64MUSK0.83001091
65EPHA20.81481538
66DAPK30.80683097
67TNK20.80520335
68MAP3K130.76815266
69ARAF0.75076361
70SGK10.74575012
71BMPR20.74364461
72CAMK10.73689370
73PAK30.72065183
74CAMK2G0.71272707
75PNCK0.70988766
76SIK10.69269419
77MAPK130.68650910
78PTK20.68263520
79DYRK1A0.68199623
80TSSK60.68112688
81PRKCE0.67601272
82ROCK20.66001030
83TLK10.65780063
84RET0.65317636
85PDK30.65129713
86PDK40.65129713
87MAP2K10.65076614
88NEK60.63425996
89IRAK20.62428344
90INSRR0.60850709
91TYRO30.58975891
92EIF2AK10.58749530
93PDPK10.58156928
94ADRBK10.57820532
95AKT20.57623908
96CAMK2D0.57404918
97PDK20.57084505
98ALK0.56980298
99DDR20.56949075
100CDK180.56898862
101PRKG20.56176238
102CDK150.55314034
103NME20.53797986
104LATS20.52222330
105CDK140.51700551
106PTK2B0.51640458
107STK160.51083246
108MAPK120.50153247
109TTK0.49705285
110CDC42BPA0.48888898
111MAP3K70.46793549
112TRIM280.46566715
113LIMK10.46362549
114CDK11A0.44440081
115PRKCH0.43418925
116CAMK1G0.43358357
117ZAK0.42889819
118PDK10.42560802
119CSNK1A10.42306450
120MAP3K10.41824117
121NEK10.41387825
122PRKCA0.40866784
123PAK40.40567941
124PRKCI0.40374860
125MARK20.40305953
126ROCK10.39488980
127UHMK10.39486787
128MAP2K60.39484628
129CSNK1E0.39437481
130STK110.39258395
131RPS6KA30.37910467
132EIF2AK30.37365384
133CSNK1G20.34562173
134BMX0.34310762

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.35544151
2Synaptic vesicle cycle_Homo sapiens_hsa047212.78997424
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.75132888
4Nitrogen metabolism_Homo sapiens_hsa009102.51558190
5GABAergic synapse_Homo sapiens_hsa047272.31648043
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.28794236
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22582600
8Long-term potentiation_Homo sapiens_hsa047202.21327723
9Glutamatergic synapse_Homo sapiens_hsa047242.20667949
10Salivary secretion_Homo sapiens_hsa049702.18004473
11Gastric acid secretion_Homo sapiens_hsa049712.16479484
12Circadian entrainment_Homo sapiens_hsa047132.14440341
13Insulin secretion_Homo sapiens_hsa049112.03466035
14Amphetamine addiction_Homo sapiens_hsa050311.97825668
15Morphine addiction_Homo sapiens_hsa050321.95407763
16Vitamin B6 metabolism_Homo sapiens_hsa007501.94371841
17Fatty acid biosynthesis_Homo sapiens_hsa000611.93586250
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.88549547
19Olfactory transduction_Homo sapiens_hsa047401.85409690
20Taste transduction_Homo sapiens_hsa047421.77930278
21Collecting duct acid secretion_Homo sapiens_hsa049661.73182770
22Thyroid hormone synthesis_Homo sapiens_hsa049181.68541372
23Pancreatic secretion_Homo sapiens_hsa049721.62405107
24Dopaminergic synapse_Homo sapiens_hsa047281.56812069
25Cocaine addiction_Homo sapiens_hsa050301.38048426
26Vibrio cholerae infection_Homo sapiens_hsa051101.35458368
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34997872
28Renin secretion_Homo sapiens_hsa049241.34874192
29Long-term depression_Homo sapiens_hsa047301.33671217
30Cholinergic synapse_Homo sapiens_hsa047251.31358203
31Calcium signaling pathway_Homo sapiens_hsa040201.27741883
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25646878
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25077957
34Mineral absorption_Homo sapiens_hsa049781.19394067
35Folate biosynthesis_Homo sapiens_hsa007901.19131015
36Serotonergic synapse_Homo sapiens_hsa047261.16790506
37Sulfur relay system_Homo sapiens_hsa041221.16270618
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14331701
39cAMP signaling pathway_Homo sapiens_hsa040241.09688804
40Oxytocin signaling pathway_Homo sapiens_hsa049211.07284597
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07038836
42Bile secretion_Homo sapiens_hsa049761.06976032
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.01232535
44GnRH signaling pathway_Homo sapiens_hsa049121.01035892
45Circadian rhythm_Homo sapiens_hsa047100.98516851
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98126063
47Sulfur metabolism_Homo sapiens_hsa009200.96565891
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95428363
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94986872
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94301008
51Gap junction_Homo sapiens_hsa045400.94295351
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94277443
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90681652
54Melanogenesis_Homo sapiens_hsa049160.90188061
55Estrogen signaling pathway_Homo sapiens_hsa049150.86893079
56Cardiac muscle contraction_Homo sapiens_hsa042600.85938928
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85684526
58Arginine and proline metabolism_Homo sapiens_hsa003300.85649242
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85586472
60Ovarian steroidogenesis_Homo sapiens_hsa049130.84250871
61Parkinsons disease_Homo sapiens_hsa050120.81865911
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79527893
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78808937
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75997983
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74411437
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72931200
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72504783
68Phenylalanine metabolism_Homo sapiens_hsa003600.71378037
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.70790524
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65692217
71Fructose and mannose metabolism_Homo sapiens_hsa000510.65559185
72Type II diabetes mellitus_Homo sapiens_hsa049300.64914915
73Protein digestion and absorption_Homo sapiens_hsa049740.64608433
74Glioma_Homo sapiens_hsa052140.63612384
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63152873
76Dorso-ventral axis formation_Homo sapiens_hsa043200.62441323
77ErbB signaling pathway_Homo sapiens_hsa040120.60654955
78Glucagon signaling pathway_Homo sapiens_hsa049220.59010199
79Sphingolipid metabolism_Homo sapiens_hsa006000.58539916
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.58168253
81Inositol phosphate metabolism_Homo sapiens_hsa005620.54356191
82Choline metabolism in cancer_Homo sapiens_hsa052310.54047779
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52649760
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52528104
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52503271
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51676500
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51607730
88Histidine metabolism_Homo sapiens_hsa003400.51007674
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49911426
90Alcoholism_Homo sapiens_hsa050340.49377848
91Huntingtons disease_Homo sapiens_hsa050160.49292305
92Alzheimers disease_Homo sapiens_hsa050100.48871215
93Oxidative phosphorylation_Homo sapiens_hsa001900.48041717
94Tight junction_Homo sapiens_hsa045300.47466027
95Fatty acid metabolism_Homo sapiens_hsa012120.47386067
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46730800
97Glycerolipid metabolism_Homo sapiens_hsa005610.45264519
98Axon guidance_Homo sapiens_hsa043600.45127170
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43508882
100Pyruvate metabolism_Homo sapiens_hsa006200.42666899
101Rap1 signaling pathway_Homo sapiens_hsa040150.41579896
102beta-Alanine metabolism_Homo sapiens_hsa004100.41575720
103Dilated cardiomyopathy_Homo sapiens_hsa054140.37955233
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.37097194
105Lysosome_Homo sapiens_hsa041420.35571621
106Propanoate metabolism_Homo sapiens_hsa006400.35531195
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35472118
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.35070307
109Wnt signaling pathway_Homo sapiens_hsa043100.33415450
110Prion diseases_Homo sapiens_hsa050200.32230013
111Protein export_Homo sapiens_hsa030600.31703557
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31054215
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30944721
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.30839901
115Endometrial cancer_Homo sapiens_hsa052130.30523320
116Ether lipid metabolism_Homo sapiens_hsa005650.30101805
117Ras signaling pathway_Homo sapiens_hsa040140.28769699
118Carbon metabolism_Homo sapiens_hsa012000.28729602
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28443859
120MAPK signaling pathway_Homo sapiens_hsa040100.28301545
121N-Glycan biosynthesis_Homo sapiens_hsa005100.27363060
122Biosynthesis of amino acids_Homo sapiens_hsa012300.27176732
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.25794639
124Hippo signaling pathway_Homo sapiens_hsa043900.25472098
125Oocyte meiosis_Homo sapiens_hsa041140.25168292
126Arginine biosynthesis_Homo sapiens_hsa002200.24968676
127Butanoate metabolism_Homo sapiens_hsa006500.24461266
128Linoleic acid metabolism_Homo sapiens_hsa005910.23981864

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