KCNJ12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle contraction (GO:0003009)8.22077283
2creatine metabolic process (GO:0006600)6.38379182
3actin filament-based movement (GO:0030048)6.19115154
4response to muscle activity (GO:0014850)6.04696661
5response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.91151782
6skeletal muscle fiber development (GO:0048741)5.85675534
7response to inactivity (GO:0014854)5.30605170
8neuronal action potential propagation (GO:0019227)5.27120537
9myotube cell development (GO:0014904)5.16619638
10* muscle contraction (GO:0006936)4.94279385
11sarcoplasmic reticulum calcium ion transport (GO:0070296)4.88799435
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.84883027
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.81888195
14glycogen catabolic process (GO:0005980)4.71306407
15skeletal muscle adaptation (GO:0043501)4.66416739
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.64849440
17regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.64027081
18regulation of cell communication by electrical coupling (GO:0010649)4.60387393
19locomotory exploration behavior (GO:0035641)4.57369039
20cardiac muscle hypertrophy (GO:0003300)4.48953865
21actomyosin structure organization (GO:0031032)4.47147113
22* muscle system process (GO:0003012)4.44932137
23regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.38414611
24glucan catabolic process (GO:0009251)4.38244759
25regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.35886237
26NADH metabolic process (GO:0006734)4.32116678
27muscle fiber development (GO:0048747)4.28020022
28striated muscle hypertrophy (GO:0014897)4.26389270
29glycogen biosynthetic process (GO:0005978)4.20873229
30glucan biosynthetic process (GO:0009250)4.20873229
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.19812134
32striated muscle adaptation (GO:0014888)4.08765097
33cellular polysaccharide catabolic process (GO:0044247)4.06666792
34skeletal muscle tissue development (GO:0007519)4.03022049
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.02870282
36plasma membrane repair (GO:0001778)3.99574647
37cell communication by electrical coupling (GO:0010644)3.99082055
38muscle cell cellular homeostasis (GO:0046716)3.97378708
39positive regulation of synapse maturation (GO:0090129)3.97293258
40positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.92675503
41negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.87938015
42regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.81787746
43sarcomere organization (GO:0045214)3.77102872
44negative regulation of potassium ion transmembrane transport (GO:1901380)3.76352524
45regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.75736824
46regulation of short-term neuronal synaptic plasticity (GO:0048172)3.73042367
47muscle hypertrophy (GO:0014896)3.71416384
48cell communication involved in cardiac conduction (GO:0086065)3.68543807
49gluconeogenesis (GO:0006094)3.66565288
50vocalization behavior (GO:0071625)3.65767188
51polysaccharide catabolic process (GO:0000272)3.62644451
52membrane depolarization during action potential (GO:0086010)3.59550558
53skeletal muscle tissue regeneration (GO:0043403)3.59212150
54cerebellar granule cell differentiation (GO:0021707)3.59021876
55synaptic vesicle exocytosis (GO:0016079)3.56024259
56cardiac muscle hypertrophy in response to stress (GO:0014898)3.55551190
57muscle hypertrophy in response to stress (GO:0003299)3.55551190
58cardiac muscle adaptation (GO:0014887)3.55551190
59muscle filament sliding (GO:0030049)3.53855680
60actin-myosin filament sliding (GO:0033275)3.53855680
61synaptic vesicle maturation (GO:0016188)3.52738107
62cardiac muscle contraction (GO:0060048)3.52671518
63regulation of calcium ion transmembrane transporter activity (GO:1901019)3.51443573
64regulation of calcium ion transmembrane transport (GO:1903169)3.51443573
65regulation of membrane repolarization (GO:0060306)3.51190852
66regulation of synaptic vesicle exocytosis (GO:2000300)3.50376100
67positive regulation of myotube differentiation (GO:0010831)3.48423195
68muscle cell fate commitment (GO:0042693)3.47910973
69relaxation of muscle (GO:0090075)3.47107595
70positive regulation of potassium ion transmembrane transport (GO:1901381)3.43139030
71sodium ion export (GO:0071436)3.43025913
722-oxoglutarate metabolic process (GO:0006103)3.41372846
73muscle tissue morphogenesis (GO:0060415)3.40185639
74detection of calcium ion (GO:0005513)3.40011931
75neuron cell-cell adhesion (GO:0007158)3.39975214
76cellular potassium ion homeostasis (GO:0030007)3.39265983
77glycogen metabolic process (GO:0005977)3.38116767
78cerebellar Purkinje cell differentiation (GO:0021702)3.37272920
79muscle organ development (GO:0007517)3.36222798
80regulation of synapse maturation (GO:0090128)3.35491929
81muscle structure development (GO:0061061)3.33773070
82neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.32048546
83synaptic vesicle docking involved in exocytosis (GO:0016081)3.31476640
84positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.30492764
85striated muscle cell development (GO:0055002)3.30449684
86glucan metabolic process (GO:0044042)3.29867072
87cellular glucan metabolic process (GO:0006073)3.29867072
88adult heart development (GO:0007512)3.29442834
89potassium ion import (GO:0010107)3.28794695
90cardiac muscle tissue morphogenesis (GO:0055008)3.26792789
91regulation of skeletal muscle contraction (GO:0014819)3.25980387
92hexose biosynthetic process (GO:0019319)3.24744545
93muscle adaptation (GO:0043500)3.24248347
94transmission of nerve impulse (GO:0019226)3.23635219
95positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.23463384
96tricarboxylic acid cycle (GO:0006099)3.23239385
97myofibril assembly (GO:0030239)3.21368975
98muscle organ morphogenesis (GO:0048644)3.20189329
99G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.19801175
100regulation of actin filament-based movement (GO:1903115)3.19604653
101gamma-aminobutyric acid signaling pathway (GO:0007214)3.19444275
102regulation of the force of heart contraction (GO:0002026)3.19432598
103regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.18824999
104striated muscle contraction (GO:0006941)3.18589955
105fructose metabolic process (GO:0006000)3.15140240
106regulation of relaxation of muscle (GO:1901077)3.14520289
107exploration behavior (GO:0035640)3.13544722
108myotube differentiation (GO:0014902)3.13199709
109striated muscle atrophy (GO:0014891)3.12861830
110gamma-aminobutyric acid transport (GO:0015812)3.12378725
111glutamate secretion (GO:0014047)3.12299908
112glutamate receptor signaling pathway (GO:0007215)3.07636918
113regulation of sodium ion transmembrane transport (GO:1902305)3.06707993
114regulation of skeletal muscle cell differentiation (GO:2001014)3.06617227
115protein localization to synapse (GO:0035418)3.06519542
116neurotransmitter secretion (GO:0007269)3.06068703
117cardiac myofibril assembly (GO:0055003)3.05862974
118ionotropic glutamate receptor signaling pathway (GO:0035235)3.05484103
119regulation of synaptic vesicle transport (GO:1902803)3.05316152
120negative regulation of cytosolic calcium ion concentration (GO:0051481)3.05076989
121mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.04167276
122regulation of voltage-gated calcium channel activity (GO:1901385)3.03078128
123negative regulation of calcium ion transmembrane transport (GO:1903170)3.02094925
124negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.02094925
125response to activity (GO:0014823)2.99291440
126positive regulation of potassium ion transport (GO:0043268)2.98337926
127regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.97927074
128regulation of striated muscle contraction (GO:0006942)2.96873580
129neuromuscular process controlling posture (GO:0050884)2.95452510
130actin-mediated cell contraction (GO:0070252)2.95245625
131mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94061586
132response to pheromone (GO:0019236)2.94051899
133negative regulation of cation channel activity (GO:2001258)2.93926994
134neuronal ion channel clustering (GO:0045161)2.92649248
135regulation of cation channel activity (GO:2001257)2.92602735
136positive regulation of sodium ion transport (GO:0010765)2.92566176
137detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.90281213
138detection of temperature stimulus involved in sensory perception (GO:0050961)2.90281213
139regulation of synapse structural plasticity (GO:0051823)2.85580148
140synaptic transmission, glutamatergic (GO:0035249)2.83213405
141neuron-neuron synaptic transmission (GO:0007270)2.83164999
142cell differentiation in hindbrain (GO:0021533)2.82909190
143negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.82833625
144C4-dicarboxylate transport (GO:0015740)2.82736277
145activation of protein kinase A activity (GO:0034199)2.82200914
146multicellular organismal signaling (GO:0035637)2.81277776
147positive regulation of sodium ion transmembrane transport (GO:1902307)2.79803399
148potassium ion homeostasis (GO:0055075)2.79615121
149cell migration in hindbrain (GO:0021535)2.78787225
150membrane repolarization (GO:0086009)2.77302483
151regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.74671735
152ventricular cardiac muscle cell action potential (GO:0086005)2.73811210
153regulation of cardiac muscle contraction (GO:0055117)2.73278832
154regulation of potassium ion transmembrane transport (GO:1901379)2.72445816
155positive regulation of ion transmembrane transporter activity (GO:0032414)2.72345354
156positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.71255530
157mating behavior (GO:0007617)2.70862056
158positive regulation of cation channel activity (GO:2001259)2.70530165
159neuromuscular synaptic transmission (GO:0007274)2.69539691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.13497196
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.75256848
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10811100
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.09922709
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94247777
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.81009320
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65811535
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65811535
9GBX2_23144817_ChIP-Seq_PC3_Human2.59933742
10DROSHA_22980978_ChIP-Seq_HELA_Human2.55648454
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51431782
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49290287
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39486872
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38853038
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.36966920
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.35309308
17REST_21632747_ChIP-Seq_MESCs_Mouse2.29829091
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23848166
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16403556
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.13491153
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09510869
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.07095001
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.03134597
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.02763779
25ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.98581704
26PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.96528080
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93942730
28AR_21572438_ChIP-Seq_LNCaP_Human1.82653836
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81979535
30SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.73960555
31TAF15_26573619_Chip-Seq_HEK293_Human1.73306978
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73223773
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.72971497
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66239153
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65521893
36ZNF274_21170338_ChIP-Seq_K562_Hela1.61706667
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59968526
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59932283
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.59757996
40MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.56417140
41BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.50934827
42LXR_22292898_ChIP-Seq_THP-1_Human1.49489454
43* SMAD4_21799915_ChIP-Seq_A2780_Human1.48118706
44* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43566692
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42969745
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42372463
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42338377
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.40427497
49* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39626132
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.38322327
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34229978
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.33102209
53CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32677733
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32178642
55STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.30348695
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29159253
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25910604
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25376456
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21631784
60NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20919426
61AR_19668381_ChIP-Seq_PC3_Human1.20225771
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19940053
63KDM2B_26808549_Chip-Seq_DND41_Human1.19790908
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.18630126
65MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.17067853
66SA1_27219007_Chip-Seq_Bcells_Human1.16001130
67ZNF263_19887448_ChIP-Seq_K562_Human1.15691256
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15423752
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15370573
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.15335589
71TRIM28_21343339_ChIP-Seq_HEK293_Human1.15199509
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.14537733
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13226034
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13136093
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12065870
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11956637
77* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11019204
78NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10894837
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.10845985
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10467241
81* SMC4_20622854_ChIP-Seq_HELA_Human1.09827905
82AHR_22903824_ChIP-Seq_MCF-7_Human1.09716566
83CTCF_27219007_Chip-Seq_Bcells_Human1.09508534
84STAT3_23295773_ChIP-Seq_U87_Human1.08796722
85SMC3_22415368_ChIP-Seq_MEFs_Mouse1.08732208
86* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08054005
87SMAD4_21741376_ChIP-Seq_HESCs_Human1.06818342
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06701149
89MYC_27129775_Chip-Seq_CORNEA_Mouse1.06655925
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06284643
91NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06172544
92P300_19829295_ChIP-Seq_ESCs_Human1.04831031
93OCT4_19829295_ChIP-Seq_ESCs_Human1.04291352
94KDM2B_26808549_Chip-Seq_K562_Human1.03287154
95P68_20966046_ChIP-Seq_HELA_Human1.02225058
96* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02134729
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01050758
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01031713
99CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00445269
100TP53_23651856_ChIP-Seq_MEFs_Mouse1.00347250
101CREB1_26743006_Chip-Seq_LNCaP_Human0.99512829
102* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98655680
103ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98599584
104AR_25329375_ChIP-Seq_VCAP_Human0.98536629
105RING1B_27294783_Chip-Seq_NPCs_Mouse0.97538993
106DPY_21335234_ChIP-Seq_ESCs_Mouse0.97523554
107ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97042741
108TCF4_23295773_ChIP-Seq_U87_Human0.96943344
109ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96650696
110GATA4_21415370_ChIP-Seq_HL-1_Mouse0.96467614
111ARNT_22903824_ChIP-Seq_MCF-7_Human0.96307519
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95673608
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95652093
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95085842
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.94949307
116BCAT_22108803_ChIP-Seq_LS180_Human0.93871536
117TET1_21451524_ChIP-Seq_MESCs_Mouse0.93674791
118* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93668636
119* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93459575
120* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92498839
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92471593
122TBX20_22080862_ChIP-Seq_HEART_Mouse0.92252886
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.92252886
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92103021
125ESR2_21235772_ChIP-Seq_MCF-7_Human0.91838711
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91763234
127ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90826439
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90734083
129IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90500682
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.90471748
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.90284667
132TET1_21490601_ChIP-Seq_MESCs_Mouse0.90221644
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89364430
134* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89043627
135GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87914389
136ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87905090
137SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86985625
138OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86927147
139* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.86328195
140RACK7_27058665_Chip-Seq_MCF-7_Human0.86266506
141ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86224538
142SMAD4_21741376_ChIP-Seq_EPCs_Human0.85934092
143TP53_20018659_ChIP-ChIP_R1E_Mouse0.85854243
144SPI1_20517297_ChIP-Seq_HL60_Human0.84966282
145* SA1_27219007_Chip-Seq_ERYTHROID_Human0.82909810
146E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.82799624

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.08414197
2MP0004145_abnormal_muscle_electrophysio3.99062772
3MP0000751_myopathy3.84006701
4MP0003646_muscle_fatigue3.59908679
5MP0004859_abnormal_synaptic_plasticity3.35983367
6MP0004270_analgesia2.96160447
7MP0004036_abnormal_muscle_relaxation2.95682246
8MP0000749_muscle_degeneration2.88047315
9MP0005451_abnormal_body_composition2.84926508
10MP0009046_muscle_twitch2.80705178
11MP0004084_abnormal_cardiac_muscle2.70700088
12MP0004215_abnormal_myocardial_fiber2.68447375
13MP0003635_abnormal_synaptic_transmissio2.62693782
14MP0003880_abnormal_central_pattern2.45526121
15MP0002272_abnormal_nervous_system2.29933291
16MP0002064_seizures2.23715765
17MP0009745_abnormal_behavioral_response2.22718971
18MP0001968_abnormal_touch/_nociception2.18307403
19MP0002735_abnormal_chemical_nociception2.16662959
20MP0002734_abnormal_mechanical_nocicepti2.15434380
21MP0000747_muscle_weakness2.07196295
22MP0000733_abnormal_muscle_development2.05843107
23MP0003137_abnormal_impulse_conducting1.95638484
24MP0008569_lethality_at_weaning1.87772274
25MP0002106_abnormal_muscle_physiology1.85835132
26MP0002063_abnormal_learning/memory/cond1.84054527
27MP0004087_abnormal_muscle_fiber1.82860466
28MP0002067_abnormal_sensory_capabilities1.82664873
29MP0001440_abnormal_grooming_behavior1.80852731
30MP0002822_catalepsy1.79162222
31MP0005330_cardiomyopathy1.78091343
32MP0005620_abnormal_muscle_contractility1.76941737
33MP0002572_abnormal_emotion/affect_behav1.73638137
34MP0002269_muscular_atrophy1.67998230
35MP0002733_abnormal_thermal_nociception1.67593256
36MP0004233_abnormal_muscle_weight1.64259215
37MP0001970_abnormal_pain_threshold1.63678572
38MP0001486_abnormal_startle_reflex1.60303422
39MP0003329_amyloid_beta_deposits1.60031728
40MP0000759_abnormal_skeletal_muscle1.59505975
41MP0005369_muscle_phenotype1.58519923
42MP0002184_abnormal_innervation1.58118383
43MP0002972_abnormal_cardiac_muscle1.56104831
44MP0004130_abnormal_muscle_cell1.55282729
45MP0002736_abnormal_nociception_after1.54993069
46MP0002909_abnormal_adrenal_gland1.54563302
47MP0004858_abnormal_nervous_system1.52406979
48MP0004085_abnormal_heartbeat1.51204453
49MP0006276_abnormal_autonomic_nervous1.46192254
50MP0001501_abnormal_sleep_pattern1.44922499
51MP0005423_abnormal_somatic_nervous1.44690588
52MP0004484_altered_response_of1.43263408
53MP0004142_abnormal_muscle_tone1.43065893
54MP0005386_behavior/neurological_phenoty1.41140640
55MP0004924_abnormal_behavior1.41140640
56MP0008775_abnormal_heart_ventricle1.28961836
57MP0003183_abnormal_peptide_metabolism1.25266911
58MP0000750_abnormal_muscle_regeneration1.20680902
59MP0000955_abnormal_spinal_cord1.19307007
60MP0000778_abnormal_nervous_system1.19117404
61MP0002066_abnormal_motor_capabilities/c1.18313414
62MP0002332_abnormal_exercise_endurance1.17920674
63MP0005266_abnormal_metabolism1.15834948
64MP0001984_abnormal_olfaction1.12038599
65MP0004147_increased_porphyrin_level1.11287030
66MP0002882_abnormal_neuron_morphology1.09839367
67MP0000920_abnormal_myelination1.08720353
68MP0009780_abnormal_chondrocyte_physiolo1.06214567
69MP0002557_abnormal_social/conspecific_i1.05504245
70MP0006138_congestive_heart_failure1.05384776
71MP0002229_neurodegeneration1.03257541
72MP0005623_abnormal_meninges_morphology1.02943072
73MP0005551_abnormal_eye_electrophysiolog1.02804217
74MP0001529_abnormal_vocalization1.00711312
75MP0006072_abnormal_retinal_apoptosis1.00178809
76MP0001544_abnormal_cardiovascular_syste1.00017573
77MP0005385_cardiovascular_system_phenoty1.00017573
78MP0002971_abnormal_brown_adipose0.98100899
79MP0004811_abnormal_neuron_physiology0.92081800
80MP0004185_abnormal_adipocyte_glucose0.91779133
81MP0004043_abnormal_pH_regulation0.91235424
82MP0004510_myositis0.90304311
83MP0001299_abnormal_eye_distance/0.89897112
84MP0004742_abnormal_vestibular_system0.89253440
85MP0000013_abnormal_adipose_tissue0.89222125
86MP0010630_abnormal_cardiac_muscle0.88917775
87MP0002108_abnormal_muscle_morphology0.88659663
88MP0004885_abnormal_endolymph0.88390073
89MP0005670_abnormal_white_adipose0.87162581
90MP0002163_abnormal_gland_morphology0.86821171
91MP0006036_abnormal_mitochondrial_physio0.86708003
92MP0001502_abnormal_circadian_rhythm0.84487252
93MP0006035_abnormal_mitochondrial_morpho0.83351737
94MP0003879_abnormal_hair_cell0.83001575
95MP0003633_abnormal_nervous_system0.82426574
96MP0005379_endocrine/exocrine_gland_phen0.81945118
97MP0003690_abnormal_glial_cell0.81901628
98MP0003634_abnormal_glial_cell0.81460365
99MP0000003_abnormal_adipose_tissue0.80478278
100MP0002752_abnormal_somatic_nervous0.79649150
101MP0005375_adipose_tissue_phenotype0.78631027
102MP0005666_abnormal_adipose_tissue0.77721373
103MP0003632_abnormal_nervous_system0.77536610
104MP0001485_abnormal_pinna_reflex0.77274326
105MP0001346_abnormal_lacrimal_gland0.76764825
106MP0003631_nervous_system_phenotype0.75983787
107MP0008874_decreased_physiological_sensi0.72881003
108MP0003950_abnormal_plasma_membrane0.72658238
109MP0010030_abnormal_orbit_morphology0.72275797
110MP0003221_abnormal_cardiomyocyte_apopto0.71297699
111MP0002090_abnormal_vision0.70721013
112MP0002127_abnormal_cardiovascular_syste0.69897086
113MP0001661_extended_life_span0.69624383
114MP0002152_abnormal_brain_morphology0.67210080
115MP0002638_abnormal_pupillary_reflex0.63406858
116MP0003045_fibrosis0.55424944
117MP0005167_abnormal_blood-brain_barrier0.52996258
118MP0005535_abnormal_body_temperature0.51420521
119MP0000266_abnormal_heart_morphology0.50731259
120MP0002249_abnormal_larynx_morphology0.49436721
121MP0009672_abnormal_birth_weight0.43205879
122MP0003656_abnormal_erythrocyte_physiolo0.42290110
123MP0000579_abnormal_nail_morphology0.41984627
124MP0002114_abnormal_axial_skeleton0.41730446
125MP0002078_abnormal_glucose_homeostasis0.40748433
126MP0003828_pulmonary_edema0.39434243
127MP0005452_abnormal_adipose_tissue0.39417922
128MP0002234_abnormal_pharynx_morphology0.38693147
129MP0003123_paternal_imprinting0.38556002
130MP0001943_abnormal_respiration0.38504235

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.43211160
2Muscle hypertrophy of the lower extremities (HP:0008968)5.25484097
3Calf muscle hypertrophy (HP:0008981)5.03240492
4Sudden death (HP:0001699)4.62284103
5Exercise-induced muscle cramps (HP:0003710)4.59377376
6Centrally nucleated skeletal muscle fibers (HP:0003687)4.45651805
7Myotonia (HP:0002486)4.21622036
8Ulnar deviation of the wrist (HP:0003049)4.21572044
9Focal motor seizures (HP:0011153)4.11334326
10Calcaneovalgus deformity (HP:0001848)3.95945964
11Myokymia (HP:0002411)3.91121250
12Abnormality of the calf musculature (HP:0001430)3.90680785
13Atonic seizures (HP:0010819)3.73350825
14Hyporeflexia of lower limbs (HP:0002600)3.67400976
15Visual hallucinations (HP:0002367)3.57643984
16Muscle fiber splitting (HP:0003555)3.57529626
17Myoglobinuria (HP:0002913)3.54856921
18Deformed tarsal bones (HP:0008119)3.49551277
19EMG: myopathic abnormalities (HP:0003458)3.47295396
20Focal seizures (HP:0007359)3.41696715
21Distal lower limb muscle weakness (HP:0009053)3.39912508
22Frequent falls (HP:0002359)3.39579572
23Absent phalangeal crease (HP:0006109)3.38721290
24Action tremor (HP:0002345)3.35891870
25Febrile seizures (HP:0002373)3.35160264
26Difficulty running (HP:0009046)3.30915876
27Bundle branch block (HP:0011710)3.26037585
28Ventricular fibrillation (HP:0001663)3.21897431
29Progressive cerebellar ataxia (HP:0002073)3.20925181
30Pheochromocytoma (HP:0002666)3.16836157
31Muscle fiber inclusion bodies (HP:0100299)3.16108666
32Malignant hyperthermia (HP:0002047)3.08455964
33Prolonged QT interval (HP:0001657)3.07367092
34Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.05140337
35Atrial fibrillation (HP:0005110)2.96979234
36Neuroendocrine neoplasm (HP:0100634)2.90647113
37Distal arthrogryposis (HP:0005684)2.90506133
38Primary atrial arrhythmia (HP:0001692)2.87962353
39Syncope (HP:0001279)2.87528186
40Muscle stiffness (HP:0003552)2.86246283
41Ventricular tachycardia (HP:0004756)2.83892869
42Subaortic stenosis (HP:0001682)2.83621676
43Abnormality of the left ventricular outflow tract (HP:0011103)2.83621676
44Absence seizures (HP:0002121)2.80137409
45Abnormal finger flexion creases (HP:0006143)2.76509994
46Mildly elevated creatine phosphokinase (HP:0008180)2.75150632
47Supraventricular tachycardia (HP:0004755)2.74955686
48Generalized muscle weakness (HP:0003324)2.72025296
49Supraventricular arrhythmia (HP:0005115)2.68399634
50Nemaline bodies (HP:0003798)2.62609954
51Acute necrotizing encephalopathy (HP:0006965)2.58386672
52Dialeptic seizures (HP:0011146)2.56424157
53Dysmetric saccades (HP:0000641)2.55754505
54Distal lower limb amyotrophy (HP:0008944)2.54987063
55Increased variability in muscle fiber diameter (HP:0003557)2.54852509
56Gaze-evoked nystagmus (HP:0000640)2.54398351
57Dysdiadochokinesis (HP:0002075)2.53334602
58Bulbar palsy (HP:0001283)2.51254656
59Broad-based gait (HP:0002136)2.47705299
60Generalized tonic-clonic seizures (HP:0002069)2.47341853
61Epileptic encephalopathy (HP:0200134)2.46317258
62Abnormal mitochondria in muscle tissue (HP:0008316)2.44836705
63Weak cry (HP:0001612)2.41792662
64Abnormal EKG (HP:0003115)2.39495812
65Abnormality of the parathyroid morphology (HP:0011766)2.37959472
66Palpitations (HP:0001962)2.37213640
67Heart block (HP:0012722)2.36996759
68Type 1 muscle fiber predominance (HP:0003803)2.33993310
69Vertebral arch anomaly (HP:0008438)2.32927922
70Progressive muscle weakness (HP:0003323)2.32796713
71Fetal akinesia sequence (HP:0001989)2.30137191
72Scanning speech (HP:0002168)2.28546574
73Abnormality of skeletal muscle fiber size (HP:0012084)2.27544506
74Myopathic facies (HP:0002058)2.27032267
75Ventricular arrhythmia (HP:0004308)2.25801615
76Abnormality of the neuromuscular junction (HP:0003398)2.24624858
77Fatigable weakness (HP:0003473)2.24624858
78Lower limb amyotrophy (HP:0007210)2.24169261
79Progressive macrocephaly (HP:0004481)2.23622301
80Spinal rigidity (HP:0003306)2.22045085
81Dysmetria (HP:0001310)2.21969956
82Abnormality of the calcaneus (HP:0008364)2.21618037
83Slender build (HP:0001533)2.20632468
84Hyperkalemia (HP:0002153)2.18083659
85Abnormal atrioventricular conduction (HP:0005150)2.16474983
86Rhabdomyolysis (HP:0003201)2.14801001
87Increased connective tissue (HP:0009025)2.14024189
88Asymmetric septal hypertrophy (HP:0001670)2.11296365
89Central scotoma (HP:0000603)2.11214769
90Left ventricular hypertrophy (HP:0001712)2.07979842
91Anxiety (HP:0000739)2.07931355
92Hip contracture (HP:0003273)2.04801430
93Difficulty climbing stairs (HP:0003551)2.04789013
94EMG: neuropathic changes (HP:0003445)2.04763805
95Depression (HP:0000716)2.03193794
96Acute encephalopathy (HP:0006846)2.02179283
97Atrioventricular block (HP:0001678)2.01935201
98Truncal ataxia (HP:0002078)2.01450517
99Mitochondrial inheritance (HP:0001427)2.01030389
100Proximal amyotrophy (HP:0007126)1.98650927
101Lipoatrophy (HP:0100578)1.97400752
102Abnormality of the shoulder girdle musculature (HP:0001435)1.97295749
103Waddling gait (HP:0002515)1.96802720
104Impaired social interactions (HP:0000735)1.95450144
105Abnormal social behavior (HP:0012433)1.95450144
106Ragged-red muscle fibers (HP:0003200)1.95348396
107Postural tremor (HP:0002174)1.92896764
108Poor eye contact (HP:0000817)1.91431038
109Dilated cardiomyopathy (HP:0001644)1.91242999
110J-shaped sella turcica (HP:0002680)1.90851680
111Muscular dystrophy (HP:0003560)1.90033280
112Round ear (HP:0100830)1.89621883
113Respiratory insufficiency due to muscle weakness (HP:0002747)1.88069699
114Popliteal pterygium (HP:0009756)1.85366015
115Areflexia of lower limbs (HP:0002522)1.84153917
116Foot dorsiflexor weakness (HP:0009027)1.83731554
117Neck muscle weakness (HP:0000467)1.82197508
118Neoplasm of the peripheral nervous system (HP:0100007)1.80135641
119Rapidly progressive (HP:0003678)1.78349101
120Gowers sign (HP:0003391)1.77812988
121Abnormality of the corticospinal tract (HP:0002492)1.77586052
122Scapular winging (HP:0003691)1.76278409
123Athetosis (HP:0002305)1.76177023
124Exercise intolerance (HP:0003546)1.75671767
125Rimmed vacuoles (HP:0003805)1.75532344
126Limb-girdle muscle atrophy (HP:0003797)1.75224838
127Nonprogressive disorder (HP:0003680)1.74640655
128Double outlet right ventricle (HP:0001719)1.74474004
129Congenital malformation of the right heart (HP:0011723)1.74474004
130Hepatocellular necrosis (HP:0001404)1.73890245
131Abnormality of the foot musculature (HP:0001436)1.73689476
132Supranuclear gaze palsy (HP:0000605)1.73200828
133Metatarsus adductus (HP:0001840)1.72449868
134Paralysis (HP:0003470)1.58920203
135Type 2 muscle fiber atrophy (HP:0003554)1.58579405
136Ankle clonus (HP:0011448)1.55712702
137Limb-girdle muscle weakness (HP:0003325)1.54640595
138Long clavicles (HP:0000890)1.51007748
139Muscle fiber atrophy (HP:0100295)1.50276164
140Increased intramyocellular lipid droplets (HP:0012240)1.49547407
141Shoulder girdle muscle weakness (HP:0003547)1.47746580
142Abnormality of the musculature of the pelvis (HP:0001469)1.45764217
143Abnormality of the hip-girdle musculature (HP:0001445)1.45764217
144Stridor (HP:0010307)1.45347368
145Ulnar deviation of finger (HP:0009465)1.43510580
146Steppage gait (HP:0003376)1.40788291
147Limited hip movement (HP:0008800)1.40045069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG23.58853862
2PHKG13.58853862
3NTRK32.97961841
4OBSCN2.84092824
5TTN2.62885149
6NTRK12.60643753
7TNIK2.57960912
8MAP3K42.35693041
9PIK3CG2.17983169
10MAP3K92.16485648
11CAMKK22.01961942
12STK391.93103036
13LMTK21.92110153
14MAP2K41.88714005
15PNCK1.80000205
16MINK11.77379546
17GRK51.70169472
18MAPK131.69578564
19PINK11.65960294
20PAK61.63427283
21NME11.62462650
22MAP2K71.58284022
23TYRO31.57933539
24EEF2K1.53559536
25WNK11.52557791
26CAMK2D1.51840361
27MAP2K31.51806725
28MARK11.51130303
29EPHB11.46912346
30UHMK11.43221916
31MUSK1.37747017
32EPHA41.27227028
33KSR21.27113851
34DAPK21.26956971
35NEK11.24430495
36OXSR11.22932955
37PAK31.22624704
38CAMKK11.20770111
39PDK31.18581513
40PDK41.18581513
41RET1.17604386
42STK381.16029028
43FES1.12566308
44WNK41.09485286
45DMPK1.08995320
46PKN21.06945469
47PKN11.05087594
48MYLK1.03837158
49ICK1.03275296
50ROCK21.01734454
51NTRK21.00264244
52CDK50.98380627
53PRPF4B0.93149671
54MAP3K120.92057814
55CAMK2A0.91803818
56MOS0.91796794
57PRKD30.90751577
58IRAK20.88714065
59MAP3K130.88322582
60ROCK10.86378862
61TRPM70.85916126
62PRKCG0.85139706
63MAPK120.84235222
64RIPK10.83480387
65CCNB10.79533128
66LATS20.79118620
67GRK70.77017950
68SGK2230.76025052
69SGK4940.76025052
70INSRR0.75675011
71MAP3K70.74452281
72TRIB30.73105651
73PRKCH0.72593850
74CAMK10.72390818
75AKT20.72356034
76CAMK2G0.72064560
77MAP2K60.69976601
78CASK0.68323959
79CAMK2B0.67274438
80PRKCE0.65211140
81MAPK110.64045742
82* PRKACA0.63893988
83MAP3K20.63868357
84CDK140.62003929
85PIK3CA0.61574298
86CDC42BPA0.61278272
87STK110.60794374
88CAMK1G0.60607178
89PDK20.59907824
90PRKAA10.58495702
91PRKAA20.58049283
92MAPKAPK30.57708836
93PRKD10.57039875
94MAP2K10.56884620
95SGK30.56092460
96CDK190.55987891
97CAMK40.55881447
98PDPK10.54962218
99SGK10.54574690
100DYRK1B0.54047701
101ARAF0.53801106
102PLK20.51554909
103FER0.50735833
104PRKG10.49814500
105CDK150.49119702
106RPS6KA30.48952931
107ALK0.47760423
108MAP3K110.47635277
109CDK180.47262699
110PDK10.46967456
111MARK20.46830942
112TAOK20.45928424
113PRKACB0.44863216
114MAPK100.44728266
115MAPK40.44411432
116MAPK70.44224960
117LIMK10.43945122
118MAP3K10.43669019
119PRKACG0.43185085
120TAOK10.42928472
121RAF10.42879530
122SGK20.38518995
123BRAF0.37714800
124RPS6KB10.33080094
125ERBB30.31497922
126DAPK30.30457423
127TIE10.24800408
128DAPK10.24442395
129BCKDK0.21997192
130RPS6KA10.21523626
131MTOR0.20414677
132MAPKAPK50.19435226
133CDK11A0.18880158
134DYRK1A0.15960494
135PRKG20.13984033
136NEK90.13732115

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042603.11024231
2Nicotine addiction_Homo sapiens_hsa050332.78201621
3Synaptic vesicle cycle_Homo sapiens_hsa047212.44973592
4Oxidative phosphorylation_Homo sapiens_hsa001902.38637019
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.35942377
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23403662
7GABAergic synapse_Homo sapiens_hsa047272.20038490
8Glutamatergic synapse_Homo sapiens_hsa047242.12125976
9Parkinsons disease_Homo sapiens_hsa050122.08171066
10Dilated cardiomyopathy_Homo sapiens_hsa054142.07051855
11Circadian entrainment_Homo sapiens_hsa047132.01167078
12Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.00502608
13Alzheimers disease_Homo sapiens_hsa050101.98433080
14Long-term potentiation_Homo sapiens_hsa047201.95513825
15Taste transduction_Homo sapiens_hsa047421.93025884
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.88136558
17Arginine and proline metabolism_Homo sapiens_hsa003301.87230277
18Morphine addiction_Homo sapiens_hsa050321.82646164
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82025708
20Arginine biosynthesis_Homo sapiens_hsa002201.78980106
21Insulin secretion_Homo sapiens_hsa049111.75147887
22Salivary secretion_Homo sapiens_hsa049701.71303886
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56810359
24Long-term depression_Homo sapiens_hsa047301.56804884
25Olfactory transduction_Homo sapiens_hsa047401.54619999
26Calcium signaling pathway_Homo sapiens_hsa040201.54294600
27Pentose phosphate pathway_Homo sapiens_hsa000301.53564794
28Gastric acid secretion_Homo sapiens_hsa049711.53425401
29* Oxytocin signaling pathway_Homo sapiens_hsa049211.53059676
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52610032
31* Cholinergic synapse_Homo sapiens_hsa047251.50948455
32Dopaminergic synapse_Homo sapiens_hsa047281.50506866
33Serotonergic synapse_Homo sapiens_hsa047261.43027307
34Amphetamine addiction_Homo sapiens_hsa050311.40425432
35Type II diabetes mellitus_Homo sapiens_hsa049301.40395298
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39275479
37Collecting duct acid secretion_Homo sapiens_hsa049661.38049196
38Renin secretion_Homo sapiens_hsa049241.37945111
39Huntingtons disease_Homo sapiens_hsa050161.28823982
40Biosynthesis of amino acids_Homo sapiens_hsa012301.26408964
41Fructose and mannose metabolism_Homo sapiens_hsa000511.21264191
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21207064
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18644783
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17574080
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16498571
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14223258
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13525320
48GnRH signaling pathway_Homo sapiens_hsa049121.12412686
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10619640
50Gap junction_Homo sapiens_hsa045401.07830572
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03349893
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02922212
53Vascular smooth muscle contraction_Homo sapiens_hsa042701.02705902
54cAMP signaling pathway_Homo sapiens_hsa040241.01480467
55Pancreatic secretion_Homo sapiens_hsa049721.00998235
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97697586
57Butanoate metabolism_Homo sapiens_hsa006500.91674483
58Axon guidance_Homo sapiens_hsa043600.88319633
59Nitrogen metabolism_Homo sapiens_hsa009100.86283111
60Estrogen signaling pathway_Homo sapiens_hsa049150.85607949
61Glucagon signaling pathway_Homo sapiens_hsa049220.85200528
62Circadian rhythm_Homo sapiens_hsa047100.82635370
63Phenylalanine metabolism_Homo sapiens_hsa003600.79835030
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79465166
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79458459
66Insulin signaling pathway_Homo sapiens_hsa049100.76472245
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.73960523
68Cocaine addiction_Homo sapiens_hsa050300.73390682
69Vibrio cholerae infection_Homo sapiens_hsa051100.71515959
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69444249
71Dorso-ventral axis formation_Homo sapiens_hsa043200.69408825
72Propanoate metabolism_Homo sapiens_hsa006400.67263992
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66461725
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64463583
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63846721
76Melanogenesis_Homo sapiens_hsa049160.62866358
77Thyroid hormone synthesis_Homo sapiens_hsa049180.60329801
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59795099
79Carbon metabolism_Homo sapiens_hsa012000.59382968
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56934061
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55920372
82Fatty acid elongation_Homo sapiens_hsa000620.54480827
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.54367123
84Glioma_Homo sapiens_hsa052140.54364656
85Fatty acid metabolism_Homo sapiens_hsa012120.53145425
86MAPK signaling pathway_Homo sapiens_hsa040100.52434389
87Choline metabolism in cancer_Homo sapiens_hsa052310.50532871
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50508520
89Starch and sucrose metabolism_Homo sapiens_hsa005000.50094221
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48684596
91Insulin resistance_Homo sapiens_hsa049310.48391686
92Renal cell carcinoma_Homo sapiens_hsa052110.48368432
93Pyruvate metabolism_Homo sapiens_hsa006200.46548089
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.45858924
95AMPK signaling pathway_Homo sapiens_hsa041520.45604446
96Tight junction_Homo sapiens_hsa045300.43272172
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42801597
98ErbB signaling pathway_Homo sapiens_hsa040120.42611406
99Bile secretion_Homo sapiens_hsa049760.42529636
100mTOR signaling pathway_Homo sapiens_hsa041500.41948415
101Oocyte meiosis_Homo sapiens_hsa041140.41918666
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41390009
103beta-Alanine metabolism_Homo sapiens_hsa004100.41375634
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41078660
105Phototransduction_Homo sapiens_hsa047440.40426789
106Inositol phosphate metabolism_Homo sapiens_hsa005620.40325141
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39778872
108Fatty acid biosynthesis_Homo sapiens_hsa000610.38795833
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38489251
110Focal adhesion_Homo sapiens_hsa045100.38434769
111VEGF signaling pathway_Homo sapiens_hsa043700.38384920
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36966410
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36668432
114Sulfur relay system_Homo sapiens_hsa041220.34490305
115Galactose metabolism_Homo sapiens_hsa000520.34037452
116FoxO signaling pathway_Homo sapiens_hsa040680.33761670
117Fatty acid degradation_Homo sapiens_hsa000710.33666027
118Alcoholism_Homo sapiens_hsa050340.31082301
119HIF-1 signaling pathway_Homo sapiens_hsa040660.30610176
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.29714450
121Regulation of autophagy_Homo sapiens_hsa041400.28857024

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »