KCNG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and cancerous tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.73665334
2synaptic vesicle maturation (GO:0016188)6.49841678
3locomotory exploration behavior (GO:0035641)6.37574085
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.34360937
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.91545418
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.81817950
7synaptic vesicle exocytosis (GO:0016079)5.67866999
8regulation of glutamate receptor signaling pathway (GO:1900449)5.64916747
9vocalization behavior (GO:0071625)5.50732129
10regulation of long-term neuronal synaptic plasticity (GO:0048169)5.44420993
11glutamate secretion (GO:0014047)5.40618488
12regulation of neuronal synaptic plasticity (GO:0048168)5.30102327
13synaptic vesicle docking involved in exocytosis (GO:0016081)5.17921907
14ionotropic glutamate receptor signaling pathway (GO:0035235)5.09226619
15exploration behavior (GO:0035640)5.05929323
16regulation of synapse structural plasticity (GO:0051823)4.98720565
17regulation of synaptic vesicle exocytosis (GO:2000300)4.98277248
18protein localization to synapse (GO:0035418)4.96723445
19behavioral response to nicotine (GO:0035095)4.94763656
20synaptic transmission, glutamatergic (GO:0035249)4.57805025
21neurotransmitter-gated ion channel clustering (GO:0072578)4.52526956
22regulation of synaptic vesicle transport (GO:1902803)4.51557757
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.48885840
24dendritic spine morphogenesis (GO:0060997)4.41789600
25layer formation in cerebral cortex (GO:0021819)4.41562175
26glutamate receptor signaling pathway (GO:0007215)4.40186436
27positive regulation of synapse maturation (GO:0090129)4.36059558
28neuron-neuron synaptic transmission (GO:0007270)4.35736289
29neuron cell-cell adhesion (GO:0007158)4.31282825
30G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.27373221
31regulation of dendritic spine morphogenesis (GO:0061001)4.26900705
32regulation of excitatory postsynaptic membrane potential (GO:0060079)4.25858896
33long-term memory (GO:0007616)4.23096744
34positive regulation of membrane potential (GO:0045838)4.22964544
35neurotransmitter secretion (GO:0007269)4.22828640
36regulation of synaptic plasticity (GO:0048167)4.22796608
37behavioral defense response (GO:0002209)4.12375112
38behavioral fear response (GO:0001662)4.12375112
39neuronal action potential propagation (GO:0019227)4.09358527
40regulation of postsynaptic membrane potential (GO:0060078)3.96043029
41long-term synaptic potentiation (GO:0060291)3.90194739
42adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.81445896
43proline transport (GO:0015824)3.80850509
44regulation of female receptivity (GO:0045924)3.78373300
45positive regulation of dendritic spine morphogenesis (GO:0061003)3.77367808
46neuromuscular process controlling balance (GO:0050885)3.75468059
47positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.74189615
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.72038404
49fear response (GO:0042596)3.68940216
50cellular potassium ion homeostasis (GO:0030007)3.63934011
51positive regulation of neurotransmitter secretion (GO:0001956)3.63280286
52neuron recognition (GO:0008038)3.62814258
53dopamine receptor signaling pathway (GO:0007212)3.62547830
54dendritic spine organization (GO:0097061)3.56454827
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.54616535
56positive regulation of dendritic spine development (GO:0060999)3.53083989
57transmission of nerve impulse (GO:0019226)3.52963670
58activation of protein kinase A activity (GO:0034199)3.51635588
59regulation of dendritic spine development (GO:0060998)3.50423529
60synaptic vesicle endocytosis (GO:0048488)3.48915852
61auditory behavior (GO:0031223)3.46864575
62prepulse inhibition (GO:0060134)3.46851642
63innervation (GO:0060384)3.46672308
64axonal fasciculation (GO:0007413)3.46554030
65positive regulation of neurotransmitter transport (GO:0051590)3.46285348
66sodium ion export (GO:0071436)3.43905466
67positive regulation of synaptic transmission, GABAergic (GO:0032230)3.37064776
68female mating behavior (GO:0060180)3.35932969
69synaptic transmission, dopaminergic (GO:0001963)3.35916421
70gamma-aminobutyric acid transport (GO:0015812)3.35900854
71regulation of neurotransmitter secretion (GO:0046928)3.34529906
72neurotransmitter transport (GO:0006836)3.32667217
73regulation of vesicle fusion (GO:0031338)3.32186388
74response to histamine (GO:0034776)3.30034626
75regulation of synapse maturation (GO:0090128)3.29954135
76gamma-aminobutyric acid signaling pathway (GO:0007214)3.28410904
77learning (GO:0007612)3.28054961
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.28044252
79postsynaptic membrane organization (GO:0001941)3.25544894
80membrane depolarization (GO:0051899)3.24187750
81long term synaptic depression (GO:0060292)3.22985189
82regulation of glutamate secretion (GO:0014048)3.18921972
83regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.16725954
84regulation of synaptic transmission (GO:0050804)3.16598103
85regulation of neurotransmitter transport (GO:0051588)3.14241119
86vesicle transport along microtubule (GO:0047496)3.14045285
87regulation of neurotransmitter levels (GO:0001505)3.13482962
88negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12825402
89cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.12519266
90cell communication by electrical coupling (GO:0010644)3.12362360
91maturation of 5.8S rRNA (GO:0000460)3.12186180
92response to auditory stimulus (GO:0010996)3.11300842
93positive regulation of synaptic transmission (GO:0050806)3.11222433
94response to amphetamine (GO:0001975)3.10543492
95dendrite morphogenesis (GO:0048813)3.07221808
96behavioral response to cocaine (GO:0048148)3.06240165
97regulation of mesoderm development (GO:2000380)3.03326649
98negative regulation of activin receptor signaling pathway (GO:0032926)3.03209830
99chemosensory behavior (GO:0007635)3.00570101
100regulation of hippo signaling (GO:0035330)3.00314319
101* synaptic transmission (GO:0007268)2.99660947
102membrane depolarization during action potential (GO:0086010)2.99171765
103clathrin coat assembly (GO:0048268)2.98956522
104membrane hyperpolarization (GO:0060081)2.98247928
105establishment or maintenance of monopolar cell polarity (GO:0061339)2.96072043
106establishment of monopolar cell polarity (GO:0061162)2.96072043
107neuromuscular process (GO:0050905)2.94364937
108establishment of apical/basal cell polarity (GO:0035089)2.90328387
109enteric nervous system development (GO:0048484)2.88277642
110establishment of protein localization to mitochondrial membrane (GO:0090151)2.88235619
111response to gravity (GO:0009629)2.72134905
112negative regulation of telomere maintenance (GO:0032205)2.69323091
113kidney morphogenesis (GO:0060993)2.65857195
114replication fork processing (GO:0031297)2.65080075
115pseudouridine synthesis (GO:0001522)2.63176601
116pattern specification involved in kidney development (GO:0061004)2.62256564
117lateral sprouting from an epithelium (GO:0060601)2.60385101
118negative regulation of axon extension involved in axon guidance (GO:0048843)2.58731387
119regulation of nuclear cell cycle DNA replication (GO:0033262)2.54847191
120termination of RNA polymerase III transcription (GO:0006386)2.54426463
121transcription elongation from RNA polymerase III promoter (GO:0006385)2.54426463
122peptidyl-histidine modification (GO:0018202)2.54234996
123neuron projection extension involved in neuron projection guidance (GO:1902284)2.54009434
124axon extension involved in axon guidance (GO:0048846)2.54009434
125cardiac right ventricle morphogenesis (GO:0003215)2.53952674
126GTP biosynthetic process (GO:0006183)2.50696937
127inner ear receptor cell development (GO:0060119)2.48303172
128positive regulation of gastrulation (GO:2000543)2.47161633
129water-soluble vitamin biosynthetic process (GO:0042364)2.46459290
130urinary tract smooth muscle contraction (GO:0014848)2.43825227
131regulation of gene silencing by RNA (GO:0060966)2.43678944
132regulation of posttranscriptional gene silencing (GO:0060147)2.43678944
133regulation of gene silencing by miRNA (GO:0060964)2.43678944
134DNA deamination (GO:0045006)2.41938585
135detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.38794708
136negative regulation of axon guidance (GO:1902668)2.38478756
137detection of mechanical stimulus involved in sensory perception (GO:0050974)2.38379168
138UTP biosynthetic process (GO:0006228)2.34333933
139anterior/posterior axis specification, embryo (GO:0008595)2.34018507
140establishment of planar polarity (GO:0001736)2.33567404
141establishment of tissue polarity (GO:0007164)2.33567404
142polarized epithelial cell differentiation (GO:0030859)2.32427584
143positive regulation of fatty acid beta-oxidation (GO:0032000)2.31779560
144regulation of action potential (GO:0098900)2.26986048
145outer ear morphogenesis (GO:0042473)2.26758087
146response to pheromone (GO:0019236)2.25957917
147regulation of respiratory system process (GO:0044065)2.24833098
148RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.24787569
149tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.24787569
150positive regulation of action potential (GO:0045760)2.21556472
151G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.21498291
152cell migration in hindbrain (GO:0021535)2.20972048
153hindbrain development (GO:0030902)2.20963524
154notochord development (GO:0030903)2.20880685
155positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.20492399
156positive regulation of cell cycle G2/M phase transition (GO:1902751)2.20492399
157convergent extension (GO:0060026)2.17329629
158neuromuscular synaptic transmission (GO:0007274)2.15749499
159presynaptic membrane assembly (GO:0097105)2.14567043
160regulation of activin receptor signaling pathway (GO:0032925)2.14173071
161nephron tubule morphogenesis (GO:0072078)2.12674863
162nephron epithelium morphogenesis (GO:0072088)2.12674863
163atrial cardiac muscle cell action potential (GO:0086014)2.12065823
164spinal cord development (GO:0021510)2.10300021
165retinal ganglion cell axon guidance (GO:0031290)2.09811174
166behavioral response to ethanol (GO:0048149)2.09612350
167signal transduction involved in regulation of gene expression (GO:0023019)2.08772913
168cellular response to ATP (GO:0071318)2.08594771
169positive regulation of fatty acid oxidation (GO:0046321)2.07496717
170UTP metabolic process (GO:0046051)2.06261061
171kidney mesenchyme development (GO:0072074)2.05735815
172nonmotile primary cilium assembly (GO:0035058)2.05511540
173sympathetic nervous system development (GO:0048485)2.04241864
174neuronal action potential (GO:0019228)2.03017438
175response to BMP (GO:0071772)2.02462637
176cellular response to BMP stimulus (GO:0071773)2.02462637
177dermatan sulfate biosynthetic process (GO:0030208)2.02452777
178fat-soluble vitamin catabolic process (GO:0042363)2.01777343
179vitamin catabolic process (GO:0009111)2.01777343
180inner ear receptor stereocilium organization (GO:0060122)2.01682596
181regulation of axon extension involved in axon guidance (GO:0048841)2.01624128
182regulation of mitochondrial translation (GO:0070129)2.01527205
183planar cell polarity pathway involved in neural tube closure (GO:0090179)2.01401440
184tRNA processing (GO:0008033)2.00813805
185dopaminergic neuron differentiation (GO:0071542)1.99890474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.91842640
2* RARB_27405468_Chip-Seq_BRAIN_Mouse3.56908597
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.38582516
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.29931801
5GBX2_23144817_ChIP-Seq_PC3_Human3.18791190
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.18165565
7* REST_21632747_ChIP-Seq_MESCs_Mouse3.12287336
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.92224763
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.91332533
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.91332533
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.90500207
12DROSHA_22980978_ChIP-Seq_HELA_Human2.79489013
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.77666468
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.66462598
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.64062750
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63574695
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.60155134
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54730931
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.51143351
20* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.46753234
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.46077032
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.41957814
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40485975
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.37711402
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37522191
26* RNF2_27304074_Chip-Seq_ESCs_Mouse2.31836798
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30592249
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22018145
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.15232039
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05086516
31VDR_22108803_ChIP-Seq_LS180_Human2.03541178
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02072302
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90759029
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.85527114
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.73659743
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68659746
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64902540
38AR_21572438_ChIP-Seq_LNCaP_Human1.59886833
39TP53_20018659_ChIP-ChIP_R1E_Mouse1.59300607
40* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.56668314
41MYC_18940864_ChIP-ChIP_HL60_Human1.54608689
42SMAD4_21799915_ChIP-Seq_A2780_Human1.53875514
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51690283
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.51147478
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50554405
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50340611
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48013289
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.46048734
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40752355
50ZNF274_21170338_ChIP-Seq_K562_Hela1.40643641
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39355101
52KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39355101
53KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39355101
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37776511
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35550262
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.32827750
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32657459
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31925787
59KDM2B_26808549_Chip-Seq_K562_Human1.28724074
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28107953
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26186705
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26185121
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24797498
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24512966
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.23874778
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23670394
67* RING1B_27294783_Chip-Seq_NPCs_Mouse1.22286400
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22121607
69* AR_19668381_ChIP-Seq_PC3_Human1.22051701
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.21733014
71IRF1_19129219_ChIP-ChIP_H3396_Human1.18430550
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17428275
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.16266748
74SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15828858
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15218368
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14474283
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12570952
78TAF15_26573619_Chip-Seq_HEK293_Human1.12412459
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11456836
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.11316821
81KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11090827
82AR_25329375_ChIP-Seq_VCAP_Human1.10999094
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10864864
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10278324
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09546855
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.09323240
87* P300_19829295_ChIP-Seq_ESCs_Human1.08383474
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08214086
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07330234
90CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06902833
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06352952
92CTCF_27219007_Chip-Seq_Bcells_Human1.06111513
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06066484
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05490568
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.04873229
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04156183
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03256335
98SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02697202
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01773217
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00188749
101STAT3_23295773_ChIP-Seq_U87_Human0.99649396
102* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99589767
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99350882
104* TET1_21490601_ChIP-Seq_MESCs_Mouse0.98882642
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98402571
106THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98087930
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.97175247
108* ERA_21632823_ChIP-Seq_H3396_Human0.95332224
109CBX2_27304074_Chip-Seq_ESCs_Mouse0.95063383
110EWS_26573619_Chip-Seq_HEK293_Human0.93624184
111KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93393469
112EST1_17652178_ChIP-ChIP_JURKAT_Human0.93257935
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92594917
114JUN_21703547_ChIP-Seq_K562_Human0.92580951
115SMAD_19615063_ChIP-ChIP_OVARY_Human0.92167909
116ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90982101
117TCF4_23295773_ChIP-Seq_U87_Human0.90599085
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.90128555
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89519242
120NANOG_16153702_ChIP-ChIP_HESCs_Human0.88187240
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87726481
122TP53_22573176_ChIP-Seq_HFKS_Human0.87542471
123POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87015645
124ARNT_22903824_ChIP-Seq_MCF-7_Human0.86744518
125FUS_26573619_Chip-Seq_HEK293_Human0.86032363
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85093536
127RNF2_27304074_Chip-Seq_NSC_Mouse0.84929869
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.84723461
129TP53_22127205_ChIP-Seq_IMR90_Human0.84512616
130YY1_21170310_ChIP-Seq_MESCs_Mouse0.83399667
131RUNX2_22187159_ChIP-Seq_PCA_Human0.81536297
132XRN2_22483619_ChIP-Seq_HELA_Human0.81058342
133BMI1_23680149_ChIP-Seq_NPCS_Mouse0.80449313
134LXR_22292898_ChIP-Seq_THP-1_Human0.79168862
135* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78665772
136KDM2B_26808549_Chip-Seq_JURKAT_Human0.78510922
137TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.78340053
138FOXP1_21924763_ChIP-Seq_HESCs_Human0.78070396
139TET1_21451524_ChIP-Seq_MESCs_Mouse0.77794629
140TBX3_20139965_ChIP-Seq_MESCs_Mouse0.76990337
141TBX3_20139965_ChIP-Seq_ESCs_Mouse0.76763074
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.76637868
143IGF1R_20145208_ChIP-Seq_DFB_Human0.76509597
144CTCF_20526341_ChIP-Seq_ESCs_Human0.76367061
145SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.75772561
146KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.75502989
147GABP_19822575_ChIP-Seq_HepG2_Human0.75008350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.84564027
2MP0003880_abnormal_central_pattern4.86105059
3MP0003635_abnormal_synaptic_transmissio4.58897617
4MP0002822_catalepsy4.16618787
5MP0002063_abnormal_learning/memory/cond3.73419841
6MP0004270_analgesia3.72854010
7MP0009745_abnormal_behavioral_response3.62484237
8MP0002064_seizures3.22611589
9MP0002572_abnormal_emotion/affect_behav2.91496832
10MP0009046_muscle_twitch2.87028767
11MP0001968_abnormal_touch/_nociception2.70355111
12MP0004133_heterotaxia2.67340089
13MP0001486_abnormal_startle_reflex2.52755975
14MP0005423_abnormal_somatic_nervous2.52237706
15MP0002272_abnormal_nervous_system2.49453275
16MP0010030_abnormal_orbit_morphology2.49114467
17MP0002734_abnormal_mechanical_nocicepti2.29298604
18MP0002735_abnormal_chemical_nociception2.19274400
19MP0001501_abnormal_sleep_pattern2.17508562
20MP0003136_yellow_coat_color2.16682297
21MP0001984_abnormal_olfaction2.15412415
22MP0001440_abnormal_grooming_behavior2.13609579
23MP0002736_abnormal_nociception_after2.05036334
24MP0004811_abnormal_neuron_physiology2.00811188
25MP0002909_abnormal_adrenal_gland1.99492891
26MP0003329_amyloid_beta_deposits1.98740614
27MP0009780_abnormal_chondrocyte_physiolo1.96184085
28MP0004924_abnormal_behavior1.86494183
29MP0005386_behavior/neurological_phenoty1.86494183
30MP0002733_abnormal_thermal_nociception1.82722804
31MP0004858_abnormal_nervous_system1.82404582
32MP0000778_abnormal_nervous_system1.81646515
33MP0002638_abnormal_pupillary_reflex1.78814570
34MP0001970_abnormal_pain_threshold1.78657218
35MP0000537_abnormal_urethra_morphology1.76500849
36MP0008569_lethality_at_weaning1.72047161
37MP0002184_abnormal_innervation1.70442537
38MP0002557_abnormal_social/conspecific_i1.70258295
39MP0002067_abnormal_sensory_capabilities1.67099228
40MP0003890_abnormal_embryonic-extraembry1.65017745
41MP0003937_abnormal_limbs/digits/tail_de1.60706138
42MP0003879_abnormal_hair_cell1.58901076
43MP0000049_abnormal_middle_ear1.52943481
44MP0002102_abnormal_ear_morphology1.50303968
45MP0001529_abnormal_vocalization1.50169447
46MP0002751_abnormal_autonomic_nervous1.49350004
47MP0002938_white_spotting1.48643146
48MP0000955_abnormal_spinal_cord1.48618542
49MP0010386_abnormal_urinary_bladder1.45789758
50MP0005646_abnormal_pituitary_gland1.39543574
51MP0002882_abnormal_neuron_morphology1.39072407
52MP0002066_abnormal_motor_capabilities/c1.38901543
53MP0006292_abnormal_olfactory_placode1.37610730
54MP0003075_altered_response_to1.35400984
55MP0000569_abnormal_digit_pigmentation1.34760359
56MP0001905_abnormal_dopamine_level1.34520520
57MP0002160_abnormal_reproductive_system1.34335364
58MP0009250_abnormal_appendicular_skeleto1.33244990
59MP0004885_abnormal_endolymph1.30556672
60MP0003942_abnormal_urinary_system1.27930206
61MP0003787_abnormal_imprinting1.26794148
62MP0003633_abnormal_nervous_system1.23727308
63MP0000538_abnormal_urinary_bladder1.23392703
64MP0000579_abnormal_nail_morphology1.22137733
65MP0006276_abnormal_autonomic_nervous1.21401952
66MP0002152_abnormal_brain_morphology1.19165632
67MP0009384_cardiac_valve_regurgitation1.17332383
68MP0000762_abnormal_tongue_morphology1.14403514
69MP0000427_abnormal_hair_cycle1.13075009
70MP0003755_abnormal_palate_morphology1.10088912
71MP0003631_nervous_system_phenotype1.09713908
72MP0010234_abnormal_vibrissa_follicle1.09281872
73MP0000534_abnormal_ureter_morphology1.08873046
74MP0008872_abnormal_physiological_respon1.06822630
75MP0002163_abnormal_gland_morphology1.03895199
76MP0008874_decreased_physiological_sensi1.03642218
77MP0002932_abnormal_joint_morphology1.01766032
78MP0009053_abnormal_anal_canal1.01100310
79MP0003693_abnormal_embryo_hatching1.00684235
80MP0005645_abnormal_hypothalamus_physiol1.00564474
81MP0000462_abnormal_digestive_system0.97912035
82MP0006072_abnormal_retinal_apoptosis0.97037101
83MP0002697_abnormal_eye_size0.96767860
84MP0003385_abnormal_body_wall0.96535556
85MP0002111_abnormal_tail_morphology0.94934514
86MP0000604_amyloidosis0.91231430
87MP0000751_myopathy0.91015587
88MP0005499_abnormal_olfactory_system0.90756656
89MP0005394_taste/olfaction_phenotype0.90756656
90MP0000026_abnormal_inner_ear0.90727180
91MP0004272_abnormal_basement_membrane0.90653710
92MP0003121_genomic_imprinting0.89975084
93MP0002069_abnormal_eating/drinking_beha0.89932817
94MP0003283_abnormal_digestive_organ0.89198327
95MP0004142_abnormal_muscle_tone0.88735947
96MP0005623_abnormal_meninges_morphology0.88497706
97MP0001286_abnormal_eye_development0.88327462
98MP0008961_abnormal_basal_metabolism0.87740164
99MP0001188_hyperpigmentation0.86854342
100MP0008438_abnormal_cutaneous_collagen0.86804736
101MP0001299_abnormal_eye_distance/0.85590018
102MP0001177_atelectasis0.85307831
103MP0005389_reproductive_system_phenotype0.84425120
104MP0005409_darkened_coat_color0.82784523
105MP0003122_maternal_imprinting0.81333465
106MP0002254_reproductive_system_inflammat0.79759705
107MP0001502_abnormal_circadian_rhythm0.79358497
108MP0003941_abnormal_skin_development0.78930228
109MP0004085_abnormal_heartbeat0.78477102
110MP0000428_abnormal_craniofacial_morphol0.77994504
111MP0001346_abnormal_lacrimal_gland0.77849804
112MP0002282_abnormal_trachea_morphology0.77821631
113MP0000647_abnormal_sebaceous_gland0.77441252
114MP0003634_abnormal_glial_cell0.77259425
115MP0003632_abnormal_nervous_system0.77089641
116MP0009379_abnormal_foot_pigmentation0.76748674
117MP0002116_abnormal_craniofacial_bone0.75306463
118MP0002233_abnormal_nose_morphology0.75298198
119MP0002229_neurodegeneration0.74736179
120MP0003935_abnormal_craniofacial_develop0.73842834
121MP0001293_anophthalmia0.72479686
122MP0003315_abnormal_perineum_morphology0.72256123
123MP0004233_abnormal_muscle_weight0.71958307
124MP0003718_maternal_effect0.71724413
125MP0003938_abnormal_ear_development0.71542758
126MP0003861_abnormal_nervous_system0.69480207
127MP0005535_abnormal_body_temperature0.67202412
128MP0003690_abnormal_glial_cell0.65098335
129MP0002752_abnormal_somatic_nervous0.64801836
130MP0001963_abnormal_hearing_physiology0.63313769
131MP0000631_abnormal_neuroendocrine_gland0.61579065
132MP0001664_abnormal_digestion0.60851140
133MP0002876_abnormal_thyroid_physiology0.60216542
134MP0008877_abnormal_DNA_methylation0.59469426
135MP0004484_altered_response_of0.58767632
136MP0004510_myositis0.58075116
137MP0003123_paternal_imprinting0.57983189
138MP0005166_decreased_susceptibility_to0.56296241
139MP0003172_abnormal_lysosome_physiology0.56094689
140MP0002090_abnormal_vision0.56053478
141MP0005551_abnormal_eye_electrophysiolog0.55550746
142MP0010769_abnormal_survival0.54310426
143MP0001485_abnormal_pinna_reflex0.53708956
144MP0003956_abnormal_body_size0.52280063
145MP0000920_abnormal_myelination0.51565270
146MP0005187_abnormal_penis_morphology0.51197884
147MP0002082_postnatal_lethality0.51067055
148MP0010770_preweaning_lethality0.51067055
149MP0002653_abnormal_ependyma_morphology0.51060887
150MP0010768_mortality/aging0.50777083
151MP0003119_abnormal_digestive_system0.50647458
152MP0004145_abnormal_muscle_electrophysio0.48927685
153MP0002234_abnormal_pharynx_morphology0.48479764

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.34803943
2Focal motor seizures (HP:0011153)7.66219058
3Visual hallucinations (HP:0002367)5.95504421
4Focal seizures (HP:0007359)5.93687477
5Epileptic encephalopathy (HP:0200134)4.91214084
6Papilledema (HP:0001085)4.67946618
7Progressive cerebellar ataxia (HP:0002073)3.83953090
8Poor eye contact (HP:0000817)3.78261688
9Abnormality of the lower motor neuron (HP:0002366)3.72521793
10Absence seizures (HP:0002121)3.71909415
11Generalized tonic-clonic seizures (HP:0002069)3.67380767
12Atonic seizures (HP:0010819)3.65868711
13Impaired vibration sensation in the lower limbs (HP:0002166)3.65427079
14Febrile seizures (HP:0002373)3.62067033
15Action tremor (HP:0002345)3.56033103
16Amblyopia (HP:0000646)3.54938929
17Dialeptic seizures (HP:0011146)3.50132369
18Broad-based gait (HP:0002136)3.44649810
19Supranuclear gaze palsy (HP:0000605)3.37867715
20Depression (HP:0000716)3.35375882
21Torticollis (HP:0000473)3.30785574
22Abnormal social behavior (HP:0012433)3.28469507
23Impaired social interactions (HP:0000735)3.28469507
24Type II lissencephaly (HP:0007260)3.27402904
25Ankle clonus (HP:0011448)3.25879804
26Focal dystonia (HP:0004373)3.18018127
27Anxiety (HP:0000739)3.09720534
28Annular pancreas (HP:0001734)3.09297569
29Postural instability (HP:0002172)3.08847138
30Mutism (HP:0002300)3.08798352
31Concave nail (HP:0001598)3.06051696
32Urinary bladder sphincter dysfunction (HP:0002839)3.04354457
33Gaze-evoked nystagmus (HP:0000640)2.97640836
34Stereotypic behavior (HP:0000733)2.91322751
35Dysmetria (HP:0001310)2.88654663
36Hyperventilation (HP:0002883)2.86932280
37Molar tooth sign on MRI (HP:0002419)2.83144855
38Abnormality of midbrain morphology (HP:0002418)2.83144855
39Amyotrophic lateral sclerosis (HP:0007354)2.78777018
40Craniofacial dystonia (HP:0012179)2.78575301
41Cerebral inclusion bodies (HP:0100314)2.76715465
42Bilateral microphthalmos (HP:0007633)2.73031206
43Pancreatic cysts (HP:0001737)2.72541540
44Dysdiadochokinesis (HP:0002075)2.72525908
45Truncal ataxia (HP:0002078)2.72042275
46Impaired smooth pursuit (HP:0007772)2.72040727
47Pointed chin (HP:0000307)2.69858575
48Megalencephaly (HP:0001355)2.67287773
49Urinary urgency (HP:0000012)2.66215051
50Ankyloglossia (HP:0010296)2.64957311
51Abnormal eating behavior (HP:0100738)2.62231411
52Esophageal atresia (HP:0002032)2.61889647
53Bradykinesia (HP:0002067)2.60607649
54Epileptiform EEG discharges (HP:0011182)2.60187155
55Increased corneal curvature (HP:0100692)2.58531440
56Keratoconus (HP:0000563)2.58531440
57Pancreatic fibrosis (HP:0100732)2.58071072
58Obstructive sleep apnea (HP:0002870)2.55051435
59Excessive salivation (HP:0003781)2.52109830
60Drooling (HP:0002307)2.52109830
61Sclerocornea (HP:0000647)2.51171401
62EEG with generalized epileptiform discharges (HP:0011198)2.50574879
63Hypsarrhythmia (HP:0002521)2.45456773
64Delusions (HP:0000746)2.45301087
65True hermaphroditism (HP:0010459)2.43448023
66Diplopia (HP:0000651)2.43262429
67Abnormality of binocular vision (HP:0011514)2.43262429
68Nephronophthisis (HP:0000090)2.41754585
69Septo-optic dysplasia (HP:0100842)2.38978041
70Cerebellar dysplasia (HP:0007033)2.36704051
71Insomnia (HP:0100785)2.35233795
72Anophthalmia (HP:0000528)2.35057553
73Spastic gait (HP:0002064)2.34615291
74Abnormality of ocular smooth pursuit (HP:0000617)2.32714009
75Impaired vibratory sensation (HP:0002495)2.31034999
76Microretrognathia (HP:0000308)2.30174957
77Genetic anticipation (HP:0003743)2.28368533
78Abnormality of oral frenula (HP:0000190)2.27968545
79Hemiparesis (HP:0001269)2.26215670
80Rib fusion (HP:0000902)2.25969128
81Premature rupture of membranes (HP:0001788)2.23082931
82Hemiplegia (HP:0002301)2.22262454
83Apathy (HP:0000741)2.19754480
84Anterior segment dysgenesis (HP:0007700)2.19368849
85Occipital encephalocele (HP:0002085)2.18830699
86Chorioretinal atrophy (HP:0000533)2.18171561
87Hypoventilation (HP:0002791)2.17991133
88Intention tremor (HP:0002080)2.16829463
89Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14553687
90Resting tremor (HP:0002322)2.13424152
91Ventricular fibrillation (HP:0001663)2.12329657
92Neurofibrillary tangles (HP:0002185)2.11736423
93Anencephaly (HP:0002323)2.10834221
94Congenital stationary night blindness (HP:0007642)2.09188688
95Tubular atrophy (HP:0000092)2.08431161
96Pendular nystagmus (HP:0012043)2.07455098
97Generalized myoclonic seizures (HP:0002123)2.06750960
98Hypoplasia of the pons (HP:0012110)2.06582601
99Optic nerve hypoplasia (HP:0000609)2.06328769
100Rapidly progressive (HP:0003678)2.05341436
101Incomplete penetrance (HP:0003829)2.04963473
102Genu recurvatum (HP:0002816)2.04756078
103Termporal pattern (HP:0011008)2.03505192
104Insidious onset (HP:0003587)2.03505192
105Bundle branch block (HP:0011710)2.03326066
106Gastrointestinal atresia (HP:0002589)2.02466729
107Follicular hyperkeratosis (HP:0007502)2.02298727
108Absent speech (HP:0001344)2.01722868
109Abnormality of the phalanges of the 2nd finger (HP:0009541)2.01198116
110Fetal akinesia sequence (HP:0001989)2.01083901
111Inappropriate behavior (HP:0000719)2.00415821
112Progressive inability to walk (HP:0002505)2.00242702
113Abnormality of the pons (HP:0007361)1.99844657
114Inability to walk (HP:0002540)1.99251591
115Fragile nails (HP:0001808)1.97769240
116Dysmetric saccades (HP:0000641)1.96861757
117Lower limb asymmetry (HP:0100559)1.95231412
118Limb dystonia (HP:0002451)1.92704675
119Diminished motivation (HP:0000745)1.90518036
120Large for gestational age (HP:0001520)1.90320633
121Aplasia/Hypoplasia of the patella (HP:0006498)1.89335154
122Patellar aplasia (HP:0006443)1.88055003
123Lower limb amyotrophy (HP:0007210)1.87698688
124Cystic liver disease (HP:0006706)1.86938831
125Severe muscular hypotonia (HP:0006829)1.86674207
126Scanning speech (HP:0002168)1.86252174
127Lower limb muscle weakness (HP:0007340)1.86048238
128Maternal diabetes (HP:0009800)1.85300736
129Abdominal situs inversus (HP:0003363)1.81363839
130Abnormality of abdominal situs (HP:0011620)1.81363839
131Intestinal atresia (HP:0011100)1.81222092
132Abnormality of the renal medulla (HP:0100957)1.79212532
133Abnormality of dentin (HP:0010299)1.79129505
134Abnormality of the periventricular white matter (HP:0002518)1.78358731
135Status epilepticus (HP:0002133)1.77448278
136Intellectual disability, profound (HP:0002187)1.77299727
137Truncus arteriosus (HP:0001660)1.77144218
138Retinal dysplasia (HP:0007973)1.76028931
139Absent/shortened dynein arms (HP:0200106)1.75975588
140Dynein arm defect of respiratory motile cilia (HP:0012255)1.75975588
141Lissencephaly (HP:0001339)1.75832133
142Generalized hypotonia (HP:0001290)1.75507254
143Gait ataxia (HP:0002066)1.74433665
144Abnormal number of incisors (HP:0011064)1.74330648
145Abnormal EKG (HP:0003115)1.74098495
146Abnormality of the corticospinal tract (HP:0002492)1.73233201
147Birth length less than 3rd percentile (HP:0003561)1.72389570
148Patent foramen ovale (HP:0001655)1.72269912
149Bronchomalacia (HP:0002780)1.72026081
150Clonus (HP:0002169)1.70766993
151Abnormality of the middle phalanges of the toes (HP:0010183)1.67988812
152Aplasia/hypoplasia of the uterus (HP:0008684)1.67448191
153Soft skin (HP:0000977)1.67073442
154Sleep apnea (HP:0010535)1.65726881
155Rigidity (HP:0002063)1.64645844
156Abnormality of the aortic arch (HP:0012303)1.64494675
157Hypoplasia of the ulna (HP:0003022)1.63884217
158Short hallux (HP:0010109)1.63801542
159Non-midline cleft lip (HP:0100335)1.63047717
160Breast hypoplasia (HP:0003187)1.61773582
161Absent thumb (HP:0009777)1.60737984
162Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.60037641
163Absent epiphyses (HP:0010577)1.60037641
164Ulnar claw (HP:0001178)1.59995813
165Breast aplasia (HP:0100783)1.59723209
166Congenital, generalized hypertrichosis (HP:0004540)1.58810438
167Polydipsia (HP:0001959)1.58096752
168Abnormal drinking behavior (HP:0030082)1.58096752
169Medial flaring of the eyebrow (HP:0010747)1.57988799
170Morphological abnormality of the middle ear (HP:0008609)1.57214768
171Redundant skin (HP:0001582)1.55815685
172Aplasia/Hypoplasia of the breasts (HP:0010311)1.55604967
173Brittle hair (HP:0002299)1.55342407
174Aplasia/Hypoplasia of the hallux (HP:0008362)1.54903360
175Abnormality of the phalanges of the 5th finger (HP:0004213)1.54656113
176Hypoplasia of the uterus (HP:0000013)1.54375103
177Preaxial foot polydactyly (HP:0001841)1.53984258
178Flat capital femoral epiphysis (HP:0003370)1.52845688
179Horseshoe kidney (HP:0000085)1.50223322
180Abnormality of the 2nd finger (HP:0004100)1.49259682
181Abnormal number of erythroid precursors (HP:0012131)1.49204760
182Aplasia/Hypoplasia of the ulna (HP:0006495)1.48522316
183Abolished electroretinogram (ERG) (HP:0000550)1.48394347
184Clumsiness (HP:0002312)1.48175036
185Male pseudohermaphroditism (HP:0000037)1.47210863
186Gait imbalance (HP:0002141)1.44193027
187Delayed gross motor development (HP:0002194)1.43079030
188Disproportionate short-trunk short stature (HP:0003521)1.42823928
189Furrowed tongue (HP:0000221)1.42004824
190Small hand (HP:0200055)1.41540390
191Dandy-Walker malformation (HP:0001305)1.41389826
192Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.40342448
193Renal duplication (HP:0000075)1.39525939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.36751924
2NTRK34.79519751
3MAP3K94.26867225
4MINK13.02365533
5ZAK2.77010820
6KSR22.76751054
7WNK42.72871458
8DAPK22.71020502
9MARK12.65782634
10FRK2.49398271
11ADRBK22.49332274
12MAP3K42.37178501
13BMPR1B2.36333265
14TLK12.31138687
15ARAF2.22289403
16EPHA22.18867415
17PRKD32.18036407
18KSR12.17174006
19CAMKK12.15811763
20DAPK12.15119502
21PAK62.04281985
22GRK12.04246832
23RIPK42.00286453
24MAP3K131.96527858
25MAP2K71.91182298
26VRK21.88962956
27EPHB21.82941779
28NTRK21.82478001
29MAP2K41.80226012
30MAPK151.74711083
31PLK21.65656602
32WNK31.61842773
33DYRK21.60317295
34MAP4K21.56609202
35FES1.56495432
36INSRR1.54595328
37CDK51.52092532
38WEE11.50219796
39MAP3K21.47370843
40STK38L1.42490299
41RAF11.41088311
42GRK51.40629611
43PTK2B1.37596007
44MAP3K121.35740982
45LATS21.33285196
46LIMK11.32791651
47MET1.32475380
48PRPF4B1.31773496
49SIK21.29320108
50NTRK11.28334334
51BUB11.27917207
52CAMKK21.26252856
53STK381.23308872
54TNIK1.22399666
55PRKCG1.21405500
56ADRBK11.16912632
57MAPK131.16509136
58CDK191.14757606
59PNCK1.13478598
60MKNK21.13048877
61NUAK11.10107600
62VRK11.09038378
63TYRO31.08583659
64TAOK11.04004890
65CAMK11.03661459
66CDK180.99897393
67CDK150.97037440
68STK110.97005952
69UHMK10.95860302
70CDK140.95111288
71PRKCI0.94725053
72MAP3K100.94353923
73FLT30.94288974
74PRKD20.91806035
75NEK20.90415984
76ACVR1B0.88228161
77ILK0.87382428
78CAMK2A0.85566887
79ALK0.85105123
80CDK11A0.85093799
81PHKG20.84795296
82PHKG10.84795296
83MAP3K60.83912588
84NEK10.82235632
85TRIB30.81248225
86LATS10.80073804
87MAP2K20.79899283
88PRKCE0.77854570
89TGFBR10.77597844
90PDK10.76037160
91CAMK2B0.73925064
92CHEK20.72025486
93BRSK10.71504490
94TSSK60.71341095
95CSNK1G30.67694077
96TAF10.66960278
97PTK20.66854357
98MARK20.66722930
99SCYL20.66534389
100DYRK1A0.65296101
101CCNB10.64565150
102CASK0.63926689
103CSNK1G10.63609878
104NME20.63498710
105PAK40.59676159
106PRKCH0.59652849
107MAPKAPK30.59295991
108PDPK10.58504978
109DMPK0.58478976
110RET0.57458988
111MUSK0.57289693
112RPS6KA60.56541573
113PAK30.55764625
114GRK60.55534328
115SGK10.54861643
116STK390.54622062
117AURKA0.54129639
118ERBB40.53259444
119BRAF0.53233140
120MAP3K10.52972021
121CAMK1D0.52547296
122PKN10.50381362
123BMPR20.49557335
124TRIM280.49530994
125LMTK20.48188576
126FGR0.47988255
127PIM20.47597438
128CSNK1A1L0.46670173
129DYRK30.46280438
130SGK4940.46274156
131SGK2230.46274156
132RPS6KA20.45990838
133PRKCZ0.45886855
134MAP2K60.45258556
135RPS6KA30.44597410
136DAPK30.44299720
137MAP3K70.43972599
138FYN0.42228678
139MAP2K10.40573686
140CAMK40.40534281
141PINK10.39746505
142MAPK120.38276973
143CSNK1G20.37055427
144MAPK100.36668497
145NME10.35172798
146SGK20.32568507
147SGK30.31039886
148MOS0.29736485
149PLK30.27913843
150OXSR10.27468927
151PRKCB0.27454370
152CAMK2G0.24698550
153CSNK1E0.23396635
154CAMK2D0.22149868
155PRKCA0.20655529

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.86618337
2Nicotine addiction_Homo sapiens_hsa050333.49159173
3Synaptic vesicle cycle_Homo sapiens_hsa047213.09480632
4Long-term potentiation_Homo sapiens_hsa047203.07925408
5Circadian entrainment_Homo sapiens_hsa047132.91374466
6Amphetamine addiction_Homo sapiens_hsa050312.79294185
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63274403
8Morphine addiction_Homo sapiens_hsa050322.54207614
9Glutamatergic synapse_Homo sapiens_hsa047242.53708357
10GABAergic synapse_Homo sapiens_hsa047272.52663268
11RNA polymerase_Homo sapiens_hsa030202.51282945
12Dopaminergic synapse_Homo sapiens_hsa047282.37388182
13Selenocompound metabolism_Homo sapiens_hsa004502.26152516
14Salivary secretion_Homo sapiens_hsa049702.18580254
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.17062881
16Sulfur relay system_Homo sapiens_hsa041222.09290462
17Aldosterone synthesis and secretion_Homo sapiens_hsa049252.04409554
18Cholinergic synapse_Homo sapiens_hsa047252.03874656
19Gastric acid secretion_Homo sapiens_hsa049711.99939177
20Basal cell carcinoma_Homo sapiens_hsa052171.95943447
21Insulin secretion_Homo sapiens_hsa049111.92469336
22Oxidative phosphorylation_Homo sapiens_hsa001901.91611721
23Oxytocin signaling pathway_Homo sapiens_hsa049211.81972719
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73713325
25Renin secretion_Homo sapiens_hsa049241.73286815
26Calcium signaling pathway_Homo sapiens_hsa040201.71557379
27Cocaine addiction_Homo sapiens_hsa050301.69998750
28Hedgehog signaling pathway_Homo sapiens_hsa043401.66678071
29Hippo signaling pathway_Homo sapiens_hsa043901.64938248
30Long-term depression_Homo sapiens_hsa047301.64578125
31GnRH signaling pathway_Homo sapiens_hsa049121.61137077
32Taste transduction_Homo sapiens_hsa047421.54057629
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52820698
34Vitamin B6 metabolism_Homo sapiens_hsa007501.52065004
35Ribosome_Homo sapiens_hsa030101.51651906
36Parkinsons disease_Homo sapiens_hsa050121.51305526
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48151671
38Homologous recombination_Homo sapiens_hsa034401.47928963
39Gap junction_Homo sapiens_hsa045401.46917326
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45698860
41Serotonergic synapse_Homo sapiens_hsa047261.45185734
42Protein export_Homo sapiens_hsa030601.42783344
43Glioma_Homo sapiens_hsa052141.42578396
44cAMP signaling pathway_Homo sapiens_hsa040241.39376944
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38539899
46Basal transcription factors_Homo sapiens_hsa030221.37087899
47One carbon pool by folate_Homo sapiens_hsa006701.37060396
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34819912
49Oocyte meiosis_Homo sapiens_hsa041141.34131694
50Huntingtons disease_Homo sapiens_hsa050161.31364678
51Fanconi anemia pathway_Homo sapiens_hsa034601.29754099
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26543842
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24485245
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23535617
55Estrogen signaling pathway_Homo sapiens_hsa049151.23511222
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21070706
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.20558373
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20462379
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16611739
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15891903
61Pyrimidine metabolism_Homo sapiens_hsa002401.12724762
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12430993
63TGF-beta signaling pathway_Homo sapiens_hsa043501.12247043
64Melanogenesis_Homo sapiens_hsa049161.12172099
65Collecting duct acid secretion_Homo sapiens_hsa049661.11289348
66Type II diabetes mellitus_Homo sapiens_hsa049301.07216216
67ErbB signaling pathway_Homo sapiens_hsa040121.05482239
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04736151
69Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01944055
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01020866
71Axon guidance_Homo sapiens_hsa043600.99049389
72Linoleic acid metabolism_Homo sapiens_hsa005910.98975875
73RNA degradation_Homo sapiens_hsa030180.98840753
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.96082112
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92137697
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91878131
77ECM-receptor interaction_Homo sapiens_hsa045120.90339084
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.90191247
79VEGF signaling pathway_Homo sapiens_hsa043700.88870025
80Purine metabolism_Homo sapiens_hsa002300.88780514
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.87676105
82Dorso-ventral axis formation_Homo sapiens_hsa043200.84856825
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.82593216
84Melanoma_Homo sapiens_hsa052180.81008525
85Protein digestion and absorption_Homo sapiens_hsa049740.80431886
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79629251
87Cardiac muscle contraction_Homo sapiens_hsa042600.78326534
88Nucleotide excision repair_Homo sapiens_hsa034200.75830544
89Thyroid hormone synthesis_Homo sapiens_hsa049180.75197365
90Choline metabolism in cancer_Homo sapiens_hsa052310.74742772
91Ether lipid metabolism_Homo sapiens_hsa005650.73379887
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72640752
93RNA transport_Homo sapiens_hsa030130.71958139
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71531113
95Nitrogen metabolism_Homo sapiens_hsa009100.71430793
96Phototransduction_Homo sapiens_hsa047440.70420489
97Vibrio cholerae infection_Homo sapiens_hsa051100.70232928
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69409240
99MAPK signaling pathway_Homo sapiens_hsa040100.69272466
100Glucagon signaling pathway_Homo sapiens_hsa049220.69085931
101Proteasome_Homo sapiens_hsa030500.68939986
102Non-small cell lung cancer_Homo sapiens_hsa052230.68565473
103N-Glycan biosynthesis_Homo sapiens_hsa005100.67746591
104Butanoate metabolism_Homo sapiens_hsa006500.67648772
105Pancreatic secretion_Homo sapiens_hsa049720.66916567
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66751135
107Alcoholism_Homo sapiens_hsa050340.65775270
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64971833
109Sulfur metabolism_Homo sapiens_hsa009200.63294434
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63077388
111Arginine and proline metabolism_Homo sapiens_hsa003300.60346081
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60234422
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.59249237
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57211870
115Rap1 signaling pathway_Homo sapiens_hsa040150.56546258
116mTOR signaling pathway_Homo sapiens_hsa041500.55837374
117Metabolic pathways_Homo sapiens_hsa011000.54117085
118p53 signaling pathway_Homo sapiens_hsa041150.53873650
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53216784
120Prion diseases_Homo sapiens_hsa050200.52655798
121Ras signaling pathway_Homo sapiens_hsa040140.52568552
122Folate biosynthesis_Homo sapiens_hsa007900.51728287
123Tight junction_Homo sapiens_hsa045300.51036789
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49484361
125Dilated cardiomyopathy_Homo sapiens_hsa054140.49420153
126Vitamin digestion and absorption_Homo sapiens_hsa049770.49210405
127Tryptophan metabolism_Homo sapiens_hsa003800.48759676
128African trypanosomiasis_Homo sapiens_hsa051430.46442111
129Endometrial cancer_Homo sapiens_hsa052130.46153960
130Wnt signaling pathway_Homo sapiens_hsa043100.44160477
131Ovarian steroidogenesis_Homo sapiens_hsa049130.43681356
132Spliceosome_Homo sapiens_hsa030400.43340120
133Endocytosis_Homo sapiens_hsa041440.42838728
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42281490
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42073003
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.40727056
137Insulin signaling pathway_Homo sapiens_hsa049100.40682525
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40286037
139Colorectal cancer_Homo sapiens_hsa052100.38249691
140Peroxisome_Homo sapiens_hsa041460.37797154
141Chemokine signaling pathway_Homo sapiens_hsa040620.37479697
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.36981652
143beta-Alanine metabolism_Homo sapiens_hsa004100.36967269
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36208293
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36075645
146Renal cell carcinoma_Homo sapiens_hsa052110.32886038
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32565645
148Bile secretion_Homo sapiens_hsa049760.31121032
149B cell receptor signaling pathway_Homo sapiens_hsa046620.28601012
150Inositol phosphate metabolism_Homo sapiens_hsa005620.28223261
151Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28163262
152Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27873339
153Platelet activation_Homo sapiens_hsa046110.26790839
154Type I diabetes mellitus_Homo sapiens_hsa049400.24867730
155Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.22111726
156HIF-1 signaling pathway_Homo sapiens_hsa040660.21332136
157Alzheimers disease_Homo sapiens_hsa050100.20478996
158Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19672189

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