KCNA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac muscle adaptation (GO:0014887)5.47823517
2cardiac muscle hypertrophy in response to stress (GO:0014898)5.47823517
3muscle hypertrophy in response to stress (GO:0003299)5.47823517
4* negative regulation of cytosolic calcium ion concentration (GO:0051481)5.17304747
5cardiac myofibril assembly (GO:0055003)4.94819064
6regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.86024584
7cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.60976141
8muscle hypertrophy (GO:0014896)4.48778754
9sarcomere organization (GO:0045214)4.48211008
10regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.45013911
11detection of light stimulus involved in visual perception (GO:0050908)4.43701144
12detection of light stimulus involved in sensory perception (GO:0050962)4.43701144
13regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.36689937
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.33676646
15positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.31355520
16cardiac muscle contraction (GO:0060048)4.28543808
17regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.23181228
18myofibril assembly (GO:0030239)4.22675537
19negative regulation of potassium ion transmembrane transport (GO:1901380)4.20001261
20striatum development (GO:0021756)4.12854797
21cell communication by electrical coupling (GO:0010644)4.09444298
22cellular ketone body metabolic process (GO:0046950)4.00544072
23cell communication involved in cardiac conduction (GO:0086065)3.96289053
24negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.95407128
25regulation of synapse structural plasticity (GO:0051823)3.89174528
26* regulation of membrane repolarization (GO:0060306)3.86684071
27inositol phosphate catabolic process (GO:0071545)3.75486649
28inositol phosphate dephosphorylation (GO:0046855)3.70860371
29phosphorylated carbohydrate dephosphorylation (GO:0046838)3.70860371
30epithelial cell fate commitment (GO:0072148)3.70573580
31cellular potassium ion homeostasis (GO:0030007)3.70509679
32retinal rod cell development (GO:0046548)3.65549162
33auditory receptor cell differentiation (GO:0042491)3.63275827
34ventricular cardiac muscle cell action potential (GO:0086005)3.60032000
35regulation of cell communication by electrical coupling (GO:0010649)3.59462482
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.57478886
37regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.57318483
38sensory perception of smell (GO:0007608)3.52793377
39ketone body metabolic process (GO:1902224)3.49306185
40regulation of cardioblast differentiation (GO:0051890)3.48321736
41plasma membrane repair (GO:0001778)3.46861823
42negative regulation of hormone biosynthetic process (GO:0032353)3.46175813
43positive regulation of potassium ion transmembrane transport (GO:1901381)3.44815341
44insulin secretion (GO:0030073)3.43898874
45glycerophospholipid catabolic process (GO:0046475)3.43602221
46muscle filament sliding (GO:0030049)3.42247955
47actin-myosin filament sliding (GO:0033275)3.42247955
48sodium ion export (GO:0071436)3.39745944
49regulation of skeletal muscle contraction (GO:0014819)3.39608235
50striated muscle contraction (GO:0006941)3.31885939
51neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.31563242
52regulation of actin filament-based movement (GO:1903115)3.29597106
53regulation of sarcomere organization (GO:0060297)3.28728435
54regulation of voltage-gated calcium channel activity (GO:1901385)3.26513857
55detection of calcium ion (GO:0005513)3.26408730
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.25413505
57regulation of type B pancreatic cell apoptotic process (GO:2000674)3.24612984
58regulation of short-term neuronal synaptic plasticity (GO:0048172)3.23778273
59potassium ion import (GO:0010107)3.23401287
60ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.18849242
61regulation of relaxation of muscle (GO:1901077)3.17833431
62tricarboxylic acid cycle (GO:0006099)3.17749735
63regulation of the force of heart contraction (GO:0002026)3.16749261
64positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.16671854
65receptor guanylyl cyclase signaling pathway (GO:0007168)3.15593575
66* regulation of heart rate by cardiac conduction (GO:0086091)3.14892691
67activation of protein kinase A activity (GO:0034199)3.13212345
68actomyosin structure organization (GO:0031032)3.12678564
69synaptic vesicle maturation (GO:0016188)3.11648562
70adult heart development (GO:0007512)3.07774590
71cardiac muscle tissue morphogenesis (GO:0055008)3.07643913
72regulation of calcium ion transmembrane transporter activity (GO:1901019)3.07473728
73regulation of calcium ion transmembrane transport (GO:1903169)3.07473728
74regulation of secondary heart field cardioblast proliferation (GO:0003266)3.06312635
75regulation of cardioblast proliferation (GO:0003264)3.06312635
76* cardiac conduction (GO:0061337)3.05373724
77membrane depolarization during action potential (GO:0086010)3.05165057
78* cardiac muscle cell action potential (GO:0086001)3.05135779
79membrane repolarization (GO:0086009)3.04919271
80cardiac muscle cell development (GO:0055013)3.04585676
81synaptic vesicle exocytosis (GO:0016079)3.02844095
82relaxation of smooth muscle (GO:0044557)3.00379415
83positive regulation of potassium ion transport (GO:0043268)2.99957693
84regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.99671064
85respiratory chain complex IV assembly (GO:0008535)2.98784309
86negative regulation of hormone metabolic process (GO:0032351)2.96162506
87striated muscle adaptation (GO:0014888)2.96028060
88actin-mediated cell contraction (GO:0070252)2.93866551
89* cardiac muscle cell action potential involved in contraction (GO:0086002)2.93856360
90heart trabecula formation (GO:0060347)2.92582660
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91337032
92cardiac cell development (GO:0055006)2.91120207
93cardiac muscle hypertrophy (GO:0003300)2.91093112
94* regulation of heart rate (GO:0002027)2.91001262
95response to inactivity (GO:0014854)2.90933055
96proline transport (GO:0015824)2.90914043
97urinary tract smooth muscle contraction (GO:0014848)2.90236397
98rhodopsin mediated signaling pathway (GO:0016056)2.90070172
99* potassium ion homeostasis (GO:0055075)2.89156426
100regulation of striated muscle contraction (GO:0006942)2.88944703
101cytochrome complex assembly (GO:0017004)2.88543226
102membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.87343698
103dentate gyrus development (GO:0021542)2.86889728
104relaxation of cardiac muscle (GO:0055119)2.86414590
105positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.85494339
106regulation of hexokinase activity (GO:1903299)2.82926983
107regulation of glucokinase activity (GO:0033131)2.82926983
108mating behavior (GO:0007617)2.80539969
109response to pheromone (GO:0019236)2.79761892
110regulation of cardiac muscle contraction (GO:0055117)2.79694885
111G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79567645
112negative regulation of calcium ion transmembrane transport (GO:1903170)2.78892639
113negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.78892639
114prepulse inhibition (GO:0060134)2.78067075
115sarcoplasmic reticulum calcium ion transport (GO:0070296)2.77841886
116cGMP biosynthetic process (GO:0006182)2.77374208
117muscle tissue morphogenesis (GO:0060415)2.76980462
118endocrine pancreas development (GO:0031018)2.76694844
119nitric oxide mediated signal transduction (GO:0007263)2.76155294
120striated muscle hypertrophy (GO:0014897)2.76049767
121response to caffeine (GO:0031000)2.75519221
122regulation of rhodopsin mediated signaling pathway (GO:0022400)2.74473932
123behavioral response to cocaine (GO:0048148)2.72748349
124regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.72259769
125retinal cone cell development (GO:0046549)2.72029829
126growth hormone secretion (GO:0030252)2.71319775
127adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.70561974
128positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.70512012
129protein localization to synapse (GO:0035418)2.70122155
130ventricular cardiac muscle cell development (GO:0055015)2.70038753
131regulation of potassium ion transmembrane transport (GO:1901379)2.69618763
132regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.67978597
133synaptic transmission, dopaminergic (GO:0001963)2.67958524
134dendritic spine morphogenesis (GO:0060997)2.67506809
135peptide hormone processing (GO:0016486)2.66002381
136somite rostral/caudal axis specification (GO:0032525)2.65967034
137nephron epithelium morphogenesis (GO:0072088)2.64952510
138nephron tubule morphogenesis (GO:0072078)2.64952510
139regulation of execution phase of apoptosis (GO:1900117)2.63241717
140positive regulation of sodium ion transport (GO:0010765)2.63203447
141positive regulation of gluconeogenesis (GO:0045722)2.61584513
142renal tubule morphogenesis (GO:0061333)2.61128275
143polyol catabolic process (GO:0046174)2.60224745
144negative regulation of execution phase of apoptosis (GO:1900118)2.57876569
145positive regulation of insulin secretion (GO:0032024)2.57835801
146positive regulation of neurotransmitter transport (GO:0051590)2.56690756
147regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.56397838
148adult feeding behavior (GO:0008343)2.54393652
149positive regulation of cardiac muscle tissue growth (GO:0055023)2.51281406
150positive regulation of action potential (GO:0045760)2.50833779
151negative regulation of cardiac muscle hypertrophy (GO:0010614)2.45739709
152regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.44164617
153regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.44164617
154positive regulation of heart rate (GO:0010460)2.43742010
155regulation of neurotransmitter uptake (GO:0051580)2.43516967
156cardiac chamber formation (GO:0003207)2.43274589
157calcium ion import (GO:0070509)2.42605038
158muscle adaptation (GO:0043500)2.42566036
159positive regulation of heart growth (GO:0060421)2.41882831
160positive regulation of cardiac muscle cell proliferation (GO:0060045)2.40371006

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.27163413
2EZH2_22144423_ChIP-Seq_EOC_Human3.41592094
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73159085
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.57549495
5DROSHA_22980978_ChIP-Seq_HELA_Human2.54952457
6GBX2_23144817_ChIP-Seq_PC3_Human2.53706377
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41267506
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41267506
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40600945
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.37823666
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.35608010
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32227780
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30720367
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.29711136
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28744443
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24573768
17IGF1R_20145208_ChIP-Seq_DFB_Human2.24081113
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20493694
19EP300_21415370_ChIP-Seq_HL-1_Mouse2.19782989
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14525102
21* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11218475
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.07299570
23* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00950990
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98851439
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.98292835
26* RNF2_27304074_Chip-Seq_ESCs_Mouse1.89875627
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88171418
28ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.86195269
29REST_21632747_ChIP-Seq_MESCs_Mouse1.80126984
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77904273
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71062623
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.61055137
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.56727236
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56651009
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.54960074
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50346407
37FUS_26573619_Chip-Seq_HEK293_Human1.50343443
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48289200
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46390874
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45513744
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44545151
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44507774
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44060048
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43625296
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42337190
46* TBX20_22328084_ChIP-Seq_HEART_Mouse1.42201667
47* TBX20_22080862_ChIP-Seq_HEART_Mouse1.42201667
48AR_21572438_ChIP-Seq_LNCaP_Human1.40636676
49TAF15_26573619_Chip-Seq_HEK293_Human1.37714632
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.37527768
51HTT_18923047_ChIP-ChIP_STHdh_Human1.37129474
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34695108
53RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34617067
54SMAD4_21799915_ChIP-Seq_A2780_Human1.33091852
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32328084
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32196012
57TCF4_23295773_ChIP-Seq_U87_Human1.29956555
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.29332984
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28487290
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.28439750
61P53_22127205_ChIP-Seq_FIBROBLAST_Human1.27543759
62KDM2B_26808549_Chip-Seq_K562_Human1.26465339
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24988075
64* CTCF_27219007_Chip-Seq_Bcells_Human1.24155104
65ZNF263_19887448_ChIP-Seq_K562_Human1.23824462
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23553531
67ER_23166858_ChIP-Seq_MCF-7_Human1.23527115
68TCF4_22108803_ChIP-Seq_LS180_Human1.23333871
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22503001
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21662567
71RNF2_27304074_Chip-Seq_NSC_Mouse1.21496379
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21291646
73* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19960634
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.19053357
75* SMAD4_21741376_ChIP-Seq_HESCs_Human1.19032193
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18964540
77SMAD3_21741376_ChIP-Seq_HESCs_Human1.18740063
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.18581534
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.18177365
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17243583
81AR_19668381_ChIP-Seq_PC3_Human1.17116700
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.16858923
83P53_22387025_ChIP-Seq_ESCs_Mouse1.16094345
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16008265
85ZNF274_21170338_ChIP-Seq_K562_Hela1.15875079
86* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15569890
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.15161484
88EWS_26573619_Chip-Seq_HEK293_Human1.14471861
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14198915
90SOX2_18555785_Chip-Seq_ESCs_Mouse1.13773327
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13664380
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13498029
93TRIM28_21343339_ChIP-Seq_HEK293_Human1.11256866
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10909597
95MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.10885876
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.10783527
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.10553136
98TP53_22573176_ChIP-Seq_HFKS_Human1.10493998
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10430742
100NANOG_19829295_ChIP-Seq_ESCs_Human1.09651218
101SOX2_19829295_ChIP-Seq_ESCs_Human1.09651218
102* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09316637
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.09246424
104CDX2_22108803_ChIP-Seq_LS180_Human1.08876841
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07886359
106EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07361743
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06088113
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.05980961
109CMYC_18555785_Chip-Seq_ESCs_Mouse1.05539787
110RING1B_27294783_Chip-Seq_NPCs_Mouse1.05425254
111SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05298635
112* RUNX2_22187159_ChIP-Seq_PCA_Human1.04931036
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03980847
114CBP_20019798_ChIP-Seq_JUKART_Human1.02917923
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02917923
116AHR_22903824_ChIP-Seq_MCF-7_Human1.02698380
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.02045855
118TBL1_22424771_ChIP-Seq_293T_Human1.01917381
119EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01433391
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01398903
121SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00863828
122TAL1_26923725_Chip-Seq_HPCs_Mouse1.00187065
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98961871
124CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98629769
125GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97608990
126ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97210243
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96946754
128ISL1_27105846_Chip-Seq_CPCs_Mouse0.95093772
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94477673
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93597676
131DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93458198
132P300_19829295_ChIP-Seq_ESCs_Human0.93333526
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93277625
134STAT3_23295773_ChIP-Seq_U87_Human0.93057791
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93001418
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.92631594
137BCAT_22108803_ChIP-Seq_LS180_Human0.92427102
138RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92379656
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92235005
140OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91902480
141KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91300053
142* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89936829
143VDR_22108803_ChIP-Seq_LS180_Human0.89930143
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89236231
145WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88665608
146AR_25329375_ChIP-Seq_VCAP_Human0.88607321
147YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87734408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.35366109
2MP0004215_abnormal_myocardial_fiber4.06350730
3MP0000751_myopathy3.88863332
4MP0004084_abnormal_cardiac_muscle3.85887331
5MP0001984_abnormal_olfaction3.51106248
6MP0002822_catalepsy3.34422478
7MP0004036_abnormal_muscle_relaxation3.26927401
8MP0003646_muscle_fatigue3.25326660
9MP0005551_abnormal_eye_electrophysiolog3.24733788
10MP0003195_calcinosis2.98933044
11MP0005379_endocrine/exocrine_gland_phen2.48602634
12MP0005330_cardiomyopathy2.48446976
13MP0003137_abnormal_impulse_conducting2.38985342
14MP0006054_spinal_hemorrhage2.38231484
15MP0006072_abnormal_retinal_apoptosis2.37677447
16MP0000749_muscle_degeneration2.35591835
17MP0010234_abnormal_vibrissa_follicle2.32500708
18MP0008775_abnormal_heart_ventricle2.26112629
19MP0004145_abnormal_muscle_electrophysio2.17625231
20MP0004233_abnormal_muscle_weight2.11541622
21MP0004085_abnormal_heartbeat2.08820726
22MP0002972_abnormal_cardiac_muscle2.08299065
23MP0000013_abnormal_adipose_tissue2.08110094
24* MP0005620_abnormal_muscle_contractility2.07483675
25MP0003787_abnormal_imprinting2.00192243
26MP0004130_abnormal_muscle_cell1.94984185
27MP0002090_abnormal_vision1.93009428
28MP0004087_abnormal_muscle_fiber1.92754988
29MP0002163_abnormal_gland_morphology1.88717767
30MP0003950_abnormal_plasma_membrane1.87074692
31MP0003880_abnormal_central_pattern1.85382695
32MP0005253_abnormal_eye_physiology1.84436318
33MP0001944_abnormal_pancreas_morphology1.82370719
34MP0010368_abnormal_lymphatic_system1.79396865
35MP0002332_abnormal_exercise_endurance1.77022396
36MP0002693_abnormal_pancreas_physiology1.74580101
37MP0004859_abnormal_synaptic_plasticity1.70787395
38MP0004270_analgesia1.68669437
39MP0005670_abnormal_white_adipose1.66960917
40MP0002909_abnormal_adrenal_gland1.61556805
41MP0001544_abnormal_cardiovascular_syste1.58223905
42MP0005385_cardiovascular_system_phenoty1.58223905
43* MP0003635_abnormal_synaptic_transmissio1.57427777
44MP0004484_altered_response_of1.55379186
45MP0002106_abnormal_muscle_physiology1.53497928
46MP0008877_abnormal_DNA_methylation1.50185612
47MP0010630_abnormal_cardiac_muscle1.50097002
48MP0005423_abnormal_somatic_nervous1.47954228
49MP0006138_congestive_heart_failure1.47820601
50MP0001502_abnormal_circadian_rhythm1.46511160
51MP0001486_abnormal_startle_reflex1.45017165
52MP0002254_reproductive_system_inflammat1.44098564
53MP0000750_abnormal_muscle_regeneration1.41002548
54MP0002269_muscular_atrophy1.40855811
55MP0005646_abnormal_pituitary_gland1.40424992
56MP0000003_abnormal_adipose_tissue1.39377126
57MP0002127_abnormal_cardiovascular_syste1.36979449
58MP0005220_abnormal_exocrine_pancreas1.35775934
59MP0002638_abnormal_pupillary_reflex1.34265628
60MP0002139_abnormal_hepatobiliary_system1.33741137
61MP0000747_muscle_weakness1.32575054
62MP0009745_abnormal_behavioral_response1.31059489
63MP0001661_extended_life_span1.28519202
64MP0005369_muscle_phenotype1.27515307
65MP0000759_abnormal_skeletal_muscle1.27164915
66MP0002063_abnormal_learning/memory/cond1.27135609
67MP0003283_abnormal_digestive_organ1.26734288
68MP0001529_abnormal_vocalization1.26120135
69MP0005195_abnormal_posterior_eye1.25973364
70MP0003011_delayed_dark_adaptation1.24959055
71MP0002876_abnormal_thyroid_physiology1.24563943
72MP0002064_seizures1.24490820
73MP0002078_abnormal_glucose_homeostasis1.24291569
74* MP0002272_abnormal_nervous_system1.22656261
75MP0004510_myositis1.22431345
76MP0005084_abnormal_gallbladder_morpholo1.18776519
77MP0005499_abnormal_olfactory_system1.15140909
78MP0005394_taste/olfaction_phenotype1.15140909
79MP0002734_abnormal_mechanical_nocicepti1.15096005
80MP0000372_irregular_coat_pigmentation1.12484946
81MP0005375_adipose_tissue_phenotype1.12224217
82MP0009046_muscle_twitch1.11785872
83MP0004924_abnormal_behavior1.11448618
84MP0005386_behavior/neurological_phenoty1.11448618
85MP0005623_abnormal_meninges_morphology1.09828888
86MP0004885_abnormal_endolymph1.09630693
87MP0001879_abnormal_lymphatic_vessel1.06017989
88MP0002184_abnormal_innervation1.05259820
89MP0002572_abnormal_emotion/affect_behav1.04158910
90MP0002234_abnormal_pharynx_morphology1.03082890
91MP0003122_maternal_imprinting1.01944022
92MP0005332_abnormal_amino_acid1.01711859
93MP0005666_abnormal_adipose_tissue1.01642259
94MP0001905_abnormal_dopamine_level1.00168939
95MP0003121_genomic_imprinting1.00117738
96MP0001756_abnormal_urination0.98995960
97MP0002229_neurodegeneration0.98948359
98MP0001968_abnormal_touch/_nociception0.98760231
99MP0003123_paternal_imprinting0.98439458
100MP0008961_abnormal_basal_metabolism0.98164958
101MP0002733_abnormal_thermal_nociception0.97611761
102MP0005448_abnormal_energy_balance0.96042806
103MP0004272_abnormal_basement_membrane0.95796687
104MP0002752_abnormal_somatic_nervous0.94356678
105MP0010329_abnormal_lipoprotein_level0.94199035
106MP0002067_abnormal_sensory_capabilities0.93764539
107MP0003221_abnormal_cardiomyocyte_apopto0.93389437
108MP0000230_abnormal_systemic_arterial0.92715106
109MP0000516_abnormal_urinary_system0.92573958
110MP0005367_renal/urinary_system_phenotyp0.92573958
111MP0008789_abnormal_olfactory_epithelium0.92060745
112MP0005645_abnormal_hypothalamus_physiol0.91000203
113MP0002882_abnormal_neuron_morphology0.87858953
114MP0002295_abnormal_pulmonary_circulatio0.86572068
115MP0003828_pulmonary_edema0.86469517
116MP0005167_abnormal_blood-brain_barrier0.86088850
117MP0009780_abnormal_chondrocyte_physiolo0.85770001
118MP0001501_abnormal_sleep_pattern0.84774807
119MP0004043_abnormal_pH_regulation0.83159884
120MP0004142_abnormal_muscle_tone0.83079983
121MP0003953_abnormal_hormone_level0.81522851
122MP0004019_abnormal_vitamin_homeostasis0.78724578
123MP0000631_abnormal_neuroendocrine_gland0.78478422
124MP0006036_abnormal_mitochondrial_physio0.77057615
125MP0002557_abnormal_social/conspecific_i0.75818578
126MP0008569_lethality_at_weaning0.75101554
127MP0002108_abnormal_muscle_morphology0.75089184
128MP0005248_abnormal_Harderian_gland0.74708331
129MP0003279_aneurysm0.74459799
130MP0005165_increased_susceptibility_to0.72746490
131MP0010386_abnormal_urinary_bladder0.72326408
132MP0006276_abnormal_autonomic_nervous0.69585927
133MP0000266_abnormal_heart_morphology0.67109992
134MP0003633_abnormal_nervous_system0.66692764
135* MP0005595_abnormal_vascular_smooth0.66490644
136MP0005535_abnormal_body_temperature0.65838141
137MP0001970_abnormal_pain_threshold0.64734144
138MP0003879_abnormal_hair_cell0.64215254

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.48784354
2Central scotoma (HP:0000603)6.19768940
3Sudden death (HP:0001699)5.71613641
4* Atrial fibrillation (HP:0005110)5.00315710
5Exercise-induced myalgia (HP:0003738)4.87562902
6Double outlet right ventricle (HP:0001719)4.78699590
7Congenital malformation of the right heart (HP:0011723)4.78699590
8* Primary atrial arrhythmia (HP:0001692)4.76559637
9Scotoma (HP:0000575)4.65239097
10Abnormality of macular pigmentation (HP:0008002)4.60162815
11* Supraventricular tachycardia (HP:0004755)4.54947186
12* Supraventricular arrhythmia (HP:0005115)4.51090021
13Exercise-induced muscle cramps (HP:0003710)4.47035504
14* Prolonged QT interval (HP:0001657)4.43759326
15Calf muscle hypertrophy (HP:0008981)4.35796576
16Syncope (HP:0001279)4.35244341
17Ventricular tachycardia (HP:0004756)4.34758209
18Muscle fiber splitting (HP:0003555)4.08539928
19Muscle hypertrophy of the lower extremities (HP:0008968)4.00128923
20Abnormality of the calf musculature (HP:0001430)3.96135341
21Abnormal rod and cone electroretinograms (HP:0008323)3.80609109
22Ventricular fibrillation (HP:0001663)3.65500577
23Hypoglycemic coma (HP:0001325)3.65174569
24Severe visual impairment (HP:0001141)3.62759639
25Myoglobinuria (HP:0002913)3.59730842
26Bony spicule pigmentary retinopathy (HP:0007737)3.58613647
27Lipoatrophy (HP:0100578)3.51459407
28* Abnormal EKG (HP:0003115)3.40881539
29Hyporeflexia of lower limbs (HP:0002600)3.32498376
30Hyperglycemia (HP:0003074)3.27163591
31Bundle branch block (HP:0011710)3.09439515
32Left ventricular hypertrophy (HP:0001712)3.07895921
33Ventricular arrhythmia (HP:0004308)3.06752195
34* Palpitations (HP:0001962)3.03700974
35Dilated cardiomyopathy (HP:0001644)3.02187837
36Abnormality of vitamin B metabolism (HP:0004340)3.00659087
37Abnormal pancreas size (HP:0012094)2.99679409
38EMG: myopathic abnormalities (HP:0003458)2.94007163
39Hemiparesis (HP:0001269)2.93518837
40Hypothermia (HP:0002045)2.91864039
41Abnormality of aromatic amino acid family metabolism (HP:0004338)2.90767811
42Methylmalonic acidemia (HP:0002912)2.84620017
43Decreased central vision (HP:0007663)2.84319330
44Right ventricular cardiomyopathy (HP:0011663)2.81960921
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.80732006
46Hypoglycemic seizures (HP:0002173)2.78253849
47Heart block (HP:0012722)2.75528899
48Increased CSF protein (HP:0002922)2.74730914
49Myokymia (HP:0002411)2.74712757
50Difficulty running (HP:0009046)2.74145322
51Myotonia (HP:0002486)2.72653201
52Subaortic stenosis (HP:0001682)2.71058102
53Abnormality of the left ventricular outflow tract (HP:0011103)2.71058102
54Vascular calcification (HP:0004934)2.69107229
55Enlarged penis (HP:0000040)2.65711352
56Atrioventricular block (HP:0001678)2.65290863
57Pigmentary retinal degeneration (HP:0001146)2.64849800
58Increased circulating renin level (HP:0000848)2.63362524
59Abnormality of vitamin metabolism (HP:0100508)2.58315777
60Glycosuria (HP:0003076)2.54999718
61Abnormality of urine glucose concentration (HP:0011016)2.54999718
62Abnormal atrioventricular conduction (HP:0005150)2.53331353
63Intestinal atresia (HP:0011100)2.53225161
64Keratoconus (HP:0000563)2.48760556
65Increased corneal curvature (HP:0100692)2.48760556
66Late onset (HP:0003584)2.47026487
67Hypomagnesemia (HP:0002917)2.46949277
68Increased variability in muscle fiber diameter (HP:0003557)2.45300100
69Abolished electroretinogram (ERG) (HP:0000550)2.40481576
70Chorioretinal atrophy (HP:0000533)2.38035563
71Febrile seizures (HP:0002373)2.36379783
72Proximal tubulopathy (HP:0000114)2.36058878
73Pheochromocytoma (HP:0002666)2.35722970
74Methylmalonic aciduria (HP:0012120)2.35568545
75Asymmetric septal hypertrophy (HP:0001670)2.34500514
76Insulin-resistant diabetes mellitus (HP:0000831)2.31475798
77Prominent supraorbital ridges (HP:0000336)2.31118545
78Ketosis (HP:0001946)2.30791116
79Increased connective tissue (HP:0009025)2.28179673
80Cardiovascular calcification (HP:0011915)2.27246872
81Polyphagia (HP:0002591)2.26597130
82Absence seizures (HP:0002121)2.22988229
83Agitation (HP:0000713)2.22330817
84Neuroendocrine neoplasm (HP:0100634)2.20223892
85Hepatic necrosis (HP:0002605)2.20081578
86Postural tremor (HP:0002174)2.19965691
87Visual hallucinations (HP:0002367)2.17359503
88Epileptic encephalopathy (HP:0200134)2.16955441
89Muscle stiffness (HP:0003552)2.16404627
90Abnormal drinking behavior (HP:0030082)2.15041975
91Polydipsia (HP:0001959)2.15041975
92Rhabdomyolysis (HP:0003201)2.11370525
93Dicarboxylic aciduria (HP:0003215)2.09488516
94Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09488516
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.07003646
96Difficulty climbing stairs (HP:0003551)2.05284354
97Testicular neoplasm (HP:0010788)2.05249291
98Anxiety (HP:0000739)2.03202267
99Dysmetric saccades (HP:0000641)2.02809653
100Dyschromatopsia (HP:0007641)2.02648467
101Abnormality of skeletal muscle fiber size (HP:0012084)2.02449292
102Pendular nystagmus (HP:0012043)2.01434492
103Abnormal mitochondria in muscle tissue (HP:0008316)2.00522935
104Aplasia/Hypoplasia of the fovea (HP:0008060)1.98683884
105Hypoplasia of the fovea (HP:0007750)1.98683884
106Focal motor seizures (HP:0011153)1.98393344
107Depression (HP:0000716)1.97539401
108Tongue fasciculations (HP:0001308)1.96213289
109Attenuation of retinal blood vessels (HP:0007843)1.95195310
110Hematochezia (HP:0002573)1.94916640
111Hyperventilation (HP:0002883)1.92671704
112Ketoacidosis (HP:0001993)1.92499496
113Muscle fibrillation (HP:0010546)1.89792583
114Atonic seizures (HP:0010819)1.89028947
115Renal cortical cysts (HP:0000803)1.88901956
116Mitochondrial inheritance (HP:0001427)1.88589464
117Abnormality of magnesium homeostasis (HP:0004921)1.87499614
118Acute necrotizing encephalopathy (HP:0006965)1.86458128
119Large for gestational age (HP:0001520)1.85087846
120Athetosis (HP:0002305)1.84792911
121Hypoplastic left heart (HP:0004383)1.84494050
122EEG with generalized epileptiform discharges (HP:0011198)1.83601421
123Abnormality of renal excretion (HP:0011036)1.83147050
124Gaze-evoked nystagmus (HP:0000640)1.83056249
125Hyperphosphatemia (HP:0002905)1.82511181
126Limb-girdle muscle atrophy (HP:0003797)1.82467398
127Neoplasm of the adrenal gland (HP:0100631)1.82217247
128Epileptiform EEG discharges (HP:0011182)1.80799351
129Fetal akinesia sequence (HP:0001989)1.80334179
130Medial flaring of the eyebrow (HP:0010747)1.78517316
131Polyuria (HP:0000103)1.78216398
132Truncus arteriosus (HP:0001660)1.77525657
133Optic disc pallor (HP:0000543)1.76972823
134Hamartoma of the eye (HP:0010568)1.76062487
135Abnormality of the renal cortex (HP:0011035)1.75958486
136Bradycardia (HP:0001662)1.75757544
137Abnormality of calcium-phosphate metabolism (HP:0100530)1.74218236
138Type 1 muscle fiber predominance (HP:0003803)1.74070139
139Rimmed vacuoles (HP:0003805)1.73394428
140Abnormality of the foot musculature (HP:0001436)1.72857971
141Poor suck (HP:0002033)1.72103196
142Dialeptic seizures (HP:0011146)1.71469291
143Type II diabetes mellitus (HP:0005978)1.69335229
144Dysdiadochokinesis (HP:0002075)1.68863220
145Focal seizures (HP:0007359)1.68504080
146Retinal dysplasia (HP:0007973)1.66627716
147Foot dorsiflexor weakness (HP:0009027)1.66579888
148Generalized tonic-clonic seizures (HP:0002069)1.66573473
149Progressive macrocephaly (HP:0004481)1.65673722
150Muscular dystrophy (HP:0003560)1.65578000
151Torticollis (HP:0000473)1.63550470
152Rapidly progressive (HP:0003678)1.60180187
153Lower limb amyotrophy (HP:0007210)1.59656868
154Abnormality of the vocal cords (HP:0008777)1.54961405
155Pancreatic islet-cell hyperplasia (HP:0004510)1.53983408
156Broad metatarsal (HP:0001783)1.52830778
157Ragged-red muscle fibers (HP:0003200)1.51987092
158Palmoplantar keratoderma (HP:0000982)1.51935352
159Distal lower limb amyotrophy (HP:0008944)1.51520022
160Hyperinsulinemic hypoglycemia (HP:0000825)1.50721834

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.52915046
2PHKG23.96082463
3PHKG13.96082463
4TTN3.47463992
5MAP4K23.14521946
6MYLK3.00749727
7LMTK22.86915642
8EPHA42.72476910
9TIE12.54721880
10RIPK12.44369589
11FGFR22.38204402
12OBSCN2.36346268
13NEK12.13455095
14DMPK2.06667106
15PAK61.99206264
16PINK11.97481309
17TNIK1.92707711
18MST41.87973088
19CAMK2D1.77148010
20TRPM71.70451243
21PAK31.69165607
22PRKD31.64215730
23BMPR1B1.52484696
24NLK1.44484818
25TRIB31.41395069
26ERBB31.41343757
27PRPF4B1.37706010
28MAP3K41.36487542
29BCKDK1.33186119
30PKN21.32545765
31CASK1.27048708
32PDK41.25750058
33PDK31.25750058
34PRKG21.25337843
35STK381.21683005
36MINK11.20727614
37MUSK1.19038641
38CAMKK11.18245455
39CAMK1G1.17388325
40FGFR31.17369213
41NTRK31.17316803
42GRK11.17288838
43MAP2K61.16612704
44INSRR1.15346421
45MAP3K91.12962898
46MAP3K71.08930065
47CAMK11.08556356
48STK391.07286760
49MARK11.06808668
50KSR21.05780225
51PRKD11.03613270
52CAMK1D1.03064108
53CDC42BPA1.02751779
54CAMK2A1.02560662
55KSR11.01909400
56PRKAA11.01702860
57PLK21.00118321
58ADRBK20.95425352
59MAP3K120.94487064
60NTRK20.93606012
61OXSR10.93130569
62ROCK10.92030985
63PIK3CA0.90831315
64SGK4940.90062223
65SGK2230.90062223
66ARAF0.89668458
67ACVR1B0.89083963
68CSNK1G10.88580740
69PKN10.88250103
70LIMK10.87661905
71PRKCG0.87381141
72CAMK2G0.85550912
73GRK70.83906831
74TAF10.82447736
75ROCK20.81872254
76PRKCH0.81846167
77FER0.79639135
78KDR0.79261403
79PTK2B0.78568976
80CAMK2B0.77869495
81PRKAA20.77143846
82MARK20.76837373
83CAMKK20.76704539
84CAMK40.75779519
85CDK50.75401570
86EPHB20.74785878
87WNK10.74395732
88MAPK130.74027005
89MAPK120.73558850
90DAPK20.72796394
91STK38L0.72440252
92STK160.71810617
93TAOK10.70633444
94PDK20.70037195
95MAPK150.69550998
96WNK30.65925437
97SIK20.65630819
98PRKCE0.64062952
99MAP2K40.63971707
100WNK40.63513918
101FLT30.62478212
102STK240.59650195
103DAPK30.59160686
104DYRK1A0.58826612
105ILK0.58661707
106PRKD20.57716556
107SGK20.56857991
108CSNK1G20.56238260
109MAP3K130.56083144
110NUAK10.55450330
111PRKACA0.55006853
112PNCK0.54836740
113PRKCQ0.54593007
114UHMK10.53488149
115STK110.52158585
116NTRK10.51716414
117CSNK1G30.51495501
118STK30.51353622
119PDGFRA0.50319627
120SGK10.50219302
121SGK30.50190376
122ZAK0.48537222
123PRKACG0.47232188
124RPS6KA30.46180267
125FES0.45823561
126GRK50.44721910
127PRKG10.44357183
128NME10.44138311
129MAP3K10.44012737
130ICK0.43836257
131IRAK20.43515267
132MAP2K70.42830863
133PRKACB0.41878828
134TNK20.41801170
135PRKCI0.41349285
136RAF10.40761621
137EPHA30.36736508
138PRKCZ0.36436896
139ADRBK10.34810960
140HIPK20.33222238
141IRAK10.32975065

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.40109639
2Olfactory transduction_Homo sapiens_hsa047403.39184053
3Phototransduction_Homo sapiens_hsa047443.25192687
4Cardiac muscle contraction_Homo sapiens_hsa042603.07919617
5Dilated cardiomyopathy_Homo sapiens_hsa054142.79041371
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.77481246
7GABAergic synapse_Homo sapiens_hsa047272.42696629
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.41914728
9Protein export_Homo sapiens_hsa030602.32281166
10Morphine addiction_Homo sapiens_hsa050322.24240789
11Circadian entrainment_Homo sapiens_hsa047132.17454288
12Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.05903149
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.03580086
14Nicotine addiction_Homo sapiens_hsa050331.96601342
15Folate biosynthesis_Homo sapiens_hsa007901.95537969
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.92348842
17Synaptic vesicle cycle_Homo sapiens_hsa047211.92204560
18Renin secretion_Homo sapiens_hsa049241.90597629
19Insulin secretion_Homo sapiens_hsa049111.83640690
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72243140
21Parkinsons disease_Homo sapiens_hsa050121.69777047
22Cholinergic synapse_Homo sapiens_hsa047251.65994629
23Oxytocin signaling pathway_Homo sapiens_hsa049211.58788671
24Glutamatergic synapse_Homo sapiens_hsa047241.51997025
25cGMP-PKG signaling pathway_Homo sapiens_hsa040221.50635343
26Salivary secretion_Homo sapiens_hsa049701.50419468
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48422727
28Oxidative phosphorylation_Homo sapiens_hsa001901.47704620
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.45767734
30Dopaminergic synapse_Homo sapiens_hsa047281.45237607
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44688049
32Calcium signaling pathway_Homo sapiens_hsa040201.40501274
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33659977
34Sulfur metabolism_Homo sapiens_hsa009201.33436860
35Alzheimers disease_Homo sapiens_hsa050101.33153732
36Circadian rhythm_Homo sapiens_hsa047101.31516747
37Gastric acid secretion_Homo sapiens_hsa049711.30631851
38Propanoate metabolism_Homo sapiens_hsa006401.30605573
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26792557
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.26565224
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26104383
42cAMP signaling pathway_Homo sapiens_hsa040241.25934457
43Tryptophan metabolism_Homo sapiens_hsa003801.24114541
44Serotonergic synapse_Homo sapiens_hsa047261.22975143
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20422286
46Gap junction_Homo sapiens_hsa045401.17916338
47Taste transduction_Homo sapiens_hsa047421.14430004
48Cocaine addiction_Homo sapiens_hsa050301.13784462
49Ether lipid metabolism_Homo sapiens_hsa005651.11590650
50Amphetamine addiction_Homo sapiens_hsa050311.11476058
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04922281
52beta-Alanine metabolism_Homo sapiens_hsa004101.04459746
53Fatty acid elongation_Homo sapiens_hsa000620.98680809
54Carbon metabolism_Homo sapiens_hsa012000.98153510
55Glucagon signaling pathway_Homo sapiens_hsa049220.96464016
56Arginine biosynthesis_Homo sapiens_hsa002200.94787908
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94231466
58GnRH signaling pathway_Homo sapiens_hsa049120.93488600
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92585368
60Long-term potentiation_Homo sapiens_hsa047200.92538265
61Huntingtons disease_Homo sapiens_hsa050160.91546220
62Type II diabetes mellitus_Homo sapiens_hsa049300.91486992
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90143273
64Peroxisome_Homo sapiens_hsa041460.89065136
65Regulation of autophagy_Homo sapiens_hsa041400.86934030
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85664499
67Fatty acid degradation_Homo sapiens_hsa000710.85216340
68Selenocompound metabolism_Homo sapiens_hsa004500.81148126
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80701703
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76664470
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76272032
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74397928
73Pyruvate metabolism_Homo sapiens_hsa006200.73819490
74Linoleic acid metabolism_Homo sapiens_hsa005910.72545638
75Fatty acid metabolism_Homo sapiens_hsa012120.72380545
76Type I diabetes mellitus_Homo sapiens_hsa049400.71117622
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70649744
78Mineral absorption_Homo sapiens_hsa049780.69972657
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69825410
80Pancreatic secretion_Homo sapiens_hsa049720.66377364
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66153717
82Butanoate metabolism_Homo sapiens_hsa006500.65861993
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.64053342
84Estrogen signaling pathway_Homo sapiens_hsa049150.64012206
85Collecting duct acid secretion_Homo sapiens_hsa049660.63283329
86Insulin signaling pathway_Homo sapiens_hsa049100.62854461
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62762489
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62666934
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61620785
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61448250
91Long-term depression_Homo sapiens_hsa047300.60749678
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.60495274
93Melanogenesis_Homo sapiens_hsa049160.58316654
94Dorso-ventral axis formation_Homo sapiens_hsa043200.57933000
95Arginine and proline metabolism_Homo sapiens_hsa003300.56723222
96Axon guidance_Homo sapiens_hsa043600.56160614
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.56097659
98AMPK signaling pathway_Homo sapiens_hsa041520.55877052
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55502545
100Insulin resistance_Homo sapiens_hsa049310.54012636
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53456811
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52762498
103Tight junction_Homo sapiens_hsa045300.52363183
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51789225
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.51532064
106Ovarian steroidogenesis_Homo sapiens_hsa049130.48139283
107Thyroid hormone synthesis_Homo sapiens_hsa049180.48106656
108Bile secretion_Homo sapiens_hsa049760.47336480
109PPAR signaling pathway_Homo sapiens_hsa033200.47259456
110HIF-1 signaling pathway_Homo sapiens_hsa040660.46738535
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46632455
112Fatty acid biosynthesis_Homo sapiens_hsa000610.44262485
113Fructose and mannose metabolism_Homo sapiens_hsa000510.43943505
114Biosynthesis of amino acids_Homo sapiens_hsa012300.43474266
115Rap1 signaling pathway_Homo sapiens_hsa040150.42839319
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.42423717
117Focal adhesion_Homo sapiens_hsa045100.42169371
118Viral myocarditis_Homo sapiens_hsa054160.41759790
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41221449
120ABC transporters_Homo sapiens_hsa020100.41198786
121MAPK signaling pathway_Homo sapiens_hsa040100.40333126
122Vibrio cholerae infection_Homo sapiens_hsa051100.39832314
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38481712
124Renal cell carcinoma_Homo sapiens_hsa052110.38112388
125Metabolic pathways_Homo sapiens_hsa011000.37839522
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36693192
127Ras signaling pathway_Homo sapiens_hsa040140.36456523
128mTOR signaling pathway_Homo sapiens_hsa041500.36315399
129Vitamin B6 metabolism_Homo sapiens_hsa007500.35757311
130Inositol phosphate metabolism_Homo sapiens_hsa005620.34537557
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32487617
132Galactose metabolism_Homo sapiens_hsa000520.31776750
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29823562
134ECM-receptor interaction_Homo sapiens_hsa045120.29290108

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