KCNA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)7.81589123
2negative regulation of T-helper cell differentiation (GO:0045623)7.81589123
3regulation of T-helper 1 cell differentiation (GO:0045625)7.02808782
4negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)6.75310189
5negative regulation of type 2 immune response (GO:0002829)6.55215107
6positive regulation of gamma-delta T cell activation (GO:0046645)6.55120045
7detection of chemical stimulus involved in sensory perception of smell (GO:0050911)6.36408845
8regulation of T-helper 2 cell differentiation (GO:0045628)6.27216417
9protein K11-linked deubiquitination (GO:0035871)6.20310562
10positive regulation of protein sumoylation (GO:0033235)5.77509420
11tooth mineralization (GO:0034505)5.55024070
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.43264052
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.43264052
14negative regulation of alpha-beta T cell differentiation (GO:0046639)5.40761151
15activation of protein kinase A activity (GO:0034199)5.08685343
16antigen processing and presentation of endogenous antigen (GO:0019883)5.01999425
17positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.97304903
18hepatocyte apoptotic process (GO:0097284)4.94831474
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.89776490
20regulation of gamma-delta T cell differentiation (GO:0045586)4.87057566
21negative T cell selection (GO:0043383)4.82784134
22regulation of gamma-delta T cell activation (GO:0046643)4.75619853
23negative thymic T cell selection (GO:0045060)4.63104877
24seminiferous tubule development (GO:0072520)4.63011232
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.62908514
26negative regulation of cell killing (GO:0031342)4.62908514
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.54472516
28positive thymic T cell selection (GO:0045059)4.48362591
29positive regulation of RNA splicing (GO:0033120)4.35195246
30positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.33725519
31negative regulation of alpha-beta T cell activation (GO:0046636)4.31829148
32regulation of interleukin-12 biosynthetic process (GO:0045075)4.22886925
33modulation by symbiont of host defense response (GO:0052031)4.17526676
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.17526676
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.17526676
36positive regulation by organism of defense response of other organism involved in symbiotic interact4.17526676
37modulation by symbiont of host immune response (GO:0052553)4.17526676
38positive regulation by symbiont of host defense response (GO:0052509)4.17526676
39heterotypic cell-cell adhesion (GO:0034113)4.16653107
40positive T cell selection (GO:0043368)4.16555373
41regulation of B cell receptor signaling pathway (GO:0050855)4.15386712
42mast cell activation (GO:0045576)4.12405649
43positive regulation of B cell differentiation (GO:0045579)4.10329380
44positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.05944756
45positive regulation of T-helper 1 type immune response (GO:0002827)4.05163041
46positive regulation of granulocyte differentiation (GO:0030854)4.04137620
47leukocyte aggregation (GO:0070486)4.01307162
48cAMP biosynthetic process (GO:0006171)4.00568116
49T cell selection (GO:0045058)3.99926101
50regulation of B cell differentiation (GO:0045577)3.98271881
51positive regulation of T-helper cell differentiation (GO:0045624)3.97276150
52detection of chemical stimulus involved in sensory perception (GO:0050907)3.95053464
53interferon-gamma production (GO:0032609)3.94276117
54regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.94092907
55thymic T cell selection (GO:0045061)3.91598630
56response to interleukin-15 (GO:0070672)3.87609592
57T cell migration (GO:0072678)3.82334571
58positive regulation of alpha-beta T cell differentiation (GO:0046638)3.79717170
59tolerance induction (GO:0002507)3.76426653
60regulation of T-helper 1 type immune response (GO:0002825)3.76053069
61positive regulation of interleukin-2 production (GO:0032743)3.73465159
62regulation of interleukin-2 biosynthetic process (GO:0045076)3.69352817
63regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.67593331
64synaptic transmission, dopaminergic (GO:0001963)3.66410676
65positive regulation of isotype switching (GO:0045830)3.62761117
66regulation of type 2 immune response (GO:0002828)3.60649962
67regulation of alpha-beta T cell proliferation (GO:0046640)3.59995616
68regulation of isotype switching to IgG isotypes (GO:0048302)3.56504294
69regulation of T-helper cell differentiation (GO:0045622)3.55179061
70NIK/NF-kappaB signaling (GO:0038061)3.55107647
71regulation of alpha-beta T cell differentiation (GO:0046637)3.52656816
72positive regulation of alpha-beta T cell activation (GO:0046635)3.51609535
73B cell receptor signaling pathway (GO:0050853)3.44463163
74regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.44235802
75myeloid dendritic cell activation (GO:0001773)3.43681591
76immunoglobulin mediated immune response (GO:0016064)3.40900025
77positive regulation of alpha-beta T cell proliferation (GO:0046641)3.40588008
78defense response to protozoan (GO:0042832)3.40434063
79T cell homeostasis (GO:0043029)3.39922511
80regulation of alpha-beta T cell activation (GO:0046634)3.36751456
81regulation of protein sumoylation (GO:0033233)3.35087605
82cellular response to interleukin-15 (GO:0071350)3.30507636
83T cell receptor signaling pathway (GO:0050852)3.30471026
84positive regulation of B cell mediated immunity (GO:0002714)3.29048357
85positive regulation of immunoglobulin mediated immune response (GO:0002891)3.29048357
86myeloid dendritic cell differentiation (GO:0043011)3.26843103
87antigen receptor-mediated signaling pathway (GO:0050851)3.26543047
88regulation of T cell tolerance induction (GO:0002664)3.26050903
89response to protozoan (GO:0001562)3.24740561
90negative regulation of interleukin-12 production (GO:0032695)3.22785945
91mast cell activation involved in immune response (GO:0002279)3.22559106
92mast cell degranulation (GO:0043303)3.22559106
93positive regulation of humoral immune response (GO:0002922)3.21104239
94neutrophil activation involved in immune response (GO:0002283)3.20079174
95regulation of T cell receptor signaling pathway (GO:0050856)3.18558850
96regulation of regulatory T cell differentiation (GO:0045589)3.18125993
97positive regulation of T cell differentiation (GO:0045582)3.13873403
98positive regulation of DNA recombination (GO:0045911)3.13355118
99T cell costimulation (GO:0031295)3.12439835
100neural tube formation (GO:0001841)3.09946687
101lymphocyte costimulation (GO:0031294)3.07031811
102positive regulation of mitochondrial fission (GO:0090141)3.06964640
103negative regulation of T cell mediated immunity (GO:0002710)3.05544971
104JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.03926846
105regulation of platelet aggregation (GO:0090330)3.03202519
106regulation of isotype switching (GO:0045191)3.03141561
107interferon-gamma-mediated signaling pathway (GO:0060333)3.01968694
108response to muramyl dipeptide (GO:0032495)3.01178814
109myeloid cell activation involved in immune response (GO:0002275)3.01073420
110natural killer cell differentiation (GO:0001779)3.00945370
111detection of chemical stimulus (GO:0009593)2.99963271
112regulation of B cell mediated immunity (GO:0002712)2.96436665
113regulation of cAMP-mediated signaling (GO:0043949)2.95314526
114lymphocyte homeostasis (GO:0002260)2.94959992
115alpha-beta T cell differentiation (GO:0046632)2.94489038
116positive regulation of lymphocyte differentiation (GO:0045621)2.93208504
117enteric nervous system development (GO:0048484)2.92787204
118regulation of interleukin-2 production (GO:0032663)2.91647925
119regulation of immunoglobulin mediated immune response (GO:0002889)2.91132054
120leukocyte cell-cell adhesion (GO:0007159)2.90598671
121Arp2/3 complex-mediated actin nucleation (GO:0034314)2.89049697
122negative regulation of actin filament bundle assembly (GO:0032232)2.88639862
123cellular extravasation (GO:0045123)2.88023513
124alpha-beta T cell activation (GO:0046631)2.86755638
125positive regulation of natural killer cell differentiation (GO:0032825)2.84828722
126cellular response to zinc ion (GO:0071294)2.83412097
127positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.83368921
128natural killer cell activation (GO:0030101)2.83293905
129response to peptidoglycan (GO:0032494)2.82041900
130response to type I interferon (GO:0034340)2.81685646
131T cell proliferation (GO:0042098)2.81594368
132positive regulation of tolerance induction (GO:0002645)2.80903241
133cellular response to type I interferon (GO:0071357)2.79703493
134type I interferon signaling pathway (GO:0060337)2.79703493
135positive regulation of interferon-alpha production (GO:0032727)2.78875337
136positive regulation of macrophage differentiation (GO:0045651)2.78684543
137regulation of interferon-beta biosynthetic process (GO:0045357)2.78439156
138activated T cell proliferation (GO:0050798)2.77443043
139regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.77335384
140regulation of response to interferon-gamma (GO:0060330)2.77280653
141positive regulation of B cell activation (GO:0050871)2.76752992
142positive regulation of cytokine biosynthetic process (GO:0042108)2.76477111
143B cell mediated immunity (GO:0019724)2.75813942
144negative regulation of T cell differentiation (GO:0045581)2.75792864
145neutrophil activation (GO:0042119)2.75569487
146granulocyte activation (GO:0036230)2.75560227
147endothelial cell differentiation (GO:0045446)2.74316447
148CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.73448607
149regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.72586486
150negative regulation of lymphocyte mediated immunity (GO:0002707)2.71740740
151regulation of tolerance induction (GO:0002643)2.70549988
152regulation of granulocyte differentiation (GO:0030852)2.70109442
153regulation of chronic inflammatory response (GO:0002676)2.68869073
154positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.66111120

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.95301465
2E2F7_22180533_ChIP-Seq_HELA_Human5.89567952
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.69642885
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.00219070
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.89327251
6EGR1_19374776_ChIP-ChIP_THP-1_Human4.19061749
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.06958822
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.88269497
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.83564403
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.56162907
11MYC_22102868_ChIP-Seq_BL_Human3.44614443
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.23317448
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.15184186
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.04388599
15* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.99055852
16* MYB_26560356_Chip-Seq_TH2_Human2.86302768
17RUNX_20019798_ChIP-Seq_JUKART_Human2.81419029
18IGF1R_20145208_ChIP-Seq_DFB_Human2.78994100
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71730217
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.70793881
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69661639
22VDR_21846776_ChIP-Seq_THP-1_Human2.67785216
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.65926687
24SCL_19346495_ChIP-Seq_HPC-7_Human2.61910945
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58940434
26* MAF_26560356_Chip-Seq_TH1_Human2.55834287
27AR_21572438_ChIP-Seq_LNCaP_Human2.55825998
28* MYB_26560356_Chip-Seq_TH1_Human2.41290092
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.39099458
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26050775
31* UTX_26944678_Chip-Seq_JUKART_Human2.20220633
32VDR_24763502_ChIP-Seq_THP-1_Human2.19321476
33GATA1_19941826_ChIP-Seq_K562_Human2.17782838
34SPI1_23547873_ChIP-Seq_NB4_Human2.17624300
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17394175
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.14387122
37TCF7_22412390_ChIP-Seq_EML_Mouse2.06268552
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.95033391
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.91703417
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87885166
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.84456648
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82427925
43* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.79575244
44GATA3_27048872_Chip-Seq_THYMUS_Human1.76371765
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73948951
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73337723
47SPI1_23127762_ChIP-Seq_K562_Human1.68482122
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67642313
49* MAF_26560356_Chip-Seq_TH2_Human1.67213644
50VDR_22108803_ChIP-Seq_LS180_Human1.64837008
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60338020
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57903318
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.56714604
54* KDM2B_26808549_Chip-Seq_DND41_Human1.54835746
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53374162
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52996705
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52525005
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42275799
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38878796
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38302071
61GATA2_19941826_ChIP-Seq_K562_Human1.35212482
62PU_27001747_Chip-Seq_BMDM_Mouse1.34359881
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.33784415
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32190810
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30780427
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30258462
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29866990
68FOXM1_23109430_ChIP-Seq_U2OS_Human1.27673959
69* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.27521728
70CIITA_25753668_ChIP-Seq_RAJI_Human1.27272251
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26545902
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25001112
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22108333
74TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.18616579
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18321061
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14296967
77DROSHA_22980978_ChIP-Seq_HELA_Human1.13694740
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12792804
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12659110
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.11970268
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11945969
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11559393
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11182583
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11182583
85VDR_23849224_ChIP-Seq_CD4+_Human1.10963614
86YY1_22570637_ChIP-Seq_MALME-3M_Human1.09006970
87GATA3_26560356_Chip-Seq_TH2_Human1.08884228
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08881148
89* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08067389
90GATA1_19941827_ChIP-Seq_MEL86_Mouse1.05658476
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05154258
92CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00487957
93PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99414680
94VDR_24787735_ChIP-Seq_THP-1_Human0.99329871
95GATA1_19941827_ChIP-Seq_MEL_Mouse0.98724513
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98530433
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96901641
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.95597767
99ELK3_25401928_ChIP-Seq_HUVEC_Human0.95270846
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94220425
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94197879
102FOXP3_21729870_ChIP-Seq_TREG_Human0.93906707
103SMAD_19615063_ChIP-ChIP_OVARY_Human0.93617287
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91286343
105* KDM2B_26808549_Chip-Seq_JURKAT_Human0.90340369
106GATA1_22025678_ChIP-Seq_K562_Human0.89776979
107* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89289756
108TP53_16413492_ChIP-PET_HCT116_Human0.89041246
109* PRDM14_20953172_ChIP-Seq_ESCs_Human0.88876525
110KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.88837173
111* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87796444
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87311019
113EGR1_19032775_ChIP-ChIP_M12_Human0.86781548
114FLI1_27457419_Chip-Seq_LIVER_Mouse0.85946114
115TFEB_21752829_ChIP-Seq_HELA_Human0.85815529
116GATA3_26560356_Chip-Seq_TH1_Human0.83941965
117FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80801796
118EZH2_27294783_Chip-Seq_NPCs_Mouse0.80510309
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80279869
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79953692
121SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79142590
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.78725752
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78323503
124CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78265411
125CTCF_27219007_Chip-Seq_ERYTHROID_Human0.77874549
126ETS1_22383799_ChIP-Seq_G1ME_Mouse0.76161677
127FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.75702590
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.75029831
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.74489193
130PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74172737
131MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.72938743
132TP63_19390658_ChIP-ChIP_HaCaT_Human0.69323917
133KDM5A_27292631_Chip-Seq_BREAST_Human0.68682195
134FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.66379698
135* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65172381

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005084_abnormal_gallbladder_morpholo5.17901117
2MP0001835_abnormal_antigen_presentation4.25792956
3MP0005671_abnormal_response_to3.55414115
4MP0003763_abnormal_thymus_physiology3.48818534
5MP0003303_peritoneal_inflammation3.38385434
6MP0003436_decreased_susceptibility_to3.37101597
7MP0000685_abnormal_immune_system3.27788124
8MP0005000_abnormal_immune_tolerance3.17986839
9MP0001800_abnormal_humoral_immune3.16559712
10MP0005387_immune_system_phenotype3.16167823
11MP0001790_abnormal_immune_system3.16167823
12MP0009785_altered_susceptibility_to2.95183311
13MP0002396_abnormal_hematopoietic_system2.82252950
14MP0002452_abnormal_antigen_presenting2.80054054
15MP0002723_abnormal_immune_serum2.78253195
16MP0002420_abnormal_adaptive_immunity2.72874539
17MP0001819_abnormal_immune_cell2.70251128
18MP0005025_abnormal_response_to2.69997612
19MP0002148_abnormal_hypersensitivity_rea2.59649596
20MP0002398_abnormal_bone_marrow2.58656741
21MP0002166_altered_tumor_susceptibility2.54548822
22MP0002419_abnormal_innate_immunity2.48467799
23MP0002006_tumorigenesis2.31984028
24MP0000716_abnormal_immune_system2.30415301
25MP0002405_respiratory_system_inflammati2.29468173
26MP0003724_increased_susceptibility_to2.23574305
27MP0004510_myositis2.09530822
28MP0000689_abnormal_spleen_morphology2.06345319
29MP0006082_CNS_inflammation2.04118011
30MP0009333_abnormal_splenocyte_physiolog2.03525401
31MP0002722_abnormal_immune_system2.01369286
32MP0000703_abnormal_thymus_morphology1.99684399
33MP0001545_abnormal_hematopoietic_system1.98496913
34MP0005397_hematopoietic_system_phenotyp1.98496913
35MP0005464_abnormal_platelet_physiology1.96535737
36MP0003300_gastrointestinal_ulcer1.95521744
37MP0002429_abnormal_blood_cell1.91199140
38MP0001853_heart_inflammation1.84820342
39MP0010155_abnormal_intestine_physiology1.83662505
40MP0004264_abnormal_extraembryonic_tissu1.81742889
41MP0003866_abnormal_defecation1.79152068
42MP0004808_abnormal_hematopoietic_stem1.78951682
43MP0001873_stomach_inflammation1.75612963
44MP0000465_gastrointestinal_hemorrhage1.74346419
45MP0009278_abnormal_bone_marrow1.71930035
46MP0004947_skin_inflammation1.70466207
47MP0001845_abnormal_inflammatory_respons1.67800278
48MP0008004_abnormal_stomach_pH1.61300452
49MP0000569_abnormal_digit_pigmentation1.50761066
50MP0003252_abnormal_bile_duct1.46430034
51MP0002009_preneoplasia1.43015280
52MP0005174_abnormal_tail_pigmentation1.42953124
53MP0001533_abnormal_skeleton_physiology1.42024515
54MP0003172_abnormal_lysosome_physiology1.38293342
55MP0000490_abnormal_crypts_of1.32477887
56MP0002928_abnormal_bile_duct1.32136718
57MP0003329_amyloid_beta_deposits1.31470879
58MP0008057_abnormal_DNA_replication1.28120780
59MP0005310_abnormal_salivary_gland1.26351322
60MP0002933_joint_inflammation1.25303515
61MP0000858_altered_metastatic_potential1.22039030
62MP0005076_abnormal_cell_differentiation1.21953583
63MP0008469_abnormal_protein_level1.18659195
64MP0010094_abnormal_chromosome_stability1.09083571
65MP0006054_spinal_hemorrhage1.05857786
66MP0003448_altered_tumor_morphology1.03692722
67MP0002019_abnormal_tumor_incidence1.00546221
68MP0001851_eye_inflammation0.98987693
69MP0010307_abnormal_tumor_latency0.98926941
70MP0005075_abnormal_melanosome_morpholog0.97547732
71MP0009764_decreased_sensitivity_to0.96494694
72MP0002998_abnormal_bone_remodeling0.94536344
73MP0004883_abnormal_blood_vessel0.88840361
74MP0001270_distended_abdomen0.83354936
75MP0002132_abnormal_respiratory_system0.83276567
76MP0005164_abnormal_response_to0.82382947
77MP0003077_abnormal_cell_cycle0.81412537
78MP0000015_abnormal_ear_pigmentation0.81007876
79MP0008569_lethality_at_weaning0.80710347
80MP0005058_abnormal_lysosome_morphology0.80498404
81MP0002277_abnormal_respiratory_mucosa0.75995511
82MP0010352_gastrointestinal_tract_polyps0.75412018
83MP0008995_early_reproductive_senescence0.74736254
84MP0001663_abnormal_digestive_system0.72031455
85MP0002095_abnormal_skin_pigmentation0.71381447
86MP0005379_endocrine/exocrine_gland_phen0.69689698
87MP0003075_altered_response_to0.68995289
88MP0000604_amyloidosis0.68740386
89MP0003111_abnormal_nucleus_morphology0.68164537
90MP0005166_decreased_susceptibility_to0.68145596
91MP0003191_abnormal_cellular_cholesterol0.66683489
92MP0005451_abnormal_body_composition0.66104932
93MP0000343_altered_response_to0.65371217
94MP0003638_abnormal_response/metabolism_0.63273502
95MP0001501_abnormal_sleep_pattern0.62424798
96* MP0008961_abnormal_basal_metabolism0.61290114
97MP0003656_abnormal_erythrocyte_physiolo0.60388618
98MP0008007_abnormal_cellular_replicative0.59913064
99MP0005165_increased_susceptibility_to0.59858602
100MP0001986_abnormal_taste_sensitivity0.59645255
101MP0003787_abnormal_imprinting0.59313508
102MP0000313_abnormal_cell_death0.58399681
103MP0000371_diluted_coat_color0.58283357
104MP0004381_abnormal_hair_follicle0.57679946
105MP0002136_abnormal_kidney_physiology0.57420149
106MP0008260_abnormal_autophagy0.57400692
107MP0009763_increased_sensitivity_to0.56515581
108MP0001915_intracranial_hemorrhage0.56491032
109MP0000609_abnormal_liver_physiology0.55770158
110MP0008058_abnormal_DNA_repair0.55428591
111MP0004484_altered_response_of0.54980410
112MP0009765_abnormal_xenobiotic_induced0.54949097
113MP0003943_abnormal_hepatobiliary_system0.54736894
114MP0008873_increased_physiological_sensi0.54501310
115* MP0004130_abnormal_muscle_cell0.54269645
116MP0000470_abnormal_stomach_morphology0.54113820
117MP0003045_fibrosis0.54083665
118MP0002138_abnormal_hepatobiliary_system0.53861995
119MP0005645_abnormal_hypothalamus_physiol0.52660422
120MP0005390_skeleton_phenotype0.52031194
121MP0001348_abnormal_lacrimal_gland0.51926694
122MP0003795_abnormal_bone_structure0.48710047
123MP0003828_pulmonary_edema0.45703410
124MP0000350_abnormal_cell_proliferation0.45526002
125MP0002736_abnormal_nociception_after0.44319672
126MP0002083_premature_death0.43861518
127MP0002693_abnormal_pancreas_physiology0.40488870
128MP0000249_abnormal_blood_vessel0.40283735
129MP0009840_abnormal_foam_cell0.36091342
130MP0000367_abnormal_coat/_hair0.35766575
131MP0003693_abnormal_embryo_hatching0.35280911

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.01240475
2Eczematoid dermatitis (HP:0000976)4.72348056
3T lymphocytopenia (HP:0005403)4.70038582
4Abnormality of T cell number (HP:0011839)4.69109297
5Recurrent viral infections (HP:0004429)4.61685286
6Recurrent fungal infections (HP:0002841)4.60809346
7Panhypogammaglobulinemia (HP:0003139)4.56910874
8Recurrent abscess formation (HP:0002722)4.55480750
9Amelogenesis imperfecta (HP:0000705)4.48986169
10Overgrowth (HP:0001548)4.32876863
11IgM deficiency (HP:0002850)4.28695448
12Chronic otitis media (HP:0000389)4.27627706
13Myositis (HP:0100614)4.18333120
14Recurrent bronchitis (HP:0002837)4.17400003
15Recurrent bacterial skin infections (HP:0005406)4.14186693
16Abnormality of calcium-phosphate metabolism (HP:0100530)3.87529980
17Stomatitis (HP:0010280)3.85490877
18Abnormality of T cells (HP:0002843)3.84400845
19B lymphocytopenia (HP:0010976)3.77378964
20Abnormality of B cell number (HP:0010975)3.77378964
21Mediastinal lymphadenopathy (HP:0100721)3.76126582
22Abnormality of the fingertips (HP:0001211)3.72948614
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.69913405
24Recurrent cutaneous fungal infections (HP:0011370)3.52490825
25Chronic mucocutaneous candidiasis (HP:0002728)3.52490825
26Autoimmune thrombocytopenia (HP:0001973)3.48206121
27Severe combined immunodeficiency (HP:0004430)3.47353680
28Abnormality of dental color (HP:0011073)3.45196648
29Retrobulbar optic neuritis (HP:0100654)3.39011739
30Optic neuritis (HP:0100653)3.39011739
31Recurrent gram-negative bacterial infections (HP:0005420)3.36335163
32Meningitis (HP:0001287)3.34519322
33Nasal polyposis (HP:0100582)3.33446437
34Thyroiditis (HP:0100646)3.29733795
35Combined immunodeficiency (HP:0005387)3.26606279
36Vasculitis (HP:0002633)3.18411037
37Orchitis (HP:0100796)3.16412475
38IgG deficiency (HP:0004315)3.16221072
39Recurrent skin infections (HP:0001581)3.13879241
40Thrombocytosis (HP:0001894)3.08476149
41Abnormal platelet volume (HP:0011876)3.08047853
42Eosinophilia (HP:0001880)3.05963080
43Polyuria (HP:0000103)2.98808828
44Cellulitis (HP:0100658)2.95659350
45Abnormality of T cell physiology (HP:0011840)2.92710585
46Menorrhagia (HP:0000132)2.91734335
47Agammaglobulinemia (HP:0004432)2.89419526
48Pustule (HP:0200039)2.88521946
49Hypoplasia of the thymus (HP:0000778)2.86078670
50Abnormality of renal resorption (HP:0011038)2.85641732
51Leukocytosis (HP:0001974)2.83107878
52Obstructive lung disease (HP:0006536)2.83075411
53Chronic obstructive pulmonary disease (HP:0006510)2.83075411
54Purpura (HP:0000979)2.82088752
55Increased mean platelet volume (HP:0011877)2.82048685
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.77050099
57Abnormality of the nasal mucosa (HP:0000433)2.75057116
58Chronic sinusitis (HP:0011109)2.74946420
59Lymphopenia (HP:0001888)2.74464054
60IgA deficiency (HP:0002720)2.72034256
61Abnormality of eosinophils (HP:0001879)2.66402194
62Increased IgM level (HP:0003496)2.65493859
63Inflammation of the large intestine (HP:0002037)2.59319039
64Granulocytopenia (HP:0001913)2.58392527
65Spontaneous hematomas (HP:0007420)2.57895982
66Gingivitis (HP:0000230)2.57346064
67Volvulus (HP:0002580)2.57178338
68Papilledema (HP:0001085)2.53999984
69Gastrointestinal inflammation (HP:0004386)2.51401569
70Abnormality of macrophages (HP:0004311)2.50676073
71Pulmonary infiltrates (HP:0002113)2.50381414
72Chronic diarrhea (HP:0002028)2.48394583
73Petechiae (HP:0000967)2.47449330
74Abnormal urine output (HP:0012590)2.45348251
75Chest pain (HP:0100749)2.44771138
76Lymphoma (HP:0002665)2.44441039
77Arterial thrombosis (HP:0004420)2.41015640
78Periodontitis (HP:0000704)2.38459640
79Hemoptysis (HP:0002105)2.36260770
80Gastrointestinal stroma tumor (HP:0100723)2.33673717
81Gastrointestinal infarctions (HP:0005244)2.28408386
82Encephalitis (HP:0002383)2.28363847
83Prolonged bleeding time (HP:0003010)2.26534678
84Hepatitis (HP:0012115)2.25256079
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.24177337
86Hypergammaglobulinemia (HP:0010702)2.23915544
87Osteomalacia (HP:0002749)2.22261492
88Papilloma (HP:0012740)2.20646648
89Verrucae (HP:0200043)2.20646648
90Keratoconjunctivitis sicca (HP:0001097)2.16276930
91Autoimmune hemolytic anemia (HP:0001890)2.14052455
92Osteomyelitis (HP:0002754)2.11182427
93Abnormality of transition element cation homeostasis (HP:0011030)2.10593451
94Colitis (HP:0002583)2.10134953
95Bronchitis (HP:0012387)2.09761310
96Increased density of long bones (HP:0006392)2.09498212
97Gingival bleeding (HP:0000225)2.08301854
98Recurrent sinusitis (HP:0011108)2.06387397
99Basal ganglia calcification (HP:0002135)2.05678520
100Epistaxis (HP:0000421)2.05639334
101Abnormality of the prostate (HP:0008775)2.02772798
102Abnormality of renal excretion (HP:0011036)2.02620289
103Interstitial pulmonary disease (HP:0006530)2.01673809
104Abnormality of the dental pulp (HP:0006479)2.01469091
105Leukopenia (HP:0001882)2.01293659
106Acute myeloid leukemia (HP:0004808)2.01059215
107Joint swelling (HP:0001386)2.00711934
108Sepsis (HP:0100806)1.98581266
109Clubbing of toes (HP:0100760)1.97776026
110Polyneuropathy (HP:0001271)1.97443101
111Toxemia of pregnancy (HP:0100603)1.95703613
112Viral hepatitis (HP:0006562)1.94591385
113Increased IgE level (HP:0003212)1.93599100
114Pulmonary embolism (HP:0002204)1.93107712
115Recurrent otitis media (HP:0000403)1.92418521
116Keratoconjunctivitis (HP:0001096)1.91976588
117Arthralgia (HP:0002829)1.90610234
118Hyperlipoproteinemia (HP:0010980)1.90095193
119Abnormality of DNA repair (HP:0003254)1.89177440
120Gangrene (HP:0100758)1.88932705
121Myelodysplasia (HP:0002863)1.87342577
122Chromsome breakage (HP:0040012)1.83873088
123Emphysema (HP:0002097)1.83342771
124Cheilitis (HP:0100825)1.83039019

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.26320795
2TXK4.22097649
3JAK33.13563853
4ZAP702.79397141
5MAP3K142.77625097
6TBK12.32128371
7BLK2.17679632
8IKBKE2.17177232
9BTK2.15311399
10TYK22.14036103
11KIT2.12442168
12PRPF4B2.11272449
13SYK1.99964338
14IRAK41.97957048
15ITK1.91310337
16RIPK41.89816659
17MAP3K101.86751481
18STK101.77065905
19GRK61.76615306
20IKBKB1.74765947
21CAMKK21.74576100
22TEC1.74041917
23BMPR21.73377425
24EEF2K1.64566301
25SIK21.56563086
26JAK11.53018456
27PIM21.52728074
28CHUK1.52040537
29LCK1.50272108
30HCK1.45377248
31CSF1R1.44087536
32CSK1.42605209
33SIK31.37328255
34STK31.36665661
35FES1.36014121
36CLK11.25129869
37PIM11.24798310
38CDC42BPA1.24074366
39FGFR31.14534692
40FGFR41.12086862
41MAP3K111.11974351
42LYN1.10213858
43TSSK61.09753349
44JAK21.05708339
45NLK1.04833926
46EPHA31.01604692
47PIK3CG1.00744786
48CDK61.00312411
49MAP3K130.98183464
50TNK20.93959700
51ERN10.87815612
52MARK30.86846237
53GRK70.82681786
54MAP3K120.82501017
55CDK120.80726319
56PRKCQ0.80709543
57LRRK20.78687070
58NME20.77856890
59IRAK30.76445892
60NEK20.75889533
61FGR0.75079060
62MAP2K30.71051669
63TAOK30.70233681
64PTK60.67981397
65PRKCH0.67975561
66MAP3K10.66861596
67MAP3K70.65081372
68RPS6KA60.64410604
69TNIK0.63899884
70TAOK10.63377014
71MAPK40.63034909
72TGFBR20.62716834
73DYRK1B0.62305398
74MAPK70.61910581
75IRAK10.61258233
76MAPK120.60453033
77TESK20.59313203
78ALK0.58637791
79CDK40.58265361
80RPS6KA40.55855863
81SCYL20.53907164
82ATR0.53536845
83IRAK20.50842942
84RPS6KC10.49641805
85RPS6KL10.49641805
86MATK0.49523719
87NEK10.49277494
88STK40.48922477
89DAPK10.48329474
90MAPK110.47656783
91HIPK20.47455101
92PKN20.45740144
93BRD40.45505622
94EPHB10.45252275
95MAP3K50.44499469
96TYRO30.43330098
97ADRBK20.43086350
98GRK50.42995110
99ABL10.42783452
100TRIB30.42393856
101SGK20.41282685
102MAP3K30.41174295
103MARK20.40577420
104YES10.40448285
105RIPK10.38885368
106EGFR0.38721355
107CAMK40.38620143
108TAOK20.37587752
109FLT30.37509109
110RET0.37369675
111PDK10.36648997
112SRPK10.36421145
113PASK0.35178816
114FYN0.34109952
115CSNK1A1L0.33576020
116PAK40.32742156
117RPS6KA10.32610749
118UHMK10.31349776
119CDC70.30621704
120BMX0.30532323
121MST40.29048080
122MAPK30.27126669
123PTK2B0.26998112
124ACVR1B0.26492243
125RPS6KA20.26055874
126KDR0.24973692
127MAP4K20.24833363
128PRKD20.24673162
129RPS6KA50.24374790
130PDGFRB0.23836349
131CAMKK10.23691100
132MAPK130.22154377
133PRKACG0.21221951
134PRKCB0.20666361

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.67819437
2Allograft rejection_Homo sapiens_hsa053302.70990102
3Olfactory transduction_Homo sapiens_hsa047402.68060127
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.59657796
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.53633374
6Leishmaniasis_Homo sapiens_hsa051402.52361597
7Graft-versus-host disease_Homo sapiens_hsa053322.48959736
8T cell receptor signaling pathway_Homo sapiens_hsa046602.38929862
9Measles_Homo sapiens_hsa051622.35285975
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.30551744
11B cell receptor signaling pathway_Homo sapiens_hsa046622.27230704
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.20925936
13Osteoclast differentiation_Homo sapiens_hsa043802.09276175
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.95976545
15Type I diabetes mellitus_Homo sapiens_hsa049401.95431290
16Antigen processing and presentation_Homo sapiens_hsa046121.94315453
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89110977
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.85359186
19Hematopoietic cell lineage_Homo sapiens_hsa046401.85259690
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82731062
21Asthma_Homo sapiens_hsa053101.77324316
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.67964343
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.64144195
24Legionellosis_Homo sapiens_hsa051341.62006834
25Herpes simplex infection_Homo sapiens_hsa051681.60294053
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.59349599
27DNA replication_Homo sapiens_hsa030301.56547496
28Tuberculosis_Homo sapiens_hsa051521.55771947
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.49796949
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.45807710
31Influenza A_Homo sapiens_hsa051641.44402089
32Acute myeloid leukemia_Homo sapiens_hsa052211.44275391
33Ovarian steroidogenesis_Homo sapiens_hsa049131.44056751
34Toxoplasmosis_Homo sapiens_hsa051451.43446930
35TNF signaling pathway_Homo sapiens_hsa046681.40040546
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40018107
37Autoimmune thyroid disease_Homo sapiens_hsa053201.39130376
38Hepatitis B_Homo sapiens_hsa051611.35749877
39Chemokine signaling pathway_Homo sapiens_hsa040621.32703598
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32670659
41Shigellosis_Homo sapiens_hsa051311.27646472
42Pertussis_Homo sapiens_hsa051331.26347037
43Viral myocarditis_Homo sapiens_hsa054161.25555356
44Chronic myeloid leukemia_Homo sapiens_hsa052201.24850903
45Malaria_Homo sapiens_hsa051441.24139857
46Collecting duct acid secretion_Homo sapiens_hsa049661.20378401
47Base excision repair_Homo sapiens_hsa034101.19420014
48Linoleic acid metabolism_Homo sapiens_hsa005911.17794183
49Apoptosis_Homo sapiens_hsa042101.15711137
50Morphine addiction_Homo sapiens_hsa050321.08329084
51Rheumatoid arthritis_Homo sapiens_hsa053231.07423909
52Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06005085
53Non-homologous end-joining_Homo sapiens_hsa034501.04940294
54Salmonella infection_Homo sapiens_hsa051321.03541875
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01573323
56GnRH signaling pathway_Homo sapiens_hsa049120.99408025
57Pancreatic secretion_Homo sapiens_hsa049720.97322210
58Epstein-Barr virus infection_Homo sapiens_hsa051690.96128590
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.95414078
60Gastric acid secretion_Homo sapiens_hsa049710.94082297
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93940185
62Viral carcinogenesis_Homo sapiens_hsa052030.93168707
63Circadian entrainment_Homo sapiens_hsa047130.92767373
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.92276165
65Salivary secretion_Homo sapiens_hsa049700.91927112
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91129810
67Sulfur relay system_Homo sapiens_hsa041220.88811143
68HTLV-I infection_Homo sapiens_hsa051660.88552280
69Pancreatic cancer_Homo sapiens_hsa052120.86604628
70Staphylococcus aureus infection_Homo sapiens_hsa051500.86604442
71Mismatch repair_Homo sapiens_hsa034300.85927320
72Dorso-ventral axis formation_Homo sapiens_hsa043200.85602612
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85430779
74Sulfur metabolism_Homo sapiens_hsa009200.84599047
75Colorectal cancer_Homo sapiens_hsa052100.84506823
76African trypanosomiasis_Homo sapiens_hsa051430.84346048
77Cholinergic synapse_Homo sapiens_hsa047250.82229013
78GABAergic synapse_Homo sapiens_hsa047270.80064979
79Prolactin signaling pathway_Homo sapiens_hsa049170.79670242
80Non-small cell lung cancer_Homo sapiens_hsa052230.77263516
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.77201206
82Oxytocin signaling pathway_Homo sapiens_hsa049210.77006885
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76961141
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.76611406
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75745064
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75188693
87Gap junction_Homo sapiens_hsa045400.74947979
88Platelet activation_Homo sapiens_hsa046110.73531812
89Circadian rhythm_Homo sapiens_hsa047100.72558794
90Vibrio cholerae infection_Homo sapiens_hsa051100.72418582
91Hepatitis C_Homo sapiens_hsa051600.71940566
92Amphetamine addiction_Homo sapiens_hsa050310.70546918
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69381888
94Cocaine addiction_Homo sapiens_hsa050300.69141502
95Glutamatergic synapse_Homo sapiens_hsa047240.68919059
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65085753
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64981613
98Thyroid cancer_Homo sapiens_hsa052160.63386202
99Spliceosome_Homo sapiens_hsa030400.62487940
100Taste transduction_Homo sapiens_hsa047420.61138627
101Calcium signaling pathway_Homo sapiens_hsa040200.61080578
102Estrogen signaling pathway_Homo sapiens_hsa049150.61001446
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60723972
104Ether lipid metabolism_Homo sapiens_hsa005650.58803398
105Arachidonic acid metabolism_Homo sapiens_hsa005900.58795780
106Thyroid hormone synthesis_Homo sapiens_hsa049180.57884038
107Synaptic vesicle cycle_Homo sapiens_hsa047210.56770056
108Fanconi anemia pathway_Homo sapiens_hsa034600.56457235
109Homologous recombination_Homo sapiens_hsa034400.53847024
110Bile secretion_Homo sapiens_hsa049760.49102283
111Endometrial cancer_Homo sapiens_hsa052130.48787091
112Small cell lung cancer_Homo sapiens_hsa052220.47972274
113Phagosome_Homo sapiens_hsa041450.46648270
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44925298
115MicroRNAs in cancer_Homo sapiens_hsa052060.44283553
116MAPK signaling pathway_Homo sapiens_hsa040100.44188866
117VEGF signaling pathway_Homo sapiens_hsa043700.43409257
118Systemic lupus erythematosus_Homo sapiens_hsa053220.42926800
119One carbon pool by folate_Homo sapiens_hsa006700.42165041
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40088310
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.39853260
122Cell cycle_Homo sapiens_hsa041100.37913829
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.37790276
124p53 signaling pathway_Homo sapiens_hsa041150.37580686
125Notch signaling pathway_Homo sapiens_hsa043300.37108234
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35642883
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35457428
128FoxO signaling pathway_Homo sapiens_hsa040680.34266060
129Type II diabetes mellitus_Homo sapiens_hsa049300.31728202
130Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30916456
131Prostate cancer_Homo sapiens_hsa052150.30378758
132Lysosome_Homo sapiens_hsa041420.30201709
133mTOR signaling pathway_Homo sapiens_hsa041500.29936930
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29618359
135Glioma_Homo sapiens_hsa052140.29258956
136Endocytosis_Homo sapiens_hsa041440.28863432
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28768146
138HIF-1 signaling pathway_Homo sapiens_hsa040660.28255775
139RNA degradation_Homo sapiens_hsa030180.27350498
140Nucleotide excision repair_Homo sapiens_hsa034200.27133272

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