KBTBD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)6.67455251
2mitotic chromosome condensation (GO:0007076)6.02483205
3metaphase plate congression (GO:0051310)5.68630009
4regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.45352282
5piRNA metabolic process (GO:0034587)5.43223396
6attachment of spindle microtubules to kinetochore (GO:0008608)5.22669670
7protein localization to kinetochore (GO:0034501)5.17770624
8establishment of chromosome localization (GO:0051303)5.16072281
9mitotic sister chromatid segregation (GO:0000070)5.09437509
10histone H2A monoubiquitination (GO:0035518)4.99639854
11protein localization to chromosome, centromeric region (GO:0071459)4.92507056
12negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.91665082
13meiotic chromosome segregation (GO:0045132)4.91524901
14female gamete generation (GO:0007292)4.91344799
15regulation of meiosis I (GO:0060631)4.89026365
16monoubiquitinated protein deubiquitination (GO:0035520)4.74537726
17regulation of sister chromatid cohesion (GO:0007063)4.69179400
18regulation of spindle organization (GO:0090224)4.60076240
19meiotic cell cycle (GO:0051321)4.58746863
20DNA replication checkpoint (GO:0000076)4.44545682
21positive regulation of chromosome segregation (GO:0051984)4.41876354
22nuclear pore complex assembly (GO:0051292)4.40371013
23sister chromatid segregation (GO:0000819)4.36423024
24maturation of 5.8S rRNA (GO:0000460)4.32572289
25mitotic nuclear envelope disassembly (GO:0007077)4.29416376
26negative regulation of meiosis (GO:0045835)4.26543279
27DNA damage induced protein phosphorylation (GO:0006975)4.25984140
28protein localization to chromosome (GO:0034502)4.25508788
29DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.24732658
30regulation of meiosis (GO:0040020)4.23695640
31protein K6-linked ubiquitination (GO:0085020)4.21672582
32CENP-A containing nucleosome assembly (GO:0034080)4.19002271
33positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.18358465
34positive regulation of mitotic sister chromatid separation (GO:1901970)4.18358465
35positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.18358465
36oocyte maturation (GO:0001556)4.17403036
37male meiosis (GO:0007140)4.16252057
38chromatin remodeling at centromere (GO:0031055)4.15718436
39DNA damage response, signal transduction resulting in transcription (GO:0042772)4.13294092
40regulation of mitotic spindle organization (GO:0060236)4.13174148
41nuclear pore organization (GO:0006999)4.12493494
42regulation of exit from mitosis (GO:0007096)4.07129488
43membrane disassembly (GO:0030397)4.04935350
44nuclear envelope disassembly (GO:0051081)4.04935350
45kinetochore organization (GO:0051383)4.03415126
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.03339462
47positive regulation of gamma-delta T cell activation (GO:0046645)4.03261067
48chromosome segregation (GO:0007059)4.02485953
49spindle checkpoint (GO:0031577)4.02217412
50histone exchange (GO:0043486)4.01454037
51DNA replication-independent nucleosome assembly (GO:0006336)3.99843419
52DNA replication-independent nucleosome organization (GO:0034724)3.99843419
53regulation of chromosome segregation (GO:0051983)3.98139535
54histone H2A ubiquitination (GO:0033522)3.93023836
55mitotic sister chromatid cohesion (GO:0007064)3.89027494
56regulation of retinoic acid receptor signaling pathway (GO:0048385)3.80590745
57DNA methylation involved in gamete generation (GO:0043046)3.79465143
58regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.71861516
59B cell receptor signaling pathway (GO:0050853)3.71087082
60kinetochore assembly (GO:0051382)3.69090148
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.65043481
62sister chromatid cohesion (GO:0007062)3.61826589
63mitotic spindle checkpoint (GO:0071174)3.60016222
64regulation of female gonad development (GO:2000194)3.58751915
65regulation of double-strand break repair via homologous recombination (GO:0010569)3.58219084
66inner cell mass cell proliferation (GO:0001833)3.57947580
67snRNA transcription (GO:0009301)3.56835061
68regulation of mitotic metaphase/anaphase transition (GO:0030071)3.56467362
69negative regulation of hormone metabolic process (GO:0032351)3.54177320
70negative regulation of hormone biosynthetic process (GO:0032353)3.54177320
71ribosome assembly (GO:0042255)3.53281906
72negative regulation of chromosome segregation (GO:0051985)3.50353361
73regulation of DNA methylation (GO:0044030)3.49210358
74regulation of histone H3-K27 methylation (GO:0061085)3.48733894
75DNA replication-dependent nucleosome organization (GO:0034723)3.46859345
76DNA replication-dependent nucleosome assembly (GO:0006335)3.46859345
77gene silencing by RNA (GO:0031047)3.46140495
78regulation of centrosome cycle (GO:0046605)3.45522345
79regulation of sister chromatid segregation (GO:0033045)3.45367751
80regulation of mitotic sister chromatid separation (GO:0010965)3.45367751
81regulation of mitotic sister chromatid segregation (GO:0033047)3.45367751
82negative regulation of mitotic sister chromatid separation (GO:2000816)3.44777825
83negative regulation of mitotic sister chromatid segregation (GO:0033048)3.44777825
84negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.44777825
85negative regulation of sister chromatid segregation (GO:0033046)3.44777825
86spindle assembly checkpoint (GO:0071173)3.40988904
87mitotic spindle assembly checkpoint (GO:0007094)3.40802781
88chromatin assembly or disassembly (GO:0006333)3.39908950
89B cell proliferation (GO:0042100)3.38194280
90negative regulation of histone methylation (GO:0031061)3.36761776
91regulation of centriole replication (GO:0046599)3.34565439
92maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.33784754
93response to peptidoglycan (GO:0032494)3.33529196
94synaptonemal complex assembly (GO:0007130)3.32949092
95meiotic cell cycle process (GO:1903046)3.32824914
96CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.32280484
97B cell mediated immunity (GO:0019724)3.31422633
98positive regulation of B cell differentiation (GO:0045579)3.30013649
99immunoglobulin mediated immune response (GO:0016064)3.29577196
100female gonad development (GO:0008585)3.29542722
101oogenesis (GO:0048477)3.29054730
102positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.27817448
103meiotic nuclear division (GO:0007126)3.26791896
104mitotic G2/M transition checkpoint (GO:0044818)3.25652895
105negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.25111653
106negative regulation of DNA-templated transcription, elongation (GO:0032785)3.25111653
107regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23711649
108regulation of meiotic cell cycle (GO:0051445)3.22134807
109male meiosis I (GO:0007141)3.20632607
110regulation of B cell differentiation (GO:0045577)3.20219708
111nuclear envelope organization (GO:0006998)3.19878965
112DNA methylation (GO:0006306)3.18849156
113DNA alkylation (GO:0006305)3.18849156
114regulation of B cell receptor signaling pathway (GO:0050855)3.12189362
115regulation of vitamin D biosynthetic process (GO:0060556)3.08792505
116mitotic G2 DNA damage checkpoint (GO:0007095)3.05657136
117negative regulation of interleukin-12 production (GO:0032695)3.00241884
118positive regulation of humoral immune response (GO:0002922)2.96916215
119defense response to protozoan (GO:0042832)2.95454802
120IMP biosynthetic process (GO:0006188)2.91347172
121regulation of histone H3-K9 methylation (GO:0051570)2.88498335
122response to protozoan (GO:0001562)2.87508162
123somatic hypermutation of immunoglobulin genes (GO:0016446)2.85713602
124somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85713602
125positive regulation of interleukin-2 production (GO:0032743)2.84518362
126negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.82297547
127positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.81094459
128positive regulation of B cell proliferation (GO:0030890)2.75986721
129isotype switching (GO:0045190)2.75388245
130somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.75388245
131somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.75388245
132negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.74537931
133regulation of interleukin-2 biosynthetic process (GO:0045076)2.74270364
134positive regulation of protein oligomerization (GO:0032461)2.74200597
135regulation of interferon-alpha production (GO:0032647)2.74187614
136cellular extravasation (GO:0045123)2.72148661
137positive regulation of interferon-alpha production (GO:0032727)2.71899949
138regulation of gamma-delta T cell activation (GO:0046643)2.69640962
139somatic recombination of immunoglobulin gene segments (GO:0016447)2.69042940
140B cell homeostasis (GO:0001782)2.68070103
141regulation of B cell proliferation (GO:0030888)2.66462941
142IMP metabolic process (GO:0046040)2.65649476
143transcription from mitochondrial promoter (GO:0006390)2.62937142
144regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.61785104
145negative regulation of DNA-dependent DNA replication (GO:2000104)2.60567739
146positive regulation of B cell activation (GO:0050871)2.60029562
147T cell migration (GO:0072678)2.59118020
148T cell lineage commitment (GO:0002360)2.57965512
149mitochondrial DNA replication (GO:0006264)2.57594077
150positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.57439344
151macrophage activation involved in immune response (GO:0002281)2.57118047
152pore complex assembly (GO:0046931)2.56755292
153regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.54501506
154regulation of mitotic spindle checkpoint (GO:1903504)2.54444792
155regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.54444792
156positive regulation of interferon-beta production (GO:0032728)2.54077700
157interferon-gamma-mediated signaling pathway (GO:0060333)2.53827265
158natural killer cell differentiation (GO:0001779)2.53146009
159modulation by symbiont of host defense response (GO:0052031)2.52824210
160modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.52824210
161modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.52824210
162positive regulation by organism of defense response of other organism involved in symbiotic interact2.52824210
163modulation by symbiont of host immune response (GO:0052553)2.52824210
164positive regulation by symbiont of host defense response (GO:0052509)2.52824210
165positive regulation of interleukin-10 production (GO:0032733)2.52491561
166positive regulation of B cell mediated immunity (GO:0002714)2.51636197
167positive regulation of immunoglobulin mediated immune response (GO:0002891)2.51636197
168neutrophil activation involved in immune response (GO:0002283)2.51586435
169regulation of fibroblast apoptotic process (GO:2000269)2.50223655
170regulation of chronic inflammatory response (GO:0002676)2.49182129
171folic acid-containing compound biosynthetic process (GO:0009396)2.47290872
172regulation of interferon-beta biosynthetic process (GO:0045357)2.46951548
173myeloid dendritic cell activation (GO:0001773)2.43649761
174germinal center formation (GO:0002467)2.42888439
175DNA strand elongation (GO:0022616)2.42815401
176B cell activation involved in immune response (GO:0002312)2.42701376
177activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.42446333
178regulation of interferon-gamma biosynthetic process (GO:0045072)2.42213130
179somatic diversification of immunoglobulins (GO:0016445)2.41761544
180NIK/NF-kappaB signaling (GO:0038061)2.41581671
181leukocyte aggregation (GO:0070486)2.41225729
182cellular response to arsenic-containing substance (GO:0071243)2.40357878
183negative regulation of DNA recombination (GO:0045910)2.39484918
184positive regulation of cytokine biosynthetic process (GO:0042108)2.39266223
185regulation of B cell activation (GO:0050864)2.38874724
186DNA strand elongation involved in DNA replication (GO:0006271)2.35502474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.14687032
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.94869818
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.54652241
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.19930958
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.76390781
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.75618119
7AR_21909140_ChIP-Seq_LNCAP_Human3.52411618
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.10080906
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.97868130
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.97475740
11GATA1_22025678_ChIP-Seq_K562_Human2.91975714
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.85727045
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.71240323
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.70927466
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.65583533
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.64661453
17KAP1_22055183_ChIP-Seq_ESCs_Mouse2.55966853
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.53797946
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.49721247
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39910008
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.38394421
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31866593
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.28490708
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14835857
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.09478839
26IRF8_27001747_Chip-Seq_BMDM_Mouse2.09451872
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07596366
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06756752
29MYC_18555785_ChIP-Seq_MESCs_Mouse2.00030830
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99602170
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.98124524
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97890137
33SPI1_23547873_ChIP-Seq_NB4_Human1.97667854
34MYB_26560356_Chip-Seq_TH2_Human1.97341285
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.96012309
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95646825
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.89064593
38ELK1_19687146_ChIP-ChIP_HELA_Human1.87929785
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.84765047
40* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82570051
41MYB_26560356_Chip-Seq_TH1_Human1.81008898
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.76772449
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76453251
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.70151306
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.69220217
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66997659
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.63889067
48* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.60247457
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58824592
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.57973892
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57351676
52SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.53601901
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53137818
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.52138344
55CIITA_25753668_ChIP-Seq_RAJI_Human1.51104724
56* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50175393
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49435701
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48036841
59TFEB_21752829_ChIP-Seq_HELA_Human1.46367077
60MYC_18940864_ChIP-ChIP_HL60_Human1.46124188
61* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45492793
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43561293
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40015882
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39837408
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36887435
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36760310
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.35446893
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.35446893
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.35446893
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34579301
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34200291
72NANOG_21062744_ChIP-ChIP_HESCs_Human1.34077137
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.33414117
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33278189
75* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32880518
76RUNX_20019798_ChIP-Seq_JUKART_Human1.32301520
77KDM5A_27292631_Chip-Seq_BREAST_Human1.31558039
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.29101348
79DCP1A_22483619_ChIP-Seq_HELA_Human1.27610048
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26820889
81CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24204574
82FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23889252
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22917767
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21683068
85* EST1_17652178_ChIP-ChIP_JURKAT_Human1.21494908
86MAF_26560356_Chip-Seq_TH1_Human1.20019753
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19469258
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19079774
89PU_27001747_Chip-Seq_BMDM_Mouse1.18606782
90ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18513189
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15899488
92VDR_23849224_ChIP-Seq_CD4+_Human1.14605402
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13630300
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12847696
95GABP_19822575_ChIP-Seq_HepG2_Human1.12104969
96* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.11523466
97IGF1R_20145208_ChIP-Seq_DFB_Human1.10781372
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09567717
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09293618
100* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08581341
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07549245
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05800266
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05467585
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05406528
105VDR_24763502_ChIP-Seq_THP-1_Human1.04179553
106* FUS_26573619_Chip-Seq_HEK293_Human1.03567692
107GATA3_27048872_Chip-Seq_THYMUS_Human1.02874879
108* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02587028
109MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02367334
110RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00958528
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00766462
112ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00759976
113GATA3_26560356_Chip-Seq_TH2_Human0.98945919
114E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98660022
115* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98331040
116XRN2_22483619_ChIP-Seq_HELA_Human0.96744864
117PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95994884
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95136669
119VDR_24787735_ChIP-Seq_THP-1_Human0.95014642
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94134201
121FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93312082
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93085485
123* ETS1_20019798_ChIP-Seq_JURKAT_Human0.92821875
124* KAP1_27257070_Chip-Seq_ESCs_Mouse0.92759091
125SALL4_22934838_ChIP-ChIP_CD34+_Human0.92745489
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92558352
127HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91509345
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91260638
129* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90498405
130JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.90497064
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90256999
132FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89093985
133FOXP3_21729870_ChIP-Seq_TREG_Human0.87959631
134* EWS_26573619_Chip-Seq_HEK293_Human0.87100034
135RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87077640
136NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86570476
137LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86073039
138GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85188567
139HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.85171554
140MYC_22102868_ChIP-Seq_BL_Human0.84271228
141CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82751367
142* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.82048016
143TTF2_22483619_ChIP-Seq_HELA_Human0.82022756
144NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.81232262
145CDX2_22108803_ChIP-Seq_LS180_Human0.80368246
146TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79649595
147SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79212059
148RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.78672824
149TCF3_18692474_ChIP-Seq_MEFs_Mouse0.78065629
150POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76319859
151ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.75003956
152RNF2_27304074_Chip-Seq_NSC_Mouse0.73210031
153FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72928028
154SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72875289
155FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.72854852
156SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72418621
157SOX2_18555785_ChIP-Seq_MESCs_Mouse0.71732898
158POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.71312767
159CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70829593

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.14102785
2MP0003718_maternal_effect4.60652572
3MP0010094_abnormal_chromosome_stability4.33045438
4MP0008877_abnormal_DNA_methylation4.03979048
5MP0003111_abnormal_nucleus_morphology3.89659480
6MP0003077_abnormal_cell_cycle3.75818467
7MP0004957_abnormal_blastocyst_morpholog3.54799054
8MP0005451_abnormal_body_composition3.53523947
9MP0001835_abnormal_antigen_presentation3.30327436
10MP0002102_abnormal_ear_morphology3.16516131
11MP0008057_abnormal_DNA_replication3.03241416
12MP0003303_peritoneal_inflammation2.93879695
13MP0003123_paternal_imprinting2.92226906
14MP0002653_abnormal_ependyma_morphology2.88087831
15MP0005671_abnormal_response_to2.86419868
16MP0001790_abnormal_immune_system2.80257997
17MP0005387_immune_system_phenotype2.80257997
18MP0001800_abnormal_humoral_immune2.73261199
19MP0000685_abnormal_immune_system2.65083453
20MP0005000_abnormal_immune_tolerance2.62638212
21MP0003646_muscle_fatigue2.53737482
22MP0008007_abnormal_cellular_replicative2.51220298
23MP0003787_abnormal_imprinting2.51096325
24MP0002452_abnormal_antigen_presenting2.47216777
25MP0003436_decreased_susceptibility_to2.39490136
26MP0008058_abnormal_DNA_repair2.29866755
27MP0002148_abnormal_hypersensitivity_rea2.28083506
28MP0008932_abnormal_embryonic_tissue2.26885643
29MP0003121_genomic_imprinting2.22991001
30MP0001730_embryonic_growth_arrest2.22122203
31MP0002723_abnormal_immune_serum2.16349966
32MP0001929_abnormal_gametogenesis2.16088278
33MP0006292_abnormal_olfactory_placode2.15613639
34MP0000350_abnormal_cell_proliferation2.12955877
35MP0001119_abnormal_female_reproductive2.12927311
36MP0009785_altered_susceptibility_to2.12104817
37MP0002420_abnormal_adaptive_immunity2.08747505
38MP0002210_abnormal_sex_determination2.08271650
39MP0002398_abnormal_bone_marrow2.05867991
40MP0003699_abnormal_female_reproductive2.05084197
41MP0001819_abnormal_immune_cell2.02933556
42MP0001853_heart_inflammation2.02525087
43MP0000653_abnormal_sex_gland1.97282667
44MP0002419_abnormal_innate_immunity1.94738873
45MP0005395_other_phenotype1.93383290
46MP0010307_abnormal_tumor_latency1.86378948
47MP0002006_tumorigenesis1.85566540
48MP0000689_abnormal_spleen_morphology1.84588735
49MP0004264_abnormal_extraembryonic_tissu1.83334463
50MP0003937_abnormal_limbs/digits/tail_de1.82475294
51MP0002085_abnormal_embryonic_tissue1.81062182
52MP0005380_embryogenesis_phenotype1.79176339
53MP0001672_abnormal_embryogenesis/_devel1.79176339
54MP0000716_abnormal_immune_system1.78709785
55MP0001697_abnormal_embryo_size1.78215837
56MP0005408_hypopigmentation1.75686032
57MP0002084_abnormal_developmental_patter1.75009292
58MP0005025_abnormal_response_to1.71374601
59MP0001145_abnormal_male_reproductive1.61568255
60MP0002722_abnormal_immune_system1.60635821
61MP0002405_respiratory_system_inflammati1.57697826
62MP0009764_decreased_sensitivity_to1.55191339
63MP0002429_abnormal_blood_cell1.54426452
64MP0002166_altered_tumor_susceptibility1.54228305
65MP0003890_abnormal_embryonic-extraembry1.46939910
66MP0002877_abnormal_melanocyte_morpholog1.45199217
67MP0003984_embryonic_growth_retardation1.43949652
68MP0003300_gastrointestinal_ulcer1.41583320
69MP0002088_abnormal_embryonic_growth/wei1.38300176
70MP0006082_CNS_inflammation1.37277147
71MP0000703_abnormal_thymus_morphology1.36174070
72MP0002249_abnormal_larynx_morphology1.34974962
73MP0003315_abnormal_perineum_morphology1.33830523
74MP0001845_abnormal_inflammatory_respons1.32527318
75MP0004185_abnormal_adipocyte_glucose1.32473123
76MP0002009_preneoplasia1.32107745
77MP0002161_abnormal_fertility/fecundity1.30296297
78MP0000579_abnormal_nail_morphology1.26652981
79MP0004510_myositis1.25115814
80MP0002086_abnormal_extraembryonic_tissu1.24726797
81MP0002080_prenatal_lethality1.18916054
82MP0002138_abnormal_hepatobiliary_system1.18416761
83MP0004947_skin_inflammation1.17452297
84MP0003448_altered_tumor_morphology1.16875031
85MP0010155_abnormal_intestine_physiology1.15193530
86MP0002254_reproductive_system_inflammat1.14304945
87MP0002019_abnormal_tumor_incidence1.12743669
88MP0010234_abnormal_vibrissa_follicle1.10825001
89MP0001545_abnormal_hematopoietic_system1.08163954
90MP0005397_hematopoietic_system_phenotyp1.08163954
91MP0001915_intracranial_hemorrhage1.06798295
92MP0003698_abnormal_male_reproductive1.06515633
93MP0009278_abnormal_bone_marrow1.04647514
94MP0001529_abnormal_vocalization1.04420138
95MP0000462_abnormal_digestive_system1.04374543
96MP0005464_abnormal_platelet_physiology1.02371914
97MP0003172_abnormal_lysosome_physiology1.02207647
98MP0003786_premature_aging1.01895550
99MP0006035_abnormal_mitochondrial_morpho1.01706541
100MP0003724_increased_susceptibility_to0.98023841
101MP0003806_abnormal_nucleotide_metabolis0.96019019
102MP0008469_abnormal_protein_level0.95919521
103MP0002396_abnormal_hematopoietic_system0.94491393
104MP0003755_abnormal_palate_morphology0.92992556
105MP0000490_abnormal_crypts_of0.91029352
106MP0000313_abnormal_cell_death0.91000048
107MP0005076_abnormal_cell_differentiation0.90685621
108MP0005621_abnormal_cell_physiology0.87981096
109MP0001849_ear_inflammation0.87815717
110MP0002332_abnormal_exercise_endurance0.85752923
111MP0003091_abnormal_cell_migration0.85659710
112MP0002139_abnormal_hepatobiliary_system0.84201991
113MP0003861_abnormal_nervous_system0.83750882
114MP0000465_gastrointestinal_hemorrhage0.83654356
115MP0000566_synostosis0.83097114
116MP0000343_altered_response_to0.80524185
117MP0005389_reproductive_system_phenotype0.80286283
118MP0002998_abnormal_bone_remodeling0.79550994
119MP0001873_stomach_inflammation0.79473486
120MP0005266_abnormal_metabolism0.78619680
121MP0009672_abnormal_birth_weight0.78032360
122MP0005310_abnormal_salivary_gland0.77813311
123MP0000432_abnormal_head_morphology0.77000747
124MP0005166_decreased_susceptibility_to0.76940448
125MP0000858_altered_metastatic_potential0.76683162
126MP0001727_abnormal_embryo_implantation0.75654053
127MP0001919_abnormal_reproductive_system0.74899504
128MP0003119_abnormal_digestive_system0.74890888
129MP0010352_gastrointestinal_tract_polyps0.72977793
130MP0005384_cellular_phenotype0.72706736
131MP0002163_abnormal_gland_morphology0.71483067
132MP0006072_abnormal_retinal_apoptosis0.70736876
133MP0008260_abnormal_autophagy0.70386657
134MP0001533_abnormal_skeleton_physiology0.69165905
135MP0002160_abnormal_reproductive_system0.68784780
136MP0003453_abnormal_keratinocyte_physiol0.67808913
137MP0003935_abnormal_craniofacial_develop0.67040437
138MP0004197_abnormal_fetal_growth/weight/0.66752696
139MP0000639_abnormal_adrenal_gland0.66628860
140MP0003221_abnormal_cardiomyocyte_apopto0.66132066
141MP0005647_abnormal_sex_gland0.64973359
142MP0005187_abnormal_penis_morphology0.60499959
143MP0003763_abnormal_thymus_physiology0.58821408
144MP0000627_abnormal_mammary_gland0.58380017
145MP0001851_eye_inflammation0.57679378
146MP0000427_abnormal_hair_cycle0.56434849
147MP0003936_abnormal_reproductive_system0.56401814
148MP0003950_abnormal_plasma_membrane0.55885884
149MP0001286_abnormal_eye_development0.53410452
150MP0010030_abnormal_orbit_morphology0.52321030
151MP0003656_abnormal_erythrocyte_physiolo0.51270862
152MP0009703_decreased_birth_body0.48086330
153MP0002925_abnormal_cardiovascular_devel0.47585547
154MP0002114_abnormal_axial_skeleton0.47524442
155MP0002177_abnormal_outer_ear0.47170296
156MP0002116_abnormal_craniofacial_bone0.47089585
157MP0002233_abnormal_nose_morphology0.46918659
158MP0003705_abnormal_hypodermis_morpholog0.45382097
159MP0005248_abnormal_Harderian_gland0.44806874
160MP0009333_abnormal_splenocyte_physiolog0.44616214
161MP0004808_abnormal_hematopoietic_stem0.42698006
162MP0001485_abnormal_pinna_reflex0.42401010

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.48450969
2Papillary thyroid carcinoma (HP:0002895)5.43278535
3Birth length less than 3rd percentile (HP:0003561)5.25737351
4Chromosomal breakage induced by crosslinking agents (HP:0003221)5.14668808
5Abnormality of the labia minora (HP:0012880)4.98346275
6Facial hemangioma (HP:0000329)4.92052786
7Male infertility (HP:0003251)4.86387571
8Cortical dysplasia (HP:0002539)4.52368745
9Breast hypoplasia (HP:0003187)4.45578761
10Gastrointestinal stroma tumor (HP:0100723)4.10181311
11Patellar aplasia (HP:0006443)4.08406600
12Mediastinal lymphadenopathy (HP:0100721)3.89093810
13IgM deficiency (HP:0002850)3.81417458
14Aplasia/Hypoplasia of the patella (HP:0006498)3.75038620
15Shawl scrotum (HP:0000049)3.74571721
16Abnormality of chromosome stability (HP:0003220)3.71441948
17Recurrent viral infections (HP:0004429)3.70677646
18Capillary hemangiomas (HP:0005306)3.65126278
19Agnosia (HP:0010524)3.59654318
20T lymphocytopenia (HP:0005403)3.56004959
21IgA deficiency (HP:0002720)3.54414276
22Progressive external ophthalmoplegia (HP:0000590)3.52793892
23Agammaglobulinemia (HP:0004432)3.52756088
24Recurrent bacterial skin infections (HP:0005406)3.44249949
25B lymphocytopenia (HP:0010976)3.42045099
26Stomatitis (HP:0010280)3.35980822
27Abnormality of T cell number (HP:0011839)3.25283956
28Aplasia/Hypoplasia of the uvula (HP:0010293)3.24679333
29IgG deficiency (HP:0004315)3.22515080
30Abnormality of B cell number (HP:0010975)3.18547736
31Supernumerary spleens (HP:0009799)3.17069177
32Abnormality of the preputium (HP:0100587)3.17067653
33Thyroid carcinoma (HP:0002890)3.13892062
34Lymphoma (HP:0002665)3.10573144
35Lymphopenia (HP:0001888)3.09349424
36Meckel diverticulum (HP:0002245)3.08850937
37Oligodactyly (hands) (HP:0001180)3.07783041
38Meningitis (HP:0001287)3.05626682
39Vasculitis (HP:0002633)3.04382196
40Adrenal hypoplasia (HP:0000835)3.01966465
41Flat capital femoral epiphysis (HP:0003370)2.97162842
42Oligodactyly (HP:0012165)2.96656151
43Abnormality of the fingertips (HP:0001211)2.95697038
44Acute myeloid leukemia (HP:0004808)2.95287407
45Breast aplasia (HP:0100783)2.92586702
46Ectopic kidney (HP:0000086)2.90831960
47Absent radius (HP:0003974)2.90765720
48Sandal gap (HP:0001852)2.90561813
49Impulsivity (HP:0100710)2.89148168
50Abnormality of chromosome segregation (HP:0002916)2.86895654
51Abnormality of the ileum (HP:0001549)2.86819365
52Recurrent abscess formation (HP:0002722)2.85299102
53Abnormality of cells of the lymphoid lineage (HP:0012140)2.84047711
54Aplasia/Hypoplasia of the breasts (HP:0010311)2.81239765
55Amaurosis fugax (HP:0100576)2.79121717
56Carpal bone hypoplasia (HP:0001498)2.78950032
57Abnormality of the lumbar spine (HP:0100712)2.78455582
58Recurrent sinusitis (HP:0011108)2.76433024
59Absent forearm bone (HP:0003953)2.75382593
60Aplasia involving forearm bones (HP:0009822)2.75382593
61Abnormality of the prostate (HP:0008775)2.73700177
62Abnormality of lateral ventricle (HP:0030047)2.71492840
63Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.70988803
64Sparse lateral eyebrow (HP:0005338)2.70645817
65Secondary amenorrhea (HP:0000869)2.69510044
66Rhabdomyosarcoma (HP:0002859)2.68043941
67Panhypogammaglobulinemia (HP:0003139)2.67389552
68Abnormality of macrophages (HP:0004311)2.66933285
69Small intestinal stenosis (HP:0012848)2.64109282
70Duodenal stenosis (HP:0100867)2.64109282
71Sloping forehead (HP:0000340)2.56745235
72Autoimmune hemolytic anemia (HP:0001890)2.56644302
73Myelodysplasia (HP:0002863)2.55642154
74Leukopenia (HP:0001882)2.55041473
75Neoplasm of the oral cavity (HP:0100649)2.54452750
76Medulloblastoma (HP:0002885)2.53663085
77Recurrent bronchitis (HP:0002837)2.53556861
78Encephalitis (HP:0002383)2.52276000
79Abnormality of T cells (HP:0002843)2.51402558
80Osteomyelitis (HP:0002754)2.50479692
81Lip pit (HP:0100267)2.48482311
82Prostate neoplasm (HP:0100787)2.46932806
83Short thumb (HP:0009778)2.46077887
84Multiple enchondromatosis (HP:0005701)2.45515139
85Increased IgM level (HP:0003496)2.43148716
86Aplasia/Hypoplasia of the sternum (HP:0006714)2.42681942
87Premature ovarian failure (HP:0008209)2.40950330
88Cafe-au-lait spot (HP:0000957)2.40184577
89Recurrent fungal infections (HP:0002841)2.40079824
90Overlapping toe (HP:0001845)2.39659788
91Optic neuritis (HP:0100653)2.38140222
92Retrobulbar optic neuritis (HP:0100654)2.38140222
93Combined immunodeficiency (HP:0005387)2.36468325
94Vacuolated lymphocytes (HP:0001922)2.35372815
95Autoimmune thrombocytopenia (HP:0001973)2.34848775
96Chronic bronchitis (HP:0004469)2.33562045
97Cellulitis (HP:0100658)2.32647707
98Abnormality of glycolipid metabolism (HP:0010969)2.32387760
99Abnormality of liposaccharide metabolism (HP:0010968)2.32387760
100Abnormality of glycosphingolipid metabolism (HP:0004343)2.32387760
101Chronic diarrhea (HP:0002028)2.31954588
102Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.31772492
103Pulmonary infiltrates (HP:0002113)2.30715553
104Basal cell carcinoma (HP:0002671)2.27241367
105Cystic hygroma (HP:0000476)2.26816892
106Microvesicular hepatic steatosis (HP:0001414)2.26348271
107Abnormality of the carotid arteries (HP:0005344)2.23780216
108Disinhibition (HP:0000734)2.22717168
109Nephroblastoma (Wilms tumor) (HP:0002667)2.20435809
110Pulmonary fibrosis (HP:0002206)2.18949078
111Abnormal delayed hypersensitivity skin test (HP:0002963)2.18069204
112Chronic mucocutaneous candidiasis (HP:0002728)2.17453494
113Recurrent cutaneous fungal infections (HP:0011370)2.17453494
114Abnormality of the duodenum (HP:0002246)2.15064281
115Clubbing of toes (HP:0100760)2.15059578
116Restrictive lung disease (HP:0002091)2.14542957
117Cellular immunodeficiency (HP:0005374)2.11404095
118Eczematoid dermatitis (HP:0000976)2.10936907
119Abnormality of the proximal phalanges of the hand (HP:0009834)2.09499011
120Hypergonadotropic hypogonadism (HP:0000815)2.09080943
121Inflammation of the large intestine (HP:0002037)2.08399249
122Rib fusion (HP:0000902)2.08239872
123Papilloma (HP:0012740)2.08088820
124Verrucae (HP:0200043)2.08088820
125Fatigue (HP:0012378)2.05304592
126Horseshoe kidney (HP:0000085)2.04917424
127Aplastic anemia (HP:0001915)2.04854090
128Keratoconjunctivitis sicca (HP:0001097)2.04119467
129Abnormal spermatogenesis (HP:0008669)2.03994785
130Neoplasm of striated muscle (HP:0009728)2.03542473
131Embryonal renal neoplasm (HP:0011794)2.02434640
132Recurrent skin infections (HP:0001581)2.02016173
133Recurrent pneumonia (HP:0006532)2.01766963
134Chronic obstructive pulmonary disease (HP:0006510)1.99786948
135Obstructive lung disease (HP:0006536)1.99786948
136Ependymoma (HP:0002888)1.99724832
137Abnormality of T cell physiology (HP:0011840)1.99498439
138Abnormality of the phalanges of the hallux (HP:0010057)1.99470338
139Abnormal lung lobation (HP:0002101)1.95590883
140Aplasia/Hypoplasia of the earlobes (HP:0009906)1.94116262
141Wrist flexion contracture (HP:0001239)1.93756253
142Recurrent lower respiratory tract infections (HP:0002783)1.92207659
143Nausea (HP:0002018)1.91893330
144Primary amenorrhea (HP:0000786)1.91437035
145Prominent nose (HP:0000448)1.90621474
146Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89668374
147Urticaria (HP:0001025)1.88902508
148Gastrointestinal inflammation (HP:0004386)1.88845996
149Limb hypertonia (HP:0002509)1.86552049
150Microglossia (HP:0000171)1.86448480
151Increased cerebral lipofuscin (HP:0011813)1.85950517
152Thrombocytosis (HP:0001894)1.85706488
153Oral leukoplakia (HP:0002745)1.85368787
154Colitis (HP:0002583)1.84199883
155Neutropenia (HP:0001875)1.83088911
156Aplasia/Hypoplasia involving the musculature (HP:0001460)1.80366433
157Orchitis (HP:0100796)1.80353365
158Azoospermia (HP:0000027)1.78641517
159Bone marrow hypocellularity (HP:0005528)1.78395328
160Arterial thrombosis (HP:0004420)1.78064946
161Volvulus (HP:0002580)1.77539266
162Heterotopia (HP:0002282)1.76682057
163Delayed puberty (HP:0000823)1.74904742
164Colon cancer (HP:0003003)1.74146370
165Abnormality of the labia (HP:0000058)1.73343836
166Microtia (HP:0008551)1.73260144
167Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.70262840
168Short 1st metacarpal (HP:0010034)1.70262840
169Abnormality of the epiphysis of the femoral head (HP:0010574)1.69364487
170Pancreatic fibrosis (HP:0100732)1.67615907
171Infertility (HP:0000789)1.66667402
172Triphalangeal thumb (HP:0001199)1.65988639
173Transitional cell carcinoma of the bladder (HP:0006740)1.60858179
174Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60342233
175Insulin-resistant diabetes mellitus (HP:0000831)1.59347213
176Astrocytoma (HP:0009592)1.59045565
177Abnormality of the astrocytes (HP:0100707)1.59045565
178Abnormality of cochlea (HP:0000375)1.58639586
179Spontaneous abortion (HP:0005268)1.57825003
180Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.55416512

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.27569145
2CDC73.79173797
3EIF2AK33.77792159
4TSSK63.68778355
5LATS23.68287524
6PLK43.53187485
7STK38L3.29867427
8TTK3.29381414
9TAOK33.23055773
10MAP3K63.11290150
11BRAF2.74053717
12KSR22.66251273
13EEF2K2.60014142
14ERBB42.54582330
15MAP4K12.44170111
16MAP3K92.39555505
17PRPF4B2.37808357
18RIPK42.37424738
19NEK22.36948142
20MAP3K142.36918541
21BLK2.20304307
22MUSK2.17639401
23MKNK12.15566941
24CHEK22.06127790
25RAF12.01378872
26STK31.94127524
27IRAK31.89707026
28TAOK11.88261389
29CDK121.86922359
30SIK31.78950184
31MOS1.69919356
32NME21.69250342
33PLK11.69133557
34MELK1.62137334
35IRAK41.59387532
36MAP3K131.58042919
37WEE11.56484780
38MAP3K101.56143724
39SRPK11.55982459
40TEC1.54410531
41BUB11.54364797
42ACVR1B1.50943960
43ARAF1.50276284
44MAPKAPK31.46627080
45MST41.44102866
46STK101.43346082
47ZAK1.42191708
48KSR11.41449028
49TAOK21.38606584
50CDK81.38322785
51BRD41.31238501
52CDK91.30382374
53ALK1.29437609
54IKBKB1.27603219
55BTK1.26060944
56EIF2AK11.23426263
57MAP3K81.22185913
58BRSK21.22051706
59MATK1.21765608
60SYK1.19931115
61AURKB1.19422843
62IKBKE1.17672574
63PAK61.15710252
64PLK31.15068096
65PRKD31.11820560
66MAP3K41.10609725
67CHEK11.07413619
68TRIM281.06562187
69MARK31.05723487
70TNIK1.05031119
71FGR1.05029214
72TAF11.03592991
73TXK1.03481945
74RPS6KB20.97360075
75TYK20.97359614
76NEK10.95503236
77LYN0.95169125
78ITK0.94795647
79JAK30.89480337
80EIF2AK20.89297117
81ATM0.88244701
82GRK70.87132400
83TYRO30.85860070
84BMPR20.85056849
85IRAK20.84407782
86DYRK20.82938674
87CDK70.82246816
88BMPR1B0.81543186
89CDK40.80908639
90AURKA0.79264943
91STK380.78764342
92BRSK10.78728873
93CSK0.78411752
94MAPK130.75263995
95CLK10.75033043
96ATR0.74765461
97JAK10.68134055
98ERBB30.67666676
99VRK10.66904701
100HCK0.65999233
101PASK0.65346311
102ABL20.64925392
103TBK10.64118742
104IRAK10.63537663
105CDK20.62796455
106CSF1R0.61352027
107PRKAA10.60979125
108JAK20.60452337
109TGFBR10.60071996
110FLT30.59975426
111CDK30.59531865
112STK240.59524035
113CHUK0.56575398
114PRKAA20.54778438
115CSNK1G10.54603647
116MAP3K50.54377069
117CDK10.54008622
118DYRK30.51421033
119MAP3K120.50571333
120RPS6KA40.49405619
121NUAK10.48205732
122SMG10.47185524
123PIK3CG0.46574836
124LCK0.46518681
125MAP2K70.45733322
126MAP2K30.45668962
127PDK20.44561510
128MKNK20.43807054
129PRKD20.43522620
130MAP3K10.42983579
131RET0.40107938
132TRPM70.39936592
133CSNK1G20.37850716
134AKT30.37111801
135DMPK0.36110690
136STK40.34909060
137PRKCI0.32439170
138NEK90.31518314
139MAP2K40.31348576
140MAPKAPK50.30822574
141NLK0.30523261
142MAPK100.30300659
143CSNK1D0.29687258
144ABL10.25934936
145CSNK1E0.25750511
146MARK20.25317621
147SGK20.25239096
148PAK10.25010179
149CSNK1G30.24799021
150MAPK140.23300796
151TESK20.22408536
152NTRK20.21456163
153MTOR0.21036585
154GSK3B0.20869655
155PIM10.20499067
156PDK30.20064385
157PDK40.20064385
158CDK60.19086401

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041104.45910964
2Basal transcription factors_Homo sapiens_hsa030223.63403383
3RNA degradation_Homo sapiens_hsa030183.42761114
4Asthma_Homo sapiens_hsa053103.25511195
5Allograft rejection_Homo sapiens_hsa053303.25159652
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17825301
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.05392055
8RNA transport_Homo sapiens_hsa030133.03346225
9Homologous recombination_Homo sapiens_hsa034403.02748216
10Autoimmune thyroid disease_Homo sapiens_hsa053202.88791917
11Graft-versus-host disease_Homo sapiens_hsa053322.86183392
12Fanconi anemia pathway_Homo sapiens_hsa034602.82077179
13RNA polymerase_Homo sapiens_hsa030202.72280085
14DNA replication_Homo sapiens_hsa030302.69069184
15Type I diabetes mellitus_Homo sapiens_hsa049402.57073958
16Vitamin B6 metabolism_Homo sapiens_hsa007502.54854404
17Mismatch repair_Homo sapiens_hsa034302.54513067
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.52871711
19p53 signaling pathway_Homo sapiens_hsa041152.46670598
20Leishmaniasis_Homo sapiens_hsa051402.36260308
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.34988568
22Primary immunodeficiency_Homo sapiens_hsa053402.31252945
23Oocyte meiosis_Homo sapiens_hsa041142.30107723
24B cell receptor signaling pathway_Homo sapiens_hsa046622.27308489
25Non-homologous end-joining_Homo sapiens_hsa034502.23484897
26NF-kappa B signaling pathway_Homo sapiens_hsa040642.22219845
27Base excision repair_Homo sapiens_hsa034102.04351288
28Ovarian steroidogenesis_Homo sapiens_hsa049132.03871723
29Viral myocarditis_Homo sapiens_hsa054162.03700994
30Nucleotide excision repair_Homo sapiens_hsa034201.99898987
31Circadian rhythm_Homo sapiens_hsa047101.94641036
32Antigen processing and presentation_Homo sapiens_hsa046121.87859762
33mRNA surveillance pathway_Homo sapiens_hsa030151.84633335
34Rheumatoid arthritis_Homo sapiens_hsa053231.82510917
35Legionellosis_Homo sapiens_hsa051341.77567675
36TGF-beta signaling pathway_Homo sapiens_hsa043501.75570871
37Hematopoietic cell lineage_Homo sapiens_hsa046401.71376253
38Staphylococcus aureus infection_Homo sapiens_hsa051501.68997694
39Pancreatic cancer_Homo sapiens_hsa052121.66299312
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.65728587
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63910571
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61067963
43Tuberculosis_Homo sapiens_hsa051521.60651693
44Spliceosome_Homo sapiens_hsa030401.52838471
45MicroRNAs in cancer_Homo sapiens_hsa052061.51340432
46Osteoclast differentiation_Homo sapiens_hsa043801.51332921
47Dorso-ventral axis formation_Homo sapiens_hsa043201.48683057
48Measles_Homo sapiens_hsa051621.45518206
49Linoleic acid metabolism_Homo sapiens_hsa005911.44544900
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38550969
51Toxoplasmosis_Homo sapiens_hsa051451.37538182
52One carbon pool by folate_Homo sapiens_hsa006701.30835723
53Pyrimidine metabolism_Homo sapiens_hsa002401.29889795
54Proteasome_Homo sapiens_hsa030501.26620022
55Colorectal cancer_Homo sapiens_hsa052101.25463188
56TNF signaling pathway_Homo sapiens_hsa046681.22459994
57Thyroid cancer_Homo sapiens_hsa052161.21816812
58Ether lipid metabolism_Homo sapiens_hsa005651.19313059
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12367426
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12209169
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.11346674
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09652551
63T cell receptor signaling pathway_Homo sapiens_hsa046601.07448344
64Choline metabolism in cancer_Homo sapiens_hsa052311.01794523
65mTOR signaling pathway_Homo sapiens_hsa041500.97778601
66Prolactin signaling pathway_Homo sapiens_hsa049170.96484320
67Purine metabolism_Homo sapiens_hsa002300.93765995
68Hippo signaling pathway_Homo sapiens_hsa043900.91437630
69Renal cell carcinoma_Homo sapiens_hsa052110.88806463
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88645416
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87692502
72FoxO signaling pathway_Homo sapiens_hsa040680.87169017
73Herpes simplex infection_Homo sapiens_hsa051680.86059607
74Endometrial cancer_Homo sapiens_hsa052130.85312307
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84843905
76GnRH signaling pathway_Homo sapiens_hsa049120.81847468
77Adherens junction_Homo sapiens_hsa045200.81663662
78Malaria_Homo sapiens_hsa051440.81037212
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80343358
80Pentose phosphate pathway_Homo sapiens_hsa000300.79027377
81Viral carcinogenesis_Homo sapiens_hsa052030.78233078
82Other glycan degradation_Homo sapiens_hsa005110.76021199
83Epstein-Barr virus infection_Homo sapiens_hsa051690.72742617
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72611026
85HTLV-I infection_Homo sapiens_hsa051660.70312121
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70025810
87Small cell lung cancer_Homo sapiens_hsa052220.68402141
88VEGF signaling pathway_Homo sapiens_hsa043700.68142007
89Non-small cell lung cancer_Homo sapiens_hsa052230.67199152
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.66033270
91Biosynthesis of amino acids_Homo sapiens_hsa012300.65512458
92Chemokine signaling pathway_Homo sapiens_hsa040620.65121366
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64048717
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63938303
95Phagosome_Homo sapiens_hsa041450.62940551
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61767391
97Prostate cancer_Homo sapiens_hsa052150.61193561
98Pertussis_Homo sapiens_hsa051330.59394231
99Hepatitis B_Homo sapiens_hsa051610.57624625
100Acute myeloid leukemia_Homo sapiens_hsa052210.56921769
101Chronic myeloid leukemia_Homo sapiens_hsa052200.56911720
102Bladder cancer_Homo sapiens_hsa052190.56046340
103Lysine degradation_Homo sapiens_hsa003100.54645552
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50881232
105Notch signaling pathway_Homo sapiens_hsa043300.50281047
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49483170
107Hepatitis C_Homo sapiens_hsa051600.49031224
108Salmonella infection_Homo sapiens_hsa051320.48221411
109Lysosome_Homo sapiens_hsa041420.47048892
110African trypanosomiasis_Homo sapiens_hsa051430.45821520
111Selenocompound metabolism_Homo sapiens_hsa004500.45182014
112Systemic lupus erythematosus_Homo sapiens_hsa053220.43653785
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40995795
114ErbB signaling pathway_Homo sapiens_hsa040120.40993133
115Long-term depression_Homo sapiens_hsa047300.40312412
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39958627
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38909293
118Wnt signaling pathway_Homo sapiens_hsa043100.36877493
119Ras signaling pathway_Homo sapiens_hsa040140.36613963
120Inositol phosphate metabolism_Homo sapiens_hsa005620.35538174
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35380745
122Estrogen signaling pathway_Homo sapiens_hsa049150.35365544
123Glioma_Homo sapiens_hsa052140.34650408
124Melanoma_Homo sapiens_hsa052180.34313887
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.33994672
126Protein export_Homo sapiens_hsa030600.33810698
127Pathways in cancer_Homo sapiens_hsa052000.33713726
128Folate biosynthesis_Homo sapiens_hsa007900.33564580
129HIF-1 signaling pathway_Homo sapiens_hsa040660.32472474
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31649142
131MAPK signaling pathway_Homo sapiens_hsa040100.30020539
132Hedgehog signaling pathway_Homo sapiens_hsa043400.29112822
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27786180
134Basal cell carcinoma_Homo sapiens_hsa052170.27307525
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25433745
136Tight junction_Homo sapiens_hsa045300.25105411
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25074590
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22717412
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20363260
140AMPK signaling pathway_Homo sapiens_hsa041520.19461208
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18364800
142Influenza A_Homo sapiens_hsa051640.17478565
143Arachidonic acid metabolism_Homo sapiens_hsa005900.16493794
144Shigellosis_Homo sapiens_hsa051310.16085508
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.16075140
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.15030882
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.14793108
148Apoptosis_Homo sapiens_hsa042100.13387477
149Glucagon signaling pathway_Homo sapiens_hsa049220.13313221
150Alcoholism_Homo sapiens_hsa050340.10451337
151Jak-STAT signaling pathway_Homo sapiens_hsa046300.10328753

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