KBTBD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcriptional activator, having been shown to increase the transcription of activator protein-1 and serum response element. The encoded protein can also form a complex with KBTBD6 and CUL3, which regulates the ubiquitylation and degradation of TIAM1, which is a regulator of RAC1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.15825334
2pyrimidine nucleobase catabolic process (GO:0006208)5.09169584
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.97075667
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.81009659
5layer formation in cerebral cortex (GO:0021819)4.72553302
6regulation of development, heterochronic (GO:0040034)4.70373945
7synaptic vesicle exocytosis (GO:0016079)4.67625141
8synaptic vesicle maturation (GO:0016188)4.63922477
9vocalization behavior (GO:0071625)4.61214559
10neuron cell-cell adhesion (GO:0007158)4.56493860
11regulation of synaptic vesicle exocytosis (GO:2000300)4.49427017
12regulation of timing of cell differentiation (GO:0048505)4.49278707
13glutamate secretion (GO:0014047)4.49134674
14locomotory exploration behavior (GO:0035641)4.39176640
15cornea development in camera-type eye (GO:0061303)4.38331415
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.29253992
17protein localization to synapse (GO:0035418)4.24522655
18regulation of glutamate receptor signaling pathway (GO:1900449)4.02704943
19regulation of synaptic vesicle transport (GO:1902803)4.01539321
20nucleobase catabolic process (GO:0046113)4.00642796
21glutamate receptor signaling pathway (GO:0007215)3.83044063
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.78549350
23synaptic vesicle docking involved in exocytosis (GO:0016081)3.75651414
24neurotransmitter secretion (GO:0007269)3.72278772
25auditory behavior (GO:0031223)3.68186432
26gamma-aminobutyric acid signaling pathway (GO:0007214)3.66753154
27dorsal/ventral axis specification (GO:0009950)3.63147185
28neurotransmitter-gated ion channel clustering (GO:0072578)3.61544737
29exploration behavior (GO:0035640)3.60225295
30positive regulation of synapse maturation (GO:0090129)3.56580140
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.56246726
32cell proliferation in forebrain (GO:0021846)3.55603297
33innervation (GO:0060384)3.55086672
34neuronal action potential propagation (GO:0019227)3.54035095
35limb bud formation (GO:0060174)3.49953503
36dendritic spine morphogenesis (GO:0060997)3.47501331
37sulfation (GO:0051923)3.47342133
38synaptic transmission, glutamatergic (GO:0035249)3.46875313
39neuron-neuron synaptic transmission (GO:0007270)3.44617768
40cellular potassium ion homeostasis (GO:0030007)3.41500870
41regulation of neuronal synaptic plasticity (GO:0048168)3.40903547
42gamma-aminobutyric acid transport (GO:0015812)3.39665486
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.38236493
44regulation of vesicle fusion (GO:0031338)3.36164120
45neuron recognition (GO:0008038)3.29993608
46DNA double-strand break processing (GO:0000729)3.26121666
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25305766
48nonmotile primary cilium assembly (GO:0035058)3.24964915
49regulation of synapse structural plasticity (GO:0051823)3.23663244
50long-term memory (GO:0007616)3.22916842
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.21446547
52positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.21172443
53mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.21172443
54proline transport (GO:0015824)3.20609160
55negative regulation of hormone metabolic process (GO:0032351)3.18568834
56negative regulation of hormone biosynthetic process (GO:0032353)3.18568834
57synaptic vesicle endocytosis (GO:0048488)3.18287138
58response to histamine (GO:0034776)3.16823411
59protein polyglutamylation (GO:0018095)3.16412137
60regulation of dendritic spine morphogenesis (GO:0061001)3.14302548
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.11717587
62regulation of ARF protein signal transduction (GO:0032012)3.10222703
63negative regulation of DNA recombination (GO:0045910)3.08303758
64protein targeting to Golgi (GO:0000042)3.07430957
65photoreceptor cell development (GO:0042461)3.07078109
66positive regulation of membrane potential (GO:0045838)3.06708749
67mechanosensory behavior (GO:0007638)3.05962422
68axonal fasciculation (GO:0007413)3.05804023
69regulation of clathrin-mediated endocytosis (GO:2000369)3.05761948
70sodium ion export (GO:0071436)3.05133386
71long-term synaptic potentiation (GO:0060291)3.04322374
72cerebral cortex radially oriented cell migration (GO:0021799)3.03338794
73presynaptic membrane assembly (GO:0097105)3.03310685
74artery development (GO:0060840)3.02235369
75startle response (GO:0001964)3.00490959
76neurotransmitter transport (GO:0006836)3.00463383
77regulation of excitatory postsynaptic membrane potential (GO:0060079)2.98441561
78otic vesicle formation (GO:0030916)2.97948514
79response to auditory stimulus (GO:0010996)2.97634375
80activation of protein kinase A activity (GO:0034199)2.96850799
81positive regulation of vesicle fusion (GO:0031340)2.96586300
82pituitary gland development (GO:0021983)2.96379709
83eye photoreceptor cell development (GO:0042462)2.96042624
84hindbrain development (GO:0030902)2.93076035
85regulation of synaptic plasticity (GO:0048167)2.92847980
86synapse assembly (GO:0007416)2.91641578
87water-soluble vitamin biosynthetic process (GO:0042364)2.91077433
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90466873
89regulation of calcium ion-dependent exocytosis (GO:0017158)2.90052629
90regulation of postsynaptic membrane potential (GO:0060078)2.89550513
91transmission of nerve impulse (GO:0019226)2.89501694
92behavioral fear response (GO:0001662)2.88014032
93behavioral defense response (GO:0002209)2.88014032
94neural tube formation (GO:0001841)2.87185043
95cerebellar Purkinje cell differentiation (GO:0021702)2.86532044
96postsynaptic membrane organization (GO:0001941)2.85040294
97positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.83820330
98retinal ganglion cell axon guidance (GO:0031290)2.83134606
99dendrite morphogenesis (GO:0048813)2.82243945
100regulation of DNA endoreduplication (GO:0032875)2.80346936
101somatic diversification of immune receptors via somatic mutation (GO:0002566)2.78618632
102somatic hypermutation of immunoglobulin genes (GO:0016446)2.78618632
103regulation of neurotransmitter levels (GO:0001505)2.78250752
104regulation of neurotransmitter secretion (GO:0046928)2.77217181
105vesicle transport along microtubule (GO:0047496)2.76673143
106establishment of protein localization to Golgi (GO:0072600)2.75973139
107membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.74876256
108negative regulation of transcription regulatory region DNA binding (GO:2000678)2.74176170
109behavioral response to nicotine (GO:0035095)2.73389206
110somite development (GO:0061053)2.71741425
111righting reflex (GO:0060013)2.71294285
112long term synaptic depression (GO:0060292)2.69552172
113presynaptic membrane organization (GO:0097090)2.68855747
114fear response (GO:0042596)2.67701367
115synapse organization (GO:0050808)2.67637883
116nerve growth factor signaling pathway (GO:0038180)2.67087131
117cerebellar granule cell differentiation (GO:0021707)2.67065412
118cochlea development (GO:0090102)2.66847374
119intra-S DNA damage checkpoint (GO:0031573)2.66300587
120establishment of nucleus localization (GO:0040023)2.66059327
121synapsis (GO:0007129)2.65747566
122G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.65378489
123positive regulation of mitochondrial fission (GO:0090141)2.65237835
124neuromuscular process controlling balance (GO:0050885)2.64779127
125suckling behavior (GO:0001967)2.63852312
126regulation of dendritic spine development (GO:0060998)2.63659135
127regulation of helicase activity (GO:0051095)2.63637820
128cilium morphogenesis (GO:0060271)2.62539026
129negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.61413210
130regulation of neurotransmitter transport (GO:0051588)2.61337575
131regulation of synapse maturation (GO:0090128)2.61231302
132intraspecies interaction between organisms (GO:0051703)2.60867114
133social behavior (GO:0035176)2.60867114
134replication fork processing (GO:0031297)2.59501234
135positive regulation of dendritic spine morphogenesis (GO:0061003)2.59299982
136negative regulation of DNA-dependent DNA replication (GO:2000104)2.57866950
137organelle transport along microtubule (GO:0072384)2.55987402
138regulation of meiosis I (GO:0060631)2.55878377
139retrograde transport, vesicle recycling within Golgi (GO:0000301)2.55277132
140synaptic transmission (GO:0007268)2.54261639
141activated T cell proliferation (GO:0050798)2.53803722
142intraciliary transport (GO:0042073)2.53330375
143regulation of collateral sprouting (GO:0048670)2.51151170
144pre-miRNA processing (GO:0031054)2.48974817
145regulation of telomere maintenance (GO:0032204)2.48564145
146histone H3-K9 methylation (GO:0051567)2.46652737
147glandular epithelial cell differentiation (GO:0002067)2.46215365
148establishment of mitochondrion localization (GO:0051654)2.44754880
149substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.43568315
150substrate-independent telencephalic tangential migration (GO:0021826)2.43568315
151positive regulation of neuroblast proliferation (GO:0002052)2.42212149
152protein localization to cilium (GO:0061512)2.41098819
153olfactory bulb development (GO:0021772)2.40719462
154centriole replication (GO:0007099)2.40626529
155single strand break repair (GO:0000012)2.40037401
156spermatid nucleus differentiation (GO:0007289)2.39694062
157regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.39469072
158signal transduction involved in regulation of gene expression (GO:0023019)2.39428287
159spinal cord motor neuron differentiation (GO:0021522)2.36480600
160histone H2A monoubiquitination (GO:0035518)2.36262637
161neuron fate determination (GO:0048664)2.35300492
162regulation of DNA methylation (GO:0044030)2.34877517
163histone mRNA metabolic process (GO:0008334)2.33225183
164mitochondrial respiratory chain complex I assembly (GO:0032981)2.32976305
165NADH dehydrogenase complex assembly (GO:0010257)2.32976305
166mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.32976305
167negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.32189027
168negative regulation of translation, ncRNA-mediated (GO:0040033)2.32189027
169regulation of translation, ncRNA-mediated (GO:0045974)2.32189027
170DNA damage response, detection of DNA damage (GO:0042769)2.30965412
171dentate gyrus development (GO:0021542)2.30248768
172chromatin remodeling at centromere (GO:0031055)2.29799826
173central nervous system projection neuron axonogenesis (GO:0021952)2.28775518
174epithelial cilium movement (GO:0003351)2.25623100
175regulation of feeding behavior (GO:0060259)2.24331916
176limb development (GO:0060173)2.24331207
177appendage development (GO:0048736)2.24331207
178epithelial cell differentiation involved in kidney development (GO:0035850)2.24303045
179calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.23699883
180gastrulation with mouth forming second (GO:0001702)2.23128921
181protein-cofactor linkage (GO:0018065)2.21120123
182maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.20571364
183resolution of meiotic recombination intermediates (GO:0000712)2.20216537
184regulation of glucokinase activity (GO:0033131)2.19730079
185regulation of hexokinase activity (GO:1903299)2.19730079

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.19724000
2GBX2_23144817_ChIP-Seq_PC3_Human3.11423117
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46711516
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.45296822
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36895507
6TAF15_26573619_Chip-Seq_HEK293_Human2.35904839
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.34919224
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32977237
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28615315
10REST_21632747_ChIP-Seq_MESCs_Mouse2.28311438
11AR_21572438_ChIP-Seq_LNCaP_Human2.10984836
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.08793253
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.07117374
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07096122
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.07040115
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03119808
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02142104
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01256214
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00683428
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00683428
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.99544645
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96963752
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.94351662
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93798692
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92378370
26IGF1R_20145208_ChIP-Seq_DFB_Human1.90060822
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.86333800
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86117784
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85326981
30SMAD4_21799915_ChIP-Seq_A2780_Human1.83670676
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78381423
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.77540113
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73986642
34IRF1_19129219_ChIP-ChIP_H3396_Human1.73693019
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69831205
36FUS_26573619_Chip-Seq_HEK293_Human1.69282609
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69003323
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67686874
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65654579
40DROSHA_22980978_ChIP-Seq_HELA_Human1.65574189
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.64924232
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62025165
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60712102
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.59594232
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59289969
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59187732
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.59130763
48* EST1_17652178_ChIP-ChIP_JURKAT_Human1.58832365
49P300_19829295_ChIP-Seq_ESCs_Human1.57250044
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.55837007
51SOX2_16153702_ChIP-ChIP_HESCs_Human1.54806608
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.52702231
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50717314
54* STAT3_23295773_ChIP-Seq_U87_Human1.50197956
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48014012
56* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47950904
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.47759135
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.47516467
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.46021966
60CBP_20019798_ChIP-Seq_JUKART_Human1.45262090
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45262090
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44919521
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44711965
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44656736
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43584658
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42382656
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41588492
68AR_25329375_ChIP-Seq_VCAP_Human1.40575209
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39946273
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38317343
71ELK1_19687146_ChIP-ChIP_HELA_Human1.38269729
72RNF2_27304074_Chip-Seq_NSC_Mouse1.37700795
73* MYC_18940864_ChIP-ChIP_HL60_Human1.31800168
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.28730114
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28637664
76TCF4_23295773_ChIP-Seq_U87_Human1.27580859
77AR_19668381_ChIP-Seq_PC3_Human1.25556534
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25009281
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22726196
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22599073
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22205546
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22036994
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21092296
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.18297780
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18236454
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.18218855
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18162917
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.17510759
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17127473
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16866832
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16866832
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16191923
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16049176
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15998603
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.15835284
96PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15297003
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15244448
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.15166928
99ZNF274_21170338_ChIP-Seq_K562_Hela1.14256383
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14245940
101E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13686032
102SALL1_21062744_ChIP-ChIP_HESCs_Human1.13211122
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.12620228
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11480188
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11400000
106SOX9_26525672_Chip-Seq_HEART_Mouse1.10079334
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10030869
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08995945
109IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08616314
110BCAT_22108803_ChIP-Seq_LS180_Human1.07414673
111TP53_22573176_ChIP-Seq_HFKS_Human1.07345067
112KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07260920
113RUNX2_22187159_ChIP-Seq_PCA_Human1.06833701
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06189316
115PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06127443
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.05026252
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04723961
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04695292
119PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04323065
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03172812
121* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03024460
122* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02598918
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.02138723
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02083840
125SMAD3_21741376_ChIP-Seq_ESCs_Human1.01673473
126TP53_16413492_ChIP-PET_HCT116_Human1.00848782
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00730981
128KDM2B_26808549_Chip-Seq_REH_Human1.00446299
129TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00389218
130GATA1_26923725_Chip-Seq_HPCs_Mouse0.99773113
131JUN_21703547_ChIP-Seq_K562_Human0.99337975
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98862482
133SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98293876
134PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98247774
135TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98205333
136AHR_22903824_ChIP-Seq_MCF-7_Human0.97379693
137ER_23166858_ChIP-Seq_MCF-7_Human0.97253788
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97025261
139* RING1B_27294783_Chip-Seq_ESCs_Mouse0.96752792
140* SMAD4_21741376_ChIP-Seq_EPCs_Human0.95896611
141EWS_26573619_Chip-Seq_HEK293_Human0.95424814
142FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94936753
143VDR_22108803_ChIP-Seq_LS180_Human0.92967519

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.86829444
2MP0003880_abnormal_central_pattern4.63782435
3MP0003635_abnormal_synaptic_transmissio3.83464030
4MP0004270_analgesia3.59264495
5MP0008789_abnormal_olfactory_epithelium3.24803466
6MP0002063_abnormal_learning/memory/cond3.17545260
7MP0009745_abnormal_behavioral_response2.95764533
8MP0002064_seizures2.73556320
9MP0001968_abnormal_touch/_nociception2.65065469
10MP0002572_abnormal_emotion/affect_behav2.59979047
11MP0003787_abnormal_imprinting2.49368505
12MP0009046_muscle_twitch2.47737676
13MP0002734_abnormal_mechanical_nocicepti2.42057663
14MP0001486_abnormal_startle_reflex2.31607518
15MP0005423_abnormal_somatic_nervous2.20052335
16MP0002272_abnormal_nervous_system2.13851771
17MP0002736_abnormal_nociception_after2.07340831
18MP0003329_amyloid_beta_deposits2.05136630
19MP0009780_abnormal_chondrocyte_physiolo1.99162580
20MP0000049_abnormal_middle_ear1.98934314
21MP0001502_abnormal_circadian_rhythm1.95718518
22MP0005646_abnormal_pituitary_gland1.94798976
23MP0002909_abnormal_adrenal_gland1.92461128
24MP0001984_abnormal_olfaction1.90678571
25MP0003890_abnormal_embryonic-extraembry1.85039342
26MP0002822_catalepsy1.80129071
27MP0002938_white_spotting1.78926096
28MP0001501_abnormal_sleep_pattern1.78142761
29MP0000778_abnormal_nervous_system1.77874181
30MP0002184_abnormal_innervation1.77056986
31MP0002067_abnormal_sensory_capabilities1.72419432
32MP0001440_abnormal_grooming_behavior1.70903563
33MP0004924_abnormal_behavior1.70214149
34MP0005386_behavior/neurological_phenoty1.70214149
35MP0006072_abnormal_retinal_apoptosis1.68890739
36MP0005551_abnormal_eye_electrophysiolog1.67503584
37MP0006276_abnormal_autonomic_nervous1.65241937
38MP0001970_abnormal_pain_threshold1.64761003
39MP0002733_abnormal_thermal_nociception1.64332192
40MP0002557_abnormal_social/conspecific_i1.57687416
41MP0008058_abnormal_DNA_repair1.56324423
42MP0001905_abnormal_dopamine_level1.53165757
43MP0010234_abnormal_vibrissa_follicle1.52965487
44MP0002735_abnormal_chemical_nociception1.51117576
45MP0003567_abnormal_fetal_cardiomyocyte1.50845288
46MP0005187_abnormal_penis_morphology1.48767062
47MP0002160_abnormal_reproductive_system1.48584707
48MP0004133_heterotaxia1.48540392
49MP0004811_abnormal_neuron_physiology1.44053490
50MP0008569_lethality_at_weaning1.41533190
51MP0001293_anophthalmia1.40765275
52MP0000566_synostosis1.39589959
53MP0003879_abnormal_hair_cell1.39418662
54MP0000955_abnormal_spinal_cord1.37750195
55MP0003646_muscle_fatigue1.36277929
56MP0003119_abnormal_digestive_system1.35850894
57MP0002882_abnormal_neuron_morphology1.35530540
58MP0002837_dystrophic_cardiac_calcinosis1.34424434
59MP0010386_abnormal_urinary_bladder1.33515538
60MP0001529_abnormal_vocalization1.30769870
61MP0002066_abnormal_motor_capabilities/c1.29859633
62MP0008877_abnormal_DNA_methylation1.28170462
63MP0003937_abnormal_limbs/digits/tail_de1.27921173
64MP0003121_genomic_imprinting1.27084795
65MP0004885_abnormal_endolymph1.26831689
66MP0003938_abnormal_ear_development1.25820630
67MP0000631_abnormal_neuroendocrine_gland1.21842256
68MP0002152_abnormal_brain_morphology1.19924242
69MP0004142_abnormal_muscle_tone1.17869028
70MP0001485_abnormal_pinna_reflex1.13286779
71MP0002233_abnormal_nose_morphology1.10200997
72MP0003718_maternal_effect1.09941078
73MP0001286_abnormal_eye_development1.07613157
74MP0004043_abnormal_pH_regulation1.06721708
75MP0008995_early_reproductive_senescence1.06708017
76MP0002751_abnormal_autonomic_nervous1.05477082
77MP0003011_delayed_dark_adaptation1.05008028
78MP0005389_reproductive_system_phenotype1.04662697
79MP0003633_abnormal_nervous_system1.04599308
80MP0002229_neurodegeneration1.04182627
81MP0003136_yellow_coat_color1.02700247
82MP0003755_abnormal_palate_morphology1.02648790
83MP0004233_abnormal_muscle_weight1.01793971
84MP0003123_paternal_imprinting1.00987180
85MP0002090_abnormal_vision0.98997604
86MP0003631_nervous_system_phenotype0.98126693
87MP0000026_abnormal_inner_ear0.97602670
88MP0001188_hyperpigmentation0.96021166
89MP0000639_abnormal_adrenal_gland0.96015729
90MP0005248_abnormal_Harderian_gland0.95368227
91MP0005253_abnormal_eye_physiology0.94145992
92MP0010094_abnormal_chromosome_stability0.92711083
93MP0003303_peritoneal_inflammation0.92035421
94MP0002653_abnormal_ependyma_morphology0.90673661
95MP0000604_amyloidosis0.90187085
96MP0005084_abnormal_gallbladder_morpholo0.89471145
97MP0002928_abnormal_bile_duct0.89083545
98MP0008961_abnormal_basal_metabolism0.88685251
99MP0003632_abnormal_nervous_system0.88385234
100MP0002210_abnormal_sex_determination0.86607642
101MP0002638_abnormal_pupillary_reflex0.86399872
102MP0004742_abnormal_vestibular_system0.86390673
103MP0001963_abnormal_hearing_physiology0.85750036
104MP0000428_abnormal_craniofacial_morphol0.85073911
105MP0005391_vision/eye_phenotype0.84194749
106MP0003221_abnormal_cardiomyocyte_apopto0.83917874
107MP0000569_abnormal_digit_pigmentation0.83879490
108MP0003942_abnormal_urinary_system0.83637124
109MP0002069_abnormal_eating/drinking_beha0.83151318
110MP0000613_abnormal_salivary_gland0.82602031
111MP0002234_abnormal_pharynx_morphology0.82336757
112MP0002102_abnormal_ear_morphology0.82158424
113MP0003122_maternal_imprinting0.81355650
114MP0002752_abnormal_somatic_nervous0.81174014
115MP0004145_abnormal_muscle_electrophysio0.80919414
116MP0008057_abnormal_DNA_replication0.80551501
117MP0004085_abnormal_heartbeat0.78827281
118MP0002277_abnormal_respiratory_mucosa0.77643269
119MP0003861_abnormal_nervous_system0.77518718
120MP0003935_abnormal_craniofacial_develop0.77445328
121MP0002697_abnormal_eye_size0.77356670
122MP0008872_abnormal_physiological_respon0.76866422
123MP0000653_abnormal_sex_gland0.76150970
124MP0005535_abnormal_body_temperature0.76026243
125MP0001177_atelectasis0.75644141
126MP0000383_abnormal_hair_follicle0.75353484
127MP0001145_abnormal_male_reproductive0.75334642
128MP0004197_abnormal_fetal_growth/weight/0.74944011
129MP0008875_abnormal_xenobiotic_pharmacok0.74640569
130MP0004858_abnormal_nervous_system0.71655076
131MP0003868_abnormal_feces_composition0.70762027
132MP0003634_abnormal_glial_cell0.70090127
133MP0003699_abnormal_female_reproductive0.70002108
134MP0004215_abnormal_myocardial_fiber0.69286255
135MP0005499_abnormal_olfactory_system0.69036262
136MP0005394_taste/olfaction_phenotype0.69036262
137MP0004484_altered_response_of0.68712891
138MP0002161_abnormal_fertility/fecundity0.68384169
139MP0005195_abnormal_posterior_eye0.67770535
140MP0005451_abnormal_body_composition0.66727778
141MP0001929_abnormal_gametogenesis0.66321672
142MP0003698_abnormal_male_reproductive0.65985132
143MP0006292_abnormal_olfactory_placode0.65970751

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.22052342
2Myokymia (HP:0002411)4.99636563
3Focal seizures (HP:0007359)4.51312013
4Atonic seizures (HP:0010819)4.35297165
5Epileptic encephalopathy (HP:0200134)4.28345072
6Visual hallucinations (HP:0002367)4.15958610
7Insidious onset (HP:0003587)3.87275737
8Termporal pattern (HP:0011008)3.87275737
9True hermaphroditism (HP:0010459)3.60980985
10Papillary thyroid carcinoma (HP:0002895)3.57872592
11Progressive cerebellar ataxia (HP:0002073)3.53402332
12Febrile seizures (HP:0002373)3.37177959
13Absence seizures (HP:0002121)3.36134059
14Pancreatic fibrosis (HP:0100732)3.27144797
15Action tremor (HP:0002345)3.27136572
16Urinary bladder sphincter dysfunction (HP:0002839)3.26592030
17Pancreatic cysts (HP:0001737)3.26284783
18Optic nerve hypoplasia (HP:0000609)3.23373493
19Generalized tonic-clonic seizures (HP:0002069)3.20997416
20Abnormality of the corticospinal tract (HP:0002492)3.19866336
21Hyperventilation (HP:0002883)3.10594115
22Impaired vibration sensation in the lower limbs (HP:0002166)3.05231044
23Broad-based gait (HP:0002136)3.00478908
24Epileptiform EEG discharges (HP:0011182)2.98166628
25Papilledema (HP:0001085)2.97251792
26Medial flaring of the eyebrow (HP:0010747)2.96445874
27Septo-optic dysplasia (HP:0100842)2.95792797
28Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.95659878
29EEG with generalized epileptiform discharges (HP:0011198)2.94640819
30Dialeptic seizures (HP:0011146)2.92905391
31Excessive salivation (HP:0003781)2.91567126
32Drooling (HP:0002307)2.91567126
33Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.85023064
34Degeneration of the lateral corticospinal tracts (HP:0002314)2.85023064
35Spastic gait (HP:0002064)2.83284105
36Congenital primary aphakia (HP:0007707)2.80104539
37Dysdiadochokinesis (HP:0002075)2.79479450
38Hypsarrhythmia (HP:0002521)2.77010265
39Dysmetria (HP:0001310)2.76914526
40Neurofibrillary tangles (HP:0002185)2.76384672
41Genital tract atresia (HP:0001827)2.75880035
42Cerebral inclusion bodies (HP:0100314)2.75325402
43Genetic anticipation (HP:0003743)2.71798751
44Urinary urgency (HP:0000012)2.70665474
45Aplasia/Hypoplasia of the fovea (HP:0008060)2.70610621
46Hypoplasia of the fovea (HP:0007750)2.70610621
47Vaginal atresia (HP:0000148)2.69650346
48Colon cancer (HP:0003003)2.68425654
49Gaze-evoked nystagmus (HP:0000640)2.66645207
50Mutism (HP:0002300)2.66549958
51Nephronophthisis (HP:0000090)2.65684920
52Pendular nystagmus (HP:0012043)2.61349225
53Nephrogenic diabetes insipidus (HP:0009806)2.59641457
54Male infertility (HP:0003251)2.58547440
55Lower limb asymmetry (HP:0100559)2.57581538
56Truncal ataxia (HP:0002078)2.49192788
57Ankle clonus (HP:0011448)2.48299871
58Central scotoma (HP:0000603)2.46380713
59Supranuclear gaze palsy (HP:0000605)2.43776974
60Depression (HP:0000716)2.43634973
61Abnormality of the fovea (HP:0000493)2.42858800
62Torticollis (HP:0000473)2.41900006
63Abnormality of macular pigmentation (HP:0008002)2.39958975
64Postural instability (HP:0002172)2.38670825
65Progressive inability to walk (HP:0002505)2.37077113
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.35875258
67Cortical dysplasia (HP:0002539)2.34873500
68Volvulus (HP:0002580)2.34454673
69Amyotrophic lateral sclerosis (HP:0007354)2.33279680
70Methylmalonic acidemia (HP:0002912)2.31291781
71Poor coordination (HP:0002370)2.27792429
72Abnormal eating behavior (HP:0100738)2.26840480
73Chronic hepatic failure (HP:0100626)2.26486278
74Dysmetric saccades (HP:0000641)2.26418772
75Amblyopia (HP:0000646)2.25240484
76Abnormality of midbrain morphology (HP:0002418)2.25234558
77Molar tooth sign on MRI (HP:0002419)2.25234558
78Focal dystonia (HP:0004373)2.25211217
79Abnormality of chromosome stability (HP:0003220)2.24738887
80Generalized myoclonic seizures (HP:0002123)2.24316755
81Specific learning disability (HP:0001328)2.24061618
82Abnormality of the lower motor neuron (HP:0002366)2.24017651
83Impaired vibratory sensation (HP:0002495)2.23810162
84Abolished electroretinogram (ERG) (HP:0000550)2.21963217
85Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21641502
86Intention tremor (HP:0002080)2.20287339
87Anxiety (HP:0000739)2.20131824
88Medulloblastoma (HP:0002885)2.17980284
89Impaired smooth pursuit (HP:0007772)2.16668143
90Abnormality of the labia minora (HP:0012880)2.14877226
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.14723610
92Poor eye contact (HP:0000817)2.14470523
93Meckel diverticulum (HP:0002245)2.13479062
94Aplasia/Hypoplasia of the tongue (HP:0010295)2.13093044
95Hemiparesis (HP:0001269)2.12921283
96Status epilepticus (HP:0002133)2.11982915
97Facial hemangioma (HP:0000329)2.10361128
98Hypoplastic pelvis (HP:0008839)2.06822103
99Abnormality of the ileum (HP:0001549)2.06797951
100Blue irides (HP:0000635)2.05379356
101Optic nerve coloboma (HP:0000588)2.05247026
102Thyroid carcinoma (HP:0002890)2.04914882
103Abnormal lung lobation (HP:0002101)2.04833270
104Abnormality of the renal medulla (HP:0100957)2.04335540
105Hyperglycinemia (HP:0002154)2.03676728
106Abnormal social behavior (HP:0012433)2.03190231
107Impaired social interactions (HP:0000735)2.03190231
108Megalencephaly (HP:0001355)2.02664574
109Arterial tortuosity (HP:0005116)2.02254479
110Abnormal rod and cone electroretinograms (HP:0008323)2.00871328
111Craniofacial dystonia (HP:0012179)1.98739040
112Widely spaced teeth (HP:0000687)1.98639214
113Agitation (HP:0000713)1.98018333
114Gait imbalance (HP:0002141)1.97337345
115Male pseudohermaphroditism (HP:0000037)1.97157000
116Absent speech (HP:0001344)1.96506020
117Lower limb muscle weakness (HP:0007340)1.94719604
118Anencephaly (HP:0002323)1.93751338
119Cystic liver disease (HP:0006706)1.92754641
120Abnormality of ocular smooth pursuit (HP:0000617)1.92703911
121Congenital stationary night blindness (HP:0007642)1.92615206
122Obstructive sleep apnea (HP:0002870)1.91607089
123Clonus (HP:0002169)1.91276525
124Polyphagia (HP:0002591)1.90721449
125Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.90721102
126Sclerocornea (HP:0000647)1.89782546
127Broad foot (HP:0001769)1.89444217
128Gonadotropin excess (HP:0000837)1.88860413
129Postaxial foot polydactyly (HP:0001830)1.87114585
130Postaxial hand polydactyly (HP:0001162)1.86764899
131Scanning speech (HP:0002168)1.86072510
132Morphological abnormality of the pyramidal tract (HP:0002062)1.83698882
133Intestinal atresia (HP:0011100)1.83359753
134Aplasia/Hypoplasia of the sternum (HP:0006714)1.82912082
135Limb dystonia (HP:0002451)1.82360771
136Aplasia/Hypoplasia of the lens (HP:0008063)1.82283016
137Short 4th metacarpal (HP:0010044)1.80032393
138Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.80032393
139Bradykinesia (HP:0002067)1.79785582
140Lissencephaly (HP:0001339)1.79432495
141Oligodactyly (hands) (HP:0001180)1.78795921
142Inappropriate behavior (HP:0000719)1.78631256
143Small hand (HP:0200055)1.78407092
144Abnormality of salivation (HP:0100755)1.77890835
145Abnormality of binocular vision (HP:0011514)1.77308880
146Diplopia (HP:0000651)1.77308880
147Decreased central vision (HP:0007663)1.77111220
148Inability to walk (HP:0002540)1.74659855
149Decreased testicular size (HP:0008734)1.74300997
150Rhabdomyosarcoma (HP:0002859)1.73630617
151Short tibia (HP:0005736)1.73042291
152Aplasia/Hypoplasia of the tibia (HP:0005772)1.71450237
153Patellar aplasia (HP:0006443)1.70835331
154Posterior subcapsular cataract (HP:0007787)1.70780606
155Aplasia/Hypoplasia of the patella (HP:0006498)1.70753954
156Anomalous pulmonary venous return (HP:0010772)1.69016532
157Absent septum pellucidum (HP:0001331)1.68251195
158Fetal akinesia sequence (HP:0001989)1.68183592
159Abnormal respiratory motile cilium physiology (HP:0012261)1.67743977
160Vitreoretinal degeneration (HP:0000655)1.67329285
161Infertility (HP:0000789)1.67219933
162Hip dysplasia (HP:0001385)1.66296422
163Morphological abnormality of the middle ear (HP:0008609)1.65237900
164Preaxial hand polydactyly (HP:0001177)1.64765267
165Gait ataxia (HP:0002066)1.64397469
166Micropenis (HP:0000054)1.64247835
167Abnormal biliary tract physiology (HP:0012439)1.64227938
168Bile duct proliferation (HP:0001408)1.64227938
169Incomplete penetrance (HP:0003829)1.64017274
170Stenosis of the external auditory canal (HP:0000402)1.63544267
171Narrow forehead (HP:0000341)1.63085496
172Gastrointestinal atresia (HP:0002589)1.62694823
173Supernumerary spleens (HP:0009799)1.62189140
174Furrowed tongue (HP:0000221)1.62108841
175Hepatoblastoma (HP:0002884)1.61871478
176Esotropia (HP:0000565)1.61416233
177Methylmalonic aciduria (HP:0012120)1.59539739
178Hyperinsulinemic hypoglycemia (HP:0000825)1.59467558
179Sloping forehead (HP:0000340)1.59210104

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.22338029
2EPHA43.40130202
3MAP3K43.01890062
4NTRK32.89994916
5KSR22.87505157
6MARK12.78906224
7MAP2K72.53770539
8MAP4K22.43159748
9PAK62.42940109
10TAOK32.36829515
11NTRK22.27762195
12TRIM282.25474337
13DAPK22.12397471
14PRKD32.10747710
15BCR2.09852846
16LATS12.08896559
17LATS22.02771192
18SRPK12.01307061
19VRK11.86667138
20ZAK1.84350637
21GRK11.82120070
22MAP2K41.79524556
23MINK11.79477716
24KSR11.74625882
25BCKDK1.68629329
26CASK1.68242323
27MAP3K61.67487704
28CDC71.64388518
29MKNK21.61550270
30BMPR21.61238018
31PLK41.56978546
32MAPK131.50870738
33TAOK11.46982317
34MAP3K131.45740647
35STK381.43137056
36DYRK31.42443936
37MOS1.42086496
38BMPR1B1.34455471
39CSNK1G21.33725072
40PLK31.31070637
41NTRK11.30780436
42NUAK11.29084148
43CAMKK11.27266842
44MKNK11.26329287
45CDK51.18942914
46SGK4941.17871555
47SGK2231.17871555
48RAF11.17313189
49SGK21.16526448
50RET1.15922682
51ERBB41.15589157
52PNCK1.13363463
53RPS6KA41.13004624
54TAF11.10390050
55TYRO31.07342750
56MAP3K121.05676038
57PLK21.05178860
58ACVR1B1.02201898
59VRK21.00619064
60BRD40.99442158
61ERBB30.99317234
62FRK0.99188604
63ADRBK20.98454534
64TSSK60.96656868
65OXSR10.95836579
66SGK30.92787964
67WEE10.92185179
68ARAF0.91999394
69STK110.90761053
70MAP3K20.90428797
71CAMK2A0.90069853
72CAMKK20.89609950
73DYRK1A0.88434840
74STK160.88276128
75INSRR0.88018533
76STK38L0.87537671
77DAPK10.87369862
78CSNK1G30.86427671
79PRKCE0.86411219
80CSNK1G10.84765667
81RIPK40.81497978
82TNIK0.81481908
83FES0.80183641
84CSNK1A1L0.78935535
85CDK190.73563218
86TLK10.73340430
87MAP3K10.73041806
88PAK30.71526540
89BRAF0.71139044
90ATR0.70815342
91STK390.70784486
92GRK50.69892044
93MARK20.67490625
94SGK10.67108490
95PHKG20.67049470
96PHKG10.67049470
97TTK0.66613199
98PLK10.66337250
99SIK20.65932018
100BUB10.65499192
101FGR0.63900318
102BRSK20.62926893
103PRKCG0.61648600
104EIF2AK30.60891376
105DYRK20.60143830
106PRKCH0.60140565
107PTK2B0.59997482
108UHMK10.59740793
109CDK150.59299262
110CAMK1G0.59072891
111CDK180.59017870
112MELK0.57842276
113PRKAA10.57315278
114HIPK20.56460294
115CDK140.55567729
116ATM0.55550187
117PRKCZ0.53856940
118TIE10.52486042
119PDK10.51747880
120DMPK0.51132309
121CAMK2B0.50575014
122PRPF4B0.50352255
123RPS6KB10.50241626
124MAPK100.49117496
125RPS6KA30.46354578
126YES10.45844754
127AURKA0.45417494
128NLK0.44849232
129FER0.44825416
130CSNK1A10.44298202
131PDPK10.44242996
132FGFR20.44157529
133NEK10.43963297
134CDK11A0.43560166
135CCNB10.42665728
136PINK10.42506432
137PRKD20.42134026
138CSNK1E0.40948689
139WNK40.40000126
140PRKACA0.39303922
141CDK30.39045673
142PRKACB0.38283754
143PKN10.38212143
144MAP3K50.37868579
145WNK30.36852439
146DYRK1B0.36843504
147PRKAA20.36428743
148CAMK10.35588734
149PRKG10.34827609
150CSNK1D0.33103361
151PRKDC0.31989050
152MAPK90.30072974

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.36599818
2Synaptic vesicle cycle_Homo sapiens_hsa047212.57392738
3Long-term potentiation_Homo sapiens_hsa047202.54551239
4GABAergic synapse_Homo sapiens_hsa047272.47442735
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46027458
6Glutamatergic synapse_Homo sapiens_hsa047242.43213722
7Circadian entrainment_Homo sapiens_hsa047132.42825495
8Olfactory transduction_Homo sapiens_hsa047402.40661033
9Mismatch repair_Homo sapiens_hsa034302.28182283
10Protein export_Homo sapiens_hsa030602.23515201
11Amphetamine addiction_Homo sapiens_hsa050312.20461966
12Morphine addiction_Homo sapiens_hsa050322.20341765
13Fanconi anemia pathway_Homo sapiens_hsa034602.18488308
14Steroid biosynthesis_Homo sapiens_hsa001002.08258809
15Basal transcription factors_Homo sapiens_hsa030222.07091163
16Insulin secretion_Homo sapiens_hsa049112.02068146
17Selenocompound metabolism_Homo sapiens_hsa004501.99099006
18Dopaminergic synapse_Homo sapiens_hsa047281.98639896
19Salivary secretion_Homo sapiens_hsa049701.91057392
20Renin secretion_Homo sapiens_hsa049241.80792324
21Cholinergic synapse_Homo sapiens_hsa047251.78980585
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78930555
23Long-term depression_Homo sapiens_hsa047301.75378596
24Non-homologous end-joining_Homo sapiens_hsa034501.73411796
25RNA degradation_Homo sapiens_hsa030181.73160177
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72239657
27Dorso-ventral axis formation_Homo sapiens_hsa043201.70176559
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.67902766
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64529057
30Homologous recombination_Homo sapiens_hsa034401.64298874
31Serotonergic synapse_Homo sapiens_hsa047261.62120571
32RNA transport_Homo sapiens_hsa030131.61850549
33Cocaine addiction_Homo sapiens_hsa050301.61013987
34Gastric acid secretion_Homo sapiens_hsa049711.60654283
35GnRH signaling pathway_Homo sapiens_hsa049121.58680060
36Circadian rhythm_Homo sapiens_hsa047101.55686704
37Oxytocin signaling pathway_Homo sapiens_hsa049211.55471462
38Oxidative phosphorylation_Homo sapiens_hsa001901.54694793
39Parkinsons disease_Homo sapiens_hsa050121.50623633
40Propanoate metabolism_Homo sapiens_hsa006401.49160223
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47876481
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44764097
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44618748
44Taste transduction_Homo sapiens_hsa047421.40167903
45Nitrogen metabolism_Homo sapiens_hsa009101.36462344
46Estrogen signaling pathway_Homo sapiens_hsa049151.34969606
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34436560
48Gap junction_Homo sapiens_hsa045401.33838443
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33518072
50RNA polymerase_Homo sapiens_hsa030201.32797856
51Hedgehog signaling pathway_Homo sapiens_hsa043401.32715737
52cAMP signaling pathway_Homo sapiens_hsa040241.32044729
53mRNA surveillance pathway_Homo sapiens_hsa030151.31435168
54Oocyte meiosis_Homo sapiens_hsa041141.30358523
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28533166
56Spliceosome_Homo sapiens_hsa030401.28390898
57Type II diabetes mellitus_Homo sapiens_hsa049301.23916196
58Nucleotide excision repair_Homo sapiens_hsa034201.23561951
59Ovarian steroidogenesis_Homo sapiens_hsa049131.19551096
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17101369
61Glioma_Homo sapiens_hsa052141.15420752
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14164209
63Calcium signaling pathway_Homo sapiens_hsa040201.13129004
64Phototransduction_Homo sapiens_hsa047441.12386002
65Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09613095
66Axon guidance_Homo sapiens_hsa043601.08061146
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07156035
68DNA replication_Homo sapiens_hsa030301.05217683
69Huntingtons disease_Homo sapiens_hsa050161.04316466
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03281316
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01121036
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01083731
73Basal cell carcinoma_Homo sapiens_hsa052170.99645971
74ErbB signaling pathway_Homo sapiens_hsa040120.99164634
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98771462
76Base excision repair_Homo sapiens_hsa034100.98312571
77Choline metabolism in cancer_Homo sapiens_hsa052310.96929296
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94865109
79Alzheimers disease_Homo sapiens_hsa050100.93650658
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93404016
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.93164989
82Renal cell carcinoma_Homo sapiens_hsa052110.91830337
83Collecting duct acid secretion_Homo sapiens_hsa049660.90492379
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90461792
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90211066
86Endometrial cancer_Homo sapiens_hsa052130.86790364
87mTOR signaling pathway_Homo sapiens_hsa041500.86524314
88Cell cycle_Homo sapiens_hsa041100.86335492
89Peroxisome_Homo sapiens_hsa041460.85663521
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85431932
91Melanogenesis_Homo sapiens_hsa049160.84444130
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.84038001
93Glucagon signaling pathway_Homo sapiens_hsa049220.81959991
94Pancreatic secretion_Homo sapiens_hsa049720.81950184
95MAPK signaling pathway_Homo sapiens_hsa040100.81297818
96Vitamin B6 metabolism_Homo sapiens_hsa007500.76589522
97Thyroid hormone synthesis_Homo sapiens_hsa049180.76404543
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75584550
99Colorectal cancer_Homo sapiens_hsa052100.72148274
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72117920
101VEGF signaling pathway_Homo sapiens_hsa043700.71728276
102Tryptophan metabolism_Homo sapiens_hsa003800.70239449
103Bile secretion_Homo sapiens_hsa049760.68793202
104Ras signaling pathway_Homo sapiens_hsa040140.68367391
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68274832
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66432608
107Hippo signaling pathway_Homo sapiens_hsa043900.66388430
108Cardiac muscle contraction_Homo sapiens_hsa042600.65124220
109beta-Alanine metabolism_Homo sapiens_hsa004100.64917061
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64807015
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64223654
112One carbon pool by folate_Homo sapiens_hsa006700.62624209
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60890224
114Non-small cell lung cancer_Homo sapiens_hsa052230.60676314
115Caffeine metabolism_Homo sapiens_hsa002320.59406774
116Alcoholism_Homo sapiens_hsa050340.59095460
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.58783356
118Pancreatic cancer_Homo sapiens_hsa052120.58420895
119Fatty acid elongation_Homo sapiens_hsa000620.57144211
120Arginine biosynthesis_Homo sapiens_hsa002200.56777849
121Folate biosynthesis_Homo sapiens_hsa007900.56368278
122Butanoate metabolism_Homo sapiens_hsa006500.56065078
123Retinol metabolism_Homo sapiens_hsa008300.55707484
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54900432
125Inositol phosphate metabolism_Homo sapiens_hsa005620.54751949
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54686532
127Linoleic acid metabolism_Homo sapiens_hsa005910.54087199
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.53651940
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52851537
130Prolactin signaling pathway_Homo sapiens_hsa049170.51981933
131Proteasome_Homo sapiens_hsa030500.51136244
132Ether lipid metabolism_Homo sapiens_hsa005650.49759688
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49622599
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48353335
135Wnt signaling pathway_Homo sapiens_hsa043100.47559649
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47136515
137Rap1 signaling pathway_Homo sapiens_hsa040150.46579509
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46446727
139Vibrio cholerae infection_Homo sapiens_hsa051100.46211997
140Insulin signaling pathway_Homo sapiens_hsa049100.46082150
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.44230914
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43096040
143Purine metabolism_Homo sapiens_hsa002300.42793197
144TGF-beta signaling pathway_Homo sapiens_hsa043500.42644176
145FoxO signaling pathway_Homo sapiens_hsa040680.42309643
146Metabolic pathways_Homo sapiens_hsa011000.41202332
147Melanoma_Homo sapiens_hsa052180.40238538
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38462023
149Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38196023
150Fatty acid metabolism_Homo sapiens_hsa012120.37646850
151Dilated cardiomyopathy_Homo sapiens_hsa054140.36461053
152Vitamin digestion and absorption_Homo sapiens_hsa049770.36030108
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.35501872
154Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34056813
155Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30859768
156Maturity onset diabetes of the young_Homo sapiens_hsa049500.30407797
157Prion diseases_Homo sapiens_hsa050200.29881012
158Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28907135
159Primary bile acid biosynthesis_Homo sapiens_hsa001200.28823756

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